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https://www.readbyqxmd.com/read/28634015/three-dimensional-3d-printed-model-for-deep-infiltrating-endometriosis-die-a-case-report
#1
Mobolaji O Ajao, Nisse V Clark, Tatiana Kelil, Sarah L Cohen, Jon I Einarsson
The combination of a thorough physical exam and imaging with either MRI or pelvic ultrasound are important in pre-operative planning for deep infiltrating endometriosis. Nevertheless, the 2-dimensional rendering of the pathology by imaging does not always accurately represent intra-operative findings. An in-depth topographical relationship and extent of surrounding tissue invasion can be better appreciated from 3-dimensional modeling. A 49 year old patient with history of endometriosis and persistent pain underwent pre-operative imaging with MRI that was consistent with infiltrating endometriosis...
June 17, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28624664/surgical-outcomes-of-urinary-tract-deep-infiltrating-endometriosis
#2
Basma Darwish, Emanuela Stochino-Loi, Geoffroy Pasquier, Fabrice Dugardin, Guillaume Defortescu, Carole Abo, Horace Roman
OBJECTIVE: To report the outcomes of surgical management of urinary tract endometriosis. DESIGN: Retrospective study based on prospectively recorded data (NCT02294825). DESIGN: Classification: II-3 SETTING: University Tertiary referral center. PATIENTS: 81 women treated for urinary tract endometriosis from July 2009 to December 2015 were included of whom 39 had bladder endometriosis, 31 ureteral endometriosis and 11 both ureteral and bladder endometriosis...
June 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28617258/micronized-palmitoylethanolamide-trans-polydatin-treatment-of-endometriosis-related-pain-a-meta-analysis
#3
Ugo Indraccolo, Salvatore Renato Indraccolo, Fiorenzo Mignini
AIM: To demonstrate clinical effectiveness of micronized palmitoylethanolamide-trans-polydatin combination in reducing endometriotic chronic pelvic pain. Other endometriotic-pains were also assessed. METHODS: Systematic reviews of PubMed, SCIELO, Scopus, and AJOL. Randomized trials and observational studies reporting a visual analogue scale for pain or similar in endometriotic patients were reviewed. A mean improvement of visual analogue scale (or visual analogue scale-like) scores at enrollment and at a three-month follow-up was assessed and interpreted clinically...
April 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28613432/medical-therapy-for-preventing-recurrent-endometriosis-after-conservative-surgery-a-cost-effectiveness-analysis
#4
Bin Wu, Zhiyou Yang, Ruoyan Gai Tobe, Yu Wang
OBJECTIVE: To assess the cost-effectiveness of different strategies, including the gonadotropin-releasing hormone agonist (GnRH-a) and oral contraceptive therapy, for the prevention of endometriosis recurrence after conservative surgery. DESIGN: Cost-effectiveness analysis from a health care perspective. SETTING: Chinese setting represented as a health resource limited setting. POPULATION: patients who undergo laparoscopic or laparotomic conservative surgery for endometriosis...
June 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28609279/to-operate-or-not-to-operate-on-women-with-deep-infiltrating-endometriosis-die-before-in-vitro-fertilization-ivf
#5
REVIEW
Márcia Mendonça Carneiro, Luciana Maria Pyramo Costa, Ivete de Ávila
Deep infiltrating endometriosis (DIE) can cause infertility and pelvic pain. There is little evidence of a clear connection between DIE and infertility, and the absolute benefits of surgery for DIE have not been established. This paper aimed to review the current literature on the effect of surgery for DIE on fertility, pregnancy, and IVF outcomes. Clinicians should bear in mind that a comprehensive clinical history is useful to identify patients at risk for endometriosis, although many women remain asymptomatic...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28597474/zeb1-expression-is-a-potential-indicator-of-invasive-endometriosis
#6
Masataka Furuya, Hirotaka Masuda, Kanako Hara, Hiroshi Uchida, Kenji Sato, Suguru Sato, Hironori Asada, Tetsuo Maruyama, Yasunori Yoshimura, Hidetaka Katabuchi, Mamoru Tanaka, Hideyuki Saya
INTRODUCTION: Although endometriosis is a benign disease, it shares some features with cancers, such as invasiveness and the potential to metastasize. This study sought to investigate the epithelial-mesenchymal transition (EMT) status in human endometriotic lesions. MATERIAL AND METHODS: Thirteen endometriosis patients and ten control women without endometriosis undergoing surgery for benign indications were recruited. We examined the expression of E-cadherin, vimentin, and EMT-induced transcriptional factors, such as Snail and ZEB1, by immunohistochemistry...
June 8, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28576692/utero-abdominal-wall-fistula-after-cesarean-section-in-patient-with-prior-colorectal-resection-for-endometriosis-case-report-and-systematic-review
#7
Chloé Chattot, Patrick Aristizabal, Sofiane Bendifallah, Emile Daraï
Utero-Abdominal Wall Fistula (UAWF) is a very rare complication of cesarean section. We report an unusual case of a UAWF occurring in a 37-year-old woman, 4 years after a cesarean section and previously radical surgery for deep infiltrating endometriosis (DIE) with bowel resection. The patient presented with persistent purulent discharge of the Pfannenstiel scar and had noted that the discharge was blood-stained during menstruation. Magnetic resonance imaging confirmed the diagnosis of UAWF. Surgery was performed by laparotomy and was complicated by a postoperative rectovaginal fistula (RVF) which was successfully treated by the placement of a biological mesh via the vagina route...
May 30, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28573770/re-sonographic-evaluation-of-immobility-of-normal-and-endometriotic-ovary-in-detection-of-deep-endometriosis-b-gerges-c-lu-s-reid-d-chou-t-chang-and-g-condous-ultrasound-obstet-gynecol-2017-49-793-798
#8
https://www.readbyqxmd.com/read/28558521/what-is-known-and-unknown-about-the-association-between-endometriosis-and-sexual-functioning-a-systematic-review-of-the-literature
#9
Giussy Barbara, Federica Facchin, Laura Buggio, Edgardo Somigliana, Nicola Berlanda, Alessandra Kustermann, Paolo Vercellini
It is well known that endometriosis is associated with an increase in the risk of deep dyspareunia, with potential negative effects on global female sexual functioning and couple relationship. The aims of this study were to review the literature on the impact of endometriosis on female sexual functioning and to suggest new avenues for future research and treatment strategies. An electronic database research was performed to identify all the studies on the relation between endometriosis and sexual functioning published in the period 2000 to 2016...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28556124/uterine-adenomyosis-and-infertility-review-of-reproductive-outcome-after-in%C3%A2-vitro-fertilization-and-surgery
#10
REVIEW
Margit Dueholm
This review includes an analysis of the clinical studies evaluating reproductive outcome and adenomyosis, and a review of studies on reproductive outcome and surgical treatment options for adenomyosis. Strict diagnostic criteria and classification of disease are needed for an image diagnosis of adenomyosis. Studies of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) populations and women with surgically treated deep endometriosis have suggested that adenomyosis has a negative impact on reproductive outcome, although there are substantial variations between studies...
June 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28552755/-morbidity-and-functional-long-term-follow-up-of-patients-with-surgical-treatment-of-urinary-tract-endometriosis
#11
T Berling, P-A Bolze, J Berthiller, G Dubernard, G Lamblin, P Paparel, F Golfier
OBJECTIVE: To assess postoperative complications, improvement of pain symptoms and residual urinary functional symptoms after surgery for deep infiltrative endometriosis affecting ureter or bladder. METHODS: Retrospective study of complications (Clavien-Dindo classification), pain (visual analog scale [VAS]) and urinary functional symptoms (Urinary Symptom Profile questionnaire [USP]) of patients surgically treated between 2007 and 2015 in University Hospitals of Lyon...
May 25, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28547097/patient-completed-or-symptom-based-screening-tools-for-endometriosis-a-scoping-review
#12
REVIEW
Eric Surrey, Cathryn M Carter, Ahmed M Soliman, Shahnaz Khan, Dana B DiBenedetti, Michael C Snabes
PURPOSE: The objective of this review was to evaluate existing patient-completed screening questionnaires and/or symptom-based predictive models with respect to their potential for use as screening tools for endometriosis in adult women. Validated instruments were of particular interest. METHODS: We conducted structured searches of PubMed and targeted searches of the gray literature to identify studies reporting on screening instruments used in endometriosis. Studies were screened according to inclusion and exclusion criteria that followed the PICOS (population, intervention, comparison, outcomes, study design) framework...
May 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28545293/the-current-management-of-deep-endometriosis-a-systematic-review
#13
Marina de Paula Andres, Giuliano M Borrelli, Rosanne M Kho, Mauricio S Abrão
INTRODUCTION: Endometriosis is a chronic inflammatory disease that affects young women in reproductive age. It has mainly three different clinical presentations: superficial (peritoneal), ovarian (endometriomas) and deep endometriosis (DE). The last one is the most advanced form of the disease, frequently impairing fertility and harming women's quality of life. EVIDENCE ACQUISITION: We conducted a systematic review on the surgical treatment of DE in the last ten years focusing on its benefits to improve quality of life (QoL) and for pain relief as well as related surgical complications...
May 25, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28541751/a-novel-experimental-model-of-colorectal-endometriosis
#14
Anastasia Prodromidou, Vasilios Pergialiotis, Kitty Pavlakis, Laskarina Maria Korou, Maximos Frountzas, Dimitrios Dimitroulis, Georgios Vaos, Despina N Perrea
PURPOSE: Endometriosis is a disease that affects 6-10% of the female population, mainly women of reproductive age, and causes a variety of cyclic symptoms. Deep infiltrating endometriosis and in particular bowel involvement presents a challenge for modern surgery. To date, there are no experimental animal models in this field, demonstrating experimental induction of endometriosis directly attached to surface of the colon imitating human colorectal endometriosis; hence, the implementation of novel pharmaceutical and surgical strategies for the management of colorectal endometriosis is mainly limited to clinical studies...
May 25, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28510724/relationship-between-the-magnetic-resonance-imaging-appearance-of-adenomyosis-and-endometriosis-phenotypes
#15
Charles Chapron, Claudia Tosti, Louis Marcellin, Mathilde Bourdon, Marie-Christine Lafay-Pillet, Anne-Elodie Millischer, Isabelle Streuli, Bruno Borghese, Felice Petraglia, Pietro Santulli
STUDY QUESTION: What is the relationship between endometriosis phenotypes superficial peritoneal endometriosis (SUP), ovarian endometrioma (OMA), deep infiltrating endometriosis (DIE) and the adenomyosis appearance by magnetic resonance imaging (MRI)? SUMMARY ANSWER: Focal adenomyosis located in the outer myometrium (FAOM) was observed more frequently in women with endometriosis, and was significantly associated with the DIE phenotype. WHAT IS KNOWN ALREADY: An association between endometriosis and adenomyosis has been reported previously, although data regarding the association between MRI appearance of adenomyosis and the endometriosis phenotype are currently still lacking...
May 16, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28508426/the-role-of-transvaginal-ultrasound-in-the-evaluation-of-ureteral-involvement-in-deep-endometriosis
#16
P Carfagna, C De Cicco Nardone, A De Cicco Nardone, A C Testa, G Scambia, R Marana, F De Cicco Nardone
OBJECTIVE: To assess whether routine visualization of the pelvic ureter during transvaginal ultrasonography should be performed in all patients with deep endometriosis candidate to surgery, in order to identify a potential silent ureteral involvement by the disease. METHODS: This was a prospective study of 200 consecutive patients undergoing surgery for deep endometriosis, evaluated between January 2012 and December 2014 at a tertiary endometriosis center at the Department of Obstetrics and Gynecology, Fondazione Policlinico Universitario A...
May 15, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28501371/endometriosis-on-the-uterosacral-ligament-a-marker-of-ureteral-involvement
#17
Raquel Lima, Helizabet Abdalla-Ribeiro, Ana Luisa Nicola, Aline Eras, Anna Lobao, Paulo Ayroza Ribeiro
OBJECTIVE: To evaluate the association between ultrasound measurements of endometriosis nodules on the uterosacral ligament (USL) and the risk of ureteral involvement, as well as to assess whether associations with other ultrasound variables increase the sensitivity and specificity of the diagnosis of ureteral endometriosis. DESIGN: Cross-sectional, observational study. SETTING: University hospital. PATIENT(S): Four hundred sixty-three women with deep infiltrating endometriosis (DIE)...
June 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28489996/cancer-associated-mutations-in-endometriosis-without-cancer
#18
Michael S Anglesio, Nickolas Papadopoulos, Ayse Ayhan, Tayyebeh M Nazeran, Michaël Noë, Hugo M Horlings, Amy Lum, Siân Jones, Janine Senz, Tamer Seckin, Julie Ho, Ren-Chin Wu, Vivian Lac, Hiroshi Ogawa, Basile Tessier-Cloutier, Rami Alhassan, Amy Wang, Yuxuan Wang, Joshua D Cohen, Fontayne Wong, Adnan Hasanovic, Natasha Orr, Ming Zhang, Maria Popoli, Wyatt McMahon, Laura D Wood, Austin Mattox, Catherine Allaire, James Segars, Christina Williams, Cristian Tomasetti, Niki Boyd, Kenneth W Kinzler, C Blake Gilks, Luis Diaz, Tian-Li Wang, Bert Vogelstein, Paul J Yong, David G Huntsman, Ie-Ming Shih
BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benign inflammatory lesions but have cancerlike features such as local invasion and resistance to apoptosis. METHODS: We analyzed deeply infiltrating endometriotic lesions from 27 patients by means of exomewide sequencing (24 patients) or cancer-driver targeted sequencing (3 patients)...
May 11, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28486700/dysregulation-of-the-adam17-notch-signalling-pathways-in-endometriosis-from-oxidative-stress-to-fibrosis
#19
Iñaki González-Foruria, Pietro Santulli, Sandrine Chouzenoux, Francisco Carmona, Charles Chapron, Frédéric Batteux
STUDY QUESTION: Is oxidative stress associated with the A disintegrin and metalloproteases (ADAM) metallopeptidase domain 17 (ADAM17)/Notch signalling pathway and fibrosis in the development of endometriosis? SUMMARY ANSWER: Oxidative stress is correlated with hyperactivation of the ADAM17/Notch signalling pathway and a consequent increase in fibrosis in patients with endometriosis. WHAT IS KNOWN ALREADY: It is nowadays accepted that oxidative stress plays an important role in the onset and progression of endometriosis...
May 9, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28478727/local-upregulation-of-transient-receptor-potential-ankyrin-1-and-transient-receptor-potential-vanilloid-1-ion-channels-in-rectosigmoid-deep-infiltrating-endometriosis
#20
Noémi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Szegedi, József Bódis, Zsuzsanna Helyes, Miklós Koppán
Transient Receptor Potential Vanilloid 1 (TRPV1) and Transient Receptor Potential Ankyrin 1 (TRPA1) expressed mainly by primary sensory neurons function as major nociceptive integrators. They are also present on the rat endometrium in an oestrogen-regulated manner. TRPV1 is upregulated in peritoneal and ovarian endometriosis patients, but there is no information about TRPA1 and their pathophysiological significances. In this study, patients undergoing laparoscopic surgery were investigated: severe dysmenorrhoea due to rectosigmoid deep infiltrating endometriosis ( n = 15), uterine fibroid-induced moderate dysmenorrhoea ( n = 7) and tubal infertility with no pain ( n = 6)...
January 2017: Molecular Pain
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