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Deep endometriosis

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https://www.readbyqxmd.com/read/29456620/endometriosis-and-endometriosis-associated-cancers-new-insights-into-the-molecular-mechanisms-of-ovarian-cancer-development
#1
REVIEW
Amy Dawson, Marta Llauradó Fernandez, Michael Anglesio, Paul J Yong, Mark S Carey
Endometriosis is a fascinating disease that we strive to better understand. Molecular techniques are shedding new light on many important aspects of this disease: from pathogenesis to the recognition of distinct disease variants like deep infiltrating endometriosis. The observation that endometriosis is a cancer precursor has now been strengthened with the knowledge that mutations that are present in endometriosis-associated cancers can be found in adjacent endometriosis lesions. Recent genomic studies, placed in context, suggest that deep infiltrating endometriosis may represent a benign neoplasm that invades locally but rarely metastasises...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29450853/endometriosis-clinical-features-mr-imaging-findings-and-pathologic-correlation
#2
REVIEW
Pietro Valerio Foti, Renato Farina, Stefano Palmucci, Ilenia Anna Agata Vizzini, Norma Libertini, Maria Coronella, Saveria Spadola, Rosario Caltabiano, Marco Iraci, Antonio Basile, Pietro Milone, Antonio Cianci, Giovanni Carlo Ettorre
OBJECTIVE: We illustrate the magnetic resonance imaging (MRI) features of endometriosis. BACKGROUND: Endometriosis is a chronic gynaecological condition affecting women of reproductive age and may cause pelvic pain and infertility. It is characterized by the growth of functional ectopic endometrial glands and stroma outside the uterus and includes three different manifestations: ovarian endometriomas, peritoneal implants, deep pelvic endometriosis. The primary locations are in the pelvis; extrapelvic endometriosis may rarely occur...
February 15, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29448896/circulating-neutrophil-extracellular-traps-are-elevated-in-patients-with-deep-infiltrating-endometriosis
#3
Jordina Munrós, Dolors Tàssies, Joan Carles Reverter, Lidia Martin, Amelia Pérez, Francisco Carmona, María Ángeles Martínez-Zamora
Neutrophil extracellular traps (NETs) have been described to be related to the pathogenesis of inflammatory and autoimmune conditions. Endometriosis is currently considered a chronic inflammatory condition. Therefore, we performed a preliminary case-control study to compare the circulating plasma NET levels in patients with surgically confirmed endometriosis (E group, n = 82) and those of patients without surgical findings of endometriosis (C group, n = 35). Venous blood samples were obtained at the time of surgery...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29444547/laparoscopic-surgery-with-urinary-tract-reconstruction-and-bowel-endometriosis-resection-for-deep-infiltrating-endometriosis
#4
REVIEW
Yoshiaki Ota, Masaaki Andou, Ikuko Ota
Deep infiltrating endometriosis (DIE) is the most severe form of endometriosis. It causes chronic pelvic pain, severe dysmenorrhea, deep dyspareunia, dyschezia, and dysuria, markedly impairing the quality of life of women of reproductive age. A number of randomized controlled trials on surgical and medical treatments to reduce the pain associated with endometriosis have been reported, but few have focused on this in DIE. DIE causes not only pain but also functional invasion to the urinary organs and bowel, such as hydronephrosis and bowel stenosis...
February 14, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29432902/anterior-focal-adenomyosis-and-bladder-deep-infiltrative-is-there-a-link
#5
Louis Marcellin, Pietro Santulli, Sara Bortolato, Cécile Morin, Anne Elodie Millisher, Bruno Borghese, Charles Chapron
STUDY OBJECTIVE: To evaluate the association between bladder deep infiltrating endometriosis (DIE) and anterior focal adenomyosis of the outer myometrium (aFAOM) diagnosed by preoperative magnetic resonance imaging (MRI). DESIGN: An observational, cross-sectional study using prospectively collected data (Canadian Task Force classification II-2). SETTING: Single university tertiary referral center. PATIENTS: All non-pregnant women less than 42-years-old who had undergone complete surgical exeresis of endometriotic lesions...
February 9, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29431849/medical-treatment-in-the-management-of-deep-endometriosis-infiltrating-the-proximal-rectum-and-sigmoid-colon-a-comprehensive-literature-review
#6
Paolo Vercellini, Laura Buggio, Alessandra Borghi, Ermelinda Monti, Umberto Gattei, Maria Pina Frattaruolo
A comprehensive literature review was performed to evaluate the effect of various hormonal therapies, in terms of variations of intestinal and pain complaints and of patient satisfaction with treatment, in women with symptomatic, non-severely sub-occlusive endometriosis infiltrating the proximal rectum and sigmoid colon. A MEDLINE search through PubMed from 2000 to 2018 was conducted to identify all original English language articles published on medical treatment for colorectal endometriosis. Additional reports were identified by systematically reviewing reference lists and using the "similar articles" function in PubMed...
February 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29417283/depleted-lamin-b1-a-possible-marker-of-the-involvement-of-senescence-in-endometriosis
#7
Helena Malvezzi, Bruno Gallani Viana, Cristine Dobo, Renee Zon Filippi, Sérgio Podgaec, Carla Azevedo Piccinato
PROPOSE: Endometriosis is a benign disease characterized by implantation and the growth of endometrial tissue outside the uterine cavity and it shares similarities with cancer. Lamin B1, p16 and p21 play a role on cell cycle regulation, development, cell repair and its activities are related to cancers. Considering the similarities between endometriosis and cancer, the aim of the present cross-sectional study is to detect p16, p21 and Lamin B1 in the ectopic endometrium of patients with endometriosis (n = 8) with eutopic (n = 8) and control endometrium (n = 8) and relate them to the maintenance and development of endometriosis...
February 7, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29402201/similar-characteristics-of-endometrial-and-endometriotic-epithelial-cells
#8
Lutz Konrad, Judith Gronbach, Fabian Horné, Ezekiel O Mecha, Eniko Berkes, Matthias Frank, Stefan Gattenlöhner, Charles O A Omwandho, Frank Oehmke, Hans-Rudolf Tinneberg
Epithelial-mesenchymal transition (EMT) is characterized by the loss of epithelial and acquisition of mesenchymal cell characteristics. Our aim was to assess the epithelial phenotype in the pathogenesis of endometriosis with epithelial and mesenchymal markers. We used 2 structural (keratin-18, -19 [K18, K19]), 1 membrane-associated (mucin-1 [MUC1]), and 2 mesenchymal proteins (vimentin; zinc finger E-box-binding homeobox 1, [ZEB1]) to compare epithelial and mesenchymal characteristics in eutopic endometrium with the 3 endometriotic entities, peritoneal, ovarian, and deep infiltrating endometriosis (DIE)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29398419/the-endometrial-stem-cell-markers-notch-1-and-numb-are-associated-with-endometriosis
#9
Andreas N Schüring, Beatrice Dahlhues, Anna Korte, Ludwig Kiesel, Ulf Titze, Birthe Heitkötter, Christian Ruckert, Martin Götte
Previous studies reported increased expression of the notch pathway-associated protein Musashi-1 in endometriosis. This case-control study investigates an association of the endometrial stem cell markers notch-1 and numb with endometriosis. Fifty-one endometriosis patients and 76 controls were recruited in the IVF unit and tertiary endometriosis referral centre of a university hospital. All subjects underwent transcervical endometrial biopsy and diagnostic laparoscopy. Expression of endometrial notch-1 and numb was assessed by immunostaining and correlated with clinical data...
December 28, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29390219/-combined-treatment-of-endometriosis-radical-yet-gentle
#10
Ibrahim Alkatout, Thilo Wedel, Nicolai Maass
Endometriosis is the second most common benign female genital disease after uterine myoma. This review discusses the management of individual patients. This should take into account the severity of the disease and whether the patient desires to have children. Particular emphasis is laid on the anatomical intersections which, when injured, can lead to persistent damage of the anterior, middle or posterior compartment and are not infrequently the cause of urological and urogynaecological follow-up measures. Typical symptoms of endometriosis include chronic pelvic pain, subfertility, dysmenorrhoea, deep dyspareunia, cyclical bowel or bladder symptoms (e...
February 2018: Aktuelle Urologie
https://www.readbyqxmd.com/read/29385395/mirna-expression-pattern-differs-depending-on-endometriosis-lesion-type
#11
M E Haikalis, J M Wessels, N A Leyland, S K Agarwal, W G Foster
MicroRNA (miRNA), non-coding segments of RNA involved in post-transcriptional regulation of protein expression, are differentially expressed in eutopic endometrium of women with and without endometriosis compared to endometriotic lesions. However, endometriotic lesion types are known to be biochemically distinct and therefore hypothesized that miRNAs are differentially expressed in endometriomas compared to peritoneal and deep-infiltrating lesions. Therefore endometrial biopsies and ectopic implants from women (n = 38) undergoing laparoscopic surgery for chronic pelvic pain were collected...
January 29, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29383962/heterogeneity-of-estrogen-receptor-%C3%AE-and-progesterone-receptor-distribution-in-lesions-of-deep-infiltrating-endometriosis-of-untreated-women-or-during-exposure-to-various-hormonal-treatments
#12
Géraldine Brichant, Patricia Nervo, Adelin Albert, Carine Munaut, Jean-Michel Foidart, Michelle Nisolle
Deep infiltrating endometriosis (DIE) responds variably to hormonal therapy. Mutations in cancer driver genes have been identified in a fraction of the ectopic endometrial epithelial cells, suggesting a functional heterogeneity of these lesions. To evaluate the phenotype heterogeneity of cells in DIE, we measured the expression of estrogen receptor α (ERα) and of progesterone receptor (PR) in DIE of untreated women or under various treatments. We analyzed the luminal epithelial height (LEH), immunoreactive epithelial staining (IRS) and stromal staining intensity (SSI) of ERα and PR...
January 31, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29374618/does-computed-tomography-based-virtual-colonoscopy-improve-the-accuracy-of-preoperative-assessment-based-on-mri-in-women-managed-for-colorectal-endometriosis
#13
Claudia Mehedințu, Lăcrămioara Aurelia Brîndușe, Elvira Brătilă, Michele Monroc, Ebticem Lemercier, Olivier Suaud, Cecile Collet-Savoye, Horace Roman
STUDY OBJECTIVE: To evaluate whether combining Computed Tomography-based virtual Colonoscopy (CTC) with Magnetic Resonance Imaging (MRI) improves preoperative assessment of colorectal endometriosis. DESIGN: Retrospective study using prospectively recorded data (Canadian Task Force classification II-2). SETTING: University tertiary referral center. PATIENTS: Seventy-one women treated for colorectal endometriosis managed between June 2015 and May 2016...
January 25, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29357317/recurrence-in-deep-infiltrating-endometriosis-a-systematic-review-of-the-literature
#14
REVIEW
Manuel Maria Ianieri, Daniele Mautone, Marcello Ceccaroni
Deep infiltrative endometriosis (DIE) is an enigmatic disease that typically impacts the rectovaginal septum, uterosacral ligaments, pararectal space, and vesicouterine fold but can involve the rectum, sigma, ileum, ureters, diaphragm, and other less common sites. Surgery is the treatment of choice as medical management alone commonly fails in controlling the symptoms, although recurrence is very high following surgical treatment. The goal of the current study was to review recurrence rates and identify risk factors related to recurrence following surgery for DIE...
January 18, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29353008/the-isolated-ovarian-endometrioma-a-history-between-myth-and-reality
#15
Caterina Exacoustos, De Felice Giovanna, Alessandra Pizzo, Giulia Morosetti, Lucia Lazzeri, Gabriele Centini, Emilio Piccione, Errico Zupi
STUDY OBJECTIVE: To assess the association between ovarian endometriomas detectable at transvaginal ultrasound (TVS) and other specific extra-ovarian lesions including adhesions, deep infiltrating endometriosis, and adenomyosis. DESIGN: Retrospective observational study (Canadian Task Force classification II-2). SETTING: Two university hospitals. PATIENTS: 255 symptomatic women with at least one ovarian endometrioma found on ultrasound after presentation with pain or irregular menstruation...
January 15, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29337778/pelvic-pain-and-quality-of-life-before-and-after-laparoscopic-bowel-resection-for-rectosigmoid-endometriosis-a-prospective-observational-study
#16
Mads Riiskjær, Axel Forman, Ulrik S Kesmodel, Lars M Andersen, Ken Ljungmann, Mikkel Seyer-Hansen
BACKGROUND: Surgery for rectosigmoid endometriosis carries a substantial risk of short- and long-term complications, which has to be counterbalanced against the potential effect of the procedure. Prospective data are scarce in the field of deep infiltrating endometriosis surgery. OBJECTIVE: The study aimed to assess pelvic pain and quality of life before and after laparoscopic bowel resection for rectosigmoid endometriosis. DESIGN: The study involved prospectively collected data regarding pelvic pain and quality of life before and after surgery...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29332404/bowel-obstruction-secondary-to-deep-infiltrating-endometriosis-of-the-ileum
#17
Marco Antonio Ávila Vergara, Violeta Sánchez Carrillo, Felipe Peraza Garay
Deep infiltrating endometriosis (DIE) of the ileum is an uncommon lesion that may be severe in its clinical presentation. Its diagnosis is challenging in the absence of a gynecological history of endometriosis and because of its anatomical location. We read the article by Sánchez, Candel, and Albarracín, and now report an additional case that was managed urgently.
January 15, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29315418/fertility-outcomes-in-women-experiencing-severe-complications-after-surgery-for-colorectal-endometriosis
#18
C Ferrier, H Roman, Y Alzahrani, E Mathieu d'Argent, S Bendifallah, N Marty, M Perez, C Rubod, P Collinet, E Daraï, M Ballester
STUDY QUESTION: What are the fertility outcomes in women wishing to conceive after experiencing a severe complication from surgical removal of colorectal endometriosis? SUMMARY ANSWER: The pregnancy rate (PR) among women who wished to conceive after a severe complication of surgery for colorectal endometriosis was 41.2% (spontaneously for 80%, after ART procedure for 20%). WHAT IS KNOWN ALREADY: While the long-term benefit of surgery on pain and quality of life is well documented for women with colorectal endometriosis, it exposes women to the risk of severe complications...
January 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29313088/urodynamic-observations-and-lower-urinary-tract-symptoms-associated-with-endometriosis-a-prospective-cross-sectional-observational-study-assessing-women-with-deep-infiltrating-disease
#19
José Anacleto Dutra de Resende Júnior, Claudio Peixoto Crispi, Leon Cardeman, Renata Teles Buere, Márlon de Freitas Fonseca
INTRODUCTION AND HYPOTHESIS: The objective was to assess the association between lower urinary tract disease (LUTD) and the presence of endometriosis at different anatomical sites. METHODS: Our prospective cross-sectional observational study evaluated 138 women with deep infiltrating endometriosis who had undergone preoperative evaluation of urodynamics and detailed assessment of lower urinary tract symptoms between August 2013 and May 2016. After laparoscopy, the anatomical sites of histologically confirmed endometriosis lesions were mapped...
January 8, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29299139/reduced-alternative-splicing-of-estrogen-receptor-alpha-in-the-endometrium-of-women-with-endometriosis
#20
Ying Zhang, Yong Zhang, Chunbo Zhao, Tiantian Yu, Ye Liu, Weihui Shi, Fengtao Shi, Xinmei Liu, Jianzhong Sheng, Hefeng Huang, Hong Xu
Endometriosis is a condition which involves the presence of uterine stroma and glands outside of the uterine cavity and represents one of the most prevalent disorders of the female reproductive tract. The key symptom of endometriosis is pain, including dysmenorrhea, deep dyspareunia, and chronic pelvic pain. As such, endometriosis has significant economic consequences within the healthcare system and can influence the daily quality of life in affected patients. However, the pathophysiology of this disease and the mechanisms in which this condition generates pain are very unclear...
December 15, 2017: Oncotarget
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