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https://www.readbyqxmd.com/read/28923492/rationale-and-design-of-the-atrial-fibrillation-health-literacy-information-technology-trial-af-litt
#1
Emily N Guhl, Courtney L Schlusser, Lori E Henault, Timothy W Bickmore, Everlyne Kimani, Michael K Paasche-Orlow, Jared W Magnani
BACKGROUND: Atrial Fibrillation (AF) is a common cardiac arrhythmia that is challenging for patients and adversely impacts health-related quality of life (HRQoL). Long-term management of AF requires that patients adhere to complex therapies, understand difficult terminology, navigate subspecialty care, and have continued symptom monitoring with the goal of preventing adverse outcomes. Continued interventions to ameliorate the patient experience of AF are essential. DESIGN: The Atrial Fibrillation health Literacy Information Technology Trial (AF-LITT; NCT03093558) is an investigator-initiated, 2-arm randomized clinical trial (RCT)...
September 15, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28922817/children-class-and-the-search-for-security-writing-the-future-in-1930s-britain
#2
Hester Barron, Claire Langhamer
This article is based on 269 essays written in 1937 by Middlesbrough schoolboys aged 12-16 years on the topic 'When I leave school', which were collected by the social research organization Mass Observation. The essays provide a counterpoint to social scientific surveys of ordinary people and allow us to work with the boys' own understandings of the world they inhabited. They offer an alternative lens on a period which, at least in relation to the industrial areas of Britain, is often characterized by poverty and unemployment...
September 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28921759/a-pedagogical-framework-for-facilitating-parents-learning-in-nurse-parent-partnership
#3
Nick Hopwood, Teena Clerke, Anne Nguyen
Nursing work increasingly demands forms of expertise that complement specialist knowledge. In child and family nursing, this need arises when nurses work in partnership with parents of young children at risk. Partnership means working with parents in respectful, negotiated and empowering ways. Existing partnership literature emphasises communicative and relational skills, but this paper focuses on nurses' capacities to facilitate parents' learning. Referring to data from home visiting, day-stay and specialist toddler clinic services in Sydney, a pedagogical framework is presented...
September 17, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28920512/rhythmic-three-part-harmony-the-complex-interaction-of-maternal-placental-and-fetal-circadian-systems
#4
Peter J Mark, Rachael C Crew, Michaela D Wharfe, Brendan J Waddell
From the perspective of circadian biology, mammalian pregnancy presents an unusual biological scenario in which an entire circadian system (i.e., that of the fetus) is embodied within another (i.e., that of the mother). Moreover, both systems are likely to be influenced at their interface by a third player, the placenta. Successful pregnancy requires major adaptations in maternal physiology, many of which involve circadian changes that support the high metabolic demands of the growing fetus. A functional role for maternal circadian adaptations is implied by the effects of circadian disruption, which result in pregnancy complications including higher risks for miscarriage, preterm labor, and low birth weight...
September 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28914138/the-role-of-conscious-attention-in-how-weight-serves-as-an-embodiment-of-importance
#5
Colin A Zestcott, Jeff Stone, Mark J Landau
Inconsistency among findings in the embodied cognition literature suggests a need for theoretical boundary conditions. The current research proposes that conscious attention of a bodily state can moderate its influence on social judgment. Three studies tested this possibility in the case of the demonstrated effect of weight sensations on judgments of an abstract idea's importance. Studies 1 and 2 showed that participants rated a topic as more important when holding a moderately heavy, compared with light, clipboard...
August 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28912618/moral-theological-analysis-of-direct-versus-indirect-abortion
#6
John M Haas
Cases of a vital conflict, where the lives of both the mother and child are at risk during pregnancy, have been the subject of recent vigorous debate. The basic principles put forth in the Ethical and Religious Directives are reviewed, as is the principle of double effect. An illustrative case of severe cardiomyopathy in a pregnant woman is described and it is noted that the principle of double effect would not apply. Counter arguments are noted, focusing on Martin Rhonheimer who posits that in the case of vital conflicts, such as performing a craniotomy on a baby stuck in the birth canal, taking the baby's life does not constitute a direct abortion because moral norms do not apply in the extreme conflict situation where both mother and child will die...
August 2017: Linacre Quarterly
https://www.readbyqxmd.com/read/28906130/human-movement-responses-to-the-rorschach-and-mirroring-activity-an-fmri-study
#7
Luciano Giromini, Donald J Viglione, Jaime A Pineda, Piero Porcelli, David Hubbard, Alessandro Zennaro, Franco Cauda
It has been suggested that the Rorschach human movement (M) response could be associated with an embodied simulation mechanism mediated by the mirror neuron system (MNS). To date, evidence for this hypothesis comes from two electroencephalogram studies and one repetitive transcranial magnetic stimulation study. To provide additional data on this topic, the Rorschach was administered during fMRI to a sample of 26 healthy adult volunteers. Activity in MNS-related brain areas temporally associated with M responses was compared with such activity for other, non-M Rorschach responses...
September 1, 2017: Assessment
https://www.readbyqxmd.com/read/28906026/total-synthesis-and-biological-evaluation-of-spirotryprostatin-a-analogs
#8
Yangmin Ma, Chao Fan, Bin Jia, Pei Cheng, Jia Liu, Yuqiang Ma, Ke Qiao
Based on the spirotryprostatin A structure, a series of compounds belonging to spiro-indolyl diketopiperazine structural class were designed and synthesized, which embody an oxindole with an all-carbon quaternary stereocenter. The total synthesis can efficiently be accessed in a seven-step reaction sequence with 18-28% overall yield from commercially available materials, and a highly enantioselective 1,3-dipolar cycloaddition, N-acylation of the resulting stereochemically complex spiro[pyrrolidin-3,3'-oxindole]s core with Fmoc-L-pro-Cl and spontaneous ring closure upon N-deprotection were obtained...
September 14, 2017: Chirality
https://www.readbyqxmd.com/read/28903666/who-represents-our-group-the-effects-of-prototype-content-on-perceived-status-dispersion-and-social-undermining
#9
Hee Young Kim, Batia M Wiesenfeld
Group identity may be embodied in more typical or extreme member attributes. The present research suggests that individuals' perceptions of the group identity prototype predict their beliefs about the status hierarchy and, in turn, the prevalence of social undermining behavior. Across four studies using both experimental and field data, we find that perceiving that the group prototype is focused on the ideal rather than the central tendency is associated with greater levels of perceived status dispersion and social undermining, and that perceived status dispersion mediates the relationship between members' perception of the group prototype and social undermining behavior...
June 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28903058/insuperable-problems-of-the-genetic-code-initially-emerging-in-an-rna-world
#10
Peter R Wills, Charles W Carter
Differential equations for error-prone information transfer (template replication, transcription or translation) are developed in order to consider, within the theory of autocatalysis, the advent of coded protein synthesis. Variations of these equations furnish a basis for comparing the plausibility of contrasting scenarios for the emergence of specific tRNA aminoacylation, ultimately by enzymes, and the relationship of this process with the origin of the universal system of molecular biological information processing embodied in the Central Dogma...
September 10, 2017: Bio Systems
https://www.readbyqxmd.com/read/28901868/calculable-people-standardising-assessment-guidelines-for-alzheimer-s-disease-in-1980s-britain
#11
Duncan Wilson
This article shows how funding research on Alzheimer's disease became a priority for the British Medical Research Council (MRC) in the late 1970s and 1980s, thanks to work that isolated new pathological and biochemical markers and showed that the disease affected a significant proportion of the elderly population. In contrast to histories that focus on the emergence of new and competing theories of disease causation in this period, I argue that concerns over the use of different assessment methods ensured the MRC's immediate priority was standardising the ways in which researchers identified and recorded symptoms of Alzheimer's disease in potential research subjects...
October 2017: Medical History
https://www.readbyqxmd.com/read/28899256/the-experience-of-feeling-disrespected-a-humanbecoming-perspective
#12
Kim Hawkins
The concept of feeling disrespected was explored using the Parse research method. Ten women living with embodied largeness were asked, "What is the experience of feeling disrespected?" The structure of the living experience was feeling disrespected is mortifying disheartenment arising with disquieting irreverence, as distancing affiliations surface while enduring hardship. The findings provided new knowledge of living quality, advanced nursing practice, and presented future direction for research.
April 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28899139/moving-from-within-the-maternal-the-choreography-of-analytic-eroticism
#13
Dianne Elise
With Kristeva's concept of maternal eroticism (2014) as starting point, the "multiverse" of mother/child erotic sensibilities-the dance of the semiotic chora-is explored and a parallel engagement proposed within the analytic dyad. The dance of psychoanalysis is not the creative product of the patient's mind alone. Clinical work invites, requires, a choreographic engagement by the clinician in interplay with the patient. The clinician's analytic activity is thus akin to choreography: the structuring of a dance, or of a session, expresses an inner impulse brought into narrative form...
February 2017: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/28895019/narrative-self-appropriation-embodiment-alienness-and-personal-responsibility-in-the-context-of-borderline-personality-disorder
#14
Allan Køster
It is often emphasised that persons diagnosed with borderline personality disorder (BPD) show difficulties in understanding their own psychological states. In this article, I argue that from a phenomenological perspective, BPD can be understood as an existential modality in which the embodied self is profoundly saturated by an alienness regarding the person's own affects and responses. However, the balance of familiarity and alienness is not static, but can be cultivated through, e.g., psychotherapy. Following this line of thought, I present the idea that narrativising experiences can play an important role in processes of appropriating such embodied self-alienness...
September 11, 2017: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/28894144/molecular-details-of-secretory-phospholipase-a2-from-flax-linum-usitatissimum-l-provide-insight-into-its-structure-and-function
#15
Payal Gupta, Prasanta K Dash
Secretory phospholipase A2 (sPLA2) are low molecular weight proteins (12-18 kDa) involved in a suite of plant cellular processes imparting growth and development. With myriad roles in physiological and biochemical processes in plants, detailed analysis of sPLA2 in flax/linseed is meagre. The present work, first in flax, embodies cloning, expression, purification and molecular characterisation of two distinct sPLA2s (I and II) from flax. PLA2 activity of the cloned sPLA2s were biochemically assayed authenticating them as bona fide phospholipase A2...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893455/-enjoying-the-kick-locating-pleasure-within-the-drug-consumption-room
#16
Tristan Duncan, Cameron Duff, Bernadette Sebar, Jessica Lee
BACKGROUND: Harm reduction policy and praxis has long struggled to accommodate the pleasures of alcohol and other drug use. Whilst scholars have consistently highlighted this struggle, how pleasure might come to practically inform the design and delivery of harm reduction policies and programs remains less clear. The present paper seeks to move beyond conceptual critiques of harm reduction's 'pleasure oversight' to more focused empirical analysis of how flows of pleasure emerge, circulate and, importantly, may be reoriented in the course of harm reduction practice...
September 8, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28893102/imaging-and-imagining-chronic-obstructive-pulmonary-disease-copd-uruguayans-draw-their-lungs
#17
Megan Wainwright
PURPOSE: This anthropological study investigated what people imagined chronic obstructive pulmonary disease to look like in their lungs, what may be influencing these images and how this imagery shapes embodiment. METHOD: Employing graphic elicitation, in one of multiple ethnographic interviews, participants were asked to draw their lungs: "If we could look inside your chest now, what would we see?" Lung drawings and accompanying narratives and fieldnotes from 14 participants were analyzed for themes and patterns...
September 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28892566/brain-heart-interactions-reveal-consciousness-in-non-communicating-patients
#18
Federico Raimondo, Benjamin Rohaut, Athena Demertzi, Melanie Valente, Denis Engemann, Moti Salti, Diego Fernandez Slezak, Lionel Naccache, Jacobo D Sitt
Objective We here aimed at characterizing heart-brain interactions in patients with disorders of consciousness. We tested how this information impacts data-driven classification between unresponsive and minimally conscious patients. Methods A cohort of 127 patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS, n=70) and minimally conscious state (MCS, n=57) were presented with the 'Local-Global' auditory oddball paradigm, which distinguishes two levels of processing: short-term deviation of local auditory regularities and global long-term rule violations...
September 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28892388/novel-radiolabeled-vanilloid-with-enhanced-specificity-for-human-transient-receptor-potential-vanilloid-1-trpv1
#19
Larry V Pearce, Jihyae Ann, Aeran Jung, Shivaji A Thorat, Brienna K A Herold, Amelework D Habtemichael, Peter M Blumberg, Jeewoo Lee
Transient receptor potential vanilloid 1 (TRPV1) has emerged as a promising therapeutic target. While radiolabeled resiniferatoxin (RTX) has provided a powerful tool for characterization of vanilloid binding to TRPV1, TRPV1 shows 20-fold weaker binding to the human TRPV1 than to the rodent TRPV1. We now describe a tritium radiolabeled synthetic vanilloid antagonist, 1-((2-(4-(methyl-[(3)H])piperidin-1-yl-4-[(3)H])-6-(trifluoromethyl)pyridin-3-yl)methyl)-3-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)urea ([(3)H]MPOU), that embodies improved absolute affinity for human TRPV1 and improved synthetic accessibility...
September 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28891356/benefits-and-burdens-family-caregivers-experiences-of-assistive-technology-at-in-everyday-life-with-persons-with-young-onset-dementia-yod
#20
Torhild Holthe, Rita Jentoft, Cathrine Arntzen, Kirsten Thorsen
BACKGROUND: People with dementia and their family caregivers may benefit from assistive technology (AT), but knowledge is scarce about family carers' (FC) experiences and involvement in the use of AT in everyday life. AIM: To examine the FC roles and experiences with AT as means of supporting people with young onset-dementia (YOD). METHOD: Qualitative interview study with follow-up design. Repeated semi-structured interviews were conducted with 13 FC of people with YOD, participating in an ongoing intervention study investigating the families' use and experiences of AT in everyday life...
September 11, 2017: Disability and Rehabilitation. Assistive Technology
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