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https://www.readbyqxmd.com/read/29334636/impact-of-demographic-factors-on-the-antidepressant-effect-a-patient-level-data-analysis-from-depression-trials-submitted-to-the-pharmaceuticals-and-medical-devices-agency-in-japan
#1
Tetsuo Nakabayashi, Ayako Hara, Hirofumi Minami
A substantial and variable placebo response can cause unreliable findings in clinical trials designed to demonstrate the efficacy of antidepressants, and the high rate of failed trials represents a major obstacle in the development of new drugs for major depressive disorder (MDD). However, the influence of demographic and symptom factors on the antidepressant effect remains to be established. The purpose of this study was to estimate the magnitude of this influence. A patient-level meta-analysis of data from double-blind, randomized, placebo-controlled trials involving the use of antidepressants for adults with MDD was performed...
January 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29334620/evaluation-of-abundance-of-artificial-radionuclides-in-food-products-in-south-korea-and-sources
#2
S H Lee, J S Oh, K B Lee, J M Lee, S H Hwang, M K Lee, E H Kwon, C S Kim, I H Choi, I Y Yeo, J Y Yoon, J M Im
Food samples are collected nationwide from January 2016 to February 2017 and their contents of artificial radionuclides are measured to address the growing concerns regarding the radioactive contamination of food products in Korea. Specifically, 900 food samples are collected for this study and their contents of representative artificial radionuclides 134Cs, 137Cs, 239,240Pu, and 90Sr are analyzed. The analysis shows that the activity concentrations of 137Cs in fish range from minimum detectable activity (MDA) to 340 mBq/kg of fresh weight...
January 12, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29334514/monitoring-depression-rates-in-an-urban-community-use-of-electronic-health-records
#3
Arthur J Davidson, Stanley Xu, Carlos Irwin A Oronce, M Josh Durfee, Emily V McCormick, John F Steiner, Edward Havranek, Arne Beck
OBJECTIVES: Depression is the most common mental health disorder and mediates outcomes for many chronic diseases. Ability to accurately identify and monitor this condition, at the local level, is often limited to estimates from national surveys. This study sought to compare and validate electronic health record (EHR)-based depression surveillance with multiple data sources for more granular demographic subgroup and subcounty measurements. DESIGN/SETTING: A survey compared data sources for the ability to provide subcounty (eg, census tract [CT]) depression prevalence estimates...
January 12, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29334390/smartphone-integrated-optoelectrowetting-sioew-for-on-chip-sample-processing-and-microscopic-detection-of-water-quality
#4
Dongyue Jiang, Seunguk Lee, Sung Woo Bae, Sung-Yong Park
With the increasing capabilities and ubiquity of smartphones and their associated digital cameras, this study presents a smartphone integrated optoelectrowetting (SiOEW) device as a simple, portable tool capable of on-chip water sample preparation and microscopic detection of the target cells in water samples, which significantly reduce the detection time and the labor cost required for water quality monitoring. A commercially available smartphone is used as a low-intensity portable light source to perform optoelectrowetting (OEW)-based microfluidic operations such as droplet transportation, merging, mixing, and immobilization on a hydrophobic detection zone...
January 15, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29334323/development-of-functional-agricultural-products-utilizing-the-new-health-claim-labeling-system-in-japan
#5
Mari Maeda-Yamamoto, Toshio Ohtani
In April 2015, Consumer Affairs Agency of Japan launched a new food labeling system known as "Foods with Function Claims (FFC)." Under this system, the food industry independently evaluates scientific evidence on foods and describes their functional properties. As of May 23, 2017, 1023 FFC containing 8 fresh foods have been launched. Meanwhile, to clarify the health-promoting effects of agricultural products, National Agriculture and Food Research Organization (NARO) implemented the "Research Project on Development of Agricultural Products" and demonstrated the risk reduction of osteoporosis of β-cryptoxanthin rich Satsuma mandarins and the anti-allergic effect of the O-methylated catechin rich tea cultivar Benifuuki...
January 15, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29333470/history-and-perspectives-of-nuclear-medicine-in-myanmar
#6
Win Mar
Nuclear Medicine was established in Myanmar in 1963 by Dr Soe Myint and International Atomic Energy expert Dr R. Hochel at Yangon General Hospital. Nuclear medicine diagnostic and therapeutic services started with Probe Scintillation Detector Systems and rectilinear scanner. In the early stage, many Nuclear Medicine specialists from the International Atomic Energy Agency (IAEA) spent some time in Myanmar and made significant contributions to the development of Nuclear Medicine in our country. The department participated in various IAEA technical cooperation projects and regional cooperation projects...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29332581/cetuximab-and-the-head-and-neck-squamous-cell-cancer
#7
Riccardo Concu, Maria Natalia Dias Soeiro Cordeiro
The head and neck squamous cell cancer (HNSCC) is the most common type of head and neck cancer (more than 90%), and all over the world more than a half million people have been developing this cancer in the last years. This type of cancer is usually marked by a poor prognosis with a really significant morbidity and mortality. Cetuximab received early favor as an exciting and promising new therapy with relatively mild side effect, and due to this received authorization in the 2004 from the European Medicines Agency (EMA) and in the 2006 from the Food and Drug Association (FDA) for the treatment of patients with squamous cell cancer of the head and neck in combination with radiation therapy for locally advanced disease...
January 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29332559/the-relationship-between-domestic-partner-violence-and-suicidal-behaviors-in-an-adult-community-sample-examining-hope-agency-and-pathways-as-protective-factors
#8
Edward C Chang, Elizabeth A Yu, Emma R Kahle, Yifeng Du, Olivia D Chang, Zunaira Jilani, Tina Yu, Jameson K Hirsch
We examined an additive and interactive model involving domestic partner violence (DPV) and hope in accounting for suicidal behaviors in a sample of 98 community adults. Results showed that DPV accounted for a significant amount of variance in suicidal behaviors. Hope further augmented the prediction model and accounted for suicidal behaviors beyond DPV. Finally, we found that DPV significantly interacted with both dimensions of hope to further account for additional variance in suicidal behaviors above and beyond the independent effects of DPV and hope...
October 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332555/victim-empowerment-safety-and-perpetrator-accountability-through-collaboration-a-crisis-to-transformation-conceptual-model
#9
Jacquelyn W White, Holly C Sienkiewicz
This article describes the development of the Victim Empowerment, Safety, and Perpetrator Accountability through Collaboration (VESPAC) model based on a grounded theory analysis of congressionally mandated and permissible purpose areas for grants authorized by the Violence Against Women Act. These areas are reflective of ongoing and emerging needs of victims and agencies serving victims and are rooted in the expertise, insight, and concerns of those who work most closely with victims and perpetrators on a regular basis...
December 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332542/long-journeys-toward-freedom-the-relationship-between-coercive-control-and-space-for-action-measurement-and-emerging-evidence
#10
Nicola Sharp-Jeffs, Liz Kelly, Renate Klein
We report on the development of, and findings from, two scales measuring coercive control and space for action over a period of 3 years in a sample of 100 women who had accessed domestic violence services. We present statistical evidence to show a significant correlation between coercive control and space for action. However, dealing with violence is not a linear process, and support needs to extend beyond being enabled to separate. The scales advance measurement of women's experience of coercive control and, through the space for action scale, document their ability to restore agency and freedom in contexts of relative safety...
February 2018: Violence Against Women
https://www.readbyqxmd.com/read/29332519/integrating-reproductive-health-services-into-intimate-partner-and-sexual-violence-victim-service-programs
#11
Theresa Gmelin, Claire A Raible, Rebecca Dick, Surabhi Kukke, Elizabeth Miller
This study assessed the feasibility of integrating reproductive health services into intimate partner violence/sexual violence (IPV/SV) programs. After a training for victim service agencies on integration of health services, we conducted semistructured interviews with IPV/SV program leadership. Leadership reported advocates were more likely to recognize the need to refer clients to health services, and revealed challenges operationalizing partnerships with health care centers. Training to integrate basic health assessment into victim services may be one way to address women's urgent health needs...
December 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332511/the-process-of-primary-desistance-from-intimate-partner-violence
#12
Kate Walker, Erica Bowen, Sarah Brown, Emma Sleath
This study examined the interaction between structure and agency for individuals in the first or early phase of primary desistance (1 year offending free) from intimate partner violence (IPV). Narrative accounts of perpetrators, survivors, and IPV program facilitators were analyzed using Thematic Analysis. Changes in the self and the contexts, structures, and conditions were necessary to promote desistance. Perpetrators made behavioral and cognitive changes taking on different identities (agentic role) by removing external stressors and instability within the confines of a supportive environment (structural role)...
August 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332321/indicators-and-qualitative-assessment-of-lung-cancer-management-by-health-insurance-review-and-assessment-service-hira-of-korea-in-2015
#13
REVIEW
Chang Dong Yeo, Myoung Kyu Lee, Seung Hyeun Lee, Eun Young Kim, Ik Jae Lee, Heae Surng Park, Yoon Soo Chang
Cancer is the leading cause of death in the Republic of Korea and cancer death accounts for 27.8% of the total deaths, which is not only a social issue but also a concern for the public. Among the cancer death rates, lung cancer mortality account for 34 deaths per 100,000 populations, making it the number one cancer death rate. In a preliminary report on cancer death in 2012, the lung cancer mortality ratio showed the regional variation indicating that there were differences in the qualitative level and the structure among the medical care benefit agency and in the assessment of the treatment process...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29331893/ambient-volatile-organic-compounds-vocs-in-communities-of-the-athabasca-oil-sands-region-sources-and-screening-health-risk-assessment
#14
Md Aynul Bari, Warren B Kindzierski
An investigation of ambient levels and sources of volatile organic compounds (VOCs) and associated public health risks was carried out at two northern Alberta oil sands communities (Fort McKay and Fort McMurray located < 25 km and >30 km from oil sands development, respectively) for the period January 2010-March 2015. Levels of total detected VOCs were comparatively similar at both communities (Fort McKay: geometric mean = 22.8 μg/m3, interquartile range, IQR = 13.8-41 μg/m3); (Fort McMurray: geometric mean = 23...
January 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29331859/development-of-a-method-to-determine-axitinib-lapatinib-and-afatinib-in-plasma-by-micellar-liquid-chromatography-and-validation-by-the-european-medicines-agency-guidelines
#15
Jaume Albiol-Chiva, Josep Esteve-Romero, Juan Peris-Vicente
A method based on micellar liquid chromatography to quantify the tyrosine kinase inhibitors axitinib, lapatinib and afatinib in plasma is reported. The sample pretreatment was a simple 1/5-dilution in a pure micellar solution, filtration and direct injection, without requiring extraction or purification steps. The three drugs were resolved from the matrix in 17min, using an aqueous solution of 0.07M sodium dodecyl sulfate - 6.0% 1-pentanol, buffered at pH7 with 0.01M phosphate salt as mobile phase, running under isocratic mode at 1mL/min through a C18 column...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29331546/clinically-localized-prostate-cancer-aua-astro-suo-guideline-part-ii-recommended-approaches-and-details-of-specific-care-options
#16
Martin G Sanda, Jeffrey A Cadeddu, Erin Kirkby, Ronald C Chen, Tony Crispino, Joann Fontanarosa, Stephen J Freedland, Kirsten Greene, Laurence H Klotz, Danil V Makarov, Joel B Nelson, George Rodrigues, Howard M Sandler, Mary Ellen Taplin, Jonathan R Treadwell
PURPOSE: This guideline is structured to provide a clinical framework stratified by cancer severity to facilitate care decisions and guide the specifics of implementing the selected management options. The summary presented herein represents Part II of the two-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline discussing risk stratification and care options by cancer severity. Please refer to Part I for discussion of specific care options and outcome expectations and management...
January 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29330697/implementation-of-dialectical-behavior-therapy-in-residential-treatment-programs-a-process-evaluation-model-for-a-community-based-agency
#17
Amber M Holbrook, Susan R Hunt, Mary Renata See
Dialectical behavior therapy (DBT) can be challenging to implement in community-based settings. Little guidance is available on models to evaluate the effectiveness or sustainability of training and implementation efforts. Residential programs have much to gain from introduction of evidence-based practices, but present their own challenges in implementation. This paper presents a low-cost process evaluation model to assess DBT training piloted in residential programs. The model targets staff and organizational factors associated with successful implementation of evidence-based practices and matches data collection to the four stages of the DBT training model...
January 12, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29330695/glucosuria-and-all-cause-mortality-among-general-screening-participants
#18
Kunitoshi Iseki, Tsuneo Konta, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Toshiki Moriyama, Masahide Kondo, Chiho Iseki, Tsuyoshi Watanabe
BACKGROUND: Dipstick urine tests are used for general health screening in Japan, but how the test results (e.g., glucosuria) relate to mortality is unknown. METHODS: Subjects participated in a nationwide screening in 2008 in six districts in Japan. We identified those who might have died using the national database of death certificates from 2008 to 2012 (total registered ~ 6 million) and verified candidates with the regional National Health Insurance Agency and public health nurses...
January 12, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29330608/environmental-performance-information-use-by-conservation-agency-staff
#19
Chloe Bradley Wardropper
Performance-based conservation has long been recognized as crucial to improving program effectiveness, particularly when environmental conditions are dynamic. Yet few studies have investigated the use of environmental performance information by staff of conservation organizations. This article identifies attitudinal, policy and organizational factors influencing the use of a type of performance information-water quality information-by Soil and Water Conservation District staff in the Upper Mississippi River Basin region...
January 12, 2018: Environmental Management
https://www.readbyqxmd.com/read/29330172/origins-of-tobacco-harm-reduction-in-the-uk-the-product-modification-programme-1972-1991
#20
Jesse Elias, Pamela M Ling
OBJECTIVE: To better understand the current embrace of long-term nicotine maintenance by British governmental agencies and tobacco harm reduction by several leading British public health organisations, describe the context and deliberations of the UK's first formal tobacco risk reduction programme: 'Product Modification'. METHODS: Analysis of previously secret tobacco industry documents, news archives and Parliamentary debate records. RESULTS: From 1972 to 1991, the British government sought to investigate safer smoking through the 'product modification programme'...
January 12, 2018: Tobacco Control
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