Jun-Ichi Abe, Kyung Ae Ko, Sivareddy Kotla, Yin Wang, Jesus Paez-Mayorga, Ik Jae Shin, Masaki Imanishi, Hang Thi Vu, Yunting Tao, Miguel M Leiva-Juarez, Tamlyn N Thomas, Jan L Medina, Jong Hak Won, Yuka Fujii, Carolyn J Giancursio, Elena McBeath, Ji-Hyun Shin, Liliana Guzman, Rei J Abe, Jack Taunton, Naoki Mochizuki, William Faubion, John P Cooke, Keigi Fujiwara, Scott E Evans, Nhat-Tu Le
The possible association between the membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1) and inflammation has been suggested, but the molecular mechanisms underlying this link, especially during atherogenesis, remain unclear. In endothelial cells (ECs) exposed to disturbed flow (d-flow), p90 ribosomal S6 kinase (p90RSK) bound to MAGI1, causing MAGI1-S741 phosphorylation and sentrin/SUMO-specific protease 2 T368 phosphorylation-mediated MAGI1-K931 deSUMOylation. MAGI1-S741 phosphorylation upregulated EC activation via activating Rap1...
April 4, 2019: JCI Insight