Xiaoxuan Bai, Ying Wang, Xing Luo, Xiaoyi Bao, Xiuzhu Weng, Yuwu Chen, Shan Zhang, Ying Lv, Xinyu Dai, Ming Zeng, Dan Yang, Sining Hu, Ji Li, Yong Ji, Haibo Jia, Bo Yu
BACKGROUND: Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression and the underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis and plaque vulnerability. The present study sought to investigate the mechanism of atherosclerosis progression through tar-induced VSMC necroptosis, a recently described form of necrosis. METHODS: The effect of tar on atherosclerosis progression and VSMC necroptosis was examined in ApoE-/- mice and cultured VSMCs...
January 16, 2024: Cell Communication and Signaling: CCS