keyword
https://read.qxmd.com/read/38229167/cigarette-tar-accelerates-atherosclerosis-progression-via-ripk3-dependent-necroptosis-mediated-by-endoplasmic-reticulum-stress-in-vascular-smooth-muscle-cells
#1
JOURNAL ARTICLE
Xiaoxuan Bai, Ying Wang, Xing Luo, Xiaoyi Bao, Xiuzhu Weng, Yuwu Chen, Shan Zhang, Ying Lv, Xinyu Dai, Ming Zeng, Dan Yang, Sining Hu, Ji Li, Yong Ji, Haibo Jia, Bo Yu
BACKGROUND: Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression and the underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis and plaque vulnerability. The present study sought to investigate the mechanism of atherosclerosis progression through tar-induced VSMC necroptosis, a recently described form of necrosis. METHODS: The effect of tar on atherosclerosis progression and VSMC necroptosis was examined in ApoE-/- mice and cultured VSMCs...
January 16, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/37683503/hypochlorite-activatable-ratiometric-fluorescent-probe-based-on-endoplasmic-reticulum-stress-for-imaging-of-atherosclerosis
#2
JOURNAL ARTICLE
Lijuan Gui, Jun Yan, Junyuan Zhao, Shiya Wang, Yingying Ji, Ji Liu, Jinsheng Wu, Kang Yuan, Heng Liu, Dawei Deng, Zhenwei Yuan
Endoplasmic reticulum (ER) stress can induce reactive oxygen (ROS) generation which is directly associated with the emergence of atherosclerosis. Foam cells could promote atherogenesis by inducing ER stress. To understand hypochlorite (ClO- ) levels in foam cells under ER stress, novel ER-targeted ClO- activatable ratiometric fluorescence probes Rx-NE and Rx-NCE were designed using a classical rhodamine dye and coumarin dye bridge moiety as the fluorescent skeleton. Both Rx-NE and Rx-NCE demonstrated ratiometric detection capabilities for ClO- , with Rx-NCE showing better sensitivity compared to Rx-NE...
August 31, 2023: Biosensors & Bioelectronics
https://read.qxmd.com/read/37321512/systemwide-effects-of-er-intracellular-membrane-contact-site-disturbance-in-primary-endothelial-cells
#3
JOURNAL ARTICLE
Juuso H Taskinen, Hanna Ruhanen, Silke Matysik, Reijo Käkelä, Vesa M Olkkonen
Membrane contact sites (MCS) make up a crucial route of inter-organelle non-vesicular transport within the cell. Multiple proteins are involved in this process, which includes the ER-resident proteins vesicle associated membrane protein associated protein A and -B (VAPA/B) that form MCS between the ER and other membrane compartments. Currently most functional data on VAP depleted phenotypes have shown alterations in lipid homeostasis, induction of ER stress, dysfunction of UPR and autophagy, as well as neurodegeneration...
June 13, 2023: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/36139452/myeloid-tm6sf2-deficiency-inhibits-atherosclerosis
#4
JOURNAL ARTICLE
Wenzhen Zhu, Wenying Liang, Haocheng Lu, Lin Chang, Jifeng Zhang, Y Eugene Chen, Yanhong Guo
Genetic variants in transmembrane 6 superfamily member 2 ( TM6SF2 ), such as E167K, are associated with atherosclerotic cardiovascular disease (ASCVD). Chronic inflammation and lipid-laden macrophage foam cell formation are the central pathogeneses in the development of atherosclerosis. This study was undertaken to illustrate the biological function of TM6SF2 in macrophages and its role during atherosclerosis development. We generated myeloid cell-specific Tm6sf2 knockout mice on ApoE-deficient background (LysM Cre+/ Tm6sf2 fl/fl / ApoE -/- , TM6 mKO) with littermate LysM Cre-/ Tm6sf2 fl/fl / ApoE -/- (Control) mice as controls...
September 15, 2022: Cells
https://read.qxmd.com/read/36108736/transcription-factor-eb-protects-against-endoplasmic-reticulum-stress-in-human-coronary-artery-endothelial-cells
#5
JOURNAL ARTICLE
Michael J Haas, Victoria Feng, Krista Gonzales, Priyanka Bikkina, Marie Angelica Landicho, Arshag D Mooradian
Oxidative stress and endoplasmic reticulum (ER) stress promote atherogenesis while transcription factor EB (TFEB) inhibits atherosclerosis. Since reducing oxidative stress with antioxidants have failed to reduce atherosclerosis possibly because of aggravation of ER stress, we studied the effect of TFEB on ER stress in human coronary artery endothelial cells. ER stress was measured using the secreted alkaline phosphatase assay. Expression and phosphorylation of key mediators of unfolded protein response (UPR)...
September 12, 2022: European Journal of Pharmacology
https://read.qxmd.com/read/35011666/ages-induced-and-endoplasmic-reticulum-stress-inflammation-mediated-regulation-of-glut4-expression-and-atherogenesis-in-diabetes-mellitus
#6
REVIEW
Marisa Passarelli, Ubiratan Fabres Fabres Machado
In recent decades, complex and exquisite pathways involved in the endoplasmic reticulum (ER) and inflammatory stress responses have been demonstrated to participate in the development and progression of numerous diseases, among them diabetes mellitus (DM). In those pathways, several players participate in both, reflecting a complicated interplay between ER and inflammatory stress. In DM, ER and inflammatory stress are involved in both the pathogenesis of the loss of glycemic control and the development of degenerative complications...
December 29, 2021: Cells
https://read.qxmd.com/read/34843981/differential-effects-of-cyclooxygenase-2-cox-2-inhibitors-on-endoplasmic-reticulum-er-stress-in-human-coronary-artery-endothelial-cells
#7
JOURNAL ARTICLE
Michael J Haas, Firas Warda, Priyanka Bikkina, Marie Angelica Landicho, Poonam Kalidas, Shrina Parekh, Arshag D Mooradian
Selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was pulled off the market because of its association with increased risk of adverse cardiovascular effects. The precise underlying mechanism for the differential effects of COX-2 inhibitors on cardiovascular risk is not known. Since endoplasmic reticulum (ER) stress is implicated in atherogenesis, we examined the effects of COX-2 inhibitors on ER stress in primary human coronary artery endothelial cells (HCAEC), human umbilical vein endothelial cells (HUVEC), and human pulmonary artery endothelial cells (HPAEC)...
November 26, 2021: Vascular Pharmacology
https://read.qxmd.com/read/34533042/aging-and-hypercholesterolemia-differentially-affect-the-unfolded-protein-response-in-the-vasculature-of-apoe-mice
#8
JOURNAL ARTICLE
Yuxiang Zhou, Xueping Wan, Kerstin Seidel, Mo Zhang, Jena B Goodman, Francesca Seta, Naomi Hamburg, Jingyan Han
Background Persistent activation of endoplasmic reticulum stress and the unfolded protein response (UPR) induces vascular cell apoptosis, contributing to atherogenesis. Aging and hypercholesterolemia are 2 independent proatherogenic factors. How they affect vascular UPR signaling remains unclear. Methods and Results Transcriptome analysis of aortic tissues from high fat diet-fed and aged ApoE -/- mice revealed 50 overlapping genes enriched for endoplasmic reticulum stress- and UPR-related pathways. Aortae from control, Western diet (WD)-fed, and aged ApoE -/- mice were assayed for (1) 3 branches of UPR signaling (pancreatic ER eIF2-alpha kinase /alpha subunit of the eukaryotic translation initiation factor 1/activating transcription factor 4, inositol-requiring enzyme 1 alpha/XBP1s, activating transcription factor 6); (2) UPR-mediated protective adaptation (upregulation of immunoglobulin heavy chain-binding protein and protein disulfide isomerase); and (3) UPR-mediated apoptosis (induction of C/EBP homologous transcription factor, p-JNK, and cleaved caspase-3)...
September 17, 2021: Journal of the American Heart Association
https://read.qxmd.com/read/34296297/protein-tyrosine-phosphatase-1b-inhibition-improves-endoplasmic-reticulum-stress%C3%A2-impaired-endothelial-cell-angiogenic-response-a-critical-role-for-cell-survival
#9
JOURNAL ARTICLE
Shahenda S Abdelsalam, Mazhar Pasha, Heba El-Gamal, Maram Hasan, Mohamed A Elrayess, Asad Zeidan, Hesham M Korashy, Abdelali Agouni
Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is critically located on the surface of ER membrane, has been found to improve endothelial dysfunction. However, the role of ER stress and its related apoptotic sub‑pathways in PTP1B‑mediated endothelial dysfunction, particularly its angiogenic capacity, have not yet been fully elucidated. Thus, the present study aimed to investigate the impact of PTP1B suppression on ER stress‑mediated impaired angiogenesis and examined the contribution of apoptotic signals in this process...
September 2021: Molecular Medicine Reports
https://read.qxmd.com/read/34136067/btk-promotes-atherosclerosis-by-regulating-oxidative-stress-mitochondrial-injury-and-er-stress-of-macrophages
#10
JOURNAL ARTICLE
Junxiong Qiu, Yuan Fu, Zhiteng Chen, Lisui Zhang, Ling Li, Diefei Liang, Feng Wei, Zhuzhi Wen, Yajing Wang, Shi Liang
Atherosclerosis (AS) is a chronic metabolic disease in arterial walls, characterized by lipid deposition and persistent aseptic inflammation. AS is regarded as the basis of a variety of cardiovascular and cerebrovascular diseases. It is widely acknowledged that macrophages would become foam cells after internalizing lipoprotein particles, which is an initial factor in atherogenesis. Here, we showed the influences of Bruton's tyrosine kinase (BTK) in macrophage-mediated AS and how BTK regulates the inflammatory responses of macrophages in AS...
2021: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/33977048/ketone-body-3-hydroxybutyrate-ameliorates-atherosclerosis-via-receptor-gpr109a-mediated-calcium-influx
#11
JOURNAL ARTICLE
Shu-Jie Zhang, Zi-Hua Li, Yu-Dian Zhang, Jin Chen, Yuan Li, Fu-Qing Wu, Wei Wang, Zong Jie Cui, Guo-Qiang Chen
Atherosclerosis is a chronic inflammatory disease that can cause acute cardiovascular events. Activation of the NOD-like receptor family, pyrin domain containing protein 3 (NLRP3) inflammasome enhances atherogenesis, which links lipid metabolism to sterile inflammation. This study examines the impact of an endogenous metabolite, namely ketone body 3-hydroxybutyrate (3-HB), on a mouse model of atherosclerosis. It is found that daily oral administration of 3-HB can significantly ameliorate atherosclerosis. Mechanistically, 3-HB is found to reduce the M1 macrophage proportion and promote cholesterol efflux by acting on macrophages through its receptor G-protein-coupled receptor 109a (Gpr109a)...
May 2021: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/33675119/hydrogen-sulphide-reduces-hyperhomocysteinaemia-induced-endothelial-er-stress-by-sulfhydrating-protein-disulphide-isomerase-to-attenuate-atherosclerosis
#12
JOURNAL ARTICLE
Shan Jiang, Wenjing Xu, Zhenzhen Chen, Changting Cui, Xiaofang Fan, Jun Cai, Yongsheng Gong, Bin Geng
Hyperhomocysteinaemia (HHcy)-impaired endothelial dysfunction including endoplasmic reticulum (ER) stress plays a crucial role in atherogenesis. Hydrogen sulphide (H2 S), a metabolic production of Hcy and gasotransmitter, exhibits preventing cardiovascular damages induced by HHcy by reducing ER stress, but the underlying mechanism is unclear. Here, we made an atherosclerosis with HHcy mice model by ApoE knockout mice and feeding Pagien diet and drinking L-methionine water. H2 S donors NaHS and GYY4137 treatment lowered plaque area and ER stress in this model...
March 6, 2021: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/33329050/the-anti-atherogenic-role-of-exercise-is-associated-with-the-attenuation-of-bone-marrow-derived-macrophage-activation-and-migration-in-hypercholesterolemic-mice
#13
JOURNAL ARTICLE
Thiago Rentz, Amarylis C B A Wanschel, Leonardo de Carvalho Moi, Estela Lorza-Gil, Jane C de Souza, Renata R Dos Santos, Helena C F Oliveira
An early event in atherogenesis is the recruitment and infiltration of circulating monocytes and macrophage activation in the subendothelial space. Atherosclerosis subsequently progresses as a unresolved inflammatory disease, particularly in hypercholesterolemic conditions. Although physical exercise training has been a widely accepted strategy to inhibit atherosclerosis, its impact on arterial wall inflammation and macrophage phenotype and function has not yet been directly evaluated. Thus, the aim of this study was to investigate the effects of aerobic exercise training on the inflammatory state of atherosclerotic lesions with a focus on macrophages...
2020: Frontiers in Physiology
https://read.qxmd.com/read/33242606/up-regulation-of-thioredoxin-system-by-puerarin-inhibits-lipid-uptake-in-macrophages
#14
JOURNAL ARTICLE
Wenchao Li, Xiaoting Xu, Doudou Dong, Tingwen Lei, Hailong Ou
Cellular oxidative stress promotes lipid accumulation in macrophages during atherogenesis. Puerarin is a natural isoflavone with beneficial effects against oxidation and atherosclerosis. In this study, we investigated the effects of puerarin on lipid uptake and explored the underlying molecular regulation. We found puerarin up-regulated thioredoxin-1 (Trx1) and Trx reductase-1 (TrxR1) expression; it increased TrxR1 activity, cellular thiols contents and decreased oxidized form of Trx1, thus inhibiting cellular ROS generation...
November 23, 2020: Free Radical Biology & Medicine
https://read.qxmd.com/read/32735733/the-microscopic-anatomy-of-endothelial-cells-in-human-atherosclerosis-focus-on-er-and-mitochondria
#15
JOURNAL ARTICLE
Ida Perrotta
Once regarded merely as a bland lipid storage disease consequence of aging, atherosclerosis is currently considered a slow and continuous inflammatory process (partially controllable by treatment) with complex etiology involving a multitude of genetic and environmental risk factors which ultimately result in the formation of the plaque. The vascular endothelium, a monolayer of endothelial cells (ECs), is an important regulatory "organ" critical for cardiovascular homeostasis in health which also contributes significantly to the pathomechanisms of several disease states, including atherosclerosis...
July 31, 2020: Journal of Anatomy
https://read.qxmd.com/read/32384218/high-throughput-profiling-reveals-perturbation-of-endoplasmic-reticulum-stress-related-genes-in-atherosclerosis-induced-by-high-cholesterol-diet-and-the-protective-role-of-vitamin-e
#16
JOURNAL ARTICLE
Perinur Bozaykut, Ruchan Ekren, Osman Ugur Sezerman, Vadim N Gladyshev, Nesrin Kartal Ozer
Formation of atherosclerotic plaques, called atherogenesis, is a complex process affected by genetic and environmental factors. It was proposed that endoplasmic reticulum (ER) stress is an important factor in the pathogenesis of atherosclerosis and that vitamin E affects atherosclerotic plaque formation via its antioxidant properties. Here, we investigated ER stress-related molecular mechanisms in high-cholesterol diet (HCD, 2%)-induced atherosclerosis model and the role of vitamin E supplementation in it, beyond its antioxidant properties...
May 8, 2020: BioFactors
https://read.qxmd.com/read/32323566/dihydrotanshinone-i-attenuates-plaque-vulnerability-in-apoe-mice-role-of-rip3
#17
JOURNAL ARTICLE
Wenwen Zhao, Chunxia Li, Hao Zhang, Qihui Zhou, Xuehong Chen, Yantao Han, Xiuping Chen
AIMS: Vulnerable plaque disruption in advanced atherosclerosis leads to acute thrombus and subsequent myocardial infarction and severely threatens human health. Necroptosis of macrophage involved in the necrotic core is one key factor for plaque vulnerability. Dihydrotanshinone I (DHT) is a natural diterpenoid isolated from Danshen demonstrating effective anti-inflammatory property. It is accepted that inflammation plays a crucial role in the process of atherogenesis. However, whether DHT prevents atherosclerosis is poorly understood...
April 23, 2020: Antioxidants & Redox Signaling
https://read.qxmd.com/read/31706299/terminalia-arjuna-bark-extract-impedes-foam-cell-formation-and-promotes-apoptosis-in-ox-ldl-stimulated-macrophages-by-enhancing-upr-chop-pathway
#18
JOURNAL ARTICLE
Shipra Bhansali, Shivani Khatri, Veena Dhawan
BACKGROUND: Increased macrophage and foam cell apoptosis during early atherogenesis retards plaque progression by impeding foam cell formation, suppressing inflammation and limiting lesion cellularity. Our previous in vitro study in THP1 macrophages demonstrated that Terminalia Arjuna (TA) attenuates dual-specificity phosphatase1 (DUSP1), a key negative regulator of JNK/P38MAPK signaling cascade, the branch also implicated in the UPR (unfolded protein response)-CHOP-mediated apoptotic pathway; however this pathway has not been explored so far in the presence of TA...
November 10, 2019: Lipids in Health and Disease
https://read.qxmd.com/read/31686316/ccaat-enhancer-binding-protein-beta-c-ebp%C3%AE-knockdown-reduces-inflammation-er-stress-and-apoptosis-and-promotes-autophagy-in-oxldl-treated-raw264-7-macrophage-cells
#19
JOURNAL ARTICLE
M D Khurshidul Zahid, Michael Rogowski, Christopher Ponce, Mahua Choudhury, Naima Moustaid-Moussa, Shaikh M Rahman
Atherosclerosis is associated with deregulated cholesterol metabolism and formation of macrophage foam cells. CCAAT/enhancer-binding protein beta (C/EBPβ) is a transcription factor, and its inhibition has recently been shown to prevent atherosclerosis development and foam cell formation. However, whether C/EBPβ regulates inflammation, endoplasmic reticulum (ER) stress, and apoptosis, in macrophage foam cells and its underlying molecular mechanism remains unknown. Here, we investigated the effect of C/EBPβ knockdown on proteins and genes implicated in inflammation, ER stress, apoptosis, and autophagy in macrophage foam cells...
January 2020: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/30987118/endoplasmic-reticulum-stress-a-critical-molecular-driver-of-endothelial-dysfunction-and-cardiovascular-disturbances-associated-with-diabetes
#20
REVIEW
Hatem Maamoun, Shahenda S Abdelsalam, Asad Zeidan, Hesham M Korashy, Abdelali Agouni
Physical inactivity and sedentary lifestyle contribute to the widespread epidemic of obesity among both adults and children leading to rising cases of diabetes. Cardiovascular disease complications associated with obesity and diabetes are closely linked to insulin resistance and its complex implications on vascular cells particularly endothelial cells. Endoplasmic reticulum (ER) stress is activated following disruption in post-translational protein folding and maturation within the ER in metabolic conditions characterized by heavy demand on protein synthesis, such as obesity and diabetes...
April 3, 2019: International Journal of Molecular Sciences
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