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https://www.readbyqxmd.com/read/27926925/dengue-in-the-middle-east-and-north-africa-a-systematic-review
#1
John M Humphrey, Natalie B Cleton, Chantal B E M Reusken, Marshall J Glesby, Marion P G Koopmans, Laith J Abu-Raddad
BACKGROUND: Dengue virus (DENV) infection is widespread and its disease burden has increased in past decades. However, little is known about the epidemiology of dengue in the Middle East and North Africa (MENA). METHODOLOGY / PRINCIPAL FINDINGS: Following Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed available records across MENA describing dengue occurrence in humans (prevalence studies, incidence studies, and outbreak reports), occurrence of suitable vectors (Aedes aegypti and Aedes albopictus), and DENV vector infection rates...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27922196/hiv-prevalence-and-phylogenetic-characteristics-among-entry-travelers-in-xishuangbanna-prefecture-yunnan-province-between-2003-and-2012
#2
Binghui Wang, Yaobo Liang, Yajuan Wang, Yue Feng, Yaping Li, Li Zhang, Qicai Xuan, Jing Miao, Weihong Qin, Xueshan Xia
Xishuangbanna is a popular tourist destination in southern Yunnan Province, bordering with Vietnam and Laos and Myanmar. There are more than 2 million cross-border travelers annually entering China at two land ports, Daluo and Mohan. To clarify the characteristics of HIV-1 prevalence among entry travelers, a retrospective epidemic investigation was conducted. Between 2003 and 2012, 196 among 91,432 entry travelers were detected to be HIV-1-positive, accounting for infection rate of 0.21%. Eighty-one gag-pol gene sequences were obtained for phylogenetic analyses and subsequent recombination analysis...
December 6, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27921276/relationship-between-physician-adjudicated-adverse-events-and-patient-reported-health-related-quality-of-life-in-a-phase-ii-clinical-trial-nct01143402-of-patients-with-metastatic-uveal-melanoma
#3
Thomas M Atkinson, Jennifer L Hay, Alexander Shoushtari, Yuelin Li, Daniel J Paucar, Sloane C Smith, Ragini R Kudchadkar, Austin Doyle, Jeffrey A Sosman, Jorge Fernando Quevedo, Mohammed M Milhem, Anthony M Joshua, Gerald P Linette, Thomas F Gajewski, Jose Lutzky, David H Lawson, Christopher D Lao, Patrick J Flynn, Mark R Albertini, Takami Sato, Karl Lewis, Brian Marr, David H Abramson, Mark Andrew Dickson, Gary K Schwartz, Richard D Carvajal
PURPOSE: Clinical trials commonly use physician-adjudicated adverse event (AE) assessment via the common terminology criteria for adverse events (CTCAE) for decision-making. Patient-reported health-related quality of life (HRQoL) data are becoming more frequent in oncology; however, the relationship between physician-adjudicated AE assessment and HRQoL is understudied. METHODS: Data from a phase II trial (clinicaltrials.gov identifier: NCT01143402) where patients with metastatic uveal melanoma were randomized to receive selumetinib, an oral MEK inhibitor, or chemotherapy were analyzed...
December 5, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27921244/towards-green-oviposition-deterrents-effectiveness-of-syzygium-lanceolatum-myrtaceae-essential-oil-against-six-mosquito-vectors-and-impact-on-four-aquatic-biological-control-agents
#4
Giovanni Benelli, Mohan Rajeswary, Marimuthu Govindarajan
Essential oils (EOs) from plants may be alternative sources of molecules toxic against mosquito vectors of public health relevance. Most of researches in this field focused on EOs as larvicides or ovicides, while limited efforts focused on the exploitation of EOs as oviposition deterrents. In the present study, the larvicidal and oviposition deterrent activity of Syzygium lanceolatum leaf EO was evaluated against six mosquito species, Anopheles stephensi, An. subpictus, Aedes aegypti, Ae. albopictus, Culex quinquefasciatus, and Cx...
December 5, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27921226/the-relationship-between-aerosol-particles-chemical-composition-and-optical-properties-to-identify-the-biomass-burning-contribution-to-fine-particles-concentration-a-case-study-for-s%C3%A3-o-paulo-city-brazil
#5
Regina Maura de Miranda, Fabio Lopes, Nilton Évora do Rosário, Marcia Akemi Yamasoe, Eduardo Landulfo, Maria de Fatima Andrade
The air quality in the Metropolitan Area of São Paulo (MASP) is primarily determined by the local pollution source contribution, mainly the vehicular fleet, but there is a concern about the role of remote sources to the fine mode particles (PM2.5) concentration and composition. One of the most important remote sources of atmospheric aerosol is the biomass burning emissions from São Paulo state's inland and from the central and north portions of Brazil. This study presents a synergy of different measurements of atmospheric aerosol chemistry and optical properties in the MASP in order to show how they can be used as a tool to identify particles from local and remote sources...
December 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27920393/detection-of-wolbachia-in-aedes-albopictus-and-their-effects-on-chikungunya-virus
#6
Noor Afizah Ahmad, Indira Vythilingam, Yvonne A L Lim, Nur Zatil Aqmar A Zabari, Han Lim Lee
Wolbachia-based vector control strategies have been proposed as a means to augment the currently existing measures for controlling dengue and chikungunya vectors. Prior to utilizing Wolbachia as a novel vector control strategy, it is crucial to understand the Wolbachia-mosquito interactions. In this study, field surveys were conducted to screen for the infection status of Wolbachia in field-collected Aedes albopictus The effects of Wolbachia in its native host toward the replication and dissemination of chikungunya virus (CHIKV) was also studied...
December 5, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27919973/bone-targeted-novel-cytotoxic-polybisphosphonate-conjugate-in-castration-resistant-prostate-cancer-a-multicenter-phase-1-study
#7
Camilla Thellenberg-Karlsson, Claes Nyman, Sten Nilsson, René Blom, Marcela Márquez, Enrique Castellanos, Anders R Holmberg
BACKGROUND: Osteodex (ODX) is a cytotoxic bone-targeting polybisphosphonate, intended for treatment of bone metastasis from castration-resistant prostate cancer (CRPC). The primary objective of this study was to describe the tolerability and toxicity of such treatment by defining its maximum tolerated dose (MTD) and dose-limiting toxicity (DLT). PATIENTS AND METHODS: Twenty-eight patients with castration-resistant prostate cancer and confirmed bone metastasis were assigned to seven infusions of ODX every third week, divided in seven ascending dose cohorts...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919901/safety-and-pharmacokinetics-of-cd101-iv-a-novel-echinocandin-in-healthy-adults
#8
Taylor Sandison, Voon Ong, Jonathan Lee, Dirk Thye
CD101 IV is a novel echinocandin with distinctive pharmacokinetic properties that is being developed as a once-weekly treatment for candidemia and invasive candidiasis. CD101 has potent in vitro activity and in vivo efficacy against a broad range of Candida and Aspergillus species. The primary objective of two randomized, double-blind, placebo-controlled, dose-escalation studies in healthy adults was to determine the safety and tolerability of CD101 IV. Sequential cohorts of 8 subjects (n=6, active; n=2, placebo) were administered single (50, 100, 200, 400 mg) or multiple once-weekly (100 mg ×2, 200 mg ×2, 400 mg ×3) doses of CD101 IV infused over 1 hour...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27919756/molecular-identification-and-functional-delineation-of-a-glutathione-reductase-homologue-from-disk-abalone-haliotis-discus-discus-insights-as-a-potent-player-in-host-antioxidant-defense
#9
H M L P B Herath, P D S U Wickramasinghe, S D N K Bathige, R G P T Jayasooriya, Gi-Young Kim, Myoung Ae Park, Chul Kim, Jehee Lee
Glutathione reductase (GSR) is an enzyme that catalyzes the biochemical conversion of oxidized glutathione (GSSG) into the reduced form (GSH). Since the ratio between the two forms of glutathione (GSH/GSSG) is important for the optimal function of GSH to act as an antioxidant against H2O2, the contribution of GSR as an enzymatic regulatory agent to maintain the proper ratio is essential. Abalones are marine mollusks that frequently encounter environmental factors that can trigger the overproduction of reactive oxygen species (ROS) such as H2O2...
December 2, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27918577/control-of-aedes-aegypti-breeding-a-novel-intervention-for-prevention-and-control-of-dengue-in-an-endemic-zone-of-delhi-india
#10
B N Nagpal, Sanjeev Kumar Gupta, Arshad Shamim, Kumar Vikram, Aruna Srivastava, N R Tuli, Rekha Saxena, Himmat Singh, V P Singh, V N Bhagat, N K Yadav, Neena Valecha
BACKGROUND AND OBJECTIVE: The study is based on hypothesis that whether continuous entomological surveillance of Ae. aegypti and simultaneous appropriate interventions in key containers during non-transmission (December-May) months would have any impact on breeding of Aedes and dengue cases during the following transmission months (June-November). The impact of the surveillance and intervention measures undertaken during non-transmission months were assessed by entomological indicators namely container index (CI), house index (HI), pupal index (PI) and breteau index (BI)...
2016: PloS One
https://www.readbyqxmd.com/read/27918261/indoor-development-of-aedes-aegypti-in-germany-2016
#11
Helge Kampen, Stephanie Jansen, Jonas Schmidt-Chanasit, Doreen Walther
In spring 2016, a German traveller returning from Martinique cultivated imported plant offsets in her home, and accidentally bred Aedes aegypti. Thirteen adult mosquito specimens submitted for identification and the traveller were tested for Zika, dengue and chikungunya virus infections, with negative results. The detection of Ae. aegypti by the 'Mueckenatlas' project demonstrates the value of this passive surveillance scheme for potential public health threats posed by invasive mosquitoes in Germany.
November 24, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27918221/neutrophilic-inflammation-in-asthma-mechanisms-and-therapeutic-considerations
#12
Hun Soo Chang, Tae-Hyeong Lee, Ji Ae Jun, Ae Rin Baek, Jong-Sook Park, So My Koo, Yang-Ki Kim, Ho Sung Lee, Choon-Sik Park
Neutrophilic airway inflammation represents a pathologically distinct form of asthma and frequently appears in symptomatic adulthood asthmatics. However, clinical impacts and mechanisms of the neutrophilic inflammation have not been thoroughly evaluated up to date. Areas covered: Currently, distinct clinical manifestations, triggers, and molecular mechanisms of the neutrophilic inflammation (namely Toll-like receptor, Th1, Th17, inflammasome) are under investigation in asthma. Furthermore, possible role of the neutrophilic inflammation is being investigated in respect to the airway remodeling...
December 5, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27917189/first-resistance-mechanisms-characterization-in-glyphosate-resistant-leptochloa-virgata
#13
Ricardo Alcántara-de la Cruz, Antonia M Rojano-Delgado, María J Giménez, Hugo E Cruz-Hipolito, José A Domínguez-Valenzuela, Francisco Barro, Rafael De Prado
Leptochloa virgata (L.) P. Beauv. is an annual weed common in citrus groves in the states of Puebla and Veracruz, Mexico limiting their production. Since 2010, several L. virgata populations were identified as being resistant to glyphosate, but studies of their resistance mechanisms developed by this species have been conducted. In this work, three glyphosate-resistant populations (R8, R14, and R15) collected in citrus orchards from Mexico, were used to study their resistance mechanisms comparing them to one susceptible population (S)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27915155/vertically-oriented-structure-and-its-fracture-behavior-of-the-indonesia-white-pearl-oyster
#14
Guowei Chen, Hongyun Luo, Shunfei Luo, Zhenying Lin, Yue Ma
Structural calcites, aragonites, and the bonding organic network decide the growth, structure and mechanical properties of the mollusk bivalvia shell. Here, it was found out that the calcite prisms together with the coated organics construct another kind of 'brick and mortar' structure similar to the aragonite tablets. The calcite layer can be divided into three sublayers and direct evidences show that the calcite prisms are produced by two methods: nucleation and growing in the first sublayer; or fusing from the aragonites, which is quite different from some previous reports...
November 3, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27914149/erratum-correction-of-funding-source-the-burden-of-cancer-in-korea-during-2012-finding-from-a-prevalence-based-approach
#15
Young Hoon Gong, Seok Jun Yoon, Min Woo Jo, Arim Kim, Young Ae Kim, Jihyun Yoon, Hyeyoung Seo, Dong Woo Kim
This corrects the article on p. S168 in vol. 31, PMID: 27775254.
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27914132/associations-between-soluble-receptor-for-advanced-glycation-end-products-srage-and-s100a12-en-rage-with-mortality-in-long-term-hemodialysis-patients
#16
Eul Sik Jung, Wookyung Chung, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Ji Yong Jung
Hemodialysis (HD) patients experience vascular calcification, ultimately leading to high mortality rates. Previously, we reported associations between soluble receptor for advanced glycation end products (sRAGEs) and extracellular newly identified RAGE-binding protein S100A12 (EN-RAGE) and vascular calcification. Here, we extended our observations, investigating whether these biomarkers may be useful for predicting cardiovascular morbidity and mortality in these subjects. Thus, we evaluated the relationship between sRAGE and S100A12 and mortality in long-term HD patients...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27913833/tight-repulsion-linkage-between-sr36-and-sr39-was-revealed-by-genetic-cytogenetic-and-molecular-analyses
#17
Bosco Chemayek, Urmil K Bansal, Naeela Qureshi, Peng Zhang, William W Wagoire, Harbans S Bariana
The shortening of Aegilops speltoides segment did not facilitate recombination between stem rust resistance genes Sr36 and Sr39 . Robustness of marker rwgs28 for marker-assisted selection of Sr39 was demonstrated. Stem rust resistance genes Sr39 and Sr36 were transferred from Aegilops speltoides and Triticum timopheevii, respectively, to chromosome 2B of wheat. Genetic stocks RL6082 and RWG1 carrying Sr39 on a large and a shortened Ae. speltoides segments, respectively, and the Sr36-carrying Australian wheat cultivar Cook were used in this study...
December 2, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27912204/incremental-diagnostic-value-of-combined-quantitative-and-qualitative-parameters-of-magnetocardiography-to-detect-coronary-artery-disease
#18
Eun-Seok Shin, Yat-Yin Lam, Ae-Young Her, Johannes Brachmann, Friedrich Jung, Jai-Wun Park
BACKGROUND/OBJECTIVES: Magnetocardiography (MCG) has been proposed as a non-invasive and functional technique with high accuracy for diagnosis of myocardial ischemia. This study sought to investigate the incremental diagnostic value of combined quantitative and qualitative parameters of MCG to detect coronary artery disease (CAD). METHODS: Ninety six patients with suspected CAD who underwent coronary angiography were enrolled in the analysis to test the diagnostic accuracy of 2 MCG parameters (a quantitative parameter of the percent change of ST-segment fluctuation score and a qualitative parameter of non-dipole phenomenon)...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27912069/immunogenicity-and-safety-of-southern-hemisphere-quadrivalent-inactivated-influenza-vaccine-a-phase-iii-open-label-study-of-adults-in-brazil
#19
Cristiano A F Zerbini, Rodrigo Ribeiro Dos Santos, Maria Jose Nunes, Jyoti Soni, Ping Li, Varsha K Jain, Opokua Ofori-Anyinam
The World Health Organization influenza forecast now includes an influenza B strain from each of the influenza B lineages (B/Yamagata and B/Victoria) for inclusion in seasonal influenza vaccines. Traditional trivalent influenza vaccines include an influenza B strain from one lineage, but because two influenza B lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza B vaccine-mismatch. Thus, quadrivalent vaccines may potentially reduce the burden of influenza compared with trivalent vaccines...
November 29, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27909554/high-maysin-corn-silk-extract-reduces-body-weight-and-fat-deposition-in-c57bl-6j-mice-fed-high-fat-diets
#20
Eun Young Lee, Sun Lim Kim, Hyeon Jung Kang, Myung Hwan Kim, Ae Wha Ha, Woo Kyoung Kim
BACKGROUNG/OBJECTIVES: The study was performed to investigate the effects and mechanisms of action of high maysin corn silk extract on body weight and fat deposition in experimental animals. MATERIALS/METHODS: A total of 30 male C57BL/6J mice, 4-weeks-old, were purchased and divided into three groups by weight using a randomized block design. The normal-fat (NF) group received 7% fat (diet weight basis), the high-fat (HF) group received 25% fat and 0.5% cholesterol, and the high-fat corn silk (HFCS) group received high-fat diet and high maysin corn silk extract at 100 mg/kg body weight through daily oral administration...
December 2016: Nutrition Research and Practice
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