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er stress and diabetes

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https://www.readbyqxmd.com/read/28797256/selenoprotein-s-a-therapeutic-target-for-diabetes-and-macroangiopathy
#1
REVIEW
Shan-Shan Yu, Jian-Ling Du
Inflammatory response, oxidative stress, and endoplasmic reticulum (ER) stress are important pathophysiological bases of the occurrence and development of diabetes mellitus (DM) and macroangiopathy complications. Selenoprotein S (SELENOS) is involved in the regulation of these mechanisms; therefore, its association with DM and macroangiopathy has gradually received attention from scholars worldwide. SELENOS has different biological functions in different tissues and organs: it exerts antioxidant protection and has anti-ER stress effects in the pancreas and blood vessels, while it promotes the occurrence and development of insulin resistance in the liver, adipose tissue, and skeletal muscle...
August 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28794417/inhibition-of-endoplasmic-reticulum-stress-preserves-the-integrity-of-blood-spinal-cord-barrier-in-diabetic-rats-subjected-to-spinal-cord-injury
#2
Zili He, Shuang Zou, Jiayu Yin, Zhengzheng Gao, Yanlong Liu, Yanqing Wu, Huacheng He, Yulong Zhou, Qingqing Wang, Jiawei Li, Fenzan Wu, Hua-Zi Xu, Xiaofeng Jia, Jian Xiao
The blood-spinal cord barrier (BSCB) plays significance roles in recovery following spinal cord injury (SCI), and diabetes mellitus (DM) impairs endothelial cell function and integrity of BSCS. Endoplasmic reticulum (ER) stress occurs in the early stages of SCI and affects prognosis and cell survival. However, the relationship between ER stress and the integrity of BSCB in diabetic rats after SCI remains unclear. Here we observed that diabetic rats showed increased extravasation of Evans Blue (EB) dye, and loss of endothelial cells and pericytes 1 day after SCI compared to non-diabetic rats...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782427/berberine-improves-diabetic-encephalopathy-through-sirt1-er-stress-pathway-in-db-db-mice
#3
Hong-Ying Li, Xin-Chen Wang, Yu-Min Xu, Na-Chuan Luo, Si Luo, Xu-Yi Hao, Shu-Yi Cheng, Jian-Song Fang, Qi Wang, Shi-Jie Zhang, Yun-Bo Chen
The association between diabetes and dementia has been well-demonstrated by epidemiologic studies. Berberine (BBR) has been reported to ameliorate diabetes and diabetic encephalopathy (DE). However, the mechanism is still unknown. In this study, we employ a diabetic model, db/db mice, to explore whether BBR could protect DE through SIRT1/endoplasmic reticulum (ER) stress pathway. The behavioral results (Morris water maze, Y-maze spontaneous alternation test and fearing condition test) showed that oral administration of BBR (50 mg/kg) improved the learning and memory ability...
August 7, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28780165/the-na-ca-2-exchanger-and-the-plasma-membrane-ca-2-atpase-in-%C3%AE-cell-function-and-diabetes
#4
REVIEW
André Herchuelz, Nathalie Pachera
The rat pancreatic β-cell expresses 6 splice variants of the Plasma Membrane Ca(2+)-ATPase (PMCA) and two splice variants of the Na(+)/Ca(2+) exchanger 1 (NCX1). In the β-cell Na(+)/Ca(2+) exchange displays a high capacity, contributes to both Ca(2+) outflow and influx and participates to the control of insulin release. Gain of function studies show that overexpression of PMCA2 or NCX1 leads to endoplasmic reticulum (ER) Ca(2+) depletion with subsequent ER stress, decrease in β-cell proliferation and β-cell death by apoptosis...
August 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28767442/hydrogen-sulfide-ameliorates-cognitive-dysfunction-in-streptozotocin-induced-diabetic-rats-involving-suppression-in-hippocampal-endoplasmic-reticulum-stress
#5
Wei Zou, Juan Yuan, Zhuo-Jun Tang, Hai-Jun Wei, Wei-Wen Zhu, Ping Zhang, Hong-Feng Gu, Chun-Yan Wang, Xiao-Qing Tang
Diabetes induces impairment in cognitive function. There is substantial evidence that hippocampal endoplasmic reticulum (ER) stress is involved in diabetic cognitive impairment. Hydrogen sulfide (H2S) attenuates the learning and memory decline in experimental Alzheimer's disease and inhibits the hippocampal ER stress in homocysteine-exposed rats. Therefore, this aim of the present work was to investigate whether H2S ameliorates the diabetic cognitive dysfunction involving inhibition of hippocampal ER stress...
July 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765602/arc-is-essential-for-maintaining-pancreatic-islet-structure-and-%C3%AE-cell-viability-during-type-2-diabetes
#6
Wendy M McKimpson, Min Zheng, Streamson C Chua, Jeffrey E Pessin, Richard N Kitsis
Pancreatic β-cell loss through apoptosis is an important disease mechanism in type 2 diabetes. Apoptosis Repressor with CARD (ARC) is a cell death inhibitor that antagonizes multiple death programs. We previously reported that ARC is abundant in pancreatic β-cells and modulates survival of these cells in vitro. Herein we assessed the importance of endogenous ARC in maintaining islet structure and function in vivo. While generalized loss of ARC did not result in detectable abnormalities, its absence in ob/ob mice, a model of type 2 diabetes, induced a striking pancreatic phenotype: marked β-cell death, loss of β-cell mass, derangements of islet architecture, and impaired glucose-stimulated insulin secretion in vivo...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762104/ngf-attenuates-high-glucose-induced-er-stress-preventing-schwann-cell-apoptosis-by-activating-the-pi3k-akt-gsk3%C3%AE-and-erk1-2-pathways
#7
Rui Li, Yanqing Wu, Shuang Zou, Xiaofang Wang, Yiyang Li, Ke Xu, Fanghua Gong, Yanlong Liu, Jian Wang, Yi Liao, Xiaokun Li, Jian Xiao
Diabetic peripheral neuropathy (DPN) is one of the most common and troublesome complications of diabetes mellitus. It has been demonstrated that nerve growth factor (NGF) exerts a pivotal role in the regulation of neuronal growth and the promotion of DPN recovery. However, the exact molecular mechanisms are not well understood. Recent studies have indicated that as a novel therapeutic target, endoplasmic reticulum (ER) stress participates in the onset and progression of DPN. In the present study, it has been demonstrated that NGF prevents the sciatic nerve from degeneration and demyelination in DPN rats...
July 31, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28761152/astragaloside-iv-protects-against-podocyte-injury-via-serca2-dependent-er-stress-reduction-and-ampk%C3%AE-regulated-autophagy-induction-in-streptozotocin-induced-diabetic-nephropathy
#8
Hengjiang Guo, Yi Wang, Xuemei Zhang, Yingjun Zang, Yang Zhang, Li Wang, Hao Wang, Yunman Wang, Aili Cao, Wen Peng
Aberrant endoplasmic reticulum (ER) stress and autophagy are associated with diabetic nephropathy. Here we investigated the effect of astragaloside IV (AS-IV) on the progression of diabetic nephropathy (DN) and the underlying mechanism involving ER stress and autophagy in streptozotocin (STZ)-induced diabetic mice and high glucose (HG)-incubated podocytes. The diabetic mice developed progressive albuminuria and glomerulosclerosis within 8 weeks, which were significantly ameliorated by AS-IV treatment in a dose-dependent manner...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28757338/soluble-epoxide-hydrolase-in-podocytes-is-a-significant-contributor-to-renal-function-under-hyperglycemia
#9
Ahmed Bettaieb, Shinichiro Koike, Ming-Fo Hsu, Yoshihiro Ito, Samah Chahed, Santana Bachaalany, Artiom Gruzdev, Miguel Calvo-Rubio, Kin Sing Stephen Lee, Bora Inceoglu, John D Imig, Jose M Villalba, Darryl C Zeldin, Bruce D Hammock, Fawaz G Haj
BACKGROUND: Diabetic nephropathy (DN) is the leading cause of renal failure, and podocyte dysfunction contributes to the pathogenesis of DN. Soluble epoxide hydrolase (sEH, encoded by Ephx2) is a conserved cytosolic enzyme whose inhibition has beneficial effects on renal function. The aim of this study is to investigate the contribution of sEH in podocytes to hyperglycemia-induced renal injury. MATERIALS AND METHODS: Mice with podocyte-specific sEH disruption (pod-sEHKO) were generated, and alterations in kidney function were determined under normoglycemia, and high-fat diet (HFD)- and streptozotocin (STZ)-induced hyperglycemia...
July 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28747251/serca-control-of-cell-death-and-survival
#10
REVIEW
Elie R Chemaly, Luca Troncone, Djamel Lebeche
Intracellular calcium (Ca(2+)) is a critical coordinator of various aspects of cellular physiology. It is increasingly apparent that changes in cellular Ca(2+) dynamics contribute to the regulation of normal and pathological signal transduction that controls cell growth and survival. Aberrant perturbations in Ca(2+) homeostasis have been implicated in a range of pathological conditions, such as cardiovascular diseases, diabetes, tumorigenesis and steatosis hepatitis. Intracellular Ca(2+) concentrations are therefore tightly regulated by a number of Ca(2+) handling enzymes, proteins, channels and transporters located in the plasma membrane and in Ca(2+) storage organelles, which work in concert to fine tune a temporally and spatially precise Ca(2+) signal...
July 12, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28743992/endotoxemia-mediated-activation-of-acetyltransferase-p300-impairs-insulin-signaling-in-obesity
#11
Jia Cao, Jinghua Peng, Hongying An, Qiyi He, Tatiana Boronina, Shaodong Guo, Morris F White, Philip A Cole, Ling He
Diabetes and obesity are characterized by insulin resistance and chronic low-grade inflammation. An elevated plasma concentration of lipopolysaccharide (LPS) caused by increased intestinal permeability during diet-induced obesity promotes insulin resistance in mice. Here, we show that LPS induces endoplasmic reticulum (ER) stress and protein levels of P300, an acetyltransferase involved in glucose production. In high-fat diet fed and genetically obese ob/ob mice, P300 translocates from the nucleus into the cytoplasm of hepatocytes...
July 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28743549/pyruvate-kinase-m1-interacts-with-a-raf-and-inhibits-endoplasmic-reticulum-stress-induced-apoptosis-by-activating-mek1-erk-pathway-in-mouse-insulinoma-cells
#12
Yuta Horiuchi, Daiki Nakatsu, Fumi Kano, Masayuki Murata
Apoptotic death of pancreatic β cells is a major cause of type 2 diabetes mellitus (T2D) progression. Two isoforms of pyruvate kinase, PKM1 and PKM2, have been reported to participate in cell death in several cell types; however, little is known about their causal pathways in pancreatic β-cell death. We examined whether the suppression of PKM1 or PKM2 affects endoplasmic reticulum (ER) stress-induced apoptosis in a pancreatic β-cell line, MIN6, and Beta-TC-6 and found that knockdown of PKM1, but not of PKM2, leads to the induction of ER stress-induced apoptosis in these cells...
July 22, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28742858/reduction-of-endoplasmic-reticulum-mitochondria-interactions-in-beta-cells-from-patients-with-type-2-diabetes
#13
Charles Thivolet, Guillaume Vial, Romeo Cassel, Jennifer Rieusset, Anne-Marie Madec
Type 2 diabetes develops when beta cells are not able to fulfill insulin needs. The role of the endoplasmic reticulum-mitochondria junction in coordinating the functions of these two organelles throughout the natural history of type 2 diabetes is determinant and may explain the alterations of insulin biosynthesis. Our goal was to study endoplasmic reticulum and mitochondrial interactions in human beta cells from organ donors with type 2 diabetes. Pancreas samples were obtained via the network for pancreatic organ donors with diabetes (nPOD) based on disease status with 12 subjects with type 2 diabetes and 9 non-diabetic controls...
2017: PloS One
https://www.readbyqxmd.com/read/28736253/selective-er-%C3%AE-agonist-alleviates-vascular-endothelial-dysfunction-in-ovariectomized-type-2-diabetic-rats
#14
Seema Bansal, Kanwaljit Chopra
Postmenopausal diabetic women represent a specific risk group with a greater incidence of vascular deficits as compared with age-matched men or non-diabetic women. 17β-estradiol is the mainstay therapy for menopause and associated complications; however, its vasculoprotective effect is lost in women with diabetes. Although, exact mechanism of dichotomous effect of estrogen has not been delineated but it may be due to, differential activation of ER-α and β during disease conditions such as diabetes. Thus main objective of our study was to characterize the specific estrogen receptor which could be selectively targeted to achieve vasculoprotection in postmenopausal diabetic situation...
July 20, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28724746/therapeutic-targeting-tumor-progression-locus-2-tpl2-activating-transcription-factor-4-atf4-chemokine-stromal-cell-derived-factor-%C3%AE-sdf1%C3%AE-axis-suppresses-diabetic-retinopathy
#15
De-Wei Lai, Keng-Hung Lin, Wayne Huey-Herng Sheu, Maw-Rong Lee, Chung-Yu Chen, Wen-Jane Lee, Yi-Wen Hung, Chin-Chang Shen, Tsung-Ju Chung, Shing-Hwa Liu, Meei-Ling Sheu
Rationale: Diabetic retinopathy is characterized by vasopermeability, vascular leakage, inflammation, blood-retinal barrier breakdown, capillary degeneration and neovascularization. However, the mechanisms underlying the association between diabetes and progression retinopathy remain unclear. Objective: Tumor progression locus 2 (TPL2), a serine-threonine protein kinase, exerts a pathological effect on vascular angiogenesis. This study investigated the role of N(ε)-(carboxymethyl)lysine (CML), a major advanced glycation end products, and the involved TPL2-related molecular signals in diabetic retinopathy using models of in vitro and in vivo and human samples...
July 19, 2017: Circulation Research
https://www.readbyqxmd.com/read/28719799/mesencephalic-astrocyte-derived-neurotrophic-factor-manf-a-new-player-in-endoplasmic-reticulum-diseases-structure-biology-and-therapeutic-roles
#16
Yeawon Kim, Sun-Ji Park, Ying Maggie Chen
Mesencephalic astrocyte-derived neurotrophic factor (MANF), a newly identified 18-kDa soluble protein, localizes to the luminal endoplasmic reticulum (ER), whose stress can stimulate MANF expression and secretion. In Drosophila and zebrafish, MANF regulates dopaminergic neuron development. In contrast, in mice, MANF deficiency leads to diabetes and activation of the unfolded protein response. Recent studies in rodent models have demonstrated that MANF mitigates diabetes, exerts neurotrophic function in neurodegenerative disease, protects cardiomyocytes and neurons in myocardial infarction and cerebral ischemia, respectively, and promotes immune cell phenotype switch from proinflammatory macrophages to prorepair anti-inflammatory macrophages...
June 29, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28717166/targeting-cellular-calcium-homeostasis-to-prevent-cytokine-mediated-beta-cell-death
#17
Amy L Clark, Kohsuke Kanekura, Zeno Lavagnino, Larry D Spears, Damien Abreu, Jana Mahadevan, Takuya Yagi, Clay F Semenkovich, David W Piston, Fumihiko Urano
Pro-inflammatory cytokines are important mediators of islet inflammation, leading to beta cell death in type 1 diabetes. Although alterations in both endoplasmic reticulum (ER) and cytosolic free calcium levels are known to play a role in cytokine-mediated beta cell death, there are currently no treatments targeting cellular calcium homeostasis to combat type 1 diabetes. Here we show that modulation of cellular calcium homeostasis can mitigate cytokine- and ER stress-mediated beta cell death. The calcium modulating compounds, dantrolene and sitagliptin, both prevent cytokine and ER stress-induced activation of the pro-apoptotic calcium-dependent enzyme, calpain, and partly suppress beta cell death in INS1E cells and human primary islets...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28711624/curcumin-attenuates-oxidative-stress-induced-nf%C3%AE%C2%BAb-mediated-inflammation-and-endoplasmic-reticulum-dependent-apoptosis-of-splenocytes-in-diabetes
#18
Kahkashan Rashid, Sayantani Chowdhury, Sumit Ghosh, Parames C Sil
The present study was aimed to determine the curative role of curcumin against diabetes induced oxidative stress and its associated splenic complications. Diabetes was induced in the experimental rats via the intraperitoneal administration of a single dose of STZ (65 mg kg(-1) body weight). Increased blood glucose and intracellular ROS levels along with decreased body weight, the activity of cellular antioxidant enzymes and GSH/GSSG ratio were observed in the diabetic animals. Histological assessment showed white pulp depletion and damaged spleen anatomy in these animals...
July 12, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28698385/retinoic-acid-receptor-related-orphan-receptor-alpha-stimulates-adipose-tissue-inflammation-by-modulating-endoplasmic-reticulum-stress
#19
Yin Liu, Yulong Chen, Jinlong Zhang, Yulan Liu, Yanjie Zhang, Zhiguang Su
Adipose tissue inflammation has been linked to metabolic diseases such as obesity and type 2 diabetes. However, the molecules that mediate inflammation in adipose tissue have not been addressed. Although retinoic acid receptor-related orphan receptor alpha (RORα) is known to be involved in the regulation of inflammatory response in some tissues, its role is largely unknown in adipose tissue. Conversely, it is known that endoplasmic reticulum (ER) stress and unfolding protein response (UPR) signaling affect the inflammatory response in obese adipose tissue, but whether RORα regulates these processes remains unknown...
July 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28698383/pancreatic-%C3%AE-cell-protection-from-inflammatory-stress-by-the-endoplasmic-reticulum-proteins-thrombospondin-1-and-mesencephalic-astrocyte-derived-neutrotrophic-factor-manf
#20
Daniel A Cunha, Monia Cito, Fabio A Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladriere, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Decio L Eizirik, Miriam Cnop
Cytokine-induced endoplasmic reticulum (ER) stress is one of the molecular mechanisms underlying pancreatic β-cell demise in type 1 diabetes. Thrombospondin-1 (THBS1) was recently shown to promote β-cell survival during lipotoxic stress. Here we show that ER-localized THBS1 is cytoprotective to rat, mouse and human β-cells exposed to cytokines or thapsigargin-induced ER stress. THBS1 confers cytoprotection by maintaining expression of mesencephalic astrocyte-derived neutrotrophic factor (MANF) in β-cells, and thereby prevents the BH3-only protein BIM-dependent triggering of the mitochondrial pathway of apoptosis...
July 11, 2017: Journal of Biological Chemistry
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