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https://www.readbyqxmd.com/read/28211698/demethylation-of-polymethoxyflavones-by-human-gut-bacterium-blautia-sp-mrg-pmf1
#1
Supawadee Burapan, Mihyang Kim, Jaehong Han
Polymethoxyflavones (PMFs) were biotransformed to various demethylated metabolites in the human intestine by the PMF-metabolizing bacterium, Blautia sp. MRG-PMF1. Because the newly formed metabolites can have different biological activities, the pathways and regioselectivity of PMF bioconversion were investigated. Using an anaerobic in vitro study, 12 PMFs, 5,7-dimethoxyflavone (5,7-DMF), 5-hydroxy-7-methoxyflavone (5-OH-7-MF), 3,5,7-trimethoxyflavone (3,5,7-TMF), 5-hydroxy-3,7-dimethoxyflavone (5-OH-3,7-DMF), 5,7,4'-trimethoxyflavone (5,7,4'-TMF), 5-hydroxy-7,4'-dimethoxyflavone (5-OH-7,4'-DMF), 3,5,7,4'-tetramethoxyflavone (3,5,7,4'-TMF), 5-hydroxy-3,7,4'-trimethoxyflavone (5-OH-3,7,4'-TMF), 5,7,3',4'-tetramethoxyflavone (5,7,3',4'-TMF), 3,5,7,3',4'-pentamethoxyflavone (3,5,7,3',4'-PMF), 5-hydroxy-3,7,3',4'-tetramethoxyflavone (5-OH-3,7,3',4'-TMF), and 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (5,3'-diOH-3,7,4'-TMF), were converted to chrysin, apigenin, galangin, kaempferol, luteolin, and quercetin after complete demethylation...
February 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28208627/phytochemical-analysis-of-agrimonia-pilosa-ledeb-its-antioxidant-activity-and-aldose-reductase-inhibitory-potential
#2
Set Byeol Kim, Seung Hwan Hwang, Hong-Won Suh, Soon Sung Lim
The aim of this study was to determine aldose reductase (AR) inhibitory activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity of compounds from Agrimonia pilosa Ledeb (AP). We isolated agrimoniin (AM), four flavonoid glucosides and two flavonoid glucuronides from the n-butanol fraction of AP 50% methanol extract. In addition to isolated compounds, the AR-inhibitory activity and the DPPH free radical scavenging activity of catechin, 5-flavonoids, and 4-flavonoid glucosides (known components of AP) against rat lens AR (RLAR) and DPPH assay were measured...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28207990/carbonic-anhydrase-and-urease-inhibitory-potential-of-various-plant-phenolics-using-in-vitro-and-in-silico-methods
#3
Abdur Rauf, Muslim Raza, Muhammad Saleem, Ufuk Ozgen, Esen Sezen Karaoglan, Gulin Renda, Erhan Palaska, Ilkay Erdogan Orhan
Plant phenolics are known to display many pharmacological activities. In the current study, eight phenolic compounds [e.g. luteolin 5-O-β-glucoside (1), methyl rosmarinate (2), apigenin (3), vicenin 2 (4), lithospermic acid (5), soyasaponin II (6), rubiadin 3-O-β-primeveroside (7), 4(3,4dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside (8)] isolated from various plant species were tested at 0.2 mM against carbonic anhydrase-II (CA-II) and urease using microtiter assays. Urease inhibition rate for compounds 1-8 ranged between 5...
February 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28194018/protective-role-of-fructokinase-blockade-in-the-pathogenesis-of-acute-kidney-injury-in-mice
#4
Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Shinichiro Inaba, Wei Chen, Carlos Roncal-Jimenez, Myphuong T Le, Michael F Wempe, Tamara Milagres, Takuji Ishimoto, Mehdi Fini, Takahiko Nakagawa, Richard J Johnson, Miguel A Lanaspa
Acute kidney injury is associated with high mortality, especially in intensive care unit patients. The polyol pathway is a metabolic route able to convert glucose into fructose. Here we show the detrimental role of endogenous fructose production by the polyol pathway and its metabolism through fructokinase in the pathogenesis of ischaemic acute kidney injury (iAKI). Consistent with elevated urinary fructose in AKI patients, mice undergoing iAKI show significant polyol pathway activation in the kidney cortex characterized by high levels of aldose reductase, sorbitol and endogenous fructose...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28192760/competitive-binding-experiments-can-reduce-the-false-positive-results-of-affinity-based-ultrafiltration-hplc-a-case-study-for-identification-of-potent-xanthine-oxidase-inhibitors-from-perilla-frutescens-extract
#5
Zhiqiang Wang, Shin Hwa Kwon, Seung Hwan Hwang, Young-Hee Kang, Jae-Yong Lee, Soon Sung Lim
The purpose of this study was to assess the possibility of using competitive binding experiments with ultrafiltration-HPLC analysis to identify potent xanthine oxidase (XO) inhibitors from the Perilla frutescens extract as an attempt to reduce the number of false positive results. To isolate the enzyme-ligand complex from unbound compounds, the P. frutescens extract was either incubated in the absence of XO, in the presence of XO, or with the active site blocked XO before the ultrafiltration was performed. Allopurinaol was used as the XO active site blocker...
February 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28182003/luteolin-selectively-kills-stat3-highly-activated-gastric-cancer-cells-through-enhancing-the-binding-of-stat3-to-shp-1
#6
Shiyu Song, Zhonglan Su, Hui Xu, Mengyuan Niu, Xiufang Chen, Haiyan Min, Bin Zhang, Guibo Sun, Sijing Xie, Hongwei Wang, Qian Gao
The antitumor effect of luteolin, a plant flavonoid, in gastric cancer (GC) cells has not been fully understood. Here we show that luteolin selectively kills STAT3 overactivated GC cells that are often drug resistant. The treatment of luteolin in these GC cells significantly inhibited STAT3 phosphorylation and reduced the expression of STAT3 targeting gene Mcl-1, Survivin and Bcl-xl. Silencing of SHP-1, a protein tyrosine phosphatase, abolished the inhibitory effect of luteolin on STAT3 and cell apoptosis, suggesting that SHP-1 is crucial in luteolin-mediated cellular function...
February 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28167478/the-study-of-polyphenolic-compounds-profile-of-some-rosmarinus-officinalis-l-extracts
#7
Neli-Kinga Olah, Gyongyi Osser, Ramona Flavia Câmpean, Flavia Roxana Furtuna, Daniela Benedec, Lorena Filip, Oana Raita, Daniela Hanganu
The purpose of this study was to compare the polyphenol profile of different Rosemary (Rosmarinus officinalis) extracts obtained from dry and fresh herb and the evaluation of their antioxidant effect. There were studied the polyphenols from hydroalcoholic extracts (1:5- dry plant:solvent) obtained from fresh respectively dry plant and the gemmotherapic extract obtained from fresh plant (1:20- dry plant: solvent). The polyphenol profile was evaluated by UV-Vis spectrophotometry, TLC and HPLC. The total polyphenol respectively flavonoids content were determined by UV-V is spectrophotometry...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28166749/antidiabetic-effects-of-brucea-javanica-seeds-in-type-2-diabetic-rats
#8
Abdulwali Ablat, Mohammed Farouq Halabi, Jamaludin Mohamad, Muhammad Hafiz Husna Hasnan, Hazrina Hazni, Ser-Huy Teh, Jamil A Shilpi, Zulqarnain Mohamed, Khalijah Awang
BACKGROUND: Brucea javanica (B. javanica) seeds, also known as "Melada pahit" in Indo-Malay region are traditionally used to treat diabetes. The objective of this study was to determine antidiabetic, antioxidant and anti-inflammatory effects of B. javanica seeds on nicotinamide (NA)-streptozotocin (STZ) induced type 2 diabetic (T2D) rats and to analyze its chemical composition that correlate with their pharmacological activities. METHODS: A hydroethanolic extract of B...
February 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28152453/two-dimensional-chromatography-based-on-on-line-hplc-dpph-bioactivity-guided-assay-for-the-preparative-isolation-of-analogue-antioxidant-compound-from-arenaria-kansuensis
#9
Yulei Cui, Na Shen, Xiang Yuan, Jun Dang, Yun Shao, Lijuan Mei, Yanduo Tao, Qilan Wang, Zenggen Liu
Traditional Tibetan medicine is important for discovery of drug precursors. However, information about the chemical composition of traditional Tibetan medicine is very limited due to the lack of appropriate chromatographic purification methods. In the present work, A. kansuensis was taken as an example and a novel two-dimensional reversed-phase/hydrophilic interaction liquid chromatography(HILIC) method based on on-line HPLC-DPPH bioactivity-guided assay was developed for the purification of analogue antioxidant compounds with high purity from the extract of A...
January 25, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28145124/three-new-c-alkylated-flavonoids-from-desmodium-oblongum
#10
Yan-Ping Li, Qiu-Fen Hu, Gao-Xiong Rao
Three new C-alkylated flavonoids, 4'-hydroxy-8-isobutyryl-7-methoxy-6-methyl-flavone (1), 4',7-dimethoxy-8-isobutyryl-6-methyl-flavone (2), and 4',7-dimethoxy-8-isobutyryl-flavone (3), together with three know ones luteolin (4), kaemferol (5), and quercetin (6), were isolated from Desmodium oblongum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 showed cytotoxicity against NB4, SHSY5Y, and MCF7 cell lines with IC50 values of 8.5, 6.5, and 7...
February 1, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28126442/a-uhplc-ms-ms-method-for-simultaneous-determination-of-twelve-constituents-from-erigeron-breviscapus-extract-in-rat-plasma-application-to-a-pharmacokinetic-study
#11
Yuanyuan Tian, Qingqian Li, Xinpeng Zhou, Qian Pang, Yuanjin Xu
A rapid, sensitive and specific ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated to simultaneously determine the twelve major bioactive ingredients (neochlorogenic acid, chlorogenic acid, caffeic acid, cynarin, scopoletin, scutellarin, isochlorogenic acid A, apigenin-7-o-glucuronide, isochlorogenic acid C, scutellarein, luteolin, and apigenin) in rat plasma. Gallic acid and wogonoside were used as internal standards (IS1 and IS2). The plasma samples were pretreated and extracted by liquid-liquid extraction and protein precipitation with ethyl acetate-acetonitrile (95:5, v/v)...
January 17, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28121060/combined-application-of-chromatographic-techniques-for-the-separation-of-phenolic-compounds-from-stenoloma-chusanum-ching
#12
Dabing Ren, Binsong Han, Zhongquan Xin, Shasha Ma, Wenbin Liu, Lunzhao Yi
High-speed counter-current chromatography combined with preparative high-performance liquid chromatography was successfully used to separate seven phenolic compounds from Stenoloma chusanum Ching. A biphasic solvent system composed of hexane/ethyl acetate/methanol/water (1:2:1:2, v/v) was used for the first step high-speed counter-current chromatography separation in elution-extrusion mode. A mobile phase composed of acetonitrile (18%) and pure water (82%) was used for further preparative high-performance liquid chromatography purification...
January 25, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28115286/new-aspects-on-the-hepatoprotective-potential-associated-with-the-antioxidant-hypocholesterolemic-and-anti-inflammatory-activities-of-vernonia-condensata-baker
#13
Jucélia Barbosa da Silva, Renata de Freitas Mendes, Vívian Tomasco, Nícolas de Castro Campos Pinto, Luiz Gustavo de Oliveira, Matheus Nehrer Rodrigues, Danielle Maria de Oliveira Aragão, Jair Adriano Kopke de Aguiar, Maria Silvana Alves, Maria Christina Nogueira Marques Castañon, Antônia Ribeiro, Elita Scio
ETHNOPHARMACOLOGICAL RELEVANCE: Vernonia condensata Baker (Asteraceae) is traditionally used in South American Countries as an anti-inflammatory, analgesic and hepatoprotective. AIM OF THE STUDY: This study aimed to investigate the in vivo hepatoprotective and antioxidant, and the in vitro anti-inflammatory activities of the ethyl acetate partition (EAP) from the ethanolic extract of this medicinal plant leaves. MATERIALS AND METHODS: For the in vivo hepatoprotective activity, rats were pretreated orally for seven days with vehicle, silymarin 100mg/kg or EAP 50, 100 and 200mg/kg...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28115273/ablation-of-akt2-prevents-paraquat-induced-myocardial-mitochondrial-injury-and-contractile-dysfunction-role-of-nrf2
#14
Shuyi Wang, Xiaoling Zhu, Lize Xiong, Jun Ren
Paraquat is a quaternary nitrogen herbicide triggering oxidative stress, mitochondrial damage and multi-organ injuries including hearts. To date, effective measure to combat paraquat toxicity is still lacking. Recent evidence has revealed a role for Akt in cardiac homeostasis. To this end, this study was designed to examine the role of Akt2 in acute paraquat exposure-induced cardiac contractile and mitochondrial injury using a unique murine model of Akt2 knockout. Cardiac contractile and intracellular Ca(2+) properties were evaluated...
January 20, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28113103/two-dietary-polyphenols-fisetin-and-luteolin-reduce-inflammation-but-augment-dna-damage-induced-toxicity-in-human-rpe-cells
#15
Maria Hytti, Dora Szabó, Niina Piippo, Eveliina Korhonen, Paavo Honkakoski, Kai Kaarniranta, Goran Petrovski, Anu Kauppinen
Plant-derived polyphenols are known to possess anti-inflammatory and antioxidant effects. In recent years, several studies have investigated their potential benefits for treating chronic diseases associated with prolonged inflammation and excessive oxidative stress, such as age-related macular degeneration (AMD). Previously, two polyphenols, fisetin and luteolin, have been reported to increase the survival of retinal pigment epithelial (RPE) cells suffering from oxidative stress as well as decreasing inflammation but the benefits of polyphenol therapy seem to depend on the model system used...
January 9, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28112209/luteolin-improves-cardiac-dysfunction-in-heart-failure-rats-by-regulating-sarcoplasmic-reticulum-ca-2-atpase-2a
#16
Wenjing Hu, Tongda Xu, Pei Wu, Defeng Pan, Junhong Chen, Jing Chen, Buchun Zhang, Hong Zhu, Dongye Li
We previously found that luteolin (Lut) appeared to improve the contractility of cardiomyocytes during ischemia/reperfusion in rats. The enhancement was associated with the alteration in sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a). This finding prompted us to consider if the mechanism worked in heart failure (HF). We studied the regulation of SERCA2a by Lut in failing cardiomyocytes and intact heart of rats. Improvement of contractility and the mechanisms centered on SERCA2a were studied in isolated cardiomyocytes and intact heart...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28112175/luteolin-7-diglucuronide-attenuates-isoproterenol-induced-myocardial-injury-and-fibrosis-in-mice
#17
Bing-Bing Ning, Yong Zhang, Dan-Dan Wu, Jin-Gang Cui, Li Liu, Pei-Wei Wang, Wen-Jian Wang, Wei-Liang Zhu, Yu Chen, Teng Zhang
Myocardial injury and ensuing fibrotic alterations impair normal heart architecture and cause cardiac dysfunction. Oxidative stress has been recognized as a key player in the pathogenesis of cardiac injury and progression of cardiac dysfunction, and promoting fibrosis. In the current study we investigated whether luteolin-7-diglucuronide (L7DG), a naturally occurring antioxidant found in edible plants, could attenuate isoproterenol (ISO)-induced myocardial injury and fibrosis in mice and the underlying mechanisms...
January 23, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28111945/in-vivo-selective-capture-and-rapid-identification-of-luteolin-and-its-metabolites-in-rat-livers-by-molecularly-imprinted-solid-phase-microextraction
#18
Die Gao, Dan-Dan Wang, Qian Zhang, Feng-Qing Yang, Zhi-Ning Xia, Qi-Hui Zhang, Chun-Su Yuan
A method based on molecularly imprinted solid-phase microextraction (MIP-SPME) coupled with liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (QTOF-MS/MS) was developed for the detection of luteolin and its metabolites in vivo. The MIP-SPME fibers were first fabricated by dopamine and silane, and then luteolin MIPs-coated fibers were successfully prepared using luteolin, acrylamide (AM), and ethylene glycol dimethacrylate (EGDMA) as the template, functional monomer and cross-linker, respectively...
February 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28110189/anticancer-activity-of-baicalein-and-luteolin-studied-in-colorectal-adenocarcinoma-lovo-cells-and-in-drug-resistant-lovo-dx-cells
#19
Anna Palko-Labuz, Kamila Sroda-Pomianek, Anna Uryga, Edyta Kostrzewa-Suslow, Krystyna Michalak
Due to the type-specific diversity of cancer cells, an analysis and elucidation of molecular mechanisms responsible for anticancer properties of biologically active compounds are essential. Plant-derived polyphenolic compounds such as flavonoids may be useful in cancer chemoprevention or treatment because they influence diverse molecular pathways in cancer cells. In these studies anticancer activity of natural occurring flavones, baicalein and luteolin was investigated in colon cancer cells LoVo and in their drug resistant subline LoVo/Dx...
January 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28109916/polyphenolic-enriched-extract-of-cassia-glauca-lamk-improves-streptozotocin-induced-type-1-diabetes-linked-with-partial-insulin-resistance-in-rats
#20
V P Veerapur, V Pratap, B S Thippeswamy, P Marietta, P Bansal, P V Kulkarni, V H Kulkarni
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally Cassia glauca (CG) has been used to treat diabetes. AIM OF THE STUDY: The study was undertaken to evaluate anti-diabetic and antioxidant activity of poly phenolic enriched extract of CG in standardized streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: The effect of ethanol (CGE) and water (CGW) extracts of CG (200 and 400mg/kg) treatment were evaluated in STZ (50mg/kg, iv) induced diabetic rats...
January 18, 2017: Journal of Ethnopharmacology
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