keyword
MENU ▼
Read by QxMD icon Read
search

luteolin

keyword
https://www.readbyqxmd.com/read/29329836/fermented-apulian-table-olives-effect-of-selected-microbial-starters-on-polyphenols-composition-antioxidant-activities-and-bioaccessibility
#1
Isabella D'Antuono, Angelica Bruno, Vito Linsalata, Fiorenza Minervini, Antonella Garbetta, Maria Tufariello, Giovanni Mita, Antonio F Logrieco, Gianluca Bleve, Angela Cardinali
The effects of fermentation by autochthonous microbial starters on phenolics composition of Apulian table olives, Bella di Cerignola (BDC), Termite di Bitetto (TDB) and Cellina di Nardò (CEL) were studied, highlighting also the cultivars influence. In BDC with starter, polyphenols amount doubled compared with commercial sample, while in TDB and CEL, phenolics remain almost unchanged. The main phenolics were hydroxytyrosol, tyrosol, verbascoside and luteolin, followed by hydroxytyrosol-acetate detected in BDC and cyanidine-3-glucoside and quercetin in CEL...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29327407/bioavailability-and-metabolism-of-rosemary-infusion-polyphenols-using-caco-2-and-hepg2-cell-model-systems
#2
Mariem Achour, Saad Saguem, Beatriz Sarriá, Laura Bravo, Raquel Mateos
BACKGROUND: Rosmarinus officinalis is an aromatic plant used in folk medicine due to the therapeutic properties associated to its phenolic composition, rich in rosmarinic acid (RA) and caffeic acid (CA). To better understand the bioactivity of these compounds, their absorption and metabolism were assessed in human Caco-2 and HepG2 cells, as small intestine and liver models, respectively, using RA and CA standards, as well as a rosemary infusion and ferulic acid (FA). RESULTS: Test compounds were partially up-taken and metabolized by Caco-2 and HepG2 cells, although higher metabolization rate was observed after hepatic incubation than intestinal...
January 12, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29317180/oral-administration-of-fisetin-promotes-the-induction-of-hippocampal-long-term-potentiation-in%C3%A2-vivo
#3
Wen-Bin He, Kazuho Abe, Tatsuhiro Akaishi
To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fisetin, quercetin, luteolin and myricetin) tested, only fisetin significantly facilitated the induction of hippocampal LTP. The effect of oral fisetin was abolished by intracerebroventricular injection of U0126, an agent that was previously found to inhibit its effect in hippocampal slices in vitro...
December 20, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29315633/preferential-adsorption-of-flavonoids-from-peanut-shell-by-amino-modified-fe3-o4-nanoparticles-mnp-nh2
#4
Xuexiao Cao, Meng Wang, Lili Sun, Xiaoliang Ren, Gaosheng Pei
BACKGROUND: The highly selective capture of individual components of complex systems such as Chinese medicine extracts is a great challenge. With the rapid development of nanoscience, magnetic materials have attracted increased attention as suitable candidates for use in drug transport vehicles. RESULTS: In this work, amino-modified Fe3 O4 nanoparticles (MNP-NH2 ) have been synthesized and successfully used to selectively isolate Luteolin, a type of flavonoid, from peanut shell, coupled with high-performance liquid chromatography (HPLC)...
January 9, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29286098/luteolin-inhibits-pancreatitis%C3%A2-induced-acinar%C3%A2-ductal-metaplasia-proliferation-and-epithelial%C3%A2-mesenchymal-transition-of-acinar-cells
#5
Xince Huang, Pravin Avinash Bhugul, Gang Fan, Tingting Ye, Shihao Huang, Shengjie Dai, Bicheng Chen, Mengtao Zhou
Luteolin, a flavone, has been demonstrated to have anti‑cancer properties. In the current study, the effects of luteolin on certain carcinogenesis‑associated changes induced by pancreatitis, which are significant risk factors for pancreatic cancer, were investigated. Male six‑week‑old C57BL6 mice used in the current study were divided into three groups; the control group, acute pancreatitis group and luteolin group. Intra‑peritoneal injection of cearulein was performed in the acute pancreatitis group and luteolin group to induce acute pancreatitis whereas the luteolin group received intra‑peritoneal injection of luteolin...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29277460/aconitum-alkaloids-the-major-components-of-aconitum-species-affect-expression-of-multidrug-resistance-associated-protein-2-and-breast-cancer-resistance-protein-by-activating-the-nrf2-mediated-signalling-pathway
#6
Jin-Jun Wu, Yuan-Feng Zhu, Zhen-Zhen Guo, Yan-Mei Lou, Shu-Gui He, Yang Guan, Li-Jun Zhu, Zhong-Qiu Liu, Lin-Lin Lu, Liang Liu
BACKGROUND: Aconitum alkaloids from Aconitum species are often used to treat arthritis and rheumatic diseases but have the drawback of high toxicity. Identifying their pharmacokinetic behaviour is important for the safe clinical application of Aconitum species. Efflux transporters (ETs), including P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP), have important functions in regulating the pharmacokinetic behaviours of drugs and in herb-herb or herb-drug interactions (HDIs)...
December 8, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29277227/phenolic-antioxidants-of-foxtail-and-little-millet-cultivars-and-their-inhibitory-effects-on-%C3%AE-amylase-and-%C3%AE-glucosidase-activities
#7
P M Pradeep, Yadahally N Sreerama
Evaluation of phenolic contents and their in vitro bioactivities of six diverse cultivars of foxtail and little millets revealed that their total phenolic content ranged from 19.42 to 24.12 µmol ferulic acid equivalents/g. The soluble fraction accounted for more than 80% of the total phenolic and flavonoid contents. Ferulic, caffeic and sinapic acids were the predominant phenolic acids, and luteolin and kaempferol were major flavonoids in the soluble fractions of millets. However, ferulic and p-coumaric acids were abundant in the bound fractions...
May 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29230827/occurrence-of-variable-levels-of-health-promoting-fruit-compounds-in-horn-shaped-italian-sweet-pepper-varieties-assessed-by-a-comprehensive-approach
#8
Giuseppe Mennella, Antonietta D'Alessandro, Gianluca Francese, Daniela Fontanella, Mario Parisi, Pasquale Tripodi
BACKGROUND: Cultivated pepper is a rich source of diverse bioactive compounds with potential properties related to the prevention of major degenerative and proliferative diseases. In the present study, 15 sweet pepper varieties highly appreciated on the Italian market, were assessed for variation in the content of ascorbic acid, isoprenoids, flavonoids, morpho-agronomic performances and molecular diversity. RESULTS: The collection under study showed a wide variability for all traits considered...
December 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29225663/high-throughput-detection-of-antioxidants-in-mulberry-fruit-using-correlations-between-high-resolution-mass-and-activity-profiles-of-chromatographic-fractions
#9
Ye Ji Park, Si Hyun Seong, Min Sun Kim, Sang Wan Seo, Mee Ree Kim, Hyun Sik Kim
Background: Plant extracts contain a huge variety of pharmacologically active substances. Conventionally, various chromatographic methods must be applied several times to purify functional compounds to measure their functional activity. However, conventional purification methods are time-consuming and expensive due to the laborious purification process. Recently, a high-throughput discovery method that replaces such time-consuming purification processes was introduced; this method uses 15 T ultra-high-resolution Fourier transform ion cyclotron resonance mass spectrometry (15 T FT-ICR MS) and a high-throughput screening method...
2017: Plant Methods
https://www.readbyqxmd.com/read/29225189/luteolin-attenuates-airway-inflammation-by-inducing-the-transition-of-cd4-cd25-to-cd4-cd25-regulatory-t-cells
#10
Seung-Hyung Kim, Evelyn Saba, Bok-Kyu Kim, Won-Kyung Yang, Yang-Chun Park, Han Jae Shin, Chang Kyun Han, Young Cheol Lee, Man Hee Rhee
Regulatory T cells (Th2) play an important role in autoimmunity and have been shown to exert anti-inflammatory effects in allergic asthma. Mouse model of airway inflammation was used to examine the suppressive activity of luteolin-induced CD4+CD25+ regulatory T cells (Tregs) in vivo. In this study, BALB/c mice were sensitized with ovalbumin antigen (OVA) by aerosol challenge. Then, various biological processes were examined, including airway eosinophilia; mucus hypersecretion; elevation of OVA-specific IgE, expression of Th2 cytokines and chemokine levels; expression of eotaxin 2 and CCR3; and airway hyper responsiveness (AHR)...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29222780/oligodendrocyte-progenitor-cell-cultures-a-model-to-screen-neurotrophic-compounds-for-myelin-repair
#11
Massimo Barbierato, Stephen D Skaper, Laura Facci
The protocol presented in this chapter covers the application of rat cortical oligodendrocyte progenitor cells cultured under conditions of differentiation for the evaluation of agents with potential trophic activity, that is, which are capable of promoting maturation under such conditions. As an example we have chosen a co-ultramicronized N-palmitoylethanolamine/luteolin composite, a formulation described in the literature as possessing anti-inflammatory, neuroprotective, and neuroregenerative actions.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29220817/infrared-spectroscopy-of-flavones-and-flavonols-reexamination-of-the-hydroxyl-and-carbonyl-vibrations-in-relation-to-the-interactions-of-flavonoids-with-membrane-lipids
#12
Goran Baranović, Suzana Šegota
Detailed vibrational assignments for twelve flavonoids (seven flavones (flavone, 3- and 5-hydroxyflavone, chrysin, apigenin, fisetin and luteolin) and five flavonols (galangin, kaempferol, quercetin, morin and myricetin)) have been made based on own and reported experimental data and calculations at the B3LYP/6-31+G(d,p) level of theory. All the molecules are treated in a uniform way by using the same set of redundancy-free set of internal coordinates. A generalized harmonic mode mixing is used to corroborate the vibrational characteristics of this important class of molecules...
December 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29217536/correction-to-metabolic-disposition-of-luteolin-is-mediated-by-the-interplay-of-udp-glucuronosyltransferases-and-catechol-o-methyltransferases-in-rats
#13
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29217268/novel-in-vitro-and-in-silico-insights-of-the-multi-biological-activities-and-chemical-composition-of-bidens-tripartita-l
#14
Sengul Uysal, Asli Ugurlu, Gokhan Zengin, Mehmet Cengiz Baloglu, Yasemin Celik Altunoglu, Adriano Mollica, Luisa Custodio, Nuno R Neng, José M F Nogueira, M Fawzi Mahomoodally
Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) and bioactive compound(s) docked against target enzymes using in silico methods...
December 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29216879/anti-diabetic-potential-of-sapium-ellipticum-hochst-pax-leaf-extract-in-streptozotocin-stz-induced-diabetic-wistar-rats
#15
Osasenaga Macdonald Ighodaro, Oluseyi Adeboye Akinloye
BACKGOUND: Ethnobatanical survey associates Sapium ellipticum (SE) with antidiabetic usage among other medicinal functions in different parts of Africa. More importantly, previous studies on the plant extract in our laboratory showed that SE has significant effects on the activities of carbohydrate metabolizing enzymes such as glucokinase, glucose-6-phosphatase, α-amylase and α-glucosidase. In view of these, the anti-diabetic potential of the plant leaf extract in streptozotocin (STZ)-induced diabetes rat model (Wistar strain) was examined...
December 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29209349/regulation-of-fig-ficus-carica-l-fruit-color-metabolomic-and-transcriptomic-analyses-of-the-flavonoid-biosynthetic-pathway
#16
Ziran Wang, Yuanyuan Cui, Alexander Vainstein, Shangwu Chen, Huiqin Ma
Combined metabolomic and transcriptomic analyses were carried out with fig cultivar Green Peel and its color mutant "Purple Peel." Five and twenty-two metabolites were identified as having significantly different contents between fruit peels of the two cultivars at young and mature stages, respectively. Cyanidin O-malonylhexoside demonstrated a 3,992-fold increase in the mature purple peel, the first identification of a major cyanidin in fig fruit; cyanidin 3-O-glucoside, cyanidin O-malonylhexoside O-hexoside and cyanidin-3,5-O-diglucoside were upregulated 100-fold, revealing the anthocyanins underlying the purple mutation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29207088/liposome-encapsulated-luteolin-showed-enhanced-antitumor-efficacy-to-colorectal-carcinoma
#17
Guixia Wu, Jing Li, Jinqiao Yue, Shuying Zhang, Kurexi Yunusi
Luteolin is a falconoid compound that is present in various types of plants and possesses remarkable potential as a chemopreventive agent. However, the poor aqueous solubility of luteolin limits its clinical application. In the present study, an approach towards chemoprevention was explored using liposomes to deliver luteolin, and the antitumor efficacy was investigated in colorectal carcinoma. The present findings demonstrated that luteolin was efficiently encapsulated into liposomes with an encapsulation efficiency as high as 90%...
November 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29199881/phytochylomicron-as-a-dual-nanocarrier-for-liver-cancer-targeting-of-luteolin-in-vitro-appraisal-and-pharmacodynamics
#18
Yosra Sr Elnaggar, Manal A Elsheikh, Ossama Y Abdallah
AIM: A novel luteolin (LUT) loaded dual bionanocarrier 'phytochylomicron' was elaborated to allow LUT injectable delivery and liver cancer targeting. METHODS: LUT-phospholipid complex was prepared and loaded into chylomicron nanocarrier. Then phytochylomicron underwent physicochemical characterization, cell culture and pharmacodynamics studies on a new liver-tumor model. RESULTS: Phytochylomicron showed sustained release pattern with minimum drug leakage until reaching the liver...
December 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29198743/apigenin-and-luteolin-display-differential-hypocholesterolemic-mechanisms-in-mice-fed-a-high-fat-diet
#19
Tsz Yan Wong, Yan Qin Tan, Shu-Mei Lin, Lai K Leung
Hypercholesterolemia is a major risk factor in the development of atherosclerosis. High blood cholesterol can be the result of increased biosynthesis or reduced elimination of cholesterol in the system. Increased consumption of fruits and vegetables is recommended for patients suffering from hypercholesterolemia. The plant food flavones apigenin and luteolin have previously been shown to suppress the synthesis of cholesterol in human hepatocytes. The effectiveness of these two flavones in controlling blood cholesterol was examined in a mouse model in the present study...
November 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29196613/protective-effect-of-luteolin-against-renal-ischemia-reperfusion-injury-via-modulation-of-pro-inflammatory-cytokines-oxidative-stress-and-apoptosis-for-possible-benefit-in-kidney-transplant
#20
Yan Liu, Baoxin Shi, Yi Li, Hui Zhang
BACKGROUND The acceptances and long-term outcomes of the renal transplantations are seriously jeopardized by inflammatory responses and damage to tissues. The present study intended to explicate the pharmacological effect of luteolin (LT) in renal ischemia/reperfusion (I/R) injury and the possible mechanism of action of LT. MATERIAL AND METHODS The effect of LT on the level of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in the homogenates of kidney tissues of male Swiss albino mice was determined after I/R injury...
December 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
keyword
keyword
37134
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"