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https://www.readbyqxmd.com/read/28912714/anti-inflammatory-and-analgesic-effects-of-polygonum-orientale-l-extracts
#1
Kai-Jun Gou, Rui Zeng, Yan Dong, Qi-Qi Hu, Huang-Wan-Yin Hu, Katherine G Maffucci, Qi-Ling Dou, Qing-Bo Yang, Xu-Hua Qin, Yan Qu
Background and Purpose:Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, is a Traditional Chinese Medicinal and has long been used for rheumatic arthralgia and rheumatoid arthritis. However, no pharmacological and mechanism study to confirm these clinic effects have been published. In this investigation, the anti-inflammatory, analgesic effects and representative active ingredient compounds of P. orientale have been studied. Methods: Dried small pieces of the stems and leaves of P. orientale were decocted with water and partitioned successively to obtain ethyl acetate and ethyl ether extract of P...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28895237/a-comprehensive-characterisation-of-rosemary-tea-obtained-from-rosmarinus-officinalis-l-collected-in-a-sub-humid-area-of-tunisia
#2
Mariem Achour, Raquel Mateos, Maha Ben Fredj, Ali Mtiraoui, Laura Bravo, Saad Saguem
INTRODUCTION: Rosemary (Rosmarinus officinalis L.) is an aromatic plant common in Tunisia and it is widely consumed as a tea in traditional cuisine and in folk medicine to treat various illnesses. Currently, most research efforts have been focused on rosemary essential oil, alcoholic and aqueous extracts, however, little is reported on rosemary infusion composition. OBJECTIVE: To investigate compounds present in rosemary tea obtained from Rosmarinus officinalis L...
September 12, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28885001/two-are-better-than-one-halloysite-nanotubes-supported-surface-imprinted-nanoparticles-using-synergy-of-metal-chelating-and-low-pka-boronic-acid-monomers-for-highly-specific-luteolin-binding-under-neutral-condition
#3
Shucheng Liu, Jinxin Liu, Jianming Pan, Jialu Luo, Xiangheng Niu, Tao Zhang, Fengxian Qiu
Surface-imprinted nanoparticles with double recognition (DM-MIPs) are fabricated onto halloysite nanotubes (HNTs) for highly specific separation of natural flavone luteolin (LTL) under neutral condition. Specifically, a two-step strategy via consecutive surface-initiated atom transfer radical polymerization (SI-ATRP) is employed to introduce inherent recognition of molecular imprinting and reversible covalent affinity of boronic acid ligands and immobilized Zn(2+) into DM-MIPs. First, Zn(2+)-immobilized poly(vinyl imidazole) (PVLD) shell based on the HNTs via the first SI-ATRP is prepared to capture LTL by metal chelating...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28884178/screening-of-potential-anti-adipogenic-effects-of-phenolic-compounds-showing-different-chemical-structure-in-3t3-l1-preadipocytes
#4
Andrea Mosqueda-Solís, Arrate Lasa, Saioa Gómez-Zorita, Itziar Eseberri, Catalina Picó, María P Portillo
This study was designed to analyze the anti-adipogenic effect of fifteen phenolic compounds from various chemical groups in 3T3-L1 pre-adipocytes. Cells were treated with 25 μM, 10 μM or 1 μM of apigenin, luteolin, catechin, epicatechin, epigallocatechin, genistein, daizein, naringenin, hesperidin, quercetin, kaempferol, resveratrol, vanillic acid, piceatannol and pterostilbene for 8 days. At 25 μM lipid accumulation was reduced by all the compounds, with the exception of catechin, epicatechin and epigallocatechin...
September 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28878808/luteolin-quercetin-genistein-and-quercetagetin-inhibit-the-effects-of-lipopolysaccharide-obtained-from-porphyromonas-gingivalis-in-h9c2-cardiomyoblasts
#5
Gloria Gutiérrez-Venegas, Alfredo Torras-Ceballos, Juan Arturo Gómez-Mora, Berenice Fernández-Rojas
BACKGROUND: One of the microorganisms from dental plaque associated with severe inflammatory responses in infectious endocarditis is Porphyromonas gingivalis. It is a Gram-negative bacteria harvested from chronic periodontitis patients. Lipopolysaccharide (LPS) obtained from P. gingivalis promotes the expressions of interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha (TNF-α). Flavonoids are thought to participate in processes that control inflammation, such as the expression of cyclooxygenase-2 (COX-2)...
2017: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/28875706/dietary-flavonoids-and-acarbose-synergistically-inhibit-alpha-glucosidase-and-lower-postprandial-blood-glucose
#6
Bowei Zhang, Xia Li, Wenlong Sun, Yan Xing, Zhilong Xiu, Chunlin Zhuang, Yuesheng Dong
The inhibition of porcine pancreatic α-amylase and mammalian α-glucosidase by sixteen individual flavonoids was determined. The IC50 values for baicalein, (+)-catechin, quercetin, and luteolin were 74.1 ± 5.6, 175.1 ± 9.1, 281.2 ± 19.2, and 339.4 ± 16.3 μM, respectively, against α-glucosidase. The IC50 values for apigenin and baicalein were 146.8 ± 7.1 and 446.4 ± 23.9 μM, respectively, against α-amylase. The combination of baicalein, quercetin or luteolin with acarbose showed synergistic inhibition, and the combination of (+)-catechin with acarbose showed antagonistic inhibition of α-glucosidase...
September 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28872689/metabolic-interactions-between-acetaminophen-paracetamol-and-two-flavonoids-luteolin-and-quercetin-through-in-vitro-inhibition-studies
#7
Lei Cao, Awewura Kwara, David J Greenblatt
OBJECTIVES: Excessive exposure to acetaminophen (APAP, paracetamol) can cause liver injury through formation of a reactive metabolite that depletes hepatic glutathione and causes hepatocellular oxidative stress and damage. Generation of this metabolite is mediated by Cytochrome-P450 (CYP) isoforms, mainly CYP2E1. A number of naturally occurring flavonoids can mitigate APAP-induced hepatotoxicity in experimental animal models. Our objective was to determine the mechanism of these protective effects and to evaluate possible human applicability...
September 5, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28868116/bio-effectiveness-of-the-main-flavonoids-of-achillea-millefolium-in-the-pathophysiology-of-neurodegenerative-disorders-a-review
#8
REVIEW
Fatemeh Ayoobi, Ali Shamsizadeh, Iman Fatemi, Alireza Vakilian, Mohammad Allahtavakoli, Gholamhossein Hassanshahi, Amir Moghadam-Ahmadi
The Achillea millefolium L. (Yarrow) is a common herb which is widely being used, worldwide. Achillea is being used for treatment of many disorders since centuries. It is considered safe for supplemental use and flavonoids such as kaempferol, luteolin and apigenin are of main constituents present in Achillea. Most of both antioxidant and anti-inflammatory properties of this herb have been attributed to its flavonoid content. Oxidative and inflammatory processes play important roles in pathogenesis of neurodegenerative diseases...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28864954/comparison-of-the-trace-elements-and-active-components-of-lonicera-japonica-flos-and-lonicera-flos-using-icp-ms-and-hplc-pda
#9
Yueran Zhao, Deqiang Dou, Yueqiu Guo, Yue Qi, Jun Li, Dong Jia
Thirteen trace elements and active constituents of 40 batches of Lonicera japonica flos and Lonicera flos were comparatively studied using inductively coupled plasma mass-spectrometry (ICP-MS) and high-performance liquid chromatography-photodiode array (HPLC-PDA). The trace elements were (24)Mg, (52)Cr, (55)Mn, (57)Fe, (60)Ni, (63)Cu, (66)Zn, (75)As, (82)Se, (98)Mo, (114)Cd, (202)Hg, and (208)Pb, and the active compounds were chlorogenic acid, 3,5-O-dicaffeoylquinc acid, 4,5-O-dicaffeoylquinc acid, luteolin-7-O-glucoside, and 4-O-caffeoylquinic acid...
September 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28858228/health-promoting-effects-of-thymus-herba-barona-thymus-pseudolanuginosus-and-thymus-caespititius-decoctions
#10
Andrea F Afonso, Olívia R Pereira, Rodrigo T Neto, Artur M S Silva, Susana M Cardoso
Thymus herba-barona, Thymus pseudolanuginosus, and Thymus caespititius decoctions were screened for their phenolic constituents, along with their potential antioxidant, anti-inflammatory, and antibacterial activities. The total phenolic compounds in the extracts of the three plants ranged from 236.0 ± 26.6 mgGAE/g (T. caespititus) to 293.0 ± 30.5 mgGAE/g of extract (T. pseudolanuginosus), being particularly rich in caffeic acid derivatives, namely rosmarinic acid and its structural isomers, as well as flavones, such as luteolin-O-glucuronide...
August 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28856944/inhibition-of-human-cytochromes-p450-2a6-and-2a13-by-flavonoids-acetylenic-thiophenes-and-sesquiterpene-lactones-from-pluchea-indica-and-vernonia-cinerea
#11
Supattra Boonruang, Khanistha Prakobsri, Phisit Pouyfung, Ekaruth Srisook, Aruna Prasopthum, Pornpimol Rongnoparut, Songklod Sarapusit
The human liver cytochrome P450 (CYP) 2A6 and the respiratory CYP2A13 enzymes play role in nicotine metabolism and activation of tobacco-specific nitrosamine carcinogens. Inhibition of both enzymes could offer a strategy for smoking abstinence and decreased risks of respiratory diseases and lung cancer. In this study, activity-guided isolation identified four flavonoids 1-4 (apigenin, luteolin, chrysoeriol, quercetin) from Vernonia cinerea and Pluchea indica, four hirsutinolide-type sesquiterpene lactones 5-8 from V...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28840692/-studies-on-chemical-constituents-of-clinopodium-chinense
#12
Ling-Tian Wang, Zhong-Hao Sun, Ming-Liang Zhong, Hai-Feng Wu, Hai-Jing Zhang, Nai-Liang Zhu, Gui-Bo Sun, Xiao-Xia Ye, Xu-Dong Xu, Yin-di Zhu, Jun-Shan Yang
Twenty-eight compounds were isolated and purified from Clinopodium chinense by Sephedax LH-20, ODS, MCI and preparative HPLC. Their structures were identified as apigenin (1), apigenin-7-O-β-D-glucopyranoside (2), apigenin-7-O-β-D-glucuronopyranoside (3), thellungianol (4), apigenin-7-O-β-D-rutinoside (5), luteolin (6), luteolin-4'-O-β-D-glucopyranoside (7), apigenin-7-O-β-D-pyranglycuronate butyl ester (8), luteolin-7-O-β-D-rutinoside (9), luteolin-7-O-β-D-noehesperidoside (10), acacetin (11), acacetin-7-O-β-D-glucuronopyranoside (12), buddleoside (13), naringenin (14), pruning (15), nairutin (16), isosakuranetin (17), isosakuranin (18), didymin (19), hesperidin (20), kaempferol (21), quercetin (22), kaempferol-3-O-α-L-rahmnoside (23), p-hydroxycinnamic acid (24), caffeic acid (25), cis-3-[2-[1-(3,4-dihydroxy-phenyl)-1 -hydroxymethyl]-1,3-ben-zodioxol-5-yl]-(E)-2-propenoic acid (26), mesaconic acid (27), gentisic acid 5-O-β-D-(6'-salicylyl)-glucopyranoside (28)...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28840299/antimicrobial-and-antioxidant-activities-of-the-extract-and-fractions-of-tetradenia-riparia-hochst-codd-lamiaceae-leaves-from-brazil
#13
Ana Claudia A M Fernandez, Maurício F Rosa, Carla M M Fernandez, Wanessa C Bortolucci, Ulisses Z Melo, Vera L D Siqueira, Diógenes A G Cortez, José E Gonçalves, Giani A Linde, Zilda C Gazim
Tetradenia riparia (Lamiaceae) is native to Central Africa popularly known as myrrh, used in folk medicine to treat various diseases like malaria, gastroenteritis, and tropical skin disease. This research was to evaluate the antioxidant and antibacterial activities of the crude extract (CE) and fractions (FR) of the T. riparia by classical chromatography. The CE of T. riparia leaves was submitted to column chromatographic fractionation to obtain four fractions of the interest, which were identified by nuclear magnetic resonance and gas chromatograph coupled to mass spectrum: FR-I (abieta-7,9(11)-dien-13-β-ol), FR-II (Ibozol), FR-III (8 (14), 15-sandaracopimaradiene-2α, 18-diol and 8 (14), 15-sandaracopimaradiene-7α, 18-diol), and FR-IV (Astragalin, Boronolide and Luteolin)...
August 24, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28833875/characterization-of-phenolic-compounds-in-green-and-red-oak-leaf-lettuce-cultivars-by-uhplc-dad-esi-qtof-ms-using-ms-e-scan-mode
#14
Gabriela E Viacava, Sara I Roura, Luis A Berrueta, Carmen Iriondo, Blanca Gallo, Rosa M Alonso-Salces
Lettuce (Lactuca sativa) is one of the most popular leafy vegetables in the world and constitutes a major dietary source of phenolic compounds with health promoting properties. In particular, the demand for green and red oak-leaf lettuces have considerably increased in the last years but few data on their polyphenol composition is available. Moreover, the utilization of analytical edge technology can provide new structural information and allow the identification of unknown polyphenols. In the present study the phenolic profiles of green and red oak-leaf lettuce cultivars were exhaustively characterized by ultrahigh performance liquid chromatography (UHPLC) coupled online to diode array detection (DAD), electrospray ionization (ESI) and quadrupole time-of-flight mass spectrometry (QToF/MS), using the MS(E) instrument acquisition mode for recording simultaneously exact masses of precursor and fragment ions...
August 22, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28822061/co-ultramicronized-palmitoylethanolamide-luteolin-facilitates-the-development-of-differentiating-and-undifferentiated-rat-oligodendrocyte-progenitor-cells
#15
Stephen D Skaper, Massimo Barbierato, Laura Facci, Mila Borri, Gabriella Contarini, Morena Zusso, Pietro Giusti
Oligodendrocytes, the myelin-producing cells of the central nervous system (CNS), have limited capability to bring about repair in chronic CNS neuroinflammatory demyelinating disorders such as multiple sclerosis (MS). MS lesions are characterized by a compromised pool of undifferentiated oligodendrocyte progenitor cells (OPCs) unable to mature into myelin-producing oligodendrocytes. An attractive strategy may be to replace lost OLs and/or promote their maturation. N-palmitoylethanolamine (PEA) is an endogenous fatty acid amide signaling molecule with anti-inflammatory and neuroprotective actions...
August 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28810652/expression-of-prostate-stem-cell-antigen-is-downregulated-during-flavonoid-induced-cytotoxicity-in-prostate-cancer-cells
#16
Qiang Zhang, Guangdong Cheng, Hongbin Qiu, Yuexin Wang, Jingtao Wang, Hui Xu, Tao Zhang, Lixin Liu, Ye Tao, Zhongjuan Ren
Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer cases and may be a potential therapeutic target in the treatment of prostate cancer. The present study evaluated the cytotoxicity of three flavonoids (genistein, luteolin and quercetin) towards DU145 prostate cancer cells, and investigated the effect of these flavonoids on PSCA expression. The results demonstrated that genistein, luteolin and quercetin inhibited the growth of DU145 cells in a dose-dependent manner (P<0.05) and induced morphological changes characteristic of apoptosis in DU145 cells...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808387/new-apigenin-glycoside-polyphenolic-constituents-anti-inflammatory-and-hepatoprotective-activities-of-gaillardia-grandiflora-and-gaillardia-pulchella-aerial-parts
#17
Fatma A Moharram, Rabab Abd El Moneim El Dib, Mohamed S Marzouk, Siham M El-Shenawy, Haitham A Ibrahim
BACKGROUND: Gaillardia grandiflora Hort. ex Van Houte and Gaillardia pulchella Foug are flowering plants widely cultivated in Egypt for their ornamental value. Previous reports demonstrated that sesquiterpene derivatives represent the major compounds in both species. Moreover, only few flavones were identified from genus Gaillardia and few studies on the cytotoxicity of G. pulchella were found. AIM OF THE STUDY: Investigation of the phenolic constituents of the aerial parts of both species and evaluation of their anti-inflammatory and hepatoprotective activities...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28805832/encapsulation-of-flavonoids-in-liposomal-delivery-systems-the-case-of-quercetin-kaempferol-and-luteolin
#18
Meigui Huang, Erzheng Su, Fuping Zheng, Chen Tan
The instability of dietary flavonoids is currently a challenge for their incorporation in functional foods. This study investigated the protective effects of liposome encapsulation on a variety of flavonoids and their interaction mechanisms. It was found that the incorporation of flavonoids into the liposomal membrane was strongly dependent on their structure and loading concentration. Liposomes loading quercetin and luteolin exhibited a relatively small size and homogeneous suspension compared to those loading kaempferol...
August 14, 2017: Food & Function
https://www.readbyqxmd.com/read/28801605/luteolin-a-natural-flavonoid-inhibits-methylglyoxal-induced-apoptosis-via-the-mtor-4e-bp1-signaling-pathway
#19
Yi Liu, Jie Huang, Xian Zheng, Xia Yang, Yan Ding, Tongyong Fang, Yuyun Zhang, Shuaishuai Wang, Xiaofei Zhang, Xuan Luo, Anlei Guo, Kelly A Newell, Yinghua Yu, Xu-Feng Huang
Methylglyoxal (MG) accumulation has been observed in human cerebrospinal fluid and body tissues under hyperglycaemic conditions. Recent research has demonstrated that MG-induces neuronal cell apoptosis, which promotes the development of diabetic encephalopathy. Our previous animal study has shown that luteolin, a natural flavonoid, attenuates diabetes-associated cognitive dysfunction. To further explore the neuroprotective properties of luteolin, we investigated the inhibitive effect of luteolin on MG-induced apoptosis in PC12 neuronal cells...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797651/biological-effects-and-chemical-characterization-of-iris-schachtii-markgr-extracts-a-new-source-of-bioactive-constituents
#20
Andrei Mocan, Gokhan Zengin, Adriano Mollica, Ahmet Uysal, Erdogan Gunes, Gianina Crișan, Abdurrahman Aktumsek
This study gathers information about the effects of different extracts (methanol and water) from rhizomes and aerial parts of Iris schachtii on selected enzymes (cholinesterases, alpha-amylase and alpha-glucosidase, tyrosinase and lipase) as well as on their antioxidant capacities and antimutagenic properties in relation with their phenolic composition. The chemical composition was assessed by determining total phenolic and flavonoid content as well as individual phenolic compounds by HPLC-DAD. Moreover, antioxidant abilities of the investigated extracts were tested by using different assays including free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating, overall rhizomes being indicated as a superior source of antioxidant compounds...
August 7, 2017: Food and Chemical Toxicology
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