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Bruch's membrane opening and OCT

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https://www.readbyqxmd.com/read/28922031/optic-nerve-head-characteristics-in-chronic-angle-closure-glaucoma-detected-by-swept-source-oct
#1
Dejiao Li, Taibo Li, Eleftherios I Paschalis, Haobing Wang, Elise V Taniguchi, Zi-Ning Choo, Marissa K Shoji, Scott H Greenstein, Stacey C Brauner, Angela V Turalba, Louis R Pasquale, Lucy Q Shen
PURPOSE: To compare structural features in prelaminar and laminar tissues of the optic nerve head (ONH) in chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG), and control subjects. MATERIALS AND METHODS: ONH imaging was performed using swept-source optical coherence tomography (SS-OCT) for measurements of minimum rim width at Bruch's membrane opening (BMO-MRW), horizontal, and vertical lamina cribrosa depth (LCD). Prelaminar defects, categorized as hole and wedge, and lamina cribrosa (LC) defects were identified...
September 18, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28862734/utility-of-bruch-membrane-opening-based-optic-nerve-head-parameters-in-myopic-subjects
#2
Marina Sastre-Ibañez, Jose M Martinez-de-la-Casa, Gema Rebolleda, Pilar Cifuentes-Canorea, Maria Nieves-Moreno, Laura Morales-Fernandez, Federico Saenz-Frances, Julian Garcia-Feijoo
PURPOSE: To evaluate whether the new rim analysis software with spectral-domain optical coherence tomography (SD-OCT) shows advantages over the retinal nerve fiber layer (RNFL) thickness in patients with moderate myopia. METHODS: In this prospective cross-sectional study, we studied 65 healthy subjects, 37 with spherical refractive errors in the range of -3 to -6 D (moderate, G1) and 28 with less than -3 D (low/non-myopic, G0). All patients were examined with Heidelberg Spectralis SD-OCT, including Glaucoma Premium Module Edition (GPME) software...
August 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28857943/visibility-of-optic-nerve-head-structures-with-spectral-domain-and-swept-source-optical-coherence-tomography
#3
Mónica M Loureiro, Jayme R Vianna, Vishva M Danthurebandara, Glen P Sharpe, Donna M Hutchison, Marcelo T Nicolela, Balwantray C Chauhan
PURPOSE: To compare the visibility of deep optic nerve head (ONH) structures and the visible area of the anterior surface of the lamina cribrosa (ASLC) with spectral-domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT). MATERIALS AND METHODS: In total, 33 glaucoma patients were imaged with SD-OCT (Spectralis, 24 radial B-scans centered on the ONH) and SS-OCT (Atlantis, 12 radial and a horizontal and vertical raster scan pattern containing 5 lines each, centered on the ONH)...
September 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28777226/is-the-optic-nerve-head-structure-impacted-by-a-diagnostic-lumbar-puncture-in-humans
#4
Muriel Poli, Philippe Denis, Eric Sellem, Ludwig-Serge Aho-Glélé, Alain M Bron
PURPOSE: The purpose of this study is to assess in vivo whether diagnostic lumbar puncture (LP) is followed by optic nerve head (ONH) and parapapillary anatomic changes in normal human eyes. MATERIALS AND METHODS: Prospective, single-center, observational case series. ONH structures (prelaminar tissue surface, anterior surface of the lamina cribrosa, central retinal vessels) and parapapillary structures (internal limiting membrane, posterior surfaces of retinal nerve fiber layer and Bruch membrane/retinal pigment epithelium complex, Bruch membrane opening, posterior surface of the choroid) were quantitatively evaluated by means of swept-source optical coherence tomography (Triton Ver...
August 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28774935/comparing-optical-coherence-tomography-radial-and-cube-scan-patterns-for-measuring-bruch-s-membrane-opening-minimum-rim-width-bmo-mrw-in-glaucoma-and-healthy-eyes-cross-sectional-and-longitudinal-analysis
#5
Sami W Kabbara, Linda M Zangwill, Rusdeep Mundae, Naama Hammel, Christopher Bowd, Felipe A Medeiros, Robert N Weinreb, Akram Belghith
AIM: To compare the cube and radial scan patterns of the spectral domain optical coherence tomography (SD-OCT) for quantifying the Bruch's membrane opening minimum rim width (BMO-MRW). METHODS: Sixty healthy eyes and 189 glaucomatous eyes were included. The optic nerve head cube and radial pattern scans were acquired using Spectralis SD-OCT. BMO-MRWs were automatically delineated using the San Diego Automated Layer Segmentation Algorithm. The BMO-MRW diagnostic accuracy for glaucoma detection and rates of change derived from the two scan patterns were compared...
August 3, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28732047/in-vivo-analysis-of-glaucoma-related-features-within-the-optic-nerve-head-using-enhanced-depth-imaging-optical-coherence-tomography
#6
Tiago S Prata, Flavio S Lopes, Vitor G Prado, Izabela Almeida, Igor Matsubara, Syril Dorairaj, Rafael L Furlanetto, Roberto M Vessani, Augusto Paranhos
Structural differences between optic nerve head (ONH) parameters in glaucomatous and non-glaucomatous eyes has been documented, however the association between such parameters in patients with different disease stages is yet to be elucidated. We investigated the relationship between different laminar and prelaminar ONH structures using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT) in a population with and without glaucoma. In this observational case-control study, we prospectively enrolled healthy individuals and glaucomatous patients with different disease stages...
2017: PloS One
https://www.readbyqxmd.com/read/28730092/parameters-of-ocular-fundus-on-spectral-domain-optical-coherence-tomography-for-glaucoma-diagnosis
#7
REVIEW
Yu-Lin Tao, Li-Ming Tao, Zheng-Xuan Jiang, He-Ting Liu, Kun Liang, Mo-Han Li, Xuan-Sheng Zhu, Yan-Lin Ren, Bing-Jie Cui
In this review, we summarize the progression of several parameters assessed by spectral-domain optical coherence tomography (SD-OCT) in recent years for the detection of glaucoma. Monitoring the progression of defects in the retinal nerve fiber layer (RNFL) thickness is essential. Imaging and analysis of retinal ganglion cells (RGCs) and inner plexiform layer (IPL), respectively, have been of great importance. Optic nerve head (ONH) topography obtained from 3D SD-OCT images is another crucial step. Other important assessments involve locating the Bruch's membrane opening (BMO), estimating the optic disc size and rim area, and measuring the lamina cribrosa displacement...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28650590/intra-and-interobserver-reproducibility-of-bruch-s-membrane-opening-minimum-rim-width-measurements-with-spectral-domain-optical-coherence-tomography
#8
Alexandre S C Reis, Camila E S Zangalli, Ricardo Y Abe, André L Silva, Jayme R Vianna, José Paulo C Vasconcellos, Vital P Costa
PURPOSE: To investigate the reproducibility of Bruch's membrane opening minimum rim width (BMO-MRW) and retinal nerve fibre layer thickness (RNFLT) measurements using spectral domain optical coherence tomography (SD-OCT). Additionally, to investigate the reproducibility of BMO area measurements and fovea to BMO centre (FoBMO) angle. METHODS: Participants were healthy subjects (n = 30) and patients with glaucoma (n = 26). One eye of each participant was scanned to obtain optic nerve head (24 radial B-scans) and peripapillary (one circular B-scan) images by three independent examiners...
June 26, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28615925/anterior-lamina-cribrosa-surface-depth-in-healthy-saudi-females
#9
Amira El-Agamy, Fayrouz Oteaf, Mohamed Berika
PURPOSE: This study was conducted to determine normative profile of anterior lamina cribrosa surface depth (ALCSD) in healthy Saudi females using Topcon Three-Dimensional (3D) Optical Coherence Tomography (OCT) 2000 - Spectral Domain (SD-OCT). In addition, the correlation between ALCSD and other clinical factors such as age, refractive error, intraocular pressure (IOP), central corneal thickness, anterior chamber depth, axial length, retinal nerve fiber layer thickness, and disk area was also assessed...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28564701/the-impact-of-lens-opacity-on-sd-oct-retinal-nerve-fiber-layer-and-bruch-s-membrane-opening-measurements-using-the-anatomical-positioning-system-aps
#10
Matthias M Mauschitz, Felix Roth, Frank G Holz, Monique M B Breteler, Robert P Finger
Purpose: To evaluate the impact of lens opacity on retinal nerve fiber layer thickness (RNFLT) and Bruch's membrane opening (BMO) measurements. Methods: Fifty-nine randomly selected patients without any other relevant ocular pathology undergoing elective routine cataract surgery in two specialized eye clinics were enrolled. RNFLT, BMO area, and BMO minimum rim width (BMO-MRW) were assessed with the Heidelberg Engineering Spectralis OCT using the anatomical positioning system (APS) prior to and 1 day after cataract surgery using a ring scan at different eccentricities of the disc (3...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28528295/a-machine-learning-graph-based-approach-for-3d-segmentation-of-bruch-s-membrane-opening-from-glaucomatous-sd-oct-volumes
#11
Mohammad Saleh Miri, Michael D Abràmoff, Young H Kwon, Milan Sonka, Mona K Garvin
Bruch's membrane opening-minimum rim width (BMO-MRW) is a recently proposed structural parameter which estimates the remaining nerve fiber bundles in the retina and is superior to other conventional structural parameters for diagnosing glaucoma. Measuring this structural parameter requires identification of BMO locations within spectral domain-optical coherence tomography (SD-OCT) volumes. While most automated approaches for segmentation of the BMO either segment the 2D projection of BMO points or identify BMO points in individual B-scans, in this work, we propose a machine-learning graph-based approach for true 3D segmentation of BMO from glaucomatous SD-OCT volumes...
July 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28490427/effect-of-acute-intraocular-pressure-elevation-on-the-minimum-rim-width-in-normal-ocular-hypertensive-and-glaucoma-eyes
#12
Sourabh Sharma, Tin A Tun, Mani Baskaran, Eray Atalay, Sri Gowtham Thakku, Zhang Liang, Dan Milea, Nicholas G Strouthidis, Tin Aung, Michael Ja Girard
BACKGROUND: To estimate and compare changes in the Bruch's membrane opening-minimum rim width (BMO-MRW) and area in normal, ocular hypertensive and glaucoma eyes following acute elevations in intraocular pressure (IOP). METHODS: The optic nerve heads (ONHs) of 104 subjects (31 normals, 20 ocular hypertension (OHT) and 53 with primary glaucoma) were imaged using Spectral-domain optical coherence tomography (OCT; Spectralis, Heidelberg Engineering, Germany). IOP was raised twice by applying a force (0...
May 10, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28481929/horizontal-and-vertical-optic-disc-rotation-the-beijing-eye-study
#13
Yuan Yuan Fan, Jost B Jonas, Ya Xing Wang, Chang Xi Chen, Wen Bin Wei
PURPOSE: To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters. DESIGN: Population-based study. METHODS: In the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 years; range:50-93 years) underwent an ophthalmological examination which included spectral-domain optical coherence tomography (OCT) with enhanced depth imaging. Using the OCT images, we determined the amount of the rotation of the optic disc (defined as Bruch´s membrane opening (BMO)) around the vertical axis and horizontal axis...
2017: PloS One
https://www.readbyqxmd.com/read/28394809/structure-function-relationship-between-the-bruch-membrane-opening-based-minimum-rim-width-and-visual-field-defects-in-advanced-glaucoma
#14
Serhat Imamoglu, Nimet Burcu Celik, Mehmet S Sevim, Gokhan Pekel, Nimet Yesim Ercalik, Esra Turkseven Kumral, Handan Bardak
PURPOSE: To investigate the relationship between the Bruch membrane opening-minimum rim width (BMO-MRW) (global and temporal) parameters with spectral-domain optical coherence tomography (SD-OCT) and visual field (VF) sensitivity on the 10-2 test in patients with advanced glaucoma. MATERIALS AND METHODS: This cross-sectional, observational study included a total of 33 eyes of 29 patients. To evaluate VF sensitivity, automated white-on-white perimetry was performed using a Humphrey field analyzer...
June 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28391369/relationship-between-lamina-cribrosa-displacement-and-trans-laminar-pressure-difference-in-papilledema
#15
Javier García-Montesinos, Francisco J Muñoz-Negrete, Victoria de Juan, Gema Rebolleda
PURPOSE: The purpose of this study was to describe morphological changes in lamina cribrosa (LC), prelaminar tissue thickness (PTT) and Bruch's membrane opening (BMO) in eyes affected by papilledema and correlate them with trans-LC-pressure difference (TLCD). METHODS: This was a prospective study, including twelve eyes newly diagnosed of papilledema. Eyes underwent scanning with Spectralis-OCT with enhanced depth imaging to compare BMO, anterior LC surface position (LC depth-LCD-) and PTT before and after oedema resolution...
June 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28387764/crowded-optic-nerve-head-evaluation-with-optical-coherence-tomography-in-anterior-ischemic-optic-neuropathy
#16
S Moghimi, M Afzali, M Akbari, K B Ebrahimi, A Khodabande, A R Yazdani-Abyaneh, S N H Ghafouri, P Coh, S Okhravi, M A Fard
PurposeTo characterize the optic nerve head (ONH) structure in patients with non-arteritic anterior ischemic optic neuropathy (NAION) compared to healthy control subjects using spectral domain optical coherence tomography (SD-OCT) via the enhanced depth imaging method.MethodsIn this prospective, cross-sectional, comparative study, we assessed 66 eyes of 33 patients with unilateral NAION and 31 eyes of 31 healthy normal subjects in an academic institution. The peripapillary nerve fiber layer thickness, disc area, and quantitative parameters of the ONH structures, including the Bruch's membrane opening (BMO) area, anterior laminar depth, and prelaminar thickness and depth were compared between the three groups...
August 2017: Eye
https://www.readbyqxmd.com/read/28315514/optic-nerve-head-in-central-retinal-vein-occlusion-by-spectral-domain-oct
#17
Antonio Longo, Teresio Avitabile, Maurizio G Uva, Vincenza Bonfiglio, Andrea Russo, Mario D Toro, Caterina Gagliano, Matteo Fallico, Michele Reibaldi
PURPOSE: To evaluate the morphology of optic nerve head by spectral-domain optical coherence tomography (SD-OCT) in patients with unilateral central retinal vein occlusion (CRVO). METHODS: In 39 consecutive patients with unilateral CRVO and 39 healthy controls, morphologic parameters of optic nerve head were assessed in both eyes by Spectralis SD-OCT using a custom radial B-scan pattern. The length of Bruch membrane opening (BMO) was measured in OCT scans, and optic disc diameters (DD) were assessed in infrared fundus photographs...
June 26, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28275526/quantifying-variability-in-longitudinal-peripapillary-rnfl-and-choroidal-layer-thickness-using-surface-based-registration-of-oct-images
#18
Sieun Lee, Morgan Heisler, Paul J Mackenzie, Marinko V Sarunic, Mirza Faisal Beg
PURPOSE: To assess within-subject variability of retinal nerve fiber layer (RNFL) and choroidal layer thickness in longitudinal repeat optical coherence tomography (OCT) images with point-to-point measurement comparison made using nonrigid surface registration. METHODS: Nine repeat peripapillary OCT images were acquired over 3 weeks from 12 eyes of 6 young, healthy subjects using a 1060-nm prototype swept-source device. The RNFL, choroid and the Bruch's membrane opening (BMO) were segmented, and point-wise layer thicknesses and BMO dimensions were measured...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27951592/novel-bruch-s-membrane-opening-minimum-rim-area-equalizes-disc-size-dependency-and-offers-high-diagnostic-power-for-glaucoma
#19
COMPARATIVE STUDY
Philip Enders, Werner Adler, Friederike Schaub, Manuel M Hermann, Thomas Dietlein, Claus Cursiefen, Ludwig M Heindl
Purpose: The purpose of this study was to assess the diagnostic power of the novel two-dimensional parameter Bruch's membrane opening minimal rim area (BMO-MRA) in spectral-domain optical coherence tomography (SD-OCT) for detection of glaucoma compared to minimal rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in large and small optic discs. Methods: In this case-control, cross-sectional study, 207 eyes of 207 participants, including 89 controls and 97 patients with glaucoma and 21 with ocular hypertension (OHT), with a disc size <1...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27814326/consistency-of-bruch-membrane-opening-detection-as-determined-by-optical-coherence-tomography
#20
Young Hoon Hwang, Min K Kim, Sang I Ahn
PURPOSE: To investigate the consistency of Bruch membrane opening (BMO) detection as determined by Cirrus high-definition optical coherence tomography (OCT). MATERIALS AND METHODS: This study enrolled 106 healthy eyes and 194 glaucomatous eyes who underwent OCT examinations. The location of BMO was evaluated by inspecting 72 cross-sectional optic nerve head (ONH) images (5 degrees intervals for 360 degrees) per eye in which BMO location is automatically detected by the OCT algorithm...
November 2016: Journal of Glaucoma
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