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Bruch's membrane opening and OCT

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https://www.readbyqxmd.com/read/27814326/consistency-of-bruch-membrane-opening-detection-as-determined-by-optical-coherence-tomography
#1
Young Hoon Hwang, Min K Kim, Sang I Ahn
PURPOSE: To investigate the consistency of Bruch membrane opening (BMO) detection as determined by Cirrus high-definition optical coherence tomography (OCT). MATERIALS AND METHODS: This study enrolled 106 healthy eyes and 194 glaucomatous eyes who underwent OCT examinations. The location of BMO was evaluated by inspecting 72 cross-sectional optic nerve head (ONH) images (5 degrees intervals for 360 degrees) per eye in which BMO location is automatically detected by the OCT algorithm...
November 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27796669/vertical-asymmetry-of-lamina-cribrosa-tilt-angles-using-wide-bandwidth-femtosecond-mode-locked-laser-oct-effect-of-myopia-and-glaucoma
#2
Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Makoto Araie, Shin Yoneya
PURPOSE: Morphological features of the lamina cribrosa (LC) and optic disc may be important in the pathogenesis of glaucoma and myopic neuropathy. We therefore performed a cross-sectional study of patients with glaucoma and myopic neuropathy to evaluate vertical asymmetry of LC tilt angles (LCTAs) from Bruch's membrane opening (BMO). MATERIAL AND METHODS: Forty-six control eyes and 35 primary open-angle glaucoma (POAG) eyes were included. A raster scanning protocol with 300 single B-scans (without averaging) were obtained using optical coherence tomography with a wide-bandwidth, femtosecond mode-locked (ML) laser...
October 28, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27764824/intra-and-inter-rater-agreement-of-anterior-lamina-cribrosa-depth-measurements-using-enhanced-depth-imaging-optical-coherence-tomography
#3
Inês Leal, David Cordeiro Sousa, Filomena Pinto, Carlos Marques-Neves, Luís Abegão Pinto
PURPOSE: To determine intra- and inter-rater agreement of anterior lamina cribrosa depth (ALCD) manual measurements using enhanced-depth imaging optical coherence tomography (EDI-OCT). METHODS: Observational study. EDI-OCT of the optic nerve head was performed in healthy subjects. ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa (LC), at the maximum depth point...
October 21, 2016: Ophthalmic Research
https://www.readbyqxmd.com/read/27646335/relationship-between-intraocular-pressure-and-anterior-lamina-cribrosa-depth-a-cross-sectional-observational-study-in-a-healthy-portuguese-population
#4
David Cordeiro Sousa, Inês Leal, Carlos Marques-Neves, Filomena Pinto, Luís Abegão Pinto
PURPOSE: To investigate the association between anterior lamina cribrosa depth (ALCD), determined with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), and intraocular pressure (IOP) in a healthy Portuguese population. METHODS: In this cross-sectional observational study conducted between January and July 2015, 2 optic nerve head (ONH)-centered EDI-OCT cross-scans were performed and ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa at the maximum depth point...
September 13, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27636592/bruch-s-membrane-opening-minimum-rim-width-assessment-with-spectral-domain-optical-coherence-tomography-performs-better-than-confocal-scanning-laser-ophthalmoscopy-in-discriminating-early-glaucoma-patients-from-control-subjects
#5
Anani P Toshev, Julia Lamparter, Norbert Pfeiffer, Esther M Hoffmann
PURPOSE: To compare the diagnostic performance and evaluate diagnostic agreement for early glaucoma detection between a confocal scanning laser ophthalmoscope (CSLO) and a spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Fifty-five eyes of 55 open-angle glaucoma patients and 42 eyes of 42 healthy control subjects were enrolled in this observational, cross-sectional study. All participants underwent comprehensive ophthalmic examination, visual field testing, and optic nerve head and retinal nerve fiber layer imaging by CSLO (HRT3) and SD-OCT (Spectralis OCT)...
September 15, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27571013/peripapillary-nerve-fiber-elevation-in-young-healthy-eyes
#6
Takehiro Yamashita, Taiji Sakamoto, Naoya Yoshihara, Hiroto Terasaki, Minoru Tanaka, Yuya Kii, Kumiko Nakao
PURPOSE: Eyes with a peripapillary nerve fiber elevation (pNFE) are those with a discrepancy between the optic disc margin in a color fundus photograph and the Bruch's membrane opening in an optical coherent tomographic (OCT) cross-sectional image. The purpose of this study was to determine the prevalence of pNFE in young healthy eyes, and to compare the axial length and optic disc tilt between pNFE and non-pNFE groups. METHODS: This was a prospective, observational, cross-sectional study of 117 right eyes...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27557112/oct-based-quantification-and-classification-of-optic-disc-structure-in-glaucoma-patients
#7
Naoko Takada, Kazuko Omodaka, Tsutomu Kikawa, Airi Takagi, Akiko Matsumoto, Yu Yokoyama, Yukihiro Shiga, Kazuichi Maruyama, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa
PURPOSE: To objectively classify the optic discs of open-angle glaucoma (OAG) patients into Nicolela's four disc types, i.e., focal ischemic (FI), myopic (MY), senile sclerotic (SS), and generalized enlargement (GE), with swept-source optical coherence tomography (SS-OCT). METHODS: This study enrolled 113 eyes of 113 OAG patients (mean age: 62.5 ± 12.6; Humphrey field analyzer-measured mean deviation: -9.4 ± 7.3 dB). Newly developed software was used to quantify a total of 20 optic disc parameters in SS-OCT (DRI OCT-1, TOPCON) images of the optic disc...
2016: PloS One
https://www.readbyqxmd.com/read/27548890/glaucoma-diagnostic-ability-of-the-new-circumpapillary-retinal-nerve-fiber-layer-thickness-analysis-based-on-bruch-s-membrane-opening
#8
Eun Ji Lee, Kyoung Min Lee, Hyunjoong Kim, Tae-Woo Kim
PURPOSE: To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic disc. METHODS: In 75 eyes with primary open-angle glaucoma (POAG) and 71 healthy control eyes, circumpapillary RNFL thickness was measured with SD-OCT, first by centering the scan circle on the optic disc (RNFLDi), and then on the BMO (RNFLBMO)...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27548889/intereye-difference-in-the-microstructure-of-parapapillary-atrophy-in-unilateral-primary-open-angle-glaucoma
#9
Yung Ju Yoo, Eun Ji Lee, Tae-Woo Kim
PURPOSE: To investigate intereye differences in the parapapillary atrophy (PPA) microstructure in unilateral primary open-angle glaucoma (POAG). METHODS: Bilateral optic nerves from 172 unilateral POAG patients having clinical PPA shown in infrared fundus imaging were scanned using spectral-domain optical coherence tomography (SD-OCT). Based on the extent of Bruch's membrane (BM) within the PPA area, the PPA was divided into β-zone (area with BM) and γ-zone (area devoid of BM)...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27521172/optic-nerve-head-development-in-healthy-infants-and-children-using-handheld-spectral-domain-optical-coherence-tomography
#10
Aarti Patel, Ravi Purohit, Helena Lee, Viral Sheth, Gail Maconachie, Eleni Papageorgiou, Rebecca J McLean, Irene Gottlob, Frank A Proudlock
PURPOSE: To determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective cross-sectional study. PARTICIPANTS: Three hundred fifty-two children aged between 1 day and 13 years. METHODS: All participants were imaged using handheld SD OCT without sedation during a single scan session...
October 2016: Ophthalmology
https://www.readbyqxmd.com/read/27507325/incorporation-of-gradient-vector-flow-field-in-a-multimodal-graph-theoretic-approach-for-segmenting-the-internal-limiting-membrane-from-glaucomatous-optic-nerve-head-centered-sd-oct-volumes
#11
Mohammad Saleh Miri, Victor A Robles, Michael D Abràmoff, Young H Kwon, Mona K Garvin
The internal limiting membrane (ILM) separates the retina and optic nerve head (ONH) from the vitreous. In the optical coherence tomography volumes of glaucoma patients, while current approaches for the segmentation of the ILM in the peripapillary and macular regions are considered robust, current approaches commonly produce ILM segmentation errors at the ONH due to the presence of blood vessels and/or characteristic glaucomatous deep cupping. Because a precise segmentation of the ILM surface at the ONH is required for computing several newer structural measurements including Bruch's membrane opening-minimum rim width (BMO-MRW) and cup volume, in this study, we propose a multimodal multiresolution graph-based method to precisely segment the ILM surface within ONH-centered spectral-domain optical coherence tomography (SD-OCT) volumes...
July 25, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/27479577/-bruch-s-membrane-opening-in-oct-in-correlation-with-corneal-correction-a-pilot-study
#12
J Luebke, D Böhringer, T Reinhard, A Anton
: Background: The measurement by optical coherence tomography (OCT) of the Bruch membrane opening (BMO) and the thinnest retinal fiber nerve layer in relation to it (BMO-MRW) has been performed in clinical routine since 2014. To compensate for astigmatism, or increased or decreased corneal power, a correction is performed through the mean K-value of the measured eye. The aim of this study was to measure the value of this correction and its influence on the measurement results. Methods: The sectors of BMO-MRW and BMO values of the five right eyes of five healthy patients were measured five times each with Heidelberg Spectralis OCT...
August 1, 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27436783/the-use-of-bruch-s-membrane-opening-based-optical-coherence-tomography-of-the-optic-nerve-head-for-glaucoma-detection-in-microdiscs
#13
Philip Enders, Friederike Schaub, Werner Adler, Roman Nikoluk, Manuel M Hermann, Ludwig M Heindl
PURPOSE: To assess the performance of Bruch's membrane opening (BMO)-based spectral domain optical coherence tomography (SD-OCT) of the optic nerve head for glaucoma detection in microdiscs in comparison with confocal scanning laser tomography (CSLT). DESIGN: Retrospective cohort study. METHODS: 82 eyes of 82 patients with disc size <1.63 mm(2) underwent SD-OCT and CSLT measurements, visual field testing and clinical examination. BMO-based minimal rim width (BMO-MRW), retinal nerve fibre layer thickness (RNFLT) in SD-OCT and rim area measured in CSLT were compared and correlated with visual field defects...
July 19, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27409498/in-vivo-detection-of-laminar-and-peripapillary-scleral-hypercompliance-in-early-monkey-experimental-glaucoma
#14
Kevin M Ivers, Hongli Yang, Stuart K Gardiner, Lirong Qin, Luke Reyes, Brad Fortune, Claude F Burgoyne
PURPOSE: To compare optical coherence tomography (OCT) detected, optic nerve head (ONH) compliance within control and experimental glaucoma (EG) eyes of 15 monkeys at EG onset. METHODS: Intraocular pressure (IOP) was chronically elevated in one eye of each animal using a laser. Experimental glaucoma onset was identified using confocal scanning laser tomography (CSLT). Optical coherence tomography ONH imaging (40 radial B-scans) was performed at 10 mm Hg before and after laser...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27320517/topographic-correlation-between-juxtapapillary-choroidal-thickness-and-microstructure-of-parapapillary-atrophy
#15
Seung Hyen Lee, Eun Ji Lee, Tae-Woo Kim
PURPOSE: To investigate the topographic relationship between the juxtapapillary choroidal thickness (JPCT) and the microstructure of parapapillary atrophy (PPA) in primary open-angle glaucoma (POAG). DESIGN: Cross-sectional observational study. PARTICIPANTS: A total of 126 eyes (76 POAG eyes and 50 healthy control eyes) of 126 subjects with β-zone PPA. METHODS: Optic nerve heads were imaged using spectral-domain optical coherence tomography (OCT) to measure the JPCT...
September 2016: Ophthalmology
https://www.readbyqxmd.com/read/27297219/comparison-of-swept-source-and-enhanced-depth-imaging-spectral-domain-optical-coherence-tomography-in-quantitative-characterisation-of-the-optic-nerve-head
#16
Dejiao Li, Elise V Taniguchi, Sophie Cai, Eleftherios I Paschalis, Haobing Wang, John B Miller, Angela V Turalba, Scott H Greenstein, Stacey Brauner, Louis R Pasquale, Lucy Q Shen
AIMS: To compare swept-source optical coherence tomography (SS-OCT) and enhanced depth imaging spectral-domain OCT (EDI-OCT) in quantitative assessment of optic nerve head (ONH) parameters. METHODS: In a cross-sectional study, patients with primary open angle glaucoma (POAG) and age-matched control subjects underwent SS-OCT and EDI-OCT B-scans of the ONH in a single visit. Two masked readers independently measured the horizontal and vertical lamina cribrosa depth (LCDH and LCDV, respectively), as well as thinnest Bruch's membrane opening minimum rim width (BMO-MRW) from SS-OCT and EDI-OCT scans...
June 13, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27198638/anterior-lamina-cribrosa-surface-position-in-idiopathic-intracranial-hypertension-and-glaucoma
#17
Jenni Martinez Villarruel, Xiao Q Li, Daniella Bach-Holm, Steffen Hamann
PURPOSE: To compare the anterior lamina cribrosa (LC) surface position in patients with idiopathic intracranial hypertension (IIH), primary open-angle glaucoma (high-tension glaucoma [HTG] and normal-tension glaucoma [NTG]), and healthy controls using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT). METHODS: This was a retrospective, cross-sectional observational study of 11 eyes with IIH, 20 eyes with HTG, 20 eyes with NTG, and 37 control eyes...
May 16, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27162227/bruch-s-membrane-opening-changes-and-lamina-cribrosa-displacement-in-non-arteritic-anterior-ischaemic-optic-neuropathy
#18
Gema Rebolleda, Javier García-Montesinos, Elisabet De Dompablo, Noelia Oblanca, Francisco J Muñoz-Negrete, Julio J González-López
PURPOSE: To describe the morphological changes in the lamina cribrosa (LC) and prelaminar tissue (PT) from eyes with non-arteritic anterior ischaemic optic neuropathy (NAION) using enhanced depth imaging (EDI) optical coherence tomography (OCT), and to evaluate whether these changes correlate with retinal nerve fibre layer (RNFL) thickness and visual acuity (VA). DESIGN/METHODS: A prospective case-control study was performed, including 17 study eyes with NAION and 17 control, uninvolved eyes from 17 patients...
May 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27118190/neuroretinal-rim-in-non-glaucomatous-large-optic-nerve-heads-a-comparison-of-confocal-scanning-laser-tomography-and-spectral-domain-optical-coherence-tomography
#19
Philip Enders, Friederike Schaub, Manuel M Hermann, Claus Cursiefen, Ludwig M Heindl
BACKGROUND/AIMS: To compare margin-based rim area measurements from confocal scanning laser tomography (CSLT) with Bruch's membrane opening (BMO)-based measurements from spectral domain optical coherence tomography (SD-OCT) by analysis of a group of non-glaucomatous eyes with large optic discs, so-called macrodiscs (disc size >2.45 mm(2) in CSLT). Objective is to create a reference base for large optic nerve heads in SD-OCT diagnostics. METHODS: 102 eyes received CSLT and SD-OCT measurements and clinical examination on the same day...
April 26, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27100404/clinical-factors-associated-with-lamina-cribrosa-thickness-in-patients-with-glaucoma-as-measured-with-swept-source-optical-coherence-tomography
#20
COMPARATIVE STUDY
Kazuko Omodaka, Seri Takahashi, Akiko Matsumoto, Shigeto Maekawa, Tsutomu Kikawa, Noriko Himori, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Akiba, Toru Nakazawa
PURPOSE: To investigate the influence of various risk factors on thinning of the lamina cribrosa (LC), as measured with swept-source optical coherence tomography (SS-OCT; Topcon). METHODS: This retrospective study comprised 150 eyes of 150 patients: 22 normal subjects, 28 preperimetric glaucoma (PPG) patients, and 100 open-angle glaucoma patients. Average LC thickness was determined in a 3 x 3 mm cube scan of the optic disc, over which a 4 x 4 grid of 16 points was superimposed (interpoint distance: 175 μm), centered on the circular Bruch's membrane opening...
2016: PloS One
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