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Tropical Pathology

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https://www.readbyqxmd.com/read/28919835/high-resolution-infrared-thermography-a-new-tool-to-assess-tungiasis-associated-inflammation-of-the-skin
#1
Angela Schuster, Marlene Thielecke, Vaomalala Raharimanga, Charles Emile Ramarokoto, Christophe Rogier, Ingela Krantz, Hermann Feldmeier
BACKGROUND: Tungiasis is highly prevalent in low- and middle-income countries but remains often under diagnosed and untreated eventually leading to chronic sequels. The objective of the study was to assess whether tungiasis-associated inflammation can be detected and quantified by high-resolution infrared thermography (HRIT) and whether after removal of the parasite inflammation resolves rapidly. METHODS: Patients with tungiasis were identified through active case finding...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28904127/therapeutic-effects-of-monoclonal-antibody-against-dengue-virus-ns1-in-a-stat1-knockout-mouse-model-of-dengue-infection
#2
Shu-Wen Wan, Pei-Wei Chen, Chin-Yu Chen, Yen-Chung Lai, Ya-Ting Chu, Chia-Yi Hung, Han Lee, Hsuan Franziska Wu, Yung-Chun Chuang, Jessica Lin, Chih-Peng Chang, Shuying Wang, Ching-Chuan Liu, Tzong-Shiann Ho, Chiou-Feng Lin, Chien-Kuo Lee, Betty A Wu-Hsieh, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin
Dengue virus (DENV) is the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome and is endemic to tropical and subtropical regions of the world. Our previous studies showed the existence of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1) which are cross-reactive with host Ags and trigger anti-DENV NS1 Ab-mediated endothelial cell damage and platelet dysfunction. To circumvent these potentially harmful events, we replaced the C-terminal region of DENV NS1 with the corresponding region from Japanese encephalitis virus NS1 to create chimeric DJ NS1 protein...
September 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28902908/histological-assessment-of-granulomas-in-natural-and-experimental-schistosoma-mansoni-infections-using-whole-slide-imaging
#3
Kátia B Amaral, Thiago P Silva, Felipe F Dias, Kássia K Malta, Florence M Rosa, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and socioeconomic importance, results from the parasite eggs that become trapped in host tissues, particularly in the liver and intestines. Continuous antigenic stimulation from these eggs leads to recruitment of inflammatory cells to the sites of infection with formation of periovular granulomas. These complex structures have variable size and composition and are the most striking histopathological feature of schistosomiasis mansoni...
2017: PloS One
https://www.readbyqxmd.com/read/28867257/oropharyngeal-candidiasis-prevalence-among-hiv-infected-patients-at-the-teaching-hospital-of-treichville-abidjan-c%C3%A3-te-d-ivoire
#4
A Konaté, P C M Barro-Kiki, K F Kassi, K E Angora, H Vanga-Bosson, V Djohan, A V Bédia-Tanoh, A J S Miézan, W Yavo, E I H Menan
AIM OF THE STUDY: The aim of this study was to determine the mycological profile of oropharyngeal candidiasis among HIV-infected patients from Internal Medicine, Infectious and Tropical Diseases, and Pneumo-Phthisiology Diseases departments of the Teaching Hospital of Treichville in Abidjan, Côte d'Ivoire. PATIENTS AND METHODS: This was a cross-sectional study carried out on patients with lesions suggestive of oropharyngeal candidiasis from October 2010 to April 2011...
August 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28859850/il-4-5-signalling-plays-an-important-role-during-litomosoides-sigmodontis-infection-influencing-both-immune-system-regulation-and-tissue-pathology-in-the-thoracic-cavity
#5
Manuel Ritter, Ruth S Tamadaho, Judith Feid, Wenzel Vogel, Katharina Wiszniewsky, Sven Perner, Achim Hoerauf, Laura E Layland
Approximately 100 million people suffer from filarial diseases including lymphatic filariasis (elephantiasis), onchocerciasis (river blindness) and loiasis. These diseases are amongst the most devastating of the neglected tropical diseases in terms of social and economic impact. Moreover, many infection-induced immune mechanisms in the host, their relationship to disease-related symptoms and the development of pathology within the site of infection remain unclear. To improve on current drug therapies or vaccines, further studies are necessary to decipher the mechanisms behind filaria-driven immune responses and pathology development, and thus the rodent model of Litomosoides sigmodontis can be used to unravel host-filaria interactions...
August 30, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28853599/pyomyositis-of-the-pectineus-muscle-in-an-adolescent-male
#6
J Hiddema, S Hassan, N Mangat, N Siddiqui
The 'irritable hip' continues to pose a challenge for clinicians. Even with predictive clinical algorithms, decision making can be difficult. Emergency treatment is required if septic arthritis is suspected. Other differential diagnoses such as transient synovitis, pyomyositis of the pelvic girdle muscles and osteomyelitis must be considered in order to help guide appropriate investigations and allow early treatment. We report the case of a 13-year-old boy presenting to our institution with an acutely painful left hip but still able to weight bear...
September 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28842267/medicinal-properties-of-mangosteen-garcinia-mangostana-l-a-comprehensive-update
#7
REVIEW
Berenice Ovalle-Magallanes, Dianelena Eugenio-Pérez, José Pedraza-Chaverri
Garcinia mangostana L. (Clusiaceae) is a tropical tree native to Southeast Asia known as mangosteen which fruits possess a distinctive and pleasant taste that has granted them the epithet of "queen of the fruits". The seeds and pericarps of the fruit have a long history of use in the traditional medicinal practices of the region, and beverages containing mangosteen pulp and pericarps are sold worldwide as nutritional supplements. The main phytochemicals present in the species are isoprenylated xanthones, a class of secondary metabolites with multiple reports of biological effects, such as antioxidant, pro-apoptotic, anti-proliferative, antinociceptive, anti-inflammatory, neuroprotective, hypoglycemic and anti-obesity...
August 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28808960/the-application-of-humanized-mouse-models-for-the-study-of-human-exclusive-viruses
#8
Fatemeh Vahedi, Elizabeth C Giles, Ali A Ashkar
The symbiosis between humans and viruses has allowed human tropic pathogens to evolve intricate means of modulating the human immune response to ensure its survival among the human population. In doing so, these viruses have developed profound mechanisms that mesh closely with our human biology. The establishment of this intimate relationship has created a species-specific barrier to infection, restricting the virus-associated pathologies to humans. This specificity diminishes the utility of traditional animal models...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28799498/structure-based-approaches-targeting-parasite-cysteine-proteases
#9
Rafael Pinto Vieira, Viviane Corrêa Santos, Rafaela Salgado Ferreira
Cysteine proteases are essential hydrolytic enzymes present in the majority of organisms, including viruses and unicellular parasites. Despite the high sequence identity displayed among these proteins, specific structural features across different species grant distinct functions to these biomolecules, frequently related to pathological conditions. Consequently, their relevance as promising targets for potential specific inhibitors has been highlighted and occasionally validated in recent decades. In this review, we discuss the recent outcomes on structure-based campaigns aiming the discovery of new inhibitor prototypes against cruzain and falcipain, as alternative therapeutic tools for Chagas disease and malaria treatments, respectively...
August 10, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28798144/frontline-science-leishmania-mexicana-amastigotes-can-replicate-within-neutrophils
#10
Benjamin P Hurrell, Manon Beaumann, Sandrina Heyde, Ivo B Regli, Andreas J Müller, Fabienne Tacchini-Cottier
Cutaneous leishmaniasis is a neglected tropical disease, causing a spectrum of clinical manifestations varying from self-healing to unhealing lesions that may be very difficult to treat. Emerging evidence points to a detrimental role for neutrophils during the first hours following infection with many distinct Leishmania species (spp.) at a time when the parasite is in its nonreplicative promastigote form. Neutrophils have also been detected at later stages of infection in unhealing chronic cutaneous lesions...
August 10, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28793309/the-microbiome-in-urogenital-schistosomiasis-and-induced-bladder-pathologies
#11
Adewale S Adebayo, Mangesh Survayanshi, Shrikanth Bhute, Atinuke M Agunloye, Raphael D Isokpehi, Chiaka I Anumudu, Yogesh S Shouche
BACKGROUND: Human schistosomiasis is a highly prevalent neglected tropical disease (NTD) caused by Schistosoma species. Research on the molecular mechanisms influencing the outcomes of bladder infection by Schistosoma haematobium is urgently needed to develop new diagnostics, therapeutics and infection prevention strategies. The objective of the research study was to determine the microbiome features and changes in urine during urogenital schistosomiasis and induced bladder pathologies...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28764177/idiopathic-tumoral-calcinosis-rare-clinico-pathological-entity-a-report-of-two-cases
#12
Sreedevi Jakka, Radhika Narayan, Minakshi Mishra, Farah Rana, J K Laik
Tumoral calcinosis is a rare disease reported mainly in blacks of tropical and subtropical African regions. It is characterized by tumour-like periarticular deposits of calcium that are found in the regions of the hip, shoulder, elbow and small joints of hands and feet. The involvement of this disease in a healthy patient is extremely rare in young and middle aged individuals. We are presenting two cases with large, painless periarticular swellings in subscapular joint and feet. First case presented with recurrent swelling in different anatomical locations at different time intervals involving the hip and followed by shoulder joint...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28759766/metal-toxicity-assessment-by-sentinel-species-of-mangroves-in-situ-case-study-integrating-chemical-and-biomarkers-analyses
#13
Luis Felipe de Almeida Duarte, Caroline Araújo de Souza, Camilo Dias Seabra Pereira, Marcelo Antonio Amaro Pinheiro
Globally, there is a lack of knowledge about tropical ecotoxicology dealing with the potential impact of metal contamination in mangrove ecosystem. This habitat is considered a nursery for several animal species, among them the "uçá"-crab (Ucides cordatus), known as a key species due to its biological and economical importance. This study evaluated the association involving metal contamination (Cd, Cu, Pb, Cr, Mn and Hg) in water, sediment, red-mangrove vegetation (Rhizophora mangle) and tissues of uçá crab, together with its geno-cytotoxic responses, based on micronucleated hemocytes frequency and the retention time of neutral red in lysosomes...
July 28, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28758666/maldi-ms-imaging-investigation-of-the-host-response-to-visceral-leishmaniasis
#14
C F Jaegger, F Negrão, D M Assis, K R A Belaz, C F F Angolini, A M A P Fernandes, V G Santos, A Pimentel, D R Abánades, S Giorgio, M N Eberlin, D F O Rocha
Mass spectrometry imaging (MSI) of animal tissues has become an important tool for in situ molecular analyses and biomarker studies in several clinical areas, but there are few applications in parasitological studies. Leishmaniasis is a neglected tropical disease, and experimental mouse models have been essential to evaluate pathological and immunological processes and to develop diagnostic methods. Herein we have employed MALDI MSI to examine peptides and low molecular weight proteins (2 to 20 kDa) differentially expressed in the liver during visceral leishmaniasis in mice models...
July 31, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28741648/american-cutaneous-leishmaniasis-in-infancy-and-childhood
#15
REVIEW
Alberto E Paniz-Mondolfi, Carolina Talhari, María F García Bustos, Tamara Rosales, Wilmer E Villamil-Gomez, Marilianna Marquez, Alexandra M Pérez Alvarez, Alejandra I Tálamo Sánchez, Alfonso J Rodriguez-Morales
Infant and young child skin diseases are among the most common features of morbidity throughout the tropics. Because the skin is directly exposed to the environment, it is considerably affected by climatic and local conditions such as vectors and microorganisms, as in the case of leishmaniasis. In America the observed magnitude of cutaneous leishmaniasis in children has led to the study of increased risk of exposure of this group due to the possibility of peri- and intradomiciliary transmission. The present review pretends to make a concrete approach all through the broad and main figures of this parasitic disease, including the clinical, physiopathological, epidemiological, diagnostic, and therapeutic aspects, in order to be used as a practical source of reference for pediatricians leading with tropical cutaneous pathology in the region...
July 25, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28736941/in-vivo-neutralization-of-%C3%AE-4-and-%C3%AE-7-integrins-inhibits-eosinophil-trafficking-and-prevents-lung-injury-during-tropical-pulmonary-eosinophilia-in-mice
#16
Pankaj Sharma, Aditi Sharma, Mrigank Srivastava
Integrins regulate leukocyte trafficking during homeostasis and inflammatory conditions. However, the role of α4 and β7 integrins in guiding eosinophil transmigration into the lungs during filarial manifestation of Tropical Pulmonary Eosinophilia (TPE) has not been explored. In this study, mice exhibiting TPE manifestations were administered with in vivo neutralizing antibodies against integrins α4 and β7 or their combination and immuno-pathological parameters were evaluated. Results show an intact lung barrier, significantly lower lung inflammation and reduced eosinophil counts in the Bronchoalveolar lavage fluid and lungs of mice receiving anti-α4(+) β7 treatment...
July 24, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28663244/frontline-science-c-myc-regulates-p-selectin-glycoprotein-ligand-1-expression-in-monocytes-during-hiv-1-infection
#17
Ryan Connor, Letitia D Jones, Xing Qiu, Juilee Thakar, Sanjay B Maggirwar
Leukocyte extravasation is a crucial feature of the normal immune response to disease and infection and is implicated in various pathologies during chronic inflammatory disease. P-Selectin glycoprotein ligand-1 (PSGL-1) is critical for leukocyte extravasation; however, despite extensive study, it remains unclear how its expression is regulated, which in turn, impedes a more precise understanding of how its expression level affects transmigration. To investigate the regulation of PSGL-1, 60 subjects, with or without HIV infection, were recruited and PSGL-1 expression in monocytes was measured...
June 29, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28661890/reflective-practice-and-social-responsibility-in-family-medicine-effect-of-performing-an-international-rotation-in-a-developing-country
#18
Christine Loignon, Thomas Gottin, Carol Valois, François Couturier, Robert Williams, Pierre-Michel Roy
OBJECTIVE: To explore the perceived effect of an elective international health rotation on family medicine resident learning. DESIGN: Qualitative, collaborative study based on semistructured interviews. SETTING: Quebec. PARTICIPANTS: A sample of 12 family medicine residents and 9 rotation supervisors (N = 21). METHODS: Semistructured interviews of residents and rotation supervisors. MAIN FINDINGS: Residents and supervisors alike reported that their technical skills and relationship skills had benefited...
November 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28659489/transcriptional-profiling-confirms-the-therapeutic-effects-of-mast-cell-stabilization-in-a-dengue-disease-model
#19
Juliet Morrison, Abhay P S Rathore, Chinmay K Mantri, Siti A B Aman, Andrew Nishida, Ashley L St John
There are no approved therapeutics for the treatment of dengue disease despite the global prevalence of dengue virus (DENV) and its mosquito vectors. DENV infections can lead to vascular complications, hemorrhage, and shock due to the ability of DENV to infect a variety of immune and nonimmune cell populations. Increasingly, studies have implicated the host response as a major contributor to severe disease. Inflammatory products of various cell types, including responding T cells, mast cells (MCs), and infected monocytes, can contribute to immune pathology...
September 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28655585/igm-and-igg-responses-in-schistosoma-mansoni-infected-mice-using-egg-and-worm-antigens-does-response-vary-with-parasitic-burden-and-phase-of-infection
#20
Miguel Cosenza, Emilia Barrios, Pimali Felibertt, Angel Castillo-Corujo, Génesis Ochoa, Eva Velasquez, Alejandra Rojas
Schistosomiasis is a chronic parasitic disease caused by trematodes of the genus Schistosoma, endemic in tropical and subtropical regions. The hepatic pathology of this parasitic disease could develop complications, such as fibrosis and cirrhosis, which can be fatal. The Venezuelan endemic area is considered as one of low transmission, which complicates the detection of infected individuals and signals the importance of improving the sensitivity of immunodiagnostic methods. Using ELISA, an evaluation was conducted of IgM and IgG responses to soluble antigens of eggs and female worms (SEA and SFWA) and excretion-secretion products of eggs and female worms (ESPE and ESPAW) in infected Balb/c mice with different parasitic burden and infection times...
August 2017: Experimental Parasitology
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