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Tropical Pathology

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https://www.readbyqxmd.com/read/29127993/molecular-prevalence-risk-factors-assessment-and-haemato-biochemical-alterations-in-hepatozoonosis-in-dogs-from-punjab-india
#1
Kaushlendra Singh, Harkirat Singh, Nirbhay Kumar Singh, Neeraj Kashyap, Naresh Kumar Sood, Shitanshu Shekar Rath
Hepatozoonosis caused by Hepatozoon canis is an important tick-borne disease of dogs in tropical and sub-tropical regions throughout the world. In the present study evaluation of blood samples collected from 225 dogs presented at Small Animal Clinics, GADVASU, Ludhiana, Punjab (India) was done for the presence of H. canis by PCR based assay targeting a portion of 18S rRNA gene. Of the total samples subjected to PCR, an amplicon of 666bp was detected in 13.78% samples whereas, routine blood smear examination revealed gamonts in 5...
December 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/29124010/positive-fecal-occult-blood-test-as-a-diagnostic-cue-for-schistosoma-mansoni-infection-in-a-developed-country
#2
Itaru Nakamura, Kenji Yagi, Takashi Kumagai, Nobuo Ohta
The rise in eco-tourism and travel off the beaten track have increased numbers of tourists with schistosomiasis which is seldom seen in developed countries, although this disease is considered a neglected tropical disease especially in poor communities. A Guinean male living in Japan was seen complaining of severe constipation. He was positive for fecal occult blood (FOB) and underwent colonoscopy. Colonoscopy showed petechiae of the rectal mucosa, with pathologic examination of biopsy tissue showing calcified eggs of the genus Schistosoma...
2017: IDCases
https://www.readbyqxmd.com/read/29117212/quantitative-label-free-proteomic-analysis-of-human-urine-to-identify-novel-candidate-protein-biomarkers-for-schistosomiasis
#3
Olugbenga Samson Onile, Bridget Calder, Nelson C Soares, Chiaka I Anumudu, Jonathan M Blackburn
BACKGROUND: Schistosomiasis is a chronic neglected tropical disease that is characterized by continued inflammatory challenges to the exposed population and it has been established as a possible risk factor in the aetiology of bladder cancer. Improved diagnosis of schistosomiasis and its associated pathology is possible through mass spectrometry to identify biomarkers among the infected population, which will influence early detection of the disease and its subtle morbidity. METHODOLOGY: A high-throughput proteomic approach was used to analyse human urine samples for 49 volunteers from Eggua, a schistosomiasis endemic community in South-West, Nigeria...
November 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29104539/annonaceae-breaking-the-wall-of-inflammation
#4
REVIEW
Ali Attiq, Juriyati Jalil, Khairana Husain
Inventories of tropical forests have listed Annonaceae as one of the most diverse plant families. For centuries, it is employed in traditional medicines to cure various pathological conditions including snakebite, analgesic, astringent, diarrhea, dysentery, arthritis pain, rheumatism, neuralgia, and weight loss etc. Phytochemical analysis of Annonaceae family have reported the occurrence of alkaloids, flavonoids, triterpenes, diterpenes and diterpene flavone glycosides, sterols, lignans, and annonaceous acetogenin characteristically affiliated with Annonaceae sp...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29095820/-omic-investigations-of-protozoa-and-worms-for-a-deeper-understanding-of-the-human-gut-parasitome
#5
REVIEW
Valeria Marzano, Livia Mancinelli, Giorgia Bracaglia, Federica Del Chierico, Pamela Vernocchi, Francesco Di Girolamo, Stefano Garrone, Hyppolite Tchidjou Kuekou, Patrizia D'Argenio, Bruno Dallapiccola, Andrea Urbani, Lorenza Putignani
The human gut has been continuously exposed to a broad spectrum of intestinal organisms, including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years of coevolution, and plays a central role in human health. The modern lifestyles of Western countries, such as the adoption of highly hygienic habits, the extensive use of antimicrobial drugs, and increasing globalisation, have dramatically altered the composition of the gut milieu, especially in terms of its eukaryotic "citizens...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29049977/syk-gtp-rac-1-mediated-immune-stimulatory-effect-of-cuscuta-epithymum-ipomoea-batata-and-euphorbia-hirta-plant-extracts
#6
Vanitha Sagar Sudam, Ajay Godwin Potnuri, N J Prameela Subhashini
Polymorphonuclear neutrophils (PMNn) are the pivotal mediators of phagocytosis. In addition to neutropenia, impaired neutrophilic function is associated with pathological conditions and immuno-deficiencies. Henceforth, Immuno-stimulatory strategies targeting neutrophilic function are indeed powerful tools in combating obstinate infections. In appreciation towards the usefulness of herbal medicines in therapeutic scenario, the present study was carried out to analyse the immuno-stimulatory effect of Cuscuta epithymum, Ipomoea batata and Euphorbia hirta using in-vitro and in-vivo rodent experimental models...
October 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29018005/the-clinical-presentation-of-subcutaneous-phaeohyphomycosis-a-case-series-from-yetebon-ethiopia
#7
Rachel B Kang, Devin C Simonson, Sarah E Stoner, William A Agger
Subcutaneous phaeohyphomycosis is a chronic fungal infection usually found on the lower extremity and feet of agricultural workers in the tropics. It can present with various skin manifestations, verrucous to nodular plaques, and is caused by multiple species of fungi. Laboratory confirmation requires skin samples for pathology and fungal cultures. Cure, often difficult in resource-poor countries, requires months of antifungal therapy. We describe the cases of 3 men from Ethiopia who were seen and are being treated by American doctors who traveled there on a medical mission...
October 10, 2017: Clinical Medicine & Research
https://www.readbyqxmd.com/read/28994540/-protective-effect-of-shuyu-yiban-decoction-on-atherosclerosis-in-rats-induced-by-chronic-unpredictable-mild-stress
#8
Xiao-Jun Zheng, Zhi-Qiang Hu, Shu-Wei Luan, Ran Li, Yun Li, Jian-Liang Li, Yu-Jie Li, Xiao-Xin Zhu
Shuyu Yiban decoction(SYYB) has significant effect in treating the patients with coronary heart disease combined with chronic psychological stress. In this study, in order to observe the effects of SYYB on early formation of atherosclerosis(As) and inflammation response induced by chronic psychological stress, high-fat diet+intraperitoneal injections of Vitamin D3 were given to establish As early lesion models, and based on these models, chronic unpredictable mild stress(CUMS) was used to observe whether the chronic psychological stress could increase coronary atherosclerotic lesions investigate the intervention effect of SYYB(6...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28991665/spinal-cord-anteroposterior-atrophy-in-ham-tsp-magnetic-resonance-imaging-and-neuropathological-analyses
#9
Akitoshi Taniguchi, Hitoshi Mochizuki, Atsushi Yamashita, Kazutaka Shiomi, Yujiro Asada, Masamitsu Nakazato
To evaluate the spinal cord atrophy that occurs in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we conducted magnetic resonance imaging (MRI) and pathological analyses. In the MRI study, 15 patients with HAM/TSP and 20 age-matched normal control subjects were enrolled. Anteroposterior and transverse distances and cross-sectional areas were measured and calculated at the C2, C4, C6, T2, and T6 vertebral levels. In the pathological study, spinal cord autopsy specimens were compared between a HAM/TSP case and an adult T cell leukemia/lymphoma case...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28988681/pathophysiology-of-leishmania-infection-during-pregnancy
#10
REVIEW
Brandon A Berger, Allison H Bartlett, Nancy Gore Saravia, Norma Galindo Sevilla
The pathological processes resulting from parasitic infection are known to have important impacts on the mother child dyad during pregnancy. The roles of parasite transmission and the maternal immune response have been described in diseases such as malaria, toxoplasmosis, and trypanosomiasis. However, the impact of parasites of the genus Leishmania, etiological agents of the neglected tropical diseases tegumentary leishmaniasis (TL) and visceral leishmaniasis (VL), is comparatively less well known, though it is an increasingly recognized concern for infected mothers and their fetuses...
October 4, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28969414/vitamin-d-deficiency-in-refugees-in-italy
#11
L G De Filippis, I Trombetta, T Novella, M Alampi
The objective of the research is to determine 25[OH]D serum levels in refugees in Italy. In the following research we have taken into consideration the results of the monitoring of Vitamin D levels in 46 refugees of the Italian Service for protection of refugees and asylum seekers (SPRAR) system. The indicator of overall vitamin D status used was the circulating serum level of 25(OH)D. Data was analyzed using Microsoft Excel. In the refugees tested, the mean level of 25(OH)D resulted 9.18 ng/mL. The standard deviation was 4...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28947413/acute-appendicitis-due-to-schistosomiasis-four-cases-at-the-yalgado-ou%C3%A3-draogo-university-hospital-of-ouagadougou
#12
M Bazongo, A S Ouédraogo, M Zida, G P Bonkoungou, E Ouangré, A Sanou, N R Doamba, N Zongo, Y E Sawadogo, S S Traore
Acute appendicitis is a frequent pathology with diverse causes. Although Burkina Faso is a tropical country with endemic schistosomiasis, bilharzial appendicitis remains rare. We report 4 cases of appendicitis due to schistosomiasis that we treated at the university hospital of Yalgado Ouédraogo to call attention to the need for routine review of appendectomy parts. Four male patients, aged 22, 26, 30, and 35 years old, were admitted for abdominal pains. Eosinophilia was observed in one case. The preoperative diagnosis was acute appendicitis in 2 cases and appendiceal peritonitis in 2 others...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28919835/high-resolution-infrared-thermography-a-new-tool-to-assess-tungiasis-associated-inflammation-of-the-skin
#13
Angela Schuster, Marlene Thielecke, Vaomalala Raharimanga, Charles Emile Ramarokoto, Christophe Rogier, Ingela Krantz, Hermann Feldmeier
BACKGROUND: Tungiasis is highly prevalent in low- and middle-income countries but remains often under diagnosed and untreated eventually leading to chronic sequels. The objective of the study was to assess whether tungiasis-associated inflammation can be detected and quantified by high-resolution infrared thermography (HRIT) and whether after removal of the parasite inflammation resolves rapidly. METHODS: Patients with tungiasis were identified through active case finding...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28904127/therapeutic-effects-of-monoclonal-antibody-against-dengue-virus-ns1-in-a-stat1-knockout-mouse-model-of-dengue-infection
#14
Shu-Wen Wan, Pei-Wei Chen, Chin-Yu Chen, Yen-Chung Lai, Ya-Ting Chu, Chia-Yi Hung, Han Lee, Hsuan Franziska Wu, Yung-Chun Chuang, Jessica Lin, Chih-Peng Chang, Shuying Wang, Ching-Chuan Liu, Tzong-Shiann Ho, Chiou-Feng Lin, Chien-Kuo Lee, Betty A Wu-Hsieh, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin
Dengue virus (DENV) is the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome and is endemic to tropical and subtropical regions of the world. Our previous studies showed the existence of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1) which are cross-reactive with host Ags and trigger anti-DENV NS1 Ab-mediated endothelial cell damage and platelet dysfunction. To circumvent these potentially harmful events, we replaced the C-terminal region of DENV NS1 with the corresponding region from Japanese encephalitis virus NS1 to create chimeric DJ NS1 protein...
October 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28902908/histological-assessment-of-granulomas-in-natural-and-experimental-schistosoma-mansoni-infections-using-whole-slide-imaging
#15
Kátia B Amaral, Thiago P Silva, Felipe F Dias, Kássia K Malta, Florence M Rosa, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and socioeconomic importance, results from the parasite eggs that become trapped in host tissues, particularly in the liver and intestines. Continuous antigenic stimulation from these eggs leads to recruitment of inflammatory cells to the sites of infection with formation of periovular granulomas. These complex structures have variable size and composition and are the most striking histopathological feature of schistosomiasis mansoni...
2017: PloS One
https://www.readbyqxmd.com/read/28867257/oropharyngeal-candidiasis-prevalence-among-hiv-infected-patients-at-the-teaching-hospital-of-treichville-abidjan-c%C3%A3-te-d-ivoire
#16
A Konaté, P C M Barro-Kiki, K F Kassi, K E Angora, H Vanga-Bosson, V Djohan, A V Bédia-Tanoh, A J S Miézan, W Yavo, E I H Menan
AIM OF THE STUDY: The aim of this study was to determine the mycological profile of oropharyngeal candidiasis among HIV-infected patients from Internal Medicine, Infectious and Tropical Diseases, and Pneumo-Phthisiology Diseases departments of the Teaching Hospital of Treichville in Abidjan, Côte d'Ivoire. PATIENTS AND METHODS: This was a cross-sectional study carried out on patients with lesions suggestive of oropharyngeal candidiasis from October 2010 to April 2011...
August 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28859850/il-4-5-signalling-plays-an-important-role-during-litomosoides-sigmodontis-infection-influencing-both-immune-system-regulation-and-tissue-pathology-in-the-thoracic-cavity
#17
Manuel Ritter, Ruth S Tamadaho, Judith Feid, Wenzel Vogel, Katharina Wiszniewsky, Sven Perner, Achim Hoerauf, Laura E Layland
Approximately 100 million people suffer from filarial diseases including lymphatic filariasis (elephantiasis), onchocerciasis (river blindness) and loiasis. These diseases are amongst the most devastating of the neglected tropical diseases in terms of social and economic impact. Moreover, many infection-induced immune mechanisms in the host, their relationship to disease-related symptoms and the development of pathology within the site of infection remain unclear. To improve on current drug therapies or vaccines, further studies are necessary to decipher the mechanisms behind filaria-driven immune responses and pathology development, and thus the rodent model of Litomosoides sigmodontis can be used to unravel host-filaria interactions...
August 30, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28853599/pyomyositis-of-the-pectineus-muscle-in-an-adolescent-male
#18
J Hiddema, S Hassan, N Mangat, N Siddiqui
The 'irritable hip' continues to pose a challenge for clinicians. Even with predictive clinical algorithms, decision making can be difficult. Emergency treatment is required if septic arthritis is suspected. Other differential diagnoses such as transient synovitis, pyomyositis of the pelvic girdle muscles and osteomyelitis must be considered in order to help guide appropriate investigations and allow early treatment. We report the case of a 13-year-old boy presenting to our institution with an acutely painful left hip but still able to weight bear...
September 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28842267/medicinal-properties-of-mangosteen-garcinia-mangostana-l-a-comprehensive-update
#19
REVIEW
Berenice Ovalle-Magallanes, Dianelena Eugenio-Pérez, José Pedraza-Chaverri
Garcinia mangostana L. (Clusiaceae) is a tropical tree native to Southeast Asia known as mangosteen which fruits possess a distinctive and pleasant taste that has granted them the epithet of "queen of the fruits". The seeds and pericarps of the fruit have a long history of use in the traditional medicinal practices of the region, and beverages containing mangosteen pulp and pericarps are sold worldwide as nutritional supplements. The main phytochemicals present in the species are isoprenylated xanthones, a class of secondary metabolites with multiple reports of biological effects, such as antioxidant, pro-apoptotic, anti-proliferative, antinociceptive, anti-inflammatory, neuroprotective, hypoglycemic and anti-obesity...
August 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28808960/the-application-of-humanized-mouse-models-for-the-study-of-human-exclusive-viruses
#20
Fatemeh Vahedi, Elizabeth C Giles, Ali A Ashkar
The symbiosis between humans and viruses has allowed human tropic pathogens to evolve intricate means of modulating the human immune response to ensure its survival among the human population. In doing so, these viruses have developed profound mechanisms that mesh closely with our human biology. The establishment of this intimate relationship has created a species-specific barrier to infection, restricting the virus-associated pathologies to humans. This specificity diminishes the utility of traditional animal models...
2017: Methods in Molecular Biology
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