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https://www.readbyqxmd.com/read/28774308/polarity-directed-optimization-of-phytochemical-and-in-vitro-biological-potential-of-an-indigenous-folklore-quercus-dilatata-lindl-ex-royle
#1
Madiha Ahmed, Humaira Fatima, Muhammad Qasim, Bilquees Gul, Ihsan-Ul-Haq
BACKGROUND: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, cytotoxic, protein kinase inhibitory, antileishmanial and glucose modulatory attributes of a Himalayan medicinal plant- Quercus dilatata. METHODS: Total phenolic and flavonoid contents were determined colorimetrically and various polyphenols were identified by RP-HPLC analysis...
August 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28770462/predictive-value-of-18-f-fdg-pet-ct-in-patients-with-acute-type-b-aortic-intramural-hematoma
#2
Fan Yang, Jianfang Luo, Qingyi Hou, Nianjin Xie, Zhiqiang Nie, Wenhui Huang, Yuan Liu, Yingling Zhou, Jiyan Chen, Qingshan Geng
BACKGROUND: The clinical course and predictors of adverse aortic events (AAE) in patients with acute Stanford type B intramural hematoma (IMH) remain controversial. This study aimed to investigate whether (18)F-FDG PET/CT can predict risk in patients with acute type B IMH. METHODS AND RESULTS: This study included 34 patients with acute type B IMH who underwent PET/CT within 14 days from the onset of symptoms. The maximal standardized uptake values (SUVmax) of (18)F-FDG uptake was significantly different between patients with or without AAE (4...
August 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28769001/selected-physicochemical-and-biological-properties-of-ethyl-ascorbic-acid-compared-to-ascorbic-acid
#3
Iwona Golonka, Monika Oleksy, Adam Junka, Agnieszka Matera-Witkiewicz, Marzenna Bartoszewicz, Witold Musiał
The aim of the work was the evaluation of selected biological and physicochemical, applicative properties of ethylated ascorbic acid (AAE) compared to ascorbic acid (AA). Thermogravimetry (TG), differential thermogravimetry (DTG), and differential thermal analysis (DTA) were conducted, followed by the evaluation of AAE decomposition by the UV-Vis spectroscopic method including the influence of temperature and pH. Scavenging, antimicrobial activity and cytotoxicity against L929 fibroblasts were also performed...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28759404/upper-respiratory-infections-and-airway-adverse-events-in-pediatric-procedural-sedation
#4
Michael D Mallory, Curtis Travers, Courtney E McCracken, James Hertzog, Joseph P Cravero
BACKGROUND: Upper respiratory infections (URIs) are associated with airway adverse events (AAEs) during general anesthesia. There have been no large studies examining the relationship between URIs and AAEs during pediatric procedural sedation. We hypothesized that there would be a relationship between URI status and AAEs in pediatric procedural sedation. METHODS: We examined prospectively collected data from the Pediatric Sedation Research Consortium database. Specific questions regarding URI status were added to the database to facilitate our analysis...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28703000/drugan-an-advanced-generative-adversarial-autoencoder-model-for-de-novo-generation-of-new-molecules-with-desired-molecular-properties-in-silico
#5
Artur Kadurin, Sergey Nikolenko, Kuzma Khrabrov, Alex Aliper, Alex Zhavoronkov
Deep generative adversarial networks (GANs) are the emerging technology in drug discovery and biomarker development. In our recent work, we demonstrated a proof-of-concept of implementing deep generative adversarial autoencoder (AAE) to identify new molecular fingerprints with predefined anticancer properties. Another popular generative model is the variational autoencoder (VAE), which is based on deep neural architectures. In this work, we developed an advanced AAE model for molecular feature extraction problems, and demonstrated its advantages compared to VAE in terms of (a) adjustability in generating molecular fingerprints; (b) capacity of processing very large molecular data sets; and (c) efficiency in unsupervised pretraining for regression model...
August 4, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28699859/understanding-the-role-of-micrornas-in-the-interaction-of-aedes-aegypti-mosquitoes-with-an-insect-specific-flavivirus
#6
Morris Lee, Kayvan Etebari, Sonja Hall-Mendelin, Andrew F van den Hurk, Jody Hobson-Peters, Sreenu Vatipally, Esther Schnettler, Roy Hall, Sassan Asgari
The Flavivirus genus contains some of the most prevalent vector-borne viruses, such as the dengue, Zika and yellow fever viruses that cause devastating diseases in humans. However, the insect-specific clade of flaviviruses is restricted to mosquito hosts, albeit they have retained the general features of the genus, such as genome structure and replication. The interactions between insect-specific flaviviruses (ISFs) and their mosquito hosts are largely unknown. Pathogenic flaviviruses are known to modulate host-derived microRNAs (miRNAs), a class of non-coding RNAs that are important in controlling gene expression...
July 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28687105/acquired-c1-inhibitor-deficiency
#7
REVIEW
Iris M Otani, Aleena Banerji
Acquired angioedema due to C1-INH deficiency (C1-INH-AAE) can occur when there are acquired (not inherited) deficiencies of C1-INH. A quantitative or functional C1-INH deficiency with negative family history and low C1q is diagnostic of C1-INH-AAE. The most common conditions associated with C1-INH-AAE are autoimmunity and B-cell lymphoproliferative disorders. A diagnosis of C1-INH-AAE can precede a diagnosis of lymphoproliferative disease and confers an increased risk for developing non-Hodgkin lymphoma. Treatment focuses on symptom control with therapies that regulate bradykinin activity (C1-INH concentrate, icatibant, ecallantide, tranexamic acid, androgens) and treatment of any underlying conditions...
August 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28684135/to-be-blamed-or-pitied-the-effect-of-illness-on-social-behavior-cytokine-levels-and-feed-intake-in-undocked-boars
#8
C Munsterhjelm, J Nordgreen, F Aae, M Heinonen, K Olstad, T Aasmundstad, A M Janczak, A Valros
Tail biting is detrimental to animal welfare and has negative consequences for producer economy. Poor health is one of the risk factors for tail biting. The first aim of this study was therefore to test for links between health status and behavior related to tail biting at the individual level. The second aim of this study was to test whether variation in cytokines was related to variation in social behavior. These small molecules produced upon immune activation are known to influence behavior both in the direction of withdrawal and increased aggression...
July 3, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28669883/high-prices-for-rare-species-can-drive-large-populations-extinct-the-anthropogenic-allee-effect-revisited
#9
Matthew H Holden, Eve McDonald-Madden
Consumer demand for plant and animal products threatens many populations with extinction. The anthropogenic Allee effect (AAE) proposes that such extinctions can be caused by prices for wildlife products increasing with species rarity. This price-rarity relationship creates financial incentives to extract the last remaining individuals of a population, despite higher search and harvest costs. The AAE has become a standard approach for conceptualizing the threat of economic markets on endangered species. Despite its potential importance for conservation, AAE theory is based on a simple graphical model with limited analysis of possible population trajectories...
September 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28667641/optimization-of-pectinase-assisted-and-tri-solvent-mediated-extraction-and-recovery-of-lycopene-from-waste-tomato-peels
#10
Pravin J Munde, Abhijeet B Muley, Mayur R Ladole, Amesh V Pawar, Mohammed I Talib, Vishal R Parate
In the present work, optimization of pectinase-assisted and tri-solvent-mediated extraction of lycopene from waste tomato peels was carried out. The optimized parameters for enzymatic pre-treatment were 2% pectinase concentration, pH 5.5, 4-h incubation, 45 °C and 150 rpm. Maximum recovery of lycopene from tomato peels using optimized tri-solvent extraction was achieved at 45 °C, 120-min incubation and 200 rpm. The extracted lycopene was confirmed through functional and characteristic peaks in UV-Vis and FTIR spectra and with retention time in HPLC...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28665833/why-an-open-disclosure-procedure-is-and-is-not-followed-after-an-avoidable-adverse-event
#11
Irene Carrillo, José Joaquín Mira, Mercedes Guilabert, Susana Lorenzo
OBJECTIVE: The aim of the study was to analyze the relationships between factors that contribute to healthcare professionals informing and apologizing to a patient after an avoidable adverse event (AAE). METHODS: A secondary study based on the analysis of data collected in a cross-sectional study conducted in 2014 in Spain was performed. Health professionals from hospitals and primary care completed an online survey. RESULTS: The responses from 1087 front-line healthcare professionals were analyzed...
June 29, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28662426/first-results-from-light-scattering-enhancement-factor-over-central-indian-himalayas-during-gvax-campaign
#12
U C Dumka, D G Kaskaoutis, Ram Sagar, Jianmin Chen, Narendra Singh, Suresh Tiwari
The present work examines the influence of relative humidity (RH), physical and optical aerosol properties on the light-scattering enhancement factor [f(RH=85%)] over central Indian Himalayas during the Ganges Valley Aerosol Experiment (GVAX). The aerosol hygroscopic properties were measured by means of DoE/ARM (US Department of Energy, Atmospheric Radiation Measurement) mobile facility focusing on periods with the regular instrumental operation (November-December 2011). The measured optical properties include aerosol light-scattering (σsp) and absorption (σap) coefficients and the intensive parameters i...
June 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28638823/comparing-the-effect-of-animal-rearing-education-in-japan-with-conventional-animal-assisted-education
#13
REVIEW
Yuka Nakajima
An increasing number of teachers are introducing animals into their class so that pupils foster cognitive, physiological, and social skills through their interaction with animals. Along with such an educational style termed animal-assisted education (AAE), Japanese formal education has also utilized animals for education. Japanese animal-rearing education is unique regarding the following two points: (1) it takes the form of "education through assisting animals" rather than "animals assisting education" and (2) animal rearing is embedded in formal education...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28634542/angioedema-perioperative-management
#14
Andrew A Maynard, Christina F Burger, Joseph J Schlesinger
OBJECTIVE: To describe the perioperative management of a patient with acquired angioedema (AAE). METHODS: A 66-year-old Caucasian male presented from an outside hospital with a history of acquired angioedema and gastrointestinal stromal tumor-related intractable urticaria and mastocytosis. He was admitted for urgent laparoscopic partial gastrectomy, secondary to gastric outlet obstruction symptomatology. Previous combined attacks were characterized by a widespread rash, abdominal pain and respiratory distress resulting in hospitalization...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28602757/achillea-asiatica-extract-and-its-active-compounds-induce-cutaneous-wound-healing
#15
Banzragch Dorjsembe, Hee Ju Lee, Myungsuk Kim, Batsuren Dulamjav, Tunsag Jigjid, Chu Won Nho
ETHNOPHARMACOLOGICAL RELEVANCE: Achillea asiatica Serg. is a perennial herb belonging to the Asteraceae family that has long been traditionally used to treat acute intestinal and stomach inflammation, persistent fever, ulcers, wounds, and rheumatism. AIM OF THE STUDY: We investigated the effect of A. asiatica extract (AAE) on cutaneous wound healing. MATERIALS AND METHODS: To assess the effect of AAE on wounds, an incisional Sprague-Dawley (SD) rat model was topically treated with AAE for 2 weeks...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28590992/montelukast-treatment-of-acute-asthma-exacerbations-in-children-aged-2-to-5-years-a-randomized-double-blind-placebo-controlled-trial
#16
Xiuping Wang, Jinfang Zhou, Xin Zhao, Xiongxiong Yi
BACKGROUND: Although montelukast has an established role in the management of chronic asthma in children, its efficacy in acute asthma exacerbations (AAEs) in children aged 2 to 5 years is not fully known. This study aimed to evaluate the effectiveness and safety of montelukast for treating AAE in children aged 2 to 5 years in China. METHODS: In total, 120 Chinese children with AAE, aged 2 to 5 years, were randomly divided into 2 groups, each with 60 patients. All patients received either montelukast or placebo along with standard therapy for acute asthma between January 2011 and December 2015...
June 6, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28535440/management-of-ventilator-associated-pneumonia-with-a-new-antibiotic-adjuvant-entity-ceftriaxone-sulbactam-disodium-edetate-a-novel-approach-to-spare-carbapenems
#17
Prachee Sathe, Sagar Maddani, Shilpa Kulkarni, Nita Munshi
BACKGROUND: Ventilator associated pneumonia (VAP) is one of the most serious nosocomial infections in Intensive Care Unit (ICU). The aim of this study was to evaluate a new approach to spare the carbapenems for the management of patients diagnosed with VAP due to Acinetobacter baumannii (A. baumannii). METHOD: This retrospective study was conducted on VAP patients presenting for treatment at tertiary care centre between May 2014 and March 2016. The case sheets of patients who have been treated for VAP with meropenem, antibiotic adjuvant entity (AAE) and colistin were analysed...
May 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28530591/optimization-of-an-organic-yogurt-based-on-sensorial-nutritional-and-functional-perspectives
#18
Ariadne Roberto Karnopp, Katherine Guimarães Oliveira, Eriel Forville de Andrade, Bruna Mara Postingher, Daniel Granato
The effects of purple grape juice (PGJ), grape skin flour (GSF), and oligofructose (OLI) on proximate composition, total phenolic content (TPC), antioxidant activity (AA), sensory, physicochemical, and textural properties of yogurts were analyzed using response surface methodology. Multiple regression models were proposed and results showed that PGJ increased the viscosity, AA, and TPC, while GSF increased the ash and total fiber contents of yogurts. GSF and OLI increased the hardness and consistency. A simultaneous optimization was performed to maximize TPC, ash and fibers contents, and sensory acceptance: a yogurt containing 1...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28528097/protein-digestomic-analysis-reveals-the-bioactivity-of-deer-antler-velvet-in-simulated-gastrointestinal-digestion
#19
Yang Yu, Yan Jin, Fangjun Wang, Jiaze Yan, Yanxia Qi, Mingliang Ye
Proteins are the most prominent bioactive component in deer antler velvet. The aim of the present study was to track the fate of protein of antler velvet by protein digestomics. The peptide profile identified by LC-MS/MS and the in vitro bioactivity of antler velvet aqueous extract (AAE) were investigated in simulated gastrointestinal digestion. A total of 23, 387 and 417 peptides in AAE, gastric and pancreatic digests were identified using LC-MS/MS, respectively. Collagens, the predominant proteins, released 34 peptides in gastric digests and 146 peptides in pancreatic digests...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28521835/adult-autoimmune-enteropathy-presenting-initially-with-acquired-acrodermatitis-enteropathica-a-case-report
#20
Erina Lie, Sarah Sung, Steven Hoseong Yang
BACKGROUND: Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, acquired AE (AAE) is often secondary to underlying pathologic or iatrogenic etiologies that interfere with nutritional absorption, such as inflammatory bowel disease or alcoholism. Various gastrointestinal pathologies have been associated with AAE, but there is currently no report on its association with adult autoimmune enteropathy (AIE), a rare gastrointestinal disorder commonly seen in infants, with limited cases reported in adults...
May 18, 2017: BMC Dermatology
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