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Chan Gao, Xueyong Zhang, Chuanchao Zhang, Zhilei Sui, Meng Hou, Rucheng Dai, Zhongping Wang, Xianxu Zheng, Zengming Zhang
Herein, pressure-induced phase transitions of RDX up to 50 GPa were systematically studied under different compression conditions. Precise phase transition points were obtained based on high-quality Raman spectra with small pressure intervals. This favors the correctness of the theoretical formula for detonation and the design of a precision weapon. The experimental results indicated that α-RDX immediately transformed to γ-RDX at 3.5 GPa due to hydrostatic conditions and possible interaction between the penetrating helium and RDX, with helium gas as the pressure-transmitting medium (PTM)...
May 17, 2018: Physical Chemistry Chemical Physics: PCCP
Giovanni Merolla, Simone Cerciello, Stefano Marenco, Elisabetta Fabbri, Paolo Paladini, Giuseppe Porcellini
PURPOSE: We hypothesized that osteoarthritis developing after instability surgery is radiographically similar to primary arthritis and that arthroplasty provides comparable outcomes in patients with these two types of osteoarthritis. METHODS: Patients with osteoarthritis due to instability surgery (group I) and with primary osteoarthritis (group II) were included. Mean follow-up was 52.6 and 41.6 months, respectively. Hemiarthroplasties (HA) were 32% in group I and 27% in group II; total shoulder arthroplasties (TSA) were 68 and 73% respectively...
May 12, 2018: International Orthopaedics
Rahman Md Moshikur, Chowdhury Md Raihan, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto
The technological utility of active pharmaceutical ingredients (APIs) is greatly enhanced when they are transformed into ionic liquids (ILs). API-ILs have better solubility, thermal stability, and the efficacy in topical delivery than solid or crystalline drugs. However, toxicological issue of API-ILs is the main challenge for their application in drug delivery. To address this issue, 11 amino acid esters (AAEs) were synthesized and investigated as biocompatible counter cations for the poorly water-soluble drug salicylic acid (Sal) to form Sal-ILs...
May 8, 2018: International Journal of Pharmaceutics
Chandan Raychaudhury, Md Imbesat Hassan Rizvi, Debnath Pal
BACKGROUND: Generating a large number of compounds using combinatorial methods increases the possibility of finding novel bioactive compounds. Although some combinatorial structure generation algorithms are available, any method for generating structures from activity-linked substructural topological information is not yet reported. OBJECTIVE: To develop a method using graph-theoretical techniques for generating structures of antitubercular compounds combinatorially from activity-linked substructural topological information, predict activity and prioritize and screen potential drug candidates...
May 9, 2018: Current Computer-aided Drug Design
Ping Wang, Babykumari Chitramuthu, Andrew Bateman, Hugh P J Bennett, Ping Xu, Feng Ni
The ancient and pluripotent progranulins contain multiple repeats of a cysteine-rich sequence motif of ∼60 amino acids, called the granulin/epithelin module (GEM) with a prototypic structure of four β-hairpins zipped together by six inter-hairpin disulfide bonds. Prevalence of this disulfide-enforced structure is assessed here by an expression screening of 19 unique GEM sequences of the four progranulins in the zebrafish genome, progranulins 1, 2, A and B. While a majority of the expressed GEM peptides did not exhibit uniquely-folded conformations, module AaE from progranulin A and AbB from progranulin B were found to fold into the protopypic 4-hairpin structure along with disulfide formation...
May 7, 2018: Protein Science: a Publication of the Protein Society
Emel Aygören-Pürsün, Markus Magerl, Andreas Maetzel, Marcus Maurer
BACKGROUND: Bradykinin-mediated angioedema (Bk-AE) can be life-threatening and requires specific targeted therapies. Knowledge of its epidemiology may help optimize its management. METHODS: We systematically searched the medical literature to identify abstracts of interest indexed between 1948 and March, 2016. We used published national survey data on the proportion of the population treated with angiotensin-converting enzyme inhibitors (ACEI) to derive estimates of the population prevalence of ACEI-AE in the USA, Germany and France...
May 4, 2018: Orphanet Journal of Rare Diseases
Young-Ji Choi, In-Sun Park, Mi-Hee Kim, Bora Kwon, Young-Moo Choo, Seung-Il Jeong, Kang-Yeol Yu, Chung Hyeon Choe, Jiyoung Kim
In this study, Auricularia auricula-judae (Bull.) extract (AAE) had potent antioxidant activity in vitro and promoted the biosynthesis of procollagen, a precursor of collagen in HaCaT cells. In addition, the expression of HAS-3 (hyaluronic acid synthase), which is a moisturizing factor, was increased in HaCaT cells in response to AAE. Therefore, this work suggests that AAE has the potential to exhibit antioxidant activity and promote procollagen biosynthesis in HaCaT cells.
May 4, 2018: Natural Product Research
Noémi Andrási, Nóra Veszeli, Kinga Viktória Kőhalmi, Dorottya Csuka, György Temesszentandrási, Lilian Varga, Henriette Farkas
BACKGROUND: The mechanism of idiopathic non-histaminergic acquired angioedema (InH-AAE) has not yet been precisely elucidated. This condition is characterized by recurrent angioedema without wheals. OBJECTIVE: To study the clinical features of InH-AAE, and to make, for the first time, independent comparisons with hereditary angioedema of unknown origin (U-HAE), as well as with hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE). METHODS: We compared the clinical parameters of 46 InH-AAE patients to those of 27 patients suffering from U-HAE, as well as of 73 patients with C1-INH-HAE...
April 28, 2018: Journal of Allergy and Clinical Immunology in Practice
Maryam Gharibzadeh, Khan Alam, Yousefali Abedini, Abbasali Aliakbari Bidokhti, Amir Masoumi, Humera Bibi
Discrimination of aerosol types is very important, because different aerosols are created from diverse sources having different chemical, physical, and optical properties. In the present study, we have analyzed the seasonal classification of aerosol types by multiple clustering techniques, using AERosol Robotic NETwork (AERONET) data during 2010-2013 over Zanjan, Iran. We found that aerosol optical depth (AOD) showed pronounced seasonal variations of a summer high and winter low. Conversely, the values of the Angstrom exponent (AE) in winter and fall were higher than in spring and summer, which confirmed the presence of fine particles, while the low value of AE in the summer and spring represented the existence of coarse particles...
April 10, 2018: Applied Optics
In Sil Jeong, Youngjin Park, Hyun Aae Ryu, Hyun Sook An, Ju Hye Han, Sung-Whan Kim
No abstract text is available yet for this article.
April 18, 2018: International Journal of Cardiology
C Jacquin-Porretaz, F Castelain, E Daguindau, E Seilles, C Nardin, F Aubin, F Pelletier
BACKGROUND: Acquired C1-esterase inhibitor (C1-INH) deficiency angioedema (C1-INH-AAE) is a form of bradykinin-mediated angioedema. This rare disorder is due to acquired consumption of C1-INH, hyperactivation of the classic pathway of human complement, and potentially fatal recurrent angioedema symptoms. Clinical symptoms of C1-INH-AAE are very similar to those of hereditary angioedema (HAE) but usually appear after the fourth decade of life and induce abdominal pain less frequently. Laboratory tests are essential in establishing the diagnosis with low levels or abnormal structure and function of C1-INH...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
Younggeul Min, Seongho Han, Hyun Aae Ryu, Sung-Whan Kim
Aims: In present study, we sought to characterize the angio-vasculogenic property of human adipose mesenchymal stem cells (ASCs) overexpressing dual chemokine GCP-2 and SDF-1α (ASC-G/S) and to determine the therapeutic potential of ASC-G/S in the context of experimental ischemia. Methods and results: We generated ASC-G/S line and performed flow cytometry, quantitative (q)-PCR, Matrigel tube formation, Matrigel plug assays and in vivo therapeutic assays using hind limb ischemia mouse model...
April 5, 2018: Cardiovascular Research
Julie A Washington, Lee Branum-Martin, Congying Sun, Ryan Lee-James
Purpose: The goal of the current study was to examine the impact of dialect density on the growth of oral language and reading skills in a sample of African American English (AAE)-speaking children reared in urban communities. Method: Eight hundred thirty-five African American children in first through fifth grades participated. Using an accelerated cohort design, univariate and bivariate growth models were employed to examine dialect density, oral language and reading, and the relationships between these variables...
April 5, 2018: Language, Speech, and Hearing Services in Schools
Muamer Dizdar, Danijela Vidic, Franc Požgan, Bogdan Štefane, Milka Maksimović
Phenolic acids and their derivatives found in nature are well-known for their potential biological activity. In this study, two amides derived from trans -caffeic/ferulic acid and dopamine were synthesized and characterized by Fourier-transform infrared spectroscopy (FTIR), mass spectrometry, proton and carbon-13 nuclear magnetic resonance spectroscopy. The compounds were tested for the inhibition of acetylcholinesterase (AChE) from Electrophorus electricus and for antioxidant activity by scavenging 2,2-diphenyl-1-pycrylhydrazyl free radical (DPPH• ) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) radical cation (ABTS•+ ), reducing ferric ions, and ferrous ions chelation...
April 4, 2018: Scientia Pharmaceutica
Bhumi Parikh, V H Patel
Pulses are valued for their protein content and are good source of bioactive phytochemicals. The objectives of this study were to estimate total phenolic content (TPC), flavonoid content and total antioxidant capacity (TAC) through six different assay methods from twenty seven different varieties of pulses and split pulses commonly consumed in India. TPC and flavonoid content ranged between 38.6-542.7 mg GAE/100 g and 18.3-344.7 mg RE/100 g respectively. TAC measured by FRAP (90.6-2773.5 mg TE/100 g), RPA (190...
April 2018: Journal of Food Science and Technology
Syeda Tayyaba Batool Kazmi, Muhammad Majid, Sonia Maryam, Aymen Rahat, Madiha Ahmed, Muhammad Rashid Khan, Ihsan Ul Haq
Quercus dilatata Lindl. ex Royle was evaluated for in vitro polyphenol content and antioxidant potential as well as in vivo protective role against bisphenol A (BPA) induced hepatotoxicity. The distilled water-acetone (QDDAE) and methanol-ethyl acetate (QDMEtE) extracts were standardized and administered in high (300 mg/kg body weight (BW) and low (150 mg/kg BW) doses to Sprague Dawley rats, injected with BPA (25 mg/kg BW). Silymarin (50 mg/kg BW) was used as positive control. Subsequently, blood and liver homogenates were collected after four weeks of treatment, and the defensive effects of both extracts against oxidative damage and genotoxicity were assessed via hematological and biochemical investigations, determination of endogenous expression of enzymes as well as levels of free radicals and comet assay...
March 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ying Wei, Feng Lu, Tiege Zhou, Xiaoguang Luo, Yuanchun Zhao
Possible bulk black phosphorus (BP) allotropes are constructed based on single-layer BP with various stacking sequences. Our stacking algorithm shows that there are eight possible allotropes with two stacking layers in their unit cells possessing relatively high symmetries, and six of them are retained after structural relaxation using a van der Waals correction of optB88-vdW. The AF, AG, and AH bulk structures are presented for the first time. The structural relationship of these configurations has been explained via an interlayer slipping process...
March 29, 2018: Physical Chemistry Chemical Physics: PCCP
Ángel Pérez-Silvestre, Daniel Albert-Lucena, Guido F Gómez-Chiguano, Gustavo Plaza-Manzano, Daniel Pecos-Martín, Tomás Gallego-Izquierdo, Patricia Martín-Casas, Natalia Romero-Franco
BACKGROUND: Proprioception and vertical jump are important parameters in the performance and prevention of injuries in futsal. However, very few studies have analyzed the role of multi-station exercises to improve these variables. The purpose of this study was to assess the effects of a six-week multi-station exercise program on knee joint position sense (JPS) and countermovement jump (CMJ) of futsal players. METHODS: Thirty-four male futsal players randomly classified into experimental (n = 17) or control group (n = 17)...
March 27, 2018: Journal of Sports Medicine and Physical Fitness
Robert Schierwagen, Camila Alvarez-Silva, Mette Simone Aae Madsen, Carl Christian Kolbe, Carsten Meyer, Daniel Thomas, Frank Erhard Uschner, Fernando Magdaleno, Christian Jansen, Alessandra Pohlmann, Michael Praktiknjo, Gunnar T Hischebeth, Ernst Molitor, Eicke Latz, Benjamin Lelouvier, Jonel Trebicka, Manimozhiyan Arumugam
No abstract text is available yet for this article.
March 26, 2018: Gut
Juliane Horvath, Tilman Steinert, Susanne Jaeger
BACKGROUND: Despite the major encroachment of coercive measures on the fundamental rights of affected forensic psychiatric patients, there is relatively few research done in this field. Considering the relevance of this subject for psychiatric care and the recent changes of the legal basis of coercive treatment in Germany, more studies are needed. The present study examines forensic psychiatric inpatients' perception of coercion regarding the prescribed antipsychotic medication and factors associated with the perception of coercion...
March 2018: International Journal of Law and Psychiatry
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