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https://www.readbyqxmd.com/read/28901345/-acute-alcoholic-hepatitis
#1
Gianni Testino, Emanuele Scafato, Valentino Patussi
Chronic alcohol related liver disease is characterized by a cascade of events defined as follows: steatosis, steatohepatitis/steatofibrosi, cirrhosis and hepatocellular carcinoma. On one of these histologic patterns may overlap acute alcoholic hepatitis (AAE) (mild, moderate, severe). Severe AAE can cause a severe clinical picture: jaundice with a duration of less than three months, jaundice in the first decompensation event, serum bilirubin higher than 5 mg/dL, ratio AST/ALT >2:1, AST less than 500 IU/L ALT <300 IU/L, neutrophil leukocytosis and increased GGT...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28873617/nutritional-and-bioactive-potential-of-myrtaceae-fruits-during-ripening
#2
Siluana Katia Tischer Seraglio, Mayara Schulz, Priscila Nehring, Fabiana Della Betta, Andressa Camargo Valese, Heitor Daguer, Luciano Valdemiro Gonzaga, Roseane Fett, Ana Carolina Oliveira Costa
This study aimed to characterize jabuticaba (Myrciaria cauliflora), guabiju (Myrcianthes pungens), and jambolan (Syzygium cumini) in relation to its individual phenolic compounds (LC-ESI-MS/MS), antioxidant capacity, total monomeric anthocyanin, sugars, and minerals during ripening (intermediate and ripe stages). In the three studied fruits, 22 phenolic compounds were quantified, especially phenolic acids and flavonoids, which presented a higher concentration in the intermediate ripening stage. In contrast, the total monomeric anthocyanin, fructose, glucose, Ca, Na values were higher in the ripe stage...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28870197/polarity-based-characterization-of-biologically-active-extracts-of-ajuga-bracteosa-wall-ex-benth-and-rp-hplc-analysis
#3
Syeda Saniya Zahra, Madiha Ahmed, Muhammad Qasim, Bilquees Gul, Muhammad Zia, Bushra Mirza, Ihsan-Ul Haq
BACKGROUND: The concept of botanical therapeutics has revitalized due to wide importance of plant derived pharmaceuticals. Therefore, the ameliorative characteristics of Ajuga bracteosa were studied. METHODS: Total phenolic content, flavonoid content, antioxidant capacity, reducing power and free-radical scavenging activity were determined colorimetrically. Specific polyphenols were quantified by RP-HPLC analysis. Preliminary cytotoxicity was tested using brine shrimp lethality assay while antiproliferative activity against THP-1 and Hep-G2 cell lines was determined by MTT and SRB protocols respectively...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28867094/antioxidant-properties-of-selected-fruit-cultivars-grown-in-sri-lanka
#4
K D R R Silva, M S F Sirasa
Extracts of twenty locally available Sri Lankan fruits were analysed for 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferrous reducing antioxidant power (FRAP), total phenolic content (TPC), total flavonoid content (TFC) and vitamin C content. The results showed that gooseberry (Phyllanthus emblica 'local') exhibited the highest DPPH scavenging activity (111.25mg ascorbic acid equivalent antioxidant capacity (AEAC)/g), FRAP (1022.05μmol FeSO4/g), TPC (915.7mg gallic acid equivalents (GAE)/100g), TFC (873...
January 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28861213/idiopathic-non-histaminergic-acquired-angioedema-a-case-series-and-discussion-of-published-clinical-trials
#5
Martin Christian Bucher, Tatjana Petkovic, Arthur Helbling, Urs Christian Steiner
BACKGROUND: Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease for which there are no available laboratory parameters to clearly define the disorder. Therapy is often difficult and various treatment options have been proposed. In this paper, we have evaluated the most effective therapies for InH-AAE on the basis of current literature and report the therapeutic effect of omalizumab in three patients with InH-AAE. METHODS: Literature was searched with a combination of MeSH/EMTREE terms and freetext search for angioedema and therapy/omalizumab in the databases Medline (Ovid), PubMed/Premedline, Embase, Cochrane library and Scopus with no time or language restrictions...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28855038/-effect-of-scanning-and-reconstruction-parameters-on-three-dimensional-volume-and-ct-value-measurement-of-pulmonary-nodules-a-phantom-study
#6
Datong Su, Lei Feng, Yingjian Jiang, Ying Wang
BACKGROUND: The computed tomography (CT) follow-up of indeterminate pulmonary nodules aiming to evaluate the change of the volume and CT value is the common strategy in clinic. The CT dose needs to considered on serious CT scans in addition to the measurement accuracy. The purpose of this study is to quantify the precision of pulmonary nodule volumetric measurement and CT value measurement with various tube currents and reconstruction algorithms in a phantom study with dual-energy CT...
August 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28844305/regenerative-endodontics-for-adult-patients
#7
Ling He, Sahng G Kim, Qimei Gong, Juan Zhong, Sainan Wang, Xuedong Zhou, Ling Ye, Junqi Ling, Jeremy J Mao
The goal of endodontics is to save teeth. Since inception, endodontic treatments are performed to obturate disinfected root canals with inert materials such as gutta-percha. Although teeth can be saved after successful endodontic treatments, they are devitalized and therefore susceptible to reinfections and fractures. The American Association of Endodontists (AAE) has made a tremendous effort to revitalize disinfected immature permanent teeth in children and adolescents with diagnoses including pulp necrosis or apical periodontitis...
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28844223/aae-position-statement-aae-guidance-on-the-use-of-systemic-antibiotics-in-endodontics
#8
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28827984/ramalina-capitata-ach-nyl-acetone-extract-hplc-analysis-genotoxicity-cholinesterase-antioxidant-and-antibacterial-activity
#9
Ivana Zrnzevic, Miroslava Stankovic, Vesna Stankov Jovanovic, Violeta Mitic, Aleksandra Dordevic, Ivana Zlatanovic, Gordana Stojanovic
In the present investigation, effects of Ramalina capitata acetone extract on micronucleus distribution on human lymphocytes, on cholinesterase activity and antioxidant activity (by the CUPRAC method) were examined, for the first time as well as its HPLC profile. Additionally, total phenolic compounds (TPC), antioxidant properties (estimated via DPPH, ABTS and TRP assays) and antibacterial activity were determined. The predominant phenolic compounds in this extract were evernic, everninic and obtusatic acids...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28774308/polarity-directed-optimization-of-phytochemical-and-in-vitro-biological-potential-of-an-indigenous-folklore-quercus-dilatata-lindl-ex-royle
#10
Madiha Ahmed, Humaira Fatima, Muhammad Qasim, Bilquees Gul, Ihsan-Ul-Haq
BACKGROUND: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, cytotoxic, protein kinase inhibitory, antileishmanial and glucose modulatory attributes of a Himalayan medicinal plant- Quercus dilatata. METHODS: Total phenolic and flavonoid contents were determined colorimetrically and various polyphenols were identified by RP-HPLC analysis...
August 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28770462/predictive-value-of-18-f-fdg-pet-ct-in-patients-with-acute-type-b-aortic-intramural-hematoma
#11
Fan Yang, Jianfang Luo, Qingyi Hou, Nianjin Xie, Zhiqiang Nie, Wenhui Huang, Yuan Liu, Yingling Zhou, Jiyan Chen, Qingshan Geng
BACKGROUND: The clinical course and predictors of adverse aortic events (AAE) in patients with acute Stanford type B intramural hematoma (IMH) remain controversial. This study aimed to investigate whether (18)F-FDG PET/CT can predict risk in patients with acute type B IMH. METHODS AND RESULTS: This study included 34 patients with acute type B IMH who underwent PET/CT within 14 days from the onset of symptoms. The maximal standardized uptake values (SUVmax) of (18)F-FDG uptake was significantly different between patients with or without AAE (4...
August 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28769001/selected-physicochemical-and-biological-properties-of-ethyl-ascorbic-acid-compared-to-ascorbic-acid
#12
Iwona Golonka, Monika Oleksy, Adam Junka, Agnieszka Matera-Witkiewicz, Marzenna Bartoszewicz, Witold Musiał
The aim of the work was the evaluation of selected biological and physicochemical, applicative properties of ethylated ascorbic acid (AAE) compared to ascorbic acid (AA). Thermogravimetry (TG), differential thermogravimetry (DTG), and differential thermal analysis (DTA) were conducted, followed by the evaluation of AAE decomposition by the UV-Vis spectroscopic method including the influence of temperature and pH. Scavenging, antimicrobial activity and cytotoxicity against L929 fibroblasts were also performed...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28759404/upper-respiratory-infections-and-airway-adverse-events-in-pediatric-procedural-sedation
#13
Michael D Mallory, Curtis Travers, Courtney E McCracken, James Hertzog, Joseph P Cravero
BACKGROUND: Upper respiratory infections (URIs) are associated with airway adverse events (AAEs) during general anesthesia. There have been no large studies examining the relationship between URIs and AAEs during pediatric procedural sedation. We hypothesized that there would be a relationship between URI status and AAEs in pediatric procedural sedation. METHODS: We examined prospectively collected data from the Pediatric Sedation Research Consortium database. Specific questions regarding URI status were added to the database to facilitate our analysis...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28703000/drugan-an-advanced-generative-adversarial-autoencoder-model-for-de-novo-generation-of-new-molecules-with-desired-molecular-properties-in-silico
#14
Artur Kadurin, Sergey Nikolenko, Kuzma Khrabrov, Alex Aliper, Alex Zhavoronkov
Deep generative adversarial networks (GANs) are the emerging technology in drug discovery and biomarker development. In our recent work, we demonstrated a proof-of-concept of implementing deep generative adversarial autoencoder (AAE) to identify new molecular fingerprints with predefined anticancer properties. Another popular generative model is the variational autoencoder (VAE), which is based on deep neural architectures. In this work, we developed an advanced AAE model for molecular feature extraction problems, and demonstrated its advantages compared to VAE in terms of (a) adjustability in generating molecular fingerprints; (b) capacity of processing very large molecular data sets; and (c) efficiency in unsupervised pretraining for regression model...
August 4, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28699859/understanding-the-role-of-micrornas-in-the-interaction-of-aedes-aegypti-mosquitoes-with-an-insect-specific-flavivirus
#15
Morris Lee, Kayvan Etebari, Sonja Hall-Mendelin, Andrew F van den Hurk, Jody Hobson-Peters, Sreenu Vatipally, Esther Schnettler, Roy Hall, Sassan Asgari
The Flavivirus genus contains some of the most prevalent vector-borne viruses, such as the dengue, Zika and yellow fever viruses that cause devastating diseases in humans. However, the insect-specific clade of flaviviruses is restricted to mosquito hosts, albeit they have retained the general features of the genus, such as genome structure and replication. The interactions between insect-specific flaviviruses (ISFs) and their mosquito hosts are largely unknown. Pathogenic flaviviruses are known to modulate host-derived microRNAs (miRNAs), a class of non-coding RNAs that are important in controlling gene expression...
July 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28687105/acquired-c1-inhibitor-deficiency
#16
REVIEW
Iris M Otani, Aleena Banerji
Acquired angioedema due to C1-INH deficiency (C1-INH-AAE) can occur when there are acquired (not inherited) deficiencies of C1-INH. A quantitative or functional C1-INH deficiency with negative family history and low C1q is diagnostic of C1-INH-AAE. The most common conditions associated with C1-INH-AAE are autoimmunity and B-cell lymphoproliferative disorders. A diagnosis of C1-INH-AAE can precede a diagnosis of lymphoproliferative disease and confers an increased risk for developing non-Hodgkin lymphoma. Treatment focuses on symptom control with therapies that regulate bradykinin activity (C1-INH concentrate, icatibant, ecallantide, tranexamic acid, androgens) and treatment of any underlying conditions...
August 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28684135/to-be-blamed-or-pitied-the-effect-of-illness-on-social-behavior-cytokine-levels-and-feed-intake-in-undocked-boars
#17
C Munsterhjelm, J Nordgreen, F Aae, M Heinonen, K Olstad, T Aasmundstad, A M Janczak, A Valros
Tail biting is detrimental to animal welfare and has negative consequences for producer economy. Poor health is one of the risk factors for tail biting. The first aim of this study was therefore to test for links between health status and behavior related to tail biting at the individual level. The second aim of this study was to test whether variation in cytokines was related to variation in social behavior. These small molecules produced upon immune activation are known to influence behavior both in the direction of withdrawal and increased aggression...
July 3, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28669883/high-prices-for-rare-species-can-drive-large-populations-extinct-the-anthropogenic-allee-effect-revisited
#18
Matthew H Holden, Eve McDonald-Madden
Consumer demand for plant and animal products threatens many populations with extinction. The anthropogenic Allee effect (AAE) proposes that such extinctions can be caused by prices for wildlife products increasing with species rarity. This price-rarity relationship creates financial incentives to extract the last remaining individuals of a population, despite higher search and harvest costs. The AAE has become a standard approach for conceptualizing the threat of economic markets on endangered species. Despite its potential importance for conservation, AAE theory is based on a simple graphical model with limited analysis of possible population trajectories...
September 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28667641/optimization-of-pectinase-assisted-and-tri-solvent-mediated-extraction-and-recovery-of-lycopene-from-waste-tomato-peels
#19
Pravin J Munde, Abhijeet B Muley, Mayur R Ladole, Amesh V Pawar, Mohammed I Talib, Vishal R Parate
In the present work, optimization of pectinase-assisted and tri-solvent-mediated extraction of lycopene from waste tomato peels was carried out. The optimized parameters for enzymatic pre-treatment were 2% pectinase concentration, pH 5.5, 4-h incubation, 45 °C and 150 rpm. Maximum recovery of lycopene from tomato peels using optimized tri-solvent extraction was achieved at 45 °C, 120-min incubation and 200 rpm. The extracted lycopene was confirmed through functional and characteristic peaks in UV-Vis and FTIR spectra and with retention time in HPLC...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28665833/why-an-open-disclosure-procedure-is-and-is-not-followed-after-an-avoidable-adverse-event
#20
Irene Carrillo, José Joaquín Mira, Mercedes Guilabert, Susana Lorenzo
OBJECTIVE: The aim of the study was to analyze the relationships between factors that contribute to healthcare professionals informing and apologizing to a patient after an avoidable adverse event (AAE). METHODS: A secondary study based on the analysis of data collected in a cross-sectional study conducted in 2014 in Spain was performed. Health professionals from hospitals and primary care completed an online survey. RESULTS: The responses from 1087 front-line healthcare professionals were analyzed...
June 29, 2017: Journal of Patient Safety
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