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BMO and optic disc and OCT

Philip Enders, Werner Adler, Friederike Schaub, Manuel M Hermann, Thomas Dietlein, Claus Cursiefen, Ludwig M Heindl
Purpose: The purpose of this study was to assess the diagnostic power of the novel two-dimensional parameter Bruch's membrane opening minimal rim area (BMO-MRA) in spectral-domain optical coherence tomography (SD-OCT) for detection of glaucoma compared to minimal rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in large and small optic discs. Methods: In this case-control, cross-sectional study, 207 eyes of 207 participants, including 89 controls and 97 patients with glaucoma and 21 with ocular hypertension (OHT), with a disc size <1...
December 1, 2016: Investigative Ophthalmology & Visual Science
Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Makoto Araie, Shin Yoneya
PURPOSE: Morphological features of the lamina cribrosa (LC) and optic disc may be important in the pathogenesis of glaucoma and myopic neuropathy. We therefore performed a cross-sectional study of patients with glaucoma and myopic neuropathy to evaluate vertical asymmetry of LC tilt angles (LCTAs) from Bruch's membrane opening (BMO). MATERIAL AND METHODS: Forty-six control eyes and 35 primary open-angle glaucoma (POAG) eyes were included. A raster scanning protocol with 300 single B-scans (without averaging) were obtained using optical coherence tomography with a wide-bandwidth, femtosecond mode-locked (ML) laser...
January 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
Anani P Toshev, Julia Lamparter, Norbert Pfeiffer, Esther M Hoffmann
PURPOSE: To compare the diagnostic performance and evaluate diagnostic agreement for early glaucoma detection between a confocal scanning laser ophthalmoscope (CSLO) and a spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Fifty-five eyes of 55 open-angle glaucoma patients and 42 eyes of 42 healthy control subjects were enrolled in this observational, cross-sectional study. All participants underwent comprehensive ophthalmic examination, visual field testing, and optic nerve head and retinal nerve fiber layer imaging by CSLO (HRT3) and SD-OCT (Spectralis OCT)...
January 2017: Journal of Glaucoma
Eun Ji Lee, Kyoung Min Lee, Hyunjoong Kim, Tae-Woo Kim
PURPOSE: To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic disc. METHODS: In 75 eyes with primary open-angle glaucoma (POAG) and 71 healthy control eyes, circumpapillary RNFL thickness was measured with SD-OCT, first by centering the scan circle on the optic disc (RNFLDi), and then on the BMO (RNFLBMO)...
August 1, 2016: Investigative Ophthalmology & Visual Science
Aarti Patel, Ravi Purohit, Helena Lee, Viral Sheth, Gail Maconachie, Eleni Papageorgiou, Rebecca J McLean, Irene Gottlob, Frank A Proudlock
PURPOSE: To determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective cross-sectional study. PARTICIPANTS: Three hundred fifty-two children aged between 1 day and 13 years. METHODS: All participants were imaged using handheld SD OCT without sedation during a single scan session...
October 2016: Ophthalmology
Philip Enders, Friederike Schaub, Werner Adler, Roman Nikoluk, Manuel M Hermann, Ludwig M Heindl
PURPOSE: To assess the performance of Bruch's membrane opening (BMO)-based spectral domain optical coherence tomography (SD-OCT) of the optic nerve head for glaucoma detection in microdiscs in comparison with confocal scanning laser tomography (CSLT). DESIGN: Retrospective cohort study. METHODS: 82 eyes of 82 patients with disc size <1.63 mm(2) underwent SD-OCT and CSLT measurements, visual field testing and clinical examination. BMO-based minimal rim width (BMO-MRW), retinal nerve fibre layer thickness (RNFLT) in SD-OCT and rim area measured in CSLT were compared and correlated with visual field defects...
July 19, 2016: British Journal of Ophthalmology
Philip Enders, Friederike Schaub, Manuel M Hermann, Claus Cursiefen, Ludwig M Heindl
BACKGROUND/AIMS: To compare margin-based rim area measurements from confocal scanning laser tomography (CSLT) with Bruch's membrane opening (BMO)-based measurements from spectral domain optical coherence tomography (SD-OCT) by analysis of a group of non-glaucomatous eyes with large optic discs, so-called macrodiscs (disc size >2.45 mm(2) in CSLT). Objective is to create a reference base for large optic nerve heads in SD-OCT diagnostics. METHODS: 102 eyes received CSLT and SD-OCT measurements and clinical examination on the same day...
April 26, 2016: British Journal of Ophthalmology
Rizwan Malik, Anne C Belliveau, Glen P Sharpe, Lesya M Shuba, Balwantray C Chauhan, Marcelo T Nicolela
PURPOSE: Ruling out glaucoma in myopic eyes often poses a diagnostic challenge because of atypical optic disc morphology and visual field defects that can mimic glaucoma. We determined whether neuroretinal rim assessment based on Bruch's membrane opening (BMO), rather than conventional optic disc margin (DM)-based assessment or retinal nerve fiber layer (RNFL) thickness, yielded higher diagnostic accuracy in myopic patients with glaucoma. DESIGN: Case-control, cross-sectional study...
June 2016: Ophthalmology
Paul Gerard Sanfilippo, Emily Huynh, Seyhan Yazar, Alex William Hewitt, David Anthony Mackey
PURPOSE: To characterize and quantify Bruch membrane opening (BMO)-based optic nerve head (ONH) parameters in a large, young and healthy, predominantly white population. DESIGN: Cross-sectional study and reliability analysis. METHODS: The ONH of 1344 predominantly white subjects were imaged with spectral-domain optical coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to manually segment and measure multiple BMO-based parameters of the ONH...
May 2016: American Journal of Ophthalmology
Yu Sawada, Masanori Hangai, Katsuyuki Murata, Makoto Ishikawa, Takeshi Yoshitomi
PURPOSE: To study lamina cribrosa (LC) depth variation measured by spectral-domain optical coherence tomography (SD-OCT) in four glaucomatous optic disc phenotypes. METHODS: In this cross-sectional study, 59 normal eyes and 180 open-angle glaucoma (OAG) eyes were grouped into 56 focally injured discs (FI), 30 generalized enlargement of the optic cup discs (GE), 69 myopic glaucomatous discs (MY), and 25 senile sclerotic discs (SS). They were imaged by enhanced depth imaging SD-OCT, obtaining multiple horizontal and vertical optic disc B-scans...
September 2015: Investigative Ophthalmology & Visual Science
Balwantray C Chauhan, Vishva M Danthurebandara, Glen P Sharpe, Shaban Demirel, Christopher A Girkin, Christian Y Mardin, Alexander F Scheuerle, Claude F Burgoyne
PURPOSE: Conventional optic disc margin-based neuroretinal rim measurements lack a solid anatomic and geometrical basis. An optical coherence tomography (OCT) index, Bruch's membrane opening minimum rim width (BMO-MRW), addresses these deficiencies and has higher diagnostic accuracy for glaucoma. We characterized BMO-MRW and peripapillary retinal nerve fiber layer thickness (RNFLT) in a normal population. DESIGN: Multicenter cross-sectional study. PARTICIPANTS: Normal white subjects...
September 2015: Ophthalmology
Sri Gowtham Thakku, Yih-Chung Tham, Mani Baskaran, Jean-Martial Mari, Nicholas G Strouthidis, Tin Aung, Ching-Yu Cheng, Michael J A Girard
PURPOSE: Lamina cribrosa (LC) morphology could be implicated in the progression of glaucoma. To date, no established, quantifiable parameter to assess LC shape in vivo exists. We aim to introduce a new global shape index for the anterior LC (LC-GSI) and to identify associations with ocular factors in a healthy Indian population. METHODS: Optical coherence tomography (OCT) scans of the optic nerve head (ONH) were performed on 162 healthy subjects. Optic nerve head structures were delineated and a geometric characterization of anterior LC morphology was obtained by measuring curvature along 180 LC cross sections and representing it as LC-GSI ranging from -1 to +1...
June 2015: Investigative Ophthalmology & Visual Science
Tin A Tun, Chen-Hsin Sun, Mani Baskaran, Michael J A Girard, John Mark S de Leon, Ching-Yu Cheng, Hla M Htoon, Tien Y Wong, Tin Aung, Nicholas G Strouthidis
PURPOSE: To characterize an optical coherence tomography (OCT)-derived parameter, Bruch's membrane opening-minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects. METHODS: Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm...
May 2015: Investigative Ophthalmology & Visual Science
Mohammad Saleh Miri, Michael D Abràmoff, Kyungmoo Lee, Meindert Niemeijer, Jui-Kai Wang, Young H Kwon, Mona K Garvin
In this work, a multimodal approach is proposed to use the complementary information from fundus photographs and spectral domain optical coherence tomography (SD-OCT) volumes in order to segment the optic disc and cup boundaries. The problem is formulated as an optimization problem where the optimal solution is obtained using a machine-learning theoretical graph-based method. In particular, first the fundus photograph is registered to the 2D projection of the SD-OCT volume. Three in-region cost functions are designed using a random forest classifier corresponding to three regions of cup, rim, and background...
September 2015: IEEE Transactions on Medical Imaging
Akram Belghith, Christopher Bowd, Robert N Weinreb, Linda M Zangwill
Glaucoma is a chronic neurodegenerative disease characterized by loss of retinal ganglion cells, resulting in distinctive changes in the optic nerve head (ONH) and retinal nerve fiber layer (RNFL). Important advances in technology for non-invasive imaging of the eye have been made providing quantitative tools to measure structural changes in ONH topography, a crucial step in diagnosing and monitoring glaucoma. 3D spectral domain optical coherence tomography (SD-OCT), an optical imaging technique, has been commonly used to discriminate glaucomatous from healthy subjects...
2014: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Ran Jiang, Liang Xu, Xue Liu, Jian Dong Chen, Jost B Jonas, Ya Xing Wang
PURPOSE: To investigate changes in the optic nerve head morphology after acute intraocular pressure (IOP) elevation during a dark room prone provocative test (DRPPT). DESIGN: Prospective cohort study. PARTICIPANTS: Acute primary angle-closure (APAC) suspects underwent DRPPT. METHODS: Study participants stayed in a dark room for 2 hours with the forehead placed on a desk. At baseline and within 5 minutes after DRPPT, tonometry and enhanced depth imaging by spectral-domain optical coherence tomography (SD OCT) were performed...
April 2015: Ophthalmology
Vishva M Danthurebandara, Glen P Sharpe, Donna M Hutchison, Jonathan Denniss, Marcelo T Nicolela, Allison M McKendrick, Andrew Turpin, Balwantray C Chauhan
PURPOSE: To evaluate the structure-function relationship between disc margin-based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch's membrane opening-based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and visual field sensitivity. METHODS: We examined 151 glaucoma patients with CSLT, SD-OCT, and standard automated perimetry on the same day...
January 2015: Investigative Ophthalmology & Visual Science
Masayuki Hata, Kazuaki Miyamoto, Akio Oishi, Yukiko Makiyama, Norimoto Gotoh, Yugo Kimura, Tadamichi Akagi, Nagahisa Yoshimura
OBJECTIVES: To compare the optic nerve head (ONH) structure between compressive optic neuropathy (CON) and glaucomatous optic neuropathy (GON), and to determine whether selected ONH quantitative parameters effectively discriminate between GON and CON, especially CON cases presenting with a glaucoma-like disc. METHODS: We prospectively assessed 34 patients with CON, 34 age-matched patients with moderate or severe GON, and 34 age-matched healthy control subjects. The quantitative parameters of ONH structure were compared using the Heidelberg Retina Tomograph 2 (HRT2) and Spectralis optical coherence tomography with an enhanced depth imaging method...
2014: PloS One
Stuart K Gardiner, Ruojin Ren, Hongli Yang, Brad Fortune, Claude F Burgoyne, Shaban Demirel
PURPOSE: To test whether the minimum rim area assessed by spectral domain optical coherence tomography (SD-OCT), based on the shortest distance from the Bruch membrane opening (BMO) to the inner limiting membrane, corresponds more closely to retinal nerve fiber layer (RNFL) thickness and visual field mean deviation (MD) than current rim measures in early glaucoma. DESIGN: Prospective cross-sectional study. METHODS: We studied 221 participants with non-endstage glaucoma or high-risk ocular hypertension and performed standard automated perimetry...
March 2014: American Journal of Ophthalmology
Balwantray C Chauhan, Neil O'Leary, Faisal A Almobarak, Alexandre S C Reis, Hongli Yang, Glen P Sharpe, Donna M Hutchison, Marcelo T Nicolela, Claude F Burgoyne
OBJECTIVE: Neuroretinal rim assessment based on the clinical optic disc margin (DM) lacks a sound anatomic basis for 2 reasons: (1) The DM is not reliable as the outer border of rim tissue because of clinically and photographically invisible extensions of Bruch's membrane (BM) inside the DM and (2) nonaccountability of rim tissue orientation in the optic nerve head (ONH). The BM opening-minimum rim width (BMO-MRW) is a parameter that quantifies the rim from its true anatomic outer border, BMO, and accounts for its variable orientation...
March 2013: Ophthalmology
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