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https://www.readbyqxmd.com/read/27825982/comparison-of-bruch-s-membrane-opening-minimum-rim-width-among-those-with-normal-ocular-health-by-race
#1
Lindsay A Rhodes, Carrie E Huisingh, Adam E Quinn, Gerald McGwin, Frank LaRussa, Daniel Box, Cynthia Owsley, Christopher A Girkin
PURPOSE: To examine if racial differences in Bruch's membrane opening-minimum rim width (BMO-MRW) in spectral domain optical coherence tomography (SDOCT) exist, specifically between people of African descent (AD) and European descent (ED) in normal ocular health. DESIGN: Cross-sectional study METHODS: Patients presenting for a comprehensive eye exam at retail-based primary eye clinics were enrolled based on ≥1 of the following at-risk criteria for glaucoma: AD aged ≥ 40 years, ED aged ≥50 years, diabetes, family history of glaucoma, and/or pre-existing diagnosis of glaucoma...
November 5, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27814326/consistency-of-bruch-membrane-opening-detection-as-determined-by-optical-coherence-tomography
#2
Young Hoon Hwang, Min K Kim, Sang I Ahn
PURPOSE: To investigate the consistency of Bruch membrane opening (BMO) detection as determined by Cirrus high-definition optical coherence tomography (OCT). MATERIALS AND METHODS: This study enrolled 106 healthy eyes and 194 glaucomatous eyes who underwent OCT examinations. The location of BMO was evaluated by inspecting 72 cross-sectional optic nerve head (ONH) images (5 degrees intervals for 360 degrees) per eye in which BMO location is automatically detected by the OCT algorithm...
November 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27806111/genome-wide-analysis-of-differentially-expressed-microrna-in-bombyx-mori-infected-with-nucleopolyhedrosis-virus
#3
Ping Wu, Xiaoxu Jiang, Xijie Guo, Long Li, Tao Chen
Bombyx mori nucleopolyhedrosis virus (BmNPV) is a major pathogen that threatens the growth and sustainability of the sericulture industry. Since microRNAs (miRNAs) have been shown to play important roles in host-pathogen interactions, in this study we investigated the effects of BmNPV infection on silkworm microRNAs expression profile. To achieve this, we constructed and deep-sequenced two small RNA libraries generated from BmNPV infected and un-infected larvae. The results revealed that 38 silkworm miRNAs were differentially expressed after BmNPV infection...
2016: PloS One
https://www.readbyqxmd.com/read/27796669/vertical-asymmetry-of-lamina-cribrosa-tilt-angles-using-wide-bandwidth-femtosecond-mode-locked-laser-oct-effect-of-myopia-and-glaucoma
#4
Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Makoto Araie, Shin Yoneya
PURPOSE: Morphological features of the lamina cribrosa (LC) and optic disc may be important in the pathogenesis of glaucoma and myopic neuropathy. We therefore performed a cross-sectional study of patients with glaucoma and myopic neuropathy to evaluate vertical asymmetry of LC tilt angles (LCTAs) from Bruch's membrane opening (BMO). MATERIAL AND METHODS: Forty-six control eyes and 35 primary open-angle glaucoma (POAG) eyes were included. A raster scanning protocol with 300 single B-scans (without averaging) were obtained using optical coherence tomography with a wide-bandwidth, femtosecond mode-locked (ML) laser...
October 28, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27784074/optic-nerve-head-biomechanic-and-iop-changes-before-and-after-the-injection-of-aflibercept-for-neovascular-age-related-macular-degeneration
#5
Gema Rebolleda, Beatriz Puerto, Victoria de Juan, Marta Gómez-Mariscal, Francisco José Muñoz-Negrete, Alfonso Casado
Purpose: We investigated the early effects of intravitreal aflibercept injection (IAI) on optic nerve head (ONH) morphology. Methods: All of the participants underwent applanation tonometry and enhanced depth imaging by spectral-domain optical coherence tomography immediately before injection, and within 5 and 30 minutes after IAI. Changes in the anterior lamina cribrosa surface depth, prelaminar tissue thickness (PTT), optic cup width, optic cup depth, and Bruch's membrane opening (BMO) were assessed...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27763802/a-randomized-double-blind-placebo-controlled-trial-of-schisandra-chinensis-for-menopausal-symptoms
#6
J Y Park, K H Kim
OBJECTIVES: The purpose of this clinical trial was to evaluate the effectiveness of a natural extract from Schisandra chinensis for relief of various menopausal symptoms. METHODS: A randomized, double-blind, placebo-controlled clinical trial was conducted from January 1, 2014 until January 13, 2015. We recruited women between the ages of 40 and 70 years who complained of menopausal symptoms measured by the Kupperman Index (KI). Patients were randomly assigned to treatment with either an extract from Schisandra chinensis (BMO-30) or placebo...
October 20, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27713728/cell-free-spent-media-obtained-from-bifidobacterium-bifidum-and-bifidobacterium-crudilactis-grown-in-media-supplemented-with-3-sialyllactose-modulate-virulence-gene-expression-in-escherichia-coli-o157-h7-and-salmonella-typhimurium
#7
Pauline Bondue, Sébastien Crèvecoeur, François Brose, Georges Daube, Marie-Christine Seghaye, Mansel W Griffiths, Gisèle LaPointe, Véronique Delcenserie
Complex oligosaccharides from human milk (HMO) possess an antimicrobial activity and can promote the growth of bifidobacteria such as Bifidobacterium bifidum and Bifidobacterium longum subsp. infantis. In addition, fermentation of carbohydrates by bifidobacteria can result in the production of metabolites presenting an antivirulence effect on several pathogenic bacteria. Whey is rich in complex bovine milk oligosaccharides (BMO) structurally similar to HMO and B. crudilactis, a species of bovine origin, is able to metabolize some of those complex carbohydrates...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27661851/gaze-evoked-deformations-of-the-peripapillary-retina-in-papilledema-and-ischemic-optic-neuropathy
#8
Patrick A Sibony
Purpose: To examine the effects of horizontal eye movements on the shape of the peripapillary basement membrane layer (ppBM layer) in patients with papilledema, anterior ischemic optic neuropathy (AION) and normal eyes. Methods: Spectral-domain optical coherence tomography (SD-OCT) axial rasters of the optic nerve were used to analyze the shape of the ppBM layer. We compared registered images in two eye positions: 10° to 15° of adduction and 30° to 40° of abduction from 80 patients (45 with papilledema, 15 with AION, and 20 normal eyes)...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27636592/bruch-s-membrane-opening-minimum-rim-width-assessment-with-spectral-domain-optical-coherence-tomography-performs-better-than-confocal-scanning-laser-ophthalmoscopy-in-discriminating-early-glaucoma-patients-from-control-subjects
#9
Anani P Toshev, Julia Lamparter, Norbert Pfeiffer, Esther M Hoffmann
PURPOSE: To compare the diagnostic performance and evaluate diagnostic agreement for early glaucoma detection between a confocal scanning laser ophthalmoscope (CSLO) and a spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Fifty-five eyes of 55 open-angle glaucoma patients and 42 eyes of 42 healthy control subjects were enrolled in this observational, cross-sectional study. All participants underwent comprehensive ophthalmic examination, visual field testing, and optic nerve head and retinal nerve fiber layer imaging by CSLO (HRT3) and SD-OCT (Spectralis OCT)...
September 15, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27620817/differential-expression-of-micrornas-of-litopenaeus-vannamei-in-response-to-different-virulence-wssv-infection
#10
Xinying Sun, Qing-Hui Liu, Bing Yang, Jie Huang
WSSV is one of the most harmful pathogeny in the pacific white shrimp, and genetic variations caused the strains of different virulence. MicroRNAs (miRNAs) involved in the regulation of virus defense. To understand the different virulence of WSSV on miRNA expression in Litopeneaus vannamei, the deep sequencing was performed to compare two small RNA libraries prepared from hepatopancreas of Litopeneaus vannamei infected with normal-virulence or low-virulence WSSV. Approximately 29,398,623 raw reads from normal-virulence library and 35,291,803 raw reads from low-virulence library were obtained...
September 13, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27583829/peripapillary-pachychoroid-in-nonarteritic-anterior-ischemic-optic-neuropathy
#11
Lina Nagia, Carrie Huisingh, John Johnstone, Lanning B Kline, Mark Clark, Michael J A Girard, Jean Martial Mari, Christopher A Girkin
PURPOSE: This study examined the peripapillary choroidal thickness (PCT) in nonarteritic ischemic optic neuropathy (NAION) in comparison to contralateral eyes and normal eyes. METHODS: We used enhanced depth imaging spectral-domain optical coherence tomography to image the optic nerve head of 20 NAION, 10 contralateral eyes, and 102 normal eyes. Following compensation, the scans were manually delineated to identify relevant surfaces including Bruch's membrane opening (BMO), Bruch's membrane, and anterior sclera...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27564522/experimental-glaucoma-causes-optic-nerve-head-neural-rim-tissue-compression-a-potentially-important-mechanism-of-axon-injury
#12
Brad Fortune, Juan Reynaud, Christy Hardin, Lin Wang, Ian A Sigal, Claude F Burgoyne
PURPOSE: We tested the hypothesis that experimental glaucoma (EG) results in greater thinning of the optic nerve head (ONH) neural rim tissue than the peripapillary retinal nerve fiber layer (RNFL) tissue. METHODS: Longitudinal spectral-domain optical coherence tomography (SDOCT) imaging of the ONH and peripapillary RNFL was performed every other week under manometric IOP control (10 mm Hg) in 51 nonhuman primates (NHP) during baseline and after induction of unilateral EG...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27548890/glaucoma-diagnostic-ability-of-the-new-circumpapillary-retinal-nerve-fiber-layer-thickness-analysis-based-on-bruch-s-membrane-opening
#13
Eun Ji Lee, Kyoung Min Lee, Hyunjoong Kim, Tae-Woo Kim
PURPOSE: To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic disc. METHODS: In 75 eyes with primary open-angle glaucoma (POAG) and 71 healthy control eyes, circumpapillary RNFL thickness was measured with SD-OCT, first by centering the scan circle on the optic disc (RNFLDi), and then on the BMO (RNFLBMO)...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27547890/comparison-of-bruch-s-membrane-opening-minimum-rim-width-and-peripapillary-retinal-nerve-fiber-layer-thickness-in-early-glaucoma-assessment
#14
Jonas M D Gmeiner, Wolfgang A Schrems, Christian Y Mardin, Robert Laemmer, Friedrich E Kruse, Laura M Schrems-Hoesl
PURPOSE: To compare the diagnostic value of Bruch's membrane opening minimum rim width (BMO-MRW) and retinal nerve fiber layer thickness (RNFLT) in patients with ocular hypertension, preperimetric, and perimetric glaucoma. METHODS: One hundred eighty-one eyes consisting of 40 healthy controls, 41 ocular hypertensive subjects, 50 subjects with preperimetric glaucoma and 50 with perimetric glaucoma were included. One randomly selected eye was included. All patients underwent slit-lamp examination, funduscopy, achromatic perimetry, and 24-hour IOP profile...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27521172/optic-nerve-head-development-in-healthy-infants-and-children-using-handheld-spectral-domain-optical-coherence-tomography
#15
Aarti Patel, Ravi Purohit, Helena Lee, Viral Sheth, Gail Maconachie, Eleni Papageorgiou, Rebecca J McLean, Irene Gottlob, Frank A Proudlock
PURPOSE: To determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective cross-sectional study. PARTICIPANTS: Three hundred fifty-two children aged between 1 day and 13 years. METHODS: All participants were imaged using handheld SD OCT without sedation during a single scan session...
October 2016: Ophthalmology
https://www.readbyqxmd.com/read/27507325/incorporation-of-gradient-vector-flow-field-in-a-multimodal-graph-theoretic-approach-for-segmenting-the-internal-limiting-membrane-from-glaucomatous-optic-nerve-head-centered-sd-oct-volumes
#16
Mohammad Saleh Miri, Victor A Robles, Michael D Abràmoff, Young H Kwon, Mona K Garvin
The internal limiting membrane (ILM) separates the retina and optic nerve head (ONH) from the vitreous. In the optical coherence tomography volumes of glaucoma patients, while current approaches for the segmentation of the ILM in the peripapillary and macular regions are considered robust, current approaches commonly produce ILM segmentation errors at the ONH due to the presence of blood vessels and/or characteristic glaucomatous deep cupping. Because a precise segmentation of the ILM surface at the ONH is required for computing several newer structural measurements including Bruch's membrane opening-minimum rim width (BMO-MRW) and cup volume, in this study, we propose a multimodal multiresolution graph-based method to precisely segment the ILM surface within ONH-centered spectral-domain optical coherence tomography (SD-OCT) volumes...
July 25, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/27479577/-bruch-s-membrane-opening-in-oct-in-correlation-with-corneal-correction-a-pilot-study
#17
J Luebke, D Böhringer, T Reinhard, A Anton
: Background: The measurement by optical coherence tomography (OCT) of the Bruch membrane opening (BMO) and the thinnest retinal fiber nerve layer in relation to it (BMO-MRW) has been performed in clinical routine since 2014. To compensate for astigmatism, or increased or decreased corneal power, a correction is performed through the mean K-value of the measured eye. The aim of this study was to measure the value of this correction and its influence on the measurement results. Methods: The sectors of BMO-MRW and BMO values of the five right eyes of five healthy patients were measured five times each with Heidelberg Spectralis OCT...
August 1, 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27466818/prediction-and-validation-of-transcription-factors-modulating-the-expression-of-sestrin3-gene-using-an-integrated-computational-and-experimental-approach
#18
Rajneesh Srivastava, Yang Zhang, Xiwen Xiong, Xiaoning Zhang, Xiaoyan Pan, X Charlie Dong, Suthat Liangpunsakul, Sarath Chandra Janga
SESN3 has been implicated in multiple biological processes including protection against oxidative stress, regulation of glucose and lipid metabolism. However, little is known about the factors and mechanisms controlling its gene expression at the transcriptional level. We performed in silico phylogenetic footprinting analysis of 5 kb upstream regions of a diverse set of human SESN3 orthologs for the identification of high confidence conserved binding motifs (BMo). We further analyzed the predicted BMo by a motif comparison tool to identify the TFs likely to bind these discovered motifs...
2016: PloS One
https://www.readbyqxmd.com/read/27458582/fusion-to-hydrophobin-hfbi-improves-the-catalytic-performance-of-a-cytochrome-p450-system
#19
Sebastian Schulz, Dominik Schumacher, Daniel Raszkowski, Marco Girhard, Vlada B Urlacher
Cytochrome P450 monooxygenases (P450) are heme-containing enzymes that oxidize a broad range of substrates in the presence of molecular oxygen and NAD(P)H. For their activity, most P450s rely on one or two redox proteins responsible for the transfer of electrons from the cofactor NAD(P)H to the heme. One of the challenges when using P450s in vitro, especially when non-physiological redox proteins are applied, is the inefficient transfer of electrons between the individual proteins resulting in non-productive consumption of NAD(P)H - referred to as uncoupling...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27436783/the-use-of-bruch-s-membrane-opening-based-optical-coherence-tomography-of-the-optic-nerve-head-for-glaucoma-detection-in-microdiscs
#20
Philip Enders, Friederike Schaub, Werner Adler, Roman Nikoluk, Manuel M Hermann, Ludwig M Heindl
PURPOSE: To assess the performance of Bruch's membrane opening (BMO)-based spectral domain optical coherence tomography (SD-OCT) of the optic nerve head for glaucoma detection in microdiscs in comparison with confocal scanning laser tomography (CSLT). DESIGN: Retrospective cohort study. METHODS: 82 eyes of 82 patients with disc size <1.63 mm(2) underwent SD-OCT and CSLT measurements, visual field testing and clinical examination. BMO-based minimal rim width (BMO-MRW), retinal nerve fibre layer thickness (RNFLT) in SD-OCT and rim area measured in CSLT were compared and correlated with visual field defects...
July 19, 2016: British Journal of Ophthalmology
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