Yuchen Li, Sisi Luan, Cairong Ruan, Weihao Li, Xinyu Zhang, Zijing Ran, Wenkai Bi, Yuelin Tong, Ling Gao, Jiajun Zhao, Yuan Li, Zhao He
Subclinical hyperthyroidism is defined biochemically as a low or undetectable thyroid-stimulating hormone (TSH) with normal thyroid hormone levels. Low TSHR signaling is considered to associate with cognitive impairment. However, the underlying molecular mechanism by which TSHR signaling modulates memory is poorly understood. In this study, we found that Tshr-deficient in the hippocampal neurons impairs the learning and memory abilities of mice, accompanying by a decline in the number of newborn neurons. Notably, Tshr ablation in the hippocampus decreases the expression of Wnt5a, thereby inactivating the β-catenin signaling pathway to reduce the neurogenesis...
February 28, 2024: Biochemical and Biophysical Research Communications