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https://www.readbyqxmd.com/read/29661984/unrepaired-dna-damage-in-macrophages-causes-elevation-of-particulate-matter-induced-airway-inflammatory-response
#1
Man Luo, Zhengqiang Bao, Feng Xu, Xiaohui Wang, Fei Li, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen
The inflammatory cascade can be initiated with the recognition of damaged DNA. Macrophages play an essential role in particulate matter (PM)-induced airway inflammation. In this study, we aim to explore the PM induced DNA damage response of macrophages and its function in airway inflammation. The DNA damage response and inflammatory response were assessed using bone marrow-derived macrophages following PM treatment and mouse model instilled intratracheally with PM. We found that PM induced significant DNA damage both in vitro and in vivo and simultaneously triggered a rapid DNA damage response, represented by nuclear RPA, 53BP1 and γH2AX foci formation...
April 14, 2018: Aging
https://www.readbyqxmd.com/read/29659020/surgical-management-of-chronic-otitis-secondary-to-craniomandibular-osteopathy-in-three-west-highland-white-terriers
#2
L Beever, F Swinbourne, S L Priestnall, G Ter Haar, D J Brockman
Three West Highland white terriers were presented for investigation of left-sided para-aural abscessation. CT revealed chronic otitis media with extensive osseous proliferation surrounding the horizontal and vertical ear canals contiguous with the expanded temporal bone, consistent with a unilateral variant of craniomandibular osteopathy. A left total ear canal ablation with lateral bulla osteotomy was performed in all dogs. An ultrasonic bone curette (Sonopet; Stryker) proved useful when removing the osseous proliferation in two dogs...
April 16, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29651974/preparation-and-dosimetry-evaluation-of-a-carrier-free-90y-labeled-dotmp-as-a-promising-agent-for-bone-marrow-ablation
#3
Nafise Salek, Sara Vosoghi, Simindokht Shirvani Arani, Ali Bahrami Samani, Mohsen Mehrabi, Mohammad Ghannadi Maraghe
BACKGROUND AND OBJECTIVE: Skeletal uptake of 90Y-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonate (DOTMP) is used to deliver high doses of this radiopharmaceutical to the bone marrow. METHODS: In this research, carrier-free (c.f.) 90Y was obtained from an electrochemical 90Sr/90Y generator. The c.f. 90Y was mixed with 300 µL of DOTMP (20 mg/mL) and incubated under stirring conditions at room temperature for 45 min. RESULTS: The [90Y]Y-DOTMP that was obtained under optimized reaction conditions had the high radiochemical purities (>98%)...
April 12, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29651762/experience-of-neuroprotective-air-injection-during-radiofrequency-ablation-rfa-of-spinal-osteoid-osteoma
#4
Alessandro Vidoni, Melvin Grainger, Steven James
PURPOSE: To assess the usefulness of epidural air injection during the RFA treatment of spinal osteoid osteoma. METHODS: A retrospective review of 17 patients who underwent RFA for spinal osteoid osteoma between September 2006 and May 2017 was performed. All the procedures were performed by a single radiologist. We reviewed the perioperative CT studies to assess the distribution of air relative to the osteoid osteoma. The clinical outcome of each patient group was evaluated during routine follow-up...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29651367/-lazarus-response-to-olaparib-in-a-virtually-chemonaive-breast-cancer-patient-carrying-gross-brca2-gene-deletion
#5
Vladimir M Moiseyenko, Vyacheslav A Chubenko, Fedor V Moiseyenko, Lyudmila A Zagorskaya, Yuliya A Zaytseva, Nataliya E Gesha, Evgeny N Zykov, Valeriya I Ni, Elena V Preobrazhenskaya, Anna P Sokolenko, Evgeny N Imyanitov
This report describes an estrogen receptor-positive breast cancer patient, who relapsed at two and a half years after the completion of adjuvant chemotherapy while being on the aromatase inhibition. Based on the clinical evidence for potential sensitivity of the tumor to hormone ablation, everolimus was added to continuing exemestane treatment. Oral chemotherapy was administered at further disease progression, however, it lasted only for 10 days due to rapidly deteriorating condition of the patient. BRCA test was performed just before the failure of endocrine therapy and revealed a gross deletion within BRCA2 gene...
February 4, 2018: Curēus
https://www.readbyqxmd.com/read/29643986/ajuba-receptor-mediates-the-internalization-of-tumor-secreted-grp78-into-macrophages-through-different-endocytosis-pathways
#6
Xiaoqin La, Lichao Zhang, Hanqing Li, Zhuoyu Li, Guisheng Song, Peng Yang, Yufei Yang
Glucose-regulated protein 78 (GRP78), an ER chaperone, is overexpressed in cancer cells. Solid tumor cells can secrete GRP78 that can promote tumor angiogenesis, differentiation of bone marrow-derived mesenchymal stem cells, tumor cell proliferation and polarization of tumor-associated macrophages. However, the mechanism by which GRP78 functions as a tumor promoter either by staying on the membrane to stimulate intracellular signals or directly entering into cytosolic remains unknown. Here, we reported that an endotoxin-free His-GRP78 protein was purified in vitro that simulates original secreted GRP78...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29643667/role-of-preablative-stimulated-thyroglobulin-in-prediction-of-nodal-and-distant-metastasis-on-iodine-whole-body-scan
#7
Meghana Prabhu, Sanju Samson, Avinash Reddy, Sunil Hejaji Venkataramanarao, Naveen Hedne Chandrasekhar, Vijay Pillai, Vivek Shetty, Moni Abraham Koriokose, Bushan Vaidhya, Subramanian Kannan
Background: Preablative stimulated thyroglobulin (ps-Tg) is an important investigation in the follow-up of patients with Differentiated thyroid cancer(DTC) after surgery. Levels of ps-Tg >2-10 ng/ml have been suggested to predict metastasis to cervical and extracervical sites. There is still debate on the need for routine iodine whole-body scan (131 I WBS) in the management of low-to-intermediate-risk DTC patients. Objective: We analyzed our data of patients with DTC who underwent total thyroidectomy to discuss the predictability of ps-Tg on metastatic disease on the 131 I WBS...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29626053/insulin-like-growth-factors-actions-on-the-skeleton
#8
Shoshana Yakar, Haim Werner, Cliff Rosen
The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins), insulin-like growth factor (IGF)-I and -II, has elicited an enormous interest primarily amongst endocrinologists who study growth and metabolism. The advancement of molecular endocrinology over the past four decades enables investigators to re-examine and refine the established somatomedin hypothesis. Specifically, gene deletions, transgene overexpression, or more recently, cell-specific gene-ablations, have enabled investigators to study the effects of the Igf-I and Igf-II genes in temporal and spatial manners...
April 6, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29621929/laser-synthesized-nanocrystalline-ferroelectric-bioactive-batio-3-pt-fs-for-bone-implants
#9
Miroslav Jelínek, Elena Buixaderas, Jan Drahokoupil, Tomáš Kocourek, Jan Remsa, Přemysl Vaněk, Marta Vandrovcová, Martina Doubková, Lucie Bačáková
The goal of our study is to design BaTiO3 ferroelectric layers that will cover metal implants and provide improved osseointegration. We synthesized ferroelectric BaTiO3 layers on Pt/fused silica substrates, and we studied their physical and bio-properties. BaTiO3 and Pt layers were prepared using KrF excimer laser ablation at substrate temperature Ts in the range from 200°C to 750°C in vacuum or under oxygen pressure of 10 Pa, 15 Pa, and 20 Pa. The BaTiO3 /Pt and Pt layers adhered well to the substrates. BaTiO3 films of crystallite size 60-140 nm were fabricated...
January 1, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29617179/sclerostin-and-dkk1-inhibition-preserves-and-augments-alveolar-bone-volume-and-architecture-in-rats-with-alveolar-bone-loss
#10
M Liu, P Kurimoto, J Zhang, Q T Niu, M Stolina, P C Dechow, J Q Feng, J Hesterman, M D Silva, M S Ominsky, W G Richards, H Ke, P J Kostenuik
Alveolar bone is a mechanosensitive tissue that provides structural support for teeth. Alveolar bone loss is common with aging, menopause, tooth loss, and periodontitis and can lead to additional tooth loss, reduced denture fixation, and challenges in placing dental implants. The current studies suggest that sclerostin and DKK1, which are established osteocyte-derived inhibitors of bone formation, contribute to alveolar bone loss associated with estrogen ablation and edentulism in rats. Estrogen-deficient ovariectomized rats showed significant mandibular bone loss that was reversed by systemic administration of sclerostin antibody (SAB) alone and in combination with DKK1 antibody (DAB)...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29574182/tmem30a-plays-critical-roles-in-ensuring-the-survival-of-hematopoietic-cells-and-leukemia-cells-in-mice
#11
Ning Li, Yeming Yang, Cailing Liang, Qiang Qiu, Cong Pan, Mengyuan Li, Shengyong Yang, Lijuan Chen, Xianjun Zhu, Yiguo Hu
The fundamental structure of eukaryotic cell plasma membrane is the phospholipid bilayer, which contains four major phospholipids. These phospholipids are asymmetrically distributed between the outer and inner leaflets. P4-ATPase flippase complexes play essential roles in ensuring this asymmetry. Here we showed that conditional deletion of Tmem30a, the beta subunit of P4-ATPase flippase complex, caused pancytopenia in mice. Tmem30a deficiency resulted in depletion of lineage-committed blood cells in the peripheral blood, spleen, and bone marrow...
March 21, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29572380/the-identification-of-fibrosis-driving-myofibroblast-precursors-reveals-new-therapeutic-avenues-in-myelofibrosis
#12
Rafael Kramann, Rebekka K Schneider
Myofibroblasts are fibrosis-driving cells and well characterized in solid organ fibrosis but their role and cellular origin in bone marrow fibrosis remained obscure. Recent work has demonstrated that Gli1+ and LepR+ mesenchymal stromal cells (MSC) are progenitors of fibrosis-causing myofibroblasts in the bone marrow. Genetic ablation of Gli1+ MSC or pharmacological targeting Hedghog-Gli signaling ameliorated fibrosis in mouse models of myelofibrosis (MF). Moreover, pharmacologic or genetic intervention in platelet-derived growth factor receptor alpha ( Pdgfra ) signaling in Lepr + stromal cells suppressed their expansion and ameliorated MF...
March 23, 2018: Blood
https://www.readbyqxmd.com/read/29570794/understanding-deregulated-cellular-and-molecular-dynamics-in-the-hematopoietic-stem-cell-niche-to-develop-novel-therapeutics-in-bone-marrow-fibrosis
#13
REVIEW
Hélène F E Gleitz, Rafael Kramann, Rebekka K Schneider
Bone marrow fibrosis is the continuous replacement of blood forming cells in the bone marrow by excessive scar tissue, leading to failure of the body to produce blood cells and ultimately to death. Myofibroblasts are fibrosis-driving cells and well characterized in solid organ fibrosis but their role and cellular origin in bone marrow fibrosis has remained obscure. Recent work has demonstrated that Gli1+ and Leptin Receptor+ mesenchymal stromal cells are progenitors of fibrosis-causing myofibroblasts in the bone marrow...
March 23, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29570431/g-protein-coupled-receptor-kinase-2-deficient-mice-are-protected-from-dextran-sodium-sulfate-induced-acute-colitis
#14
Michael D Steury, Ho Jun Kang, Taehyung Lee, Peter C Lucas, Laura R McCabe, Narayanan Parameswaran
G-protein coupled receptor kinase 2 (GRK2) is a serine/threonine kinase and plays a key role in different disease processes. Previously, we showed that GRK2 knockdown enhances wound healing in colonic epithelial cells. Therefore, we hypothesized that ablation of GRK2 would protect mice from dextran sodium sulfate (DSS)-induced acute colitis. To test this, we administered DSS to wild-type (GRK2+/+ ) and GRK2 heterozygous (GRK+/- ) mice in their drinking water for 7 days. As predicted, GRK2+/- mice were protected from colitis as demonstrated by decreased weight loss (20% loss in GRK2+/+ vs 11% loss in GRK2+/- ); lower disease activity index (GRK2+/+ 9...
March 23, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29567631/interventional-radiology-role-in-the-treatment-of-sarcomas
#15
REVIEW
Thierry de Baere, Lambros Tselikas, Guillaume Gravel, Antoine Hakime, Frederic Deschamps, Charles Honoré, Olivier Mir, Axel Lecesne
In bone and soft tissue sarcomas (STS), surgery was to the only local curative treatment, but recently, radiation therapy and interventional radiology has evolved to potentially curative treatment, namely in small size tumours. Indication for local treatment in STS needs validation in multidisciplinary team. Most will agree on local treatment for single metastatic location in a well-controlled disease and for no local treatment in a rapidly evolving multi-metastatic disease. The challenge is in patients who are in between, for whom benefit of disease control on overall survival should be evaluated...
March 19, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29564836/a-practical-guide-for-planning-pelvic-bone-percutaneous-interventions-biopsy-tumour-ablation-and-cementoplasty
#16
REVIEW
Marta Oñate Miranda, Thomas P Moser
Percutaneous approaches for pelvic bone procedures (bone biopsies, tumour ablation and cementoplasty) are multiple and less well systematised than for the spine or extremities. Among the different imaging techniques that can be used for guidance, computed tomography (CT) scan is the modality of choice because of the complex pelvic anatomy. In specific cases, such as cementoplasty where real-time evaluation is a determinant, a combination of CT and fluoroscopy is highly recommended. The objective of this article is to propose a systematic approach for image-guided pelvic bone procedures, as well as to provide some technical tips...
March 21, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29558966/a-prospective-phase-i-dose-escalation-trial-of-stereotactic-ablative-radiotherapy-sabr-as-an-alternative-to-cytoreductive-nephrectomy-for-inoperable-patients-with-metastatic-renal-cell-carcinoma
#17
Rohann J M Correa, Belal Ahmad, Andrew Warner, Craig Johnson, Mary J MacKenzie, Stephen E Pautler, Glenn S Bauman, George B Rodrigues, Alexander V Louie
BACKGROUND: Cytoreductive nephrectomy is thought to improve survival in metastatic renal cell carcinoma (mRCC). As many patients are ineligible for major surgery, we hypothesized that SABR could be a safe alternative. METHODS: In this dose-escalation trial, inoperable mRCC patients underwent SABR targeting the entire affected kidney. Toxicity (CTCAE v3.0), quality of life (QoL), renal function, and tumour response (RECIST v1.0) were assessed. RESULTS: Twelve patients of mostly intermediate (67%) or poor (25%) International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) prognostic class, median KPS of 70%, and median tumour size of 8...
March 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29556576/external-beam-radiation-therapy-for-advanced-unresectable-malignant-paraganglioma-and-pheochromocytoma
#18
William Breen, Irina Bancos, William F Young, Keith C Bible, Nadia N Laack, Robert L Foote, Christopher L Hallemeier
Purpose/Objectives: To evaluate the role of external beam radiation therapy (EBRT) for treatment of malignant paraganglioma (PGL) and pheochromocytoma (PCC). Methods and materials: A retrospective review was performed of all patients with malignant PGL/PCC treated with EBRT at our institution between 1973 and 2015. Local control (LC) per treated lesion and overall survival were estimated using the Kaplan-Meier method. Toxicities were scored using the Common Toxicity Criteria for Adverse Events (AE), version 4...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556231/c-reactive-protein-impairs-dendritic-cell-development-maturation-and-function-implications-for-peripheral-tolerance
#19
Rachel V Jimenez, Tyler T Wright, Nicholas R Jones, Jianming Wu, Andrew W Gibson, Alexander J Szalai
C-reactive protein (CRP) is the prototypical acute phase reactant, increasing in blood concentration rapidly and several-fold in response to inflammation. Recent evidence indicates that CRP has an important physiological role even at low, baseline levels, or in the absence of overt inflammation. For example, we have shown that human CRP inhibits the progression of experimental autoimmune encephalomyelitis (EAE) in CRP transgenic mice by shifting CD4+ T cells away from the TH 1 and toward the TH 2 subset. Notably, this action required the inhibitory Fcγ receptor IIB (FcγRIIB), but did not require high levels of human CRP...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29541786/osteoid-osteoma-of-the-scaphoid-bone-associated-with-flexor-carpi-radialis-calcific-tendinitis-and-treated-with-ct-guided-rf-ablation
#20
Michalis Michaelides, Elena Drakonaki, Elia Petridou, Maria Pantziara, Cleanthis Ioannides
Osteoid osteomas of the wrist are relatively rare and the diagnosis is challenging due to atypical clinical features. We describe a case of an osteoid osteoma of the scaphoid bone associated with calcific tendinitis of the adjacent flexor carpi radialis tendon and periarticular soft tissue calcifications in a 21-year-old man presenting with radial-sided wrist pain. The lesion was successfully treated with CT-guided RF ablation. To our knowledge, this is the first description of an osteoid osteoma of the wrist associated with calcific tendinitis and periarthritis...
March 14, 2018: Skeletal Radiology
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