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https://www.readbyqxmd.com/read/28423221/facial-asymmetry-in-head-and-neck-rhabdomyosarcoma-survivors
#1
Reineke A Schoot, Marinka L F Hol, Johannes H M Merks, Michael Suttie, Olga Slater, Marinde van Lennep, Saskia M J Hopman, David Dunaway, Jonathan Syme-Grant, Ludi E Smeele, Koos H Zwinderman, Huib N Caron, Peter Hammond
INTRODUCTION: Radiotherapy is essential for achieving and maintaining local control in head and neck rhabdomyosarcoma (HNRMS) patients. However, radiotherapy may cause outgrowth disturbances of facial bone and soft tissue, resulting in facial asymmetry. The aim of this study was to develop a method to visualize and measure facial asymmetry in HNRMS survivors using three-dimensional (3D) imaging techniques. METHODS: Facial deformity was evaluated in a multidisciplinary clinical assessment of 75 HNRMS survivors, treated with external beam radiotherapy (EBRT, n = 26) or Ablative surgery, MOulage brachytherapy, and REconstruction (AMORE, n = 49)...
April 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28417678/changes-in-peripheral-blood-t-cell-balance-after-percutaneous-tumor-ablation
#2
Haruyuki Takaki, Naoko Imai, Contessa T Thomas, Koichiro Yamakado, Yarmohammadi Hooman, Etay Ziv, Govindarajan Srimathveeravalli, Constantinos T Sofocleous, Stephen B Solomon, Joseph P Erinjeri
PURPOSE: To evaluate the changes in T-cell balance in peripheral blood following percutaneous tumor ablation. MATERIAL AND METHODS: Patients underwent thermal ablation including radiofrequency (n = 9) and microwave ablation (n = 5), or cryoablation (n = 5). Target tumors were located in the lung (n = 7), soft tissue (n = 5), liver (n = 4), and bone (n = 3). Patient peripheral blood samples were collected before and within 14 days after ablation...
April 18, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28416360/primary-hepatic-angiosarcoma-and-liver-transplantation-radiological-surgical-histological-findings-and-clinical-outcome
#3
M Tran Minh, A Mazzola, F Perdigao, F Charlotte, G Rousseau, F Conti
Angiosarcoma is a rare type of soft tissue sarcoma that accounts for less than 1% of all sarcomas and only 2% of all primary hepatic tumours. Thorotrast, arsenic, and vinyl chloride monomer are frequently listed as occupational exposure risks. The estimated latency is long (10-40 years) in occupational cases and very long (60 years or more) in non-occupational cases. The symptoms and CT-scan appearance of hepatic angiosarcoma (HAS) are non-specific. We present a case of a 65-year-old Caucasian male with history of cryptogenic cirrhosis, low alpha-foetoprotein levels and a single, 4-cm nodule of potential atypical hepatocellular carcinoma (no washout at MRI and CT-scan) in segment VIII...
April 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28413736/targeted-intraspinal-radiofrequency-ablation-for-lumbar-spinal-stenosis
#4
Robert E Jacobson, Michelle Granville, Jesse Hatgis DO
INTRODUCTION: By using a combination of magnetic resonance imaging (MRI) and computed tomography (CT) of the lumbar spine, it is possible to distinguish between spinal stenosis caused by bone compression and specific soft tissue epidural intraspinal lesions that cause localized spinal canal stenosis and neural compression. Examples include facet cysts and yellow ligament hypertrophy. Many of these patients are elderly with medical comorbidities that make open surgery problematic. MATERIALS & METHODS: This is a study of patients with predominantly soft tissue stenosis being treated with targeted intraspinal radiofrequency (RF) heat ablation...
March 10, 2017: Curēus
https://www.readbyqxmd.com/read/28412561/metastatic-human-breast-cancer-to-the-spine-produces-mechanical-hyperalgesia-and-gait-deficits-in-rodents
#5
Rachel Sarabia-Estrada, Alejandro Ruiz-Valls, Hugo Guerrero-Cazares, Ana M Ampuero, Ismael Jimenez-Estrada, Samantha De Silva, Lydia J Bernhardt, C Rory Goodwin, A Karim Ahmed, Yuxin Li, Neil A Phillips, Ziya L Gokaslan, Alfredo Quiñones-Hinojosa, Daniel M Sciubba
BACKGROUND CONTEXT: Metastases to the spine are a common source of severe pain in cancer patients. The secondary effects of spinal metastases include pain, bone fractures, hypercalcemia, and neurological deficits. As the disease progresses, pain severity can increase until it becomes refractory to medical treatments and leads to a decreased quality of life for patients. A key obstacle in the study of pain-induced spinal cancer is the lack of reliable and reproducible spine cancer animal models...
April 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28405523/histidine-decarboxylase-hdc-expressing-granulocytic-myeloid-cells-induce-and-recruit-foxp3-regulatory-t-cells-in-murine-colon-cancer
#6
Xiaowei Chen, Yoshihiro Takemoto, Huan Deng, Moritz Middelhoff, Richard A Friedman, Timothy H Chu, Michael J Churchill, Yan Ma, Karan K Nagar, Yagnesh H Tailor, Siddhartha Mukherjee, Timothy C Wang
The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus facilitating tumor escape from immunoediting. We have identified a genetically and functionally distinct subset of dynamic bone marrow myeloid cells that are characterized by histidine decarboxylase (HDC) expression. Lineage tracing in Hdc-CreERT2;R26-LSL-tdTomato mice revealed that in homeostasis, there is a strong bias by HDC(+) myeloid cells toward the CD11b(+)Ly6G(hi) granulocytic lineage, which was accelerated during azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colonic carcinogenesis...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28401265/dynamic-contrast-enhanced-mr-imaging-in-osteoid-osteoma-relationships-with-clinical-and-ct-characteristics
#7
P Pottecher, E Sibileau, S Aho, B Hamze, C Parlier, J D Laredo, V Bousson
OBJECTIVE: To correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features to clinical and computed tomography (CT) morphological features of osteoid osteoma (OO). MATERIALS AND METHODS: Our institutional review board approved this retrospective study, waiving the need for informed consent. We included the 102 patients treated with interstitial laser ablation for histologically documented OO at our institution in 2008-2013. DCE-MRI variables were the time-enhancement pattern and rising slope (Sloperise) and CT variables were the bone and segment involved (OObone and OOsegment, respectively), OO location relative to the native cortex (OOcortex), nidus surface area, vessel sign, and largest neighboring-vessel diameter (Dmaxvessel)...
April 11, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28394852/peripheral-inflammatory-pain-sensitisation-is-independent-of-mast-cell-activation-in-male-mice
#8
Douglas M Lopes, Franziska Denk, Kim I Chisholm, Tesha Suddason, Camille Durrieux, Matthew Thakur, Clive Gentry, Stephen B McMahon
The immune and sensory systems are known for their close proximity and interaction. Indeed, in a variety of pain states a myriad of different immune cells are activated and recruited, playing a key role in neuronal sensitisation. During inflammatory pain it is thought that mast cells (MC) are one of the immune cell types involved in this process, but so far the evidence outlining their direct effect on neuronal cells remains unclear. To clarify whether MC are involved in inflammatory pain states, we used a transgenic mouse line (Mctp5CreiDTR) in which MC could be depleted in an inducible manner by administration of diphtheria toxin...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28391383/percutaneous-radiofrequency-ablation-for-spinal-osteoid-osteoma-and-osteoblastoma
#9
Ben Wang, Song Bo Han, Liang Jiang, Hui Shu Yuan, Chen Liu, Bin Zhu, Zhong Jun Liu, Xiao Guang Liu
PURPOSES: We sought to verify the efficacy and safety of RFA in spinal OO and osteoblastomas (OB) (Enneking Stage 2, S2). METHODS: We retrospectively reviewed patients treated in our hospital. Surgical resection was indicated for Enneking Stage 3 OB. RFA indications for spinal OO and OB (S2) were no neurological deficits, complete bone cortex around the lesion on computed tomography (CT), and cerebrospinal fluid between a lesion and the spinal cord/nerve root on magnetic resonance imaging...
April 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28384378/functional-outcome-after-surgery-in-patients-with-bone-sarcoma-around-the-knee-results-from-a-long-term-prospective-study
#10
Janneke C van Egmond-van Dam, W Peter Bekkering, Jos A M Bramer, Auke Beishuizen, Marta Fiocco, P D Sander Dijkstra
BACKGROUND AND OBJECTIVES: In a previous conducted study functional outcome of young patients with bone sarcoma located around the knee was longitudinally evaluated during the first 2 years postoperatively. Functional outcome improved significantly over the first 2 years. The purpose of this descriptive study was to evaluate the functional outcome of these patients at long-term follow-up of 7 years. METHODS: Functional outcome was assessed with the TESS, MSTS, Baecke questionnaire, and three functional performance tests: time up and down stairs (TUDS), various walking activities (VWA), and the 6-min walking test (6MWT)...
April 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28384223/evaluation-of-accuracy-and-precision-of-ct-guidance-in-radiofrequency-ablation-for-osteoid-osteoma-in-86-patients
#11
H Nijland, J G Gerbers, S K Bulstra, J Overbosch, M Stevens, P C Jutte
BACKGROUND AND PURPOSE: Osteoid osteoma is a benign skeletal tumour that accounts for 2-3% of all bone tumours. The male-to-female ratio is around 4:1 and it predominates in children and young adults. The most common symptom is pain, frequently at night-time. Historically the main form of treatment has been surgical excision. With the development of Radiofrequency Ablation (RFA) there is a percutaneus alternative. Success rates of RFA are lower but the main advantage is the minimal invasive character of the therapy and the low complication rate...
2017: PloS One
https://www.readbyqxmd.com/read/28382965/p38%C3%AE-mapk-regulates-proliferation-and-differentiation-of-osteoclast-progenitors-and-bone-remodeling-in-an-aging-dependent-manner
#12
Qian Cong, Hao Jia, Ping Li, Shoutao Qiu, James Yeh, Yibin Wang, Zhen-Lin Zhang, Junping Ao, Baojie Li, Huijuan Liu
Bone mass is determined by the balance between bone formation, carried out by mesenchymal stem cell-derived osteoblasts, and bone resorption, carried out by monocyte-derived osteoclasts. Here we investigated the potential roles of p38 MAPKs, which are activated by growth factors and cytokines including RANKL and BMPs, in osteoclastogenesis and bone resorption by ablating p38α MAPK in LysM+monocytes. p38α deficiency promoted monocyte proliferation but regulated monocyte osteoclastic differentiation in a cell-density dependent manner, with proliferating p38α(-/-) cultures showing increased differentiation...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28375987/hematopoietic-stem-cells-under-pressure
#13
Miguel Ganuza, Shannon McKinney-Freeman
PURPOSE OF REVIEW: Hematopoietic stem cells (HSCs) and progenitors are tasked with maintaining hematopoietic homeostasis in the face of numerous insults and challenges, including infection, inflammation, and exsanguination. HSCs possess the remarkable ability to reconstitute the entire hematopoietic system of an organism whose own hematopoietic system has been ablated. This ability is exploited routinely in the clinic via HSC transplantation (HSCT). Here, we focus on the physiological and molecular bottlenecks overcome by HSCs during transplantation...
April 1, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28370465/pharmacologic-calcitriol-inhibits-osteoclast-lineage-commitment-via-the-bmp-smad1-i%C3%AE%C2%BAb-nf-%C3%AE%C2%BAb-pathway
#14
Anna Li, Qian Cong, Xuechun Xia, Wai Fook Leong, James Yeh, Dengshun Miao, Yuji Mishina, Huijuan Liu, Baojie Li
Vitamin D is involved in a range of physiological processes and its active form and analogs have been used to treat diseases such as osteoporosis. Yet how vitamin D executes its function remains unsolved. Here we show that the active form of vitamin D calcitriol increases the peak bone mass in mice by inhibiting osteoclastogenesis and bone resorption. Although calcitriol modestly promoted osteoclast maturation, it strongly inhibited osteoclast lineage commitment from its progenitor monocyte by increasing Smad1 transcription via vitamin D receptor and enhancing BMP-Smad1 activation, which in turn led to increased IκBα expression and decreased NF-κB activation and NFATc1 expression, with IκBα being a Smad1 target gene...
March 31, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28366454/postnatal-calvarial-skeletal-stem-cells-expressing-prx1-reside-exclusively-in%C3%A2-the-calvarial-sutures-and-are-required-for-bone-regeneration
#15
Katarzyna Wilk, Shu-Chi A Yeh, Luke J Mortensen, Sasan Ghaffarigarakani, Courtney M Lombardo, Seyed Hossein Bassir, Zahra A Aldawood, Charles P Lin, Giuseppe Intini
Post-natal skeletal stem cells expressing PRX1 (pnPRX1+) have been identified in the calvaria and in the axial skeleton. Here we characterize the location and functional capacity of the calvarial pnPRX1(+) cells. We found that pnPRX1(+) reside exclusively in the calvarial suture niche and decrease in number with age. They are distinct from preosteoblasts and osteoblasts of the sutures, respond to WNT signaling in vitro and in vivo by differentiating into osteoblasts, and, upon heterotopic transplantation, are able to regenerate bone...
April 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28365001/meprin-%C3%AE-and-bmp-1-are-differentially-regulated-by-cacl2
#16
Janna Schneppenheim, Franka Scharfenberg, Ralph Lucius, Christoph Becker-Pauly, Philipp Arnold
The two metalloproteases meprin β and bone morphogenetic protein 1 (BMP-1) are both members of the astacin protease family. They share specificity for negatively charged residues around the scissile bond and they are expressed in overlapping compartments of the human body. One important proteolytic substrate they share is pro-collagen I. Ablation of one of the two proteases however leads to different collagen I associated phenotypes in vivo. Over the last years calcium emerged as a regulator for the proteolytic activity of both enzymes...
March 19, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28363660/expanding-role-of-percutaneous-ablative-and-consolidative-treatments-for-musculoskeletal-tumours
#17
REVIEW
A N Kurup, M R Callstrom
Interventional approaches to musculoskeletal tumours have significantly changed over the last several years, and new treatments continue to be developed. All ablative modalities are currently applied to the treatment of bone tumours, including radiofrequency, cryo-, microwave, and laser ablation devices. Indications for ablation of bone and soft-tissue tumours have expanded beyond palliation of painful bone metastases and eradication of osteoid osteomas to the local control of oligometastatic disease from a number of primary tumours and ablation of desmoid tumours...
March 28, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28362393/two-techniques-to-create-hypoparathyroid-mice-parathyroidectomy-using-gfp-glands-and-diphtheria-toxin-mediated-parathyroid-ablation
#18
Ruiye Bi, Yi Fan, En Luo, Quan Yuan, Michael Mannstadt
Hypoparathyroidism (HP) is a disorder characterized by low levels of PTH which lead to hypocalcemia, hyperphosphatemia, and low bone turnover. The most common cause of the disease is accidental removal of the parathyroid glands during thyroid surgery. Novel therapies for HP are needed, but testing them requires reliable animal models of acquired HP. Here, we demonstrate the generation of two mouse models of acquired HP. In the GFP-PTX model, mice with green fluorescent protein (GFP) expressed specifically in the parathyroids (PTHcre-mTmG) were created by crossing PTHcre(+) mice with Rosa-mTmG(fl/fl) mice...
March 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28360474/an-intra-thoracic-follicular-carcinoma-of-thyroid-an-uncommon-presentation
#19
Surya Kant, Anand Srivastava, Rahul Kumar, Ajay Kumar Verma, Anand Kumar Mishra, Nuzhat Husain
Follicular carcinoma of thyroid is the second most common type of carcinoma of thyroid, and it may metastasize to bone, lung, brain, and skin. However, the initial presentation of follicular carcinoma of the thyroid as a large intrathoracic mass without any symptoms of thyroid gland enlargement and dysfunction is very rare. We hereby report a case of a 50-year-old male who presented with chief complaints of chest and low back pain. Preliminary evaluation led to the provisional diagnosis of left-sided intrathoracic mass with vertebral metastasis which was suspected to be a case of bronchogenic carcinoma with distant metastasis...
March 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28357077/circulating-osteocyte-derived-exosomes-contain-mirnas-which-are-enriched-in-exosomes-from-mlo-y4-cells
#20
Mari Sato, Tomohide Suzuki, Mitsuoki Kawano, Masato Tamura
Signaling molecules produced by osteocytes have been proposed to serve as soluble factors that contribute to bone remodeling, as well as to homeostasis of other organs. However, to the best of our knowledge, there are currently no studies investigating the role of osteocyte-secreted exosomes. In the present study, ablation of osteocytes in mice [osteocyte-less (OL)] was used to examine the microRNA (miRNA) levels of plasma-circulating exosomes. In order to investigate the function of osteocyte-secreted exosomes, exosomes derived from MLO-Y4 cells were extracted and their miRNA expression levels were examined using miRNA array analysis and deep sequencing...
February 2017: Biomedical Reports
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