Tuulia Malén, Severi Santavirta, Sven De Maeyer, Jouni Tuisku, Valtteri Kaasinen, Tuomas Kankare, Janne Isojärvi, Juha Rinne, Jarmo Hietala, Pirjo Nuutila, Lauri Nummenmaa
PURPOSE: Aberrant dopaminergic function is linked with motor, psychotic, and affective symptoms, but studies have typically compared a single patient group with healthy controls. METHODS: Here, we investigated the variation in striatal (caudate nucleus, nucleus accumbens, and putamen) and thalamic type 2 dopamine receptor (D2 R) availability using [11 C]raclopride positron emission tomography (PET) data from a large sample of 437 humans including healthy controls, and subjects with Parkinson's disease (PD), antipsychotic-naïve schizophrenia, severe violent behavior, pathological gambling, depression, and overweight...
2024: NeuroImage: Clinical