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Hydrogen peroxide

Jozef Kováčik, Sławomir Dresler, Petr Babula
Short-term (24 h) responses of Cladonia arbuscula subsp. mitis (formerly known as Cladina and this name is used to distinguish the tested species) and Cladonia furcata to nickel (Ni2+ ) excess (10 or 100 μM) were compared. Cladonia accumulated more Ni at higher Ni dose (1.717 mg total Ni/g DW), K amount was unaffected and Ca amount decreased in Cladina only. Fluorescence microscopy detection of total/general ROS and hydrogen peroxide showed Ni-stimulated increase in both species being more pronounced in Cladonia and in mycobiont partner mainly...
March 6, 2018: Plant Physiology and Biochemistry: PPB
Dariusz Dziga, Anna Maksylewicz, Magdalena Maroszek, Sylwia Marek
Under some conditions the growth of toxic cyanobacteria must be controlled by treatment with algicidal compounds. Hydrogen peroxide has been proposed as an efficient and relatively safe chemical which can remove cyanobacteria from the environment selectively, without affecting other microorganisms. However, the uncontrolled release of secondary metabolites, including toxins may occur after such a treatment. Our proposal presented in this paper concerns fast biodegradation of microcystin released after cell lysis induced by hydrogen peroxide...
March 15, 2018: Acta Biochimica Polonica
Karamat Mohammad, Paméla Dakik, Younes Medkour, Mélissa McAuley, Darya Mitrofanova, Vladimir I Titorenko
The concentrations of some key metabolic intermediates play essential roles in regulating the longevity of the chronologically aging yeast Saccharomyces cerevisiae . These key metabolites are detected by certain ligand-specific protein sensors that respond to concentration changes of the key metabolites by altering the efficiencies of longevity-defining cellular processes. The concentrations of the key metabolites that affect yeast chronological aging are controlled spatially and temporally. Here, we analyze mechanisms through which the spatiotemporal dynamics of changes in the concentrations of the key metabolites influence yeast chronological lifespan...
March 15, 2018: International Journal of Molecular Sciences
Thomas George Back, Kai N Sands, Tyler A Tuck
Selenium compounds play an important role in redox homeostasis in living organisms. One of their major functions is to suppress the harmful effects of hydrogen peroxide, hydroperoxides and downstream reactive oxygen species that lead to oxidative stress, which has in turn been implicated in many diseases and degenerative conditions. The glutathione peroxidase (GPx) family of selenoenzymes plays a key protective role by catalyzing the reduction of peroxides with glutathione. Considerable effort has been expended toward the discovery of small-molecule selenium compounds that mimic GPx...
March 14, 2018: Chemistry: a European Journal
Chen Chen, Wenzhong Hu, Ruidong Zhang, Aili Jiang, Chenghui Liu
BACKGROUND: Effect of hydrogen sulfide (H2 S) on inhibiting surface whitening of fresh-cut carrots was investigated. Whitening index, H2 O2 and malondialdehyde (MDA) contents, the activities of catalase (CAT), ascorbate peroxidase (APX), glutathione reductase (GR), phenylalanine ammonialyase (PAL), polyphenol oxidase (PPO) and peroxidase (POD) and antioxidant capacities were evaluated. RESULTS: H2 S treatment significantly inhibited the surface whitening of fresh-cut carrots (P < 0...
March 14, 2018: Journal of the Science of Food and Agriculture
Kosuke Dodo, Tadashi Shimizu, Jun Sasamori, Kazuyuki Aihara, Naoki Terayama, Shuhei Nakao, Katsuya Iuchi, Masahiro Takahashi, Mikiko Sodeoka
We previously developed IM-54 as a novel type of inhibitor of hydrogen-peroxide-induced necrotic cell death. Here, we examined its cell death inhibition profile. IM-54 was found to selectively inhibit oxidative stress-induced necrosis, but it did not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis. IM-17 , an IM derivative having improved water-solubility and metabolic stability, was developed and confirmed to retain necrosis-inhibitory activity. IM-17 showed cardioprotective effects in an isolated rat heart model and an in vivo arrhythmia model, suggesting that IM derivatives may have therapeutic potential...
March 8, 2018: ACS Medicinal Chemistry Letters
Mary Guaraldi, Thomas B Shea
Objective: We examined genetic and dietary challenge on hippocampal oxidative damage. Mice expressing (ApoE+/+) or lacking apolipoprotein E (ApoE-/-) were maintained on a standard diet or a high fat /high cholesterol (challenge) diet for 11-31 weeks. Similar levels of oxidative species were observed for ApoE+/+ and -/- mice maintained on the basal diet. Method: However, treatment of ApoE-/- homogenates with hydrogen peroxide and iron increased oxidative species by >100%, indicating an equivalent amount of potential oxidative species in latent form...
2018: Open Neurology Journal
Cuimei Zhang, Shangli Shi
Drought severely limits global plant distribution and agricultural production. Elucidating the physiological and molecular mechanisms governing alfalfa stress responses will contribute to the improvement of drought tolerance in leguminous crops. In this study, the physiological and proteomic responses of two alfalfa ( Medicago sativa L.) varieties contrasting in drought tolerance, Longzhong (drought-tolerant) and Gannong No. 3 (drought-sensitive), were comparatively assayed when seedlings were exposed to -1...
2018: Frontiers in Plant Science
Yanchen Tian, Min Fan, Zhaoxia Qin, Hongjun Lv, Minmin Wang, Zhe Zhang, Wenying Zhou, Na Zhao, Xiaohui Li, Chao Han, Zhaojun Ding, Wenfei Wang, Zhi-Yong Wang, Ming-Yi Bai
Hydrogen peroxide (H2 O2 ) is an important signaling molecule in plant developmental processes and stress responses. However, whether H2 O2 -mediated signaling crosstalks with plant hormone signaling is largely unclear. Here, we show that H2 O2 induces the oxidation of the BRASSINAZOLE-RESISTANT1 (BZR1) transcription factor, which functions as a master regulator of brassinosteroid (BR) signaling. Oxidative modification enhances BZR1 transcriptional activity by promoting its interaction with key regulators in the auxin-signaling and light-signaling pathways, including AUXIN RESPONSE FACTOR6 (ARF6) and PHYTOCHROME INTERACTING FACTOR4 (PIF4)...
March 14, 2018: Nature Communications
Matthew Tien, Aretha Fiebig, Sean Crosson
Cells adapt to shifts in their environment by remodeling transcription. Measuring changes in transcription at the genome scale is now routine, but defining the functional significance of individual genes within large gene expression datasets remains a major challenge. We applied a network-based algorithm to interrogate publicly available gene expression data to predict genes that serve major functional roles in Caulobacter crescentus stress survival. This approach identified GsrN, a conserved small RNA that is directly activated by the general stress sigma factor, σT , and functions as a potent post-transcriptional regulator of survival across distinct conditions including osmotic and oxidative stress...
March 14, 2018: ELife
Marcus Reitti, Ramani Gurubrahamam, Melanie Walther, Erik Lindstedt, Berit Olofsson
Two transition-metal-free methods to access substituted phenols via the arylation of silanols or hydrogen peroxide with diaryliodonium salts are presented. The complementary reactivity of the two nucleophiles allows synthesis of a broad range of phenols without competing aryne formation, as illustrated by the synthesis of the anesthetic Propofol. Furthermore, silyl-protected phenols can easily be obtained, which are suitable for further transformations.
March 14, 2018: Organic Letters
Sylwia Bloch, Bożena Nejman-Faleńczyk, Karolina Pierzynowska, Ewa Piotrowska, Alicja Węgrzyn, Christelle Marminon, Zouhair Bouaziz, Pascal Nebois, Joachim Jose, Marc Le Borgne, Luciano Saso, Grzegorz Węgrzyn
Oxidative stress may be the major cause of induction of Shiga toxin-converting (Stx) prophages from chromosomes of Shiga toxin-producing Escherichia coli (STEC) in human intestine. Thus, we aimed to test a series of novel antioxidant compounds for their activities against prophage induction, thus, preventing pathogenicity of STEC. Forty-six compounds (derivatives of carbazole, indazole, triazole, quinolone, ninhydrine, and indenoindole) were tested. Fifteen of them gave promising results and were further characterized...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
Lisa Milazzo, Stefan Hofbauer, Barry D Howes, Thomas Gabler, Paul G G Furtmüller, Christian Obinger, Giulietta Smulevich
Coproheme decarboxylases (ChdC) catalyse the hydrogen peroxide-mediated conversion of coproheme to heme b. This work compares the structure and function of wild-type (WT) coproheme decarboxylase from Listeria monocytogenes and its M149A, Q187A, and M149A/Q187A mutants. The UV-vis, resonance Raman and electron paramagnetic resonance spectroscopies clearly show that the ferric form of the WT protein is a pentacoordinate quantum mechanically mixed-spin state, which is very unusual in biological systems. Exchange of the Met149 residue to Ala dramatically alters the heme coordination, which becomes a 6 coordinate low spin species with the amide nitrogen atom of the Q187 residue bound to the heme iron...
March 14, 2018: Biochemistry
Luz I Valenzuela-García, Víctor M Ayala-García, Ana G Regalado-García, Peter Setlow, Mario Pedraza-Reyes
The absence of base excision repair (BER) proteins involved in processing ROS-promoted genetic insults activates a DNA damage scanning (DisA)-dependent checkpoint event in outgrowing Bacillus subtilis spores. Here, we report that genetic disabling of transcription-coupled repair (TCR) or nucleotide excision repair (NER) pathways severely affected outgrowth of ΔdisA spores, and much more so than the effects of these mutations on log phase growth. This defect delayed the first division of spore's nucleoid suggesting that unrepaired lesions affected transcription and/or replication during outgrowth...
March 13, 2018: MicrobiologyOpen
Simona Adesso, Rosario Russo, Andrea Quaroni, Giuseppina Autore, Stefania Marzocco
Astragalus membranaceus , dried root extract, also known as Astragali radix , is used in traditional Chinese medicine as a tonic remedy. Moreover, it has been reported that Astragalus membranaceus could attenuate intestinal inflammation; however, the underlying mechanism for its anti-inflammatory activity in intestinal epithelial cells (IECs) remains unclear. In this study, we evaluated Astragalus membranaceus extract (5-100 µg/mL) in a model of inflammation and oxidative stress for IECs. We showed that Astragalus membranaceus extract reduced the inflammatory response induced by lipopolysaccharide from E...
March 10, 2018: International Journal of Molecular Sciences
C Bersezio, P Vildósola, M Sáez, F Sánchez, R Vernal, O B Oliveira, G Jorquera, J Basualdo, A Loguercio, E Fernández
OBJECTIVE: This randomized clinical trial evaluated the effect of 35% hydrogen peroxide in comparison with 37% carbamide peroxide in a nonvital bleaching technique of "walking bleaching" (four sessions of treatment) on periodontal markers: nuclear factor kappa B-ligand (RANK-L-process of root resorption marker) and interleukin 1β (IL-1β-inflammatory response marker). METHODS AND MATERIALS: Fifty volunteers presenting with discoloration of nonvital teeth and endodontic treatment in good condition participated...
March 13, 2018: Operative Dentistry
Ivan Andreevich Yaremenko, Gabriel Dos Passos Gomes, Peter Sergeevich Radulov, Yulia Yur'evna Belyakova, Anatoliy Evgen'evich Vilikotskiy, Vera Andreevna Vil', Alexander A Korlyukov, Gennady Ivanovich Nikishin, Igor V Alabugin, Alexander Olegovich Terent'ev
Reactions of 1,5-diketones with H2O2 open an ozone-free approach to ozonides. Bridged ozonides are formed readily at the room temperature in the presence of strong Brønsted or Lewis acids such as H2SO4, p-TsOH, HBF4, or BF3•Et2O. The expected bridged tetraoxanes, the products of double H2O2 addition, were not detected. This procedure is readily scalable to produce gram quantities of the ozonides. Bridged ozonides are stable and can be useful as building block for bioconjugation and further synthetic transformations...
March 13, 2018: Journal of Organic Chemistry
Sadia Kabir, Kateryna Artyushkova, Alexey Serov, Plamen Atanassov
This study elucidates the synthesis-structure-property correlations of nitrogen moieties present in nitrogen functionalized graphene nanomaterials towards oxygen reduction reactions and their electrochemical pathways in acidic and alkaline electrolytes. Porous three-dimensional nitrogen-doped graphene nanosheets (N/3D-GNS) were fabricated using the Sacrificial Support Method (SSM) and doped with nitrogen using 10 at.% NH3 under thermal pyrolysis at T= 650°C, 850°C and 1050°C for evaluating the nitrogen species formed under different temperatures...
March 13, 2018: ACS Applied Materials & Interfaces
Junbo Zhang, Qi Shao, Ying Zhang, Shuxing Bai, Yonggang Feng, Xiaoqing Huang
Although direct hydrogen (H2 ) oxidation to hydrogen peroxide (H2 O2 ) is considered as a promising strategy for direct H2 O2 synthesis, the desirable conversion efficiency remains formidable challenge. Herein, highly active and selective direct H2 oxidation to H2 O2 is achieved by using hollow Pd-Sn intermetallic nanoparticles (NPs) as the catalysts. By tuning the catalytic solvents and catalyst supports, the efficiency of direct H2 oxidation to H2 O2 can be optimized well with the hollow Pd2 Sn NPs/P25 exhibiting H2 O2 selectivity up to 80...
March 13, 2018: Small
Trisha M Finlay, Alexandra L Palmer, Shalina S Ousman
Neutrophils are essential in the fight against invading pathogens. They utilize antimicrobial effector mechanisms such as phagocytosis, release of proteases and other antimicrobial products, robust oxidative bursts, and NETs to combat infections. Neutrophils also modulate immune responses through the production of eicosanoids, cytokines and chemokines as well as via direct communication with other immune cells. This system of high intensity offense against pathogens is exquisitely balanced through regulation to limit damage to host tissue...
March 13, 2018: Immunology
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