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https://www.readbyqxmd.com/read/29766047/a-transient-dopamine-signal-represents-avoidance-value-and-causally-influences-the-demand-to-avoid
#1
Katherine J Pultorak, Scott A Schelp, Dominic P Isaacs, Gregory Krzystyniak, Erik B Oleson
While an extensive literature supports the notion that mesocorticolimbic dopamine plays a role in negative reinforcement, recent evidence suggests that dopamine exclusively encodes the value of positive reinforcement. In the present study, we employed a behavioral economics approach to investigate whether dopamine plays a role in the valuation of negative reinforcement. Using rats as subjects, we first applied fast-scan cyclic voltammetry (FSCV) to determine that dopamine concentration decreases with the number of lever presses required to avoid electrical footshock (i...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29573086/electrochemical-measurement-of-dopamine-release-and-uptake-in-zebrafish-following-treatment-with-carboplatin
#2
Michael A Johnson, Thomas Field, Mimi Shin, Chase Stucky, Joseph Loomis
Post chemotherapy cognitive impairment, also known as 'chemobrain,' is a neurological condition in which cognitive function is impaired as a result of cancer chemotherapy treatment. In this work, we used fast-scan cyclic voltammetry (FSCV) to measure electrically evoked dopamine release and uptake in whole brain preparations from zebrafish that have been treated with carboplatin, an agent associated with chemobrain. We administered carboplatin by addition to the fish's tank water or their food. One week of treatment with 100 µM carboplatin in the water was needed to significantly impair dopamine release (~40% of control); however, only one day of treatment through the zebrafish's food was needed to cause a similar impairment...
March 23, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29507426/exercise-ameliorates-motor-deficits-and-improves-dopaminergic-functions-in-the-rat-hemi-parkinson-s-model
#3
Yuan-Hao Chen, Tung-Tai Kuo, Jen-Hsin Kao, Eagle Yi-Kung Huang, Tsung-Hsun Hsieh, Yu-Ching Chou, Barry J Hoffer
To determine the influences of exercise on motor deficits and dopaminergic transmission in a hemiparkinson animal model, we measured the effects of exercise on the ambulatory system by estimating spatio-temporal parameters during walking, striatal dopamine (DA) release and reuptake and synaptic plasticity in the corticostriatal pathway after unilateral 6-OHDA lesions. 6-OHDA lesioned hemiparkinsonian rats were exercised on a fixed speed treadmill for 30 minutes per day. Controls received the same lesion but no exercise...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324402/c-fscv-compressive-fast-scan-cyclic-voltammetry-for-brain-dopamine-recording
#4
Hossein Zamani, Hamid Reza Bahrami, Preeti Chalwadi, Paul A Garris, Pedram Mohseni
This paper presents a novel compressive sensing framework for recording brain dopamine levels with fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode. Termed compressive FSCV (C-FSCV), this approach compressively samples the measured total current in each FSCV scan and performs basic FSCV processing steps, e.g., background current averaging and subtraction, directly with compressed measurements. The resulting background-subtracted faradaic currents, which are shown to have a block-sparse representation in the discrete cosine transform domain, are next reconstructed from their compressively sampled counterparts with the block sparse Bayesian learning algorithm...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29286231/electrochemical-investigation-of-the-interaction-between-catecholamines-and-atp
#5
Zahra Taleat, Judith Estévez-Herrera, José D Machado, Johan Dunevall, Andrew G Ewing, Ricardo Borges
The study of the colligative properties of adenosine 5'-triphosphate (ATP) and catecholamines has received the attention of scientists for decades, as they could explain the capabilities of secretory vesicles (SVs) to accumulate neurotransmitters. In this Article, we have applied electrochemical methods to detect such interactions in vitro, at the acidic pH of SVs (pH 5.5) and examined the effect of compounds having structural similarities that correlate with functional groups of ATP (adenosine, phosphoric acid and sodium phosphate salts) and catecholamines (catechol)...
February 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29243477/electrochemical-selectivity-achieved-using-a-double-voltammetric-waveform-and-partial-least-squares-regression-differentiating-endogenous-hydrogen-peroxide-fluctuations-from-shifts-in-ph
#6
Carl J Meunier, Edwin C Mitchell, James G Roberts, Jonathan V Toups, Gregory S McCarty, Leslie A Sombers
Hydrogen peroxide (H2 O2 ) is a reactive oxygen species that serves as an important signaling molecule in normal brain function. At the same time, excessive H2 O2 concentrations contribute to myriad pathological consequences resulting from oxidative stress. Studies to elucidate the diverse roles that H2 O2 plays in complex biological environments have been hindered by the lack of robust methods for probing dynamic H2 O2 fluctuations in living systems with molecular specificity. Background-subtracted fast-scan cyclic voltammetry at carbon-fiber microelectrodes provides a method of detecting rapid H2 O2 fluctuations with high temporal and spatial resolution in brain tissue...
February 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29191006/selective-and-mechanically-robust-sensors-for-electrochemical-measurements-of-real-time-hydrogen-peroxide-dynamics-in-vivo
#7
Leslie R Wilson, Sambit Panda, Andreas C Schmidt, Leslie A Sombers
Hydrogen peroxide (H2 O2 ) is an endogenous molecule that plays several important roles in brain function: it is generated in cellular respiration, serves as a modulator of dopaminergic signaling, and its presence can indicate the upstream production of more aggressive reactive oxygen species (ROS). H2 O2 has been implicated in several neurodegenerative diseases, including Parkinson's disease (PD), creating a critical need to identify mechanisms by which H2 O2 modulates cellular processes in general and how it affects the dopaminergic nigrostriatal pathway, in particular...
January 2, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29182309/fast-scan-cyclic-voltammetry-chemical-sensing-in-the-brain-and-beyond
#8
James G Roberts, Leslie A Sombers
No abstract text is available yet for this article.
January 2, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29177248/detection-of-norepinephrine-in-whole-blood-via-fast-scan-cyclic-voltammetry
#9
Evan N Nicolai, James K Trevathan, Erika K Ross, J Luis Lujan, Charles D Blaha, Kevin E Bennet, Kendall H Lee, Kip A Ludwig
Bioelectronic Medicines is an emerging field that capitalizes on minimally-invasive technology to stimulate the autonomic nervous system in order to evoke therapeutic biomolecular changes at the end-organ. The goal of Bioelectronic Medicines is to realize both 'precision and personalized' medicine. 'Precise' stimulation of neural circuitry creates biomolecular changes targeted exactly where needed to maximize therapeutic effects while minimizing off-target changes associated with side-effects. The therapy is then 'personalized' by utilizing implanted sensors to measure the biomolecular concentrations at, or near, the end-organ of interest and continually adjusting therapy to account for patient-specific biological changes throughout the day...
May 2017: IEEE International Symposium on Medical Measurements and Applications: Proceedings
https://www.readbyqxmd.com/read/29090830/a-novel-biosensor-with-high-signal-to-noise-ratio-for-real-time-measurement-of-dopamine-levels-in-vivo
#10
Akimasa Ishida, Atsushi Imamura, Yoshitomo Ueda, Takeshi Shimizu, Ryosuke Marumoto, Cha-Gyun Jung, Hideki Hida
Fast-scan cyclic voltammetry (FSCV) is an established method for measuring dopamine (DA) levels in the brain in real time. However, it is difficult to discriminate DA from other monoamines such as serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). We report a novel DA-specific biosensor consisting of a carbon-fiber electrode coated with an ion-exchange membrane, a layer containing monoamine oxidase B, and a cellulose membrane. We performed FSCV using the probe to monitor the amount of DA in vitro and in vivo...
May 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29063091/a-baseline-drift-detrending-technique-for-fast-scan-cyclic-voltammetry
#11
Mark DeWaele, Yoonbae Oh, Cheonho Park, Yu Min Kang, Hojin Shin, Charles D Blaha, Kevin E Bennet, In Young Kim, Kendall H Lee, Dong Pyo Jang
Fast scan cyclic voltammetry (FSCV) has been commonly used to measure extracellular neurotransmitter concentrations in the brain. Due to the unstable nature of the background currents inherent in FSCV measurements, analysis of FSCV data is limited to very short amounts of time using traditional background subtraction. In this paper, we propose the use of a zero-phase high pass filter (HPF) as the means to remove the background drift. Instead of the traditional method of low pass filtering across voltammograms to increase the signal to noise ratio, a HPF with a low cutoff frequency was applied to the temporal dataset at each voltage point to remove the background drift...
November 6, 2017: Analyst
https://www.readbyqxmd.com/read/28943284/evaluating-oral-flavorant-effects-on-nicotine-self-administration-behavior-and-phasic-dopamine-signaling
#12
Robert J Wickham, Eric J Nunes, Shannon Hughley, Phillip Silva, Sofia N Walton, Jinwoo Park, Nii A Addy
Understanding how tobacco product flavor additives, such as flavorants in electronic cigarettes, influence smoking behavior and addiction is critical for informing public health policy decisions regarding tobacco product regulation. Here, we developed a combined intraoral (i.o.) and intravenous (i.v.) self-administration paradigm in rats to determine how flavorants influence self-administration behavior. By combining i.o. flavorant delivery with fast scan cyclic voltammetry (FSCV) or i.v. nicotine self-administration in adult, male rats, we examined whether flavors alter phasic dopamine (DA) signaling and nicotine self-administration...
January 2018: Neuropharmacology
https://www.readbyqxmd.com/read/28918253/deep-brain-stimulation-of-the-medial-forebrain-bundle-elevates-striatal-dopamine-concentration-without-affecting-spontaneous-or-reward-induced-phasic-release
#13
Marianne Klanker, Matthijs Feenstra, Ingo Willuhn, Damiaan Denys
Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) induces rapid improvement of depressive symptoms in patients suffering from treatment-refractory major depressive disorder (MDD). It has been hypothesized that activation of the dopamine (DA) system contributes to this effect. To investigate whether DBS in the MFB affects DA release in the striatum, we combined DBS with fast-scan cyclic voltammetry (FSCV) in freely moving rats. Animals were implanted with a stimulating electrode at the border of the MFB and the ventral tegmental area, and a FSCV microelectrode in the ventromedial striatum to monitor extracellular DA during the acute onset of DBS and subsequent continued stimulation...
November 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28840722/multivariate-curve-resolution-for-signal-isolation-from-fast-scan-cyclic-voltammetric-data
#14
Justin A Johnson, Josh H Gray, Nathan T Rodeberg, R Mark Wightman
The use of multivariate analysis techniques, such as principal component analysis-inverse least-squares (PCA-ILS), has become standard for signal isolation from in vivo fast-scan cyclic voltammetric (FSCV) data due to its superior noise removal and interferent-detection capabilities. However, the requirement of collecting separate training data for PCA-ILS model construction increases experimental complexity and, as such, has been the source of recent controversy. Here, we explore an alternative method, multivariate curve resolution-alternating least-squares (MCR-ALS), to circumvent this issue while retaining the advantages of multivariate analysis...
September 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28795565/in-vivo-ambient-serotonin-measurements-at-carbon-fiber-microelectrodes
#15
Aya Abdalla, Christopher W Atcherley, Pavithra Pathirathna, Srimal Samaranayake, Beidi Qiang, Edsel Peña, Stephen L Morgan, Michael L Heien, Parastoo Hashemi
The mechanisms that control extracellular serotonin levels in vivo are not well-defined. This shortcoming makes it very challenging to diagnose and treat the many psychiatric disorders in which serotonin is implicated. Fast-scan cyclic voltammetry (FSCV) can measure rapid serotonin release and reuptake events but cannot report critically important ambient serotonin levels. In this Article, we use fast-scan controlled adsorption voltammetry (FSCAV), to measure serotonin's steady-state, extracellular chemistry...
September 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28758383/single-organic-droplet-collision-voltammogram-via-electron-transfer-coupled-ion-transfer
#16
Cheng Liu, Pekka Peljo, Xinjian Huang, Wenxue Cheng, Lishi Wang, Haiqiang Deng
Single-emulsion toluene oil droplets (femtoliter) containing a hydrophobic redox probe that are dispersed in water stochastically collide with an ultramicroelectrode (UME). The fast-scan cyclic voltammetry (FSCV) or Fourier-transformed sinusoidal voltammetry (FTSV) is applied: the UME was scanned with a fast, repetitive triangular, or sinusoidal potential, and its current in time/frequency domains were monitored. The electron transfer at the UME/oil interface is coupled with ion transfer at the oil/water interface...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28667509/hypocretin-receptor-1-blockade-produces-bimodal-modulation-of-cocaine-associated-mesolimbic-dopamine-signaling
#17
K A Levy, Z D Brodnik, J K Shaw, D A Perrey, Y Zhang, R A España
RATIONALE: Cocaine addiction is a chronic psychiatric disorder characterized by pathological motivation to obtain cocaine and behavioral and neurochemical hypersensitivity to cocaine-associated cues. These features of cocaine addiction are thought to be driven by aberrant phasic dopamine signaling. We previously demonstrated that blockade of the hypocretin receptor 1 (HCRTr1) attenuates cocaine self-administration and reduces cocaine-induced enhancement of dopamine signaling. Despite this evidence, the effects of HCRTr1 blockade on endogenous phasic dopamine release are unknown...
September 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28619545/blast-related-disinhibition-and-risk-seeking-in-mice-and-combat-veterans-potential-role-for-dysfunctional-phasic-dopamine-release
#18
A G Schindler, J S Meabon, K F Pagulayan, R C Hendrickson, K D Meeker, M Cline, G Li, C Sikkema, C W Wilkinson, D P Perl, M R Raskind, E R Peskind, J J Clark, D G Cook
Mild traumatic brain injury (mTBI) caused by exposure to high explosives has been called the "signature injury" of the wars in Iraq and Afghanistan. There is a wide array of chronic neurological and behavioral symptoms associated with blast-induced mTBI. However, the underlying mechanisms are not well understood. Here we used a battlefield-relevant mouse model of blast-induced mTBI and in vivo fast-scan cyclic voltammetry (FSCV) to investigate whether the mesolimbic dopamine system contributes to the mechanisms underlying blast-induced behavioral dysfunction...
October 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28617576/ex-vivo-measurement-of-electrically-evoked-dopamine-release-in-zebrafish-whole-brain
#19
Mimi Shin, Thomas M Field, Chase S Stucky, Mia N Furgurson, Michael A Johnson
Zebrafish (Danio rerio) have recently emerged as useful model organism for the study of neuronal function. Here, fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes was used to measure locally evoked dopamine release and uptake in zebrafish whole brain preparations and results were compared with those obtained from brain slices. Evoked dopamine release ([DA]max ) was similar in whole brain and sagittal brain slice preparations (0.49 ± 0.13 μM in whole brain and 0.59 ± 0.28 μM in brain slices)...
September 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28605373/modeling-fast-scan-cyclic-voltammetry-data-from-electrically-stimulated-dopamine-neurotransmission-data-using-qnsim1-0
#20
Rashed Harun, Christine M Grassi, Miranda J Munoz, Amy K Wagner
Central dopaminergic (DAergic) pathways have an important role in a wide range of functions, such as attention, motivation, and movement. Dopamine (DA) is implicated in diseases and disorders including attention deficit hyperactivity disorder, Parkinson's disease, and traumatic brain injury. Thus, DA neurotransmission and the methods to study it are of intense scientific interest. In vivo fast-scan cyclic voltammetry (FSCV) is a method that allows for selectively monitoring DA concentration changes with fine temporal and spatial resolution...
June 5, 2017: Journal of Visualized Experiments: JoVE
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