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Fast scan cyclic voltammetry

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https://www.readbyqxmd.com/read/29766664/tissue-engineered-nigrostriatal-pathway-for-treatment-of-parkinson-s-disease
#1
Laura A Struzyna, Kevin D Browne, Zachary D Brodnik, Justin C Burrell, James P Harris, H Isaac Chen, John A Wolf, Kate V Panzer, James Lim, John E Duda, Rodrigo A España, D Kacy Cullen
The classic motor deficits of Parkinson's disease are caused by degeneration of dopaminergic neurons in the substantia nigra pars compacta, resulting in the loss of their long-distance axonal projections that modulate the striatum. Current treatments only minimize the symptoms of this disconnection as there is no approach capable of replacing the nigrostriatal pathway. We are applying micro-tissue engineering techniques to create living, implantable constructs that mimic the architecture and function of the nigrostriatal pathway...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29766047/a-transient-dopamine-signal-represents-avoidance-value-and-causally-influences-the-demand-to-avoid
#2
Katherine J Pultorak, Scott A Schelp, Dominic P Isaacs, Gregory Krzystyniak, Erik B Oleson
While an extensive literature supports the notion that mesocorticolimbic dopamine plays a role in negative reinforcement, recent evidence suggests that dopamine exclusively encodes the value of positive reinforcement. In the present study, we employed a behavioral economics approach to investigate whether dopamine plays a role in the valuation of negative reinforcement. Using rats as subjects, we first applied fast-scan cyclic voltammetry (FSCV) to determine that dopamine concentration decreases with the number of lever presses required to avoid electrical footshock (i...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29762016/rapid-2-ms-interrogation-of-electrochemical-aptamer-based-sensor-response-using-intermittent-pulse-amperometry
#3
Mirelis Santos-Cancel, Robert Alexander Lazenby, Ryan J White
In this manuscript, we employ the technique intermittent pulse amperometry (IPA) to interrogate equilibrium and kinetic target binding to the surface of electrochemical, aptamer-based (E-AB) sensors, achieving as fast as 2 ms time resolution. E-AB sensors comprise an electrode surface modified with a flexible nucleic acid aptamer tethered at the 3'-terminus with a redox-active molecule. The introduction of a target changes the conformation and flexibility of the nucleic acid which alters the charge transfer rate of the appended redox molecule...
May 15, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29753165/diagnosis-of-egfr-exon21-l858r-point-mutation-as-lung-cancer-biomarker-by-electrochemical-dna-biosensor-based-on-reduced-graphene-oxide-functionalized-ordered-mesoporous-carbon-ni-oxytetracycline-metallopolymer-nanoparticles-modified-pencil-graphite-electrode
#4
Yalda Shoja, Ahmad Kermanpur, Fathallah Karimzadeh
In this present work we made a novel, fast, selective and sensitive electrochemical genobiosensor to detection of EGFR exon 21 point mutation based on two step electropolymerization of Ni(II)-oxytetracycline conducting metallopolymer nanoparticles (Ni-OTC NPs) on the surface of pencil graphite electrode (PGE) which was modified by reduced graphene oxide/carboxyl functionalized ordered mesoporous carbon (rGO/f-OMC) nanocomposite. ssDNA capture probe with amine groups at the5' end which applied as recognition element was immobilized on the rGO/f-OMC/PGE surface via the strong amide bond...
April 14, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29723641/contributions-of-dopaminergic-and-non-dopaminergic-neurons-to-vta-stimulation-induced-neurovascular-responses-in-brain-reward-circuits
#5
Marta Brocka, Cornelia Helbing, Daniel Vincenz, Thomas Scherf, Dirk Montag, Jürgen Goldschmidt, Frank Angenstein, Michael Lippert
Mapping the activity of the human mesolimbic dopamine system by BOLD-fMRI is a tempting approach to non-invasively study the action of the brain reward system during different experimental conditions. However, the contribution of dopamine release to the BOLD signal is disputed. To assign the actual contribution of dopaminergic and non-dopaminergic VTA neurons to the formation of BOLD responses in target regions of the mesolimbic system, we used two optogenetic approaches in rats. We either activated VTA dopaminergic neurons selectively, or dopaminergic and mainly glutamatergic projecting neurons together...
April 30, 2018: NeuroImage
https://www.readbyqxmd.com/read/29680617/a-novel-highly-selective-and-sensitive-detection-of-serotonin-based-on-ag-polypyrrole-cu-2-o-nanocomposite-modified-glassy-carbon-electrode
#6
S Selvarajan, A Suganthi, M Rajarajan
A silver/polypyrrole/copper oxide (Ag/PPy/Cu2 O) ternary nanocomposite was prepared by sonochemical and oxidative polymerization simple way, in which Cu2 O was decorated with Ag nanoparticles, and covered by polyprrole (PPy) layer. The as prepared materials was characterized by UV-vis-spectroscopy (UV-vis), FT-IR, X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), scanning electron microscopy (SEM) with EDX, high resolution transmission electron microscopy (HR-TEM) and X-ray photoelectron spectroscopy (XPS)...
June 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29658700/3d-printed-graphene-polylactic-acid-electrodes-promise-high-sensitivity-in-electroanalysis
#7
C Lorena Manzanares Palenzuela, Filip Novotný, Petr Krupička, Zdeněk Sofer, Martin Pumera
Additive manufacturing provides a unique tool for prototyping structures toward electrochemical sensing, due to its ability to produce highly versatile, tailored-shaped devices in a low-cost and fast way with minimized waste. Here we present 3D-printed graphene electrodes for electrochemical sensing. Ring- and disc-shaped electrodes were 3D-printed with a Fused Deposition Modeling printer and characterized using cyclic voltammetry and scanning electron microscopy. Different redox probes K3 Fe(CN)6 :K4 Fe(CN)6 , FeCl3 , ascorbic acid, Ru(NH3 )6 Cl3 , and ferrocene monocarboxylic acid) were used to assess the electrochemical performance of these devices...
April 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29602186/molecular-mechanisms-underlying-striatal-synaptic-plasticity-relevance-to-chronic-alcohol-consumption-and-seeking
#8
Kim T Blackwell, Armando G Salinas, Parul Tewatia, Brad English, Jeanette Hellgren Kotaleski, David M Lovinger
The striatum, the input structure of the basal ganglia, is a major site of learning and memory for goal-directed actions and habit formation. Spiny projection neurons of the striatum integrate cortical, thalamic, and nigral inputs to learn associations, with cortico-striatal synaptic plasticity as a learning mechanism. Signaling molecules implicated in synaptic plasticity are altered in alcohol withdrawal, which may contribute to overly strong learning and increased alcohol seeking and consumption. To understand how interactions among signaling molecules produce synaptic plasticity, we implemented a mechanistic model of signaling pathways activated by dopamine D1 receptors, acetylcholine receptors, and glutamate...
March 30, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29602178/ethanol-exposure-history-and-alcoholic-reward-differentially-alter-dopamine-release-in-the-nucleus-accumbens-to-a-reward-predictive-cue
#9
Amanda M Fiorenza, Tatiana A Shnitko, Kaitlin M Sullivan, Sudheer R Vemuru, Alexander Gomez-A, Julie Y Esaki, Charlotte A Boettiger, Claudio Da Cunha, Donita L Robinson
BACKGROUND: Conditioned stimuli (CS) that predict reward delivery acquire the ability to induce phasic dopamine release in the nucleus accumbens. This dopamine release may facilitate conditioned approach behavior, which often manifests as approach to the site of reward delivery (called 'goal-tracking') or to the CS itself (called 'sign-tracking'). Previous research has linked sign-tracking in particular to impulsivity and drug self-administration, and addictive drugs may promote the expression of sign-tracking...
March 30, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29594544/voltammetric-determination-of-the-escherichia-coli-dna-using-a-screen-printed-carbon-electrode-modified-with-polyaniline-and-gold-nanoparticles
#10
Nahid Shoaie, Mehdi Forouzandeh, Kobra Omidfar
The authors describe an electrochemical assay for fast detection of Escherichia coli (E. coli). It is based on a dual signal amplification strategy and the use of a screen-printed carbon electrode (SPCE) whose surface was modified with a polyaniline (PANI) film and gold nanoparticles (AuNPs) via cyclic voltammetry (CV). In the next step, avidin was covalently immobilized on the PANI/AuNP composite on the SPCE surface. Subsequently, the biotinylated DNA capture probe was immobilized onto the PANI/AuNP/avidin-modified SPCE by biotin-avidin interaction...
March 12, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29594397/microwave-assisted-synthesis-of-graphene-modified-cuo-nanoparticles-for-voltammetric-enzyme-free-sensing-of-glucose-at-biological-ph-values
#11
Faranak Foroughi, Mansour Rahsepar, Mohammad Jafar Hadianfard, Hasuck Kim
The effect of graphene nanosheets on the glucose sensing performance of CuO powders was investigated. CuO and graphene-modified CuO nanoparticles (NPs) were fabricated by microwave-assisted synthesis and characterized by X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy. The material was placed on a glassy carbon electrode (GCE) which then was characterized by cyclic voltammetry and chronoamperometry with respect to the capability of sensing glucose both at pH 13 and pH 7...
December 18, 2017: Mikrochimica Acta
https://www.readbyqxmd.com/read/29573086/electrochemical-measurement-of-dopamine-release-and-uptake-in-zebrafish-following-treatment-with-carboplatin
#12
Michael A Johnson, Thomas Field, Mimi Shin, Chase Stucky, Joseph Loomis
Post chemotherapy cognitive impairment, also known as 'chemobrain,' is a neurological condition in which cognitive function is impaired as a result of cancer chemotherapy treatment. In this work, we used fast-scan cyclic voltammetry (FSCV) to measure electrically evoked dopamine release and uptake in whole brain preparations from zebrafish that have been treated with carboplatin, an agent associated with chemobrain. We administered carboplatin by addition to the fish's tank water or their food. One week of treatment with 100 µM carboplatin in the water was needed to significantly impair dopamine release (~40% of control); however, only one day of treatment through the zebrafish's food was needed to cause a similar impairment...
March 23, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29524437/metabotropic-glutamate-receptor-modulation-of-dopamine-release-in-the-nucleus-accumbens-shell-is-unaffected-by-phencyclidine-pretreatment-in-vitro-assessment-using-fast-scan-cyclic-voltammetry-rat-brain-slices
#13
Ishan Gupta, Andrew M J Young
The non-competitive glutamate antagonist, phencyclidine is used in rodents to model behavioural deficits see in schizophrenia. Importantly, these deficits endure long after the cessation of short-term chronic treatment (sub-chronic), indicating that the drug treatment causes long-term changes in the physiology and/or chemistry of the brain. There is evidence that this may occur through glutamatergic modulation of mesolimbic dopamine release, perhaps involving metabotropic glutamate receptors (mGluR). This study sought to investigate the effect of sub-chronic phencyclidine pretreatment on modulation of dopamine neurotransmission by metabotropic glutamate receptors 2 and 5 (mGluR2 and mGluR5) in the nucleus accumbens shell in vitro, with the hypothesis that phencyclidine pretreatment would disrupt the mGluR-mediated modulation of dopamine release...
May 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29515787/effect-of-traumatic-brain-injury-on-nicotine-induced-modulation-of-dopamine-release-in-the-striatum-and-nucleus-accumbens-shell
#14
Yuan-Hao Chen, Tung-Tai Kuo, Eagle Yi-Kung Huang, Yu-Ching Chou, Yung-Hsiao Chiang, Barry J Hoffer, Jonathon Miller
Background: Traumatic brain injury is associated with substantial alterations in reward processing, but underlying mechanisms are controversial. Objective: A better understanding of alterations in dopamine (DA) release patterns from the dorsal striatum and nucleus accumbens shell (NAc) may provide insights into posttraumatic reward pathology. Materials and Methods: The patterns of DA release with or without exposure to nicotine in brain slices with striatum and NAc, isolated from Sprague-Dawley rats with 6 psi fluid percussion (FPI) or sham injury were analysis by using fast-scan cyclic voltammetry...
February 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29513711/a-novel-carbon-tipped-single-micro-optrode-for-combined-optogenetics-and-electrophysiology
#15
Dénes Budai, Attila D Vizvári, Zsolt K Bali, Balázs Márki, Lili V Nagy, Zoltán Kónya, Dániel Madarász, Nóra Henn-Mike, Csaba Varga, István Hernádi
Optical microelectrodes (optrodes) are used in neuroscience to transmit light into the brain of a genetically modified animal to evoke and record electrical activity from light-sensitive neurons. Our novel micro-optrode solution integrates a light-transmitting 125 micrometer optical fiber and a 9 micrometer carbon monofilament to form an electrical lead element, which is contained in a borosilicate glass sheathing coaxial arrangement ending with a micrometer-sized carbon tip. This novel unit design is stiff and slender enough to be used for targeting deep brain areas, and may cause less tissue damage compared with previous models...
2018: PloS One
https://www.readbyqxmd.com/read/29513513/diffusion-controlled-faradaic-charge-storage-in-high-performance-solid-electrolyte-gated-zinc-oxide-thin-film-transistors
#16
Premlal Balakrishna Pillai, Ashwani Kumar, Xiaoyao Song, Maria Merlyne De Souza
An electrochemical device capable of manifesting reversible charge storage at the interface of an active layer offers formidable advantages, such as low switching energy and long retention time, in realizing synaptic behavior for ultralow power neuromorphic systems. Contrary to a supercapacitor-based field-effect device that is prone to low memory retention due to fast discharge, a solid electrolyte-gated ZnO thin-film device exhibiting a battery-controlled charge storage mechanism via mobile charges at its interface with tantalum oxide is demonstrated...
March 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29510525/non-enzymatic-electrochemical-sensing-of-malathion-pesticide-in-tomato-and-apple-samples-based-on-gold-nanoparticles-chitosan-ionic-liquid-hybrid-nanocomposite
#17
Gulcin Bolat, Serdar Abaci
Malathion (MLT) is an organophosphorous type pesticide and having seriously high toxicity and electrochemical platforms for rapid, simple, inexpensive and sensitive determination of pesticides is still a special concern. This paper describes a simple preparation of a composite film consisting of ionic liquid (IL), chitosan (CS) and electrochemically synthesized gold nanoparticles (AuNPs) on single use pencil graphite electrodes (PGEs). The microscopic and electrochemical characterization of AuNP-CS-IL/PGE was studied using scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy...
March 4, 2018: Sensors
https://www.readbyqxmd.com/read/29480165/cvd-graphene-for-low-equivalent-series-resistance-in-rgo-cvd-graphene-ni-based-supercapacitors
#18
Young Hwi Kwon, Sunil Kumar, Joonho Bae, Yongho Seo
Reduced equivalent series resistance (ESR) is necessary, particularly at a high current density, for high performance supercapacitors, and the interface resistance between the current collector and electrode material is one of the main components of ESR. In this report, we have optimized chemical vapor deposition-grown graphene (CVD-G) on a current collector (Ni-foil) using reduced graphene oxide as an active electrode material to fabricate an electric double layer capacitor with reduced ESR. The CVD-G was grown at different cooling rates-20 °C min-1 , 40 °C min-1 and 100 °C min-1 -to determine the optimum conditions...
May 11, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29472642/role-of-trace-amine-associated-receptor-1-in-nicotine-s-behavioral-and-neurochemical-effects
#19
Jian-Feng Liu, Robert Seaman, Justin N Siemian, Rohan Bhimani, Bernard Johnson, Yanan Zhang, Qing Zhu, Marius C Hoener, Jinwoo Park, David M Dietz, Jun-Xu Li
Nicotine addiction and abuse remains a global health issue. To date, the fundamental neurobiological mechanism of nicotine addiction remains incompletely understood. Trace amine-associated receptor 1 (TAAR1) is thought to directly modulate dopaminergic system and are thought to be a neural substrate underlying addictive-like behaviors. We aimed to investigate the role of TAAR1 in nicotine addictive-like behaviors. TAAR1 expression after nicotine treatment was evaluated by western blotting. c-Fos immunofluorescence and in vivo fast-scan cyclic voltammetry were used to examine the activation of brain regions and dopamine release, respectively...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29447669/highly-sensitive-glucose-sensor-based-on-monodisperse-palladium-nickel-activated-carbon-nanocomposites
#20
Yağmur Koskun, Aysun Şavk, Betül Şen, Fatih Şen
Glucose enzyme biosensors have been used for a variety of applications such as medical diagnosis, bioprocess engineering, beverage industry and environmental scanning etc. and there is still a growing interest in glucose sensors. For this purpose, addressed herein, as a novel glucose sensor, highly sensitive activated carbon (AC) decorated monodisperse nickel and palladium alloy nanocomposites modified glassy carbon electrode (Ni-Pd@AC/GCE NCs) have been synthesized by in-situ reduction technique. Raman Spectroscopy (RS), X-ray Photoelectron Spectroscopy (XPS), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), cyclic voltammetry (CV) and chronoamperometry (CA) were used for the characterization of the prepared non-enzymatic glucose sensor...
June 20, 2018: Analytica Chimica Acta
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