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Fast scan cyclic voltammetry

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https://www.readbyqxmd.com/read/29350466/simultaneous-extraction-and-determination-of-trace-amounts-of-diclofenac-from-whole-blood-using-supported-liquid-membrane-microextraction-and-fast-fourier-transform-voltammetry
#1
Zahra Mofidi, Parviz Norouzi, Masumeh Sajadian, Mohammad Reza Ganjali
A novel, simple and inexpensive analytical technique based on flat sheet supported liquid membrane microextraction coupled with fast Fourier transform stripping cyclic voltammetry on a reduced graphene oxide carbon paste electrode was used for the extraction and online determination of diclofenac in whole blood. First, diclofenac was extracted from blood samples using a polytetrafluoroethylene membrane impregnated with 1-octanol and then into an acceptor solution, subsequently it was oxidized on a carbon paste electrode modified with reduced graphene oxide nano-sheets...
January 19, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29324402/c-fscv-compressive-fast-scan-cyclic-voltammetry-for-brain-dopamine-recording
#2
Hossein Zamani, Hamid Reza Bahrami, Preeti Chalwadi, Paul A Garris, Pedram Mohseni
This paper presents a novel compressive sensing framework for recording brain dopamine levels with fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode. Termed compressive FSCV (C-FSCV), this approach compressively samples the measured total current in each FSCV scan and performs basic FSCV processing steps, e.g., background current averaging and subtraction, directly with compressed measurements. The resulting background-subtracted faradaic currents, which are shown to have a block-sparse representation in the discrete cosine transform domain, are next reconstructed from their compressively sampled counterparts with the block sparse Bayesian learning algorithm...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29321525/exploring-the-consequences-of-social-defeat-stress-and-intermittent-ethanol-drinking-on-dopamine-dynamics-in-the-rat-nucleus-accumbens
#3
Alex L Deal, Joanne K Konstantopoulos, Jeff L Weiner, Evgeny A Budygin
The current study aimed to explore how presynaptic dopamine (DA) function is altered following brief stress episodes and chronic ethanol self-administration and whether these neuroadaptations modify the acute effects of ethanol on DA dynamics. We used fast-scan cyclic voltammetry to evaluate changes in DA release and uptake parameters in rat nucleus accumbens brain slices by analyzing DA transients evoked through single pulse electrical stimulation. Adult male rats were divided into four groups: ethanol-naïve or ethanol drinking (six week intermittent two-bottle choice) and stressed (mild social defeat) or nonstressed...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316144/quantitative-comparison-of-enzyme-immobilization-strategies-for-glucose-biosensing-in-real-time-using-fast-scan-cyclic-voltammetry-coupled-with-carbon-fiber-microelectrodes
#4
Samantha K Smith, Leyda Z Lugo-Morales, Christina Tang, Saahj P Gosrani, Christie A Lee, James G Roberts, Stephen W Morton, Gregory S McCarty, Saad A Khan, Leslie A Sombers
Electrochemical monitoring of non-electroactive species requires a biosensor that is stable and selective, with sensitivity to physiological concentrations of targeted analytes. We have combined glucose oxidase-modified carbon-fiber microelectrodes with fast-scan cyclic voltammetry for real-time measurements of glucose fluctuations in brain tissue. Work presented herein quantitatively compares three approaches to enzyme immobilization on the microelectrode surface - physical adsorption, hydrogel entrapment, and entrapment in electrospun nanofibers...
January 9, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29305920/nicotinic-acetylcholine-receptor-nachr-mediated-dopamine-release-in-larval-drosophila-melanogaster
#5
Poojan Pyakurel, Mimi Shin, B Jill Venton
Acetylcholine is an excitatory neurotransmitter in the central nervous system of insects and the nicotinic acetylcholine receptor (nAChR) is a target for neonicotinoid insecticides. Functional insect nAChRs are difficult to express in host cells, and hence difficult to study. In mammals, acetylcholine and nicotine evoke dopamine release, but the extent to which this mechanism is conserved in insects is unknown. In intact larval ventral nerve cords (VNCs), we studied dopamine evoked by acetylcholine, nicotine, or neonicotinoids...
January 3, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29301209/one-step-electrochemical-fabrication-of-reduced-graphene-oxide-gold-nanoparticles-nanocomposite-modified-electrode-for-simultaneous-detection-of-dopamine-ascorbic-acid-and-uric-acid
#6
Chang-Seuk Lee, Su Hwan Yu, Tae Hyun Kim
Here, we introduce the preparation of the hybrid nanocomposite-modified electrode consisting of reduced graphene oxide (RGO) and gold nanoparticles (AuNPs) using the one-step electrochemical method, allowing for the simultaneous and individual detection of dopamine (DA), ascorbic acid (AA), and uric acid (UA). RGO/AuNPs nanocomposite was formed on a glassy carbon electrode by the co-reduction of GO and Au3+ using the potentiodynamic method. The RGO/AuNPs nanocomposite-modified electrode was produced by subjecting a mixed solution of GO and Au3+ to cyclic sweeping from -1...
December 30, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29297512/the-protective-action-encoding-of-serotonin-transients-in-the-human-brain
#7
Rosalyn J Moran, Kenneth T Kishida, Terry Lohrenz, Ignacio Saez, Adrian W Laxton, Mark R Witcher, Stephen B Tatter, Thomas L Ellis, Paul Em Phillips, Peter Dayan, P Read Montague
The role of serotonin in human brain function remains elusive due, at least in part, to our inability to measure rapidly the local concentration of this neurotransmitter. We used fast-scan cyclic voltammetry to infer serotonergic signaling from the striatum of fourteen brains of human patients with Parkinson's disease. Here we report these novel measurements and show that they correlate with outcomes and decisions in a sequential investment game. We find that serotonergic concentrations transiently increase as a whole following negative reward prediction errors, while reversing when counterfactual losses predominate...
January 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29289718/a-high-fat-high-sugar-western-diet-alters-dorsal-striatal-glutamate-opioid-and-dopamine-transmission-in-mice
#8
Brandon M Fritz, Braulio Muñoz, Fuqin Yin, Casey Bauchle, Brady K Atwood
Understanding neuroadaptations involved in obesity is critical for developing new approaches to treatment. Diet-induced neuroadaptations within the dorsal striatum have the capacity to drive excessive food seeking and consumption. Five week old C57BL/6J mice consumed a high-fat, high-sugar 'western diet' (WD) or a control 'standard diet' (SD) for 16 weeks. Weight gain, glucose tolerance, and insulin tolerance were measured to confirm an obese-like state. Following these 16 weeks, electrophysiological recordings were made from medium spiny neurons (MSNs) in the medial (DMS) and lateral (DLS) portions of dorsal striatum to evaluate diet effects on neuronal excitability and synaptic plasticity...
December 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/29287121/high-fructose-corn-syrup-induces-metabolic-dysregulation-and-altered-dopamine-signaling-in-the-absence-of-obesity
#9
Allison M Meyers, Devry Mourra, Jeff A Beeler
The contribution of high fructose corn syrup (HFCS) to metabolic disorder and obesity, independent of high fat, energy-rich diets, is controversial. While high-fat diets are widely accepted as a rodent model of diet-induced obesity (DIO) and metabolic disorder, the value of HFCS alone as a rodent model of DIO is unclear. Impaired dopamine function is associated with obesity and high fat diet, but the effect of HFCS on the dopamine system has not been investigated. The objective of this study was to test the effect of HFCS on weight gain, glucose regulation, and evoked dopamine release using fast-scan cyclic voltammetry...
2017: PloS One
https://www.readbyqxmd.com/read/29286231/electrochemical-investigation-of-the-interaction-between-catecholamines-and-atp
#10
Zahra Taleat, Judith Estévez-Herrera, Jose David Machado, Johan Dunevall, Andrew G Ewing, Ricardo Borges
The study of the colligative properties of adenosine 5'-triphosphate (ATP) and catecholamines has received the attention of scientist for decades, as they could explain the capabilities of secretory vesicles (SVs) to accumulate neurotransmitters. In this paper, we have applied electrochemical methods to detect such interactions in vitro, at the acidic pH of SVs (pH =5.5) and examined the effect of compounds having structural similarities that correlate with functional groups of ATP (adenosine, phosphoric acid and sodium phosphate salts) and catecholamines (catechol)...
December 29, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29243477/electrochemical-selectivity-achieved-using-a-double-voltammetric-waveform-and-partial-least-squares-regression-differentiating-endogenous-hydrogen-peroxide-fluctuations-from-shifts-in-ph
#11
Carl J Meunier, Edwin C Mitchell, James G Roberts, Jonathan Vincent Toups, Gregory S McCarty, Leslie A Sombers
Hydrogen peroxide (H2O2) is a reactive oxygen species that serves as an important signaling molecule in normal brain function. At the same time, excessive H2O2 concentrations contribute to a myriad of pathological consequences resulting from oxidative stress. Studies to elucidate the diverse roles that H2O2 plays in complex biological environments have been hindered by the lack of robust methods for probing dynamic H2O2 fluctuations in living systems with molecular specificity. Background-subtracted fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes provides a method of detecting rapid H2O2 fluctuations with high temporal and spatial resolution in brain tissue...
December 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29239776/differential-release-of-dopamine-in-the-nucleus-accumbens-evoked-by-low-versus-high-frequency-medial-prefrontal-cortex-stimulation
#12
Daniel F Hill, Kate L Parent, Christopher W Atcherley, Stephen L Cowen, Michael L Heien
The medial prefrontal cortex (mPFC) coordinates goal-directed behaviors, which may be mediated through mPFC regulation of dopamine release in the nucleus accumbens (NAc). Furthermore, frequency-specific oscillatory activity between the frontal cortex and downstream structures may facilitate inter-region communication. Although high-frequency (e.g., 60 Hz) mPFC stimulation is known to increase basal dopamine levels in the NAc, little is known about how phasic dopamine release is affected by mPFC stimulation...
November 15, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29228949/a-mathematical-model-for-histamine-synthesis-release-and-control-in-varicosities
#13
Janet Best, H F Nijhout, Srimal Samaranayake, Parastoo Hashemi, Michael Reed
BACKGROUND: Histamine (HA), a small molecule that is synthesized from the amino acid histidine, plays an important role in the immune system where it is associated with allergies, inflammation, and T-cell regulation. In the brain, histamine is stored in mast cells and other non-neuronal cells and also acts as a neurotransmitter. The histamine neuron cell bodies are in the tuberomammillary (TM) nucleus of the hypothalamus and these neurons send projections throughout the central nervous system (CNS), in particular to the cerebral cortex, amygdala, basal ganglia, hippocampus, thalamus, retina, and spinal cord...
December 12, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29207203/a-rotaxane-scaffold-bearing-multiple-redox-centers-synthesis-surface-modification-and-electrochemical-properties
#14
Jean-Francois Nierengarten, Marie Steffenhagen, Alina Latus, Thi Minh Nguyet Trinh, Iwona Nierengarten, Ivan T Lucas, Suzanne Joiret, Jessem Landoulsi, Béatrice Delavaux-Nicot, Emmanuel Maisonhaute
A rotaxane scaffold incorporating two dithiolane anchoring units for the modification of gold surfaces has been functionalized with multiple copies of a redox unit, namely ferrocene. Surface modification has been first assessed at the single molecule level by atomic force microscopy (AFM) and scanning tunneling microscopy (STM) imaging, while tip enhanced Raman spectroscopy (TERS) provided the local vibrational signature of the ferrocenyl subunits of the rotaxanes grafted onto the gold surface. Finally, oxidation of the redox moieties within a rotaxane scaffold grafted onto gold microelectrodes has been investigated by ultrafast cyclic voltammetry...
December 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29206881/deletion-of-lynx1-reduces-the-function-of-%C3%AE-6-nicotinic-receptors
#15
Rell L Parker, Heidi C O'Neill, Beverley M Henley, Charles R Wageman, Ryan M Drenan, Michael J Marks, Julie M Miwa, Sharon R Grady, Henry A Lester
The α6 nicotinic acetylcholine receptor (nAChR) subunit is an attractive drug target for treating nicotine addiction because it is present at limited sites in the brain including the reward pathway. Lynx1 modulates several nAChR subtypes; lynx1-nAChR interaction sites could possibly provide drug targets. We found that dopaminergic cells from the substantia nigra pars compacta (SNc) express lynx1 mRNA transcripts and, as assessed by co-immunoprecipitation, α6 receptors form stable complexes with lynx1 protein, although co-transfection with lynx1 did not affect nicotine-induced currents from cell lines transfected with α6 and β2...
2017: PloS One
https://www.readbyqxmd.com/read/29191006/selective-and-mechanically-robust-sensors-for-electrochemical-measurements-of-real-time-hydrogen-peroxide-dynamics-in-vivo
#16
Leslie R Wilson, Sambit Panda, Andreas C Schmidt, Leslie A Sombers
The role of hydrogen peroxide (H2O2) in the complex environment of the brain is not well understood. H2O2 plays several important roles - for instance, it serves as a key chemical player in normal physiological processes such as cellular respiration, a modulator of dopaminergic signaling, and its presence can indicate the upstream production of more aggressive and short-lived reactive oxygen species (ROS). As such, H2O2 has been implicated in several neurodegenerative diseases, including the slow destruction of dopaminergic neurons in Parkinson's disease (PD)...
December 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29185481/methamphetamine-induces-dopamine-release-in-the-nucleus-accumbens-through-a-sigma-receptor-mediated-pathway
#17
David M Hedges, J Daniel Obray, Jordan T Yorgason, Eun Young Jang, Vajira K Weerasekara, Joachim D Uys, Frederick P Bellinger, Scott C Steffensen
Methamphetamine (METH) is a drug with a high addictive potential that is widely abused across the world. While it is known that METH dysregulates both dopamine transmission and dopamine reuptake, the specific mechanism of action remains obscure. One promising target of METH is the sigma receptor, a chaperone protein located on the membrane of the endoplasmic reticulum. Using fast-scan cyclic voltammetry, we show that METH-enhancement of evoked dopamine release and basal efflux is dependent on sigma receptor activation...
November 29, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29182309/fast-scan-cyclic-voltammetry-chemical-sensing-in-the-brain-and-beyond
#18
James G Roberts, Leslie A Sombers
In this review we will describe the electroanalytical method known as fast-scan cyclic voltammetry (FSCV), how it has advanced over the years, and in what way(s) it is impacting other sciences. To begin, a brief history will be discussed. The various means to enhance chemical selectivity by manipulating the applied potential will be covered. Some limitations of this electroanalytical method will be highlighted to inform and provide clarity to the scientific community. The intent is to seek out effective solutions to the difficult problems associated with the technique, so that the field will continue to flourish...
November 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29177248/detection-of-norepinephrine-in-whole-blood-via-fast-scan-cyclic-voltammetry
#19
Evan N Nicolai, James K Trevathan, Erika K Ross, J Luis Lujan, Charles D Blaha, Kevin E Bennet, Kendall H Lee, Kip A Ludwig
Bioelectronic Medicines is an emerging field that capitalizes on minimally-invasive technology to stimulate the autonomic nervous system in order to evoke therapeutic biomolecular changes at the end-organ. The goal of Bioelectronic Medicines is to realize both 'precision and personalized' medicine. 'Precise' stimulation of neural circuitry creates biomolecular changes targeted exactly where needed to maximize therapeutic effects while minimizing off-target changes associated with side-effects. The therapy is then 'personalized' by utilizing implanted sensors to measure the biomolecular concentrations at, or near, the end-organ of interest and continually adjusting therapy to account for patient-specific biological changes throughout the day...
May 2017: IEEE International Symposium on Medical Measurements and Applications: Proceedings
https://www.readbyqxmd.com/read/29176843/hiv-1-and-cocaine-disrupt-dopamine-reuptake-and-medium-spiny-neurons-in-female-rat-striatum
#20
Mehrak Javadi-Paydar, Robert F Roscoe, Adam R Denton, Charles F Mactutus, Rosemarie M Booze
HIV-1 and addictive drugs, such as cocaine (COC), may act in combination to produce serious neurological complications. In the present experiments, striatal brain slices from HIV-1 transgenic (Tg) and F344 control female rats were studied. First, we examined dopamine (DA) reuptake in control, HIV-1, COC-treated (5µM) and HIV-1+COC-treated, striatal slices using fast scan cyclic voltammetry. COC-treated striatal slices from F344 control animals significantly increased DA reuptake time (T80), relative to untreated control slices...
2017: PloS One
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