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Fast scan cyclic voltammetry

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https://www.readbyqxmd.com/read/28342771/the-area-postrema-ap-and-the-parabrachial-nucleus-pbn-are-important-sites-for-salmon-calcitonin-sct-to-decrease-evoked-phasic-dopamine-release-in-the-nucleus-accumbens-nac
#1
Lynda Whiting, James E McCutcheon, Christina N Neuner-Boyle, Mitchell F Roitman, Thomas A Lutz
The pancreatic hormone amylin and its agonist salmon calcitonin (sCT) act via the area postrema (AP) and the lateral parabrachial nucleus (PBN) to reduce food intake. Investigations of amylin and sCT signaling in the ventral tegmental area (VTA) and nucleus accumbens (NAc) suggest that the eating inhibitory effect of amylin is, in part, mediated through the mesolimbic 'reward' pathway. Indeed, administration of the sCT directly to the VTA decreased phasic dopamine release (DA) in the NAc. However, it is not known if peripheral amylin modulates the mesolimbic system directly or whether this occurs via the AP and PBN...
March 22, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28316564/functional-circuitry-effect-of-ventral-tegmental-area-deep-brain-stimulation-imaging-and-neurochemical-evidence-of-mesocortical-and-mesolimbic-pathway-modulation
#2
Megan L Settell, Paola Testini, Shinho Cho, Jannifer H Lee, Charles D Blaha, Hang J Jo, Kendall H Lee, Hoon-Ki Min
Background: The ventral tegmental area (VTA), containing mesolimbic and mesocortical dopaminergic neurons, is implicated in processes involving reward, addiction, reinforcement, and learning, which are associated with a variety of neuropsychiatric disorders. Electrical stimulation of the VTA or the medial forebrain bundle and its projection target the nucleus accumbens (NAc) is reported to improve depressive symptoms in patients affected by severe, treatment-resistant major depressive disorder (MDD) and depressive-like symptoms in animal models of depression...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28315693/central-glp-1-receptor-activation-modulates-cocaine-evoked-phasic-dopamine-signaling-in-the-nucleus-accumbens-core
#3
Samantha M Fortin, Mitchell F Roitman
Drugs of abuse increase the frequency and magnitude of brief (1-3s), high concentration (phasic) dopamine release events in terminal regions. These are thought to be a critical part of drug reinforcement and ultimately the development of addiction. Recently, metabolic regulatory peptides, including the satiety signal glucagon-like peptide-1 (GLP-1), have been shown to modulate cocaine reward-driven behavior and sustained dopamine levels after cocaine administration. Here, we use fast-scan cyclic voltammetry (FSCV) to explore GLP-1 receptor (GLP-1R) modulation of dynamic dopamine release in the nucleus accumbens (NAc) during cocaine administration...
March 15, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28254294/fabrication-of-highly-sensitive-gold-nanourchins-based-electrochemical-sensor-for-nanomolar-determination-of-primaquine
#4
Neeta Bachheti Thapliyal, Tirivashe Elton Chiwunze, Rajshekhar Karpoormath, Srinivasulu Cherukupalli
A gold nanourchins modified glassy carbon electrode (AuNu/GCE) was developed for the determination of antimalarial drug, primaquine (PQ). The surface of AuNu/GCE was characterized by electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and cyclic voltammetry (CV). EIS results indicated that the electron transfer process at AuNu/GCE was faster as compared to the bare electrode. The SEM and TEM image confirmed the presence and uniform dispersion of gold nanourchins on the GCE surface...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28246328/synaptic-vesicle-glycoprotein-2c-sv2c-modulates-dopamine-release-and-is-disrupted-in-parkinson-disease
#5
Amy R Dunn, Kristen A Stout, Minagi Ozawa, Kelly M Lohr, Carlie A Hoffman, Alison I Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W Michael Caudle, Gary W Miller
Members of the synaptic vesicle glycoprotein 2 (SV2) family of proteins are involved in synaptic function throughout the brain. The ubiquitously expressed SV2A has been widely implicated in epilepsy, although SV2C with its restricted basal ganglia distribution is poorly characterized. SV2C is emerging as a potentially relevant protein in Parkinson disease (PD), because it is a genetic modifier of sensitivity to l-DOPA and of nicotine neuroprotection in PD. Here we identify SV2C as a mediator of dopamine homeostasis and report that disrupted expression of SV2C within the basal ganglia is a pathological feature of PD...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28223145/rapid-induction-of-dopamine-sensitization-in-the-nucleus-accumbens-shell-induced-by-a-single-injection-of-cocaine
#6
Bryan F Singer, Myranda A Bryan, Pavlo Popov, Terry E Robinson, Brandon J Aragona
Repeated intermittent exposure to cocaine results in the neurochemical sensitization of dopamine (DA) transmission within the nucleus accumbens (NAc). Indeed, the excitability of DA neurons in the ventral tegmental area (VTA) is enhanced within hours of initial psychostimulant exposure. However, it is not known if this is accompanied by a comparably rapid change in the ability of cocaine to increase extracellular DA concentrations in the ventral striatum. To address this question we used fast-scan cyclic voltammetry (FSCV) in awake-behaving rats to measure DA responses in the NAc shell following an initial intravenous cocaine injection, and then again 2-h later...
May 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28196657/dopamine-release-in-the-nucleus-accumbens-is-altered-following-traumatic-brain-injury
#7
Yuan-Hao Chen, Eagle Yi-Kung Huang, Tung-Tai Kuo, Barry J Hoffer, Jonathan Miller, Yu-Ching Chou, Yung-Hsiao Chiang
Mild-to-severe traumatic brain injury (TBI) is frequently associated with prolonged dysfunction of reward circuitry, including motivation and salience, which suggests alterations of dopamine (DA) processing within the core and shell of the nucleus accumbens (NAC). Using fast-scan cyclic voltammetry in a rodent model of traumatic brain injury, we found that stimulus-evoked DA release is distinct in the core and shell of the NAC, with the shell being less responsive to tonic stimulation and more sensitive to the number of pulses when phasic stimulation is applied...
February 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28196418/automated-algorithm-for-detection-of-transient-adenosine-release
#8
Ryan P Borman, Ying Wang, Michael D Nguyen, Mallikarjunarao Ganesana, Scott T Lee, B Jill Venton
Spontaneous adenosine release events have been discovered in the brain that last only a few seconds. The identification of these adenosine events from fast-scan cyclic voltammetry (FSCV) data is difficult due to the random nature of adenosine release. In this study, we develop an algorithm that automatically identifies and characterizes adenosine transient features, including event time, concentration, and duration. Automating the data analysis reduces analysis time from 10 to 18 h to about 40 min per experiment...
February 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28186690/reduced-levels-of-cacna1c-attenuate-mesolimbic-dopamine-system-function
#9
Chantelle E Terrillion, David T Dao, Roger Cachope, Mary Kay Lobo, Adam C Puche, Joseph F Cheer, Todd D Gould
Genetic variation in CACNA1C, which codes for the L-type calcium channel (LTCC) Cav 1.2, is associated with clinical diagnoses of bipolar disorder, depression, and schizophrenia. Dysregulation of the mesolimbic dopamine (DA) system is linked to these syndromes and LTCCs are required for normal DAergic neurotransmission between the ventral tegmental area (VTA) and nucleus accumbens (NAc). It is unclear, however, how variations in CACNA1C genotype, and potential subsequent changes in expression levels in these regions, modify risk...
February 10, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28177213/characterization-of-optically-and-electrically-evoked-dopamine-release-in-striatal-slices-from-digenic-knock-in-mice-with-dat-driven-expression-of-channelrhodopsin
#10
Brian O'Neill, Jyoti C Patel, Margaret E Rice
Fast-scan cyclic voltammetry (FCV) is an established method to monitor increases in extracellular dopamine (DA) concentration ([DA]o) in the striatum, which is densely innervated by DA axons. Ex vivo brain slice preparations provide an opportunity to identify endogenous modulators of DA release. For these experiments, local electrical stimulation is often used to elicit release of DA, as well as other transmitters, in the striatal microcircuitry; changes in evoked increases in [DA]o after application of a pharmacological agent (e...
February 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28153284/glucose-sensing-on-graphite-screen-printed-electrode-modified-by-sparking-of-copper-nickel-alloys
#11
Daniel Riman, Konstantinos Spyrou, Alexandros E Karantzalis, Jan Hrbac, Mamas I Prodromidis
Electric spark discharge was employed as a green, fast and extremely facile method to modify disposable graphite screen-printed electrodes (SPEs) with copper, nickel and mixed copper/nickel nanoparticles (NPs) in order to be used as nonenzymatic glucose sensors. Direct SPEs-to-metal (copper, nickel or copper/nickel alloys with 25/75, 50/50 and 75/25wt% compositions) sparking at 1.2kV was conducted in the absence of any solutions under ambient conditions. Morphological characterization of the sparked surfaces was performed by scanning electron microscopy, while the chemical composition of the sparked NPs was evaluated with energy dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28127962/hitchhiker-s-guide-to-voltammetry-acute-and-chronic-electrodes-for-in-vivo-fast-scan-cyclic-voltammetry
#12
Nathan T Rodeberg, Stefan G Sandberg, Justin A Johnson, Paul E M Phillips, R Mark Wightman
Fast-scan cyclic voltammetry (FSCV) has been used for over 20 years to study rapid neurotransmission in awake and behaving animals. These experiments were first carried out with carbon-fiber microelectrodes (CFMs) encased in borosilicate glass, which can be inserted into the brain through micromanipulators and guide cannulas. More recently, chronically implantable CFMs constructed with small diameter fused-silica have been introduced. These electrodes can be affixed in the brain with minimal tissue response, which permits longitudinal measurements of neurotransmission in single recording locations during behavior...
February 9, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28071892/transient-adenosine-release-is-modulated-by-nmda-and-gabab-receptors
#13
Michael D Nguyen, Ying Wang, Mallikarjunarao Ganesana, B Jill Venton
Adenosine is a neuroprotective agent that modulates neurotransmission and is modulated by other neurotransmitters. Spontaneous, transient adenosine is a recently discovered mode of signaling where adenosine is released and cleared from the extracellular space quickly, in less than three seconds. Spontaneous adenosine release is regulated by adenosine A1 and A2a receptors, but regulation by other neurotransmitter receptors has not been studied. Here, we examined the effect of glutamate and GABA receptors on the concentration and frequency of spontaneous, transient adenosine release by measuring adenosine with fast-scan cyclic voltammetry in the rat caudate-putamen...
January 30, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28064128/a-novel-luminescence-functionalized-metal-organic-framework-nanoflowers-electrochemiluminesence-sensor-via-on-off-system
#14
Shu Zhu, Xia Lin, Peiyao Ran, Qiao Xia, Chengcheng Yang, Jiao Ma, Yingzi Fu
A novel solid-state electrochemiluminesence (ECL) "on-off" switch system for highly sensitive detection of tryptophan based on the luminescence-functionalized ruthenium metal-organic framework (Ru-MOF) nanoflowers and CdS quantum dots (CdSQDs) was described. Ru-MOF nanoflowers were prepared by a one-step solvothermal method at low temperature and characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared (FTIR) spectra and fluorescence (FL) spectra...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28044445/background-signal-as-an-in-situ-predictor-of-dopamine-oxidation-potential-improving-interpretation-of-fast-scan-cyclic-voltammetry-data
#15
Carl J Meunier, James G Roberts, Gregory S McCarty, Leslie A Sombers
Background-subtracted fast-scan cyclic voltammetry (FSCV) has emerged as a powerful analytical technique for monitoring subsecond molecular fluctuations in live brain tissue. Despite increasing utilization of FSCV, efforts to improve the accuracy of quantification have been limited due to the complexity of the technique and the dynamic recording environment. It is clear that variable electrode performance renders calibration necessary for accurate quantification; however, the nature of in vivo measurements can make conventional postcalibration difficult, or even impossible...
January 24, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28038309/diazepam-inhibits-electrically-evoked-and-tonic-dopamine-release-in-the-nucleus-accumbens-and-reverses-the-effect-of-amphetamine
#16
Alexander Gomez-A, Amanda M Fiorenza, Suelen L Boschen, Adam H Sugi, Danielle Beckman, Sergio T Ferreira, Kendall Lee, Charles D Blaha, Claudio Da Cunha
Diazepam is a benzodiazepine receptor agonist with anxiolytic and addictive properties. Although most drugs of abuse increase the level of release of dopamine in the nucleus accumbens, here we show that diazepam not only causes the opposite effect but also prevents amphetamine from enhancing dopamine release. We used 20 min sampling in vivo microdialysis and subsecond fast-scan cyclic voltammetry recordings at carbon-fiber microelectrodes to show that diazepam caused a dose-dependent decrease in the level of tonic and electrically evoked dopamine release in the nucleus accumbens of urethane-anesthetized adult male Swiss mice...
February 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28013000/galanin-contributes-to-monoaminergic-dysfunction-and-to-dependent-neurobehavioral-comorbidities-of-epilepsy
#17
Jesus-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarati
Status epilepticus (SE) in rats, along with chronic epilepsy, leads to the development of behavioral impairments resembling depressive disorder and/or attention deficit/hyperactivity disorder (ADHD), thus reflecting respective comorbidities in epilepsy patients. Suppressed neurotransmitter tone in the raphe nucleus (RN)-prefrontal cortex (PFC) serotonergic pathway and in the locus coeruleus (LC)-PFC noradrenergic pathway underlies depressive- and impulsive-like behavioral deficits respectively. We examined possible mechanisms leading to the monoamine dysfunction in brainstem efferents, namely modulatory effects of the neuropeptide galanin on serotonin (5-HT) and norepinephrine (NE) signaling...
March 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27984698/simultaneous-voltammetric-measurements-of-glucose-and-dopamine-demonstrate-the-coupling-of-glucose-availability-with-increased-metabolic-demand-in-the-rat-striatum
#18
Samantha K Smith, Christie A Lee, Matthew E Dausch, Brian M Horman, Heather B Patisaul, Gregory S McCarty, Leslie A Sombers
Cerebral blood flow ensures delivery of nutrients, such as glucose, to brain sites with increased metabolic demand. However, little is known about rapid glucose dynamics at discrete locations during neuronal activation in vivo. Acute exposure to many substances of abuse elicits dopamine release and neuronal activation in the striatum; however, the concomitant changes in striatal glucose remain largely unknown. Recent developments have combined fast-scan cyclic voltammetry with glucose oxidase enzyme modified carbon-fiber microelectrodes to enable the measurement of glucose dynamics with subsecond temporal resolution in the mammalian brain...
January 17, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27968717/glycated-hemoglobin-biosensing-integration-formed-on-au-nanoparticle-dotted-tubular-tio2-nanoarray
#19
Utkarsh Jain, Anamika Singh, Naresh Kumar Kuchhal, Nidhi Chauhan
Excessive glucose present in the blood of diabetic patients binds with the hemoglobin of red blood cells resulting in the formation of glycated hemoglobin (HbA1c). Measurement of HbA1c levels may help in identifying the efficacy of the ongoing treatment and hence provide a better control over the disease. In the present study, we have synthesized a sensitive and stable scaffold, which consists of Au nanoparticles (GNPs)-dotted tubular TiO2, for the construction of an electrochemical HbA1c biosensor. 12-phosphotungstic acid has been used as a reducer after depositing well-dispersed GNPs on TiO2 nanotubes (TiO2 NTs) and an electron mediator by accelerating the electron transfer between the conductor and protein...
November 16, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27966885/high-fat-diet-induced-deficits-in-dopamine-terminal-function-are-reversed-by-restoring-insulin-signaling
#20
Steve C Fordahl, Sara R Jones
Systemically released insulin crosses the blood-brain barrier and binds to insulin receptors on several neural cell types, including dopaminergic neurons. Insulin has been shown to decrease dopamine neuron firing in the ventral tegmental area (VTA), but potentiate release and reuptake at dopamine terminals in the nucleus accumbens (NAc). Here we show that prolonged consumption of a high fat diet blocks insulin's effects in the NAc, but insulin's effects are restored by inhibiting protein tyrosine phosphatase 1B, which supports insulin receptor signaling...
February 15, 2017: ACS Chemical Neuroscience
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