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https://www.readbyqxmd.com/read/28106808/anti-fatigue-effects-of-the-unique-polysaccharide-marker-of-dendrobium-officinale-on-balb-c-mice
#1
Wei Wei, Zhi-Peng Li, Tong Zhu, Hau-Yee Fung, Tin-Long Wong, Xin Wen, Dik-Lung Ma, Chung-Hang Leung, Quan-Bin Han
Dendrobium officinale extract shows potent anti-fatigue effects; however, the active substance responsible for these effects remains undetermined. A glucomannan with a huge molecular size of 730 kDa, called DOP, was identified as the unique authentication marker of this expensive herb. DOP exhibited immunomodulating effects on macrophages and lymphocytes in our previous study. Clinical reports also showed that people with fatigue syndrome have a disturbed immune system. Because DOP is the unique and dominant component of D...
January 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106305/diversity-oriented-peptide-stapling-a-third-generation-cuaac-stapling-and-functionalisation-strategy
#2
Thu Tran Phuong, Christian Ørnbøl Larsen, Tobias Røndbjerg, Martina De Foresta, Micha Ben Achim Kunze, Ales Marek, Jacob Hartvig Løper, Lotte-Emilie Boyhus, Astrid Knuhtsen, Kresten Lindorff-Larsen, Daniel Sejer Pedersen
The introduction of macrocyclic constraints in peptides (peptide stapling) is an important tool within peptide medicinal chemistry for stabilising and pre-organising peptides in a desired conformation. In recent years, the copper-catalysed azide-alkyne cycloaddition (CuAAC) has emerged as a powerful method for peptide stapling. However, to date CuAAC stapling has not provided a simple method for obtaining peptides that are easily diversified further. In the present study, we report a new diversity-oriented peptide stapling (DOPS) methodology based on CuAAC chemistry...
January 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28087277/identification-of-ubact-a-ubiquitin-like-protein-along-with-other-homologous-components-of-a-conjugation-system-and-the-proteasome-in-different-gram-negative-bacteria
#3
Gilad Lehmann, Ronald G Udasin, Ido Livneh, Aaron Ciechanover
Systems analogous to the eukaryotic ubiquitin-proteasome system have been previously identified in Archaea, and Actinobacteria (gram-positive), but not in gram-negative bacteria. Here, we report the bioinformatic identification of a novel prokaryotic ubiquitin-like protein, which we name UBact. The phyletic distribution of UBact covers at least five gram-negative bacterial phyla, including Nitrospirae, Armatimonadetes, Verrucomicroba, Nitrospinae, and Planctomycetes. Additionally, it was identified in seven candidate (uncultured) phyla and one Archaeon...
January 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28069393/surface-enhanced-raman-spectroscopy-of-self-assembled-layers-of-lipid-molecules-on-nanostructured-au-and-ag-substrates
#4
Nora Slekiene, Lina Ramanauskaite, Valentinas Snitka
In this work surface enhanced Raman spectroscopy (SERS) has been used for the investigation of the self-assembled layers of lipid molecules (SALLMs) deposited on the nanostructured Au and Ag surfaces. The SALLMs were prepared from one part of 1,2-dioleoyl-sn-glycero-3-phospho-l-serine (DOPS) and four parts of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipids. The synthesis of Au and Ag SERS substrates was based on the direct gold and silver ions reduction onto HF etched silicon wafers. Au SERS substrates were not suitable for the formation of SALLMs because of the inappropriate contact angle of surface...
January 6, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28049031/the-efficacy-of-dynorphin-fragments-at-the-%C3%AE%C2%BA-%C3%AE-and-%C3%AE-opioid-receptor-in-transfected-hek-cells-and-in-an-animal-model-of-unilateral-peripheral-inflammation
#5
M Morgan, A Heffernan, F Benhabib, S Wagner, A K Hewavitharana, P N Shaw, P J Cabot
Dynorphin 1-17 is an endogenous peptide that is released at sites of inflammation by leukocytes, binding preferentially to κ-opioid receptors (KOP) to mediate nociception. We have previously shown that dynorphin 1-17 is rapidly biotransformed to smaller peptide fragments in inflamed tissue homogenate. This study aimed to determine the efficacy and potency of selected dynorphin fragments produced in an inflamed environment at the KOP, μ and δ-opioid receptors (MOP and DOP respectively) and in a model of inflammatory pain...
December 31, 2016: Peptides
https://www.readbyqxmd.com/read/27995824/not-all-dietary-diversity-scores-can-legitimately-be-interpreted-as-proxies-of-diet-quality
#6
Eric O Verger, Marie-Claude Dop, Yves Martin-Prével
No abstract text is available yet for this article.
December 20, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27993475/in-vitro-and-in-silico-investigations-of-the-binary-mixture-toxicity-of-phthalate-esters-and-cadmium-ii-to-vibrio-qinghaiensis-sp-q67
#7
Keke Ding, Liping Lu, Jiaying Wang, Jingpeng Wang, Minqiang Zhou, Cunwu Zheng, Jinsong Liu, Chunlong Zhang, Shulin Zhuang
Phthalate esters (PAEs) are widely used as plasticizers and have become one of the emerging contaminants with an increasing public concern. The residues of PAEs frequently co-exist with heavy metals such as cadmium (Cd) in waters; however, their joint ecotoxicity remains largely unknown. We herein investigated the single and joint toxicity of commonly used PAEs and Cd using freshwater luminescent bacteria Vibrio qinghaiensis sp.-Q67. The median effective concentration (EC50) of benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), diethyl phthalate (DEP), dimethyl phthalate (DMP), diisooctyl phthalate (DIOP) and di-n-octyl phthalate (DOP) were determined to be in the range from 134...
December 16, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27966489/reserpine-requires-the-d2-type-receptor-dop-3-and-the-exoribonuclease-eri-1-to-extend-the-lifespan-in-c-elegans
#8
Kopal Saharia, Ranjeet Kumar, Kuldeep Gupta, Shrilekha Mishra, Jamuna R Subramaniam
Lifespan extension is an all systems encompassing event. Involvement of reduced insulin/IGF1 signalling is well worked out, first in the model organism Caenorhbaditis elegans followed by other systems including humans. But the role of neuronal component in lifespan extension is not well understood due to the refractory nature of neurons to small RNA interference (sRNAi) in C. elegans. Earlier, we have demonstrated that an antihypertensive drug, reserpine, extends lifespan through modulation of neurotransmitter release, especially, acetylcholine, in C...
December 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27858112/effects-of-sabbagh-universal-spring-2-fixed-functional-appliance-on-class-ii-1-patients-at-their-postpubertal-peak-growth-period-compared-with-the-extraction-method-a-randomized-clinical-trial
#9
Siamak Hemmatpour, Ali Mokhtar, Vahid Rakhshan
OBJECTIVE: The aim of this study was to evaluate the therapeutic effects of the Sabbagh Universal Spring 2 (SUS 2) fixed functional appliance compared to the premolar extraction method in correcting class II/1 malocclusion in patients who had passed their peak of postpubertal growth (stages 4-6 of Cervical Vertebral Maturation Index). METHODS: In all, 40 class II/1 patients were randomized to receive SUS 2 application (7 males, 13 females, age 15.75 ± 1.02 years) or maxillary premolar extraction (8 males, 12 females, age 15...
January 2017: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27836348/assessing-the-concentration-of-phthalate-esters-paes-and-bisphenol-a-bpa-and-the-genotoxic-potential-of-treated-wastewater-final-effluent-in-saudi-arabia
#10
Iman Al-Saleh, Rola Elkhatib, Tahreer Al-Rajoudi, Ghofran Al-Qudaihi
Plasticizers such as phthalate esters (PAEs) and bisphenol A (BPA) are highly persistent organic pollutants that tend to bio-accumulate in humans through the soil-plant-animal food chain. Some studies have reported the potential carcinogenic and teratogenic effects in addition to their estrogenic activities. Water resources are scarce in Saudi Arabia, and several wastewater treatment plants (WTPs) have been constructed for agricultural and industrial use. This study was designed to: (1) measure the concentrations of BPA and six PAEs, dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butyl benzyl phthalate (BBP), bis (2-ethylhexyl) phthalate (DEHP) and dioctyl phthalate (DOP), in secondary- and tertiary-treated wastewater collected from five WTPs in three Saudi cities for four to five weeks and (2) test their potential genotoxicity...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27835853/fluxes-seasonal-patterns-and-sources-of-various-nutrient-species-nitrogen-phosphorus-and-silicon-in-atmospheric-wet-deposition-and-their-ecological-effects-on-jiaozhou-bay-north-china
#11
Jianwei Xing, Jinming Song, Huamao Yuan, Xuegang Li, Ning Li, Liqin Duan, Xuming Kang, Qidong Wang
Atmospheric wet deposition (AWD) is an important pathway for anthropogenic and natural pollutants entering aquatic ecosystems. However, the study on the magnitudes and ecological effects of AWD of various nutrient species (nitrogen, phosphorus and silicon) on Jiaozhou Bay is scarce. To address these issues, in this study, wet deposition samples were collected at a coastline site along Jiaozhou Bay from June 2015 to May 2016. Dissolved inorganic nitrogen (DIN, including NH4-N, NO3-N and NO2-N), dissolved organic nitrogen (DON), dissolved inorganic phosphorus (DIP, i...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27833485/toward-competency-based-curriculum-application-of-workplace-based-assessment-tools-in-the-national-saudi-arabian-anesthesia-training-program
#12
Ama Boker
BACKGROUND: The anesthesia training program of the Saudi Commission for health specialties has introduced a developed competency-based anesthesia residency program starting from 2015 with the utilization of the workplace-based assessment (WBA) tools, namely mini-clinical exercises (mini-CEX), direct observation of procedural skills (DOPS), and case-based discussion (CBD). OBJECTIVES: This work aimed to describe the process of development of anesthesia-specific list of mini-CEX, DOPS, and CBD tools within the Saudi Arabian Anesthesia Training Programs...
October 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/27832372/isolation-and-application-of-p-genome-specific-dna-sequences-of-agropyron-gaertn-in-triticeae
#13
Haiming Han, Weihua Liu, Yuqing Lu, Jinpeng Zhang, Xinming Yang, Xiuquan Li, Zanmin Hu, Lihui Li
Different types of P genome sequences and markers were developed, which could be used to analyze the evolution of P genome in Triticeae and identify precisely wheat- A. cristatum introgression lines. P genome of Agropyron Gaertn. plays an important role in Triticeae and could provide many desirable genes conferring high yield, disease resistance, and stress tolerance for wheat genetic improvement. Therefore, it is significant to develop specific sequences and functional markers of P genome. In this study, 126 sequences were isolated from the degenerate oligonucleotide primed-polymerase chain reaction (DOP-PCR) products of microdissected chromosome 6PS...
November 10, 2016: Planta
https://www.readbyqxmd.com/read/27828310/tunable-scalar-solitons-from-a-polarization-maintaining-mode-locked-fiber-laser-using-carbon-nanotube-and-chirped-fiber-bragg-grating
#14
Jie Wang, Yaxi Yan, A Ping Zhang, Bo Wu, Yonghang Shen, Hwa-Yaw Tam
Generation of tunable scalar solitons from a polarization-maintaining (PM) mode-locked fiber laser is presented. A single-walled carbon nanotube (SWCNT) absorber is used for self-started mode locking. A chirped fiber Bragg grating (CFBG) mounted on a cantilever is employed as a tunable all-fiber filter. Mode-locked solitons are obtained with typical pulse duration of ~6.94 ps and repetition rate of 28.94 MHz. Linearly polarized laser emission is characterized with degree of polarization (DOP) of ~99.5%. The wavelength of the emitted scalar soliton can be continuously tuned through adjusting the CFBG, while maintaining the polarization stability...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27753920/os-04-04-antihypertensive-effect-of-milk-derivative-tripeptides-randomized-double-blind-placebo-controlled-study-on-the-effects-of-grana-padano-cheese-dop-in-hypertensive-patients
#15
Giuseppe Crippa, Dorjan Zabzuni, Elena Bravi, Filippo Rossi
OBJECTIVE: Present data refers to a randomized, double-blind, placebo-controlled, cross-over study in which 30 mild-moderate hypertensive patients, received a dietary integration with Grana Padano DOP cheese to evaluate blood pressure (BP) changes.Cow-milk fermentation induced by Lactobacillus helveticus produces peptides with sustained ACE inhibitory activity, mainly dues to 2 tripeptides (valyl-prolyl-proline and isoleucil-prolyl-proline) that have shown to lower blood pressure (BP) in experimental animals and in humans...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27751964/altered-expression-of-glial-markers-chemokines-and-opioid-receptors-in-the-spinal-cord-of-type-2-diabetic-monkeys
#16
Norikazu Kiguchi, Huiping Ding, Christopher M Peters, Nancy D Kock, Shiroh Kishioka, J Mark Cline, Janice D Wagner, Mei-Chuan Ko
Neuroinflammation is a pathological condition that underlies diabetes and affects sensory processing. Given the high prevalence of pain in diabetic patients and crosstalk between chemokines and opioids, it is pivotal to know whether neuroinflammation-associated mediators are dysregulated in the central nervous system of diabetic primates. Therefore, the aim of this study was to investigate whether mRNA expression levels of glial markers, chemokines, and opioid receptors are altered in the spinal cord and thalamus of naturally occurring type 2 diabetic monkeys (n=7) compared with age-matched non-diabetic monkeys (n=6)...
January 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27747105/restoring-spinal-noradrenergic-inhibitory-tone-attenuates-pain-hypersensitivity-in-a-rat-model-of-parkinson-s-disease
#17
Lei-Fang Cao, Xiao-Yan Peng, Ya Huang, Bing Wang, Feng-Ming Zhou, Ruo-Xiao Cheng, Li-Hua Chen, Wei-Feng Luo, Tong Liu
In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu). PD rats developed thermal and mechanical hypersensitivity at the 4th week after surgery. HPLC analysis showed that NE content, but not dopamine or 5-HT, significantly decreased in lumbar spinal cord in PD rats. Additional noradrenergic depletion by injection of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) aggravated pain hypersensitivity in PD rats...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27726035/phylotype-dynamics-of-bacterial-p-utilization-genes-in-microbialites-and-bacterioplankton-of-a-monomictic-endorheic-lake
#18
Patricia M Valdespino-Castillo, Rocío J Alcántara-Hernández, Martín Merino-Ibarra, Javier Alcocer, Miroslav Macek, Octavio A Moreno-Guillén, Luisa I Falcón
Microbes can modulate ecosystem function since they harbor a vast genetic potential for biogeochemical cycling. The spatial and temporal dynamics of this genetic diversity should be acknowledged to establish a link between ecosystem function and community structure. In this study, we analyzed the genetic diversity of bacterial phosphorus utilization genes in two microbial assemblages, microbialites and bacterioplankton of Lake Alchichica, a semiclosed (i.e., endorheic) system with marked seasonality that varies in nutrient conditions, temperature, dissolved oxygen, and water column stability...
October 10, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27698674/diabetic-osteoporosis-a-review-of-its-traditional-chinese-medicinal-use-and-clinical-and-preclinical-research
#19
Rufeng Ma, Ruyuan Zhu, Lili Wang, Yubo Guo, Chenyue Liu, Haixia Liu, Fengwei Liu, Hongjun Li, Yu Li, Min Fu, Dongwei Zhang
Aim. The incidence of diabetic osteoporosis (DOP) is increasing due to lack of effective management over the past few decades. This review aims to summarize traditional Chinese medicine (TCM) suitability in the pathogenesis and clinical and preclinical management of DOP. Methods. Literature sources used were from Medline (Pubmed), CNKI (China Knowledge Resource Integrated Database), and CSTJ (China Science and Technology Journal Database) online databases. For the consultation, keywords such as diabetic osteoporosis (DOP), TCM, clinical study, animal experiment, toxicity, and research progress were used in various combinations...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27690147/phthalate-exposure-flavonoid-consumption-and-breast-cancer-risk-among-mexican-women
#20
Ángel Mérida-Ortega, César Hernández-Alcaraz, Raúl U Hernández-Ramírez, Angélica García-Martínez, Belem Trejo-Valdivia, Aarón Salinas-Rodríguez, Katherine Svensson, Mariano E Cebrián, Francisco Franco-Marina, Lizbeth López-Carrillo
OBJECTIVE: To evaluate if selected phthalate exposure and flavonoid intake interact on breast cancer (BC) risk. MATERIAL AND METHODS: Interviews and urine samples were obtained from 233 women with histologically confirmed BC and 221 healthy controls matched by age and place of residence, from various states of northern Mexico. Urinary metabolites concentrations of diethyl phthalate (DEP), butyl benzyl phthalate (BBzP) and dioctyl phthalate (DOP) were determined by solid-phase extraction coupled with high-performance liquid chromatography/isotope dilution/tandem mass spectrometry...
September 27, 2016: Environment International
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