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Giuseppe Crippa, Dorjan Zabzuni, Elena Bravi, Filippo Rossi
OBJECTIVE: Present data refers to a randomized, double-blind, placebo-controlled, cross-over study in which 30 mild-moderate hypertensive patients, received a dietary integration with Grana Padano DOP cheese to evaluate blood pressure (BP) changes.Cow-milk fermentation induced by Lactobacillus helveticus produces peptides with sustained ACE inhibitory activity, mainly dues to 2 tripeptides (valyl-prolyl-proline and isoleucil-prolyl-proline) that have shown to lower blood pressure (BP) in experimental animals and in humans...
September 2016: Journal of Hypertension
Norikazu Kiguchi, Huiping Ding, Christopher M Peters, Nancy D Kock, Shiroh Kishioka, J Mark Cline, Janice D Wagner, Mei-Chuan Ko
Neuroinflammation is a pathological condition that underlies diabetes and affects sensory processing. Given the high prevalence of pain in diabetic patients and crosstalk between chemokines and opioids, it is pivotal to know whether neuroinflammation-associated mediators are dysregulated in the central nervous system of diabetic primates. Therefore, the aim of this study was to investigate whether mRNA expression levels of glial markers, chemokines, and opioid receptors are altered in the spinal cord and thalamus of naturally occurring type 2 diabetic monkeys (n=7) compared with age-matched non-diabetic monkeys (n=6)...
October 14, 2016: Biochimica et Biophysica Acta
Lei-Fang Cao, Xiao-Yan Peng, Ya Huang, Bing Wang, Feng-Ming Zhou, Ruo-Xiao Cheng, Li-Hua Chen, Wei-Feng Luo, Tong Liu
In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu). PD rats developed thermal and mechanical hypersensitivity at the 4th week after surgery. HPLC analysis showed that NE content, but not dopamine or 5-HT, significantly decreased in lumbar spinal cord in PD rats. Additional noradrenergic depletion by injection of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) aggravated pain hypersensitivity in PD rats...
2016: Neural Plasticity
Patricia M Valdespino-Castillo, Rocío J Alcántara-Hernández, Martín Merino-Ibarra, Javier Alcocer, Miroslav Macek, Octavio A Moreno-Guillén, Luisa I Falcón
Microbes can modulate ecosystem function since they harbor a vast genetic potential for biogeochemical cycling. The spatial and temporal dynamics of this genetic diversity should be acknowledged to establish a link between ecosystem function and community structure. In this study, we analyzed the genetic diversity of bacterial phosphorus utilization genes in two microbial assemblages, microbialites and bacterioplankton of Lake Alchichica, a semiclosed (i.e., endorheic) system with marked seasonality that varies in nutrient conditions, temperature, dissolved oxygen, and water column stability...
October 10, 2016: Microbial Ecology
Rufeng Ma, Ruyuan Zhu, Lili Wang, Yubo Guo, Chenyue Liu, Haixia Liu, Fengwei Liu, Hongjun Li, Yu Li, Min Fu, Dongwei Zhang
Aim. The incidence of diabetic osteoporosis (DOP) is increasing due to lack of effective management over the past few decades. This review aims to summarize traditional Chinese medicine (TCM) suitability in the pathogenesis and clinical and preclinical management of DOP. Methods. Literature sources used were from Medline (Pubmed), CNKI (China Knowledge Resource Integrated Database), and CSTJ (China Science and Technology Journal Database) online databases. For the consultation, keywords such as diabetic osteoporosis (DOP), TCM, clinical study, animal experiment, toxicity, and research progress were used in various combinations...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Ángel Mérida-Ortega, César Hernández-Alcaraz, Raúl U Hernández-Ramírez, Angélica García-Martínez, Belem Trejo-Valdivia, Aarón Salinas-Rodríguez, Katherine Svensson, Mariano E Cebrián, Francisco Franco-Marina, Lizbeth López-Carrillo
OBJECTIVE: To evaluate if selected phthalate exposure and flavonoid intake interact on breast cancer (BC) risk. MATERIAL AND METHODS: Interviews and urine samples were obtained from 233 women with histologically confirmed BC and 221 healthy controls matched by age and place of residence, from various states of northern Mexico. Urinary metabolites concentrations of diethyl phthalate (DEP), butyl benzyl phthalate (BBzP) and dioctyl phthalate (DOP) were determined by solid-phase extraction coupled with high-performance liquid chromatography/isotope dilution/tandem mass spectrometry...
September 27, 2016: Environment International
Nasr Y A Hemdan, Cynthia Weigel, Christina-Maria Reimann, Markus H Gräler
Sepsis is a systemic inflammatory response to pathogens and a leading cause of hospital related mortality worldwide. Sphingosine 1-phosphate (S1P) regulates multiple cellular processes potentially involved in the pathogenesis of sepsis, including antigen presentation, lymphocyte egress, and maintenance of vascular integrity. We thus explored the impact of manipulating S1P signaling in experimental polymicrobial sepsis in mice. Administration of 4-deoxypyridoxine (DOP), an inhibitor of the S1P-degrading enzyme S1P-lyase, or of the sphingosine analogue FTY720 that serves as an S1P receptor agonist after phosphorylation ameliorated morbidity, improved recovery from sepsis in surviving mice, and reduced sepsis-elicited hypothermia and body weight loss...
September 29, 2016: European Journal of Immunology
Lingxiao Ren, Peifang Wang, Chao Wang, Juan Chen, Jun Hou, Jin Qian
Phosphorus (P) plays a critical role in algal growth; therefore, a better understanding of P availability is essential to control harmful algal blooms. Three algae species, Microcystis aeruginosa, Chlorella pyrenoidosa, and Pseudokirchneriella subcapitata, were mono-cultured and co-cultured on three types of P substrates, dissolved inorganic P (DIP), phosphomonoesters glucose-6-phosphate (G-6-P) and β-glycerol phosphate (β-glycerol-P), and phosphonate (glyphosate), to explore their growth and P utilization...
September 22, 2016: Environmental Pollution
Xin-Li Song, Yue Chen, Jin-Peng Yuan, Yu-Jun Qin, Ru-Song Zhao, Xiao Wang
Multiwalled carbon nanotubes (MWCNTs) on polystyrene (PS) microspheres have been designed and prepared by layer-by-layer assembly via electrostatic interaction. MWCNTs@PS was characterized by scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The new materials were employed as a novel solid-phase microextraction (SPME) coating to enrich trace level of phthalate acid esters (PAEs) in water samples. Five PAEs, di-n-butyl phthalate (DBP), benzyl butyl phthalate (BBP), di-2-ethylhexyl adipate (DEHA), di-2-ethylhexyl phthalate (DEHP) and di-n-octyl phthalate (DOP), were studied in this work...
October 14, 2016: Journal of Chromatography. A
Giuseppe Crippa, Dorjan Zabzuni, Elena Bravi, Filippo Rossi
OBJECTIVE: Present data refers to a randomized, double-blind, placebo-controlled, cross-over study in which 30 mild-moderate hypertensive patients, received a dietary integration with Grana Padano DOP cheese to evaluate blood pressure (BP) changes.Cow-milk fermentation induced by Lactobacillus helveticus produces peptides with sustained ACE inhibitory activity, mainly dues to 2 tripeptides (valyl-prolyl-proline and isoleucil-prolyl-proline) that have shown to lower blood pressure (BP) in experimental animals and in humans...
September 2016: Journal of Hypertension
Evan L Ardiel, Andrew C Giles, Alex J Yu, Theodore H Lindsay, Shawn R Lockery, Catharine H Rankin
Habituation is a highly conserved phenomenon that remains poorly understood at the molecular level. Invertebrate model systems, like Caenorhabditis elegans, can be a powerful tool for investigating this fundamental process. Here we established a high-throughput learning assay that used real-time computer vision software for behavioral tracking and optogenetics for stimulation of the C. elegans polymodal nociceptor, ASH. Photoactivation of ASH with ChR2 elicited backward locomotion and repetitive stimulation altered aspects of the response in a manner consistent with habituation...
October 2016: Learning & Memory
Sailas Benjamin, Naofumi Kamimura, Kenji Takahashi, Eiji Masai
This study provides physical and analytical evidences for the efficient utilization of most of the commercially available phthalate diesters by Achromobacter denitrificans SP1, coupled with the demonstration of a plausible degradation pathway. We tested 17 phthalate diesters [viz., ditridecyl phthalate, diisodecyl phthalate (DIDP), di(2-ethylhexyl)phthalate (DEHP), di-n-octyl phthalate (DOP), bis(2-ethylhexyl)isophthalate (BEIP), dihexyl phthalate (DHP), dibutyl phthalate (DBP), dicyclohexyl phthalate (DCHP), diphenyl phthalate (DPP), benzyl butyl phthalate (BBP), diamyl phthalate (DAmP), diisobutyl phthalate, dipropyl phthalate, dially phthalate (DAlP), diethyl phthalate, diethyl terephthalate and dimethyl phthalate (DMP)], and their major degradation products for the degradation efficiency of A...
September 8, 2016: Ecotoxicology and Environmental Safety
Marcus K Dymond, Richard J Gillams, Duncan J Parker, Jamie Burrell, Ana Labrador, Tommy Nylander, George S Attard
Recently we reported a method for estimating the spontaneous curvatures of lipids from temperature-dependent changes in the lattice parameter of inverse hexagonal liquid crystal phases of binary lipid mixtures. This method makes use of 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine (DOPE) as a host lipid, which preferentially forms an inverse hexagonal phase to which a guest lipid of unknown spontaneous curvature is added. The lattice parameters of these binary lipid mixtures are determined by small-angle X-ray diffraction at a range of temperatures and the spontaneous curvature of the guest lipid is determined from these data...
October 4, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Thangarathinam Kumar, Mohandass Ramya, S J Arockiasamy Xavier
Stress degradation studies using high-performance liquid chromatography (HPLC) was performed and validated for Droxidopa (L-DOPS). Droxidopa was susceptible to acid hydrolysis (0.1 N HCl), alkaline hydrolysis (0.15 N NaOH) and thermal degradation (105°C). It was found to be resistant to white light, oxidation and UV light exposure (72 h). The thermal, acid and alkali degradation impurities were detected with the retention time (RT) of 12.7, 19.25 and 22.95 min. Our HPLC method detected process impurities (2R,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid (Impurity H), N-Hydroxypthalimide (Impurity N), (2R,3S)-2-amino-3-(benzo[d][1,3]dioxol-5-yl)-3-hydroxypropionic acid (Impurity L) and L-threo n-phthaloyl-3-(3, 4-dihydroxyphenyl)-serine (Intermediate) with RTs of 3...
September 6, 2016: Journal of Chromatographic Science
M O Moses, B M Duduyemi
Sports participation has been adjudged to enhance healthy living. This study described anthropometric andphysiological (A-P) profiles of university athletes based on types of sports (ToS) and duration (in years) of participation(DoP). One hundred and twenty-nine athletes (69 males, 60 females), aged l5-36, who had played averagely for5.78±0.29years, from nine games and preparing for Ghana University Sports Association (GUSA) 2014 participated in thestudy. Ex-post facto research design was adopted. Data on ToS, DoP, age, height, weight, body mass index, waist and hipcircumference, body fat and water, blood pressure and heart rate were collected, entered into SPSS Data Editor 17...
2016: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
Chih-Chun Mei, Fu-Ying Lee, Hwey-Chin Yeh
OBJECTIVE: To evaluate patients' pain perception following periodontal or implant surgery and to explore risk factors associated with post-surgical pain. MATERIALS AND METHODS: Patients undergoing periodontal or implant surgery were recruited. Post-surgical pain perception was evaluated by a numeric rating scale (NRS, 1 to 10) after one week. Self-reported durations of pain (DOP) and swelling (DOS), and consumption of prescriptions were also recorded. Demographic and surgical variables were compared between the groups of mild (MP) and moderate-to-severe post-surgical pain (SP)...
August 24, 2016: Journal of Clinical Periodontology
Allison Anjos, Vilma Loreto, Diogo C Cabral-de-Mello
B chromosomes occur in approximately 15% of eukaryotes and are usually heterochromatic and rich in repetitive DNAs. Here we describe characteristics of a B chromosome in the grasshopper Eumastusia koebelei koebelei (Rehn, 1909) through classical cytogenetic methods and mapping of some repetitive DNAs, including multigene families, telomeric repeats and a DNA fraction enriched with repetitive DNAs obtained from DOP-PCR. Eumastusia koebelei koebelei presented 2n=23, X0 and, in one individual, two copies of the same variant of a B chromosome were noticed, which are associated during meiosis...
2016: Comparative Cytogenetics
Matjaž Špan, Gregor Geršak, Sandrine C Millasseau, Marko Meža, Andrej Košir
In occidental countries, peripheral arterial disease (PAD) is an important health issue; however, most subjects are asymptomatic (~50%) and therefore undiagnosed and untreated. Current guidelines recommend screening for PAD in primary care setting using ankle brachial index (ABI) in all patients with cardiovascular risks. This is, however, not performed strictly because the standard Doppler method is cumbersome and time-consuming. Here, we evaluate the accuracy and reproducibility of ABI measurements obtained by an improved automated oscillometric device, the MESI ABPI MD(®) device, and the standard Doppler method...
2016: Vascular Health and Risk Management
Xiou Cao, Alejandro Aballay
The innate immune system is the front line of host defense against microbial infections, but its rapid and uncontrolled activation elicits microbicidal mechanisms that have deleterious effects [1, 2]. Increasing evidence indicates that the metazoan nervous system, which responds to stimuli originating from both the internal and the external environment, functions as a modulatory apparatus that controls not only microbial killing pathways but also cellular homeostatic mechanisms [3-5]. Here we report that dopamine signaling controls innate immune responses through a D1-like dopamine receptor, DOP-4, in Caenorhabditis elegans...
September 12, 2016: Current Biology: CB
Frantseska-Maria Pellera, Emmanouil Pasparakis, Evangelos Gidarakos
The scope of this study is to evaluate the use of laboratory-scale landfill-bioreactors, operated consecutively under anaerobic and aerobic conditions, for the combined treatment of the organic fraction of municipal solid waste (OFMSW) with two different co-substrates of lignocellulosic nature, namely green waste (GW) and dried olive pomace (DOP). According to the results such a system would represent a promising option for eventual larger scale applications. Similar variation patterns among bioreactors indicate a relatively defined sequence of processes...
October 2016: Waste Management
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