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https://www.readbyqxmd.com/read/29649507/effects-of-anthraquinones-from-cassia-occidentalis-l-on-ovalbumin-induced-airways-inflammation-in-a-mouse-model-of-allergic-asthma
#1
Wenhao Xu, Meiqun Hu, Qihong Zhang, Jingbo Yu, Weike Su
ETHNOPHARMACOLOGICAL RELEVANCE: Cassia occidentalis Linn. is a traditional ayruvedic edible shrub containing anthraquinones (AQs) as the principle active constituents. In folk medicine, it has a variety of uses including treatment of whooping cough ('pertussis') and inflammatory diseases. Despite these applications, limited data are available to validate the effects of C. occidentalis AQs on airways inflammation in asthma. AIM OF THE STUDY: To explore the anti-inflammatory potential of AQs extracted from C...
April 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29616584/trends-and-costs-of-pertussis-hospitalizations-in-portugal-2000-to-2015-from-0-to-95-years-old
#2
Sara Melo Oliveira, Manuel Gonçalves-Pinho, Alberto Freitas, Hercília Guimarães, Inês Azevedo
BACKGROUND: Pertussis has caused several outbreaks and concern worldwide. Despite high vaccination coverage, people of all ages are still affected with significant morbidity and mortality. We aimed to analyse all pertussis hospitalizations in Portugal to help to delineate preventive policies. METHODS: Data were collected from a Portuguese administrative database, which contains all registered hospitalizations in mainland Portugal. Cases were identified using the ICD-9-CM code 033...
April 4, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29601940/novel-intranasal-pertussis-vaccine-based-on-bacterium-like-particles-as-a-mucosal-adjuvant
#3
Wei Shi, Yiming Kou, Hao Jiang, Feng Gao, Wei Kong, Weiheng Su, Fei Xu, Chunlai Jiang
Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the present study, bacterium-like particles (BLPs) were adopted as a mucosal adjuvant for an i.n. pertussis vaccine and evaluated on the ability to induce serum and mucosal antibodies as well as potency against i...
March 27, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29599819/the-new-who-decision-making-framework-on-vaccine-use-in-acute-humanitarian-emergencies-msf-experience-in-minkaman-south-sudan
#4
Monica Rull, Sophie Masson, Nicolas Peyraud, Marco Simonelli, Alexandre Ventura, Claire Dorion, Francisco J Luquero, Florent Uzzeni, Iza Cigleneki
Introduction: The main causes of death during population movements can be prevented by addressing the population's basic needs. In 2013, the World Health Organization (WHO) issued a framework for decision making to help prioritize vaccinations in acute humanitarian emergencies. This article describes MSF's experience of applying this framework in addition to addressing key population needs in a displacement setting in Minkaman, South Sudan. Case description: Military clashes broke out in South Sudan in December 2013...
2018: Conflict and Health
https://www.readbyqxmd.com/read/29581192/characterization-of-individual-human-antibodies-binding-pertussis-toxin-stimulated-by-acellular-immunization
#5
Edith Acquaye-Seedah, Elizabeth E Reczek, Hugh H Russell, Andrea M DiVenere, Sara O Sandman, Joseph H Collins, Caitlin A Stein, Timothy A Whitehead, Jennifer A Maynard
Despite high vaccination rates, the incidence of whooping cough has been steadily increasing in developing countries for several decades. The current acellular pertussis (aP) vaccines all include the major protective antigen pertussis toxin (PTx) and are safer, but appear less protective than infection or older whole cell vaccines. To better understand the attributes of individual antibodies stimulated by aP, we isolated plasmablast clones recognizing PTx after booster immunization of two donors. Five unique antibody sequences recognizing native PTx were recovered and expressed as recombinant human IgG1 antibodies...
March 26, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29577759/-seroprevalence-of-bordetella-pertussis-antibodies-in-adults-in-hungary-results-of-an-epidemiological-cross-sectional-study
#6
Péter Torzsa, Devadiga Raghavendra, Monica Tafalla
INTRODUCTION: Pertussis (whooping cough) is an acute respiratory tract infection caused by Bordetella pertussis that is characterized by a chronic, severe cough. The optimum immunization schedule for pertussis is unclear, so these vary by countries. AIM: To estimate the seroprevalence of pertussis in adults in Hungary. METHOD: Serum anti-pertussis toxin immunoglobulin G (anti-PT IgG) antibody levels were analyzed using enzyme-linked immunosorbent assay in adults in general practitioners' practices during one year...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29559630/bordetella-pertussis-pertactin-knock-out-strains-reveal-immunomodulatory-properties-of-this-virulence-factor
#7
Elise Sofie Hovingh, Rob Mariman, Luis Solans, Daniëlle Hijdra, Hendrik-Jan Hamstra, Ilse Jongerius, Marjolein van Gent, Frits Mooi, Camille Locht, Elena Pinelli
Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some countries represent up to 95% of recent clinical isolates. Knowledge on the effect that Prn deficiency has on infection and immunity to B. pertussis is crucial for the development of new strategies to control this disease. Here, we characterized the effect of Prn production by B...
March 21, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29546932/-rectal-prolapse-as-an-unusual-presentation-of-celiac-disease-report-of-two-cases
#8
Germán Errázuriz
INTRODUCTION: Rectal prolapse (RP) is related to an increase of intra-abdominal pressure, pelvic floor disease or anal sphincter. The most common causes of RP are constipation, cystic fibrosis, whooping cough and dysenteric diarrhea. However, celiac disease is not considered among the pathologies re lated to RP. OBJECTIVE: To present a scarcely described association between RP and celiac disease. CLINICAL CASES: We presented 2 preschoolers in whom the reason for consultation was RP, whose study was focused on as prolonged diarrhea, due to the antecedent of pasty consistency of stools...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29531137/the-adjuvant-bordetella-colonization-factor-a-attenuates-alum-induced-th2-responses-and-enhances-bordetella-pertussis-clearance-from-mouse-lungs
#9
Jamie Jennings-Gee, Sally Quataert, Tridib Ganguly, Ralph D'Agostino, Rajendar Deora, Purnima Dubey
The reemergence of pertussis or whooping cough in several countries highlights the need for better vaccines. Acellular pertussis vaccines (aPV) contain alum as the adjuvant and elicit Th2 biased immune responses that are less effective in protecting against infection than the reactogenic whole cell pertussis vaccines (wPV), which elicit primarily a Th1/Th17 response. An important goal for the field is to devise aPVs that will induce immune responses similar to wPV. We show that Bordetella Colonization Factor A (BcfA), an outer membrane protein from B...
March 12, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29487240/coiled-coil-antagonism-regulates-activity-of-venus-flytrap-domain-containing-sensor-kinases-of-the-bvgs-family
#10
Elodie Lesne, Elian Dupré, Marc F Lensink, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson
Bordetella pertussis controls the expression of its virulence regulon through the two-component system BvgAS. BvgS is a prototype for a family of multidomain sensor kinases. In BvgS, helical linkers connect periplasmic Venus flytrap (VFT) perception domains to a cytoplasmic Per-Arnt-Sim (PAS) domain and the PAS domain to the dimerization/histidine phosphotransfer (DHp) domain of the kinase. The two linkers can adopt coiled-coil structures but cannot do so simultaneously. The first linker forms a coiled coil in the kinase mode and the second in the phosphatase mode, with the other linker in both cases showing an increase in dynamic behavior...
February 27, 2018: MBio
https://www.readbyqxmd.com/read/29464899/proteomic-adaptation-of-australian-epidemic-bordetella-pertussis
#11
Laurence Don Wai Luu, Sophie Octavia, Ling Zhong, Mark Raftery, Vitali Sintchenko, Ruiting Lan
Bordetella pertussis causes whooping cough. The predominant strains in Australia changed to single nucleotide polymorphism (SNP) cluster I (pertussis toxin promoter allele ptxP3/pertactin gene allele prn2) from cluster II (non-ptxP3/non-prn2). Cluster I were mostly responsible for the 2008-2012 Australian epidemic and were found to have higher fitness compared to cluster II using an in vivo mouse competition assay, regardless of host's immunisation status. This study aimed to identify proteomic differences that explain higher fitness in cluster I using iTRAQ, and high-resolution multiple reaction monitoring (MRM-hr)...
February 21, 2018: Proteomics
https://www.readbyqxmd.com/read/29455870/detection-and-incidence-of-bordetella-holmesii-in-respiratory-specimens-from-patients-with-pertussis-like-symptoms-in-new-south-wales-australia
#12
Winkie Fong, Verlaine Timms, Nadine Holmes, Vitali Sintchenko
Bordetella pertussis, the aetiological agent of whooping cough is routinely diagnosed by polymerase chain reaction (PCR) directed at IS481, an insertion sequence target also found in Bordetella holmesii. Recent reports have suggested that B. holmesii infections can be misdiagnosed as pertussis, which can have a significant impact on public health surveillance. This study investigated the presence of B. holmesii in B. pertussis positive clinical samples, in order to determine the incidence of B. holmesii. Clinical cases of pertussis diagnosed by IS481-specific PCR between October 2008 and March 2016 in New South Wales were included...
February 15, 2018: Pathology
https://www.readbyqxmd.com/read/29433898/construction-and-evaluation-of-bordetella-pertussis-live-attenuated-vaccine-strain-bpze1-producing-fim3
#13
Anne-Sophie Debrie, Loïc Coutte, Dominique Raze, Frits Mooi, Frances Alexander, Andrew Gorringe, Nathalie Mielcarek, Camille Locht
Pertussis or whooping cough is currently the most prevalent vaccine-preventable childhood disease despite >85% global vaccination coverage. In recent years incidence has greatly increased in several high-income countries that have switched from the first-generation, whole-cell vaccine to the newer acellular vaccines, calling for improved vaccination strategies with better vaccines. We have developed a live attenuated pertussis vaccine candidate, called BPZE1, which is currently in clinical development. Unlike other pertussis vaccines, BPZE1 has been shown to provide strong protection against infection by the causative agent of pertussis, Bordetella pertussis, in non-human primates...
February 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29429812/bordetella-pertussis-bp-disease-before-2003-2011-and-after-2013-2016-maternal-immunization-strategy-in-a-pediatric-hospital
#14
Angela Gentile, María Del Valle Juarez, María Florencia Lucion, Ana Clara Martínez, Viviana Romanin, Soledad Areso, Alicia Mistchenko
INTRODUCTION: Whooping cough continues to be a major cause of morbidity and mortality in infants younger than 1 year. In 2012, Argentina introduced Tdap in pregnancy to prevent infant mortality. The aim of this study is to describe the impact of maternal immunization on the hospitalization and mortality rates of confirmed Bordetella pertussis (Bp) cases by comparing pre- and post-Tdap vaccine recommendation periods. MATERIAL AND METHODS: All PCR-confirmed Bp cases from "R...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29399582/outbreak-investigation-of-pertussis-in-an-elementary-school-a-case-control-study-among-vaccinated-students
#15
Sukhyun Ryu, Joon Jai Kim, Meng-Yu Chen, Hyunju Jin, Hyun Kyung Lee, Byung Chul Chun
Purpose: A pertussis patient from an elementary school, in Gyeonggi Province, Korea, was notified to public health authority on July 25, 2017. Epidemiologic investigation was conducted to identify the magnitude, possible source of infection and risk factors for this outbreak on August 17, 2017. Materials and Methods: A case was defined as the school student experiencing cough for more than two weeks with or without paroxysmal, whoop, or post-tussive vomiting. Control was defined as the student polymerase chain reaction-negative at the school...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29387937/a-systematic-approach-for-finding-the-objective-function-and-active-constraints-for-dynamic-flux-balance-analysis
#16
Ali Nikdel, Richard D Braatz, Hector M Budman
Dynamic flux balance analysis (DFBA) has become an instrumental modeling tool for describing the dynamic behavior of bioprocesses. DFBA involves the maximization of a biologically meaningful objective subject to kinetic constraints on the rate of consumption/production of metabolites. In this paper, we propose a systematic data-based approach for finding both the biological objective function and a minimum set of active constraints necessary for matching the model predictions to the experimental data. The proposed algorithm accounts for the errors in the experiments and eliminates the need for ad hoc choices of objective function and constraints as done in previous studies...
February 1, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29346585/maternal-vaccination-with-a-monocomponent-pertussis-toxoid-vaccine-is-sufficient-to-protect-infants-in-a-baboon-model-of-whooping-cough
#17
Parul Kapil, James F Papin, Roman F Wolf, Lindsey I Zimmerman, Leslie D Wagner, Tod J Merkel
Background: Bordetella pertussis is a human pathogen responsible for serious respiratory illness. The disease is most severe in infants too young to be vaccinated with most hospitalizations and deaths occurring within this age group. The Advisory Committee on Immunization Practices recommended immunization of pregnant women to protect infants from birth until their first vaccination at 6-8 weeks of age. We previously demonstrated that maternal vaccination with licensed acellular pertussis vaccines protected newborn baboons from disease...
March 28, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29337218/calcium-dependent-disorder-to-order-transitions-are-central-to-the-secretion-and-folding-of-the-cyaa-toxin-of-bordetella-pertussis-the-causative-agent-of-whooping-cough
#18
Darragh P O'Brien, Ana Cristina Sotomayor Perez, Johanna Karst, Sara E Cannella, Véronique Yvette Ntsogo Enguéné, Audrey Hessel, Dorothée Raoux-Barbot, Alexis Voegele, Orso Subrini, Marilyne Davi, J Inaki Guijarro, Bertrand Raynal, Bruno Baron, Patrick England, Belen Hernandez, Mahmoud Ghomi, Véronique Hourdel, Christian Malosse, Julia Chamot-Rooke, Patrice Vachette, Dominique Durand, Sébastien Brier, Daniel Ladant, Alexandre Chenal
The adenylate cyclase toxin (CyaA) plays an essential role in the early stages of respiratory tract colonization by Bordetella pertussis, the causative agent of whooping cough. Once secreted, CyaA invades eukaryotic cells, leading to cell death. The cell intoxication process involves a unique mechanism of translocation of the CyaA catalytic domain directly across the plasma membrane of the target cell. Herein, we review our recent results describing how calcium is involved in several steps of this intoxication process...
January 12, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29306640/species-interactions-may-help-explain-the-erratic-periodicity-of-whooping-cough-dynamics
#19
Samit Bhattacharyya, Matthew J Ferrari, Ottar N Bjørnstad
Incidence of whooping cough exhibits variable dynamics across time and space. The periodicity of this disease varies from annual to five years in different geographic regions in both developing and developed countries. Many hypotheses have been put forward to explain this variability such as nonlinearity and seasonality, stochasticity, variable recruitment of susceptible individuals via birth, immunization, and immune boosting. We propose an alternative hypothesis to describe the variability in periodicity - the intricate dynamical variability of whooping cough may arise from interactions between its dominant etiological agents of Bordetella pertussis and Bordetella parapertussis...
December 14, 2017: Epidemics
https://www.readbyqxmd.com/read/29238457/molecular-detection-of-bordetella-holmesii-in-two-infants-with-pertussis-like-syndrome-the-first-report-from-iran
#20
Masoumeh Nakhost Lotfi, Vajiheh Sadat Nikbin, Omid Nasiri, Farzad Badmasti, Fereshteh Shahcheraghi
Background and Objectives: Bordetella holmesii is associated with a pertussis-like respiratory syndrome in healthy individuals and also a rare cause of septicaemia, endocarditis, pneumonia, and septic arthritis, mostly in immunocompromised patients. Culture technique and real-time PCR are 2 methods used to detect Bordetella spp. Materials and Methods: In this study, 435 nasopharyngeal specimens of patients with suspected whooping cough were checked for the presence of B...
August 2017: Iranian Journal of Microbiology
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