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https://www.readbyqxmd.com/read/29223471/-clinical-epidemiological-study-of-bordetella-pertussis-infection-in-the-gran-canaria-island-in-the-period-2008-2016
#1
Laura Iglesias, Antonio Casabella Pernas, Melisa Hernández Febles, Elena Colino Gil, Alicia Eisman Maraver, María José Pena López
OBJECTIVE: Describe the epidemiological and clinical pattern of Bordetella pertussis infection (whooping cough) among hospitalised infants less than one year-old in a paediatric hospital in Gran Canaria. PATIENTS AND METHODS: A retrospective review of the patient hospital records was performed, and recording only those with a microbiological diagnosis of pertussis infection detected using polymerase chain reaction, from January 2008 to December 2016. RESULTS: A total of 110 patients were identified, of which 105 (95...
December 6, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29205108/contributions-of-the-hydrophobic-helix-2-of-the-bordetella-pertussis-cyaa-hemolysin-to-membrane-permeabilization
#2
Panchika Prangkio, Sirikran Juntapremjit, Melanie Koehler, Peter Hinterdorfer, Chanan Angsuthanasombat
Adenylate cyclase (CyaA) is one of the major virulence factors of Bordetella pertussis that plays a key role in whooping cough pathogenesis. A putative transmembrane helical hairpin (α2-loop-α3), encompassing residues 529-594 of CyaA hemolysin (CyaA-Hly) domain, was previously proposed to be crucially involved in hemolytic activity against target erythrocytes. Here, to gain more insight into membrane permeabilization of this toxin, synthetic peptides corresponding to this critical helical component, i.e. α2 (W528-G550), α3 (G568-R594) and α2-loop-α3 (W528-R594), were examined on various membrane models in comparison with the purified 130-kDa CyaA-Hly...
December 1, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29203545/bordetella-pertussis-adenylate-cyclase-toxin-disrupts-functional-integrity-of-bronchial-epithelial-layers
#3
Shakir Hasan, Nikhil Nitin Kulkarni, Arni Asbjarnarson, Irena Linhartova, Radim Osicka, Peter Sebo, Gudmundur H Gudmundsson
Airway epithelium restricts penetration of inhaled pathogens into the underlying tissue and plays a crucial role in innate immune defense against respiratory infections. The whooping cough agent, Bordetella pertussis, adheres to ciliated cells of human airway epithelium and subverts its defense functions through the action of secreted toxins and other virulence factors. We have examined the impact of B. pertussis infection and of adenylate cyclase toxin (CyaA) action on the functional integrity of air-liquid interface (ALI)-cultured human bronchial epithelial cells...
December 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29203497/outer-membrane-vesicles-omv-based-and-proteomics-driven-antigen-selection-identifies-novel-factors-contributing-to-bordetella-pertussis-adhesion-to-epithelial-cells
#4
Gianmarco Gasperini, Massimiliano Biagini, Vanessa Arato, Claudia Gianfaldoni, Alessandro Vadi, Nathalie Norais, Giuliano Bensi, Isabel Delany, Mariagrazia Pizza, Beatrice Aricò, Rosanna Leuzzi
Despite high vaccination coverage world-wide, whooping cough, a highly contagious disease caused by Bordetella pertussis, is recently increasing in occurrence suggesting that novel vaccine formulations targeted at the prevention of colonization and transmission should be investigated. In order to identify new candidates for inclusion in the acellular formulation, we used spontaneously released outer membrane vesicles (OMV) as a potential source of key adhesins. The enrichment of Bvg+ OMV with adhesins and the ability of anti-OMV serum to inhibit the adhesion of B...
December 4, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29182938/does-disease-cause-vaccination-disease-outbreaks-and-vaccination-response
#5
Emily Oster
Parental fear of vaccines has limited vaccination rates in the United States. I test whether disease outbreaks increase vaccination using a new dataset of county-level disease and vaccination data. I find that pertussis (whooping cough) outbreaks in a county decrease the share of unvaccinated children entering kindergarten. These responses do not reflect changes in the future disease risk. I argue that these facts are best fit by a model in which individuals are both myopic and irrational. This suggests that better promotion of information about outbreaks could enhance the response...
November 2, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/29176673/phosphoproteomics-of-camp-signaling-of-bordetella-adenylate-cyclase-toxin-in-mouse-dendritic-cells
#6
Jakub Novák, Ivo Fabrik, Irena Linhartová, Marek Link, Ondřej Černý, Jiří Stulík, Peter Šebo
The adenylate cyclase toxin (CyaA) of the whooping cough agent Bordetella pertussis subverts immune functions of host myeloid cells expressing the αMβ2 integrin (CD11b/CD18, CR3 or Mac-1). CyaA delivers into cytosol of cells an extremely catalytically active adenylyl cyclase enzyme, which disrupts the innate and adaptive immune functions of phagocytes through unregulated production of the key signaling molecule cAMP. We have used phosphoproteomics to analyze cAMP signaling of CyaA in murine bone marrow-derived dendritic cells...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29166874/efficacy-and-safety-of-pertussis-vaccination-for-pregnant-women-a-systematic-review-of-randomised-controlled-trials-and-observational-studies
#7
Marie Furuta, Jacqueline Sin, Edmond S W Ng, Kay Wang
BACKGROUND: Worldwide, pertussis remains a major health problem among children. During the recent outbreaks of pertussis, maternal antenatal immunisation was introduced in several industrial countries. This systematic review aimed to synthesize evidence for the efficacy and safety of the pertussis vaccination that was given to pregnant women to protect infants from pertussis infection. METHODS: We searched literature in the Cochrane Central Register of Controlled Trials, Medline, Embase, and OpenGrey between inception of the various databases and 16 May 2016...
November 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29164393/bordetella-pertussis-virulence-factors-in-the-continuing-evolution-of-whooping-cough-vaccines-for-improved-performance
#8
REVIEW
Dorji Dorji, Frits Mooi, Osvaldo Yantorno, Rajendar Deora, Ross M Graham, Trilochan K Mukkur
Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced the mortality due to pertussis. Despite induction of both antibody and cell-mediated immune (CMI) responses by aP and wP vaccines, there has been resurgence of pertussis in many countries in recent years. Possible reasons hypothesised for resurgence have ranged from incompliance with the recommended vaccination programmes with the currently used aP vaccine to infection with a resurged clinical isolates characterised by mutations in the virulence factors, resulting in antigenic divergence with vaccine strain, and increased production of pertussis toxin, resulting in dampening of immune responses...
November 21, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29158617/pertussis-outbreak-in-polish-shooters-with-adverse-event-analysis
#9
Monika Skrzypiec-Spring, Jarosław Krzywański, Monika Karlikowska-Skwarnik, Andrzej Pokrywka, Hubert Krysztofiak, Aneta Nitsch-Osuch, Ernest Kuchar
In addition to different injuries, infections are the most common reason for giving up training altogether or reducing its volume and intensity, as well as a lack of opportunities to participate in sports competitions. Nowadays, a slow but constant re-emergence of pertussis, especially among teenagers and young adults, including athletes, can be observed. This paper describes an outbreak of pertussis among professional Polish shooters, focusing on the transmission of Bordetella pertussis infection between members of the national team, its influence on performance capacity and adverse event analysis...
September 2017: Biology of Sport
https://www.readbyqxmd.com/read/29135925/membrane-active-properties-of-an-amphitropic-peptide-from-the-cyaa-toxin-translocation-region
#10
Alexis Voegele, Orso Subrini, Nicolas Sapay, Daniel Ladant, Alexandre Chenal
The adenylate cyclase toxin CyaA is involved in the early stages of infection by Bordetella pertussis, the causative agent of whooping cough. CyaA intoxicates target cells by a direct translocation of its catalytic domain (AC) across the plasma membrane and produces supraphysiological levels of cAMP, leading to cell death. The molecular process of AC translocation remains largely unknown, however. We have previously shown that deletion of residues 375-485 of CyaA selectively abrogates AC translocation into eukaryotic cells...
November 14, 2017: Toxins
https://www.readbyqxmd.com/read/29094317/pertussis-and-parapertussis-in-children-and-adults-with-a-persistent-cough-an-observational-study
#11
Piia Jõgi, Marje Oona, Tanel Kaart, Karolin Toompere, Tereza Maskina, Iris Koort, Anneli Rätsep, Irja Lutsar
PURPOSE: We aimed to determine the prevalence, symptoms and course of pertussis and parapertussis among patients at any age with a cough of unknown aetiology that had lasted for ≥ 7 days and to assess the diagnostic value of the symptoms included in the World Health Organisations' (WHO) clinical case definition of pertussis. METHODS: Patients were enrolled between the 23 April 2012 and 31 December 2014 at 25 general practitioner (GP) centres and three paediatric hospitals...
November 1, 2017: Infection
https://www.readbyqxmd.com/read/29076101/bordetella-pertussis-infection-in-hospitalized-infants-with-acute-bronchiolitis
#12
Şule Gökçe, Zafer Kurugöl, S Şöhret Aydemir, Candan Çiçek, Aslı Aslan, Güldane Koturoğlu
OBJECTIVE: To assess the frequency of B. pertussis infection among young infants hospitalized with acute bronchiolitis and to determine whether B. pertussis infection affects the clinical course of acute bronchiolitis. METHODS: A total of 172 infants <6 months of age hospitalized with acute bronchiolitis were tested for B. pertussis and respiratory viruses with real-time PCR. Cases were divided into 2 groups according to B. pertussis positive or negative. Clinical parameters, clinical severity scores and laboratory characteristics of the pertussis-positive and pertussis-negative cases were compared...
October 27, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29068748/recommendation-system-for-immunization-coverage-and-monitoring
#13
Uzair Aslam Bhatti, Mengxing Huang, Hao Wang, Yu Zhang, Anum Mehmood, Wu Di
Immunization averts an expected 2 to 3 million deaths every year from diphtheria, tetanus, pertussis (whooping cough), and measles; however, an additional 1.5 million deaths could be avoided if vaccination coverage was improved worldwide. (1)(1) Data source for immunization records of 1.5 M: http://www.who.int/mediacentre/factsheets/fs378/en/ New vaccination technologies provide earlier diagnoses, personalized treatments and a wide range of other benefits for both patients and health care professionals. Childhood diseases that were commonplace less than a generation ago have become rare because of vaccines...
October 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29052540/emergence-of-bordetella-holmesii-as-a-causative-agent-of-whooping-cough-barcelona-spain
#14
Alba Mir-Cros, Gema Codina, M Teresa Martín-Gómez, Anna Fàbrega, Xavier Martínez, Mireia Jané, Diego Van Esso, Thais Cornejo, Carlos Rodrigo, Magda Campins, Tomàs Pumarola, Juan José González-López
We describe the detection of Bordetella holmesii as a cause of whooping cough in Spain. Prevalence was 3.9% in 2015, doubling to 8.8% in 2016. This emergence raises concern regarding the contribution of B. holmesii to the reemergence of whooping cough and the effectiveness of the pertussis vaccine.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29037454/incidence-of-pertussis-in-subjects-aged-50years-and-older-in-france-in-2013-2014
#15
N Guiso, J-L Gallais, G Gavazzi, D Pinquier, J Gaillat
OBJECTIVE: To assess the incidence of pertussis (whooping cough) in subjects aged 50years and older in France. METHODS: Participating family physicians (FPs) using the patient record management software AxiSanté(®) included patients aged 50years and older, who had signed an informed consent form, presenting with persistent cough for 7 to 21days. Bordetella genetic material was detected by polymerase chain reaction (PCR) on nasopharyngeal samples collected at the FP's discretion...
October 13, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29031695/-hesitant-compliers-qualitative-analysis-of-concerned-fully-vaccinating-parents
#16
Stephanie L Enkel, Katie Attwell, Thomas L Snelling, Hayley E Christian
OBJECTIVE: Some parents are hesitant about vaccines and yet still vaccinate their children. Vaccine behaviours are not fixed and parents who are concerned but nonetheless adherent to standard schedules could switch to an unconventional schedule, delaying or cherry-picking vaccines. There is a need to better understand vaccine hesitancy in specific contexts, acknowledging cultural and geographical variation, to ensure interventions targeting hesitancy are well directed and received. METHODS: To identify the behaviours, knowledge and attitudes of 'hesitant compliers' in Perth, Western Australia, nine one-on-one in-depth interviews were conducted with vaccinating parents of children (<5 years) who were identified as being hesitant...
October 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29026471/pertussis-and-pertussis-like-illness-pediatric-experience-in-oman
#17
Amal Al Maani, Abdullah Al Qayoudhi, Hanan Fawzi Nazir, Heba Omar, Amina Al Jardani, Zakariya Al Muharrmi, Yasser Wali
OBJECTIVES: A resurgence of pertussis or whooping cough has been observed worldwide despite broad vaccination coverage. Pertussis like illness (PLI) refers to a clinical syndrome compatible with pertussis infection but lacking laboratory confirmation or an epidemiological link to a confirmed case. Our study aimed to estimate the contribution of Bordetella pertussis infection and identifying predictors of its diagnosis in a cohort of children with PLI. METHODS: Demographic and clinical information were retrospectively collected from the medical records of children < 13 years old and hospitalized for PLI in two pediatric units in Oman from 1 January 2012 to 31 December 2013...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29018122/the-bvgas-regulon-of-bordetella-pertussis
#18
Kyung Moon, Richard P Bonocora, David D Kim, Qing Chen, Joseph T Wade, Scott Stibitz, Deborah M Hinton
Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. When BvgS is active, BvgA is phosphorylated (BvgA~P), and virulence-activated genes (vags) are expressed [Bvg(+) mode]. When BvgS is inactive and BvgA is not phosphorylated, virulence-repressed genes (vrgs) are induced [Bvg(-) mode]. Here, we have used transcriptome sequencing (RNA-seq) and reverse transcription-quantitative PCR (RT-qPCR) to define the BvgAS-dependent regulon of B...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/28987075/whooping-cough-alleviated-by-homeopathic-medicines-a-case-report
#19
Youngran Chung
Context • Pertussis cough (whooping cough) is distressing due to the intensity and chronicity of its cough. No specific drugs are available that can alleviate the cough's intensity or significantly shorten its duration. Homeopathic medicines are used for a wide variety of medical conditions, including cough. Objective • The study investigated the benefits of homeopathic medicines for whooping cough, to alleviate the cough's intensity and to shorten its duration. Design • The current study was a case series of patients with whooping cough...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28974408/whooping-cough-surveillance-in-france-in-pediatric-private-practice-in-2006-2015
#20
Nicole Guiso, Corinne Levy, Olivier Romain, Sophie Guillot, Andreas Werner, Marie Charlotte Rondeau, Stéphane Béchet, Robert Cohen
BACKGROUND: Increasing incidence of whooping cough (pertussis) has been reported in many countries, attributed to a switch from whole-cell pertussis-containing vaccine (wPV) to acellular PV (aPV) and circulation of the pertactin non-producing Bordetella pertussis. The present study aimed to estimate the duration of immunity conferred by PVs in children in France with data from an ongoing pediatric ambulatory surveillance of pertussis. METHODS: A total of 64 pediatricians throughout France enrolled children with suspected pertussis...
October 27, 2017: Vaccine
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