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https://www.readbyqxmd.com/read/29037454/incidence-of-pertussis-in-subjects-aged-50years-and-older-in-france-in-2013-2014
#1
N Guiso, J-L Gallais, G Gavazzi, D Pinquier, J Gaillat
OBJECTIVE: To assess the incidence of pertussis (whooping cough) in subjects aged 50years and older in France. METHODS: Participating family physicians (FPs) using the patient record management software AxiSanté(®) included patients aged 50years and older, who had signed an informed consent form, presenting with persistent cough for 7 to 21days. Bordetella genetic material was detected by polymerase chain reaction (PCR) on nasopharyngeal samples collected at the FP's discretion...
October 13, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29031695/-hesitant-compliers-qualitative-analysis-of-concerned-fully-vaccinating-parents
#2
Stephanie L Enkel, Katie Attwell, Thomas L Snelling, Hayley E Christian
OBJECTIVE: Some parents are hesitant about vaccines and yet still vaccinate their children. Vaccine behaviours are not fixed and parents who are concerned but nonetheless adherent to standard schedules could switch to an unconventional schedule, delaying or cherry-picking vaccines. There is a need to better understand vaccine hesitancy in specific contexts, acknowledging cultural and geographical variation, to ensure interventions targeting hesitancy are well directed and received. METHODS: To identify the behaviours, knowledge and attitudes of 'hesitant compliers' in Perth, Western Australia, nine one-on-one in-depth interviews were conducted with vaccinating parents of children (<5 years) who were identified as being hesitant...
October 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29026471/pertussis-and-pertussis-like-illness-pediatric-experience-in-oman
#3
Amal Al Maani, Abdullah Al Qayoudhi, Hanan Fawzi Nazir, Heba Omar, Amina Al Jardani, Zakariya Al Muharrmi, Yasser Wali
OBJECTIVES: A resurgence of pertussis or whooping cough has been observed worldwide despite broad vaccination coverage. Pertussis like illness (PLI) refers to a clinical syndrome compatible with pertussis infection but lacking laboratory confirmation or an epidemiological link to a confirmed case. Our study aimed to estimate the contribution of Bordetella pertussis infection and identifying predictors of its diagnosis in a cohort of children with PLI. METHODS: Demographic and clinical information were retrospectively collected from the medical records of children < 13 years old and hospitalized for PLI in two pediatric units in Oman from 1 January 2012 to 31 December 2013...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29018122/the-bvgas-regulon-of-bordetella-pertussis
#4
Kyung Moon, Richard P Bonocora, David D Kim, Qing Chen, Joseph T Wade, Scott Stibitz, Deborah M Hinton
Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. When BvgS is active, BvgA is phosphorylated (BvgA~P), and virulence-activated genes (vags) are expressed [Bvg(+) mode]. When BvgS is inactive and BvgA is not phosphorylated, virulence-repressed genes (vrgs) are induced [Bvg(-) mode]. Here, we have used transcriptome sequencing (RNA-seq) and reverse transcription-quantitative PCR (RT-qPCR) to define the BvgAS-dependent regulon of B...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/28987075/whooping-cough-alleviated-by-homeopathic-medicines-a-case-report
#5
Youngran Chung
Context • Pertussis cough (whooping cough) is distressing due to the intensity and chronicity of its cough. No specific drugs are available that can alleviate the cough's intensity or significantly shorten its duration. Homeopathic medicines are used for a wide variety of medical conditions, including cough. Objective • The study investigated the benefits of homeopathic medicines for whooping cough, to alleviate the cough's intensity and to shorten its duration. Design • The current study was a case series of patients with whooping cough...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28974408/whooping-cough-surveillance-in-france-in-pediatric-private-practice-in-2006-2015
#6
Nicole Guiso, Corinne Levy, Olivier Romain, Sophie Guillot, Andreas Werner, Marie Charlotte Rondeau, Stéphane Béchet, Robert Cohen
BACKGROUND: Increasing incidence of whooping cough (pertussis) has been reported in many countries, attributed to a switch from whole-cell pertussis-containing vaccine (wPV) to acellular PV (aPV) and circulation of the pertactin non-producing Bordetella pertussis. The present study aimed to estimate the duration of immunity conferred by PVs in children in France with data from an ongoing pediatric ambulatory surveillance of pertussis. METHODS: A total of 64 pediatricians throughout France enrolled children with suspected pertussis...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28973366/an-extracellular-polysaccharide-locus-required-for-transmission-of-bordetella-bronchiseptica
#7
Kalyan K Dewan, Dawn L Taylor-Mulneix, Lindsay J Hilburger, Israel Rivera, Andrew Preston, Eric T Harvill
Background: The lack of animal models to experimentally study how infectious agents transmit between hosts limits our understanding of what makes some pathogens so contagious. Methods: We recently developed a Bordetella bronchiseptica mouse model to study transmission and have used it to assess, for the first time, which of several well-studied "virulence factors" common to classical Bordetella species contribute to transmission. Results: Among 13 mutants screened, a mutant lacking an extracellular polysaccharide (EPS) locus consistently failed to transmit...
July 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28954396/characterization-of-post-translational-modifications-and-cytotoxic-properties-of-the-adenylate-cyclase-hemolysin-produced-by-various-bordetella-pertussis-and-bordetella-parapertussis-isolates
#8
Valérie Bouchez, Thibaut Douché, Mélody Dazas, Sophie Delaplane, Mariette Matondo, Julia Chamot-Rooke, Nicole Guiso
Bordetella pertussis and Bordetella parapertussis are the causal agents of whooping cough in humans. They produce diverse virulence factors, including adenylate cyclase-hemolysin (AC-Hly), a secreted toxin of the repeat in toxins (RTX) family with cyclase, pore-forming, and hemolytic activities. Post-translational modifications (PTMs) are essential for the biological activities of the toxin produced by B. pertussis. In this study, we compared AC-Hly toxins from various clinical isolates of B. pertussis and B...
September 26, 2017: Toxins
https://www.readbyqxmd.com/read/28948804/-serological-diagnosis-of-whooping-cough-using-immunoblot-methods
#9
I Lochman, L Pokorná, H Mertová
THE AIM OF STUDY: The aim of this study was to challenge the conclusion presented in the current recommendations of the EU Perstrain Group (European group of reference laboratories) [17] that immunoblotting methods are not appropriate serological methods for the diagnosis of pertussis because their results cannot be quantified. To consider benefits of these methods for the diagnosis of Bordetella infections was another aim of this work. MATERIAL AND METHODS: The residual sera from routine testing intended for disposal and results of routine tests for Bordetella infections performed in Spadia Lab in 2015 and 2016 were used in this study...
2017: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/28939637/retinal-haemorrhage-in-infants-with-pertussis
#10
Naz Raoof, Susana Pereira, Shuan Dai, Jocelyn Neutze, Cameron Charles Grant, Patrick Kelly
AIMS: It has been hypothesised that paroxysmal coughing in infantile pertussis (whooping cough) could produce retinal haemorrhages identical to those seen in abusive head trauma. We aimed to test this hypothesis. METHODS: This is a prospective study of infants hospitalised with pertussis in Auckland, New Zealand, from 2009 to 2014. The clinical severity of pertussis was categorised. All infants recruited had retinal examination through dilated pupils by the paediatric ophthalmology service using an indirect ophthalmoscope...
September 22, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28934133/understanding-the-mechanism-of-translocation-of-adenylate-cyclase-toxin-across-biological-membranes
#11
REVIEW
Helena Ostolaza, César Martín, David González-Bullón, Kepa B Uribe, Asier Etxaniz
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease. ACT targets phagocytes via binding to the CD11b/CD18 integrin and delivers its N-terminal adenylate cyclase (AC) domain directly to the cell cytosol, where it catalyzes unregulated conversion of cytosolic ATP into cAMP upon activation by binding to cellular calmodulin...
September 21, 2017: Toxins
https://www.readbyqxmd.com/read/28928960/the-relationship-between-mucosal-immunity-nasopharyngeal-carriage-asymptomatic-transmission-and-the-resurgence-of-bordetella-pertussis
#12
REVIEW
Christopher Gill, Pejman Rohani, Donald M Thea
The incidence of whooping cough in the US has been rising slowly since the 1970s, but the pace of this has accelerated sharply since acellular pertussis vaccines replaced the earlier whole cell vaccines in the late 1990s. A similar trend occurred in many other countries, including the UK, Canada, Australia, Ireland, and Spain, following the switch to acellular vaccines. The key question is why. Two leading theories (short duration of protective immunologic persistence and evolutionary shifts in the pathogen to evade the vaccine) explain some but not all of these shifts, suggesting that other factors may also be important...
2017: F1000Research
https://www.readbyqxmd.com/read/28893915/hyperbiofilm-formation-by-bordetella-pertussis-strains-correlates-with-enhanced-virulence-traits
#13
Natalia Cattelan, Jamie Jennings-Gee, Purnima Dubey, Osvaldo M Yantorno, Rajendar Deora
Pertussis or whooping cough caused by the obligate human pathogen Bordetella pertussis is undergoing a world-wide resurgence. Majority of studies with this pathogen are conducted with laboratory-adapted strains which may not be representative of the species as a whole. Biofilm formation by B. pertussis plays an important role in its pathogenesis. We conducted a side-by side comparison of the biofilm forming ability of the prototype laboratory strains with currently circulating isolates from two countries with different vaccination programs...
September 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28892012/bordetella-adenylate-cyclase-hemolysin-toxins
#14
REVIEW
Nicole Guiso
Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus Bordetella: Bordetella pertussis, B. parapertussis and B. bronchiseptica. This toxin has several properties such as: (i) adenylate cyclase activity, enhanced after interaction with the eukaryotic protein, calmodulin; (ii) a pore-forming activity; (iii) an invasive activity. It plays an important role in the pathogenesis of these Bordetella species responsible for whooping cough in humans or persistent respiratory infections in mammals, by modulating host immune responses...
September 11, 2017: Toxins
https://www.readbyqxmd.com/read/28857261/a-recombinant-iron-transport-protein-from-bordetella-pertussis-confers-protection-against-bordetella-parapertussis
#15
Jimena Alvarez Hayes, Juan Marcos Oviedo, Hugo Valdez, Juan Martín Laborde, Fabricio Maschi, Miguel Ayala, Rohan Shah, Marcelo Fernandez Lahore, Maria Eugenia Rodriguez
Whooping cough, which is caused by Bordetella pertussis and B. parapertussis, is a reemerging disease. New protective antigens are needed to improve the efficacy of current vaccines against both species. Using proteomic tools, it was here found that B. parapertussis expresses a homolog of AfuA, a previously reported new vaccine candidate against B. pertussis. It was found that this homolog, named AfuABpp , is expressed during B. parapertussis infection, exposed on the surface of the bacteria and recognized by specific antibodies induced by the recombinant AfuA cloned from B...
October 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28842544/probing-the-genome-scale-metabolic-landscape-of-bordetella-pertussis-the-causative-agent-of-whooping-cough
#16
Filipe Branco Dos Santos, Brett G Olivier, Joost Boele, Vincent Smessaert, Philippe De Rop, Petra Krumpochova, Gunnar W Klau, Martin Giera, Philippe Dehottay, Bas Teusink, Philippe Goffin
Whooping cough is a highly-contagious respiratory disease caused by Bordetella pertussis. Despite vaccination, its incidence has been rising alarmingly, and yet, the physiology of B. pertussis remains poorly understood. We combined genome-scale metabolic reconstruction, a novel optimization algorithm and experimental data to probe the full metabolic potential of this pathogen, using strain Tohama I as a reference. Experimental validation showed that B. pertussis secretes a significant proportion of nitrogen as arginine and purine nucleosides, which may contribute to modulation of the host response...
August 25, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28816807/a-whooping-cough-education-module-for-wic-clients-in-utah
#17
Karlen E Luthy, Alicia Anderson, Janelle Macintosh, Renea L Beckstrand, Lacey M Eden, Ryan Amy, Christopher I Macintosh
BACKGROUND: Clients in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) are required to complete education modules quarterly to maintain eligibility. The purposes of this project were to: (1) create a whooping cough vaccination education module for WIC clients; (2) evaluate baseline perceptions of WIC clients on the whooping cough vaccine and disease; and (3) evaluate whooping cough knowledge following completion of the module. PROBLEM: A decline in vaccination rates among infants and children using WIC services was reported by a local WIC program director who requested whooping cough vaccination education materials...
September 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28760979/phospholipase-a-activity-of-adenylate-cyclase-toxin-mediates-translocation-of-its-adenylate-cyclase-domain
#18
David González-Bullón, Kepa B Uribe, César Martín, Helena Ostolaza
Adenylate cyclase toxin (ACT or CyaA) plays a crucial role in respiratory tract colonization and virulence of the whooping cough causative bacterium Bordetella pertussis Secreted as soluble protein, it targets myeloid cells expressing the CD11b/CD18 integrin and on delivery of its N-terminal adenylate cyclase catalytic domain (AC domain) into the cytosol, generates uncontrolled toxic levels of cAMP that ablates bactericidal capacities of phagocytes. Our study deciphers the fundamentals of the heretofore poorly understood molecular mechanism by which the ACT enzyme domain directly crosses the host cell membrane...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28752940/protective-effects-of-in-vivo-expressed-autotransporters-against-bordetella-pertussis-infection
#19
Koichiro Suzuki, Naoaki Shinzawa, Keisuke Ishigaki, Keiji Nakamura, Hiroyuki Abe, Aya Fukui-Miyazaki, Kazuyoshi Ikuta, Yasuhiko Horiguchi
Bordetella pertussis causes whooping cough, a severe and prolonged respiratory disease that results in high morbidity and mortality rates, particularly in developing countries. The number of whooping cough cases is increasing in many countries despite high vaccine coverage. Causes for the re-emergence of the disease include the limited duration of protection conferred by the acellular pertussis vaccines (aP) and pathogenic adaptations that involve antigenic divergence from vaccine strains. Therefore, current vaccines need to be improved...
July 28, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28742139/acquisition-of-c1-inhibitor-by-bordetella-pertussis-virulence-associated-gene-8-results-in-c2-and-c4-consumption-away-from-the-bacterial-surface
#20
Elise S Hovingh, Bryan van den Broek, Betsy Kuipers, Elena Pinelli, Suzan H M Rooijakkers, Ilse Jongerius
Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is re-emerging worldwide despite high vaccination coverage. The causative agent of this disease is the Gram-negative Bordetella pertussis. Knowledge on complement evasion strategies of this pathogen is limited. However, this is of great importance for future vaccine development as it has become apparent that a novel pertussis vaccine is needed. Here, we unravel the effect of Virulence associated gene 8 (Vag8) of B. pertussis on the human complement system at the molecular level...
July 2017: PLoS Pathogens
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