keyword
MENU ▼
Read by QxMD icon Read
search

Whooping cough

keyword
https://www.readbyqxmd.com/read/28186111/stability-structural-and-functional-properties-of-a-monomeric-calcium-loaded-adenylate-cyclase-toxin-cyaa-from-bordetella-pertussis
#1
Sara E Cannella, Véronique Yvette Ntsogo Enguéné, Marilyne Davi, Christian Malosse, Ana Cristina Sotomayor Pérez, Julia Chamot-Rooke, Patrice Vachette, Dominique Durand, Daniel Ladant, Alexandre Chenal
Bordetella pertussis, the causative agent of whooping cough, secretes an adenylate cyclase toxin, CyaA, which invades eukaryotic cells and alters their physiology by cAMP overproduction. Calcium is an essential cofactor of CyaA, as it is the case for most members of the Repeat-in-ToXins (RTX) family. We show that the calcium-bound, monomeric form of CyaA, hCyaAm, conserves its permeabilization and haemolytic activities, even in a fully calcium-free environment. In contrast, hCyaAm requires sub-millimolar calcium in solution for cell invasion, indicating that free calcium in solution is involved in the CyaA toxin translocation process...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28174558/environmental-origin-of-the-genus-bordetella
#2
Illiassou Hamidou Soumana, Bodo Linz, Eric T Harvill
Members of the genus Bordetella include human and animal pathogens that cause a variety of respiratory infections, including whooping cough in humans. Despite the long known ability to switch between a within-animal and an extra-host lifestyle under laboratory growth conditions, no extra-host niches of pathogenic Bordetella species have been defined. To better understand the distribution of Bordetella species in the environment, we probed the NCBI nucleotide database with the 16S ribosomal RNA (16S rRNA) gene sequences from pathogenic Bordetella species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28167525/the-history-of-bordetella-pertussis-genome-evolution-includes-structural-rearrangement
#3
Michael R Weigand, Yanhui Peng, Vladimir Loparev, Dhwani Batra, Katherine E Bowden, Mark Burroughs, Pamela K Cassiday, Jamie K Davis, Taccara Johnson, Phalasy Juieng, Kristen Knipe, Marsenia H Mathis, Andrea M Pruitt, Lori Rowe, Mili Sheth, M Lucia Tondella, Margaret M Williams
: Despite high pertussis vaccine coverage, reported cases of whooping cough (pertussis) have increased over the last decade in the United States and other developed countries. Although Bordetella pertussis is well known for its limited gene sequence variation, recent advances in long-read sequencing technology have begun to reveal genome structural heterogeneity among otherwise indistinguishable isolates, even within geographically or temporally defined epidemics. We have compared rearrangements among complete genome assemblies from 257 B...
February 6, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28102319/temporal-topic-modeling-to-assess-associations-between-news-trends-and-infectious-disease-outbreaks
#4
Saurav Ghosh, Prithwish Chakraborty, Elaine O Nsoesie, Emily Cohn, Sumiko R Mekaru, John S Brownstein, Naren Ramakrishnan
In retrospective assessments, internet news reports have been shown to capture early reports of unknown infectious disease transmission prior to official laboratory confirmation. In general, media interest and reporting peaks and wanes during the course of an outbreak. In this study, we quantify the extent to which media interest during infectious disease outbreaks is indicative of trends of reported incidence. We introduce an approach that uses supervised temporal topic models to transform large corpora of news articles into temporal topic trends...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28098135/-outbreak-of-whooping-cough-in-2016-%C3%A3-cija-seville-spain
#5
Miguel Porras-Povedano, Ana Roldán-Garrido, Virginia Santacruz-Hamer
OBJECTIVE: Whooping cough is a global public health problem, is a highly contagious disease, and despite universal vaccination increased incidence is observed. The aim of this study was to describe the investigation of a population outbreak. METHODS: A descriptive study of a population outbreak of whooping cough between February and June 2016 in Ecija (Seville). Case and outbreak definitions was taken of Whooping Cough Monitoring Protocol. Information was collected from Health History, Epidemiological Monitoring System and Laboratory...
January 18, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28095485/bordetella-parapertussis-circumvents-neutrophil-extracellular-bactericidal-mechanisms
#6
Juan Gorgojo, Emilia Scharrig, Ricardo M Gómez, Eric T Harvill, Maria Eugenia Rodríguez
B. parapertussis is a whooping cough etiological agent with the ability to evade the immune response induced by pertussis vaccines. We previously demonstrated that in the absence of opsonic antibodies B. parapertussis hampers phagocytosis by neutrophils and macrophages and, when phagocytosed, blocks intracellular killing by interfering with phagolysosomal fusion. But neutrophils can kill and/or immobilize extracellular bacteria through non-phagocytic mechanisms such as degranulation and neutrophil extracellular traps (NETs)...
2017: PloS One
https://www.readbyqxmd.com/read/28091579/impact-of-age-and-vaccination-history-on-long-term-serological-responses-after-symptomatic-b-pertussis-infection-a-high-dimensional-data-analysis
#7
Inonge van Twillert, Axel A Bonačić Marinović, Betsy Kuipers, Jacqueline A M van Gaans-van den Brink, Elisabeth A M Sanders, Cécile A C M van Els
Capturing the complexity and waning patterns of co-occurring immunoglobulin (Ig) responses after clinical B. pertussis infection may help understand how the human host gradually loses protection against whooping cough. We applied bi-exponential modelling to characterise and compare B. pertussis specific serological dynamics in a comprehensive database of IgG, IgG subclass and IgA responses to Ptx, FHA, Prn, Fim2/3 and OMV antigens of (ex-) symptomatic pertussis cases across all age groups. The decay model revealed that antigen type and age group were major factors determining differences in levels and kinetics of Ig (sub) classes...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039663/whooping-cough-in-adults-a-series-of-severe-cases
#8
Katarzyna Zycinska, M Cieplak, M Chmielewska, A Nitsch-Osuch, A Klaczkow, M Hadzik-Blaszczyk, Z Kur, K A Wardyn
Bordetella pertussis is a gram-negative aerobic coccobacillus causing contagious respiratory tract disease called whooping cough. The virulence factors consist of pertussis toxin, filamentous hemagglutinin, fimbriae, lipooligosaccharide, and adenylate cyclase toxin. The disease causes a worldwide threat to public health despite a high vaccination coverage. The course of whooping cough in adults is frequently atypical, causing difficulty in diagnosis. In this report we present five patients hospitalized with Bordetella pertussis infection manifesting atypical and severe symptoms...
December 31, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28039302/camp-signaling-of-adenylate-cyclase-toxin-blocks-the-oxidative-burst-of-neutrophils-through-epac-mediated-inhibition-of-phospholipase-c-activity
#9
Ondrej Cerny, Karen E Anderson, Len R Stephens, Phillip T Hawkins, Peter Sebo
The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in immune evasion and virulence of the whooping cough agent Bordetella pertussis. CyaA penetrates the complement receptor 3-expressing phagocytes and ablates their bactericidal capacities by catalyzing unregulated conversion of cytosolic ATP to the key second messenger molecule cAMP. We show that signaling of CyaA-generated cAMP blocks the oxidative burst capacity of neutrophils by two converging mechanisms. One involves cAMP/protein kinase A-mediated activation of the Src homology region 2 domain-containing phosphatase-1 (SHP-1) and limits the activation of MAPK ERK and p38 that are required for assembly of the NADPH oxidase complex...
December 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27983896/how-often-people-google-for-vaccination-qualitative-and-quantitative-insights-from-a-systematic-search-of-the-web-based-activities-using-google-trends
#10
Nicola Luigi Bragazzi, Ilaria Barberis, Roberto Rosselli, Vincenza Gianfredi, Daniele Nucci, Massimo Moretti, Tania Salvatori, Gianfranco Martucci, Mariano Martini
Nowadays, more and more people surf the Internet seeking health-related information. Information and communication technologies (ICTs) can represent an important opportunities in the field of Public Health and vaccinology. The aim of our current research was to investigate a) how often people search the Internet for vaccination-related information, b) if this search is spontaneous or induced by media, and c) which kind of information is in particular searched. We used Google Trends (GT) for monitoring the interest for preventable infections and related vaccines...
February 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27974800/near-atomic-resolution-cryo-em-analysis-of-the-salmonella-t3s-injectisome-basal-body
#11
L J Worrall, C Hong, M Vuckovic, W Deng, J R C Bergeron, D D Majewski, R K Huang, T Spreter, B B Finlay, Z Yu, N C J Strynadka
The type III secretion (T3S) injectisome is a specialized protein nanomachine that is critical for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid fever, whooping cough, sexually transmitted infections and major nosocomial infections. This syringe-shaped 3.5-MDa macromolecular assembly spans both bacterial membranes and that of the infected host cell. The internal channel formed by the injectisome allows for the direct delivery of partially unfolded virulence effectors into the host cytoplasm...
December 14, 2016: Nature
https://www.readbyqxmd.com/read/27929206/acute-bronchitis
#12
Scott Kinkade, Natalie A Long
Cough is the most common illness-related reason for ambulatory care visits in the United States. Acute bronchitis is a clinical diagnosis characterized by cough due to acute inflammation of the trachea and large airways without evidence of pneumonia. Pneumonia should be suspected in patients with tachypnea, tachycardia, dyspnea, or lung findings suggestive of pneumonia, and radiography is warranted. Pertussis should be suspected in patients with cough persisting for more than two weeks that is accompanied by symptoms such as paroxysmal cough, whooping cough, and post-tussive emesis, or recent pertussis exposure...
October 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27922235/high-frequency-of-pertussis-in-older-children-and-adolescents-with-prolonged-cough-in-turkey
#13
Aslı Aslan, Zafer Kurugöl, Şöhret Aydemir, Derya Gürsel, Güldane Koturoğlu
This study aimed to determine the frequency of B. pertussis infection among Turkish children with prolonged cough. Nasopharyngeal specimens were collected from 7-18 year old children, presenting with prolonged cough of two to four weeks' duration. Specimens were examined for B. pertussis by PCR. Of 101 children with prolonged cough, 20 (19.8%) had a positive PCR testing for B. pertussis. Children who were vaccinated ≥5 years previously had a 6.13-fold higher risk of PCR-confirmed pertussis than those who were vaccinated < 5 years before...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27905535/bordetella-pertussis-outer-membrane-vesicle-vaccine-confers-equal-efficacy-in-mice-with-milder-inflammatory-responses-compared-to-a-whole-cell-vaccine
#14
René H M Raeven, Jolanda Brummelman, Jeroen L A Pennings, Larissa van der Maas, Wichard Tilstra, Kina Helm, Elly van Riet, Wim Jiskoot, Cécile A C M van Els, Wanda G H Han, Gideon F A Kersten, Bernard Metz
The demand for improved pertussis vaccines is urgent due to the resurgence of whooping cough. A deeper understanding of the mode of action of pertussis vaccines is required to achieve this improvement. The vaccine-induced effects of a candidate outer membrane vesicle vaccine (omvPV) and a classical protective but reactogenic whole cell vaccine (wPV) were comprehensively compared in mice. The comparison revealed essential qualitative and quantitative differences with respect to immunogenicity and adverse effects for these vaccines...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869387/-trends-in-pertussis-mortality-and-morbidity-in-colombia-2002-2012
#15
Doris Cardona, María Osley Garzón, Mateo Calle, Maite Catalina Agudelo, Ángela Segura
Whooping cough is a public health problem that mainly affects children under one year of age with highly lethal outcomes. It is a re-emerging disease, which is preventable by immunization. Objective: To analyze mortality and morbidity trends of whooping cough in Colombia between 2002 and 2012. Materials and methods: We conducted a quantitative descriptive study of deaths by pertussis between 2002 and 2012 using data from death certificates registered by the Departamento Administrativo Nacional de Estadística, and cases reported to the Sistema Nacional de Vigilancia en Salud Pública, 2005-2012...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27853066/concentrations-of-immunoglobulin-g-antibodies-against-pertussis-toxin-does-not-decrease-over-a-long-period-of-time-in-japan
#16
Yumi Sakakibara, Yoshio Ohtani, Torahiko Jinta, Toshihide Fujie, Yasunari Miyazaki, Naohiko Inase, Ryoichi Saito, Miho Akaza, Tetsuo Sasano, Yuki Sumi
Objective Adult patients with pertussis rarely show typical symptoms, such as paroxysmal coughing, inspiratory "whoop", or post-tussive vomiting. While a culture is regarded as the gold standard for diagnosis, the sensitivity is very low. Therefore, the diagnosis of pertussis in adults in clinical practice is mostly based on single-sample serology using an enzyme-linked immunosorbent assay (ELISA) with the pertussis toxin antigen. Various cut-off values for the anti-pertussis toxin IgG (PT-IgG) have been proposed...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27851884/pertussis-in-poland-in-2014
#17
Iwona Paradowska-Stankiewicz, Jolanta Rudowska
INTRODUCTION: In Poland, they are still recorded high number of cases whooping cough - five-year median for 2005-2009 and 2010-2014 are similar and amount to 5.2 and 5.5 per 100 000 population. The trend of the incidence of pertussis in a high percentage of adults that was observed in years between 2009-2011 (the results of the National Research Epidemiology of Pertussis), in subsequent years, ie. 2012-2014 was halted. Still the most effective strategy to prevent illness is the vaccination according to the current vaccination calendar...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27849178/modulation-of-pertussis-and-adenylate-cyclase-toxins-by-sigma-factor-rpoe-in-bordetella-pertussis
#18
Mariette Barbier, Dylan T Boehm, Emel Sen-Kilic, Claire Bonnin, Theo Pinheiro, Casey Hoffman, Mary Gray, Erik Hewlett, F Heath Damron
Bordetella pertussis is a human pathogen that can infect the respiratory tract and cause the disease known as whooping cough. B. pertussis uses pertussis toxin (PT) and adenylate cyclase toxin (ACT) to kill and modulate host cells to allow the pathogen to survive and persist. B. pertussis encodes many uncharacterized transcription factors, and very little is known about their functions. RpoE is a sigma factor which, in other bacteria, responds to oxidative, heat, and other environmental stresses. RseA is a negative regulator of RpoE that sequesters the sigma factor to regulate gene expression based on conditions...
January 2017: Infection and Immunity
https://www.readbyqxmd.com/read/27795930/a-plant-from-the-altiplano-of-northern-chile-senecio-nutans-inhibits-the-vibrio-cholerae-pathogen
#19
Adrian Paredes, Yanett Leyton, Carlos Riquelme, Glauco Morales
BACKGROUND: In the altiplano of Northern Chile the plant Senecio nutans is habitually used as an infusion to relieve the effects of altitude sickness (locally known as "puna"). It is also used to alleviate the bronchitis, whooping cough, asthma, stomachache, tiredness and fever. The extreme conditions under which these plant grow and scientific data that shows the inhibiting potential of the essential oils of plants of the genus Senecio represents great potential in the study of their application to control pathogens like Vibrio Cholera...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27795250/complete-genome-sequences-of-four-different-bordetella-sp-isolates-causing-human-respiratory-infections
#20
Michael R Weigand, Yanhui Peng, Vladimir Loparev, Dhwani Batra, Katherine E Bowden, Pamela K Cassiday, Jamie K Davis, Taccara Johnson, Phalasy Juieng, Christine E Miner, Lori Rowe, Mili Sheth, M Lucia Tondella, Margaret M Williams
Species of the genus Bordetella associate with various animal hosts, frequently causing respiratory disease. Bordetella pertussis is the primary agent of whooping cough and other Bordetella species can cause similar cough illness. Here, we report four complete genome sequences from isolates of different Bordetella species recovered from human respiratory infections.
October 6, 2016: Genome Announcements
keyword
keyword
3710
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"