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Conditioned place preference

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https://www.readbyqxmd.com/read/29330677/evaluating-efficacy-of-landsat-derived-environmental-covariates-for-predicting-malaria-distribution-in-rural-villages-of-vhembe-district-south-africa
#1
Oupa E Malahlela, Jane M Olwoch, Clement Adjorlolo
Malaria in South Africa is still a problem despite existing efforts to eradicate the disease. In the Vhembe District Municipality, malaria prevalence is still high, with a mean incidence rate of 328.2 per 100,0000 persons/year. This study aimed at evaluating environmental covariates, such as vegetation moisture and vegetation greenness, associated with malaria vector distribution for better predictability towards rapid and efficient disease management and control. The 2005 malaria incidence data combined with Landsat 5 ETM were used in this study...
January 12, 2018: EcoHealth
https://www.readbyqxmd.com/read/29318747/the-caudal-part-of-the-posterior-insula-of-rats-participates-in-the-maintenance-but-not-the-acquisition-of-morphine-conditioned-place-preference
#2
Yong-Mei Sun, Rong-Xiang Chen, Zhi-Fei Li, Sabine Spijker, Rong-Wei Zhai, Shang-Chuan Yang
The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively...
January 9, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29318708/cocaine-conditioned-place-preference-unexpected-suppression-of-preference-due-to-testing-combined-with-strong-conditioning
#3
Lucile Marion-Poll, Antoine Besnard, Sophie Longueville, Emmanuel Valjent, Olivia Engmann, Jocelyne Caboche, Denis Hervé, Jean-Antoine Girault
Conditioned place preference (CPP) is widely used for evaluating the rewarding effects of drugs. Like other memories, CPP is proposed to undergo reconsolidation during which it is unstable and sensitive to pharmacological inhibition. Previous studies have shown that cocaine CPP can be apparently erased by extracellular signal-regulated kinase (ERK) pathway inhibition during cocaine reconditioning (re-exposure to the drug-paired environment in the presence of the drug). Here, we show that blockade of D1 receptors during reconditioning prevented ERK activation and induced a loss of CPP...
January 10, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29317519/%C3%AE-arrestin-biased-%C3%AE-adrenergic-signaling-promotes-extinction-learning-of-cocaine-reward-memory
#4
Bing Huang, Youxing Li, Deqin Cheng, Guanhong He, Xing Liu, Lan Ma
Extinction learning of cocaine-associated contextual cues can help prevent cocaine addicts from relapsing. Pharmacological manipulation of β-adrenergic receptor (β-AR) during extinction learning is being developed as a potential strategy to treat drug addiction. We demonstrated that the extinction learning of cocaine-associated memory was mediated by β-arrestin2-biased but not heterotrimeric guanine nucleotide-binding protein (G protein)-dependent β-adrenergic signaling. We found that administration of the nonbiased β-AR antagonist propranolol, but not the G protein-biased β-AR antagonist carvedilol, blocked extinction learning of cocaine-conditioned place preference and the associated ERK activation in the infralimbic prefrontal cortex...
January 9, 2018: Science Signaling
https://www.readbyqxmd.com/read/29317484/chemogenetic-excitation-of-accumbens-projecting-infralimbic-cortical-neurons-blocks-toluene-induced-conditioned-place-preference
#5
Wesley N Wayman, John J Woodward
Abuse rates for inhalants among adolescents continue to be high, yet preclinical models for studying mechanisms underlying inhalant abuse remain limited. Our lab has previously shown that, in male rats, an acute binge-like exposure to toluene vapor that mimics human solvent abuse modifies the intrinsic excitability of medial prefrontal cortex (mPFC) pyramidal neurons projecting to the nucleus accumbens (NAc). These changes showed region (infralimbic; IL vs. prelimbic; PRL), layer (shallow; 2/3 vs. deep; 5/6), target (core vs...
January 9, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29305887/estradiol-enhances-ethanol-reward-in-female-mice-through-activation-of-er%C3%AE-and-er%C3%AE
#6
Elisa R Hilderbrand, Amy W Lasek
Alcohol use disorder (AUD) manifests differently in men and women, but little is known about sex differences in the brain's response to ethanol. It is known that the steroid hormone 17β-estradiol (E2) regulates voluntary ethanol consumption in female rodents. However, the role of E2 as a regulator of ethanol reward has not been investigated. In this study, we tested for the effects of E2 and agonists selective for the classical estrogen receptors, ERα and ERβ, on ethanol reward in ovariectomized (OVX) mice using the conditioned place preference (CPP) test...
January 3, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29301691/do-female-reproductive-stage-and-phenotype-influence-thermal-requirements-in-an-oviparous-lizard
#7
Guadalupe López Juri, Margarita Chiaraviglio, Gabriela Cardozo
Reproduction is an energetically costly activity that can alter thermal requirements in Squamata. This phenomenon has been largely studied in many viviparous species; however, little is known about the role of oviparous females in controlling temperature during vitellogenesis and embryo development before oviposition. Diversity of female phenotypes could be associated with diversity of thermoregulatory performance, since thermal requirements are frequently influenced by body shape. Furthermore, studying the thermoregulatory behaviour is fundamental to understand how females regulate their body temperature...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29299214/intervention-of-the-gamma-aminobutyric-acid-type-b-receptors-of-the-amygdala-central-nucleus-on-the-sensitivity-of-the-morphine-induced-conditionally-preferred-location-in-wistar-female-rats
#8
Firoozeh Alavian, Saeedeh Ghiasvand, Hedayat Sahraei, Maryam Rafiei-Rad
Background: The amygdala is one of the nerve centers involved in drug reward. It is suggested that the central nucleus of the amygdala (CeA) is involved in morphine dependency. The CeA gamma-aminobutyric acid-ergic (GABAergic) system is a mediator of morphine rewarding effects. In this research, the effects of stimulation or inhibition of CeA GABA type B (GABAB) receptors on sensitization acquisition to morphine-induced reward was evaluated in Wistar female rats using conditioned place preferential (CPP) method...
April 2017: Addiction & Health
https://www.readbyqxmd.com/read/29288746/a-new-synthetic-drug-5-2-aminopropyl-indole-5-it-induces-rewarding-effects-and-increases-dopamine-d1-receptor-and-dopamine-transporter-mrna-levels
#9
Chrislean Jun Botanas, Seong Shoon Yoon, June Bryan de la Peña, Irene Joy Dela Peña, Mikyung Kim, Raly James Custodio, Taeseon Woo, Joung-Wook Seo, Choon-Gon Jang, Ji Seul Yang, Yoon Mi Yoon, Yong Sup Lee, Hee Jin Kim, Jae Hoon Cheong
In recent years, there has been a marked increase in the use of recreational synthetic psychoactive substances, which is a cause of concern among healthcare providers and legal authorities. In particular, there have been reports on the misuse of 5-(2-aminopropyl)indole (5-API; 5-IT), a new synthetic drug, and of fatal and non-fatal intoxication. Despite these reports, little is known about its psychopharmacological effects and abuse potential. Here, we investigated the abuse potential of 5-IT by evaluating its rewarding and reinforcing effects through conditioned place preference (CPP) (1, 10, and 30 mg/kg, i...
December 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29283498/neuronal-rna-binding-protein-hud-regulates-addiction-related-gene-expression-and-behavior
#10
Robert J Oliver, Jonathan L Brigman, Federico Bolognani, Andrea M Allan, Janet L Neisewander, Nora I Perrone-Bizzozero
The neuronal RNA-binding protein HuD is involved in synaptic plasticity and learning and memory mechanisms. These effects are thought to be due to HuD-mediated stabilization and translation of target mRNAs associated with plasticity. To investigate the potential role of HuD in drug addiction, we first used bioinformatics prediction algorithms together with microarray analyses to search for specific genes and functional networks upregulated within the forebrain of HuD overexpressing mice (HuDOE ). When this set was further limited to genes in the Knowledgebase of Addiction Related Genes database (KARG) that contains predicted HuD-binding sites in their 3' untranslated regions (3' UTR), we found that HuD regulates networks that have been associated with addiction-like behavior...
December 28, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29273459/mirtazapine-impairs-acquisition-and-reinstatement-of-cocaine-induced-place-preference-in-rats
#11
Susana Barbosa-Méndez, Maura Matus-Ortega, Salomón Jacinto-Gutiérrez, Alberto Salazar-Juárez
Exposure to cues previously associated with drug use and the environment can trigger intense craving and drug-seeking, often leading to relapse in individuals with substance use disorders. Several studies suggest that the decrease in the effects of the cues and the environment could help maintain abstinence from drug use in individuals abusing drugs. Mirtazapine, an antagonist of the noradrenergic (NE) α2 receptor and the 5-HT2A/C and 5-HT3 receptors has demonstrated efficacy in reducing the rewarding effect of different drugs...
December 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29246771/antagonism-of-the-d1-and-d2-like-dopamine-receptors-in-the-nucleus-accumbens-attenuates-forced-swim-stress-and-morphine-priming-induced-reinstatement-of-extinguished-rats
#12
Zahra Farzinpour, Zahra Mousavi, Saeideh Karimi-Haghighi, Abbas Haghparast
Dopaminergic pathways from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) play a critical role in reward-related phenomena as well as in the reinstatement of drug-seeking behavior. Stress is a major trigger for inducing reinstatement, however, the interaction between stress and the dopaminergic system is not well known. The present study was undertaken to investigate the effect of D1- and D2-like dopamine receptors within the NAc in forced swim stress (FSS)- and priming-induced reinstatement of morphine-seeking behaviors...
December 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29242822/abstinence-from-cocaine-induced-conditioned-place-preference-produces-discrete-changes-in-glutamatergic-synapses-onto-deep-layer-5-6-neurons-from-prelimbic-and-infralimbic-cortices
#13
José I Pena-Bravo, Carmela M Reichel, Antonieta Lavin
Glutamatergic signaling in the medial prefrontal cortex (mPFC) plays a critical role in drug addiction and relapse. The mPFC is functionally subdivided into dorsal (prelimbic, PL) and ventral (infralimbic, IL) regions, and evidence suggests a differential role of these two divisions in the control of drug seeking and taking; however, there is a dearth of information on the cocaine-induced adaptations in PL- and IL-mPFC synaptic glutamate transmission and their regulation of behavioral responses to cocaine-associated stimuli...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29235927/risk-factors-for-hospital-death-in-conditions-needing-palliative-care-nationwide-population-based-death-certificate-study
#14
Barbara Gomes, Maria João Pinheiro, Sílvia Lopes, Maja de Brito, Vera P Sarmento, Pedro Lopes Ferreira, Henrique Barros
BACKGROUND: Most people would prefer to die at home as opposed to hospital; therefore, understanding mortality patterns by place of death is essential for health resources allocation. AIM: We examined trends and risk factors for hospital death in conditions needing palliative care in a country without integrated palliative care. DESIGN: This is a death certificate study. We examined factors associated with hospital death using logistic regression...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29227676/studying-sex-differences-in-animal-models-of-addiction-an-emphasis-on-alcohol-related-behaviors
#15
Elisa R Hilderbrand, Amy W Lasek
Animal models are essential for understanding the biological factors that contribute to drug and alcohol addiction and discovering new pharmacotherapies to treat these disorders. Alcohol (ethanol) is the most commonly abused drug in the world, and as the prevalence of alcohol use disorder (AUD) increases, so does the need for effective pharmacotherapies. In particular, treatments with high efficacy in the growing number of female AUD sufferers are needed. Female animals remain underrepresented in biomedical research and sex differences in the brain's response to alcohol are poorly understood...
December 11, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29226464/place-of-death-in-the-snowy-monaro-region-of-new-south-wales-a-study-of-residents-who-died-of-a-condition-amenable-to-palliative-care
#16
Suzanne Rainsford, Nicholas J Glasgow, Rod D MacLeod, Teresa Neeman, Christine B Phillips, Robert B Wiles
OBJECTIVE: To describe the place of death of residents in a rural region of New South Wales. DESIGN: Cross-sectional quantitative study using death data collected from local funeral directors (in person and websites), residential aged-care facilities, one multipurpose heath service and obituary notices in the local media (newspapers/radio). SETTING: Snowy Monaro region (NSW Australia). PARTICIPANTS: Residents, with advanced frailty or one of 10 conditions amenable to palliative care, who died between 1 February 2015 and 31 May 2016...
December 11, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29226221/male-and-female-residents-in-postgraduate-medical-education-a-gender-comparative-analysis-of-differences-in-career-perspectives-and-their-conditions-in-germany
#17
Stine Ziegler, Thomas Zimmermann, Lea Krause-Solberg, Martin Scherer, Hendrik van den Bussche
Aim: This article focuses on the gender-specific career differences of residents in their postgraduate medical education in Germany. In particular the structural obstacles female physicians have to overcome during residency are investigated. Moreover, the study examines the position preferences of male and female physicians in the hospital and in how far occupational self-efficacy corresponds to the interest in a hospital leading position. Methods: The KarMed-Study's database consists of annual postal surveys throughout the entire residency of medical students, who were in their "Practical Year" in 2008/2009...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/29217682/overexpression-of-the-histone-dimethyltransferase-g9a-in-nucleus-accumbens-shell-increases-cocaine-self-administration-stress-induced-reinstatement-and-anxiety
#18
Ethan M Anderson, Erin B Larson, Daniel Guzman, Anne Marie Wissman, Rachael L Neve, Eric J Nestler, David W Self
Repeated exposure to cocaine induces lasting epigenetic changes in neurons that promote the development and persistence of addiction. One epigenetic alteration involves reductions in levels of the histone dimethyltransferase, G9a, in nucleus accumbens (NAc) after chronic cocaine administration. This reduction in G9a may enhance cocaine reward since overexpressing G9a in the NAc decreases cocaine-conditioned place preference. Thus, we hypothesized that HSV-mediated G9a overexpression in the NAc shell (NAcSh) would attenuate cocaine self-administration and cocaine-seeking behavior...
December 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29216351/1-adrenoceptor-in-the-central-amygdala-is-required-for-unconditioned-stimulus-induced-drug-memory-reconsolidation
#19
Huiwen Zhu, Yiming Zhou, Zhiyuan Liu, Xi Chen, Yanqing Li, Xing Liu, Lan Ma
Background: Drug memories become labile and reconsolidated after retrieval by presentation of environmental cues (conditioned stimulus, CS) or drugs (unconditioned stimulus, US). Whether CS- and US-retrieval trigger different memory reconsolidation processes is not clear. Methods: Protein synthesis inhibitor or β-AR antagonist was systemically administrated or intra-central amygdala (CeA) infused immediately after cocaine re-exposure in cocaine-conditioned place preference (CPP) or self-administration (SA) mice models...
December 5, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29215166/effectiveness-of-platelet-rich-plasma-therapy-in-wound-healing-of-pilonidal-sinus-surgery-a-comprehensive-systematic-review-and-meta-analysis
#20
Shayan Mostafaei, Fatemeh Norooznezhad, Saeed Mohammadi, Amir Hossein Norooznezhad
BACKGROUND: Pilonidal disease (PD) is a chronic situation which may cause pain, discomfort, inflammation, discharges, and inability to do daily routines. Among two main methods of surgery, open healing is preferred by surgeons since it associates with lower risk of recurrence; however, it could complicate the wound condition by delaying the healing process. METHODS: For this meta-analysis, a search in Medline, Embase and Scopus was performed in June 2017 with no restrictions placed on the publication date or languages...
December 7, 2017: Wound Repair and Regeneration
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