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post hysterectomy ovarian cancer

Daisy B Hassani, Jeffrey M Mangel, Sangeeta T Mahajan, Adonis K Hijaz, Sherif El-Nashar, David Sheyn
INTRODUCTION AND HYPOTHESIS: Opportunistic salpingectomy (OS) at the time of benign hysterectomy has recently emerged as a potential primary preventive modality for ovarian cancer. Our objective was to determine whether the reported rate of OS at the time of prolapse surgery is similar to the rate of OS at the time of gynecologic surgery for non-prolapse indications. METHODS: An anonymous online survey was sent to the Society of Gynecologic Surgery members. Responses were divided into surgeons who did and did not perform OS at the time of prolapse repair...
April 14, 2018: International Urogynecology Journal
Danielle D Antosh, Rachel High, Heidi W Brown, Sallie S Oliphant, Husam Abed, Nisha Philip, Cara L Grimes
BACKGROUND: The American Congress of Obstetricians and Gynecologists recommends that "the surgeon and patient discuss the potential benefits of the removal of the fallopian tubes during a hysterectomy in women at population risk of ovarian cancer who are not having an oophorectomy," resulting in an increasing rate of salpingectomy at the time of hysterectomy. Rates of salpingectomy are highest for laparoscopic and lowest for vaginal hysterectomy. OBJECTIVE: The primary objective of this study was to determine the feasibility of bilateral salpingectomy at the time of vaginal hysterectomy...
November 2017: American Journal of Obstetrics and Gynecology
Renée T Fortner, Allison F Vitonis, Helena Schock, Anika Hüsing, Theron Johnson, Raina N Fichorova, Titilayo Fashemi, Hidemi S Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Giuseppe Matullo, Amalia Mattiello, N Charlotte Onland-Moret, Petra H Peeters, Elisabete Weiderpass, Inger Torhild Gram, Mie Jareid, J Ramón Quirós, Eric J Duell, Maria-Jose Sánchez, María Dolores Chirlaque, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Jenny Brändstedt, Annika Idahl, Kay-Tee Khaw, Naomi Allen, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A Merritt, Elio Riboli, Daniel W Cramer, Rudolf Kaaks, Kathryn L Terry
BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases)...
March 20, 2017: Journal of Ovarian Research
Hidetaka Nomura, Nobuhiro Takeshima
The cumulative risks of developing epithelial ovarian cancer in women aged 70-75years with BRCA1 and BRCA2 germline mutations are approximately 39-40% and 11-18%, respectively. Here, we present the management of hereditary breast and ovarian cancer(HBOC)in our hospital. HBOC management commences with the selection of appropriate candidates for genetic testing, based on personal and familial characteristics that determine the individual's probability of being a mutation carrier. Pre-test counseling, which is an essential element of genetic counseling, should include discussion of why the test is being offered, how the test results may affect medical management, and the cancer risks associated with the gene mutation...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Jemma Mytton, Felicity Evison, Peter J Chilton, Richard J Lilford
OBJECTIVE:  To conduct a nationwide study of associations between removal of all ovarian tissue versus conservation of at least one ovary at the time of hysterectomy and important health outcomes (ischaemic heart disease, cancer, and all cause mortality). STUDY DESIGN AND SETTING:  Retrospective analysis of the English Hospital Episode Statistics database linked to national registers of deprivation indices and of deaths. PARTICIPANTS:  113 679 patients aged 35-45 who had had a hysterectomy for benign conditions between April 2004 and March 2014...
February 6, 2017: BMJ: British Medical Journal
Ling Chen, Soledad Jorge, William M Burke, Ana Tergas, June Hou, Jim Hu, Alfred I Neugut, Cande Ananth, Dawn L Hershman
62 Background: Extended-duration thromboprophylaxis for 4 weeks after discharge has been demonstrated to reduce venous thromboembolic events (VTE) in cancer patients undergoing abdominopelvic surgery and is recommended in national guidelines. We examined the utilization and effectiveness of extended-duration low molecular weight heparin prophylaxis in high-risk cancer patients after surgery. METHODS: We analyzed patients with colon, ovarian, and uterine cancer who underwent surgery from 2009-2013 and who were recorded in the MarketScan database...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Gillian Elizabeth Hanley, Jessica Nell McAlpine, Celeste Leigh Pearce, Dianne Miller
BACKGROUND: Ovarian cancer is the leading cause of death due to gynecologic malignancy and the fifth most common cause of cancer deaths in developed countries. Recent evidence has indicated that the most common and lethal form of ovarian cancer originates in the distal fallopian tube, and recommendations for surgical removal of the fallopian tube (bilateral salpingectomy) at the time of other gynecologic surgeries (particularly hysterectomy and tubal sterilization) have been made, most recently by the American Congress of Obstetricians and Gynecologists...
March 2017: American Journal of Obstetrics and Gynecology
Juhua Luo, Michael Hendryx, JoAnn E Manson, XiaoYun Liang, Karen L Margolis
CONTEXT: Estrogen has been suggested as a risk factor for thyroid cancer. OBJECTIVE: The aim of this study is to examine the associations between hysterectomy, bilateral salpingo-oophorectomy (BSO), and incidence of thyroid cancer. DESIGN: This was a prospective cohort study. SETTING: The study was conducted at 40 clinical centers in the United States. PARTICIPANTS: A total of 127 566 women aged 50-79 were enrolled in the Women's Health Initiative during 1993-1998...
October 2016: Journal of Clinical Endocrinology and Metabolism
Anne Craveiro Brøchner, Søren Mikkelsen, Iørn Hegelund, Marianne Hokland, Ole Mogensen, Palle Toft
INTRODUCTION: The treatment of women with ovarian cancer in advanced stages consists of extensive surgery followed by chemotherapy initiated three weeks after surgery. In this study, selected immune parameters were investigated to elucidate when the immune system is normalised following the operation. METHODS: Ten women undergoing extensive surgery for ovarian cancer were compared with a control group of ten women undergoing abdominal hysterectomy for a benign diagnosis...
June 2016: Danish Medical Journal
Brandon T Sawyer, Christopher J LaFargue, Robert E Bristow
OBJECTIVE: The completeness of primary cytoreductive surgery for Stage IV epithelial ovarian cancer is associated with greater progression free survival and overall survival Winter et al. (2008) [1]. Cytoreduction to no gross residual disease in patients with bulky upper abdominal disease presents significant surgical challenges, highlighting the importance of specialized and comprehensive surgical training in the treatment of advanced ovarian cancers Zivanovic et al. (2008) [2]. Extensive upper abdominal surgical procedures have shown to improve the ability to achieve cytoreduction to no gross residual disease Chi et al...
August 2016: Gynecologic Oncology
Jason D Wright, Ling Chen, Soledad Jorge, William M Burke, Ana I Tergas, June Y Hou, Jim C Hu, Alfred I Neugut, Cande V Ananth, Dawn L Hershman
OBJECTIVE: Extended-duration thromboprophylaxis for 4weeks after discharge has been demonstrated to reduce venous thromboembolic events (VTE) in cancer patients undergoing abdominopelvic surgery and is recommended in national guidelines. We examined the utilization and effectiveness of extended-duration low molecular weight heparin prophylaxis in high-risk cancer patients. METHODS: We analyzed patients with colon, ovarian, and uterine cancer who underwent surgery from 2009 to 2013 and who were recorded in the MarketScan database...
June 2016: Gynecologic Oncology
Benito Chiofalo, Jacopo Di Giuseppe, Lara Alessandrini, Tiziana Perin, Giorgio Giorda, Vincenzo Canzonieri, Francesco Sopracordevole
BACKGROUND: Three primary synchronous cancers in the female genital tract are extremely rare. In the literature, only four studies have described three different invasive gynecologic cancers of epithelial origin identified simultaneously in the same patient. CASE PRESENTATION: This is the first case in the literature that reports on triple primary ovarian, endometrial and endocervical cancers in a 38-year-old woman with a history of previously treated malignant disease (acute lymphatic leukemia)...
June 2016: Pathology, Research and Practice
Salvatore Gueli Alletti, Carolina Bottoni, Francesco Fanfani, Valerio Gallotta, Vito Chiantera, Barbara Costantini, Francesco Cosentino, Alfredo Ercoli, Giovanni Scambia, Anna Fagotti
BACKGROUND: Laparoscopy has acquired an increasing role in the management of ovarian cancer. Laparoscopic cytoreduction could represent a new frontier for selected patients after neoadjuvant chemotherapy (NACT). OBJECTIVE: We sought to assess feasibility and early complication rate of minimally invasive (MI) interval debulking surgery (IDS) in stage III-IV epithelial ovarian cancer (EOC) patients after NACT. STUDY DESIGN: This is a phase II multicentric study in advanced EOC cases with clinical complete response after NACT, according to Gynecologic Cancer Intergroup and Response Evaluation Criteria In Solid Tumors criteria...
April 2016: American Journal of Obstetrics and Gynecology
L Cobellis, M A Castaldi, V Frega, L Mosca, F Corvino, S Cappabianca, N Colacurci
PURPOSE OF INVESTIGATION: Miillerian anomalies have not been implicated as a significant risk factor for the development of cervical, uterine, and ovarian cancers; in the present literature, there are only a few reports of endometrial cancer arising in patients with Miillerian abnormalities. To the best of the authors' knowledge, this is the first reported case of endometrial cancer arising in a patient with unicornuate uterus. CASE REPORT: A 69-year-old Caucasian woman underwent clinical examination and office hysteroscopy with endometrial biopsy because of abnormal post-menopausal bleeding...
2015: European Journal of Gynaecological Oncology
Jessica L Chan, Joseph Letourneau, Wael Salem, Aylin Pelin Cil, Sai-Wing Chan, Lee-May Chen, Mitchell P Rosen
OBJECTIVE: To determine if sexual satisfaction and sexual quality of life (QOL) are different in survivors of localized cervical and ovarian cancers who undergo fertility-sparing surgery (FSS) as compared with standard surgery. METHODS: 470 survivors of localized cervical and ovarian cancers diagnosed between the ages of 18-40 were recruited from the California Cancer Registry to complete a cross-sectional survey. Validated questionnaires were used to assess sexual satisfaction and sexual QOL...
October 2015: Gynecologic Oncology
Xiaqin Zhu, Ming Wu, Xianjie Tan, Qi Yu
OBJECTIVE: To explore the clinicopathologic features, managements and outcomes of villoglandular adenocarcinoma (VA) of uterine cervix. METHODS: From June 2009 to January 2014, a total of 16 cases of VA were reviewed retrospectively. RESULTS: Their mean age was 41.4 (30-56) years. The major symptoms were post-coital hemorrhage or abnormal vaginal hemorrhage (10/16). And the International Federation of Gynecology and Obstetrics (FIGO) stages were Ia1 (n = 1),Ib1 (n = 12),Ib2 (n = 2) and IIa1 (n = 1)...
February 17, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Magali Robert, David Cenaiko, Jasmine Sepandj, Stanislaw Iwanicki
STUDY OBJECTIVES: To document the success rates and complications of salpingectomy performed at the time of vaginal hysterectomy to possibly reduce ovarian cancer rates. DESIGN: Retrospective cohort study (Canadian Task Force Classification II-2). SETTING: Community-based hospital with university affiliation in Calgary, Canada. INTERVENTION: All women undergoing hysterectomy for benign conditions were offered preferentially a vaginal approach with prophylactic salpingectomy...
July 2015: Journal of Minimally Invasive Gynecology
Katsunori Ami, Kentarou Gokita, Yousuke Kawai, Yutarou Matsunaga, Keiichi Fujiya, Nana Ohshima, Hidetoshi Amagasa, Hideaki Ganno, Kenichirou Imai, Akira Fukuda, Takeshi Nagahama, Masayuki Ando, Youichi Okada, Hidetaka Akita, Shikofumi Tei, Yousuke Yamada, Mariko Takagi, Fumi Kodaka, Kuniyoshi Arai
Stage IV gastric cancer has poor prognosis, and median survival time (MST) is reported to range from 6 to 13 months. We report a case of long-term survival in a Stage IV gastric cancer patient who was successfully treated with multi combination chemotherapy with S-1. A 73-year-old woman presenting with gastric cancer with pyloric stenosis and peritoneal dissemination at the sigmoid colon underwent distal gastrectomy with D2 lymphadenectomy and sigmoidectomy. She received adjuvant chemotherapy with S-1 and CDDP after surgery...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Avanish Kumar Saxena, Nitin Goyal, Juhi Singhal, Parveen Kumar
Axillary lymph node metastasis from primary ovarian cancer is rare. Here, we reporting a unique case of 45 years old who presented with axillary lymph node metastasis which was thought from breast carcinoma but it turned out to be due to ovarian serous adenocarcinoma confirmed by histopathology & immunohistochemistry. Staging laparotomy (IIIc) with hysterectomy with bilateral salpingo-oophorectomy was done. Post-operatively, the patient was given adjuvant chemotherapy. No local or systemic recurrence was noted during 1 year follow up period...
September 2014: Indian Journal of Surgical Oncology
Ramona Moldovan, Sianan Keating, Tara Clancy
Women with Lynch syndrome (LS) have a significantly increased lifetime risk of endometrial cancer (40-60 %) and ovarian cancer (7-12 %). Currently there is little evidence to support the efficacy of screening for the early detection of these cancers. Another option is risk-reducing hysterectomy and/or bilateral salpingo-oophorectomy (BSO). Research on the impact of BSO in premenopausal women with a non-LS associated family history cancer has generally shown that women have a high level of satisfaction about their decision to undergo surgery...
March 2015: Familial Cancer
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