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https://www.readbyqxmd.com/read/27884774/esponsive-multifunctional-drug-delivery-nanoparticles-for-elastic-matrix-regenerative-repair
#1
Balakrishnan Sivaraman, Ganesh Swaminathan, Lee Moore, Jonathan Fox, Dhruv Seshadri, Shataakshi Dahal, Ivan Stoilov, Maciej Zborowski, Robert Mecham, Anand Ramamurthi
: Arresting or regressing growth of abdominal aortic aneurysms (AAAs), localized expansions of the abdominal aorta are contingent on inhibiting chronically overexpressed matrix metalloproteases (MMPs)-2 and -9 that disrupt elastic matrix within the aortic wall, concurrent with providing a stimulus to augmenting inherently poor auto-regeneration of these matrix structures. In a recent study we demonstrated that localized, controlled and sustained delivery of doxycycline (DOX; a tetracycline-based antibiotic) from poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs), enhances elastic matrix deposition and MMP-inhibition at a fraction of the therapeutically effective oral dose...
November 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27801400/-surgical-treatment-of-distal-extracranial-internal-carotid-artery-aneurysms-associated-with-pathological-artery-kinking
#2
V E Guzhin, A V Dubovoi, A V Cherepanov
Extracranial internal carotid artery (ICA) aneurysms located at the entrance of the skull are a rare pathology. Surgical treatment is indicated for this pathology because of the risk of arterio-arterial embolism and the development of cerebrovascular disease. The domestic and international literature reports single cases or small group cases of successful surgical treatment of patients with distal internal carotid artery aneurysms associated with pathological kinking of the artery. Open surgery for aneurysms of this localization is complicated because of a high injury risk associated with the approach...
2016: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/27755418/magnetic-resonance-imaging-and-magnetic-resonance-angiography-findings-of-external-carotid-artery-aneurysm-and-coexisting-carotid-body-tumor
#3
Vahit Mutlu, Hayri Ogul
Carotid body tumors originate from paraganglionic tissue in the bifurcation of the common carotid artery. Magnetic resonance imaging is a frequently used diagnostic method in the preoperative diagnosis of these tumors and provides appropriate information for surgical planning. In this study, the authors emphasize magnetic resonance imaging and magnetic resonance angiography findings of the external carotid artery aneurysm associated with carotid body tumor. This highlights that the diagnosis of carotid artery aneurysms is essential to avoid accidental injury to the vessel during tumor surgery...
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27738575/onyx-embolization-of-a-meningioma-with-a-dysplastic-aneurysmal-anterior-cerebral-artery-vessel
#4
Daniel R Felbaum, Kyle Mueller, Ai-Hsi Liu, Rocco A Armonda
Preoperative embolization of meningiomas can be safely performed using a variety of embolic agents. Most commonly, the vascular supply from branches of the external carotid artery is the target of embolization. In our report, we detail the treatment of a patient with a parafalcine meningioma that received its supply via branches of the anterior cerebral artery. One of the feeder vessels appeared to contain a dysplastic aneurysmal dilatation of the vessel. Due to patient circumstances, embolization was performed using standard microcatheterization techniques to minimize intraoperative blood loss...
September 11, 2016: Curēus
https://www.readbyqxmd.com/read/27671095/long-term-follow-up-for-a-giant-basilar-trunk-aneurysm-surgically-treated-by-proximal-occlusion-and-external-carotid-artery-to-posterior-cerebral-artery-bypass-using-a-saphenous-vein-graft
#5
Toshiharu Yanagisawa, Hiroyuki Kinouchi, Toshio Sasajima, Hiroaki Shimizu
The authors describe a case of a basilar trunk aneurysm with long-term follow-up after successful bypass and proximal occlusion. A 64-year-old woman had a giant aneurysm of the basilar trunk and underwent external carotid artery-to-posterior cerebral artery vein graft bypass surgery and proximal clipping of the basilar artery, which was followed by low-dose aspirin (100 mg/d) treatment. No ischemic symptoms and lesions developed and the thrombosed aneurysm was stable during 11 years of follow-up. An extracranial-intracranial high flow bypass combined with immediate proximal occlusion and aspirin administration may be an acceptable treatment option for patients with giant posterior circulation aneurysms...
September 23, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27637632/emergency-non-occlusive-high-capacity-bypass-surgery-for-ruptured-giant-internal-carotid-artery-aneurysms
#6
Jan-Karl Burkhardt, Giuseppe Esposito, Jorn Fierstra, Oliver Bozinov, Luca Regli
AIM: Managing ruptured giant internal carotid artery (ICA) aneurysms in an emergency situation is very challenging. By reporting two cases, we discuss the role of the Excimer Laser-assisted Non-occlusive Anastomosis (ELANA) technique as an armamentarium for cerebrovascular surgeons dealing with giant ICA aneurysms presenting with subarachnoid hemorrhage (SAH). MATERIALS AND METHODS: The management of two consecutive patients treated with ELANA bypass during a 6-month period (June- December 2013) for ruptured giant ICA aneurysms in an emergency setting is presented...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27637628/retrograde-suction-decompression-through-direct-puncture-of-the-common-carotid-artery-for-paraclinoid-aneurysm
#7
Naoki Otani, Kojiro Wada, Terushige Toyooka, Kazuya Fujii, Hideaki Ueno, Satoshi Tomura, Arata Tomiyama, Yasuaki Nakao, Takuji Yamamoto, Kentaro Mori
BACKGROUND: Surgical clipping of paraclinoid aneurysm can be very difficult because strong adhesions may hinder the dissection of the perforators and surrounding anatomical structures from the aneurysm dome. We describe our experience with using retrograde suction decompression during the clipping of paraclinoid aneurysms and discuss the relative advantages and pitfalls. MATERIALS AND METHODS: This study included 23 patients with large and giant paraclinoid aneurysms who underwent surgical treatment consisting of direct clipping with suction decompression between March 2004 and August 2014...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27518244/ruptured-left-external-carotid-artery-aneurysm-presenting-as-upper-airway-obstruction-in-von-recklinghausen-s-disease
#8
Hajar Souldi, Mohammed Yahya Bajja, Meriem Chenguir, RedaLah Abada, Samy Rouadi, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder characterized by café-au-lait macules, neurofibromas, and iris hamartomas. Carotid artery aneurysms rarely affect patients with NF-1 but may be associated with rupture. We report the first episode of a ruptured external carotid aneurysm with severe life-threatening airway obstruction in a NF-1 patient. PRESENTATION OF CASE: We report a case of NF-1 32-year-old woman admitted to our department for life-threatening upper airway obstruction caused by spontaneous expanding swelling in the left sided neck...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27468662/aspirin-and-clopidogrel-inhibit-aneurysm-healing-after-hydrocoil-implantation-in-external-carotid-artery-aneurysm-model
#9
Chao Zhang, Peiliang Li, Guohua Xi, Joseph J Gemmete, Neeraj Chaudhary, B Gregory Thompson, Aditya S Pandey
PURPOSE: To understand whether the use of antiplatelet agents leads to less intra-aneurismal tissue formation following coil implantation in a rat end-pouch external carotid artery (ECA) aneurysm model. METHODS: End-pouch ECA aneurysms were created in adult rats and were then embedded with either platinum or HydroCoils. Rats were treated either with aspirin, clopidogrel, aspirin + clopidogrel, or saline for 2 weeks after coil implantation. At 2 weeks after coil implantation, rats were sacrificed and the aneurysm pouch was removed for histological and immunohistochemical analysis...
July 25, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27466463/separate-origins-of-the-left-internal-and-external-carotid-arteries-from-the-aortic-arch-and-cervical-internal-carotid-artery-aneurysm-in-a-patient-with-noonan-syndrome
#10
Rizwan Ahmad Tahir, Karam Asmaro, Aqueel Pabaney, Max Kole, Timothy Nypaver, Horia Marin
Distinct origins of the external carotid artery and the internal carotid artery (ICA) from the aortic arch have been rarely described, and represent an aberrant development of the aortic arches during fetal life. This anatomical variation is usually discovered incidentally; infrequently, an aneurysm of the cervical ICA might accompany this rare configuration. We describe one such case in a patient with Noonan syndrome who presented with pulsatile neck mass. The diagnostic features and management of the aneurysm and a review of the literature are presented...
July 27, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27440846/separate-origins-of-the-left-internal-and-external-carotid-arteries-from-the-aortic-arch-and-cervical-internal-carotid-artery-aneurysm-in-a-patient-with-noonan-syndrome
#11
Rizwan Ahmad Tahir, Karam Asmaro, Aqueel Pabaney, Max Kole, Timothy Nypaver, Horia Marin
Distinct origins of the external carotid artery and the internal carotid artery (ICA) from the aortic arch have been rarely described, and represent an aberrant development of the aortic arches during fetal life. This anatomical variation is usually discovered incidentally; infrequently, an aneurysm of the cervical ICA might accompany this rare configuration. We describe one such case in a patient with Noonan syndrome who presented with pulsatile neck mass. The diagnostic features and management of the aneurysm and a review of the literature are presented...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27430582/external-carotid-compression-a-novel-technique-to-improve-cerebral-perfusion-during-selective-antegrade-cerebral-perfusion-for-aortic-arch-surgery
#12
Hilary P Grocott, Emma Ambrose, Mike Moon
PURPOSE: Selective antegrade cerebral perfusion (SACP) involving cannulation of either the axillary or innominate artery is a commonly used technique for maintaining cerebral blood flow (CBF) during the use of hypothermic cardiac arrest (HCA) for operations on the aortic arch. Nevertheless, asymmetrical CBF with hypoperfusion of the left cerebral hemisphere is a common occurrence during SACP. The purpose of this report is to describe an adjunctive maneuver to improve left hemispheric CBF during SACP by applying extrinsic compression to the left carotid artery...
October 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27421193/lemierre-s-syndrome-associated-mycotic-aneurysm-of-the-external-carotid-artery-with-primary-internal-carotid-artery-occlusion-in-a-previously-healthy-18-year-old-female
#13
Khalil H Chamseddin, Melissa L Kirkwood
Lemierre's syndrome is a rare life threatening condition characterized by internal jugular vein thrombosis, and is typically associated with a gram negative infection with septic metastasis secondary to a retropharyngeal abscess that involves the vasculature of the head and neck. We report a case of Lemierre's syndrome in an 18-year-old female adolescent who developed an internal carotid artery occlusion and ipsilateral external carotid artery mycotic aneurysm complicated by fulminant pseudomonal sepsis. The patient was managed with open ligation of the external carotid artery with essentially complete recovery...
July 12, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27403218/lingual-artery-retromandibular-vein-fistula-four-years-after-an-uncomplicated-carotid-endarterectomy-case-report-and-review-of-possible-etiologies-and-treatment-options
#14
Sunil Manjila, Kunal Kumar, Ashish Kulhari, Gagandeep Singh, Richard S Jung, Robert W Tarr, Nicholas C Bambakidis
The external carotid artery's lingual branch to retromandibular venous fistula following a carotid endarterectomy has not been reported earlier in literature. We report a unique case of an 87-year-old man who had a right-sided carotid endarterectomy in 2009 and presented four years later with complaints of fullness and discomfort in the area of right parotid gland with associated pulsatile tinnitus. A computed tomography (CT) scan of the neck revealed a deep portion of the right parotid gland having abnormal aneurysmal dilatation of a vascular structure, which appeared to be an arteriovenous fistula between branches of right external carotid artery and the retromandibular vein...
June 2016: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/27384116/-a-novel-less-invasive-protection-method-for-carotid-artery-stenting
#15
Tomotaka Ohshima, Shunsaku Goto, Taiki Yamamoto, Tasuku Imai, Toshihisa Nishizawa, Shinji Shimato, Kyozo Kato
<i>Purpose</i>: We present a novel, less invasive protection method for carotid artery stenting. <i>Case presentation</i>: A 67-year-old man presented with symptomatic severe left carotid artery stenosis. A transfemoral approach was dangerous because of an abdominal aortic aneurysm. A 6Fr Axcelguide Simmonds catheter was inserted into the right brachial artery, and advanced into the left common carotid artery. Next, a 6Fr Optimo 100-cm catheter was coaxially navigated into the left common carotid artery...
July 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27334736/temporal-aneurysmal-bone-cyst-cost-effective-method-to-achieve-gross-total-resection
#16
Harsimrat Bir Singh Sodhi, Pravin Salunke, Parimal Agrawal, Kirti Gupta
Aneurysmal bone cyst (ABC) is a vascular benign bony expansile lesion. The treatment is gross total resection. Surgery for a skull base aneurysmal bone cyst poses a significant challenge because of its vascularity and the adjacent neurovascular structures. We present the case of a young male with a temporal aneurysmal bone cyst who underwent gross total resection of the lesion. The external carotid artery (ECA) was temporarily clamped to cut off the vascular supply. There was no intraoperative event, and the patient made a good postoperative clinical recovery...
August 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27259917/tailored-flow-sequestration-treatment-using-high-flow-and-low-flow-bypass-for-partially-thrombosed-giant-internal-carotid-artery-aneurysm-a-technical-case-report
#17
Hirotaka Hasegawa, Tomohiro Inoue, Akira Tamura, Isamu Saito
Direct clipping of giant partially thrombosed intracranial internal carotid artery (ICA) aneurysms is challenging, especially when important perforating arteries are involved. Proximal occlusion with bypass represents a possible alternative approach. An 80-year-old female presented with worsening visual acuity and severe headache caused by partially thrombosed giant (38 mm in diameter) aneurysms of the right ICA, suggestive of impending rupture. Direct clipping in conjunction with temporary occlusion of the lesion involving the anterior choroidal artery (AChA) was considered too risky...
October 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27258767/blister-aneurysms-of-the-internal-carotid-artery-microsurgical-results-and-management-strategy
#18
Christopher M Owen, Nicola Montemurro, Michael T Lawton
BACKGROUND: Blister aneurysms of the supraclinoid internal carotid artery (ICA) are challenging lesions with high intraoperative rupture rates and significant morbidity. An optimal treatment strategy for these aneurysms has not been established. OBJECTIVE: To analyze treatment strategy, operative techniques, and outcomes in a consecutive 17-year series of ICA blister aneurysms treated microsurgically. METHODS: Seventeen patients underwent blister aneurysm treatment with direct clipping, bypass and trapping, or clip-reinforced wrapping...
June 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/27256171/four-dimensional-computed-tomography-angiography-demonstrating-a-ruptured-basilar-artery-aneurysm-causing-anterior-cerebral-circulation-arrest
#19
Hans G J Kortman, Hieronymus D Boogaarts, Mathias Prokop, Frederick J A Meijer
A 61-year-old woman suffered a pronounced subarachnoid hemorrhage. Conventional computed tomography angiography (CTA) showed no enhancement of the intracranial vasculature, whereas there was normal contrast enhancement of bilateral external carotid artery branches. Subsequent four-dimensional computed tomography angiography (4D-CTA) demonstrated active contrast leakage out of a ruptured basilar tip aneurysm, whereas there was no enhancement of the anterior circulation at any time point, consistent with intracranial anterior circulation arrest...
September 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27091873/congenital-absence-of-internal-carotid-artery-with-intercavernous-anastomosis-case-report-and-systematic-review-of-the-literature
#20
REVIEW
Ibrahim Ilker Oz, Ismail Serifoglu, Omer Yazgan, Zuhal Erdem
The absence of an internal carotid artery is a rare congenital anomaly. In the absence of the internal carotid artery, collateral circulations develop through the circle of Willis, persistent embryonic arteries or transcranial collaterals of the external carotid artery. Six pathways of collateral circulation have been described. Intercavernous anastomosis is between cavernous segments of the bilateral internal carotid arteries and is rarely seen. Patients with an absence of the internal carotid artery can be completely asymptomatic...
August 2016: Interventional Neuroradiology
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