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https://www.readbyqxmd.com/read/27909098/reversible-disruption-of-neuronal-mitochondria-by-ischemic-and-traumatic-injury-revealed-by-quantitative-two-photon-imaging-in-the-neocortex-of-anesthetized-mice
#1
Mikhail Kislin, Jeremy Sword, Ioulia V Fomitcheva, Deborah Croom, Evgeny Pryazhnikov, Eero Lihavainen, Dmytro Toptunov, Heikki Rauvala, Andre S Ribeiro, Leonard Khiroug, Sergei A Kirov
: Mitochondria play a variety of functional roles in cortical neurons, from metabolic support and neuroprotection to the release of cytokines that trigger apoptosis. In dendrites, mitochondrial structure is closely linked to their function, and fragmentation (fission) of the normally elongated mitochondria indicates loss of their function under such pathological conditions as stroke and brain trauma. Using in vivo two-photon microscopy in mouse brain, we quantified mitochondrial fragmentation in a full spectrum of cortical injuries ranging from severe to mild...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903772/diverse-activities-of-viral-cis-acting-rna-regulatory-elements-revealed-using-multi-color-long-term-single-cell-imaging
#2
Ginger M Pocock, Laraine L Zimdars, Ming Yuan, Kevin W Eliceiri, Paul Ahlquist, Nathan M Sherer
Cis-acting RNA structural elements govern crucial aspects of viral gene expression. How these structures and other post-transcriptional signals affect RNA trafficking and translation in the context of single cells is poorly understood. Herein we describe a multi-color, long-term (>24 h) imaging strategy for measuring integrated aspects of viral RNA regulatory control in individual cells. We apply this strategy to demonstrate differential mRNA trafficking behaviors governed by RNA elements derived from three retroviruses (HIV-1, murine leukemia virus, and Mason-Pfizer monkey virus), two hepadnaviruses (hepatitis B virus and woodchuck hepatitis virus) and an intron-retaining transcript encoded by the cellular NXF1 gene...
November 30, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27903053/a-comparison-of-temporal-and-location-based-sampling-strategies-for-global-positioning-system-triggered-electronic-diaries
#3
Tobias Törnros, Helen Dorn, Markus Reichert, Ulrich Ebner-Priemer, Hans-Joachim Salize, Heike Tost, Andreas Meyer-Lindenberg, Alexander Zipf
Self-reporting is a well-established approach within the medical and psychological sciences. In order to avoid recall bias, i.e. past events being remembered inaccurately, the reports can be filled out on a smartphone in real-time and in the natural environment. This is often referred to as ambulatory assessment and the reports are usually triggered at regular time intervals. With this sampling scheme, however, rare events (e.g. a visit to a park or recreation area) are likely to be missed. When addressing the correlation between mood and the environment, it may therefore be beneficial to include participant locations within the ambulatory assessment sampling scheme...
November 21, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27899311/seasonal-biotic-and-abiotic-factors-affecting-hunting-strategy-in-free-living-saharan-sand-vipers-cerastes-vipera
#4
Sefi J A Horesh, Jaim Sivan, Avi Rosenstrauch, Itay Tesler, A Allan Degen, Michael Kam
Sit-and-wait ambushing and active hunting are two strategies used by predators to capture prey. In snakes, hunting strategy is conserved phylogenetically; most species employ only one strategy. Active hunters encounter and capture more prey but invest more energy in hunting and have higher risks of being predated. This trade-off is important to small predators. The small Cerastes vipera employs both modes of hunting, which is unlike most viperids which use only sit-and wait ambushing. This species hibernates in October and emerges in April...
November 26, 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27896299/basement-membrane-ultrastructure-and-component-localization-data-from-uterine-tissues-during-early-mouse-pregnancy
#5
Celestial R Jones-Paris, Sayan Paria, Taloa Berg, Juan Saus, Gautam Bhave, Bibhash C Paria, Billy G Hudson
Basement membranes (BMs) are specialized extracellular scaffolds that provide architecture and modulate cell behaviors in tissues, such as fat, muscle, endothelium, endometrium, and decidua. Properties of BMs are maintained in homeostasis for most adult tissues. However, BM ultrastructure, composition, and localization are rapidly altered in select uterine tissues that are reprogrammed during pregnancy to enable early maternal-embryo interactions. Here, our data exhibit both static and dynamic BMs that were tracked in mouse uterine tissues during pre-, peri-, and postimplantation periods of pregnancy...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27867047/assessing-the-intra-species-genetic-variability-in-the-clonal-pathogen-campylobacter-fetus-crisprs-are-highly-polymorphic-dna-markers
#6
Lucía Calleros, Laura Betancor, Gregorio Iraola, Alejandra Méndez, Claudia Morsella, Fernando Paolicchi, Silvia Silveyra, Alejandra Velilla, Ruben Pérez
Campylobacter fetus is a Gram-negative, microaerophilic bacterium that infects animals and humans. The subspecies Campylobacter fetus subsp. fetus (Cff) affects a broad range of vertebrate hosts and induces abortion in cows and sheep. Campylobacter fetus subsp. venerealis (Cfv) is restricted to cattle and causes the endemic disease bovine genital campylobacteriosis, which triggers reproductive problems and is responsible for major economic losses. Campylobacter fetus subsp. testudinum (Cft) has been isolated mostly from apparently healthy reptiles belonging to different species but also from ill snakes and humans...
November 17, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27849548/an-end-to-end-model-of-plant-pheromone-channel-for-long-range-molecular-communications
#7
Bige Deniz Unluturk, Ian Akyildiz
A new track in molecular communication is using pheromones which can scale up the range of diffusion-based communication from meters to meters and enable new applications requiring long range. Pheromone communication is the emission of molecules in the air which trigger behavioral or physiological responses in receiving organisms. The objective of this paper is to introduce a new end-to-end model which incorporates pheromone behavior with communication theory for plants. The proposed model includes both the transmission and reception processes as well as the propagation channel...
November 11, 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/27825568/osteoarticular-manifestations-of-celiac-disease-and-non-celiac-gluten-hypersensitivity
#8
Stéphanie Dos Santos, Frédéric Lioté
Celiac disease is a chronic inflammatory autoimmune enteropathy based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. The global prevalence of 1% to 2% represents only the tip of the iceberg. The diagnosis is confirmed by positive specific antibody, anti-transglutaminase or anti-endomysium, specific lesions of the small intestine and a response to strict gluten-free diet. The diagnosis is difficult and often delayed because the clinical variability is very large, ranging from digestive clinical presentation "classic" to "atypical" symptoms, often extra-intestinal, that are sometimes attributed to a concomitant disease or a complication...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27824449/transient-weakening-of-earth-s-magnetic-shield-probed-by-a-cosmic-ray-burst
#9
P K Mohanty, K P Arunbabu, T Aziz, S R Dugad, S K Gupta, B Hariharan, P Jagadeesan, A Jain, S D Morris, B S Rao, Y Hayashi, S Kawakami, A Oshima, S Shibata, S Raha, P Subramanian, H Kojima
The GRAPES-3 tracking muon telescope in Ooty, India measures muon intensity at high cutoff rigidities (15-24 GV) along nine independent directions covering 2.3 sr. The arrival of a coronal mass ejection on 22 June 2015 18:40 UT had triggered a severe G4-class geomagnetic storm (storm). Starting 19:00 UT, the GRAPES-3 muon telescope recorded a 2 h high-energy (∼20  GeV) burst of galactic cosmic rays (GCRs) that was strongly correlated with a 40 nT surge in the interplanetary magnetic field (IMF)...
October 21, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27822310/anaphylactic-shock-during-cement-implantation-of-a-total-hip-arthroplasty-in-a-patient-with-underlying-mastocytosis-case-report-of-a-rare-intraoperative-complication
#10
Anita Ten Hagen, Pieter Doldersum, Tom van Raaij
BACKGROUND: Cemented total hip arthroplasty (THA) is a safe and common procedure. In rare cases life threatening bone cement implantation syndrome (BCIS) may occur, which is commonly caused by pulmonary embolism (PE). CASE PRESENTATION: We describe the rare case of a 70-year old patient who underwent an elective total hip replacement. Before surgery he was diagnosed with underlying systemic indolent mastocytosis, a rare pathological disorder that may result in anaphylaxis after massive systemic mast cell activation...
2016: Patient Safety in Surgery
https://www.readbyqxmd.com/read/27819476/interoception-in-pathological-health-anxiety
#11
Susann Krautwurst, Alexander L Gerlach, Michael Witthöft
According to cognitive-behavioral models, pathological health anxiety is triggered and maintained by the perception of mostly mild and benign bodily sensations that are misinterpreted as signs of illness. Arguably, abnormalities in interoception may account for this misguided preoccupation with somatic sensations. Using a multimethod approach, the current study investigated possible abnormalities in interoception in patients with pathological health anxiety (PHA; n = 51) and healthy participants (n = 56). Different types of interoception were assessed with a heartbeat-tracking task and a signal-detection task for nonspecific skin conductance fluctuations (NSCFs task)...
November 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27818655/prokaryotic-responses-to-ammonium-and-organic-carbon-reveal-alternative-co2-fixation-pathways-and-importance-of-alkaline-phosphatase-in-the-mesopelagic-north-atlantic
#12
Federico Baltar, Daniel Lundin, Joakim Palovaara, Itziar Lekunberri, Thomas Reinthaler, Gerhard J Herndl, Jarone Pinhassi
To decipher the response of mesopelagic prokaryotic communities to input of nutrients, we tracked changes in prokaryotic abundance, extracellular enzymatic activities, heterotrophic production, dark dissolved inorganic carbon (DIC) fixation, community composition (16S rRNA sequencing) and community gene expression (metatranscriptomics) in 3 microcosm experiments with water from the mesopelagic North Atlantic. Responses in 3 different treatments amended with thiosulfate, ammonium or organic matter (i.e., pyruvate plus acetate) were compared to unamended controls...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27812300/impact-observatory-tracking-the-evolution-of-clinical-trial-data-sharing-and-research-integrity
#13
REVIEW
Karmela Krleža-Jerić, Mirko Gabelica, Rita Banzi, Marina Krnić Martinić, Bibiana Pulido, Mersiha Mahmić-Kaknjo, Ludovic Reveiz, Josip Šimić, Ana Utrobičić, Irena Hrgović
INTRODUCTION: The opening of research data is emerging thanks to the increasing possibilities of digital technology. The opening of clinical trial (CT) data is a part of this process, expected to have positive scientific, ethical, health, and economic impacts thus contributing to research integrity. The January 2016 proposal by the International Council of Medical Journal Editors triggered ample discussion about CT data sharing and reconfirmed the need for an ongoing assessment of its dynamics...
October 15, 2016: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/27796279/functional-magnetic-porous-silica-for-t-1-t-2-dual-modal-magnetic-resonance-imaging-and-ph-responsive-drug-delivery-of-basic-drugs
#14
Ling Li, Run Zhang, Yi Guo, Cheng Zhang, Wei Zhao, Zhiping Xu, Andrew K Whittaker
A smart magnetic-targeting drug carrier γ-Fe2O3@p-silica comprising a γ-Fe2O3 core and porous shell has been prepared and characterized. The particles have a uniform size of about 60 nm, and a porous shell of thickness 3 nm. Abundant hydroxyl groups and a large surface area enabled the γ-Fe2O3@p-silica to be readily loaded with a large payload of the basic model drug rhodamine B (RB) (up to 73 mg g(-1)). Cytotoxicity assays of the γ-Fe2O3@p-silica particles indicated that the particles were biocompatible and suitable for carrying drugs...
October 31, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27792988/evaluation-of-maternal-early-obstetric-warning-system-meows-chart-as-a-predictor-of-obstetric-morbidity-a-prospective-observational-study
#15
Anju Singh, Kiran Guleria, Neelam B Vaid, Sandhya Jain
OBJECTIVES: Maternal Early Obstetric Warning System (MEOWS) chart adopted from CEMACH 2003-2005 report is based on the principle that abnormalities in physiological parameters precede critical illness. The 'track and trigger' of physiological parameters on this chart can aid in recognition of maternal morbidity at an early stage, ultimately halting the cascade of severe maternal morbidity and mortality. The objectives of our study were to evaluate MEOWS chart as a bedside screening tool for predicting obstetric morbidity and to correlate each physiological parameter individually with obstetric morbidity...
October 8, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27779585/exosomes-not-protein-or-lipids-in-mesenteric-lymph-activate-inflammation-unlocking-the-mystery-of-post-shock-multiple-organ-failure
#16
Mitsuaki Kojima, Joao Antonio Gimenes-Junior, Simone Langness, Koji Morishita, Ophelie Lavoie-Gagne, Brian Eliceiri, Todd W Costantini, Raul Coimbra
BACKGROUND: Previous studies have shown that mesenteric lymph (ML) has a crucial role in driving the systemic inflammatory response after trauma/hemorrhagic shock (T/HS). The specific mediators in the ML that contribute to its biological activity remain unclear despite decades of study. Exosomes are extracellular vesicles that are shed into body fluids such as serum and urine that can mediate intercellular communication. We hypothesized that exosomes are present in the ML after trauma/shock and are responsible for the biological activity of ML...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27741253/the-sense-of-agency-as-tracking-control
#17
Emilie A Caspar, Andrea Desantis, Zoltan Dienes, Axel Cleeremans, Patrick Haggard
Does sense of agency (SoA) arise merely from action-outcome associations, or does an additional real-time process track each step along the chain? Tracking control predicts that deviant intermediate steps between action and outcome should reduce SoA. In two experiments, participants learned mappings between two finger actions and two tones. In later test blocks, actions triggered a robot hand moving either the same or a different finger, and also triggered tones, which were congruent or incongruent with the mapping...
2016: PloS One
https://www.readbyqxmd.com/read/27732630/initiation-and-development-of-a-toxic-and-persistent-pseudo-nitzschia-bloom-off-the-oregon-coast-in-spring-summer-2015
#18
Xiuning Du, William Peterson, Jennifer Fisher, Matt Hunter, Jay Peterson
In spring/summer 2015, a toxic bloom by the diatom Pseudo-nitzschia (PN) occurred along the west coast of the United States which led to closures of the harvest of razor clams and Dungeness crabs. Twice monthly observations of temperature, salinity, nutrients, chlorophyll and phytoplankton species composition allowed us to track oceanographic conditions preceding and during the development of the bloom. PN cells were first detected during late winter 2015. A PN bloom was initiated following the onset of coastal upwelling in mid-April; subsequent peaks in May and June were sustained by episodic upwelling events and reached magnitudes of 105 cells/L and 106 cells/L, 40% and 90% of the total diatom abundance, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27714148/selective-killing-of-cells-triggered-by-their-mrna-signature-in-the-presence-of-smart-nanoparticles
#19
Amelie Heuer-Jungemann, Afaf H El-Sagheer, Peter M Lackie, Tom Brown, Antonios G Kanaras
The design of nanoparticles that can selectively perform multiple roles is of utmost importance for the development of the next generation of nanoparticulate drug delivery systems. So far most research studies are focused on the customization of nanoparticulate carriers to maximize their drug loading, enhance their optical signature for tracking in cells or provide photo-responsive effects for therapeutic purposes. However, a vital requirement of the new generation of drug carriers must be the ability to deliver their payload selectively only to cells of interest rather than the majority of various cells in the vicinity...
September 29, 2016: Nanoscale
https://www.readbyqxmd.com/read/27708645/sonar-a-high-throughput-pipeline-for-inferring-antibody-ontogenies-from-longitudinal-sequencing-of-b-cell-transcripts
#20
Chaim A Schramm, Zizhang Sheng, Zhenhai Zhang, John R Mascola, Peter D Kwong, Lawrence Shapiro
The rapid advance of massively parallel or next-generation sequencing technologies has made possible the characterization of B cell receptor repertoires in ever greater detail, and these developments have triggered a proliferation of software tools for processing and annotating these data. Of especial interest, however, is the capability to track the development of specific antibody lineages across time, which remains beyond the scope of most current programs. We have previously reported on the use of techniques such as inter- and intradonor analysis and CDR3 tracing to identify transcripts related to an antibody of interest...
2016: Frontiers in Immunology
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