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https://www.readbyqxmd.com/read/28935608/mechanical-coupling-of-microtubule-dependent-motor-teams-during-peroxisome-transport-in-drosophila-s2-cells
#1
María Cecilia De Rossi, Diana E Wetzler, Lorena Benseñor, María Emilia De Rossi, Mariela Sued, Daniela Rodríguez, Vladimir Gelfand, Luciana Bruno, Valeria Levi
BACKGROUND: Intracellular transport requires molecular motors that step along cytoskeletal filaments actively dragging cargoes through the crowded cytoplasm. Here, we explore the interplay of the opposed polarity motors kinesin-1 and cytoplasmic dynein during peroxisome transport along microtubules in Drosophila S2 cells. METHODS: We used single particle tracking with nanometer accuracy and millisecond time resolution to extract quantitative information on the bidirectional motion of organelles...
September 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28932820/reduced-arterial-elasticity-due-to-surgical-skeletonization-is-ameliorated-by-abluminal-peg-hydrogel
#2
Karyn G Robinson, Rebecca A Scott, Anne M Hesek, Edward J Woodford, Wafa Amir, Thomas A Planchon, Kristi L Kiick, Robert E Akins
Arteries for bypass grafting are harvested either with neighboring tissue attached or as skeletonized vessels that are free of surrounding tissue. There are significant benefits to skeletonization, but reports suggest that skeletonized vessels may develop structural defects and are at risk for atherosclerosis. We investigated the specific short-term effects of skeletonization on carotid artery biomechanics and microanatomy in a rabbit model. Six carotid arteries were surgically skeletonized. To support healing, three of these received polyethylene glycol hydrogel injected along their exterior surfaces...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/28904214/after-nerve-injury-lineage-tracing-shows-that-myelin-and-remak-schwann-cells-elongate-extensively-and-branch-to-form-repair-schwann-cells-which-shorten-radically-on-remyelination
#3
Jose A Gomez-Sanchez, Kjara S Pilch, Milou van der Lans, Shaline V Fazal, Cristina Benito, Laura J Wagstaff, Rhona Mirsky, Kristjan R Jessen
There is consensus that, distal to peripheral nerve injury, myelin and Remak cells reorganize to form cellular columns, Bungner's bands, which are indispensable for regeneration. However, knowledge of the structure of these regeneration tracks has not advanced for decades and the structure of the cells that form them, denervated or repair Schwann cells, remains obscure. Furthermore, the origin of these cells from myelin and Remak cells and their ability to give rise to myelin cells after regeneration has not been demonstrated directly, although these conversions are believed to be central to nerve repair...
September 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28903557/a-rheological-study-of-the-association-and-dynamics-of-muc5ac-gels
#4
Caroline E Wagner, Bradley S Turner, Michael Rubinstein, Gareth H McKinley, Katharina Ribbeck
The details of how the mucus hydrogel forms from its primary structural component, mucin polymers, remain incompletely resolved. To explore this, we use a combination of macrorheology and single particle tracking to investigate the bulk and microscopic mechanical properties of reconstituted MUC5AC mucin gels. We find that analyses of thermal fluctuations on the length scale of the micron-sized particles are not predictive of the linear viscoelastic response of the mucin gels, and that taken together, the results from both techniques help to provide complementary insight into the structure of the network...
September 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28893710/user-preferences-for-mobile-health-interventions-a-survey-among-intermittent-claudication-patients-and-their-physical-therapists
#5
Marijn Ml van den Houten, Steffie Spruijt, Hugo Jp Fokkenrood, Marc Rm Scheltinga, Joep Aw Teijink
OBJECTIVES: Smartphone apps provide novel ways of triggering lifestyle-change by coupling objective measurements of health behavior with tailored feedback. Little is known about end-user preferences regarding the content of mobile health (mHealth) interventions. The aim of this study was to assess smartphone use and preferences regarding app-content among intermittent claudication patients and their treating physical therapists. METHODS: A cross-sectional survey was sent via an internal email system to 1514 physical therapists specialized in treating patients with intermittent claudication...
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28893153/emotion-focused-perspective-on-generalized-anxiety-disorder-a-qualitative-analysis-of-clients-in-session-presentations
#6
Katie O'Brien, Nora O'Keeffe, Hannah Cullen, Aoife Durcan, Ladislav Timulak, James McElvaney
OBJECTIVE: The classification of generalized anxiety disorder (GAD) is influenced by the tradition of conceptualizing disorders in the context of their clinical presentation and subsequent professional thinking around them. Our qualitative, descriptive-interpretative study uses a theoretical framework drawn from emotion-focused therapy (EFT) as the basis of our interpretation of GAD clients' presentation of their difficulties. METHOD: The current research consists of an investigation into the GAD presentation based on a multiple case study observational qualitative design...
September 11, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28888695/characterization-of-seasonal-reproductive-and-stress-steroid-hormones-in-wild-radiated-tortoises-astrochelys-radiata
#7
Andrea F T Currylow, Tsilavo H Rafeliarisoa, Edward E Louis, Craig B Stanford, Soary T Randrianjafizanaka, Sarah M Chinn, Daniel E Crocker
The critically endangered Radiated Tortoise (Astrochelys radiata) is endemic to the southern coastlines of Madagascar. Once common, wild populations of this tortoise have undergone dramatic declines in recent years. Although there have been studies documenting reproductive activities, reproductive physiological parameters are unknown yet may be crucial in the recovery of the species. Over four research seasons in remote field locations native to A. radiata, we surveyed for, radio-tracked, and sampled wild, free ranging tortoises...
September 6, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28888199/chlorambucil-labelled-with-the-phenosafranin-scaffold-as-a-new-chemotherapeutic-for-imaging-and-cancer-treatment
#8
Beata Miksa, Malgorzata Sierant, Ewa Skorupska, Adam Michalski, Slawomir Kazmierski, Urszula Steinke, Artur Rozanski, Pawel Uznanski
Here we report the first of the phenosafranin-chlorambucil conjugate as a new type of a chemotherapeutic agent suitable for dual detection methods (spectrophotometric and fluorescence) in imaging systems and cancer treatment. The synthetic cationic dye (3,7-diamino-5-phenylphenazinium chloride) is used as a fluorescent light-triggered scaffold that acts as a carrier for an anti-cancer drug. The chlorambucil was attached covalently via amide bonds to the bifunctional fluorophore, which facilitates tracking with visible light...
September 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28885166/robust-fusion-of-color-and-depth-data-for-rgb-d-target-tracking-using-adaptive-range-invariant-depth-models-and-spatio-temporal-consistency-constraints
#9
Jingjing Xiao, Rustam Stolkin, Yuqing Gao, Ales Leonardis
This paper presents a novel robust method for single target tracking in RGB-D images, and also contributes a substantial new benchmark dataset for evaluating RGB-D trackers. While a target object's color distribution is reasonably motion-invariant, this is not true for the target's depth distribution, which continually varies as the target moves relative to the camera. It is therefore nontrivial to design target models which can fully exploit (potentially very rich) depth information for target tracking. For this reason, much of the previous RGB-D literature relies on color information for tracking, while exploiting depth information only for occlusion reasoning...
September 6, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28884569/endogenous-microrna-triggered-and-real-time-monitored-drug-release-via-cascaded-energy-transfer-payloads
#10
Fan Yang, Tingting Zhang, Shan-Shan Li, Pei Song, Kai Zhang, Qi-Yuan Guan, Bin Kang, Jing-Juan Xu, Hong-Yuan Chen
It is a great challenge to design a drug delivery system with controlled manner, especially, triggered by an exclusive endogenous disease marker and with an easily-tracked release process. Herein, we developed a drug delivery platform of carbon dots which connected to stem-loop molecular beacon loaded with doxorubicin and polyethylene glycol modified folic acid. Such platform enables to release drugs on demand under the stimuli of endogenous microRNA-21, and turn on the fluorescence of carbon dots and doxorubicin, which allows to monitor the drug release process...
September 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28880843/a-novel-dual-gating-approach-using-joint-inertial-sensors-implications-for-cardiac-pet-imaging
#11
Mojtaba Jafari Tadi, Jarmo Teuho, Eero Lennart Lehtonen, Antti Saraste, Mikko Pänkäälä, Tero Koivisto, Mika Teras
Positron emission tomography (PET) is a non-invasive imaging technique which may be considered as the state of art for the examination of cardiac inflammation due to atherosclerosis. A fundamental limitation of PET is that cardiac and respiratory motions reduce the quality of the achieved images. Current approaches for motion compensation involve gating the PET data based on the timing of quiescent periods of cardiac and respiratory cycles. In this study, we present a novel gating method called microelectromechanical (MEMS) dual gating which relies on joint non-electrical sensors, i...
September 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28878323/permanent-modifications-in-silica-produced-by-ion-induced-high-electronic-excitation-experiments-and-atomistic-simulations
#12
Antonio Rivera, José Olivares, Alejandro Prada, Miguel L Crespillo, María J Caturla, Eduardo M Bringa, José M Perlado, Ovidio Peña-Rodríguez
The irradiation of silica with ions of specific energy larger than ~0.1 MeV/u produces very high electronic excitations that induce permanent changes in the physical, chemical and structural properties and give rise to defects (colour centres), responsible for the loss of sample transparency at specific bands. This type of irradiation leads to the generation of nanometer-sized tracks around the ion trajectory. In situ optical reflection measurements during systematic irradiation of silica samples allowed us to monitor the irradiation-induced compaction, whereas ex situ optical absorption measurements provide information on colour centre generation...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28867959/structural-features-and-seismotectonic-implications-of-coseismic-surface-ruptures-produced-by-the-2016-mw-7-1-kumamoto-earthquake
#13
Aiming Lin
Field investigations and analyses of satellite images and aerial photographs reveal that the 2016 Mw 7.1 (Mj 7.3) Kumamoto earthquake produced a ∼40-km surface rupture zone striking NE-SW on central Kyushu Island, Japan. Coseismic surface ruptures were characterized by shear faults, extensional cracks, and mole tracks, which mostly occurred along the pre-existing NE-SW-striking Hinagu-Futagawa fault zone in the southwest and central segments, and newly identified faults in the northeast segment. This study shows that (i) the Hinagu-Futagawa fault zone triggered the 2016 Kumamoto earthquake and controlled the spatial distribution of coseismic surface ruptures; (ii) the southwest and central segments were dominated by right-lateral strike-slip movement with a maximum in-site measured displacement of up to 2...
2017: Journal of Seismology
https://www.readbyqxmd.com/read/28866143/construction-of-icg-encapsulated-w18o49-msn-as-a-fluorescence-carrier-for-real-time-tracked-photothermal-therapy
#14
Hui-Quan Wang, Peng-Fei Hu, Yu Zheng, Zhe Zhao, Bin Zheng, Jin Chang, Han-Jie Wang, Jin-Hai Wang
Photothermal therapy (PTT) has drawn tremendous attention because of its high therapeutic efficiency in targeting cells while minimizing the damage to normal tissues and organs. Tungsten oxide (W18O49, WO) plays a pivotal role in PTT development and its use in PTT systems has been extensively studied. However, it is difficult to control morphology of WO through conventional hydrothermal method. Which make its related researches have been limited up to now. In this study, we describe the construction and effects on tumor of a novel nanoplatform based on WO and indocyanine green (ICG) loaded in mesoporous silica nanoparticles (MSN) for dual-modal PTT and near-infrared imaging...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28864563/induced-parental-care-in-a-poison-frog-a-tadpole-cross-fostering-experiment
#15
Andrius Pašukonis, Kristina Barbara Beck, Marie-Therese Fischer, Steffen Weinlein, Susanne Stückler, Eva Ringler
Understanding the external stimuli and natural contexts that elicit complex behaviors, such as parental care, is key in linking behavioral mechanisms to their real-life function. Poison frogs provide obligate parental care by shuttling their tadpoles from terrestrial clutches to aquatic nurseries, but little is known about the proximate mechanisms that control these behaviors. In this study, we used Allobates femoralis, a poison frog with predominantly male parental care, to investigate whether tadpole transport can be induced in both sexes by transferring unrelated tadpoles to the backs of adults in the field...
September 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28864299/the-concerted-movement-of-the-switch-region-of-troponin-i-in-cardiac-muscle-thin-filaments-as-tracked-by-conventional-and-pulsed-deer-epr
#16
Phani R Potluri, Jean Chamoun, James A Cooke, Myriam Badr, Joanna A Guse, Roni Rayes, Nicole M Cordina, Dane McCamey, Piotr G Fajer, Louise J Brown
The absence of a crystal structure of the calcium free state of the cardiac isoform of the troponin complex has hindered our understanding of how the simple binding of Ca(2+) triggers conformational changes in troponin which are then propagated to enable muscle contraction. Here we have used continuous wave (CW) and Double Electron-Electron Resonance (DEER) pulsed EPR spectroscopy to measure distances between TnI and TnC to track the movement of the functionally important regulatory 'switch' region of the cardiac Tn...
August 29, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28858466/multilayered-magnetic-nanobeads-for-the-delivery-of-peptides-molecules-triggered-by-intracellular-proteases
#17
Alessandra Quarta, Marina Rodio, Marco Cassani, Giuseppe Gigli, Teresa Pellegrino, Loretta L Del Mercato
In this work the versatility of layer-by-layer technology was combined with the magnetic response of iron oxide nanobeads to prepare magnetic mesostructures with a degradable multilayer shell into which a dye quenched ovalbumin conjugate (DQ-OVA) was loaded. The system was specifically designed to prove the protease sensitivity of the hybrid mesoscale system and the easy detection of the ovalbumin released. The uptake of the nanostructures in the breast cancer cells was followed by the effective release of DQ-OVA upon activation via the intracellular proteases degradation of the polymer shells...
August 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28851914/simulated-forward-and-backward-self-motion-based-on-realistic-parameters-causes-motion-induced-blindness
#18
Victoria Thomas, Matthew Davidson, Parisa Zakavi, Naotsugu Tsuchiya, Jeroen van Boxtel
Motion Induced Blindness (MIB) is a well-established visual phenomenon whereby highly salient targets disappear when viewed against a moving background mask. No research has yet explored whether contracting and expanding optic flow can also trigger target disappearance. We explored MIB using mask speeds corresponding to driving at 35, 50, 65 and 80 km/h in simulated forward (expansion) and backward (contraction) motion as well as 2-D radial movement, random, and static mask motion types. Participants (n = 18) viewed MIB targets against masks with different movement types, speed, and target locations...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851886/inference-on-paleoclimate-change-using-microbial-habitat-preference-in-arctic-holocene-sediments
#19
Dukki Han, Seung-Il Nam, Ji-Hoon Kim, Ruediger Stein, Frank Niessen, Young Jin Joe, Yu-Hyeon Park, Hor-Gil Hur
The present study combines data of microbial assemblages with high-resolution paleoceanographic records from Core GC1 recovered in the Chukchi Sea. For the first time, we have demonstrated that microbial habitat preferences are closely linked to Holocene paleoclimate records, and found geological, geochemical, and microbiological evidence for the inference of the sulphate-methane transition zone (SMTZ) in the Chukchi Sea. In Core GC1, the layer of maximum crenarchaeol concentration was localized surrounding the SMTZ...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837266/covalent-dimerization-of-interleukin-like-epithelial-to-mesenchymal-transition-emt-inducer-ilei-facilitates-emt-invasion-and-late-aspects-of-metastasis
#20
Maria Kral, Christoph Klimek, Betül Kutay, Gerald Timelthaler, Thomas Lendl, Benjamin Neuditschko, Christopher Gerner, Maria Sibilia, Agnes Csiszar
The interleukin-like epithelial-to-mesenchymal transition (EMT) inducer (ILEI)/FAM3C is a member of the highly homologous FAM3 family and is essential for EMT and metastasis formation. It is upregulated in several cancers, and its altered subcellular localization strongly correlates with poor survival. However, the mechanism of ILEI action, including the structural requirements for ILEI activity, remains elusive. Here, we show that ILEI formed both monomers and covalent dimers in cancer cell lines and in tumors...
August 24, 2017: FEBS Journal
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