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https://www.readbyqxmd.com/read/28430109/acquisition-of-electrocardiogram-signals-during-magnetic-resonance-imaging
#1
Julien Oster, Gari Clifford
The recording of the electrocardiogram (ECG) during Magnetic Resonance Imaging (MRI) acquisition is of great interest and importance. Firstly, MRI acquisition is a relatively slow process, which therefore complicates the imaging of moving organs. Cardiac MRI requires the development of strategies for acquiring high quality images, which is mainly achieved by synchronising the image acquisition with a specific time during the cardiac cycle. The ECG is used to monitor the heart's activity, and the detection of the largest and steepest peak in the cardiac cycle (the QRS complex) triggers the acquisition of slices of the k-space...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28424898/patient-experiences-of-swallowing-exercises-after-head-and-neck-cancer-a-qualitative-study-examining-barriers-and-facilitators-using-behaviour-change-theory
#2
Roganie Govender, Caroline E Wood, Stuart A Taylor, Christina H Smith, Helen Barratt, Benjamin Gardner
Poor patient adherence to swallowing exercises is commonly reported in the dysphagia literature on patients treated for head and neck cancer. Establishing the effectiveness of exercise interventions for this population may be undermined by patient non-adherence. The purpose of this study was to explore the barriers and facilitators to exercise adherence from a patient perspective, and to determine the best strategies to reduce the barriers and enhance the facilitators. In-depth interviews were conducted on thirteen patients...
April 19, 2017: Dysphagia
https://www.readbyqxmd.com/read/28424583/a-rodent-model-of-dynamic-facial-reanimation-using-functional-electrical-stimulation
#3
Mark A Attiah, Julius de Vries, Andrew G Richardson, Timothy H Lucas
Facial paralysis can be a devastating condition, causing disfiguring facial droop, slurred speech, eye dryness, scarring and blindness. This study investigated the utility of closed-loop functional electric stimulation (FES) for reanimating paralyzed facial muscles in a quantitative rodent model. The right buccal and marginal mandibular branches of the rat facial nerve were transected for selective, unilateral paralysis of whisker muscles. Microwire electrodes were implanted bilaterally into the facial musculature for FES and electromyographic (EMG) recording...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28423529/pif-promotes-brain-re-myelination-locally-while-regulating-systemic-inflammation-clinically-relevant-multiple-sclerosis-m-smegmatis-model
#4
Giuseppe Migliara, Martin Mueller, Alessia Piermattei, Chaya Brodie, Michael J Paidas, Eytan R Barnea, Francesco Ria
Neurologic disease diagnosis and treatment is challenging. Multiple Sclerosis (MS) is a demyelinating autoimmune disease with few clinical forms and uncertain etiology. Current studies suggest that it is likely caused by infection(s) triggering a systemic immune response resulting in antigen/non-antigen-related autoimmune response in central nervous system (CNS). New therapeutic approaches are needed. Secreted by viable embryos, PreImplantation Factor (PIF) possesses a local and systemic immunity regulatory role...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422691/event-sampled-direct-adaptive-nn-output-and-state-feedback-control-of-uncertain-strict-feedback-system
#5
Nathan Szanto, Vignesh Narayanan, Sarangapani Jagannathan
In this paper, a novel event-triggered implementation of a tracking controller for an uncertain strict-feedback system is presented. Neural networks (NNs) are utilized in the backstepping approach to design a control input by approximating unknown dynamics of the strict-feedback nonlinear system with event-sampled inputs. The system state vector is assumed to be unknown and an NN observer is used to estimate the state vector. By using the estimated state vector and backstepping design approach, an event-sampled controller is introduced...
April 12, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28412035/novel-consequences-of-bird-pollination-for-plant-mating
#6
REVIEW
Siegfried L Krauss, Ryan D Phillips, Jeffrey D Karron, Steven D Johnson, David G Roberts, Stephen D Hopper
Pollinator behaviour has profound effects on plant mating. Pollinators are predicted to minimise energetic costs during foraging bouts by moving between nearby flowers. However, a review of plant mating system studies reveals a mismatch between behavioural predictions and pollen-mediated gene dispersal in bird-pollinated plants. Paternal diversity of these plants is twice that of plants pollinated solely by insects. Comparison with the behaviour of other pollinator groups suggests that birds promote pollen dispersal through a combination of high mobility, limited grooming, and intra- and interspecies aggression...
April 12, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28409150/mitotic-catastrophe-in-bc3h1-cells-following-yessotoxin-exposure
#7
Mónica Suárez Korsnes, Reinert Korsnes
The marine toxin yessotoxin (YTX) can cause various cytotoxic effects depending on cell type and cell line. It is well known to trigger distinct mechanisms for programmed cell death which may overlap or cross-talk. The present contribution provides the first evidence that YTX can cause genotoxicity and induce mitotic catastrophe which can lead to different types of cell death. This work also demonstrates potential information gain from non-intrusive computer-based tracking of many individual cells during long time...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28406596/improving-early-identification-of-hiv-infected-neonates-with-birth-pcr-testing-in-a-large-urban-hospital-in-johannesburg-south-africa-successes-and-challenges
#8
Karl-Günter Technau, Louise Kuhn, Ashraf Coovadia, Sergio Carmona, Gayle Sherman
INTRODUCTION: Timely diagnosis is necessary to avert early death in HIV-infected neonates. Birth PCR testing may improve early identification and facilitate access to care. We implemented a birth HIV diagnosis programme in Johannesburg, South Africa and present successes and challenges of the first two and a half years of operation. METHODS: Between June 2014 and December 2016, we sought to identify all HIV-exposed births and offer newborn HIV PCR testing before discharge after delivery...
April 10, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28402886/three-dimensional-super-resolution-in-eukaryotic-cells-using-the-double-helix-point-spread-function
#9
Alexander R Carr, Aleks Ponjavic, Srinjan Basu, James McColl, Ana Mafalda Santos, Simon Davis, Ernest D Laue, David Klenerman, Steven F Lee
Single-molecule localization microscopy, typically based on total internal reflection illumination, has taken our understanding of protein organization and dynamics in cells beyond the diffraction limit. However, biological systems exist in a complicated three-dimensional environment, which has required the development of new techniques, including the double-helix point spread function (DHPSF), to accurately visualize biological processes. The application of the DHPSF approach has so far been limited to the study of relatively small prokaryotic cells...
April 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28396677/gametocidal-factor-transferred-from-aegilops-geniculata-roth-can-be-adapted-for-large-scale-chromosome-manipulations-in-cereals
#10
Michał T Kwiatek, Halina Wiśniewska, Aurelia Ślusarkiewicz-Jarzina, Joanna Majka, Maciej Majka, Jolanta Belter, Hanna Pudelska
Segregation distorters are curious, evolutionarily selfish genetic elements, which distort Mendelian segregation in their favor at the expense of others. Those agents include gametocidal factors (Gc), which ensure their preferential transmission by triggering damages in cells lacking them via chromosome break induction. Hence, we hypothesized that the gametocidal system can be adapted for chromosome manipulations between Triticum and Secale chromosomes in hexaploid triticale (×Triticosecale Wittmack). In this work we studied the little-known gametocidal action of a Gc factor located on Aegilops geniculata Roth chromosome 4M(g)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28391218/analysis-and-design-of-synchronization-for-heterogeneous-network
#11
Yuanqing Wu, Renquan Lu, Peng Shi, Hongye Su, Zheng-Guang Wu
In this paper, we investigate the synchronization for heterogeneous network subject to event-triggering communication. The designed controller for each node includes reference generator (RG) and regulator. The predicted value of relative information between intermittent communication can significantly reduce the transmitted information. Based on the event triggering strategy and time-dependent threshold, all RGs can exponentially track the target trajectory. Then by the action of regulator, each node synchronizes with its RG...
April 3, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28387042/circumpolar-dynamics-of-a-marine-top-predator-track-ocean-warming-rates
#12
S Descamps, T Anker-Nilssen, R T Barrett, D B Irons, F Merkel, G J Robertson, N G Yoccoz, M L Mallory, W A Montevecchi, D Boertmann, Y Artukhin, S Christensen-Dalsgaard, K E Erikstad, H G Gilchrist, A L Labansen, S-H Lorentsen, A Mosbech, B Olsen, A Petersen, J-F Rail, H M Renner, H Strøm, G H Systad, S I Wilhelm, L Zelenskaya
Global warming is a non-linear process and temperature may increase in a stepwise manner. Periods of abrupt warming can trigger persistent changes in the state of ecosystems, also called regime shifts. The responses of organisms to abrupt warming and associated regime shifts can be unlike responses to periods of slow or moderate change. Understanding of non-linearity in the biological responses to climate warming is needed to assess the consequences of ongoing climate change. Here we demonstrate that the population dynamics of a long-lived, wide-ranging marine predator are associated with changes in the rate of ocean warming...
April 7, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28386043/nongated-cardiac-computed-tomographic-angiograms-for-detection-of-embolic-sources-in-acute-ischemic-stroke
#13
Leonard L L Yeo, Staffan Holmin, Tommy Andersson, Erik Lundström, Anil Gopinathan, Er Luen Lim, Benjamin S H Leong, Win Sen Kuan, Eric Ting, Benjamin Y Q Tan, Sterling Ellis Eide, Edgar L K Tay
BACKGROUND AND PURPOSE: We assessed the feasibility of obtaining diagnostic quality images of the heart and thoracic aorta by extending the z axis coverage of a non-ECG-gated computed tomographic angiogram performed in the primary evaluation of acute stroke without increasing the contrast dose. METHODS: Twenty consecutive patients with acute ischemic stroke within the 4.5 hours of symptom onset were prospectively recruited. We increased the longitudinal coverage to the domes of the diaphragm to include the heart...
April 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28378721/synthesis-and-structures-of-photoactive-manganese-carbonyl-complexes-derived-from-2-pyridin-2-yl-1-3-benzothiazole-and-2-quinolin-2-yl-1-3-benzothiazole
#14
Jenny Stenger-Smith, Indranil Chakraborty, Samantha Carrington, Pradip Mascharak
PhotoCORMs (photo-active CO-releasing molecules) have emerged as a class of CO donors where the CO release process can be triggered upon illumination with light of appropriate wavelength. We have recently reported an Mn-based photoCORM, namely [MnBr(pbt)(CO)3] [pbt is 2-(pyridin-2-yl)-1,3-benzothiazole], where the CO release event can be tracked within cellular milieu by virtue of the emergence of strong blue fluorescence. In pursuit of developing more such trackable photoCORMs, we report herein the syntheses and structural characterization of two Mn(I)-carbonyl complexes, namely fac-tricarbonylchlorido[2-(pyridin-2-yl)-1,3-benzothiazole-κ(2)N,N']manganese(I), [MnCl(C12H8N2S)(CO)3], (1), and fac-tricarbonylchlorido[2-(quinolin-2-yl)-1,3-benzothiazole-κ(2)N,N']manganese(I), [MnCl(C16H10N2S)(CO)3], (2)...
April 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28370540/use-of-13-c-and-phosphate-18-o-labeled-substrate-for-studying-phosphorus-and-carbon-cycling-in-soils-a-proof-of-concept
#15
Avner Gross, Alon Angert
RATIONALE: Stable isotopes tracers are commonly used to track the transformations of organic carbon (C) and nitrogen (N) in soils but have not been used to follow coupled cycles of phosphorus (P) and C because P has only one stable isotope. METHODS: A novel dually labeled substrate composed of a (13) C-labeled glucose backbone attached to a phosphate group with known δ(18) OP value was used to follow the fate of C and P derived from the same compound. The tracer was amended to soils from two natural Oak forests and the δ(13) C values of respired CO2 and the δ(18) OP values of soil bioavailable P were measured...
March 30, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28364395/severe-and-asymptomatic-aortic-stenosis-management-challenge-knowing-that-we-do-not-really-know
#16
REVIEW
Lionel Tastet, Louis Simard, Marie-Annick Clavel
The clinical management of asymptomatic patients with severe aortic valve stenosis (AS) may be challenging. Indeed, there is substantial controversy over the optimal timing of intervention for these patients, as some advocate early intervention while others urge for a conservative management until symptom onset. In the meantime of randomized clinical trials aiming to compare both strategies of management, an integrative approach including several imaging modalities as well as biomarkers of the myocardial damage may help to improve the risk stratification of patients with asymptomatic severe AS and individualize strategy of treatment...
May 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28347947/thermosensitive-hydrogel-loaded-with-chitosan-carbon-nanotubes-for-near-infrared-light-triggered-drug-delivery
#17
Xia Dong, Chang Wei, Jie Liang, Tianjun Liu, Deling Kong, Feng Lv
Controlled drug release with on demand is an important challenge for drug delivery. Near-infrared (NIR) light triggered drug delivery reflected the development of a significant strategy to control drug release based on photothermal effects. Herein, a sustained and controlled drug delivery system was developed based on a PCL-PEG-PCL thermosensitive hydrogel combined with chitosan-multiwalled carbon nanotubes for a near infrared light triggered drug delivery. Carbon nanotubes that incorporate hydrogel can enhance the sustained effect of drug delivery by a dual-stage release and allow drug delivery by controlling light irradiation...
March 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28345936/co-registered-molecular-logic-gate-with-a-co-releasing-molecule-triggered-by-light-and-peroxide
#18
Upendar Reddy G, Jörg Axthelm, Patrick Hoffmann, Nandaraj Taye, Steve Gläser, Helmar Görls, Samantha L Hopkins, Winfried Plass, Ute Neugebauer, Sylvestre Bonnet, Alexander Schiller
Co-registered molecular logic gates combine two different inputs and outputs, such as light and matter. We introduce a biocompatible CO-releasing molecule (CORM, A) as Mn(I) tricarbonyl complex with the ligand 5-(dimethylamino)-N, N-bis(pyridin-2-ylmethyl) naphthalene-1-sulfonamide (L). CO release is chaperoned by turn-on fluorescence and can be triggered by light (405 nm) as well as with hydrogen peroxide in aqueous phosphate buffer. Complex A behaves as a logic "OR" gate via co-registering the inputs of irradiation (light) and peroxide (matter) into the concomitant outputs fluorescence (light) and CO (matter)...
April 3, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28344867/cd4-and-cd8-t-cells-are-both-needed-to-induce-paraneoplastic-neurological-disease-in-a-mouse-model
#19
Christina Gebauer, Béatrice Pignolet, Lidia Yshii, Emilie Mauré, Jan Bauer, Roland Liblau
Paraneoplastic neurological disorders (PNDs) are rare human autoimmune diseases that mostly affect the central nervous system (CNS). They are triggered by an efficient immune response against a neural self-antigen that is ectopically expressed in neoplastic tumors. Due to this shared antigenic expression, the immune system reacts not only to tumor cells but also to neural cells resulting in neurological damage. Growing data point to a major role of cell-mediated immunity in PNDs associated to autoantibodies against intracellular proteins...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28332215/effects-of-increased-left-ventricular-wall-thickness-on-the-myocardium-in-severe-aortic-stenosis-with-normal-left-ventricular-ejection-fraction-two-and-three-dimensional-multilayer-speckle-tracking-echocardiography
#20
Eun Jeong Cho, Sung-Ji Park, Eun Kyoung Kim, Ga Yeon Lee, Sung-A Chang, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park
BACKGROUND: The aim of this study was to determine the capability of real time three-dimensional echocardiography (RT3DE) and two-dimensional (2D) multilayer speckle tracking echocardiography (MSTE) for evaluation of early myocardial dysfunction triggered by increased left ventricular (LV) wall thickness in severe aortic stenosis (AS) with normal LV ejection fraction (EF≥55%). METHODS: Conventional, RT3D STE and 2D MSTE were performed in 45 patients (mean 68.9±9...
March 23, 2017: Echocardiography
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