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https://www.readbyqxmd.com/read/28319203/relationship-between-low-tube-voltage-70-kv-and-the-iodine-delivery-rate-idr-in-ct-angiography-an-experimental-in-vivo-study
#1
Michael M Lell, Ulrike Fleischmann, Hubertus Pietsch, Johannes G Korporaal, Ulrike Haberland, Andreas H Mahnken, Thomas G Flohr, Michael Uder, Gregor Jost
OBJECTIVE: Very short acquisition times and the use of low-kV protocols in CTA demand modifications in the contrast media (CM) injection regimen. The aim of this study was to optimize the use of CM delivery parameters in thoraco-abdominal CTA in a porcine model. MATERIALS AND METHODS: Six pigs (55-68 kg) were examined with a dynamic CTA protocol (454 mm scan length, 2.5 s temporal resolution, 70 s total acquisition time). Four CM injection protocols were applied in a randomized order...
2017: PloS One
https://www.readbyqxmd.com/read/28301074/high-throughput-inclusion-body-sizing-nano-particle-tracking-analysis
#2
Wieland N Reichelt, Andreas Kaineder, Markus Brillmann, Lukas Neutsch, Alexander Taschauer, Hans Lohninger, Christoph Herwig
The expression of pharmaceutical relevant proteins in E. coli frequently triggers inclusion body (IB) formation caused by protein aggregation. In literature, substantial effort has been invested into the quantification of IB size. But up to this date particle based methods to analyze physical IB properties of representative numbers of IBs lack sensitivity and/or lack orthogonal verification. Using high pressure freezing and automated freeze substitution for transmission electron microscopy (TEM) the cytosolic inclusion body structure was preserved within the cells...
March 16, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28297995/phase-analysis-method-for-burst-onset-prediction
#3
Flavio Stellino, Alberto Mazzoni, Marco Storace
The response of bursting neurons to fluctuating inputs is usually hard to predict, due to their strong nonlinearity. For the same reason, decoding the injected stimulus from the activity of a bursting neuron is generally difficult. In this paper we propose a method describing (for neuron models) a mechanism of phase coding relating the burst onsets with the phase profile of the input current. This relation suggests that burst onset may provide a way for postsynaptic neurons to track the input phase. Moreover, we define a method of phase decoding to solve the inverse problem and estimate the likelihood of burst onset given the input state...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28294319/grpr-antagonist-protects-from-drug-induced-liver-injury-by-impairing-neutrophil-chemotaxis-and-motility
#4
Rafael S Czepielewski, Natália Jaeger, Pedro E Marques, Maísa M Antunes, Maurício M Rigo, Débora M Alvarenga, Rafaela V Pereira, Rodrigo D da Silva, Tiago G Lopes, Vinícius D da Silva, Bárbara N Porto, Gustavo B Menezes, Cristina Bonorino
Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF), where hepatocyte necrotic products trigger liver inflammation, release of CXCR2 ligands (IL-8) and other neutrophil chemotactic molecules. Liver infiltration by neutrophils is a major cause of the life threatening tissue damage that ensues. A GRPR (gastrin-releasing peptide receptor) antagonist impairs IL-8-induced neutrophil chemotaxis in vitro. We investigated its potential to reduce acetaminophen-induced ALF, neutrophil migration and mechanisms underlying this phenomenon...
March 10, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28292743/-the-score-matters-wide-variations-in-predictive-performance-of-18-paediatric-track-and-trigger-systems
#5
Susan M Chapman, Jo Wray, Kate Oulton, Christina Pagel, Samiran Ray, Mark J Peters
OBJECTIVE: To compare the predictive performance of 18 paediatric early warning systems (PEWS) in predicting critical deterioration. DESIGN: Retrospective case-controlled study. PEWS values were calculated from existing clinical data, and the area under the receiver operator characteristic curve (AUROC) compared. SETTING: UK tertiary referral children's hospital. PATIENTS: Patients without a 'do not attempt resuscitation' order admitted between 1 January 2011 and 31 December 2012...
March 14, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28292677/multiple-lines-of-evidence-to-identify-sewage-as-the-cause-of-water-quality-impairment-in-an-urbanized-tropical-watershed
#6
Marek Kirs, Veljo Kisand, Mayee Wong, Roberto A Caffaro-Filho, Philip Moravcik, Valerie J Harwood, Bunnie Yoneyama, Roger S Fujioka
Indicator bacteria, which are conventionally used to evaluate recreational water quality, can originate from various non-human enteric and extra-enteric sources, hence they may not be indicative of human health risk nor do they provide information on the sources of contamination. In this study we utilized traditional (enterococci and Escherichia coli) and alternative (Clostridium perfringens) indicator bacteria, F(+)-specific coliphage, molecular markers for microorganisms associated with human sewage (human-associated Bacteroides and polyomaviruses), and microbial community analysis tools (16S rRNA gene fragment amplicon sequencing), to identify and evaluate human sewage-related impact in the Manoa watershed in Honolulu, Hawaii...
March 10, 2017: Water Research
https://www.readbyqxmd.com/read/28290186/phosphorus-and-other-aspects-of-ckd-mbd-in-the-conservative-management-of-chronic-kidney-disease
#7
Anuja Shah
As the prevalence of chronic kidney disease (CKD) increases and the population ages, there is an imperative to offer cost effective and patient specific therapeutic options for the management of advanced CKD. In cases where there is a desire to avoid or delay renal replacement therapy, conservative options need to be defined and strategies for delaying the need for renal replacement therapy should be offered. CKD-mineral bone disorders (MBD) refers to the constellation of disturbances in abnormal bone and soft tissue calcification along with abnormalities, in phosphorus, calcium, parathyroid hormone, vitamin D, and FGF-23...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28270286/initial-experience-of-the-application-of-third-generation-dual-source-ct-scanner-in-high-pitch-angiography-of-aorta
#8
Jixiang Liang, Lingyan Kong, Zhengyu Jin, Yun Wang, Huadan Xue, Yining Wang, Daming Zhang, Jin Chen
Objective To evaluate the value of third-generation dual-source CT scanner in application of high-pitch aorta CT angiography(CTA). Methods Totally 59 patients clinically indicated for whole aorta angiography were divided into 2 groups using a simple random method:in group 1 there were 28 patients who underwent the examination on a third-generation dual-source CT device,with a collimation of 2×192×0.6 mm and a rotation time of 0.25 s;in group 2 there were 31 patients who underwent the examination on a second generation dual-source CT device,with a collimation of 2×128×0...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28270285/initial-experience-of-the-application-of-automated-tube-potential-selection-technique-in-high-pitch-dual-source-ct-angiography-of-whole-aorta-using-third-generation-dual-source-ct-scanner
#9
Lingyan Kong, Jixiang Liang, Huadan Xue, Yining Wang, Yun Wang, Zhengyu Jin, Daming Zhang, Jin Chen
Objective To evaluate the application of automated tube potential selection technique in high-pitch dual-source CT aortic angiography on a third-generation dual-source CT scanner. Methods Whole aorta angiography were indiated in 59 patients,who were divided into 2 groups using a simple random method:in group 1 there were 31 patients who underwent the examination with automated tube potential selection using a vascular setting with a preferred image quality of 288 mA/100 kV;in group 2 there were 28 patients who underwent the examination with a tube voltage of 100 kV and automated tube current modulation using a reference tube current of 288 mA...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28268973/a-modular-closed-loop-platform-for-intracranial-stimulation-in-people-with-neurological-disorders
#10
Anish A Sarma, Britni Crocker, Sydney S Cash, Wilson Truccolo
Neuromodulation systems based on electrical stimulation can be used to investigate, probe, and potentially treat a range of neurological disorders. The effects of ongoing neural state and dynamics on stimulation response, and of stimulation parameters on neural state, have broad implications for the development of closed-loop neuro-modulation approaches. We describe the development of a modular, low-latency platform for pre-clinical, closed-loop neuromodulation studies with human participants. We illustrate the uses of the platform in a stimulation case study with a person with epilepsy undergoing neuro-monitoring prior to resective surgery...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268575/determining-the-difference-in-eyegaze-measurements-in-individuals-with-age-related-macular-degeneration
#11
Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim
Age-related Macular Degeneration (AMD) is one of the leading causes of blindness in the elderly. Visual loss associated with AMD often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods of detecting AMD are typically manual, require holding fixation and an external response trigger. In this paper, we propose the use of eyegaze tracking to detect for the presence of AMD, using a simple set of test patterns. Experimental results show that the derived eyegaze measurements can help to identify individuals with AMD from healthy individuals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266334/processing-grammatical-gender-in-dutch-evidence-from-eye-movements
#12
Susanne Brouwer, Simone Sprenger, Sharon Unsworth
Previous research has demonstrated that grammatical gender in Dutch is typically acquired late. Most of this work used production data only, and consequently children's knowledge of Dutch gender may have been underestimated. In this study, therefore, we examined whether 49 4- to 7-year-old Dutch-speaking children (and 19 adult controls) were able to use gender marking in the article preceding the object label during online sentence processing to (a) anticipate the upcoming object label or to (b) facilitate the processing of that label as it is presented...
March 3, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28261670/tracking-the-subtle-mutations-driving-host-sensing-by-the-plant-pathogen-streptomyces-scabies
#13
Samuel Jourdan, Isolde M Francis, Benoit Deflandre, Rosemary Loria, Sébastien Rigali
The acquisition of genetic material conferring the arsenal necessary for host virulence is a prerequisite on the path to becoming a plant pathogen. More subtle mutations are also required for the perception of cues signifying the presence of the target host and optimal conditions for colonization. The decision to activate the pathogenic lifestyle is not "taken lightly" and involves efficient systems monitoring environmental conditions. But how can a pathogen trigger the expression of virulence genes in a timely manner if the main signal inducing its pathogenic behavior originates from cellulose, the most abundant polysaccharide on earth? This situation is encountered by Streptomyces scabies, which is responsible for common scab disease on tuber and root crops...
March 2017: MSphere
https://www.readbyqxmd.com/read/28255726/in-vivo-imaging-of-t-cell-immunological-synapses-and-kinapses-in-lymph-nodes
#14
Hélène D Moreau, Philippe Bousso
T cells can become activated in lymph nodes following a diverse set of interactions with antigen-presenting cells. These cellular contacts range from short and dynamic to stable and long-lasting interactions, termed kinapses and synapses, respectively. Here, we describe a methodology to generate naïve T cells expressing a fluorescent probe of interest through the generation of bone marrow chimeras and to image T cell dynamics using intravital two-photon microscopy. In these settings, the formation of kinapses and synapses can be triggered by the administration of low and high affinity peptides, respectively...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28255706/two-dimensional-analysis-of-cross-junctional-molecular-interaction-by-force-probes
#15
Lining Ju, Yunfeng Chen, Muaz Nik Rushdi, Wei Chen, Cheng Zhu
Upon engagement with a specific ligand, a cell surface receptor transduces intracellular signals to activate various cellular functions. This chapter describes a set of biomechanical methods for analyzing the characteristics of cross-junctional receptor-ligand interactions at the surface of living cells. These methods combine the characterization of kinetics of receptor-ligand binding with real-time imaging of intracellular calcium fluxes, which allow researchers to assess how the signal initiated from single receptor-ligand engagement is transduced across the cell membrane...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28249387/-dna-origami-traffic-lights-with-a-split-aptamer-sensor-for-a-bicolor-fluorescence-readout
#16
Heidi-Kristin Walter, Jens Bauer, Jeannine Steinmeyer, Akinori Kuzuya, Christof M Niemeyer, Hans-Achim Wagenknecht
A split aptamer for adenosine triphosphate (ATP) was embedded as a recognition unit into two levers of a nanomechanical DNA origami construct by extension and modification of selected staple strands. An additional optical module in the stem of the split aptamer comprised two different cyanine-styryl dyes that underwent an energy transfer from green (donor) to red (acceptor) emission if two ATP molecules were bound as target molecule to the recognition module and thereby brought the dyes in close proximity. As a result, the ATP as a target triggered the DNA origami shape transition and yielded a fluorescence color change from green to red as readout...
March 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28240636/computed-tomography-pulmonary-angiogram-dynamic-parameter-correlation-with-pulmonary-pressure-and-pulmonary-hypertension-etiologies
#17
Yoel Siegel, Drew Bleicher, Michael Kurt Gordon, Debra Fertel
OBJECTIVE: Pulmonary hypertension (PH) is caused by etiologies that differ in pathophysiology. Patients with undiagnosed PH may have a computed tomography pulmonary angiography (CTPA) scan during workup. Static measurements on computed tomography correlate with PH; however, dynamic parameters have received less attention. We studied the correlation between CTPA dynamic parameters and PH and assessed whether these parameters differ among PH etiologies. We also propose a method for PH screening...
February 24, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28239568/expression-of-hepatitis-b-virus-surface-antigens-induces-defective-gonad-phenotypes-in-caenorhabditis-elegans
#18
Yi-Yin Chen, Li-Wei Lee, Wei-Ning Hong, Szecheng J Lo
AIM: To test whether a simple animal, Caenorhabditis elegans (C. elegans), can be used as an alternative model to study the interaction between hepatitis B virus antigens (HBsAg) and host factors. METHODS: Three plasmids that were able to express the large, middle and small forms of HBsAgs (LHBsAg, MHBsAg, and SHBsAg, respectively) driven by a ubiquitous promoter (fib-1) and three that were able to express SHBsAg driven by different tissue-specific promoters were constructed and microinjected into worms...
February 12, 2017: World Journal of Virology
https://www.readbyqxmd.com/read/28227183/a-modular-closed-loop-platform-for-intracranial-stimulation-in-people-with-neurological-disorders
#19
Anish A Sarma, Britni Crocker, Sydney S Cash, Wilson Truccolo, Anish A Sarma, Britni Crocker, Sydney S Cash, Wilson Truccolo, Sydney S Cash, Wilson Truccolo, Anish A Sarma, Britni Crocker
Neuromodulation systems based on electrical stimulation can be used to investigate, probe, and potentially treat a range of neurological disorders. The effects of ongoing neural state and dynamics on stimulation response, and of stimulation parameters on neural state, have broad implications for the development of closed-loop neuro-modulation approaches. We describe the development of a modular, low-latency platform for pre-clinical, closed-loop neuromodulation studies with human participants. We illustrate the uses of the platform in a stimulation case study with a person with epilepsy undergoing neuro-monitoring prior to resective surgery...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226753/determining-the-difference-in-eyegaze-measurements-in-individuals-with-age-related-macular-degeneration
#20
Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Augustinus Laude, Huiying Liu, Tock Han Lim, Fengshou Yin, Yanwu Xu, Damon Wong, Ai Ping Yow
Age-related Macular Degeneration (AMD) is one of the leading causes of blindness in the elderly. Visual loss associated with AMD often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods of detecting AMD are typically manual, require holding fixation and an external response trigger. In this paper, we propose the use of eyegaze tracking to detect for the presence of AMD, using a simple set of test patterns. Experimental results show that the derived eyegaze measurements can help to identify individuals with AMD from healthy individuals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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