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https://www.readbyqxmd.com/read/28227183/a-modular-closed-loop-platform-for-intracranial-stimulation-in-people-with-neurological-disorders
#1
Anish A Sarma, Britni Crocker, Sydney S Cash, Wilson Truccolo, Anish A Sarma, Britni Crocker, Sydney S Cash, Wilson Truccolo, Sydney S Cash, Wilson Truccolo, Anish A Sarma, Britni Crocker
Neuromodulation systems based on electrical stimulation can be used to investigate, probe, and potentially treat a range of neurological disorders. The effects of ongoing neural state and dynamics on stimulation response, and of stimulation parameters on neural state, have broad implications for the development of closed-loop neuro-modulation approaches. We describe the development of a modular, low-latency platform for pre-clinical, closed-loop neuromodulation studies with human participants. We illustrate the uses of the platform in a stimulation case study with a person with epilepsy undergoing neuro-monitoring prior to resective surgery...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226753/determining-the-difference-in-eyegaze-measurements-in-individuals-with-age-related-macular-degeneration
#2
Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Augustinus Laude, Huiying Liu, Tock Han Lim, Fengshou Yin, Yanwu Xu, Damon Wong, Ai Ping Yow
Age-related Macular Degeneration (AMD) is one of the leading causes of blindness in the elderly. Visual loss associated with AMD often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods of detecting AMD are typically manual, require holding fixation and an external response trigger. In this paper, we propose the use of eyegaze tracking to detect for the presence of AMD, using a simple set of test patterns. Experimental results show that the derived eyegaze measurements can help to identify individuals with AMD from healthy individuals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220987/brain-tissue-reaction-to-deep-brain-stimulation-a-longitudinal-study-of-dbs-in-the-goettingen-minipig
#3
Dariusz Orlowski, Alexandre Michalis, Andreas N Glud, Anders R Korshøj, Lise M Fitting, Trine W Mikkelsen, André Mercanzini, Alain Jordan, Alain Dransart, Jens C H Sørensen
OBJECTIVES: The use of Deep Brain Stimulation (DBS) in treatment of various brain disorders is constantly growing; however, the number of studies of the reaction of the brain tissue toward implanted leads is still limited. Therefore, the aim of our study was to analyze the impact of DBS leads on brain tissue in a large animal model using minipigs. METHODS: Twelve female animals, one control and eleven with bilaterally implanted DBS electrodes were used in our experiment...
February 21, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28214452/calorie-counting-and-fitness-tracking-technology-associations-with-eating-disorder-symptomatology
#4
Courtney C Simpson, Suzanne E Mazzeo
The use of online calorie tracking applications and activity monitors is increasing exponentially. Anecdotal reports document the potential for these trackers to trigger, maintain, or exacerbate eating disorder symptomatology. Yet, research has not examined the relation between use of these devices and eating disorder-related attitudes and behaviors. This study explored associations between the use of calorie counting and fitness tracking devices and eating disorder symptomatology. Participants (N=493) were college students who reported their use of tracking technology and completed measures of eating disorder symptomatology...
February 9, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28214103/tracking-the-evolution-and-differences-between-guest-induced-phases-of-ga-mil-53-via-ultra-wideline-69-71-ga-solid-state-nmr-spectroscopy
#5
Yue Zhang, Bryan E G Lucier, Victor V Terskikh, Renlong Zheng, Yining Huang
Ga-MIL-53 is a metal-organic framework (MOF) that exhibits a "breathing effect," in which the pore size and overall MOF topology can be influenced by temperature, pressure, and host-guest interactions. The phase control afforded by this flexible framework renders Ga-MIL-53 a promising material for guest storage and sensing applications. In this work, the structure and behavior of four Ga-MIL-53 phases (as, ht, enp and lt), along with CO2 adsorbed within Ga-MIL-53 at various loading levels, has been investigated using (69/71)Ga solid-state NMR (SSNMR) experiments at 21...
January 31, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28214036/impact-of-filling-gas-on-subharmonic-emissions-of-phospholipid-ultrasound-contrast-agents
#6
Emma Kanbar, Damien Fouan, Charles A Sennoga, Alexander A Doinikov, Ayache Bouakaz
Subharmonic signals backscattered from gas-filled lipid-shelled microbubbles have generated significant research interest because they can improve the detection and sensitivity of contrast-enhanced ultrasound imaging. However, the emission of subharmonic signals is strongly characterized by a temporal dependence, the origins of which have not been sufficiently elucidated. The features that influence subharmonic emissions need to be identified not only to better develop next-generation microbubble contrast agents, but also to develop more efficient subharmonic imaging (SHI) modes and therapeutic strategies...
February 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28211008/injected-amyloid-beta-in-the-olfactory-bulb-transfers-to-other-brain-regions-via-neural-connections-in-mice
#7
Baixuan He, Minying Zheng, Qiang Liu, Zhe Shi, Simei Long, Xilin Lu, Zhong Pei, Ti-Fei Yuan, Huanxing Su, Xiaoli Yao
Alzheimer's disease (AD) is characterized by progressive neuronal degeneration and pathological accumulation of amyloid plaques in the brain. It has been proposed that the prion-like spreading of amyloid beta (Aβ) protein could contribute to the progression of the disease. Olfactory bulb (OB) is one of the earliest brain regions affected in AD and olfaction is easily impaired prior to cognitive symptoms. However, it remains unclear whether Aβ accumulation in the OB would spread along olfactory projections to other connected brain regions and trigger further neurodegeneration...
February 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28192672/smart-nanostructures-for-cargo-delivery-uncaging-and-activating-by-light
#8
Mahdi Karimi, Parham Sahandi Zangabad, Soodeh Baghaee-Ravari, Mahdi Ghazizadeh, Hamed Mirshekari, Michael R Hamblin
Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, etc. Among drug delivery systems (DDSs), smart nanocarriers that can respond to specific stimuli in their local environment represent a growing field. Nanoplatforms that can be activated by an external application of light, can be used for a wide variety of photo-activated therapies, (especially light-triggered DDSs) relying on photo-isomerization, photo-crosslinking/uncrosslinking, photo-reduction, etc...
February 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28187461/lysosomal-accumulation-of-anticancer-drugs-triggers-lysosomal-exocytosis
#9
Benny Zhitomirsky, Yehuda G Assaraf
We have recently shown that hydrophobic weak base anticancer drugs are highly sequestered in acidic lysosomes, inducing TFEB-mediated lysosomal biogenesis and markedly increased lysosome numbers per cell. This enhanced lysosomal sequestration of chemotherapeutics, away from their intracellular targets, provoked cancer multidrug resistance. However, little is known regarding the fate of lysosome-sequestered drugs. While we suggested that sequestered drugs might be expelled from cancer cells via lysosomal exocytosis, no actual drug-induced lysosomal exocytosis was demonstrated...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28167752/cross-cultural-regularities-in-the-cognitive-architecture-of-pride
#10
Daniel Sznycer, Laith Al-Shawaf, Yoella Bereby-Meyer, Oliver Scott Curry, Delphine De Smet, Elsa Ermer, Sangin Kim, Sunhwa Kim, Norman P Li, Maria Florencia Lopez Seal, Jennifer McClung, Jiaqing O, Yohsuke Ohtsubo, Tadeg Quillien, Max Schaub, Aaron Sell, Florian van Leeuwen, Leda Cosmides, John Tooby
Pride occurs in every known culture, appears early in development, is reliably triggered by achievements and formidability, and causes a characteristic display that is recognized everywhere. Here, we evaluate the theory that pride evolved to guide decisions relevant to pursuing actions that enhance valuation and respect for a person in the minds of others. By hypothesis, pride is a neurocomputational program tailored by selection to orchestrate cognition and behavior in the service of: (i) motivating the cost-effective pursuit of courses of action that would increase others' valuations and respect of the individual, (ii) motivating the advertisement of acts or characteristics whose recognition by others would lead them to enhance their evaluations of the individual, and (iii) mobilizing the individual to take advantage of the resulting enhanced social landscape...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28166228/rapid-turnover-of-dnaa-at-replication-origin-regions-contributes-to-initiation-control-of-dna-replication
#11
Katrin Schenk, Ana B Hervás, Thomas C Rösch, Marc Eisemann, Bernhard A Schmitt, Stephan Dahlke, Luise Kleine-Borgmann, Seán M Murray, Peter L Graumann
DnaA is a conserved key regulator of replication initiation in bacteria, and is homologous to ORC proteins in archaea and in eukaryotic cells. The ATPase binds to several high affinity binding sites at the origin region and upon an unknown molecular trigger, spreads to several adjacent sites, inducing the formation of a helical super structure leading to initiation of replication. Using FRAP analysis of a functional YFP-DnaA allele in Bacillus subtilis, we show that DnaA is bound to oriC with a half-time of 2...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28156482/implementing-an-emergency-department-emr-trigger-tool-for-palliative-medicine-consultation-and-its-effect-on-length-of-stay-and-health-care-costs-a-retrospective-study
#12
Felix Rivera, Wendy Edwards
: 167 Background: Several studies have shown that palliative medicine consultation can improve multiple patient-centered outcomes, especially when provided early. Our goal is to show that our electronic health record (EHR) trigger tool is a cost-effective way for hospitals to identify patients who may benefit from early consultation, improving outcomes such as hospital length of stay and facilitating appropriate disposition for patients with metastatic cancer. METHODS: Retrospective chart review of 721 patients at an urban community hospital who were identified by a trigger system integrated into the Emergency Department (ED) EHR...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152864/use-of-an-automated-notification-tool-to-drive-real-time-patient-symptom-intervention
#13
Brandon Bosch, Diane Denny, Maurie Markman
: 160 Background: Cancer Treatment Centers of America, Inc. (CTCA) is a national network of hospitals that specialize in the treatment of patients fighting complex or advanced-stage cancer. The Symptom Inventory Tool (SIT) is an assessment tool that captures the patients' perceived symptom burden for real-time clinical intervention, from baseline and every 21 days thereafter. The SIT is comprised of questions utilizing the M.D. Anderson Symptom Inventory tool, a validated assessment instrument with questions added and a free text box by CTCA...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28149888/scoring-systems-for-the-characterization-of-sepsis-and-associated-outcomes
#14
COMMENT
Natalie McLymont, Guy W Glover
Sepsis is responsible for the utilisation of a significant proportion of healthcare resources and has high mortality rates. Early diagnosis and prompt interventions are associated with better outcomes but is impeded by a lack of diagnostic tools and the heterogeneous and enigmatic nature of sepsis. The recently updated definitions of sepsis have moved away from the centrality of inflammation and the systemic inflammatory response syndrome (SIRS) criteria which have been shown to be non-specific. Sepsis is now defined as a "life-threatening organ dysfunction caused by a dysregulated host response to infection"...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28139696/rewiring-carotenoid-biosynthesis-in-plants-using-a-viral-vector
#15
Eszter Majer, Briardo Llorente, Manuel Rodríguez-Concepción, José-Antonio Daròs
Plants can be engineered to sustainably produce compounds of nutritional, industrial or pharmaceutical relevance. This is, however, a challenging task as extensive regulation of biosynthetic pathways often hampers major metabolic changes. Here we describe the use of a viral vector derived from Tobacco etch virus to express a whole heterologous metabolic pathway that produces the health-promoting carotenoid lycopene in tobacco tissues. The pathway consisted in three enzymes from the soil bacteria Pantoea ananatis...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28134966/coordinated-control-of-three-dimensional-components-of-smooth-pursuit-to-rotating-and-translating-textures
#16
Janick Edinger, Dinesh K Pai, Miriam Spering
Purpose: The neural control of pursuit eye movements to visual textures that simultaneously translate and rotate has largely been neglected. Here we propose that pursuit of such targets-texture pursuit-is a fully three-dimensional task that utilizes all three degrees of freedom of the eye, including torsion. Methods: Head-fixed healthy human adults (n = 8) tracked a translating and rotating random dot pattern, shown on a computer monitor, with their eyes. Horizontal, vertical, and torsional eye positions were recorded with a head-mounted eye tracker...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28134657/burning-pain-axonal-dysfunction-in-erythromelalgia
#17
Michelle A Farrar, Ming-Jen Lee, James Howells, P Ian Andrews, Cindy S-Y Lin
Erythromelalgia (EM) is a rare neurovascular disorder characterized by intermittent severe burning pain, erythema and warmth in the extremities upon heat stimuli. To investigate the underlying pathophysiology, peripheral axonal excitability studies were performed and changes with heating and therapy explored. Multiple excitability indices (stimulus-response curve, strength-duration time constant (SDTC), threshold electrotonus and recovery cycle) were investigated in 23(9 EMSCN9A+, 14 EMSCN9A-) genetically characterized EM patients stimulating median motor and sensory axons at the wrist...
January 24, 2017: Pain
https://www.readbyqxmd.com/read/28129180/surface-reconstruction-via-fusing-sparse-sequence-of-depth-images
#18
Long Yang, Qingan Yan, Yanping Fu, Chunxia Xiao
Handheld scanning using commodity depth cameras provides a flexible and low-cost manner to get 3D models. The existing methods scan a target by densely fusing all the captured depth images, yet most frames are redundant. The jittering frames inevitably embedded in handheld scanning process will cause feature blurring on the reconstructed model and even trigger the scan failure (i.e., camera tracking losing). To address these problems, in this paper, we propose a novel sparse-sequence fusion (SSF) algorithm for handheld scanning using commodity depth cameras...
January 25, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28113950/an-end-to-end-model-of-plant-pheromone-channel-for-long-range-molecular-communications
#19
Bige Deniz Unluturk, Ian Akyildiz
A new track in molecular communication is using pheromones which can scale up the range of diffusion-based communication from meters to meters and enable new applications requiring long range. Pheromone communication is the emission of molecules in the air which trigger behavioral or physiological responses in receiving organisms. The objective of this paper is to introduce a new end-to-end model which incorporates pheromone behavior with communication theory for plants. The proposed model includes both the transmission and reception processes as well as the propagation channel...
November 11, 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28113387/cooperative-control-of-mobile-sensor-networks-for-environmental-monitoring-an-event-triggered-finite-time-control-scheme
#20
Qiang Lu, Qing-Long Han, Botao Zhang, Dongliang Liu, Shirong Liu
This paper deals with the problem of environmental monitoring by developing an event-triggered finite-time control scheme for mobile sensor networks. The proposed control scheme can be executed by each sensor node independently and consists of two parts: one part is a finite-time consensus algorithm while the other part is an event-triggered rule. The consensus algorithm is employed to enable the positions and velocities of sensor nodes to quickly track the position and velocity of a virtual leader in finite time...
August 30, 2016: IEEE Transactions on Cybernetics
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