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https://www.readbyqxmd.com/read/28093803/novel-ecg-synchronized-pulsatile-ecls-system-with-various-heart-rates-and-cardiac-arrhythmias-an-in-vitro-study
#1
Shigang Wang, Shannon B Spencer, Allen R Kunselman, Akif Ündar
The objective of this study is to evaluate electrocardiography (ECG)-synchronized pulsatile flow under varying heart rates and different atrial and ventricular arrhythmias in a simulated extracorporeal life support (ECLS) system. The ECLS circuit consisted of an i-cor diagonal pump and console, an iLA membrane ventilator, and an 18 Fr arterial cannula. The circuit was primed with lactated Ringer's solution and packed red blood cells (hematocrit 35%). An ECG simulator was used to trigger pulsatile flow and to generate selected cardiac rhythms...
January 2017: Artificial Organs
https://www.readbyqxmd.com/read/28092433/design-and-analysis-of-localized-dna-hybridization-chain-reactions
#2
Hieu Bui, Vincent Miao, Sudhanshu Garg, Reem Mokhtar, Tianqi Song, John Reif
Theoretical models of localized DNA hybridization reactions on nanoscale substrates indicate potential benefits over conventional DNA hybridization reactions. Recently, a few approaches have been proposed to speed-up DNA hybridization reactions; however, experimental confirmation and quantification of the acceleration factor have been lacking. Here, a system to investigate localized DNA hybridization reactions on a nanoscale substrate is presented. The system consists of six metastable DNA hairpins that are tethered to a long DNA track...
January 16, 2017: Small
https://www.readbyqxmd.com/read/28090258/echocardiographic-and-histologic-correlations-in-patients-with-severe-aortic-stenosis-influence-of-overweight-and-obesity
#3
Nydia Ávila-Vanzzini, Juan Francisco Fritche-Salazar, Nelva Marina Vázquez-Castro, Pedro Rivera-Lara, Oscar Pérez-Méndez, Humberto Martínez-Herrera, Mario Gómez-Sánchez, Alberto Aranda-Frausto, Héctor Herrera-Bello, María Luna-Luna, José Antonio Arias Godínez
BACKGROUND: Severe aortic stenosis (AS), leads to pathological left ventricular remodeling that may worsen with concomitant overweight and obesity (OW/O). METHODS: We aimed to prospectively analyze the impact of OW/O on ventricular remodeling in severe AS, by evaluating the percentage of intraendomyocardial fibrosis (PIEF) and the percentage of infiltrating intraendocardial lipid vacuoles (PIELV) and its relationship to global longitudinal strain (GLS) in patients with OW/O...
December 2016: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28079956/an-exonuclease-iii-powered-on-particle-stochastic-dna-walker
#4
Xiangmeng Qu, Dan Zhu, Guangbao Yao, Shao Su, Jie Chao, Huajie Liu, Xiaolei Zuo, Lihua Wang, Jiye Shi, Lianhui Wang, Wei Huang, Hao Pei, Chunhai Fan
DNA-based machines have attracted rapidly growing interest owing to their potential in drug delivery, biocomputing, and diagnostic applications. Herein, we report a type of exonuclease III (Exo III)-powered stochastic DNA walker that can autonomously move on a spherical nucleic acid (SNA)-based 3D track. The motion is propelled by unidirectional Exo III digestion of hybridized DNA tracks in a burnt-bridge mechanism. The operation of this Exo III-propelled DNA walker was monitored in real time and at the single-particle resolution using total internal reflection fluorescence microscopy (TIRF)...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28077726/climbing-fibers-control-purkinje-cell-representations-of-behavior
#5
Martha L Streng, Laurentiu S Popa, Timothy J Ebner
: A crucial issue in understanding cerebellar function is the interaction between simple spike (SS) and complex spike (CS) discharge, the two fundamentally different activity modalities of Purkinje cells. Although several hypotheses have provided insights into the interaction, none fully explain or are completely consistent with the spectrum of experimental observations. Here, we show that during a pseudo-random manual tracking task in the monkey (Macaca mulatta), climbing fiber discharge dynamically controls the information present in the SS firing, triggering robust and rapid changes in the SS encoding of motor signals in 67% of Purkinje cells...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28077713/reversible-disruption-of-neuronal-mitochondria-by-ischemic-and-traumatic-injury-revealed-by-quantitative-two-photon-imaging-in-the-neocortex-of-anesthetized-mice
#6
Mikhail Kislin, Jeremy Sword, Ioulia V Fomitcheva, Deborah Croom, Evgeny Pryazhnikov, Eero Lihavainen, Dmytro Toptunov, Heikki Rauvala, Andre S Ribeiro, Leonard Khiroug, Sergei A Kirov
: Mitochondria play a variety of functional roles in cortical neurons, from metabolic support and neuroprotection to the release of cytokines that trigger apoptosis. In dendrites, mitochondrial structure is closely linked to their function, and fragmentation (fission) of the normally elongated mitochondria indicates loss of their function under pathological conditions, such as stroke and brain trauma. Using in vivo two-photon microscopy in mouse brain, we quantified mitochondrial fragmentation in a full spectrum of cortical injuries, ranging from severe to mild...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28064496/alkaline-phosphatase-triggered-simultaneous-hydrogelation-and-chemiluminescence
#7
Zijuan Hai, Jindan Li, Jingjing Wu, Jiacheng Xu, Gaolin Liang
Chemiluminescence (CL) has a higher signal-to-noise ratio than fluorescence, but the use of CL to track an enzyme-instructed self-assembly (EISA) process has not been reported. In this work, by coincubation of the hydrogelator precursor Fmoc-Phe-Phe-Tyr(H2PO3)-OH (1P) and the CL agent AMPPD (2) with alkaline phosphatase (ALP), we employed CL to directly characterize and image the simultaneous EISA process of 1P. Hydrogelation processes of 1P with and without 2 and the CL properties of 2 with and without 1P under ALP catalysis were systematically studied...
January 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28048412/su-c-202-03-a-tool-for-automatic-calculation-of-delivered-dose-variation-for-off-line-adaptive-therapy-using-cone-beam-ct
#8
B Zhang, S Lee, S Chen, J Zhou, K Prado, W D'Souza, B Yi
PURPOSE: Monitoring the delivered dose is an important task for the adaptive radiotherapy (ART) and for determining time to re-plan. A software tool which enables automatic delivered dose calculation using cone-beam CT (CBCT) has been developed and tested. METHODS: The tool consists of four components: a CBCT Colleting Module (CCM), a Plan Registration Moduel (PRM), a Dose Calculation Module (DCM), and an Evaluation and Action Module (EAM). The CCM is triggered periodically (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046869/su-g-bra-12-development-of-an-intra-fractional-motion-tracking-and-dose-reconstruction-system-for-adaptive-stereotactic-body-radiation-therapy-in-high-risk-prostate-cancer
#9
N Hassan Rezaeian, Y Chi, Z Tian, S Jiang, R Hannan, X Jia
PURPOSE: A clinical trial on stereotactic body radiation therapy (SBRT) for high-risk prostate cancer is undergoing at our institution. In addition to escalating dose to the prostate, we have increased dose to intra-prostatic lesions. Intra-fractional prostate motion deteriorates well planned radiation dose, especially for the small intra-prostatic lesions. To solve this problem, we have developed a motion tracking and 4D dose-reconstruction system to facilitate adaptive re-planning. METHODS: Patients in the clinical trial were treated with VMAT using four arcs and 10 FFF beam...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046391/su-d-brc-07-system-design-for-a-3d-volumetric-scintillation-detector-using-scmos-cameras
#10
C Darne, D Robertson, F Alsanea, S Beddar
PURPOSE: The purpose of this project is to build a volumetric scintillation detector for quantitative imaging of 3D dose distributions of proton beams accurately in near real-time. METHODS: The liquid scintillator (LS) detector consists of a transparent acrylic tank (20×20×20 cm(3) ) filled with a liquid scintillator that when irradiated with protons generates scintillation light. To track rapid spatial and dose variations in spot scanning proton beams we used three scientific-complementary metal-oxide semiconductor (sCMOS) imagers (2560×2160 pixels)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046218/su-g-jep1-02-a-new-intra-fractional-prostate-motion-tracking-method-in-volumetric-modulated-arc-therapy-vmat-via-2d-3d-registration
#11
Y Chi, N Hassan Rezaeian, R Hannan, X Jia
PURPOSE: Intra-fractional prostate motion leads uncertainty on delivered dose in radiotherapy and may cause significant dose deviation from the planned dose distribution. This is especially a concern in scenarios with a high dose per fraction and hence a long delivery time, e.g. stereotactic body radiotherapy. Knowledge about intra-fractional prostate motion is valuable to address this problem, e.g. by reconstructing delivered dose and performing adaptation. This study proposes a new approach to determine intra-fractional prostate motion in VMAT via 2D/3D maker registration...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041785/a-semi-quantitative-translational-pharmacology-analysis-to-understand-the-relationship-between-in-vitro-ent1-inhibition-and-the-clinical-incidence-of-dyspnoea-and-bronchospasm
#12
Lyn Rosenbrier Ribeiro, R Ian Storer
Adenosine contributes to the pathophysiology of respiratory disease, and adenosine challenge leads to bronchospasm and dyspnoea in patients. The equilibrative nucleoside transporter 1 (ENT1) terminates the action of adenosine by removal from the extracellular environment. Therefore, it is proposed that inhibition of ENT1 in respiratory disease patients leads to increased adenosine concentrations, triggering bronchospasm and dyspnoea. This study aims to assess the translation of in vitro ENT1 inhibition to the clinical incidence of bronchospasm and dyspnoea in respiratory disease, cardiovascular disease and healthy volunteer populations...
December 29, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28038344/application-based-on-the-canny-edge-detection-algorithm-for-recording-contractions-of-isolated-cardiac-myocytes
#13
Jair Trapé Goulart, Rosana Almada Bassani, José Wilson Magalhães Bassani
BACKGROUND AND OBJECTIVE: The isolated cardiomyocyte preparation is amenable to several experimental approaches not suitable to the myocardial tissue, which has allowed the gain of important information on the pathophysiology of the cardiac muscle. Thus, the development of techniques for functional studies in this preparation is important. The goal of the present study was to develop a computer program to extract contraction traces generated by cyclic cell shortening from cardiomyocyte video image files...
December 21, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28031396/operant-conditioning-of-neural-activity-in-freely-behaving-monkeys-with-intracranial-reinforcement
#14
Ryan W Eaton, Tyler Libey, Eberhard E Fetz
Operant conditioning of neural activity has typically been performed under controlled behavioral conditions using food reinforcement. This has limited the duration and behavioral context for neural conditioning. To reward cell activity in unconstrained primates, we sought sites in nucleus accumbens (NAc) whose stimulation reinforced operant responding. In three monkeys NAc stimulation sustained performance of a manual target-tracking task, with response rates that increased monotonically with increasing NAc stimulation...
December 28, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28027752/optimal-timing-of-image-acquisition-for-arterial-first-pass-ct-myocardial-perfusion-imaging
#15
G J Pelgrim, E R Nieuwenhuis, T M Duguay, R J van der Geest, A Varga-Szemes, C H Slump, S R Fuller, M Oudkerk, U J Schoepf, R Vliegenthart
PURPOSE: To determine the optimal timing of arterial first pass computed tomography (CT) myocardial perfusion imaging (CTMPI) based on dynamic CTMPI acquisitions. METHODS AND MATERIALS: Twenty-five patients (59±8.4years, 14 male)underwent adenosine-stress dynamic CTMPI on second-generation dual-source CT in shuttle mode (30s at 100kV and 300mAs). Stress perfusion magnetic resonance imaging (MRI) was used as reference standard for differentiation of non-ischemic and ischemic segments...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28007431/quantifying-in-vivo-murine-antigen-specific-t-cell-responses-without-requirement-for-prior-knowledge-of-antigen-identity
#16
Nour Kibbi, Enping Hong, Harib Ezaldein, Douglas Hanlon, Tarek Fahmy, Richard Edelson
Extracorporeal Photochemotherapy (ECP) is a widely applied anti-cancer immunotherapy for patients with cutaneous T cell lymphoma (CTCL). By using apoptotic malignant cells as a source of patient-specific tumor antigen, it enables clinically relevant and curative anti-CTCL immunity, with potential efficacy in other tumors. Currentmethods to track patient-specific responses are tedious, and new methods are needed to assess putative global immunity. We developed a clinically practical method to assess antigen-specific T cell activation that does not rely on knowledge of the particular antigen, thereby eliminating the requirement for patient-specific reagents...
November 30, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28007382/analysis-of-bloom-conditions-in-fall-2013-in-the-strait-of-hormuz-using-satellite-observations-and-model-simulations
#17
Jun Zhao, Marouane Temimi, Muchamad Al Azhar, Hosni Ghedira
In this study an algal bloom event in fall 2013 in the Strait of Hormuz was thoroughly investigated using satellite remote sensing and hydrodynamic modeling. The motivation of this study is to deduce ambient conditions prior to and during the bloom outbreak and understand its trigger. Bloom tracking was achieved by sequential MODIS imagery and numerical simulations. Satellite observations showed that the bloom was initiated in late October 2013 and dissipated in early June 2014. Trajectories of bloom patches were simulated using a Lagrangian transport model...
December 19, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28000671/local-synthesis-of-dynein-cofactors-matches-retrograde-transport-to-acutely-changing-demands
#18
Joseph M Villarin, Ethan P McCurdy, José C Martínez, Ulrich Hengst
Cytoplasmic dynein mediates retrograde transport in axons, but it is unknown how its transport characteristics are regulated to meet acutely changing demands. We find that stimulus-induced retrograde transport of different cargos requires the local synthesis of different dynein cofactors. Nerve growth factor (NGF)-induced transport of large vesicles requires local synthesis of Lis1, while smaller signalling endosomes require both Lis1 and p150(Glued). Lis1 synthesis is also triggered by NGF withdrawal and required for the transport of a death signal...
December 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27992236/creating-new-opportunities-to-educate-families-on-the-impact-of-frailty-and-cognitive-impairment-in-a-trauma-intensive-care-unit-results-of-a-quality-improvement-project
#19
Mohana B Karlekar, Cathy A Maxwell, Mary S Dietrich, Richard S Miller
BACKGROUND: Older adults comprise a rapidly growing proportion of admissions to acute care hospitals and trauma centers. Older adults admitted to a trauma intensive care unit (TICU) often have a more complicated inpatient and posthospital course. This is the most pronounced in frail elders with cognitive dysfunction. We aimed at integrating validated screening instruments for physical frailty and cognitive impairment into the standard nursing assessment of all older trauma patients admitted to our TICU and stepdown unit...
February 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27956874/globalization-and-pollution-tele-connecting-local-primary-pm2-5-emissions-to-global-consumption
#20
Jing Meng, Junfeng Liu, Yuan Xu, Dabo Guan, Zhu Liu, Ye Huang, Shu Tao
Globalization pushes production and consumption to geographically diverse locations and generates a variety of sizeable opportunities and challenges. The distribution and associated effects of short-lived primary fine particulate matter (PM2.5), a representative of local pollution, are significantly affected by the consumption through global supply chain. Tele-connection is used here to represent the link between production and consumption activity at large distances. In this study, we develop a global consumption-based primary PM2...
November 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
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