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https://www.readbyqxmd.com/read/29234387/antioxidant-activity-of-a-geopropolis-from-northeast-brazil-chemical-characterization-and-likely-botanical-origin
#1
Joselena M Ferreira, Caroline C Fernandes-Silva, Antonio Salatino, Dejair Message, Giuseppina Negri
Geopropolis is a product containing wax, plant resin, and soil particles. It is elaborated by stingless bees of tribe Meliponini. Methanol extracts of sample of geopropolis produced by Scaptotrigona postica ("mandaguari") in the state of Rio Grande do Norte (RN, northeast Brazil) were analyzed for the determination of standard parameters (total phenols, total flavonoids, and radical scavenging activity) and chemical characterization by HPLC-DAD-MS/MS analysis. The sample analyzed has high contents of total phenols and flavonoids, as well as high antioxidant activity...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29229073/disinfection-of-dentinal-tubules-with-2-chlorhexidine-gel-calcium-hydroxide-and-herbal-intracanal-medicaments-against-enterococcus-faecalis-an-in-vitro-study
#2
Agrima Vasudeva, Dakshita Joy Sinha, Shashi Prabha Tyagi, Narendra Nath Singh, Paridhi Garg, Deepti Upadhyay
AIM: This in vitro study was conducted to evaluate the disinfection of dentinal tubules using 2% Chlorhexidine gel, Honey, Aloe vera gel, Curcuma longa, Propolis gel and Calcium hydroxide against Enterococcus faecalis. MATERIALS AND METHOD: Two hundred and ten human mandibular first premolars were infected with Enterococcus faecalis for 21 days. Samples were divided into 7 groups. Group I- Saline (negative control), Group II- 2% Chlorhexidine gel(CHX), Group III- honey, Group IV- Aloe vera gel, Group V- 20% Curcuma longa gel, Group VI- Propolis gel and Group VII -Calcium hydroxide (CH)...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29217339/standardization-chemical-profiling-in%C3%A2-vitro-cytotoxic-effects-in%C3%A2-vivo-anti-carcinogenic-potential-and-biosafety-profile-of-indian-propolis
#3
Harshad Kapare, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
BACKGROUND: Propolis from apiculture is known for wide range of medicinal properties owing to its vast chemical constituents including polyphenols, flavonoids and anticancer agent Caffeic acid phenethyl ester (CAPE). OBJECTIVES: The objective of the study was to extract and standardize Indian propolis (IP) with respect to selected markers by newly developed High performance liquid chromatography (HPLC) method, to evaluate in vitro and in vivo anticancer activity and biosafety of Indian propolis...
December 4, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29214374/serum-antioxidant-parameters-are-significantly-increased-in-patients-with-type-2-diabetes-mellitus-after-consumption-of-chinese-propolis-a-randomized-controlled-trial-based-on-fasting-serum-glucose-level
#4
Weina Gao, Lingling Pu, Jingyu Wei, Zhanxin Yao, Yawen Wang, Tala Shi, Liting Zhao, Changya Jiao, Changjiang Guo
INTRODUCTION: Propolis is a natural product with many biological activities. The present study was designed to evaluate the effects of Chinese propolis on glucose metabolism, antioxidant function, and inflammatory cytokines in patients with type 2 diabetes mellitus (T2DM). METHODS: In the 18-week study, recruited T2DM patients were randomly divided into a Chinese propolis group (900 mg/day) (n = 31) and a control group (n = 30) according to fasting serum glucose levels at baseline...
December 6, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29202400/discovery-of-caffeic-acid-phenethyl-ester-derivatives-as-novel-myeloid-differentiation-protein-2-inhibitors-for-treatment-of-acute-lung-injury
#5
Lingfeng Chen, Yiyi Jin, Hongjin Chen, Chuchu Sun, Weitao Fu, Lulu Zheng, Min Lu, Pengqin Chen, Gaozhi Chen, Yali Zhang, Zhiguo Liu, Yi Wang, Zengqiang Song, Guang Liang
Myeloid differentiation protein 2 (MD2) is an essential molecule which recognizes lipopolysaccharide (LPS), leading to initiation of inflammation through the activation of Toll-like receptor 4 (TLR4) signaling. Caffeic acid phenethyl ester (CAPE) from propolis of honeybee hives could interfere interactions between LPS and the TLR4/MD2 complex, and thereby has promising anti-inflammatory properties. In this study, we designed and synthesized 48 CAPE derivatives and evaluated their anti-inflammatory activities in mouse primary peritoneal macrophages (MPMs) activated by LPS...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29197804/cytotoxicity-mechanisms-in-melanoma-cells-and-uplc-qtof-ms2-chemical-characterization-of-two-brazilian-stingless-bee-propolis-uncommon-presence-of-piperidinic-alkaloids
#6
Júlia Cisilotto, Louis P Sandjo, Larissa G Faqueti, Heloísa Fernandes, Débora Joppi, Maique W Biavatti, Tânia Beatriz Creczynski-Pasa
The present study characterized propolis extracts produced by Scaptotrigona bipunctata (Tubuna) and Melipona quadrifasciata (Mandaçaia) by LC-MS/MS; their cytotoxicity as well as the mechanism of action in a melanoma cellular model were also assessed. The chemical characterization performed by UPLC-ESI-QTOF/MS2 analysis revealed uncommon presence of piperidinic alkaloids in Tubuna's propolis extract together with C-glycopyranoside flavonoids. Mandaçaia's propolis collected in the same area rather presented terpenoids and flavonoids...
November 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29194657/a-proposal-to-create-an-extension-to-the-european-baseline-series
#7
Mark Wilkinson, Rosella Gallo, An Goossens, Jeanne D Johansen, Thomas Rustemeyer, Javier Sánchez-Pérez, Marie L Schuttelaar, Wolfgang Uter
BACKGROUND: The current European baseline series consists of 30 allergens, and was last updated in 2015. OBJECTIVES: To use data from the European Surveillance System on Contact Allergies (ESSCA) to propose an extension to the European baseline series in response to changes in environmental exposures. METHODS: Data from departmental and national extensions to the baseline series, together with some temporary additions from departments contributing to the ESSCA, were collated during 2013-2014...
December 1, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29175521/structural-analysis-of-the-interaction-between-free-glycated-and-fructated-hemoglobin-with-propolis-nanoparticles-a-spectroscopic-study
#8
Fatemeh Kazemi, Adeleh Divsalar, Ali Akbar Saboury
Non enzymatic Glycation is the main causes of diabetic complications. Propolis is a natural product of different plant exudates and buds which has different biological properties such as anti-hyperglycemia. In attention to better performance of nanoparticles in treatment, we synthesized propolis nanoparticles (PNP) and analyzed their physicochemical properties by dynamic light scattering (DLS), scanning electron microscopy (SEM), Zeta potential and FTIR analyses. Then, the structural changes of human hemoglobin (Hb), in three different forms of free, glycated and fructated Hb upon interaction with PNP at two temperatures of 25 and 37°C were investigated using fluorescence and far-UV circular dichoroism (CD) spectroscopic techniques...
November 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29172854/design-of-composite-microparticle-systems-based-on-pectin-and-waste-material-of-propolis-for-modified-l-alanyl-l-glutamine-release-and-with-immunostimulant-activity
#9
Mônica Villa Nova, Bianca A Ratti, Leandro S Herculano, Paulo R S Bittencourt, Cláudio R Novello, Roberto Barbosa Bazotte, Sueli de Oliveira Silva Lautenschlager, Marcos Luciano Bruschi
Catabolic conditions like acquired immunodeficiency syndrome, cancer and burn can cause immunosuppression. Amino acids such as alanine and glutamine are essential for the activity of the immune system. Propolis is immunostimulant and the waste of propolis extraction has been reused with technological and therapeutic purposes. Therefore, this study describes the association of propolis byproduct extract with pectin to prepare spray-dried microparticles containing the dipeptide L-alanyl-L-glutamine as stimulant systems of neutrophils...
November 27, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29162843/behavioral-responses-of-honey-bees-apis-mellifera-to-natural-and-synthetic-xenobiotics-in-food
#10
Ling-Hsiu Liao, Wen-Yen Wu, May R Berenbaum
While the natural foods of the western honey bee (Apis mellifera) contain diverse phytochemicals, in contemporary agroecosystems honey bees also encounter pesticides as floral tissue contaminants. Whereas some ubiquitous phytochemicals in bee foods up-regulate detoxification and immunity genes, thereby benefiting nestmates, many agrochemical pesticides adversely affect bee health even at sublethal levels. How honey bees assess xenobiotic risk to nestmates as they forage is poorly understood. Accordingly, we tested nine phytochemicals ubiquitous in nectar, pollen, or propolis, as well as five synthetic xenobiotics that frequently contaminate hives-two herbicides (atrazine and glyphosate) and three fungicides (boscalid, chlorothalonil, and prochloraz)...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29161583/chrysin-sources-beneficial-pharmacological-activities-and-molecular-mechanism-of-action
#11
REVIEW
Renuka Mani, Vijayakumar Natesan
In recent years, public and scientific interest in plant flavonoids has tremendously increased because of their postulated health benefits. This review was mainly focuses on the flavone chrysin (5,7-dihydroxyflavone), which occurs naturally in many plants, honey, and propolis. A number of in vitro and in vivo studies have revealed the therapeutic effects of chrysin against various diseases. In general, chrysin exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities...
November 18, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29141565/radio-modulatory-potential-ofcaffeic-acid-phenethyl-ester-a-therapeutic-perspective
#12
Km Anjaly, Ashu Tiku
Use of natural agents is an upcoming area of research in cancer biology. Caffeic acid phenethyl ester has received great attention because of its therapeutic potential in various conditions including cancer. It is an active/abundant component of propolis. Propolis is a honey bee hive product produced by bees using their enzyme-rich digestive secretions on resinous mix, bee wax and pollen from plants. It is used to protect the beehive against bacteria and other infections.Although a lot of work has been done on chemotherapeutic aspects of CAPE, its role as a radiomodulator is yet to be delineated...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29137160/the-influence-of-toothpaste-containing-australian-melaleuca-alternifolia-oil-and-ethanolic-extract-of-polish-propolis-on-oral-hygiene-and-microbiome-in-patients-requiring-conservative-procedures
#13
Tomasz Piekarz, Anna Mertas, Karolina Wiatrak, Rafał Rój, Patryk Kownacki, Joanna Śmieszek-Wilczewska, Ewelina Kopczyńska, Maciej Wrzoł, Maria Cisowska, Ewelina Szliszka, Zenon P Czuba, Iwona Niedzielska, Tadeusz Morawiec
The study was based on the use of a toothpaste with antiphlogistic activity, containing Australian Melaleuca alternifolia oil (tea tree oil-TTO) and ethanolic extract of Polish propolis (EEP). Fifty-one patients with varying conditions of the gingiva were divided into two groups. The study group received the toothpaste with TTO and EEP, while the control group received the same toothpaste but without TTO and EEP. Approximal plaque index (API), simplified oral hygiene index (OHI-s) and modified sulcus bleeding index (mSBI) were assessed in three subsequent stages...
November 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29135460/evaluation-of-the-antimicrobial-activity-and-cytotoxic-effect-of-hydroxyapatite-containing-brazilian-propolis
#14
Antonio Márcio Scatolini, Silvana Marina Piccoli Pugine, Luci Cristina de Oliveira Vercik, Mariza Pires de Melo, Eliana Cristina da Silva Rigo
The aim of this work was to produce hydroxyapatite powder (HA) containing dry extract of green and red propolis, and to evaluate possible bactericidal activity of the materials in a short period of time through a fast release system. The ethanolic extracts of green and red propolis (EEP) were incorporated into the material by spray drying. After release tests, powders containing dry EEP were characterized regarding the content of total phenolics and flavonoids. Materials characterization was made by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR)...
November 14, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29129989/inhibitory-effect-of-propolis-on-platelet-aggregation-in-vitro
#15
Yun-Xiang Zhang, Ting-Ting Yang, Liu Xia, Wei-Fen Zhang, Jia-Fu Wang, Ya-Ping Wu
Platelet hyperactivity plays an important role in arterial thrombosis and atherosclerosis. The present study was aimed to investigate the effects of different extracts of propolis and components of flavonoids on platelet aggregation. Platelet-rich plasma was prepared and incubated in vitro with different concentrations of the tested extracts and components of flavonoids. Platelets aggregation was induced by different agonists including adenosine diphosphate (ADP, 10 μM), thrombin receptor activator peptide (TRAP, 50 μM), and collagen (5 μg/mL)...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29120809/formulation-and-characterization-of-novel-nanostructured-lipid-carriers-made-from-beeswax-propolis-wax-and-pomegranate-seed-oil
#16
Yasamin Soleimanian, Sayed Amir Hossein Goli, Jaleh Varshosaz, Sayed Mohammad Sahafi
The objective of this study was to develop functional nanostructured lipid carriers (NLCs) using beeswax (BW), propolis wax (PW) and pomegranate seed oil (PSO). NLCs were prepared by a melt emulsification-ultra sonication technique. The influences of solid lipid composition, surfactant blend concentration (2, 4, and 6% of formulation) and PSO content (10, 30 and 50% of total lipid phase) were investigated. Statistical evaluations revealed that the formulation variables had significant effects on physical properties of NLC...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29117134/ginger-and-propolis-exert-neuroprotective-effects-against-monosodium-glutamate-induced-neurotoxicity-in-rats
#17
Usama K Hussein, Nour El-Houda Y Hassan, Manal E A Elhalwagy, Amr R Zaki, Huda O Abubakr, Kalyan C Nagulapalli Venkata, Kyu Yun Jang, Anupam Bishayee
Central nervous system cytotoxicity is linked to neurodegenerative disorders. The objective of the study was to investigate whether monosodium glutamate (MSG) neurotoxicity can be reversed by natural products, such as ginger or propolis, in male rats. Four different groups of Wistar rats were utilized in the study. Group A served as a normal control, whereas group B was orally administered with MSG (100 mg/kg body weight, via oral gavage). Two additional groups, C and D, were given MSG as group B along with oral dose (500 mg/kg body weight) of either ginger or propolis (600 mg/kg body weight) once a day for two months...
November 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29111193/antioxidant-and-diuretic-activity-of-co-administration-of-capparis-spinosa-honey-and-propolis-in-comparison-to-furosemide
#18
Soukaina El-Guendouz, Noori Al-Waili, Smail Aazza, Youssef Elamine, Soumia Zizi, Thia Al-Waili, Ali Al-Waili, Badiaa Lyoussi
OBJECTIVE: To study the antioxidant properties of Capparis spinosa (C. spinosa) honey and propolis and the effect of combined honey and propolis administration on urine volume and electrolytes in rats. METHODS: C. spinosa honey [1000 mg/kg body weight (b.wt)], propolis (100 mg/kg b.wt), honey/propolis mixture (C. spinosa honey 1000 mg/kg b.wt/ propolis extract 100 mg/kg b.wt ), distilled water (1 mL/kg b.wt) and furosemide (10 mg/kg b.wt) were orally administered to five groups of rats for 21 d...
October 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29104144/iraqi-propolis-increases-degradation-of-il-1%C3%AE-and-nlrc4-by-autophagy-following-pseudomonas-aeruginosa-infection
#19
Majid S Jabir, Ghassan M Sulaiman, Zainab J Taqi, Dong Li
Autophagy is a cellular process for maintaining cellular homeostasis. This process can be induced by different factors, such as immune stimuli and pathogen-associated molecules. Autophagy has an important role in the control of IL-1β secretion by macrophages and other cell types. In present study, we describe a novel role for Iraqi propolis affecting autophagy in controlling the secretion of IL-1β in bone-marrow macrophages (BMDMs). After infection with Pseudomonas aeruginosa in the presence of propolis, the degradation of IL-1β was induced, and the activity of inflammasome was reduced...
November 8, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29103419/marker-based-standardization-and-investigation-of-nutraceutical-potential-of-indian-propolis
#20
Nanaware Sadhana, Sathiyanarayanan Lohidasan, Kakasaheb Ramoo Mahadik
OBJECTIVE: Propolis, a resinous material collected by honey bees from various plants, has been explored globally for its medicinal and nutritional properties. However, research over Indian propolis is at infancy. This study was designed to investigate nutraceutical potential of Indian propolis. METHODS: In the present study, propolis extract was standardized with respect to markers caffeic acid phenethyl ester, caffeic acid, galangin, luteolin, curcumin, apigenin, pinocembrin and quercetin by new high-performance thin-layer chromatographic (HPTLC) methods...
November 2017: Journal of Integrative Medicine
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