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https://www.readbyqxmd.com/read/28631525/polyphenol-profile-by-uhplc-ms-ms-anti-glycation-antioxidant-and-cytotoxic-activities-of-several-samples-of-propolis-from-the-northeastern-semi-arid-region-of-brazil
#1
Jadriane de Almeida Xavier, Iara Barros Valentim, Fabiana O S Camatari, Alberto M M de Almeida, Henrique Fonseca Goulart, Jamylle Nunes de Souza Ferro, Emiliano de Oliveira Barreto, Bruno Coelho Cavalcanti, Carla B G Bottoli, Marília Oliveira Fonseca Goulart
CONTEXT: Propolis has promising biological activities. Propolis samples from the Northeast of Bahia, Brazil - sample A from Ribeira do Pombal and B, from Tucano - were investigated, with new information regarding their biological activities. OBJECTIVE: This paper describes the chemical profile, antioxidant, anti-glycation and cytotoxic activities of these propolis samples. MATERIAL AND METHODS: Ethanol extracts of these propolis samples (EEP) and their fractions were analyzed to determine total phenolic content (TPC); antioxidant capacity through DPPH(•), FRAP and lipid peroxidation; anti-glycation activity, by an in vitro glucose (10 mg/mL) bovine serum albumine (1 mg/mL) assay, during 7 d; cytotoxic activity on cancer (SF295, HCT-116, OVCAR-8, MDA-MB435, MX-1, MCF7, HL60, JURKAT, MOLT-4, K562, PC3, DU145) and normal cell lines (V79) at 0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28629133/propolis-diterpenes-as-a-remarkable-bio-source-for-drug-discovery-development-a-review
#2
REVIEW
Noushin Aminimoghadamfarouj, Alireza Nematollahi
Propolis is one of the complex, but valuable, bio-sources for discovering therapeutic compounds. Diterpenes are organic compounds composed of four isoprene units and are known for their biological and pharmacological characteristics, such as antibacterial, anticancer, and anti-inflammatory activities. Recently, advancements have been made in the development of antibacterial and anticancer leads from propolis-isolated diterpenes, and scrutiny of these compounds is being pursued. Thus, this review covers the progress in this arena, with a focus on the chemistry and biological activities of propolis diterpenes...
June 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28624363/brazilian-red-propolis-effects-on-peritoneal-macrophage-activity-nitric-oxide-cell-viability-pro-inflammatory-cytokines-and-gene-expression
#3
Bruno Bueno-Silva, Dione Kawamoto, Ellen S Ando-Suguimoto, Renato C V Casarin, Severino M Alencar, Pedro L Rosalen, Marcia P A Mayer
ETHNOPHARMACOLOGICAL RELEVANCE: Propolis has been used in folk medicine since ancient times and it presented inhibitory effect on neutrophil recruitment previously. However, its effect on macrophage obtained from mice remains unclear. AIM OF THE STUDY: to demonstrate BRP effects on LPS activated peritoneal macrophage. MATERIALS AND METHODS: Peritoneal macrophages, obtained from C57BL6 mice and activated with LPS, were treated with 50 to 80µg/mL of crude extract of Brazilian red propolis (BRP) during 48hours...
June 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28608666/-evaluation-of-the-effects-of-a-natural-dietary-supplement-with-cranberry-noxamicina%C3%A2-and-d-mannose-in-recurrent-urinary-infections-in-perimenopausal-women
#4
Vincenzo DE Leo, Valentina Cappelli, Maria G Massaro, Claudia Tosti, Giuseppe Morgante
BACKGROUND: The female genital apparatus, the urinary tract and the perineal supporting tissues share a common embryological origin, whose differentiation depends on the action of estrogens. In adult women, the progressive decline of the ovarian function, with the ensuing estrogen deprivation, reduces tissue tropism causing urogenital atrophy, which makes these organs much more susceptible to traumatisms and urinary infections. The disorders associated with changes in the urogenital tract of peri- and postmenopausal women have significant clinical relevance, both on account of their chronicity and high frequency of occurrence and on account of their having major repercussions on the quality of life of the women, who often have to call their doctor seeking relief for their symptoms...
August 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28603105/antibacterial-activity-of-propolis-extracts-from-the-south-of-portugal
#5
Ana Vanessa Oliveira, Ana Luisa Ferreira, Susana Nunes, Susana Anahi Dandlen, da Graca da Graca Miguel, Maria Leonor Faleiro
To examine the antibacterial activity of diverse extracts of propolis harvested at winter and spring from several locations of Algarve, Portugal, against Gram-negative and Gram-positive bacteria was the main goal of the present work. For such, the antibacterial activity was determined by agar diffusion. The results showed that all tested bacterial strains showed susceptibility to diluted propolis extracts and in a dose-dependent manner. Two propolis samples collected at springtime showed higher antibacterial activity, in comparison with samples harvested at wintertime...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28595483/comparative-studies-on-polyphenolic-profile-and-antimicrobial-activity-of-propolis-samples-selected-from-distinctive-geographical-areas-of-hungary
#6
Szabolcs Molnár, Kata Mikuska, Katalin Patonay, Krisztina Sisa, Hussein G Daood, Erzsébet Némedi, Attila Kiss
The present paper reports about a comparative survey on the chemical composition, antioxidant activity and in vitro antimicrobial activity of selected propolis samples collected in Hungary. The total levels of polyphenolic compounds including flavonoids in ethanolic extracts of propolis were assessed. The major constituents of ethanolic extracts of propolis were analysed by gas chromatography/mass spectrometry analysis. Total phenolic content was determined spectrophotometrically using a Folin-Ciocalteu reagent...
June 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28591241/the-anti-caries-activity-and-toxicity-of-an-experimental-propolis-containing-varnish
#7
Mariana Passos DE Luca, Irlan Almeida Freires, Alfonso Gala-García, Vagner Rodrigues Santos, Miriam Pimenta Vale, Severino Matias de Alencar, Pedro Luiz Rosalen
We investigated the anti-caries effects of an experimental propolis varnish in vivo, and further tested its toxicity against fibroblasts. Fifty-six SPF female Wistar rats were infected with Streptococcus mutans UA159 (SM) and allocated into four groups (n = 14/group): G1, propolis varnish (15%/PV); G2, chitosan varnish (CV/vehicle); G3, gold standard (GS/Duraphat®); and G4, untreated. The animals received a single varnish application on their molars and were submitted to a high cariogenic challenge (Diet-2000, 56% sucrose, and 5% sucrose-added water, ad libitum) for 4 weeks...
June 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28588226/the-effects-of-brazilian-green-propolis-that-contains-flavonols-against-mutant-copper-zinc-superoxide-dismutase-mediated-toxicity
#8
Tomoyuki Ueda, Masatoshi Inden, Katsuhiro Shirai, Shin-Ichiro Sekine, Yuji Masaki, Hisaka Kurita, Kenji Ichihara, Takashi Inuzuka, Isao Hozumi
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. The purpose of this study was to clarify effects of brazilian green propolis and the active ingredient against ALS-associated mutant copper-zinc superoxide dismutase (SOD1)-mediated toxicity. Ethanol extract of brazilian green propolis (EBGP) protected N2a cells against mutant SOD1-induced neurotoxicity and reduced aggregated mutant SOD1 by induction of autophagy. Kaempferide and kaempferol, the active ingredients of EBGP, also inhibited mutant SOD1-induced cell death and reduced the intracellular mutant SOD1 aggregates...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28587122/anti-inflammatory-properties-of-brazilian-green-propolis-encapsulated-in-a-%C3%AE-cyclodextrin-complex-in-mice-fed-a-western-type-diet
#9
Gerald Rimbach, Alexandra Fischer, Anke Schloesser, Gerold Jerz, Naoko Ikuta, Yoshiyuki Ishida, Ryota Matsuzawa, Seiichi Matsugo, Patricia Huebbe, Keiji Terao
Ageing is often accompanied by chronic inflammation. A fat- and sugar-rich Western-type diet (WTD) may accelerate the ageing phenotype. Cell culture studies have indicated that artepillin C-containing Brazilian green propolis exhibits anti-inflammatory properties. However, little is known regarding its anti-inflammatory potential in mouse liver in vivo. In this study, female C57BL/6NRj wild-type mice were fed a WTD, a WTD supplemented with Brazilian green propolis supercritical extract (GPSE) encapsulated in γ-cyclodextrin (γCD) or a WTD plus γCD for 10 weeks...
May 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28578886/antibacterial-properties-of-chitosan-nanoparticles-and-propolis-associated-with-calcium-hydroxide-against-single-and-multispecies-biofilms-an-in%C3%A2-vitro-and-in-situ-study
#10
Aldo Del Carpio-Perochena, Anil Kishen, Rafael Felitti, Anjali Y Bhagirath, Manoj R Medapati, Christopher Lai, Rodrigo S Cunha
INTRODUCTION: The aim of this study was to evaluate the efficacy of chitosan nanoparticles (CNPs) and ethanolic propolis extract (EPE) incorporated into a calcium hydroxide paste (Ca[OH]2) to kill bacterial biofilms. METHODS: Human root canal dentin was infected with Enterococcus faecalis for 21 days and also intraorally for 48 hours followed by incubation in brain-heart infusion for 48 hours to standardize biofilm growth. Ca(OH)2 pastes associated or not with CNPs or EPE were tested on biofilms for 7 and 14 days...
June 1, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28565752/hepatoprotective-activity-of-chrysin-is-mediated-through-tnf-%C3%AE-in-chemically-induced-acute-liver-damage-an-in-vivo-study-and-molecular-modeling
#11
Anca Hermenean, Teodora Mariasiu, Inmaculada Navarro-González, Josefina Vegara-Meseguer, Eftimie Miuțescu, Sandipan Chakraborty, Horacio Pérez-Sánchez
Chrysin (5,7-dihydroxyflavone) is a naturally occurring flavonoid present at high levels in honey, propolis and numerous plant extracts. Chrysin is known to have hepatoprotective activity, however, the mechanisms by which it exerts this effect remain unclear. In the present study, the effects of chrysin in carbon tetrachloride (CCl4)-induced acute liver damage were investigated and the results used to infer a possible mechanism behind chrysin's hepatoprotective activity. Prior to an intraperitoneal injection of CCl4 (1 ml/kg) to induce acute liver damage, chrysin (50 mg/kg) was administered orally to mice for 7 days...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28561958/identification-of-free-radical-scavengers-from-brazilian-green-propolis-using-off-line-hplc-dpph-assay-and-lc-ms
#12
Cuiping Zhang, Xiaoge Shen, Jiawei Chen, Xiasen Jiang, FuLiang Hu
Brazilian green propolis is known as an appreciable natural antioxidant with abundant polyphenolic compounds. For quality control, a fingerprint-efficacy study of Brazilian green propolis was carried out in this work. Chemical fingerprints of Brazilian green propolis from 22 different sources were determined by HPLC and investigated by similarity analysis. The fingerprint-efficacy relationships between chemical fingerprint and DPPH radical-scavenging activity were established. The results showed that 14 characteristic common peaks were identified, and 9 compounds were discovered with free radical-scavenging activities...
May 31, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28560780/double-blind-randomized-phase-iii-study-comparing-a-mixture-of-natural-agents-versus-placebo-in-the-prevention-of-acute-mucositis-during-chemoradiotherapy-for-head-and-neck-cancer
#13
Laura Marucci, Alessia Farneti, Paolo Di Ridolfi, Paola Pinnaro, Raul Pellini, Diana Giannarelli, Patrizia Vici, Mario Conte, Valeria Landoni, Giuseppe Sanguineti
BACKGROUND: There is no widely accepted intervention in the prevention of acute mucositis during chemoradiotherapy for head and neck carcinoma. In the present double-blind study, we tested 4 natural agents, propolis, aloe vera, calendula, and chamomile versus placebo. METHODS: Patients undergoing concomitant chemo-intensity-modulated radiotherapy (IMRT) were given natural agent or matched placebo; grade 3 mucositis on physical examination according to Common Terminology Criteria for Adverse Events (CTCAE) version 3...
May 31, 2017: Head & Neck
https://www.readbyqxmd.com/read/28560054/antibacterial-activity-against-streptococcus-mutans-and-inhibition-of-bacterial-induced-enamel-demineralization-of-propolis-miswak-and-chitosan-nanoparticles-based-dental-varnishes
#14
Mariem O Wassel, Mona A Khattab
Using natural products can be a cost-effective approach for caries prevention especially in low income countries where dental caries is highly prevalent and the resources are limited. Specially prepared dental varnishes containing propolis, miswak, and chitosan nanoparticles (CS-NPs) with or without sodium fluoride (NaF) were assessed for antibacterial effect against Streptococcus mutans (S. mutans) using disk diffusion test. In addition, the protective effect of a single pretreatment of primary teeth enamel specimens against in vitro bacterial induced enamel demineralization was assessed for 3 days...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28558440/chemical-composition-and-antimicrobial-activities-of-iranian-propolis
#15
Houshang Afrouzan, Tahghighi Azar, Sedigheh Zakeri, Es-haghi Ali
Background: With considering the importance of natural products for their remedial and therapeutic value, this research was aimed to analyze the chemical compositions and antimicrobial activity of four propolis samples from different areas of Iran (Chenaran, Taleghan, Morad Beyg, and Kalaleh) with various climates and flora. Methods: ethanolic (70% EtOH) and dichlromethane (DCM) extracts of Iranian propolis were analyzed by gas chromatography-mass spectrometry (GC-MS) methods, and antimicrobial activity was evaluated against Candida albicans, Escherichia coli, and Staphylococcus aureus using disk diffusion antimicrobial method...
May 31, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28556278/acceptability-of-beehive-products-as-ingredients-in-quinoa-bars
#16
Francisco Rios, Manuel Lobo, Norma Samman
BACKGROUND: The aim of this work was to develop a puffed quinoa bar with beehive products of high content of phenolic compounds, based on acceptability and perception of consumers. A rotational central composite design of three variables (honey, pollen and propolis) was used for food product formulation. The responses to optimize were sensorial acceptability and polyphenol content. Next to acceptability a CATA test was performed with 115 consumers. Preference maps were used to relate acceptability and sensorial attributes of bars that cause rejection or acceptance...
May 29, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28547940/cytotoxic-activity-of-propolis-extracts-from-the-stingless-bee-trigona-sirindhornae-against-primary-and-metastatic-head-and-neck-cancer-cell-lines
#17
Kusumawadee Utispan, Bordin Chitkul, Sittichai Koontongkaew
Background: Propolis, a resinous substance produced by the honeybee, has a wide spectrum of potent biological activities. However, anti-cancer activity of propolis obtained from Trigona sirindhornae, a new species of stingless bee, has not yet been reported. This study concerned cytotoxicity of propolis extracts from T. sirindhornae against two head and neck squamous cell carcinoma (HNSCC) cell lines. Materials and Methods: A dichloromethane extract of propolis (DMEP) was prepared generating 3 fractions: DMEP-A, DMEP-B, and DMEP-C...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545669/are-russian-propolis-ethanol-extracts-the-future-for-the-prevention-of-medical-and-biomedical-implant-contaminations
#18
Ashwin Ambi, Julia Bryan, Katherine Borbon, Daniel Centeno, Tianchi Liu, Tung Po Chen, Thomas Cattabiani, Christian Traba
BACKGROUND: Most studies reveal that the mechanism of action of propolis against bacteria is functional rather than structural and is attributed to a synergism between the compounds in the extracts. HYPOTHESIS/PURPOSE: Propolis is said to inhibit bacterial adherence, division, inhibition of water-insoluble glucan formation, and protein synthesis. However, it has been shown that the mechanism of action of Russian propolis ethanol extracts is structural rather than functional and may be attributed to the metals found in propolis...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28539963/the-role-of-propolis-in-oxidative-stress-and-lipid-metabolism-a-randomized-controlled-trial
#19
Verónica Mujica, Roxana Orrego, Jorge Pérez, Paula Romero, Paz Ovalle, Jessica Zúñiga-Hernández, Miguel Arredondo, Elba Leiva
Although there is evidence of the benefits of propolis on human health, the vast majority of studies have been conducted using animal models. The present study includes the chemical characterization and clinical evaluation of the effects of the oral administration of propolis solution on the oxidative status and modulation of lipids in a human population in Talca, Chile. Chemical characterization of propolis, total phenol, flavonoids, and total antioxidant capacity were determined by ORAC. Identification of phenols and flavonoids in propolis was assessed by HPLC-DAD...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28528363/caffeic-acid-phenethyl-ester-is-protective-in-experimental-ulcerative-colitis-via-reduction-in-levels-of-pro-inflammatory-mediators-and-enhancement-of-epithelial-barrier-function
#20
Mohammed N Khan, Majella E Lane, Paul A McCarron, Murtaza M Tambuwala
BACKGROUND: Inhibition of the nuclear factor kappa beta (NF-κβ) pathway has been proposed as a therapeutic target due to its key role in the expression of pro-inflammatory genes, including pro-inflammatory cytokines, chemokines, and adhesion molecules. Caffeic acid phenethyl ester (CAPE) is a naturally occurring anti-inflammatory agent, found in propolis, and has been reported as a specific inhibitor of NF-κβ. However, the impact of CAPE on levels of myeloperoxidases (MPO) and pro-inflammatory cytokines during inflammation is not clear...
May 20, 2017: Inflammopharmacology
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