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Satoshi Endo, Manami Hoshi, Toshiyuki Matsunaga, Takahiro Inoue, Kenji Ichihara, Akira Ikari
Propolis, a resinous substance produced by honeybees, possesses various biological actions including anticancer activity towards tumor cells. Recently, the ethanol extract of Brazilian green propolis has been shown to induce autophagy, which is known to be induced in treatment of cancer cells with anticancer drugs, leading to cancer cell survival and decreased sensitivity to anticancer agents. In this study, we aimed to identify autophagy-inducing components of the propolis and elucidated the reciprocal relationship between anticancer cytotoxicity and protective autophagy in prostate cancer CWR22Rv1 cells...
February 13, 2018: Biochemical and Biophysical Research Communications
Lizziane de Francisco, Diana Pinto, Hélen Rosseto, Lucas Toledo, Rafaela Santos, Flávia Tobaldini-Valério, Terezinha Svidzinski, Marcos Bruschi, Bruno Sarmento, M Beatriz P P Oliveira, Francisca Rodrigues
Propolis is a natural adhesive resinous compound produced by honeybees to protect hives from bacteria and fungi, being extremely expensive for food industry. During propolis production, a resinous by-product is formed. This resinous waste is currently undervalued and underexploited. Accordingly, in this study the proximate physical and chemical quality, as well as the antioxidant activity, radical scavenging activity and cell viability of this by-product were evaluated and compared with propolis in order to boost new applications in food and pharmaceutical industries...
March 2018: Food Research International
Aynur Sahin, Suha Turkmen, Nizamettin Guzel, Ahmet Menteşe, Suleyman Turedi, Suleyman Caner Karahan, Esin Yulug, Selim Demir, Osman Aynaci, Orhan Deger, Abdulkadir Gunduz
OBJECTIVES: Delayed healing and non-union of fractures have a significant effect upon patient morbidity. Studies have therefore largely concentrated on accelerating fracture healing. This study was intended to compare the effect of "mad honey" and propolis on fracture healing using radiological and histopathological analysis. SUBJECTS AND METHODS: Femur fracture was surgically performed on 48 rats, followed by fixation. Animals were then divided into eight groups; two control groups (15- and 30-day) and six treatment groups (15- and 30-day normal honey, 15- and 30-day "mad honey" and 15- and 30-day propolis)...
February 11, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Mahmoud S Sherif, Taha A Rehab, Zayed A Hamdia, Vladmir P Torchilin
Natural products are invaluable resource of anticancer drug discovery. They generally viewed as safe but weak, within the framework of nanotechnology, they can serve as template for potent anticancer drugs. We first evaluated the cytotoxic activity of different propolis extracts (water, 70% ethanol, absolute ethanol and hexane) in many cancer cell lines, then the solid nanoparticles from the organic solvent extracts were prepared and their cytotoxicity was evaluated as well. Finally, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes were prepared from the most cytotoxic organic solvent extract and their cytotoxicity was also evaluated...
January 2018: General Physiology and Biophysics
P Pasinska, K Kowalska, E Klimiec, A Szyper-Maciejowska, A Wilk, A Klimkowicz-Mrowiec
Delirium is the most common and serious neurobehavioral complication in acute hospital admissions. Some patients develop signs of delirium but do not meet all diagnostic criteria. Stroke is a major risk factor for delirium. The aim of this prospective study was to build a predictive model for delirium and subsyndromal post-stroke delirium. Patients with stroke were screened for delirium during the first 7 days after admission. Delirium was diagnosed according to DSM-V criteria. Baseline demographic, biochemical, stroke-related data, medications used, neurological deficit, and premorbid cognitive and functional impairment were assessed...
February 8, 2018: Journal of Neurology
Silvia Laura Guzmán-Gutiérrez, Antonio Nieto-Camacho, Jorge Ivan Castillo-Arellano, Elizabeth Huerta-Salazar, Griselda Hernández-Pasteur, Mayra Silva-Miranda, Omar Argüello-Nájera, Omar Sepúlveda-Robles, Clara Inés Espitia, Ricardo Reyes-Chilpa
The propolis produced by bees are used in alternative medicine for treating inflammation, and infections, presumably due to its antioxidant properties. In this context, five propolis from México were investigated to determine their inhibitory lipid peroxidation properties. The ethyl acetate extract from a red propolis from Chiapas State (4-EAEP) was the most potent (IC50 = 1.42 ± 0.07 μg/mL) in the TBARS assay, and selected for further studies. This extract afforded two new compounds, epoxypinocembrin chalcone (6), and an ε-caprolactone derivative (10), as well as pinostrobin (1), izalpinin (2), cinnamic acid (3), pinocembrin (4), kaempherol (5), 3,3-dimethylallyl caffeate in mixture with isopent-3-enyl caffeate (7a + 7b), 3,4-dimethoxycinnamic acid (8), rhamnetin (9) and caffeic acid (11)...
February 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Isabel Martínez Pallás, Claudia Conejero Del Mazo, Lucía Prieto Torres
No abstract text is available yet for this article.
February 7, 2018: Contact Dermatitis
Erika Tayse da Cruz Almeida, Maria Cristina Delgado da Silva, José Marcos Dos Santos Oliveira, Regianne Umeko Kamiya, Rodolfo Elleson Dos Santos Arruda, Danilo Abreu Vieira, Valdemir da Costa Silva, Pierre Barnabé Escodro, Irinaldo Diniz Basílio-Júnior, Ticiano Gomes do Nascimento
The aim of this study was to characterize tinctures and microcapsules loaded with an ethanol extract of red propolis through chemical, physicochemical and microbiological assays in order to establish quality control tools for nutraceutical preparations of red propolis. The markers (isoflavonoids, chalcones, pterocarpans, flavones, phenolic acids, terpenes and guttiferones) present in the tinctures A and B were identified and confirmed using LC/ESI/FTMS/Orbitrap. Four compositions (A, B, C and D) were prepared to contain B tincture of the red propolis with some pharmaceutical excipients and submitted to two drying processes, i...
October 2017: Journal of Pharmaceutical Analysis
Rashmi Baranwal, Vijay Duggi, Alok Avinash, Alok Dubey, Sulabh Pagaria, Harsha Munot
Introduction: One of the most important factors for successful endodontic therapy is root canal cleaning. The difficulty involved in eliminating microorganisms, as well as their residual presence, warrants the use of root canal dressings after bio-mechanical preparation. Aim: The aim of the study was to compare the diffusion ability between nonalcoholic calcium hydroxide-propolis paste, calcium hydroxide-saline paste, and calcium hydroxide-propylene glycol paste...
October 2017: International Journal of Clinical Pediatric Dentistry
Priyanshu Bhargava, Abhinav Grover, Nupur Nigam, Ashish Kaul, Motomichi Doi, Yoshiyuki Ishida, Hanzo Kakuta, Sunil C Kaul, Keiji Terao, Renu Wadhwa
Propolis, a resinous substance collected by honeybees by mixing their saliva with plant sources, including tree bark and leaves and then mixed with secreted beeswax, possesses a variety of bioactivities. Whereas caffeic acid phenethyl ester (CAPE) has been recognized as a major bioactive ingredient in New Zealand propolis, Brazilian green propolis, on the other hand, possesses artepillin C (ARC). In this study, we report that, similar to CAPE, ARC docks into and abrogates mortalin-p53 complexes, causing the activation of p53 and the growth arrest of cancer cells...
January 22, 2018: International Journal of Oncology
Yoshiyuki Ishida, Ran Gao, Navjot Shah, Priyanshu Bhargava, Takahiro Furune, Sunil C Kaul, Keiji Terao, Renu Wadhwa
Besides honey, honeybees make a sticky substance (called propolis/bee glue) by mixing saliva with poplar tree resin and other botanical sources. It is known to be rich in bioactivities of which the anticancer activity is most studied. Caffeic acid phenethyl ester (CAPE) is a key anticancer component in New Zealand propolis. We have earlier investigated the molecular mechanism of anticancer activity in CAPE and reported that it activates DNA damage signaling in cancer cells. CAPE-induced growth arrest of cells was mediated by downregulation of mortalin and activation of p53 tumor suppressor protein...
January 1, 2018: Integrative Cancer Therapies
Ângela Sena-Lopes, Francisco Silvestre Brilhante Bezerra, Raquel Nascimento das Neves, Rodrigo Barros de Pinho, Mara Thais de Oliveira Silva, Lucielli Savegnago, Tiago Collares, Fabiana Seixas, Karine Begnini, João Antonio Pêgas Henriques, Mariana Roesch Ely, Luciane C Rufatto, Sidnei Moura, Thiago Barcellos, Francine Padilha, Odir Dellagostin, Sibele Borsuk
Most studies of Brazilian red propolis have explored the composition and biological properties of its ethanolic extracts. In this work, we chemically extracted and characterized the essential oil of Brazilian red propolis (EOP) and assessed its adjuvant, antiparasitic and cytotoxic activities. The chemical composition of EOP was analyzed using gas chromatography with mass spectrometry (GC-MS). EOP was tested for in vitro activity against Trichomonas vaginalis (ATCC 30236 isolate); trophozoites were treated with different concentrations of EOP (ranging from 25 to 500 μg/mL) in order to establish the MIC and IC50 values...
2018: PloS One
M E Galarraga-Vinueza, J Mesquita-Guimarães, R S Magini, J C M Souza, M C Fredel, A R Boccaccini
The aim the present study was to evaluate the chemical reactivity of 58S mesoporous bioactive glass (MBG) particles in as-synthesized condition and after embedding propolis and cranberry antibiofilm compounds at different concentrations. MBG 58S was synthesized by alkali sol-gel method with the addition of the triblock pluronic copolymer P123 as surfactant. Samples were characterized by physco-chemical properties measurement, N2 adsorption/desorption analysis, and field emission scanning electron microscopy (FESEM) observations...
January 29, 2018: Journal of Biomedical Materials Research. Part A
Bruno Dias Nani, Marcelo Franchin, Josy Goldoni Lazarini, Irlan Almeida Freires, Marcos Guilherme da Cunha, Bruno Bueno-Silva, Severino Matias de Alencar, Ramiro Mendonça Murata, Pedro Luiz Rosalen
Vestitol and neovestitol are bioactive isoflavonoids isolated from Brazilian red propolis, a unique Apis melifera type of propolis botanically originated from Dalbergia ecastophyllum. Although these molecules have relevant biological effects, including anticancer and immunomodulatory activities, their mechanism(s) of action and the affected pathways remain largely unknown. Here, we carried out a pharmacogenomic analysis to investigate the effects of vestitol and neovestitol on the whole-genome expression in human tumor cells, particularly cancer-related target proteins...
January 29, 2018: Phytotherapy Research: PTR
Taichi Mitsui, Sho Hotta, Shigemi Tazawa, Yasuko Arai, Kenji Kato, Kenji Ichihara
A novel 2-phenoxychromone (1) and five known flavones (2-6) were isolated from northeastern Brazilian propolis in the state of Bahia. The chemical structures of these six compounds were determined by spectroscopic investigations and single-crystal X-ray analysis. The isolated compounds showed growth-inhibitory activities, in varying degrees, against human tumor cell lines. This is the first report on the discovery of a novel 2-phenoxychromone from propolis.
January 26, 2018: Bioscience, Biotechnology, and Biochemistry
Rita López-Cabanillas, Ronal Huayanay-Conde, Cinthya Gonzales, Mahli Maguiña, Italo Granados, Mila Ccasani, Astrid Laguna, Ernesto León, Nuria Romero-Caballero, Jessenia Chacón
OBJECTIVES: To determine the antiurolytic activity of the ethanolic extract of Ayacuchan propolis in a preventive model of urolithiasis in rats. MATERIALS AND METHODS: A total of 45 male Sprague-Dawley albino rats were studied. The antiurolithic effect was analyzed in five groups of six animals each: blank, control (treated with 1 mL of 5% ethylene glycol and 1 mL of 5% ammonium chloride), and three experimental groups (treated with the ethanol extract of propolis at a daily dose of 250, 350, and 500 mg/kg, respectively)...
October 2017: Revista Peruana de Medicina Experimental y Salud Pública
Daiane Heidrich, Carmen Beatriz Borges Fortes, Aline Taís Mallmann, Clarissa Machado Vargas, Paula Borges Arndt, Maria Lúcia Scroferneker
PURPOSE: To evaluate the in vitro activity of 8% rosemary, 2% castor oils, and 12% propolis glycolic extract against Candida albicans, as well as the physical changes of properties in colorless and pink acrylic resins after immersion in these liquids. MATERIALS AND METHODS: Colorimetric, roughness, and Knoop microhardness assays were evaluated in 25 specimens distributed into five groups (3 test groups and 2 control groups - distilled water and hypochlorite 1%), totaling five specimens per group for each acrylic resin (colorless and pink)...
January 11, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Hassiba Rouibah, Lahouel Mesbah, Wided Kebsa, Malek Zihlif, Mamoun Ahram, Bachaer Aburmeleih, Ibtihal Mostafa, Hemzeh El Amir
BACKGROUND: Pancreatic cancer is one of the most aggressive and lethal cancer, with poor prognosis and high resistant to current chemotherapeutic agents. Therefore, new therapeutic strategies and targets are underscored. Propolis has been reported to exhibit a broad spectrum of biological activities including anticancer activity. OBJECTIVE: This study was carried out to assess the possible efficacy of Algerian propolis on the antitumor effect of doxorubicin on human pancreatic cancer cell line (PANC-1)...
January 10, 2018: Anti-cancer Agents in Medicinal Chemistry
Irlan Almeida Freires, Gustavo Machado Santaella, Janaina de Cássia Orlandi Sardi, Pedro Luiz Rosalen
OBJECTIVES: This systematic review was carried out to identify which naturally-occurring agents and constituents isolated therefrom have effects in preventing bone loss in a ligature-induced periodontitis model. MATERIALS AND METHODS: Eight databases were systematically searched for studies of experimental periodontitis. The data were extracted, analyzed, and the treatment outcomes were given scores based on the level of bone destruction as compared to their untreated induced-periodontitis control...
December 27, 2017: Archives of Oral Biology
Nayara Cristina Alves de Lima, Bianca Altrao Ratti, Patrícia de Souza Bonfim Mendonça, Gilson Murata, Raphaela Regina Araujo Pereira, Celso Vataru Nakamura, Marcia Edilaine Lopes Consolaro, Terezinha Inez Estivalet Svidzinski, Elaine Hatanaka, Marcos Luciano Bruschi, Sueli de Oliveira Silva
AIM: To investigate whether Brazilian green propolis improves the immune response against recurrent form isolate recurrent vulvovaginal candidiasis (RVVC) caused by Candida albicans by increasing neutrophil oxidative burst. MATERIALS & METHODS: We evaluated oxidant species production, oxygen consumption, microbicidal activity and myeloperoxidase activity in neutrophils previously treated with propolis and activated with different isolates of C. albicans (RVVC), vulvovaginal candidiasis, asymptomatic isolates and the reference strain...
January 5, 2018: Future Microbiology
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