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Nayanna de Oliveira Ramos Melo, Camila de Carvalho Juanes, Mayara Freire de Alencar Alves, Emiliano Tiago Melo Silva, Francisco Vagnaldo Fechine Jamacaru, Telma Leda Gomes de Lemos, Conceição Aparecida Dornelas
PURPOSE: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. METHODS: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg/kg, GIII and GVII: 1% gum arabic 5 mL/kg, GIV and GVIII: distilled water 5 mL/kg)...
May 2018: Acta Cirúrgica Brasileira
Flavia F Veiga, Marina C Gadelha, Marielen R T da Silva, Maiara I Costa, Brenda Kischkel, Lidiane V de Castro-Hoshino, Francielle Sato, Mauro L Baesso, Morgana F Voidaleski, Vanessa Vasconcellos-Pontello, Vânia A Vicente, Marcos L Bruschi, Melyssa Negri, Terezinha I E Svidzinski
Onychomycosis is a chronic fungal infection of nails, commonly caused by dermatophyte fungi, primarily species of Trichophyton . Because of the limited drug arsenal available to treat general fungal infections and the frequent failure of onychomycosis treatment, the search for new therapeutic sources is essential, and topical treatment with natural products for onychomycosis has been encouraged. Propolis, an adhesive resinous compound produced by honeybees ( Apis mellifera ), has shown multiple biological properties including significant antifungal and anti-biofilm activities in vitro ...
2018: Frontiers in Microbiology
Katarzyna Gucwa, Barbara Kusznierewicz, Sławomir Milewski, Patrick Van Dijck, Piotr Szweda
The aim of our work was to check if one of the products of natural origin, namely honey bee propolis, may be an alternative or supplement to currently used antifungal agents. The activity of 50 ethanolic extracts of propolis (EEPs), harvested in Polish apiaries, was tested on a group of 69 clinical isolates of C. albicans . Most of the EEPs showed satisfactory activity, with minimum fungicidal concentrations (MFC) mainly in the range of 0.08⁻1.25% ( v / v ). Eradication of biofilm from polystyrene microtitration plates in 50% (MBEC50 , Minimum Biofilm Eradication Concentration) required concentrations in the range of 0...
June 19, 2018: Pathogens
Abdolhamid Meimandi-Parizi, Ahmad Oryan, Emad Sayahi, Amin Bigham-Sadegh
BACKGROUND: propolis is known for its antioxidant, immune response modulating, and wound healing effects. In the present study in order to determine the bone healing capacity of the propolis extract, a critical sized, nonunion, radial bone defect model was repaired in rat, using chitosan and demineralized bone matrix (DBM) scaffolds along with propolis extract. MATERIALS AND METHODS: Seventy-two radial bone defects in 36 healthy male rats were randomly divided into 6 groups (n= 12/group)...
June 11, 2018: International Journal of Surgery
Yueh-Ming Lin, Chih-I Chen, Yi-Ping Hsiang, Yung-Chia Hsu, Kung-Chuan Cheng, Pei-Hsuan Chien, Hsiao-Lin Pan, Chien-Chang Lu, Yun-Ju Chen
Chemotherapeutic 5-fluorouracil (5-FU) combined with oxaliplatin is often used as the standard treatment for colorectal cancer (CRC). The disturbing side effects and drug resistance commonly observed in chemotherapy motivate us to develop alternative optimal therapeutic options for CRC treatment. Chrysin, a natural and biologically active flavonoid abundant in propolis, is reported to have antitumor effects on a few CRCs. However, whether and how chrysin achieves similar effectiveness to the 5-FU combination is not clear...
June 14, 2018: International Journal of Molecular Sciences
Kai Wang, Xiaolu Jin, Qiangqiang Li, Alexandra Christine Helena Frankland Sawaya, Richard K Le Leu, Michael A Conlon, Liming Wu, Fuliang Hu
SCOPE: Dietary supplementation with polyphenol-rich propolis can protect against experimentally-induced colitis. We examined whether different polyphenol compositions of Chinese propolis (CP) and Brazilian propolis (BP) influences their ability to protect against dextran sulfate sodium (DSS)-induced colitis in rats. METHODS AND RESULTS: HPLC-DAD/Q-TOF-MS analysis confirmed that polyphenol compositions of CP and BP were dissimilar. Rats were given CP or BP by gavage (300 mg/kg body weight) throughout the study, starting 1 week prior to DSS treatment for 1 week followed by 3 d without DSS...
June 11, 2018: Molecular Nutrition & Food Research
Marcel Nani, Andréia Leone, Vinícius Pedro Bom, Andrei Felipe Buszinski, Rebeca Oliveira de Souza, Vanessa Alves Pinheiro, Panagiota Danapoulos, Rosita Swikidisa, Franciane Marquele-Oliveira, Marco Andrey Cipriani Frade, Andresa Aparecida Berretta, Rodrigo José Lupatini Nogueira
Several previous studies have demonstrated improved wound healing associated with natural-based formulations. Therefore, the purpose of this study was to assess the efficacy of a topical formulation containing both a Brazilian micronized propolis extract and a Peucedanum ostruthium leaf extract for the treatment of wounds created by surgical punch in rats. The study was conducted for 14 days and animals were treated as follows: gauze group (G), polyethylene glycol base ointment (Control), AlpaWash (an ointment containing a Brazilian micronized propolis extract and Peucedanum ostruthium leaf extract [Treatment]), and polysporin (one of the most commonly used topical antibiotic ointments, based on bacitracin zinc and polymyxin B sulfate [Reference Standard])...
March 2018: International Journal of Pharmaceutical Compounding
Philip Donkersley, Glenn Rhodes, Roger W Pickup, Kevin C Jones, Kenneth Wilson
Microbial communities, associated with almost all metazoans, can be inherited from the environment. Although the honeybee ( Apis mellifera L.) gut microbiome is well documented, studies of the gut focus on just a small component of the bee microbiome. Other key areas such as the comb, propolis, honey, and stored pollen (bee bread) are poorly understood. Furthermore, little is known about the relationship between the pollinator microbiome and its environment. Here we present a study of the bee bread microbiome and its relationship with land use...
May 2018: Ecology and Evolution
Agharid El-Gammal, Veronica Di Nardo, Farah Daaboul, Georgi Tchernev, Uwe Wollina, Jacopo Lotti, Torello Lotti
BACKGROUND: Apitherapy is the medical use of honey bee products (honey, propolis, royal jelly, bee wax, and bee venom) to relieve human ailments, propolis in particularly, rich in essential oils such as flavonoid. Propolis is derived from tree buds and plants. It is considered as one of the most well-documented products from the honeybee and has always played an important role in traditional folk medicine. Another renowned plant is Aloe vera appertaining to the Liliaceae family. Its mucilaginous gel has been extensively used in many cultures for its apparent effectiveness in treating wounds, burns, itchiness and hair loss...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
Priyanshu Bhargava, Anjani Kumari, Jayarani F Putri, Yoshiyuki Ishida, Keiji Terao, Sunil C Kaul, Durai Sundar, Renu Wadhwa
Honeybee propolis and its bioactive component, caffeic acid phenethyl ester (CAPE), are known for a variety of therapeutic potentials. By recruiting a cell-based reporter assay for screening of hypoxia-modulating natural drugs, we identified CAPE as a pro-hypoxia factor. In silico studies were used to probe the capacity of CAPE to interact with potential hypoxia-responsive proteins. CAPE could not dock into hypoxia inducing factor (HIF-1), the master regulator of hypoxia response pathway. On the other hand, it was predicted to bind to factor inhibiting HIF (FIH-1)...
June 4, 2018: Cell Stress & Chaperones
Raquel Pantarotto Souza, Patricia de Souza Bonfim-Mendonca, Gabrielle Marconi Zago Ferreira Damke, Analine Rosa Barquez De Assis Carvalho, Bianca Altrao Ratti, Djaceli Sampaio de Oliveira Dembogurski, Vania Ramos Sela da Silva, Sueli Oliveira Silva, Denise Brentan da Silva, Marcos Luciano Bruschi, Silvya Stuchi Maria-Engler, Marcia Edilaine Lopes Consolaro
Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. To explore a new therapeutic candidate for cervical cancer, we have evaluated the effects of artepillin C on cellular viability in a comprehensive panel of human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16- and 18-positive) and C33A (HPV-negative) cells compared to a spontaneously immortalized human epithelial cell line (HaCaT)...
June 3, 2018: Anti-cancer Agents in Medicinal Chemistry
Bruna Romana-Souza, Jeanine Salles Dos Santos, Andréa Monte-Alto-Costa
AIMS: In pressure ulcers, the synthesis of reactive oxygen species induced by ischemia and reperfusion leads to chronic inflammation and tissue damage, which impair the closure of these lesions. Caffeic acid phenethyl ester (CAPE), found in propolis, promotes cutaneous wound healing of acute lesions and severe burns. However, the effects of CAPE on wound healing of pressure ulcers have not been investigated. This study investigated the effects of CAPE administration in a murine model of pressure ulcers...
June 1, 2018: Life Sciences
Meda-Romana Simu, Emoke Pall, Teodora Radu, Maria Miclaus, Bogdan Culic, Anca-Stefania Mesaros, Alexandrina Muntean, Gabriela Adriana Filip
In this study we designed a composite biomaterial based on a high viscosity soft propolis extract (70% propolis) and shell clam, with antiseptic and osteoinductive qualities, that can be used in dentistry, orthopedics and other areas where hard tissue regeneration is needed. We assessed it in interaction with stabilized human cells isolated from dental papilla of wisdom teeth (D1MSCs). We performed detailed characterization of the obtained material by Scanning Electronic Microscopy (SEM), X-Ray Diffraction (XRD), Energy Dispersive X-Ray Spectroscopy (EDX), Fourier Transform Infrared Spectroscopy (FTIR) techniques...
June 2018: Tissue & Cell
Piotr M Kuś, Piotr Okińczyc, Martina Jakovljević, Stela Jokić, Igor Jerković
The supercritical CO2 (SC-CO2 ) extraction process of black poplar (Populus nigra L.) buds was optimized (pressure, temperature) based on the yields of major phytochemicals (volatiles and non-volatiles). The optimal settings were 30 MPa/60 °C. Major volatiles determined by GC-MS in the optimized SC-CO2 extract (mg of benzyl salicylate equivalent (BSE) per 100 g of buds) were: pinostrobin chalcone (1574.2), β-eudesmol (640.8), α-eudesmol (581.9), 2-methyl-2-butenyl-p-coumarate (289.9), pentyl-p-coumarate (457...
May 25, 2018: Journal of Pharmaceutical and Biomedical Analysis
İbrahim Kahramanoğlu, Mehmet Aktaş, Şerife Gündüz
Pomegranate fruit consumption has increased rapidly throughout the world, mainly because of its medical and nutritive attributes. Thus, considerable commercial and scientific interest exists in prolonging its postharvest life with non-chemical applications as much as possible to meet the year-round demand for this fruit. The present work aimed to study the effects of black seed oil (0.1% and 0.5%), propolis (0.01% and 0.1%) and fludioxonil (0.06%), with and without modified atmosphere packaging (MAP), on the postharvest quality of pomegranate cv...
2018: PloS One
Shan Xian Lee, Einapak Boontaveeyuwat, Supitchaya Thaiwat, Malcolm Rustin, John McFadden
No abstract text is available yet for this article.
May 30, 2018: Contact Dermatitis
Mariana Leonel Martins, Karla Lorene de França Leite, Edivaldo Ferreira Pacheco-Filho, Adriana Farah de Miranda Pereira, Maria Teresa Villela Romanos, Lucianne Cople Maia, Andréa Fonseca-Gonçalves, Wilton Wilney Nascimento Padilha, Yuri Wanderley Cavalcanti
OBJECTIVE: The efficacy of a red propolis hydro-alcoholic extract (RP) in controlling Streptococcus mutans biofilm colonization was evaluated. The effect of RP on dental demineralization was also investigated. METHODS: Chemical composition was determined by High Performance Liquid Chromatography (HPLC). Minimum Inhibitory and Bactericidal Concentration (MIC and MBC, respectively) were investigated against Streptococcus mutans (ATCC 25175). The cytotoxic potential of 3% RP in oral fibroblasts was observed after 1 and 3 min...
May 23, 2018: Archives of Oral Biology
X J Yuan, Y Y Wang, B Q Shi, Y M Zhao
BACKGROUND/AIM: Propolis has been suggested as a storage medium for avulsed teeth. The aim of this study was to compare the effectiveness of Brazilian propolis with Hank's balanced salt solution and milk in maintaining the viability of human periodontal ligament cells, their osteogenic differentiation potential, and pro-inflammatory cytokine expression. MATERIAL AND METHODS: Cell Counting Kit 8 assays were performed to test human periodontal ligament cell viability in different storage media...
May 27, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Ghazaleh Kheiri, Mahsa Dolatshahi, Farzaneh Rahmani, Nima Rezaei
A myriad of environmental and genetic factors, as well as the physiologic process of aging, contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a focus of interest, as a common gateway for initiation of many of the underlying pathologies of AD. Amyloid beta (Aβ) toxicity, increasing RAGE expression, tau hyperphosphorylation, induction of apoptosis, and deregulated autophagy are among other mechanisms, partly entangled and being explained by activation of mitogen-activated protein kinase (MAPK) and MAPK signaling...
May 28, 2018: Reviews in the Neurosciences
Julianna Karla Santana Andrade, Marina Denadai, George Ricardo Santana Andrade, Cristiane da Cunha Nascimento, Paula Ferreira Barbosa, Monica S Jesus, Narendra Narain
The aim of this study was to obtain dried powders from the brown, green and red varieties of the Brazilian propolis by spray drying, using gum arabic and maltodextrin as encapsulating materials. Propolis microparticles were evaluated for particle size, X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), moisture, water activity, solubility, hygroscopicity, encapsulation efficiency, total phenolic content, flavonoids and antioxidant activity (DPPH, ABTS+ , FRAP, ORAC)...
July 2018: Food Research International
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