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https://www.readbyqxmd.com/read/28641282/health-related-genetic-direct-to-consumer-tests-in-the-german-setting-the-available-offer-and-the-potential-implications-for-a-solidarily-financed-health-care-system
#1
Marika Plöthner, Mike Klora, Daniel Rudolph, Johann-Matthias Graf von der Schulenburg
BACKGROUND: The global genetic direct-to-consumer (DTC) market will reach a volume of USD 230 billion in 2018. The expenditures for this genetic analysis are borne by the customer, whereas consequential costs may arise for a solidarily financed system. In a first step, it is essential to gain an overview of the currently available offer in the German setting. METHODS: In April 2016, we conducted a systematic internet search in the Google search engine. In November 2016, we updated the information of the webpages in terms of country, language, types of health-related tests, additional offer of non-health-related DTC test, information about sensitivity and specificity, certification and accreditation, costs as well as reference to German Act on Genetic Testing...
June 23, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/28609391/promotion-and-marketing-of-bioidentical-hormone-therapy-on-the-internet-a-content-analysis-of-websites
#2
Nese Yuksel, Laetitia Treseng, Bushra Malik, Ubaka Ogbogu
OBJECTIVE: To evaluate the quality of information presented and claims made on websites offering bioidentical hormone therapy (BHT) products or services. METHODS: A quantitative content analysis was completed on 100 websites promoting or offering BHT products or services. Websites were identified through Google search engine from September to October 2013. Search terms included "bioidentical hormone therapy" or "bioidentical progesterone," accompanied by "purchase or buy," "service," or "doctors...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28575964/scaffolds-for-bone-tissue-engineering-state-of-the-art-and-new-perspectives
#3
REVIEW
Livia Roseti, Valentina Parisi, Mauro Petretta, Carola Cavallo, Giovanna Desando, Isabella Bartolotti, Brunella Grigolo
This review is intended to give a state of the art description of scaffold-based strategies utilized in Bone Tissue Engineering. Numerous scaffolds have been tested in the orthopedic field with the aim of improving cell viability, attachment, proliferation and homing, osteogenic differentiation, vascularization, host integration and load bearing. The main traits that characterize a scaffold suitable for bone regeneration concerning its biological requirements, structural features, composition, and types of fabrication are described in detail...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28431546/health-care-public-reporting-utilization-user-clusters-web-trails-and-usage-barriers-on-germany-s-public-reporting-portal-weisse-liste-de
#4
Christoph Pross, Lars-Henrik Averdunk, Josip Stjepanovic, Reinhard Busse, Alexander Geissler
BACKGROUND: Quality of care public reporting provides structural, process and outcome information to facilitate hospital choice and strengthen quality competition. Yet, evidence indicates that patients rarely use this information in their decision-making, due to limited awareness of the data and complex and conflicting information. While there is enthusiasm among policy makers for public reporting, clinicians and researchers doubt its overall impact. Almost no study has analyzed how users behave on public reporting portals, which information they seek out and when they abort their search...
April 21, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28317049/programming-and-runtime-support-to-blaze-fpga-accelerator-deployment-at-datacenter-scale
#5
Muhuan Huang, Di Wu, Cody Hao Yu, Zhenman Fang, Matteo Interlandi, Tyson Condie, Jason Cong
With the end of CPU core scaling due to dark silicon limitations, customized accelerators on FPGAs have gained increased attention in modern datacenters due to their lower power, high performance and energy efficiency. Evidenced by Microsoft's FPGA deployment in its Bing search engine and Intel's 16.7 billion acquisition of Altera, integrating FPGAs into datacenters is considered one of the most promising approaches to sustain future datacenter growth. However, it is quite challenging for existing big data computing systems-like Apache Spark and Hadoop-to access the performance and energy benefits of FPGA accelerators...
October 2016: Proceedings of the ... ACM Symposium on Cloud Computing [electronic Resource]: SOCC ... ... SoCC (Conference)
https://www.readbyqxmd.com/read/28314988/polymeric-micelles-as-mighty-nanocarriers-for-cancer-gene-therapy-a-review
#6
REVIEW
Mahsa Yousefpour Marzbali, Ahmad Yari Khosroushahi
PURPOSE: Gene therapy has shown extensive potential to treat human diseases occurring from the defection of genes like various types of cancers. The cationic polymers, as non-viral gene carriers, offer the ability to engineer carrier systems having customized features that can be adapted to suit any system. Upon polymeric micelle systems' core-shell structure, micelles can create the capacity to load genes/gene-drugs into the different micelle compartments, respectively. METHODS: The search will be managed in Pubmed, Medline, Cochrane library, Embase and Proquest for articles related to polymeric micelle-based gene delivery in order to cancer gene therapy using the accommodative search terms...
April 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28231323/even-good-bots-fight-the-case-of-wikipedia
#7
Milena Tsvetkova, Ruth García-Gavilanes, Luciano Floridi, Taha Yasseri
In recent years, there has been a huge increase in the number of bots online, varying from Web crawlers for search engines, to chatbots for online customer service, spambots on social media, and content-editing bots in online collaboration communities. The online world has turned into an ecosystem of bots. However, our knowledge of how these automated agents are interacting with each other is rather poor. Bots are predictable automatons that do not have the capacity for emotions, meaning-making, creativity, and sociality and it is hence natural to expect interactions between bots to be relatively predictable and uneventful...
2017: PloS One
https://www.readbyqxmd.com/read/28145767/examining-guidelines-for-school-based-breakfast-programs-in-canada-a-systematic-review-of-the-grey-literature
#8
Katelyn M Godin, Sharon I Kirkpatrick, Rhona M Hanning, Jackie Stapleton, Scott T Leatherdale
School breakfast programs are widespread and serve varying objectives regarding youth health promotion. Evidence-based guidelines for breakfast programs may be important in maximizing their effectiveness related to student outcomes, yet it is unclear what is available in Canada. A systematic review was conducted to identify and compare Canadian guidelines related to breakfast programs. Data sources included grey literature databases, customized search engines, targeted websites, and content expert consultations...
February 1, 2017: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/27997674/validity-of-activity-monitors-in-wheelchair-users-a-systematic-review
#9
KaLai Tsang, Shivayogi V Hiremath, Theresa M Crytzer, Brad E Dicianno, Dan Ding
Assessing physical activity (PA) in manual wheelchair users (MWUs) is challenging because of their different movement patterns in comparison to the ambulatory population. The aim of this review was to investigate the validity of portable monitors in quantifying PA in MWUs. A systematic literature search was performed. The data source was full reports of validation and evaluation studies in peer-reviewed journals and conference proceedings. Eligible articles between January 1, 1999, and September 18, 2015, were identified in three databases: PubMed, Institute of Electrical and Electronics Engineers, and Scopus...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27959968/enhanced-visualization-of-subtle-outer-retinal-pathology-by-en-face-optical-coherence-tomography-and-correlation-with-multi-modal-imaging
#10
Danuta M Sampson, David Alonso-Caneiro, Avenell L Chew, Tina Lamey, Terri McLaren, John De Roach, Fred K Chen
PURPOSE: To present en face optical coherence tomography (OCT) images generated by graph-search theory algorithm-based custom software and examine correlation with other imaging modalities. METHODS: En face OCT images derived from high density OCT volumetric scans of 3 healthy subjects and 4 patients using a custom algorithm (graph-search theory) and commercial software (Heidelberg Eye Explorer software (Heidelberg Engineering)) were compared and correlated with near infrared reflectance, fundus autofluorescence, adaptive optics flood-illumination ophthalmoscopy (AO-FIO) and microperimetry...
2016: PloS One
https://www.readbyqxmd.com/read/27874913/metal-on-metal-total-hip-arthroplasty-quality-of-online-patient-information
#11
Geoff Crozier-Shaw, Joseph M Queally, John F Quinlan
Metal-on-metal total hip arthroplasty (THA) has generated much attention in the media because of early failure of certain implant systems. This study assessed the quality, accuracy, and readability of online information on metal-on-metal THA. The search terms "metal-on-metal hip replacement" and "metal hip replacement" were entered into the 3 most popular search engines. Information quality was assessed with the DISCERN score and a specific metal-on-metal THA content score. Accuracy of information was assessed with a customized score...
March 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/27773706/synthesis-biological-characterization-and-evaluation-of-molecular-mechanisms-of-novel-copper-complexes-as-anticancer-agents
#12
Ceyda Acilan, Buse Cevatemre, Zelal Adiguzel, Didem Karakas, Engin Ulukaya, Nádia Ribeiro, Isabel Correia, João Costa Pessoa
BACKGROUND: To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based compounds. Here, three Cu(II)-complexes, Cu(Sal-Gly)(phen), Cu(Sal-Gly)(pheamine), Cu(Sal-Gly)(phepoxy) are characterized for their interaction with DNA, cytotoxicity and mechanism of action. METHODS: The binding ability of the complexes to Calf-Thymus DNA was evaluated by competition fluorescence studies with thiazole-orange, UV-Vis and circular dichroism spectroscopic titrations...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27692980/-automated-grouping-of-terms-associated-to-cardiac-valve-fibrosis-in-meddra
#13
Hadyl Asfari, Julien Souvignet, Agnès Lillo-Le Louët, Béatrice Trombert, Marie-Christine Jaulent, Cédric Bousquet
AIM: To propose an alternative approach for building custom groupings of terms that complements the usual approach based on both hierarchical method (selection of reference groupings in medical dictionary for regulatory activities [MedDRA]) and/or textual method (string search), for case reports extraction from a pharmacovigilance database in response to a safety problem. Here we take cardiac valve fibrosis as an example. METHODS: The list of terms obtained by an automated approach, based on querying ontology of adverse drug reactions (OntoADR), a knowledge base defining MedDRA terms through relationships with systematized nomenclature of medicine-clinical terms (SNOMED CT) concepts, was compared with the reference list consisting of 53 preferred terms obtained by hierarchical and textual method...
July 21, 2016: Thérapie
https://www.readbyqxmd.com/read/27500145/high-intensity-focused-ultrasound-hifu-applied-to-hepato-bilio-pancreatic-and-the-digestive-system-current-state-of-the-art-and-future-perspectives
#14
REVIEW
Michele Diana, Luigi Schiraldi, Yu-Yin Liu, Riccardo Memeo, Didier Mutter, Patrick Pessaux, Jacques Marescaux
BACKGROUND: High intensity focused ultrasound (HIFU) is emerging as a valid minimally-invasive image-guided treatment of malignancies. We aimed to review to current state of the art of HIFU therapy applied to the digestive system and discuss some promising avenues of the technology. METHODS: Pertinent studies were identified through PubMed and Embase search engines using the following keywords, combined in different ways: HIFU, esophagus, stomach, liver, pancreas, gallbladder, colon, rectum, and cancer...
August 2016: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/27265049/biomedical-search-engine-framework-lightweight-and-customized-implementation-of-domain-specific-biomedical-search-engines
#15
Alberto G Jácome, Florentino Fdez-Riverola, Anália Lourenço
BACKGROUND AND OBJECTIVES: Text mining and semantic analysis approaches can be applied to the construction of biomedical domain-specific search engines and provide an attractive alternative to create personalized and enhanced search experiences. Therefore, this work introduces the new open-source BIOMedical Search Engine Framework for the fast and lightweight development of domain-specific search engines. The rationale behind this framework is to incorporate core features typically available in search engine frameworks with flexible and extensible technologies to retrieve biomedical documents, annotate meaningful domain concepts, and develop highly customized Web search interfaces...
July 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27231314/pyquant-a-versatile-framework-for-analysis-of-quantitative-mass-spectrometry-data
#16
Christopher J Mitchell, Min-Sik Kim, Chan Hyun Na, Akhilesh Pandey
Quantitative mass spectrometry data necessitates an analytical pipeline that captures the accuracy and comprehensiveness of the experiments. Currently, data analysis is often coupled to specific software packages, which restricts the analysis to a given workflow and precludes a more thorough characterization of the data by other complementary tools. To address this, we have developed PyQuant, a cross-platform mass spectrometry data quantification application that is compatible with existing frameworks and can be used as a stand-alone quantification tool...
August 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27225868/jumpg-an-integrative-proteogenomics-pipeline-identifying-unannotated-proteins-in-human-brain-and-cancer-cells
#17
Yuxin Li, Xusheng Wang, Ji-Hoon Cho, Timothy I Shaw, Zhiping Wu, Bing Bai, Hong Wang, Suiping Zhou, Thomas G Beach, Gang Wu, Jinghui Zhang, Junmin Peng
Proteogenomics is an emerging approach to improve gene annotation and interpretation of proteomics data. Here we present JUMPg, an integrative proteogenomics pipeline including customized database construction, tag-based database search, peptide-spectrum match filtering, and data visualization. JUMPg creates multiple databases of DNA polymorphisms, mutations, splice junctions, partially trypticity, as well as protein fragments translated from the whole transcriptome in all six frames upon RNA-seq de novo assembly...
July 1, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/26814377/green-hospital-and-climate-change-their-interrelationship-and-the-way-forward
#18
REVIEW
Vardeep Singh Dhillon, Dilpreet Kaur
Climate change is a reality, and the modern healthcare sector not just contributes towards this grave phenomenon but is itself being affected by it. The present review was thus conducted to understand the meaning of 'Green Hospital', to identify the many ways in which health sector is contributing towards climate change, to explore possibilities for countering this grave trend and last of all to look for institutions that are pioneering change. Data for the review was extracted from multiple online sources using the Google search engine...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26629955/autodockfr-advances-in-protein-ligand-docking-with-explicitly-specified-binding-site-flexibility
#19
Pradeep Anand Ravindranath, Stefano Forli, David S Goodsell, Arthur J Olson, Michel F Sanner
Automated docking of drug-like molecules into receptors is an essential tool in structure-based drug design. While modeling receptor flexibility is important for correctly predicting ligand binding, it still remains challenging. This work focuses on an approach in which receptor flexibility is modeled by explicitly specifying a set of receptor side-chains a-priori. The challenges of this approach include the: 1) exponential growth of the search space, demanding more efficient search methods; and 2) increased number of false positives, calling for scoring functions tailored for flexible receptor docking...
December 2015: PLoS Computational Biology
https://www.readbyqxmd.com/read/26605116/support-patient-search-on-pathology-reports-with-interactive-online-learning-based-data-extraction
#20
Shuai Zheng, James J Lu, Christina Appin, Daniel Brat, Fusheng Wang
BACKGROUND: Structural reporting enables semantic understanding and prompt retrieval of clinical findings about patients. While synoptic pathology reporting provides templates for data entries, information in pathology reports remains primarily in narrative free text form. Extracting data of interest from narrative pathology reports could significantly improve the representation of the information and enable complex structured queries. However, manual extraction is tedious and error-prone, and automated tools are often constructed with a fixed training dataset and not easily adaptable...
2015: Journal of Pathology Informatics
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