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https://www.readbyqxmd.com/read/29044940/low-intrapatient-variability-of-histomorphological-findings-in-periprosthetic-tissues-from-revised-metal-ceramic-on-polyethylene-joint-arthroplasties
#1
Jana Vaculova, Jiri Gallo, Pavel Hurnik, Oldrich Motyka, Stuart B Goodman, Jana Dvorackova
The type of tissue response to implant by-products can be determined by examination of periprosthetic tissues. However, little is known about the most suitable location for tissue sampling. The main goal of this study was to evaluate the extent of variability in tissue response in relation to location of tissue sampling, implant fixation, age and sex in total joint arthroplasties with metal-on-polyethylene or ceramic-on-polyethylene bearing pairs. We processed 236 histology slides from 21 patients and focused on the association between the location of tissue samples and histological features...
October 16, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29044825/pattern-of-bleeding-in-a-large-prospective-cohort-of-haemophilia-a-patients-a-three-year-follow-up-of-the-ahead-advate-in-haemophilia-a-outcome-database-study
#2
K Khair, M G Mazzucconi, R Parra, E Santagostino, D A Tsakiris, C Hermans, J Oldenburg, G Spotts, K Steinitz-Trost, A Gringeri
INTRODUCTION: Outcome data on treatment of patients with haemophilia A spanning several years of real-world evidence collection are currently very limited. AIM AND METHODS: The global prospective long-term Advate(®) Haemophilia A Outcome Database (AHEAD) cohort study collects real-world data from patients with severe and moderate haemophilia. We report an interim data read-out after three years of observation. RESULTS: A total of 522 patients were enrolled from 21 countries: 334 completed year 1 follow-up, 238 completed year 2 and 136 completed year 3, with an overall follow-up of 811 patient-years...
October 17, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29044458/patient-reported-quality-of-life-outcomes-after-de-escalated-chemoradiation-for-human-papillomavirus-positive-oropharyngeal-carcinoma-findings-from-a-phase-2-trial
#3
John V Hegde, Narek Shaverdian, Megan E Daly, Carol Felix, Deborah L Wong, Michael H Rosove, Jordan H Garst, Pin-Chieh Wang, Darlene Veruttipong, Shyam Rao, Ruben C Fragoso, Jonathan W Riess, Michael L Steinberg, Allen M Chen
BACKGROUND: The current study represents a subset analysis of quality-of-life (QOL) outcomes among patients treated on a phase 2 trial of de-escalated chemoradiation for human papillomavirus (HPV)-associated oropharyngeal cancer. METHODS: Eligibility included newly diagnosed, (American Joint Committee on Cancer, 7th edition) stage III or IV oropharyngeal squamous cell carcinoma, p16 positivity, age ≥ 18 years, and a Zubrod performance status of 0 to 1. Treatment was induction paclitaxel at a dose of 175 mg/m(2) and carboplatin at an area under the curve of 6 for 2 cycles followed by response-adapted, dose-reduced radiation of 54 Gy or 60 Gy with weekly concurrent paclitaxel at a dose of 30 mg/m(2) ...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29043949/arthroscopic-surgery-for-knee-osteoarthritis-impact-of-health-technology-assessment-in-germany
#4
Naomi Fujita-Rohwerder, Alric Rüther, Stefan Sauerland
OBJECTIVES: This study aims to describe how a negative reimbursement decision-based on the health technology assessment (HTA) report of a nondrug intervention-affects healthcare providers in Germany. METHODS: Knee arthroscopy was chosen as an example, because as of April 2016 this procedure is no longer reimbursed for osteoarthritis, but is still covered for other indications, including meniscal lesions. The exclusion followed an HTA report prepared by the Institute for Quality and Efficiency in Health Care (IQWiG)...
October 18, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29043580/a-comprehensive-assessment-of-accurate-lymph-node-staging-and-preoperative-detection-in-resected-pancreatic-cancer
#5
Toshiro Masuda, Amanda M Dann, Irmina A Elliott, Hideo Baba, Stephen Kim, Alireza Sedarat, V Raman Muthusamy, Mark D Girgis, O Joe Hines, Howard A Reber, Timothy R Donahue
BACKGROUND: The current (seventh edition) American Joint Commission on Cancer (AJCC) Staging System for pancreatic ductal adenocarcinoma (PDAC) dichotomizes pathologic lymph node (LN) involvement into absence (pN0) or presence (pN1) of disease. The recently announced eighth edition also includes stratification on the number of positive nodes. Furthermore, LNs detected on preoperative imaging (CT, MRI, or endoscopic ultrasound-EUS) are considered to be pathologically involved in other gastrointestinal cancers...
October 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29043096/sex-determination-using-humeral-dimensions-in-a-sample-from-kwazulu-natal-an-osteometric-study
#6
Oluwatosin Olalekan Ogedengbe, Sunday Adelaja Ajayi, Omobola Aderibigbe Komolafe, Aung Khaing Zaw, Edwin Coleridge Stephen Naidu, Onyemaechi Okpara Azu
The morphological characteristics of the humeral bone has been investigated in recent times with studies showing varying degrees of sexual dimorphism. Osteologists and forensic scientists have shown that sex determination methods based on skeletal measurements are population specific, and these population-specific variations are present in many body dimensions. The present study aims to establish sex identification using osteometric standards for the humerus in a contemporary KwaZulu-Natal population. A total of 11 parameters were measured in a sample of n=211 humeri (males, 113; females, 98) from the osteological collection in the Discipline of Clinical Anatomy, Nelson R...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042844/designing-a-care-pathway-model-a-case-study-of-the-outpatient-total-hip-arthroplasty-care-pathway
#7
Robin I Oosterholt, Lianne Wl Simonse, Stella U Boess, Stephan Bw Vehmeijer
INTRODUCTION: Although the clinical attributes of total hip arthroplasty (THA) care pathways have been thoroughly researched, a detailed understanding of the equally important organisational attributes is still lacking. The aim of this article is to contribute with a model of the outpatient THA care pathway that depicts how the care team should be organised to enable patient discharge on the day of surgery. THEORY: The outpatient THA care pathway enables patients to be discharged on the day of surgery, shortening the length of stay and intensifying the provision and organisation of care...
March 9, 2017: International Journal of Integrated Care
https://www.readbyqxmd.com/read/29042619/diffusion-tensor-image-features-predict-idh-genotype-in-newly-diagnosed-who-grade-ii-iii-gliomas
#8
Paul Eichinger, Esther Alberts, Claire Delbridge, Stefano Trebeschi, Alexander Valentinitsch, Stefanie Bette, Thomas Huber, Jens Gempt, Bernhard Meyer, Juergen Schlegel, Claus Zimmer, Jan S Kirschke, Bjoern H Menze, Benedikt Wiestler
We hypothesized that machine learning analysis based on texture information from the preoperative MRI can predict IDH mutational status in newly diagnosed WHO grade II and III gliomas. This retrospective study included in total 79 consecutive patients with a newly diagnosed WHO grade II or III glioma. Local binary pattern texture features were generated from preoperative B0 and fractional anisotropy (FA) diffusion tensor imaging. Using a training set of 59 patients, a single hidden layer neural network was then trained on the texture features to predict IDH status...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042134/the-use-of-dynamic-radiographs-in-trapeziometacarpal-joint-arthrodesis-for-accurate-range-of-motion-evaluation
#9
Brian Dormitorio, Yasunori Hattori, Kiminori Yukata, Sotetsu Sakamoto, Kazuteru Doi
BACKGROUND: Increased motion at the scaphotrapeziotrapezoidal (STT) joint and compensatory hypermobility of metacarpophalangeal (MP) joint contribute to the total abduction and adduction motion of the thumb after trapeziometacarpal (TM) joint arthrodesis. However, there were no detailed studies to evaluate the contribution of motion of each joint towards total thumb mobility. METHODS: We conducted a comparative study on thumb joint motion in 56 hands who underwent TM joint arthrodesis against that of 56 hands in normal subjects...
October 14, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29041949/incretins-in-patients-with-rheumatoid-arthritis
#10
Beatriz Tejera-Segura, Raquel López-Mejías, María Jesús Domínguez-Luis, Antonia M de Vera-González, Alejandra González-Delgado, Begoña Ubilla, José M Olmos, José L Hernández, Miguel A González-Gay, Iván Ferraz-Amaro
BACKGROUND: The precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. In the present study, we determined whether the incretin-insulin axis and incretin effect are disrupted in patients with RA and if they are related to the IR found in these patients. METHODS: We conducted a cross-sectional study that encompassed 361 subjects without diabetes, 151 patients with RA, and 210 sex-matched control subjects...
October 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29041819/subjective-health-complaints-and-illness-perception-amongst-adults-with-joint-hypermobility-syndrome-ehlers-danlos-syndrome-hypermobilitytype-a-cross-sectional-study
#11
Lena Hope, Birgit Juul-Kristensen, Helene Løvaas, Camilla Løvvik, Silje Maeland
OBJECTIVE: To investigate the prevalence and severity of subjective health complaints and describe illness perception in a population of Joint Hypermobility Syndrome or Ehlers-Danlos Syndrome-Hypermobile Type. METHOD: This study was a postal survey with a questionnaire battery on demographic data, subjective health complaints inventory, and illness perception. A total of 110 individuals diagnosed with Joint Hypermobility Syndrome or Ehlers-Danlos Syndrome-Hypermobile Type from two specialized hospitals in Norway were offered participation...
October 17, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29041711/high-order-modulation-on-a-single-discrete-eigenvalue-for-optical-communications-based-on-nonlinear-fourier-transform
#12
Tao Gui, Chao Lu, Alan Pak Tao Lau, P K A Wai
In this paper, we experimentally investigate high-order modulation over a single discrete eigenvalue under the nonlinear Fourier transform (NFT) framework and exploit all degrees of freedom for encoding information. For a fixed eigenvalue, we compare different 4 bit/symbol modulation formats on the spectral amplitude and show that a 2-ring 16-APSK constellation achieves optimal performance. We then study joint spectral phase, spectral magnitude and eigenvalue modulation and found that while modulation on the real part of the eigenvalue induces pulse timing drift and leads to neighboring pulse interactions and nonlinear inter-symbol interference (ISI), it is more bandwidth efficient than modulation on the imaginary part of the eigenvalue in practical settings...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29041089/led-power-consumption-in-joint-illumination-and-communication-system
#13
Xiong Deng, Yan Wu, A M Khalid, Xi Long, Jean-Paul M G Linnartz
This paper addresses the power penalty in an illumination LED caused by visible light communication (VLC). This study models the extra power consumption of the LED by taking into account the convex relation between the dissipated electrical power versus the LED current on one hand and the concave relation between the output luminous flux versus the current on the other hand. The ratio of the output luminous flux to input electrical power, which is known the LED luminous efficacy, is analyzed considering various recombination mechanisms and their dependency on current and temperature...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29040335/is-patient-empowerment-the-key-to-promote-adherence-a-systematic-review-of-the-relationship-between-self-efficacy-health-locus-of-control-and-medication-adherence
#14
Lilla Náfrádi, Kent Nakamoto, Peter J Schulz
BACKGROUND: Current health policies emphasize the need for an equitable doctor-patient relationship, and this requires a certain level of patient empowerment. However, a systematic review of the empirical evidence on how empowerment affects medication adherence-the extent to which patients follow the physician's prescription of medication intake-is still missing. The goal of this systematic review is to sum up current state-of-the-art knowledge concerning the relationship between patient empowerment and medication adherence across medical conditions...
2017: PloS One
https://www.readbyqxmd.com/read/29040274/a-quadratically-regularized-functional-canonical-correlation-analysis-for-identifying-the-global-structure-of-pleiotropy-with-ngs-data
#15
Nan Lin, Yun Zhu, Ruzong Fan, Momiao Xiong
Investigating the pleiotropic effects of genetic variants can increase statistical power, provide important information to achieve deep understanding of the complex genetic structures of disease, and offer powerful tools for designing effective treatments with fewer side effects. However, the current multiple phenotype association analysis paradigm lacks breadth (number of phenotypes and genetic variants jointly analyzed at the same time) and depth (hierarchical structure of phenotype and genotypes). A key issue for high dimensional pleiotropic analysis is to effectively extract informative internal representation and features from high dimensional genotype and phenotype data...
October 17, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29040144/surgical-treatment-of-dentofacial-deformities-caused-by-juvenile-idiopathic-arthritis
#16
Patricia Stoor, Zlatan Hodzic, Sirpa Arte
The purpose of our retrospective study was to evaluate the results of orthognathic treatment, distraction osteogenesis, and/or prosthetic reconstruction of the temporomandibular joints in patients with juvenile idiopathic arthritis (JIA).Twelve patients with severely affected temporomandibular joints (TMJs) and reduced ramus height were treated with mandibular advancement with orthognathic surgery (11) and additional bilateral or unilateral mandibular ramus distraction (3) or additional bilateral or unilateral prosthetic reconstruction of the TMJ (3)...
October 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29040128/single-dose-preoperative-vitamin-d-supplementation-decreases-infection-in-a-mouse-model-of-periprosthetic-joint-infection
#17
Vishal Hegde, Erik M Dworsky, Alexandra I Stavrakis, Amanda H Loftin, Stephen D Zoller, Howard Y Park, Sherif Richman, Daniel Johansen, Yan Hu, Julie A Taylor, Christopher D Hamad, Rene F Chun, Weixian Xi, John S Adams, Nicholas M Bernthal
BACKGROUND: Despite recent advances, infection remains the most common etiology of arthroplasty failure. Recent work suggests that 25-hydroxyvitamin D (25D) deficiency correlates with the frequency of periprosthetic joint infection (PJI). We endeavored to examine whether 25D3 deficiency leads to increased bacterial burden in vivo in an established mouse model of PJI and, if so, whether this effect can be reversed by preoperative 25D3 supplementation. METHODS: Mice (lys-EGFP) possessing fluorescent neutrophils were fed a vitamin D3-sufficient (n = 20) or deficient (n = 40) diet for 6 weeks...
October 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29039969/clinical-outcomes-and-failure-rates-of-osteochondral-allograft-transplantation-in-the-knee-a-systematic-review
#18
Filippo Familiari, Mark E Cinque, Jorge Chahla, Jonathan A Godin, Morten Lykke Olesen, Gilbert Moatshe, Robert F LaPrade
BACKGROUND: Cartilage lesions are a significant cause of morbidity and impaired knee function; however, cartilage repair procedures have failed to reproduce native cartilage to date. Thus, osteochondral allograft (OCA) transplantation represents a 1-step procedure to repair large chondral defects without the donor site morbidity of osteochondral autograft transplantation. PURPOSE: To perform a systematic review of clinical outcomes and failure rates after OCA transplantation in the knee at a minimum mean 2 years' follow-up...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29039723/glenohumeral-internal-rotation-deficit-in-table-tennis-players
#19
Danilo Harudy Kamonseki, Luísa Cedin, Fernanda Assis Paes Habechian, Guigliano Franco Piccolomo, Paula Rezende Camargo
Table tennis requires rapid and extreme movements that may result in shoulder adaptations, such as glenohumeral internal rotation deficit, which is a risk factor for several injuries. This study compared range of motion of internal and external rotation and total rotation motion of glenohumeral joint between dominant and non-dominant shoulders of table tennis players. This is a cross-sectional observational study. Twenty healthy male table tennis players that were enrolled in an official table tennis league took part in this study (mean age: 22...
October 17, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29039259/single-camera-visual-odometry-to-track-a-surgical-x-ray-c-arm-base
#20
Hooman Esfandiari, Derek Lichti, Carolyn Anglin
This study provides a framework for a single-camera odometry system for localizing a surgical C-arm base. An application-specific monocular visual odometry system (a downward-looking consumer-grade camera rigidly attached to the C-arm base) is proposed in this research. The cumulative dead-reckoning estimation of the base is extracted based on frame-to-frame homography estimation. Optical-flow results are utilized to feed the odometry. Online positional and orientation parameters are then reported. Positional accuracy of better than 2% (of the total traveled distance) for most of the cases and 4% for all the cases studied and angular accuracy of better than 2% (of absolute cumulative changes in orientation) were achieved with this method...
October 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
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