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https://www.readbyqxmd.com/read/29683034/inflammatory-biomarker-profiling-in-total-joint-arthroplasty-and-its-relevance-to-circulating-levels-of-lubricin-a-novel-proteoglycan
#1
Kevin Galicia, Chase Thorson, Andrew Banos, Matthew Rondina, William Hopkinson, Debra Hoppensteadt, Jawed Fareed
Lubricin, also known as proteoglycan 4, acts as an antiadhesive and boundary lubricant to prevent cartilage damage in healthy joints. Following injury, a decrease in synovial fluid (SF) lubricin may lead to secondary osteoarthritis (OA). Inflammatory biomarkers, such as IL-1β and TNF-α, are also implicated in the pathophysiology of OA. Interestingly, they have been shown to suppress the expression and secretion of lubricin in SF. This study aims to compare circulating levels of inflammatory biomarkers and lubricin between total joint arthroplasty (TJA) patients and healthy individuals...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29683031/32-mm-ceramic-on-ceramic-total-hip-arthroplasty-versus-28-mm-ceramic-bearings-5-to-15-year-follow-up-study
#2
Yoshitoshi Higuchi, Taisuke Seki, Yukiharu Hasegawa, Yasuhiko Takegami, Daigo Morita, Naoki Ishiguro
INTRODUCTION: This study aimed to compare the clinical and radiographic results of 28-mm ceramic-on-ceramic (CoC) total hip arthroplasty (THA) to those of 32-mm CoC during a 5- to 15-year follow-up period. METHODS: 107 joints (95 women and 6 men) underwent 28-mm CoC, and 60 (49 women and 7 men) underwent 32-mm CoC. The average patient age at the time of surgery was 56.1 and 55.7 years in the 28-mm and 32-mm CoC groups, respectively. Clinical and radiologic measurements of all patients were analysed...
April 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29682414/three-dimensional-architecture-of-the-whole-human-soleus-muscle-in-vivo
#3
Bart Bolsterlee, Taija Finni, Arkiev D'Souza, Junya Eguchi, Elizabeth C Clarke, Robert D Herbert
Background: Most data on the architecture of the human soleus muscle have been obtained from cadaveric dissection or two-dimensional ultrasound imaging. We present the first comprehensive, quantitative study on the three-dimensional anatomy of the human soleus muscle in vivo using diffusion tensor imaging (DTI) techniques. Methods: We report three-dimensional fascicle lengths, pennation angles, fascicle curvatures, physiological cross-sectional areas and volumes in four compartments of the soleus at ankle joint angles of 69 ± 12° (plantarflexion, short muscle length; average ± SD across subjects) and 108 ± 7° (dorsiflexion, long muscle length) of six healthy young adults...
2018: PeerJ
https://www.readbyqxmd.com/read/29682284/staphylococcal-enterotoxin-c2-promotes-osteogenesis-of-mesenchymal-stem-cells-and-accelerates-fracture-healing
#4
T Wu, J Zhang, B Wang, Y Sun, Y Liu, G Li
Objectives: As one of the heat-stable enterotoxins, Staphylococcal enterotoxin C2 (SEC2) is synthesized by Staphylococcus aureus , which has been proved to inhibit the growth of tumour cells, and is used as an antitumour agent in cancer immunotherapy. Although SEC2 has been reported to promote osteogenic differentiation of human mesenchymal stem cells (MSCs), the in vivo function of SCE2 in animal model remains elusive. The aim of this study was to further elucidate the in vivo effect of SCE2 on fracture healing...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29682282/a-pilot-hole-does-not-reduce-the-strains-or-risk-of-fracture-to-the-lateral-cortex-during-and-following-a-medial-opening-wedge-high-tibial-osteotomy-in-cadaveric-specimens
#5
K Bujnowski, A Getgood, K Leitch, J Farr, C Dunning, T A Burkhart
Aim: It has been suggested that the use of a pilot-hole may reduce the risk of fracture to the lateral cortex. Therefore the purpose of this study was to determine the effect of a pilot hole on the strains and occurrence of fractures at the lateral cortex during the opening of a high tibial osteotomy (HTO) and post-surgery loading. Materials and Methods: A total of 14 cadaveric tibias were randomized to either a pilot hole (n = 7) or a no-hole (n = 7) condition...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29681858/aqueous-extract-of-black-maca-prevents-metabolism-disorder-via-regulating-the-glycolysis-gluconeogenesis-tca-cycle-and-ppar%C3%AE-signaling-activation-in-golden-hamsters-fed-a-high-fat-high-fructose-diet
#6
Wenting Wan, Hongxiang Li, Jiamei Xiang, Fan Yi, Lijia Xu, Baoping Jiang, Peigen Xiao
Maca ( Lepidium meyenii Walpers) has been used as a dietary supplement and ethnomedicine for centuries. Recently, maca has become a high profile functional food worldwide because of its multiple biological activities. This study is the first explorative research to investigate the prevention and amelioration capacity of the aqueous extract of black maca (AEM) on high-fat, high-fructose diet (HFD)-induced metabolism disorder in golden hamsters and to identify the potential mechanisms involved in these effects...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681494/improvement-in-depression-and-physical-health-following-total-joint-arthroplasty
#7
Belal A Tarakji, Aaron T Wynkoop, Ajay K Srivastava, Erin G O'Connor, Theresa S Atkinson
BACKGROUND: Depression is a common co-morbid condition seen in arthroplasty patients. Pain and depression have been understood to influence one another, which may explain why this patient group experiences higher rates of depression than the general population. Arthroplasty can relieve pain and improve function, which may thereby initiate an improvement in the patient's depressive symptoms. METHODS: This retrospective study examined physical and mental domain outcomes of Short Form-36 health-related quality of life questionnaire among 146 patients who underwent primary hip or knee arthroplasty for osteoarthritis at a single institution during 2001-2004...
March 27, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29680905/intraoperative-soft-tissue-balance-using-novel-medial-preserving-gap-technique-in-posterior-stabilized-total-knee-arthroplasty-comparison-to-measured-resection-technique
#8
Kanto Nagai, Hirotsugu Muratsu, Yutaro Kanda, Masanori Tsubosaka, Tomoyuki Kamenaga, Hidetoshi Miya, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto
PURPOSE: To investigate intraoperative soft tissue balance with femoral component trial in place using a novel medial preserving gap technique, focusing on medial compartment stability and allowing lateral physiological laxity, with compared with using a measured resection technique in posterior-stabilized (PS) total knee arthroplasty (TKA). METHODS: Primary PS TKA, using either medial preserving gap technique (n = 127) or measured resection technique (n = 148), was performed in 275 subjects with varus knee osteoarthritis...
April 21, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29680845/a-comparison-of-the-effects-of-methylprednisolone-acetate-sodium-hyaluronate-and-tenoxicam-in-the-treatment-of-non-reducing-disc-displacement-of-the-temporomandibular-joint
#9
G-Y Yapici-Yavuz, G Simsek-Kaya, H Ogul
BACKGROUND: This clinical study aimed to radiologically and clinically compare the effect of intra-articular injection of methylprednisolone, sodium hyaluronate or tenoxicam following arthrocentesis with that of arthrocentesis alone in patients with non-reducing disc displacement. MATERIAL AND METHODS: A total of 44 patients radiographically diagnosed with non-reducing disc displacement of the temporomandibular joint (TMJ) were randomly divided into four treatment groups, as follows: Group 1, arthrocentesis alone; Group 2, arthrocentesis plus methylprednisolone acetate; Group 3, arthrocentesis plus sodium hyaluronate; Group 4, arthrocentesis plus tenoxicam...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29680840/is-arthrocentesis-of-temporomandibular-joint-with-corticosteroids-beneficial-a-systematic-review
#10
A Davoudi, H Khaki, I Mohammadi, M Daneshmand, A Tamizifar, M Bigdelou, F Ansaripoor
BACKGROUND: Temporomandibular disorders (TMDs) are musculoskeletal conditions that can inhibit the normal function of temporomandibular joints (TMJs) and affect the patient's quality of life, negatively. Arthrocentesis (AC) is a minimally invasive surgical procedure used for treating TMDs. The aim of present paper is to evaluate the advantages of administrating corticosteroid (CS) during AC by reviewing high quality released articles. MATERIAL AND METHODS: Searching on Cochrane Library, Web of Science, Google Scholar, PubMed, ProQuest, and Scopus databases were performed with focusing on proper key words...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29680417/gender-specific-independent-and-combined-dose-response-association-of-napping-and-night-sleep-duration-with-type-2-diabetes-mellitus-in-rural-chinese-adults-the-ruraldiab-study
#11
Ruihua Liu, Yuqian Li, Zhenxing Mao, Xiaotian Liu, Haiqing Zhang, Kaili Yang, Honglei Zhang, Runqi Tu, Xinling Qian, Jingjing Jiang, Ronghai Bie, Chongjian Wang
OBJECTIVE: The aim of this study was to explore the independent and combined dose-response association of napping and night sleep duration with type 2 diabetes mellitus (T2DM) among different genders in the rural Chinese population. METHODS: For this research, a total of 19,257 participants were enrolled in the Rural Diabetes, Obesity and Lifestyle (RuralDiab) study. Napping and night sleep duration were assessed using the Pittsburgh Sleep Quality Index (PSQI). Restricted cubic splines and logistic regression were used to estimate the relationship between napping and night sleep duration with T2DM...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680162/baseline-patient-reported-outcomes-are-more-consistent-predictors-of-long-term-functional-disability-than-laboratory-imaging-or-joint-count-data-in-patients-with-early-inflammatory-arthritis-a-systematic-review
#12
REVIEW
James M Gwinnutt, Charlotte A Sharp, Deborah P M Symmons, Mark Lunt, Suzanne M M Verstappen
OBJECTIVE: To assess baseline predictors of long-term functional disability in patients with inflammatory arthritis (IA). METHODS: We conducted a systematic review of the literature from 1990 to 2017 using MEDLINE and EMBASE. Studies were included if (i) they were prospective observational studies, (ii) all patients had IA with symptom duration ≤2 years at baseline, (iii) follow-up was at least 5 years, and (iv) baseline predictors of HAQ score at long-term follow-up (i...
March 15, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29679723/comparison-of-hook-plate-with-versus-without-double-tunnel-coracoclavicular-ligament-reconstruction-for-repair-of-acute-acromioclavicular-joint-dislocations-a-prospective-randomized-controlled-clinical-trial
#13
Jian Yin, Zhaoyang Yin, Ge Gong, Chao Zhu, Chao Sun, Xinhui Liu
PURPOSE: This study was designed to compare the surgical outcomes of a hook plate with double-tunnel coracoclavicular (CC) ligament reconstruction by conjoined tendon transfer versus single hook plate surgery for the repair of acute type of Rockwood type III and V acromioclavicular (AC) joint dislocations. METHODS: The study cohort included 62 patients with acute (within 6 weeks after trauma) Rockwood type III and V AC joint dislocations who underwent surgery from February 2012 to September 2015...
April 18, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29679330/in-vitro-model-of-macrophage-biomaterial-interactions
#14
Claire E Witherel, Pamela L Graney, Kara L Spiller
Tissue engineering and regenerative medicine, facilitated by biomaterial-based therapies, hold promise for the repair, replacement, or regeneration of damaged tissue. The success or failure of all implanted biomaterials, ranging from stainless steel total joint replacements to naturally or synthetically derived skin grafts, is predominantly mediated by macrophages, the primary cell of the innate immune system. In an effort to better assess safety and efficacy of novel biomaterials, evaluating and understanding macrophage-biomaterial interactions is a necessary first step...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29678845/the-use-of-type-i-collagen-cross-linked-c-telopeptide-ctx-1-as-a-biomarker-associated-with-the-formation-of-periprosthetic-ossifications-following-total-hip-joint-arthroplasty
#15
Paweł Łęgosz, Łukasz Pulik, Piotr Stępiński, Jakub Janowicz, Agnieszka Wirkowska, Andrzej Kotela, Sylwia Sarzyńska, Paweł Małdyk
The aim of this study was to determine the co-occurrence of heterotopic ossifications (HO) and elevated bone biomarkers level (urine type I collagen cross-linked C-telopeptide - CTX-1, serum alkaline phosphatase - ALP) and assess the effectiveness of pharmacological prophylaxis of HO. The study group consisted of (N=54) patients qualified for total hip arthroplasty. In N=19 (35%) patients new HO were formed (48th week vs to baseline). On baseline, the mean CTX-1 value in the HO (-) patients was 8.60+/-5.37 ug/mmol vs HO (+) 11...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29676169/thirty-minutes-of-running-exercise-decreases-t2-signal-intensity-but-not-thickness-of-the-knee-joint-cartilage-a-3-0-t-magnetic-resonance-imaging-study
#16
Yiğitcan Karanfil, Naila Babayeva, Gürhan Dönmez, H Barış Diren, Muzaffer Eryılmaz, Mahmut Nedim Doral, Feza Korkusuz
Objective Recent studies showed a potential of magnetic resonance imaging (MRI), which can be used as an additional tool for diagnosing cartilage degeneration in the early stage. We designed a cross-sectional study in order to evaluate knee joint cartilage adaptation to running, using 3.0-T MRI equipped with the 3-dimensional turbo spin echo (VISTA = Volume ISotropic Turbo spin echo Acquisition) software. By this thickness (mm) and signal intensity (mean pixel value) can be quantified, which could be closely related to the fluid content of the knee joint cartilage, before and after running...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29675943/relationship-of-anxiety-with-joint-pain-and-its-management-a-population-survey
#17
Lauren A Barnett, Mark G Pritchard, John J Edwards, Ebenezer K Afolabi, Kelvin P Jordan, Emma L Healey, Andrew G Finney, Carolyn A Chew-Graham, Christian D Mallen, Krysia S Dziedzic
OBJECTIVES: The aims of the present study was to examine the associations between the severity of pain and anxiety in a community population reporting joint pain, and to investigate the management of joint pain in the presence of comorbid anxiety. METHODS: A population survey was carried out of people aged ≥45 years, registered with eight general practices in Cheshire, Shropshire and Staffordshire, UK. Respondents were asked to report pain intensity in their hands, hips, knees and feet (on a numerical rating scale), anxiety symptoms (Generalized Anxiety Disorder seven-item [GAD-7] scale) and guideline-recommended treatments used to manage pain...
April 20, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29675640/effects-of-combined-whole-body-electromyostimulation-and-protein-supplementation-on-local-and-overall-muscle-fat-distribution-in-older-men-with-sarcopenic-obesity-the-randomized-controlled-franconia-sarcopenic-obesity-franso-study
#18
Wolfgang Kemmler, Alexandra Grimm, Michael Bebenek, Matthias Kohl, Simon von Stengel
The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protein supplementation (n = 33) or a non-intervention control group (CG: n = 34). WB-EMS was conducted 1.5 sessions of 20 min/week for 16 weeks. Whey protein supplementation aimed to ensure a daily intake of 1...
April 19, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29675294/multispectral-non-contact-diffuse-optical-tomography-of-healthy-human-finger-joints
#19
Daniel Lighter, James Hughes, Iain Styles, Andrew Filer, Hamid Dehghani
Rheumatoid arthritis (RA) is an inflammatory joint disease often affecting the hands, which if untreated causes disability. Diffuse optical tomography (DOT) provides information about the underlying functional properties of biological tissue. To detect pathophysiological changes in inflamed RA joints, a good understanding of the baseline values for healthy subjects is first required. Finger joints from healthy subjects were imaged using a non-contact, multispectral, continuous wave DOT system, recovering physiological parameters of oxygen saturation, total haemoglobin, water concentration and scatter amplitude...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29675142/reviewing-clinical-effectiveness-of-active-training-strategies-of-platform-based-ankle-rehabilitation-robots
#20
REVIEW
Xiangfeng Zeng, Guoli Zhu, Mingming Zhang, Sheng Q Xie
Objective: This review aims to provide a systematical investigation of clinical effectiveness of active training strategies applied in platform-based ankle robots. Method: English-language studies published from Jan 1980 to Aug 2017 were searched from four databases using key words of "Ankle∗ " AND "Robot∗ " AND "Effect∗ OR Improv∗ OR Increas∗ ." Following an initial screening, three rounds of discrimination were successively conducted based on the title, the abstract, and the full paper...
2018: Journal of Healthcare Engineering
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