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Fenugreek

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https://www.readbyqxmd.com/read/29330279/rare-cause-of-isolated-severe-coagulation-failure-in-cirrhosis-traditional-healing-with-fenugreek
#1
Cyriac A Philips, Philip Augustine
Patients with cirrhosis develop decompensation events during the natural history of the disease that encompass ascites, variceal bleeding, hepatic encephalopathy and jaundice. Coagulation failure, defined using the international normalised ratio, even though not a decompensation event, is important in patients with stratifying cirrhosis into those who require liver transplantation for long-term survival. Isolated coagulation failure in cirrhosis is rare and usually occurs with use of anticoagulants in the setting of vascular diseases...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29277879/trigonelline-insulates-against-oxidative-stress-proinflammatory-cytokines-and-restores-bdnf-levels-in-lipopolysaccharide-induced-cognitive-impairment-in-adult-mice
#2
Amrita A Chowdhury, Nitin B Gawali, Renuka Munshi, Archana R Juvekar
Neuroinflammation is said to play a pivotal role in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). Trigonelline (TRG) is a naturally occurring alkaloid, commonly isolated from fenugreek and coffee beans. In the present study, we investigated whether TRG exerts neuroprotective action against LPS mediated cognitive impairment. Mice pretreated with TRG (50 and 100 mg/kg po) were administered with LPS (250 μg/kg ip) for 7 days. Memory was assessed in the Morris water maze (MWM) and Y maze...
December 26, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29275179/haemato-protective-influence-of-dietary-fenugreek-trigonella-foenum-graecum-l-seeds-is-potentiated-by-onion-allium-cepa-l-in-streptozotocin-induced-diabetic-rats
#3
Seetur R Pradeep, Krishnapura Srinivasan
We have recently reported the beneficial modulation of metabolic abnormalities and oxidative stress in diabetic rats by dietary fenugreek seeds and onion. This investigation evaluated the protective influence of dietary fenugreek seeds (100 g kg-1) and onion (30 g kg-1) on erythrocytes of streptozotocin-induced diabetic rats, through modulation of reduced haematological indices and antisickling potency. This study also evaluated the altered erythrocyte membrane lipid profile and beneficial countering of increased lipid peroxidation, osmotic fragility, along with reduced membrane fluidity and deformability, nitric oxide production and echinocyte formation...
December 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29234367/the-use-of-herbal-remedies-among-mothers-of-young-children-living-in-the-central-appalachian-region
#4
Monira Alwhaibi, Rashmi Goyat, Kimberly M Kelly
Introduction: Women often use herbal remedies as a complement or alternative to traditional medicine. Guided by the Comprehensive Model of Information Seeking, this study examined use of herbal remedies among mothers of young children living in the Central Appalachian Region. Methods: A cross-sectional study was conducted among mothers of young children (n = 178). The outcome measure of interest was the use of any herbal remedy in the past six months. Two scales were developed to measure information seeking channels and to measure beliefs about the safety/efficacy of herbal remedies...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29210166/phytoceuticals-in-fenugreek-ameliorate-vldl-overproduction-and-insulin-resistance-via-the-insig-signaling-pathway
#5
Rituraj Khound, Jing Shen, Yongyan Song, Dipak Santra, Qiaozhu Su
SCOPE: This study aimed to characterize the effect of fenugreek (Trigonella foenum-graecum) seed and its phytoceutical trigonelline in anti-metabolic inflammation and ameliorating overproduction of very low density lipoprotein (VLDL) in insulin resistance. METHODS AND RESULTS: Two groups of genetic hyperlipidemic mice generated by depletion of cAMP responsive binding protein H (CREBH) were fed either a chow containing 2% fenugreek seed or vehicle for 7 weeks. Q-RT-PCR and immunoblotting analysis demonstrated that fenugreek seed containing diet inhibited hepatic SREBP-1c activation and the subsequent de novo lipogenesis by enhancing expression of insulin-inducible gene-1 (Insig-1) and gene-2 (Insig-2)...
December 6, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29209440/efficacy-of-fenugreek-based-bionanocomposite-on-renal-dysfunction-and-endogenous-intoxication-in-high-calorie-diet-induced-obesity-rat-model-comparative-study
#6
Victoria V Konopelniuk, Ievgenii I Goloborodko, Tetyana V Ishchuk, Tetyana B Synelnyk, Ludmila I Ostapchenko, Mykola Ya Spivak, Rostyslav V Bubnov
Background: Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as non-alcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat)...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29204071/the-pharmaceutical-applications-of-a-biopolymer-isolated-from-trigonella-foenum-graecum-seeds-focus-on-the-freeze-dried-matrix-forming-capacity
#7
Sonia Iurian, Elena Dinte, Cristina Iuga, Cătălina Bogdan, Iuliana Spiridon, Lucian Barbu-Tudoran, Andreea Bodoki, Ioan Tomuţă, Sorin E Leucuţa
The aim of the present study was to evaluate the funtion of fenugreek seed mucilage (FSM) as potential matrix forming agent for orodispersible pharmaceutical lyophilisates. The FSM was isolated and characterized. FSM colloidal dispersions were prepared and the rheological evaluation was performed. Oral lyophilisates (OLs) with different FSM concentrations, containing meloxicam as model drug were prepared by freeze drying method. The OLs were characterized and compared to gelatin containing tablets, prepared under the same conditions...
December 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29193352/effectiveness-of-fenugreek-as-a-galactagogue-a-network-meta-analysis
#8
REVIEW
Tahir Mehmood Khan, David Bin-Chia Wu, Anton V Dolzhenko
A systematic review and network-meta analysis (NMA) were performed to test significance of the galactagogue effect of fenugreek administrated to lactating women versus other comparators (i.e., placebo/control/other galactagogues). A pairwise comparison for the treatment effect was carried out to generate the forest plot for the NMA. League tables were generated using treatment effect, weighted mean difference (WMD; 95% confidence interval, CI) for all pairwise comparisons, where WMD > 0 favors the column-defining treatment...
November 30, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29184266/effects-of-saponin-from-trigonella-foenum-graecum-seeds-on-dyslipidemia
#9
Zhi Chen, Yan-Li Lei, Wen-Ping Wang, Ya-Ya Lei, Yan-Hua Liu, Jing Hei, Jin Hu, Hong Sui
Background: Saponins identified from fenugreek (Trigonella foenum-graecum) seeds are reported effective on dyslipidemia. However, the definite mechanism is still not elucidated systematically. In this study, we evaluate the effects of saponin extract on cholesterol absorption, metabolism, synthesis, and reverse cholesterol transport in vivo. Methods: Saponin extract was prepared according to a craft established in our previous study. After the establishment of dyslipidemia model, 40 male Sprague-Dawley rats were divided into five groups, namely the control group (normal diet plus normal saline), HFD group (high fat diet plus normal saline), Lipitor group (high fat diet plus Lipitor (2 mg/kg)), and L, M, and H-saponin groups (high fat diet plus saponin in dosages of 6, 12, and 24 mg/kg, respectively)...
November 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29177779/ethanolic-extract-of-fenugreek-seeds-moderates-dimethoate-induced-pancreatic-damage-in-male-rats
#10
Dalia I A Mesallam, Omaima I Abdel Hamid, Nahla E Ibrahem
Dimethoate is a widely used organophosphate insecticide known to be toxic to the pancreas. The aim of this study is to detect the possible protective effects of the fenugreek seed ethanolic extract on the biochemical, histological, and ultra-structural abnormalities induced by dimethoate chronic exposure in the pancreas of adult male rats. The study was conducted on 50 adult male albino rats that were divided equally into 5 groups: (group I) negative control, (group II) vehicle control group, (group III) fenugreek-treated group that was given 400 mg/kg ethanolic fenugreek seed extract once daily, (group IV) dimethoate group received 20 mg/kg/day dimethoate, and (group V) dimethoate- + fenugreek-treated group received a combination of dimethoate and fenugreek in the same previous doses...
November 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29160624/buccal-patches-of-atenolol-formulated-using-fenugreek-trigonella-foenum-graecum-l-seed-mucilage
#11
Surya Narayan Ratha Adhikari, Satyabrata Panda
BACKGROUND: The use of mucoadhesive natural polymers in designing mucoadhesive patch systems has received much attention. OBJECTIVES: The study involved the development and evaluation of buccal patches of atenolol using fenugreek (Trigonella foenum-graecum L.) seed mucilage with hydroxylpropyl methyl cellulose (HPMC K4M) and a backing membrane (ethyl cellulose 5% w/v). MATERIAL AND METHODS: These atenolol-releasing buccal patches were prepared using a solvent casting technique...
January 2017: Polimery W Medycynie
https://www.readbyqxmd.com/read/29154110/authentication-of-eleutherococcus-and-rhodiola-herbal-supplement-products-in-the-united-kingdom
#12
Markus Ruhsam, Peter M Hollingsworth
Siberian ginseng (Eleutherococcus senticosus, Araliaceae) and roseroot (Rhodiola rosea, Rosaceae) are popular herbal supplements which have been shown to improve resilience to conditions such as stress and exhaustion. Using DNA barcoding methods we tested 25 Siberian ginseng and 14 roseroot products which are widely available to UK customers to test whether the herbal ingredient stated on the label is also in the product. All Siberian ginseng supplements contained E. senticosus, however, 36% also contained an Eleutherococcus species other than E...
November 9, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29122714/diethanolamine-modified-pectin-based-core-shell-composites-as-dual-working-gastroretentive-drug-cargo
#13
Hriday Bera, Sanoj Kumar
The current study aimed at developing diethonolamine-modified high-methoxyl pectin (DMP)-alginate (ALG) based core-shell composites for controlled intragastric delivery of metformin HCl (MFM) by combined approach of floating and bioadhesion. DMP with degree of amidation of 48.72% was initially accomplished and characterized by FTIR, DSC and XRD analyses. MFM-loaded core matrices were then fabricated by ionotropic gelation technique employing zinc acetate as cross-linker. The core matrices were further coated by fenugreek gum (FG)-ALG gel membrane via diffusion-controlled interfacial complexation method...
November 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29122263/knowledge-attitude-and-beliefs-toward-traditional-herbal-medicine-use-among-diabetics-in-jeddah-saudi-arabia
#14
Fatemah O Kamel, Rania M Magadmi, Magda M Hagras, Bashair Magadmi, Reem A AlAhmad
Herbs have long been used in the treatment of diabetes. Therefore, a cross-sectional study of a random sample of diabetic patients was conducted to assess their knowledge, attitude, and beliefs about the use of herbs to control diabetes. Approximately 64% of the patients had previously used herbs for controlling diabetes; 27%, 20.3%, 15.2%, and 10.8% used myrrh, black seeds, fenugreek, and aloe, respectively. Approximately 55.1% patients preferred using herbs to prescription drugs, while 75.2% used herbs with the prescribed medications...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29115455/dioscin-inhibits-ischemic-stroke%C3%A2-induced-inflammation-through-inhibition-of-the-tlr4-myd88-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-a-rat-model
#15
Shilin Zhu, Siyuan Tang, Feng Su
Diosgenin, as an essential natural steroidal saponin, can be extracted from numerous sources, primarily from fenugreek. It is an important raw material for the synthesis of steroid hormone drugs. It exhibits antitumor, anti‑inflammatory, antioxidation and several other significant pharmacologic actions, and is of high pharmaceutical value. In the present study, the activities and underlying mechanisms of dioscin in the inhibition of ischemic stroke in rats were investigated. Inflammatory responses wer analyzed using ELISA kits and caspase‑3 and caspase‑9 activity was analyzed using Caspase‑3 and caspase‑9 activity kits...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29107013/changes-in-fenugreek-transcriptome-induced-by-methyl-jasmonate-and-steroid-precursors-revealed-by-rna-seq
#16
Joanna Ciura, Magdalena Szeliga, Michalina Grzesik, Mirosław Tyrka
Changes in fenugreek transcriptome related to enhanced production of steroids were induced by methyl jasmonate, cholesterol and squalene, and recorded using RNA-seq. A total of 112,850 unigenes were obtained after de novo assembling of next generation sequencing data, and used for functional annotations. In steroidal saponins pathway, transcripts involved in mevalonate, terpenoid backbone and plant sterol synthesis were annotated. Overexpression of several transcripts from phytosterol biosynthesis pathway was confirmed by quantitative RT-PCR...
October 26, 2017: Genomics
https://www.readbyqxmd.com/read/29105723/new-horizons-in-microbiological-food-safety-photodynamic-decontamination-based-on-a-curcumin-derivative
#17
Michael Glueck, Barbara Schamberger, Peter Eckl, Kristjan Plaetzer
Outbreaks of foodborne diseases are regularly reported worldwide. In particular, uncooked plant food is considered risky in terms of microbiological safety. Food is also the most important transmission route for resistant microorganisms from animals to humans. Photodynamic Decontamination (PDc) of foodstuff was recently introduced as a novel approach for increasing microbiological food safety. We investigated the efficiency of PDc on plant food with different geometries (flat, spherical and complex) using a two-dimensional LED array as a light source (435 nm, 33...
November 6, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29103525/extraction-purification-and-characterization-of-galactomannan-from-fenugreek-for-industrial-utilization
#18
Farhat Rashid, Sarfraz Hussain, Zaheer Ahmed
Galactomannan, a water-soluble heteropolysaccharide was isolated and purified from seed of fenugreek locally called as Kasuri Methi. Polysaccharide was chemically characterized and its functional attributes were studied in detail. FTIR analysis divulges representative peaks of polysaccharide in region of 3324, 2914 & 1653cm(-1). Galactomannan depicted lower water holding capacity compared to guar gum. Emulsifying activity and emulsion stability of biopolymer was on higher side as compare to reference material...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29097216/antimicrobial-antioxidant-and-anticancer-activities-of-zinc-nanoparticles-prepared-by-natural-polysaccharides-and-gamma-radiation
#19
Ahmed I El-Batal, Farag M Mosalam, M M Ghorab, Amro Hanora, Ahmed M Elbarbary
Aqueous dispersed zinc nanoparticles (ZnNPs) were synthesized using natural polysaccherides (chitosan (CS), citrus pectin (CP) and alginate (Alg)) using aqueous fermented fenugreek powder (FFP) by Pleurotus ostreatus as reducing and stabilizing agent or using gamma irradiation. The synthesized ZnNPs are characterized by ultra violect spectroscopy (UV), Transmission electronmicroscopy (TEM), Dynamic light scattering (DLS), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). XRD analysis of the ZnNPS confirmed the formation of metallic nanoparticles...
October 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29094243/alleviation-of-cardiac-damage-by-dietary-fenugreek-trigonella-foenum-graecum-seeds-is-potentiated-by-onion-allium-cepa-in-experimental-diabetic-rats-via-blocking-renin-angiotensin-system
#20
Seetur R Pradeep, Krishnapura Srinivasan
Hyperglycemia is one of the metabolic and homeostatic abnormalities that increase the cardiovascular mortality in diabetic patients by increased oxidative stress. We have recently reported amelioration of oxidative stress in cardiac tissue by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in streptozotocin-induced diabetic rats. The mechanistic aspects of the cardio-protective influence of dietary fenugreek seeds (10%) and onion (3% powder) both individually and in combination on hyperglycemia-mediated cardiac damage was further investigated in this study on streptozotocin-induced diabetic rats...
November 1, 2017: Cardiovascular Toxicology
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