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https://www.readbyqxmd.com/read/27914964/antioxidant-and-hemolytic-activities-and-effects-in-rat-cutaneous-wound-healing-of-a-novel-polysaccharide-from-fenugreek-trigonella-foenum-graecum-seeds
#1
Naourez Ktari, Imen Trabelsi, Sana Bardaa, Mehdi Triki, Intidhar Bkhairia, Rabab Ben Slama-Ben Salem, Moncef Nasri, Riadh Ben Salah
The aim of this work was to evaluate the antioxidant and hemolytic activities as well as the in vivo wound healing performance of a novel polysaccharide (FWEP) extracted from fenugreek (Trigonella foenum-graecum) seeds. The antioxidant activity was evaluated in vivo and in vitro using various assays. Results showed that FWEP exhibited strong antioxidant activities but no hemolytic activity was observed towards bovine erythrocytes. The application of FWEP hydrogel on the wound site in a rat model enhanced significantly wound healing activity and accelerated the wound closure after 14days of wound induction...
November 30, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27895489/health-provider-experiences-with-galactagogues-to-support-breastfeeding-a-cross-sectional-survey
#2
Alessandra N Bazzano, Lisa Littrell, Amelia Brandt, Shelley Thibeau, Kamala Thriemer, Katherine P Theall
BACKGROUND: Exclusive breastfeeding for infants up to 6 months is widely recommended, yet breastfeeding rates are relatively low in the US. The most common reason women stop breastfeeding early is a perceived insufficiency of milk. Galactagogues are herbal and pharmaceutical products that can help increase milk supply; however, data on their efficacy and safety is limited. Lactation consultants, obstetricians, and other health providers are an important point of contact for breastfeeding women experiencing challenges with lactation...
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27893738/fenugreek-seed-powder-nullified-aluminium-chloride-induced-memory-loss-biochemical-changes-a%C3%AE-burden-and-apoptosis-via-regulating-akt-gsk3%C3%AE-signaling-pathway
#3
Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Mohammed D Akbar, Mohammed Akbar
Alzheimer's disease (AD) is the most common form of dementia that mainly affects the cognitive functions of the aged populations. Trigonella foenum-graecum (L.) (fenugreek), a traditionally well utilized medicinal plant ubiquitously used as one of the main food additive worldwide, is known to have numerous beneficial health effects. Fenugreek seed extract could be able to inhibit the activity of acetylcholinesterase (AChE), a key enzyme involved in the pathogenesis of AD, and further shown to have anti-parkinsonic effect...
2016: PloS One
https://www.readbyqxmd.com/read/27879673/4-hydroxyisoleucine-from-fenugreek-trigonella-foenum-graecum-effects-on-insulin-resistance-associated-with-obesity
#4
REVIEW
Anaguiven Avalos-Soriano, Ricardo De la Cruz-Cordero, Jorge L Rosado, Teresa Garcia-Gasca
Obesity and insulin resistance (IR) are interdependent multifactorial processes that cannot be understood separately. Obesity leads to systemic inflammation and increased levels of free fatty acids that provoke IR and lipotoxicity. At the same time, IR exacerbates adipose cell dysfunction, resulting in chronic inflammation and major lipotoxic effects on nonadipose tissues. 4-Hydroxyisoleucine (4-OHIle), a peculiar nonprotein amino acid isolated from fenugreek (Trigonella foenum-graecum) seeds, exhibits interesting effects on IR related to obesity...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27856325/effects-of-dietary-administration-of-fenugreek-seeds-alone-or-in-combination-with-probiotics-on-growth-performance-parameters-humoral-immune-response-and-gene-expression-of-gilthead-seabream-sparus-aurata-l
#5
A Bahi, F A Guardiola, C Messina, A Mahdhi, R Cerezuela, A Santulli, A Bakhrouf, M A Esteban
The use of immunostimulants is considered a promising preventive practice that may help to maintain animal welfare and a healthy environment, while increasing production and providing higher profits. The purpose of this study was to evaluate the effects on gilthead seabream (Sparus aurata L.) of the dietary administration of fenugreek (Trigonella foenum graecum) seeds, alone or combined with one of the following probiotic strains: Bacillus licheniformis (TSB27), Lactobacillus plantarum or Bacillus subtilis (B46)...
November 14, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27822173/preclinical-safety-evaluation-of-low-molecular-weight-galactomannans-based-standardized-fenugreek-seeds-extract
#6
Pallavi Deshpande, Vishwaraman Mohan, Prasad Thakurdesai
The objective of the present study was to evaluate acute oral toxicity, subchronic toxicity, and mutagenic potential of low molecular weight galactomannans based standardized fenugreek seeds extract (LMWGAL-TF) in laboratory animals rats as per Organization for Economic Co-operation and Development (OECD) guidelines. For the acute toxicity (AOT) study, LMWGAL-TF was orally administered to Sprague-Dawley (SD) rats at a dose of 2000 mg/kg with vehicle control (VC) group (n = 5 per sex per group) as per OECD guideline no...
2016: EXCLI journal
https://www.readbyqxmd.com/read/27773753/acute-and-repeated-doses-28-days-oral-toxicity-study-of-vicenin-1-a-flavonoid-glycoside-isolated-from-fenugreek-seeds-in-laboratory-mice
#7
Amit D Kandhare, Subhash L Bodhankar, V Mohan, Prasad A Thakurdesai
Vicenin-1 (fenugreek glycoside) has been proven to possess potent anti-inflammatory and anti-oxidant activity. The objective of the present investigation was to determine in-vivo acute and subacute (28-days repeated dose) oral toxicity of Vicenin-1 isolated from fenugreek seed. Vicenin-1 (93%) was isolated from a hydroalcoholic extract of fenugreek seed and characterized using HPLC, TLC, (1)H NMR and (13)C NMR. Acute oral toxicity (AOT) and subacute toxicity studies of Vicenin-1 were carried out according to OECD 425 (up-and-down procedure) and OCED 407 guidelines in Swiss albino mice...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27756958/anti-inflammatory-activity-of-fenugreek-trigonella-foenum-graecum-linn-seed-petroleum-ether-extract
#8
Kilambi Pundarikakshudu, Deepak H Shah, Aashish H Panchal, Gordhanbhai C Bhavsar
OBJECTIVES: The aim of the present work was to study the anti-inflammatory and anti-arthritic activities of petroleum ether extract of fenugreek seeds. MATERIALS AND METHODS: Fenugreek seed powder was extracted in petroleum ether by cold maceration. This fenugreek seed petroleum ether extract (FSPEE) was analyzed by gas-liquid chromatography (GLC) and tested on rats against carrageenan and formaldehyde-induced paw edema, complete Freund's adjuvant (CFA)-induced arthritis and cotton pellet-induced granuloma...
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27733237/a-multicenter-clinical-study-to-determine-the-efficacy-of-a-novel-fenugreek-seed-trigonella-foenum-graecum-extract-fenfuro%C3%A2-in-patients-with-type-2-diabetes
#9
Narsingh Verma, Kauser Usman, Naresh Patel, Arvind Jain, Sudhir Dhakre, Anand Swaroop, Manashi Bagchi, Pawan Kumar, Harry G Preuss, Debasis Bagchi
BACKGROUND: Trigonella foenum-graecum (fenugreek) seeds are known to exhibit potent antioxidant, hypoglycemic, and nephroprotective activities, as well as serve as excellent membrane stabilizers especially because of their content of novel furostanolic saponins. Our previous studies exhibited the broad spectrum safety and efficacy of Fenfuro, a novel T. foenum-graecum seed extract enriched in furostanolic saponins, in type 2 diabetes (T2D) in rats. DESIGN: This multicenter, randomized, placebo-controlled, double-blind, add-on clinical study evaluated over a period of 90 consecutive days the efficacy of Fenfuro (daily dosage: 500 mg bid) in 154 subjects (male: 108; female: 46; age: 25-60 years) with T2D...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27677719/botanicals-and-their-bioactive-phytochemicals-for-women-s-health
#10
Birgit M Dietz, Atieh Hajirahimkhan, Tareisha L Dunlap, Judy L Bolton
Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber officinale (ginger)...
October 2016: Pharmacological Reviews
https://www.readbyqxmd.com/read/27650031/review-weak-radiofrequency-radiation-exposure-from-mobile-phone-radiation-on-plants
#11
Malka N Halgamuge
AIM: The aim of this article was to explore the hypothesis that non-thermal, weak, radiofrequency electromagnetic fields (RF-EMF) have an effect on living plants. SUBJECT AND METHODS: In this study, we performed an analysis of the data extracted from the 45 peer-reviewed scientific publications (1996-2016) describing 169 experimental observations to detect the physiological and morphological changes in plants due to the non-thermal RF-EMF effects from mobile phone radiation...
September 20, 2016: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/27619931/supplements-for-diabetes-mellitus-a-review-of-the-literature
#12
Zera Yilmaz, Fawad Piracha, Leeann Anderson, Nissa Mazzola
The primary approach to controlling diabetes involves diet and lifestyle modification combined with pharmacologic interventions. Patients who are interested in exploring dietary supplements in the management of diabetes may have questions about which supplement to choose and whether any issues will arise with their current medication regimen. After reading this review, the pharmacist should be able to identify supplements that may provide benefit to improve diabetes management, understand what potential harm to the patient may occur, and be able to assist the patient in choosing high-quality supplements...
September 11, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27581008/uptake-and-distribution-of-minerals-and-heavy-metals-in-commonly-grown-leafy-vegetable-species-irrigated-with-sewage-water
#13
Sumera Anwar, Muhammad Farrakh Nawaz, Sadaf Gul, Muhammad Rizwan, Shafaqat Ali, Arshaad Kareem
Heavy metal uptake and accumulation behavior in dietary vegetables irrigated with sewage waters is an important issue worldwide. The main objective of this study was to examine and compare the physiological and growth responses of leafy vegetables irrigated with sewage water. A pot experiment was conducted in a wire house with three leafy vegetables, coriander (Coriandrum sativum), mint (Mentha arvensis), and fenugreek (Trigonella foenum), grown under ambient conditions. Plants were irrigated with different concentrations, 0, 50 (T 1), and 100 % (T 2), of sewage water...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27498339/toxicological-properties-of-fenugreek-trigonella-foenum-graecum
#14
REVIEW
Mounir Ouzir, Khalid El Bairi, Saaïd Amzazi
Fenugreek (Trigonella foenum graecum), used as traditional medicine and natural additive food, has been shown to exert significant antiatherogenic, antidiabetic, antianorexic, antioxidant, anticarcinogenic, antihyperlipidemic, galactogogue and anti-inflammatory effects in several human and animal models. Besides, several medicinal pharmaceutical and nutraceutical properties, fenugreek have toxic effects as well. The aim of this review is discuss the cumulative evidence, which suggests that consumption of fenugreek induced some serious toxicological side effects...
October 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27496582/effect-of-fenugreek-on-hyperglycaemia-and-hyperlipidemia-in-diabetes-and-prediabetes-a-meta-analysis
#15
Jing Gong, Ke Fang, Hui Dong, Dingkun Wang, Meilin Hu, Fuer Lu
ETHNOPHARMACOLOGICAL RELEVANCE: Fenugreek is a widely used herb for the treatment of diabetes mellitus (DM) but the effects in randomized controlled trials (RCTs) were controversial. Therefore, a meta-analysis was conducted to estimate the overall effects of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes. MATERIALS AND METHODS: PubMed, EMBASE, web of science, Chinese Biomedical Literature database (CBM), the Cochrane library, China Doctor Dissertations Full-text Database (CDFD), Wan Fang medical database, China Proceedings of Conference Full-text Database (CPCD), China national knowledge internet (CNKI) and China Master's Theses Full-text Database (CMFD) were searched to find the available literatures...
August 2, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27406028/a-novel-extract-of-fenugreek-husk-fenusmart%C3%A2-alleviates-postmenopausal-symptoms-and-helps-to-establish-the-hormonal-balance-a-randomized-double-blind-placebo-controlled-study
#16
S Shamshad Begum, H K Jayalakshmi, H G Vidyavathi, G Gopakumar, Issac Abin, Maliakel Balu, K Geetha, S V Suresha, M Vasundhara, I M Krishnakumar
Despite the widespread use of hormone replacement therapy, various reports on its side effects have generated an increasing interest in the development of safe natural agents for the management of postmenopausal discomforts. The present randomized, double-blinded, placebo-controlled study investigated the effect of 90-day supplementation of a standardized extract of fenugreek (Trigonella foenum-graecum) (FenuSMART™), at a dose of 1000 mg/day, on plasma estrogens and postmenopausal discomforts. Eighty-eight women having moderate to severe postmenopausal discomforts and poor quality of life (as evidenced from the scores of Greene Climacteric Scale, short form SF-36® and structured medical interview) were randomized either to extract-treated (n = 44) or placebo (n = 44) groups...
July 13, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27375259/long-term-survival-of-the-shiga-toxin-producing-escherichia-coli-o104-h4-outbreak-strain-on-fenugreek-seeds
#17
Michael Knödler, Michael Berger, Ulrich Dobrindt
A major outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 occurred in Germany in 2011. The epidemiological investigation revealed that a contaminated batch of fenugreek seeds (Trigonella foenum-graecum) was the most probable source of the pathogen. It was suggested that the most probable point of contamination was prior to leaving the importer, meaning that the seed contamination with STEC O104:H4 should have happened more than one year before the seeds were used for sprout production. Here, we investigated the capacity of STEC O104:H4 and closely related pathogenic as well as non-pathogenic Escherichia coli strains for long-term survival on dry fenugreek seeds...
October 2016: Food Microbiology
https://www.readbyqxmd.com/read/27307778/fenugreek-a-multipurpose-crop-potentialities-and-improvements
#18
REVIEW
Awais Ahmad, Salem S Alghamdi, Kaiser Mahmood, Muhammad Afzal
Fenugreek is one of the oldest medicinal plants with exceptional medicinal and nutritional profile. Fenugreek seeds contain a substantial amount of fiber, phospholipids, glycolipids, oleic acid, linolenic acid, linoleic acid, choline, vitamins A, B1, B2, C, nicotinic acid, niacin, and many other functional elements. It may grow well under diverse and a wide range of conditions; it is moderately tolerant to drought and salinity, and can even be grown on marginal lands in profitable way. Owing to these characteristics and heavy metal remediation potential, fenugreek may well fit several cropping systems...
March 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27296605/in-vitro-antiviral-activity-of-clove-and-ginger-aqueous-extracts-against-feline-calicivirus-a-surrogate-for-human-norovirus
#19
Hamada A Aboubakr, Andrew Nauertz, Nhungoc T Luong, Shivani Agrawal, Sobhy A A El-Sohaimy, Mohammed M Youssef, Sagar M Goyal
Foodborne viruses, particularly human norovirus, are a concern for public health, especially in fresh vegetables and other minimally processed foods that may not undergo sufficient decontamination. It is necessary to explore novel nonthermal techniques for preventing foodborne viral contamination. In this study, aqueous extracts of six raw food materials (flower buds of clove, fenugreek seeds, garlic and onion bulbs, ginger rhizomes, and jalapeño peppers) were tested for antiviral activity against feline calicivirus (FCV) as a surrogate for human norovirus...
June 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/27284222/influence-of-combinations-of-fenugreek-garlic-and-black-pepper-powder-on-production-traits-of-the-broilers
#20
A Kirubakaran, M Moorthy, R Chitra, G Prabakar
AIM: To study the effects of combinations of fenugreek (Trigonella foenum-graecum L.), garlic (Allium sativum), and black pepper (Piper nigrum) powder supplementation on production traits of broiler chickens. MATERIALS AND METHODS: A total of 288 commercial broiler chicks were randomly assigned to 1-9 groups with 4 replicates each. An experiment was conducted in broilers with different feed formulations; control feed, with no added fenugreek, garlic, and black pepper powder; and 8 treatment groups receiving feed supplemented with different combinations of fenugreek, garlic, and black pepper powder...
May 2016: Veterinary World
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