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https://www.readbyqxmd.com/read/28729836/an-overview-of-herbal-products-and-secondary-metabolites-used-for-management-of-type-two-diabetes
#1
REVIEW
Ajda Ota, Nataša P Ulrih
Diabetes mellitus is a common effect of uncontrolled high blood sugar and it is associated with long-term damage, dysfunction, and failure of various organs. In the adult population, the global prevalence of diabetes has nearly doubled since 1980. Without effective prevention and management programs, the continuing significant rise in diabetes will have grave consequences on the health and lifespan of the world population, and also on the world economy. Supplements can be used to correct nutritional deficiencies or to maintain an adequate intake of certain nutrients...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28702918/assessment-of-potential-health-risk-of-fluoride-consumption-through-rice-pulses-and-vegetables-in-addition-to-consumption-of-fluoride-contaminated-drinking-water-of-west-bengal-india
#2
Piyal Bhattacharya, Alok Chandra Samal, Suman Banerjee, Jagadish Pyne, Subhas Chandra Santra
A study was conducted in fluoride-affected Bankura and Purulia districts of West Bengal to assess the potential health risk from fluoride exposure among children, teenagers, and adults due to consumption of rice, pulses, and vegetables in addition to drinking water and incidental ingestion of soil by children. Higher mean fluoride contents (13-63 mg/kg dry weight) were observed in radish, carrot, onion bulb, brinjal, potato tuber, cauliflower, cabbage, coriander, and pigeon pea. The combined influence of rice, pulses, and vegetables to cumulative estimated daily intake (EDI) of fluoride for the studied population was found to be 9...
July 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28698493/antifungal-and-antiochratoxigenic-activities-of-essential-oils-and-total-phenolic-extracts-a-comparative-study
#3
Rachelle El Khoury, Ali Atoui, Florence Mathieu, Hiba Kawtharani, Anthony El Khoury, Richard G Maroun, Andre El Khoury
This study is intended to prevent ochratoxin A (OTA) production by Aspergillus carbonarius S402 using essential oils (EOs) and total phenolic compounds extracted from plants and herbs. The EOs used in this study are the following: bay leaves, cumin, fenugreek, melissa, mint, and sage. As for the phenolic compounds, they were extracted from bay leaves, cumin, fenugreek, melissa, mint, sage, anise, chamomile, fennel, rosemary, and thyme. The experiments were conducted on Synthetic Grape Medium (SGM) medium at 28 °C for 4 days...
July 9, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28679380/a-novel-botanical-formula-prevents-diabetes-by-improving-insulin-resistance
#4
Juntao Kan, Rodney A Velliquette, Kerry Grann, Charlie R Burns, Jeff Scholten, Feng Tian, Qi Zhang, Min Gui
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease, and the prevalence has increased significantly in recent decades to epidemic proportions in China. Individually, fenugreek (Trigonella foenum graecum) seed, mulberry (Morus alba L.) leaf and American ginseng (Panax quinquefolius) root can improve glycemia in various animal models and humans with impaired glucose metabolism and T2DM. The aim of this study was to design an optimized botanical formula containing these herbal extracts as a nutritional strategy for the prevention of insulin resistance and T2DM...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28663151/a-comparison-of-chemical-structural-and-functional-properties-of-fenugreek-trigonella-foenum-graecum-protein-isolates-produced-using-different-defatting-solvents
#5
Samira Feyzi, Mehdi Varidi, Fatemeh Zare, Mohammad Javad Varidi
This study showed defatting solvents including hexane, diethyl ether, chloroform, ethanol and acetone, due to their influence on protein denaturation and structure, have considerable effect on the amino acid composition, thermal characterizations, surface and functional properties of fenugreek protein isolate. FTIR analysis while confirmed the presence of secondary structures in all fenugreek protein isolates, showed differences in these structures. Hexane and diethyl ether resulted in comparable coagulated protein, interfacial tension, emulsifying properties, surface hydrophobicity, Td and SDS-PAGE profile in fenugreek protein isolates...
June 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28634713/characterization-and-in-vitro-antibacterial-activity-of-saponin-conjugated-silver-nanoparticles-against-bacteria-that-cause-burn-wound-infection
#6
Anbarasan Muniyan, Kalaiselvi Ravi, Udayamathi Mohan, Rajasekar Panchamoorthy
Saponins are glycosides, which destabilize the membrane by altering the membrane permeability. Thus, the present study was aimed to fabricate the silver nanoparticles (AgNPs) using fenugreek derived saponin (SN) against multi-drug resistant bacteria. This study has optimized the concentration of SN (240 mg/mL) for the synthesis of an effective AgNPs against the test organism Escherichia coli. The SN reduced AgNPs produced a reddish-brown colour and displayed UV absorption at 416 nm. The bio-reducing efficiency of SN (62...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28610933/herbal-laxatives-and-antiemetics-in-pregnancy
#7
Reza Samavati, Eszter Ducza, Judit Hajagos-Tóth, Robert Gaspar
Constipation appears in the 2nd and 3rd trimester of pregnancy, while nausea is the strongest in the 1st trimester. This review summarizes the applicability of herbal laxatives and antiemetics in pregnancy. A human study has shown that flax oil as laxative is safe from 2nd trimester. Human data is not available about the rhubarb, but animal studies reveal that its emodin content induces fetal abnormalities. Fenugreek induces teratogenic malformation both in human and animals. Senna seed is proved as a safe laxative in pregnancy...
June 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28599386/amelioration-of-hyperglycemia-and-associated-metabolic-abnormalities-by-a-combination-of-fenugreek-trigonella-foenum-graecum-seeds-and-onion-allium-cepa-in-experimental-diabetes
#8
Seetur R Pradeep, Krishnapura Srinivasan
BACKGROUND: Fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) are independently known to have antidiabetic effects through different mechanisms. The beeneficial influence of a combination of dietary fenugreek seeds and onion on hyperglycemia and its associated metabolic abnormalities were evaluated in streptozotocin-induced diabetic rats. METHODS: Diabetes was experimentally induced with streptozotocin and diabetic rats were fed with 10% fenugreek or 3% onion or their combination for 6 weeks...
May 24, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28581555/investigation-of-mechanisms-involved-in-postprandial-glycemia-and-insulinemia-attenuation-with-dietary-fibre-consumption
#9
Nikolay Repin, Brittney A Kay, Steve W Cui, Amanda J Wright, Alison M Duncan, H Douglas Goff
This work examines the mechanisms involved in the attenuation of postprandial glycemic and insulinemic responses associated with soluble dietary fibre (SDF) consumption. The effect of SDF, including yellow mustard mucilage, soluble flaxseed gum and fenugreek gum on in vitro amylolysis and maltose transport was studied. Furthermore, a human clinical trial was conducted to investigate the effect of SDF consumption on postprandial glycemic and insulinemic responses and gastric emptying, as estimated based on the absorption of paracetamol...
June 5, 2017: Food & Function
https://www.readbyqxmd.com/read/28566642/modulatory-effect-of-an-isolated-triglyceride-from-fenugreek-seed-oil-on-of-%C3%AE-amylase-lipase-and-ace-activities-liver-kidney-functions-and-metabolic-disorders-of-diabetic-rats
#10
Khaled Hamden, Henda Keskes, Othman Elgomdi, Abdelfattah Feki, Noureddine Alouche
This study was designed to examine physicochemical characteristics, chemical compositions and biological activities of fenugreek seed oil (FSO) and its pure triglyceride (TG). One fenugreek TG was purified using a bioassay-guided fractionation and administrated to surviving diabetic rats. The free fatty acids percentage as well as, the peroxide, the saponification and the iodine values were 2%, 12 mequiv. O2/kg of oil, 189 (mg KOH/g) and 110 (g/100 g of oil), respectively. Linolenic acid (C18:3 26.14%), Linoleic acid (C18:2 41...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28558255/anti-inflammatory-subfractions-separated-from-acidified-chloroform-fraction-of-fenugreek-seeds-trigonella-foenum-graecum-l
#11
Mostafa Pournamdari, Ali Mandegary, Fariba Sharififar, Ghazaleh Zarei, Rahele Zareshahi, Amir Asadi, Mohammad Mehdipour
Considering the side effects of current anti-inflammatory drugs, novel therapeutic agents are desired. We have succeeded in separating flavonoid-rich fractions with anti-inflammatory effect from fenugreek seeds (Trigonella foenum-graecum L.). In this work, we aimed to carry out further fractionation to find active anti-inflammatory subfractions. Trigonelline content of the plant was determined by spectrophotometric method. Fenugreek seeds were extracted consecutively with petroleum ether, acidified chloroform (ACC), alkaline chloroform (AKC), methanol, and water...
May 30, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28539737/preclinical-toxicological-evaluation-of-idm01-the-botanical-composition-of-4-hydroxyisoleucine-and-trigonelline-based-standardized-fenugreek-seed-extract
#12
Pallavi O Deshpande, Vishwaraman Mohan, Prasad Arvind Thakurdesai
OBJECTIVE: To evaluate acute oral toxicity (AOT), subchronic (90-day repeated dose) toxicity, mutagenicity, and genotoxicity potential of IDM01, the botanical composition of 4-hydroxyisoleucine- and trigonelline-based standardized fenugreek (Trigonella foenum-graecum L) seed extract in laboratory rats. MATERIALS AND METHODS: The AOT and subchronic (90-day repeated dose) toxicity were evaluated using Sprague-Dawley rats as per the Organisation for Economic Co-operation and Development (OECD) guidelines No...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28536016/production-and-characterization-of-a-new-biodegradable-fenugreek-seed-gum-based-active-nanocomposite-film-reinforced-with-nanoclays
#13
Saliha Memiş, Fatih Tornuk, Fatih Bozkurt, M Zeki Durak
In the present work, fenugreek seed gum (FSG)/clay nanocomposite films were prepared with nanoclays (Na(+) montmorillonite [MMT], halloysite [HNT] and Nanomer(®) I.44 P [NM]) at different amounts (0, 2.5, 5.0 and 7.5g clay/100g FSG) by solution casting method and characterized. Increasing amount of nanoclay significantly (P<0.05) improved oxygen barrier and thermal properties of the biodegradable films. Agar diffusion tests revealed that FSG based nanocomposite films exhibited strong antimicrobial properties against foodborne pathogens namely Listeria monocytogenes, Escherichia coli O157:H7, Staphylococcus aureus and Bacillus cereus independently of clay type and concentration...
May 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28504078/a-review-on-therapeutic-potentials-of-trigonella-foenum-graecum-fenugreek-and-its-chemical-constituents-in-neurological-disorders-complementary-roles-to-its-hypolipidemic-hypoglycemic-and-antioxidant-potential
#14
Saima Zameer, Abul Kalam Najmi, Divya Vohora, Mohd Akhtar
OBJECTIVES: The growing rate of neurological disorders is a major concern in today's scenario. Today's research is focusing on therapeutic interventions providing benefits in these disorders. Presently, drugs of natural origin have gained more interest for the treatment of central nervous system disorders for their efficacy and less/ no side effects. This review is emphasizing the cited roles of Trigonella foenum graecum (fenugreek) and its constituents in different neurological manifestations...
May 15, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28484691/inflammatory-effects-of-the-plant-protection-product-stifenia-fen560-on-vertebrates
#15
Lény Teyssier, Julie Colussi, Stéphanie Delemasure, Johanna Chluba, David Wendehenne, Olivier Lamotte, Jean-Louis Connat
Plant defense stimulators (PDSs) rely on the activation of plant innate immunity in order to protect crops against various pests. These molecules are thought to be a safer alternative to classical plant protection products. Given that innate immune systems share common features in plants and vertebrates, PDS can potentially cross-react with innate immunity of non-target organisms. To test this hypothesis, we studied effects of the commercial PDS Stifenia (FEN560), which is composed of crushed fenugreek seeds...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28479738/prenatal-developmental-toxicity-study-of-glycosides-based-standardized-fenugreek-seed-extract-in-rats
#16
Pallavi O Deshpande, Vishwaraman Mohan, Mukul P Pore, Shailesh Gumaste, Prasad A Thakurdesai
CONTEXT: Glycoside-based standardized fenugreek seed extract (SFSE-G) demonstrated promising efficacy in animal models of immune-inflammatory conditions. AIM: The present study was aimed at embryo-fetal development toxicity evaluation of SFSE-G in Wistar rats as per guideline No. 414 of the Organization for Economic Co-operation and Development (OECD). MATERIAL AND METHODS: Mated female rats were randomized into four groups of 30 each and received oral doses of either SFSE-G at 250, 500, and 1000 mg/kg or vehicle (water) during the period of gestation (postconception) from gestational day 5 (GD5, an implantation day) until 1 day before cesarean sections (GD19)...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28433714/effects-of-dietary-supplementation-with-fenugreek-seeds-alone-or-in-combination-with-probiotics-on-gilthead-seabream-sparus-aurata-l-skin-mucosal-immunity
#17
F A Guardiola, A Bahi, A Bakhrouf, M A Esteban
Despite increasing interest in modulating the immune response of fish, providing a combination of probiotics and herbal immunostimulants in aquafeed has rarely has been studied. The effects on gilthead seabream (Sparus aurata L.) of the dietary administration of fenugreek (Trigonella foenum graecum) seeds alone (FE), or combined with one of the following probiotic strains: Bacillus licheniformis (FEBL), Lactobacillus plantarum (FELP) or Bacillus subtilis (FEBS) were evaluated. Fish were fed a control or one of the supplemented diets for 3 weeks...
April 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28407664/fenugreek-a-potent-hypoglycaemic-herb-can-cause-central-hypothyroidism-via-leptin-a-threat-to-diabetes-phytotherapy
#18
Jayjeet Majumdar, Pratip Chakraborty, Analava Mitra, Nirmal Kumar Sarkar, Supriti Sarkar
Fenugreek (Trigonella foenum graecum), a medicinal herb with potent antihyperglycaemic and hypoglycaemic effects, is used to treat diabetes. This study is aimed to explore the interaction of fenugreek seed extract (FSE) and HPT (hypothalamic-pituitary-thyroid) axis in context of leptin secretion which have important role in normal and type-1 diabetic subjects. FSE (confirmed to contain trigonelline, diosgenin, 4 hydroxyisoleucine) was gavaged (0.25 gm/kg body weight/day) to normal and alloxan-induced type-1 diabetic rats for 4 weeks...
July 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28391170/anticancer-potential-of-trigonella-foenum-graecum-cellular-and-molecular-targets
#19
REVIEW
Khalid El Bairi, Mounir Ouzir, Najda Agnieszka, Loubna Khalki
A growing body of evidence supported by numerous studies on tumorigenesis confirms that it is possible to target various hallmarks of cancer. Recent studies have shown that plant-derived molecules may be used in targeting different signaling pathways for cancer drug discovery. The present paper gives an insight into the anticancer potential of fenugreek and lists the existing studies that have been carried out to demonstrate the advantages of the use of fenugreek in cancer treatment and prevention. It also aims at opening up new perspectives in the development of new drugs of natural origins in the future clinical trials...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28367866/degradation-of-total-petroleum-hydrocarbon-tph-in-contaminated-soil-using-bacillus-pumilus-mvsv3
#20
Surendra Sheeba Varma, Mahalingam Brinda Lakshmi, Perumalsam Rajagopal, Manickam Velan
 A study on bioremediation of soil contaminated with petroleum sludge was performed using Bacillus pumilus/MVSV3 (Accession number JN089707). In this study, 5 kg of agricultural soil was mixed well with 5% oil sludge and fertilizers containing nitrogen, phosphorus and potassium (N:P:K). The treatment resulted in 97% removal of total petroleum hydrocarbon (TPH) in 122 d in bacteria mixed contaminated soil when compared to 12% removal of TPH in uninoculated contaminated soil. The population of the microorganism remained stable after introduced into the oil environment...
2017: Biocontrol Science
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