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Ovarian angiosarcoma

Erik Kudela, Marcela Nachajova, Kamil Biringer, Pavol Slavik, Lukas Plank, Jan Danko
INTRODUCTION: Ovarian teratomas undergo the malignant transformation in 0.2-2% of cases. The behavior of malignancies in mature cystic teratomas (MCT) is determined by their phenotype and not their derivation from germ cells. We can recognize pure angiosarcomas or as a part of other tumors like malignant mixed Mullerian tumors and adenosarcomas. PRESENTATION OF CASE: We present the first case of bilateral ovarian angiosarcoma arising from the mature teratomas. Due to widespread disease, we performed limited surgical procedure consisting of bilateral adnexectomy and omentectomy...
2018: International Journal of Surgery Case Reports
Steven L Rains, Clarissa N Amaya, Brad A Bryan
Based largely on retrospective analyses and a handful of prospective case reports, pharmacological inhibition of the beta adrenergic receptors using beta blockers has shown clinical anti-cancer efficacy in reproductive cancers, as well as angiosarcoma and multiple myeloma. Because of the potential promise of beta blockers as an adjunct to standard anti-cancer therapy, it is imperative to identify other tumor types expressing beta adrenergic (β-AR) receptors so future preclinical and clinical studies can be directed at the most promising tumor targets...
July 2017: Oncoscience
Tchin Darré, Abdoul-Samadou Aboubakari, Bingo K N'Bortche, Akila Bassowa, Solange Adani-Ifé, Gado Napo-Koura
BACKGROUND: Ovarian sarcomas represent less than 1% of all ovary cancers and usually are frequent in adults. Primary angiosarcomas are exceptional in the ovaries within children. CASE PRESENTATION: We reported a case of primary ovarian angiosarcoma in a 12-year-old girl in a resource-constrained context. Immunohistochemistry study showed the positivity of CD34, CD31, factor VIII, while S100 was negative. The diagnosis of primary non-metastatic angiosarcoma was retained...
2017: BMC Clinical Pathology
Chung Kuao Chou, Shih-Cheng Chou
The commonly seen primary malignant neoplasms of the spleen are angiosarcoma and lymphoma. We present a case of serous cystadenocarcinoma of the spleen. It was presumed to be originated from dropped nonmalignant ovarian tissue, which was accidentally implanted to the splenic surface during hysterectomy and bilateral salpingooophorectomies for torsion of right fallopian tube 9 and half years ago and transformed into serous cystadenocarcinoma later. Computed tomography demonstrated a multilocular predominantly cystic tumor with internal soft tissue components in the spleen...
June 2017: Radiology Case Reports
Robert Roskoski
ROS1 protein-tyrosine kinase fusion proteins are expressed in 1-2% of non-small cell lung cancers. The ROS1 fusion partners include CD74, CCDC6, EZR, FIG, KDELR2, LRIG3, MSN, SDC4, SLC34A2, TMEM106B, TMP3, and TPD52L1. Physiological ROS1 is closely related to the ALK, LTK, and insulin receptor protein-tyrosine kinases. ROS1 is a so-called orphan receptor because the identity of its activating ligand, if any, is unknown. The receptor is expressed during development, but little is expressed in adults and its physiological function is unknown...
July 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Surapan Khunamornpong, Jongkolnee Settakorn, Kornkanok Sukpan, Tip Pongsuvareeyakul, Sumalee Siriaunkgul
Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. The purpose of this report is to describe the features of angiosarcoma arising in mucinous tumor that was misinterpreted as a benign vascular proliferation during the intraoperative consultation. A 45-year-old woman presented with an abdominal mass for 1 month. Exploratory laparotomy was performed. A 35 cm right ovarian mass submitted for intraoperative consultation was a multicystic mucinous tumor with an 8 cm area of hemorrhagic lesion between cystic locules...
2016: Case Reports in Pathology
M M Al-Sanea, A Z Abdelazem, B S Park, K H Yoo, T Sim, Y J Kwon, S H Lee
ROS1 is a pivotal transmembrane receptor protein tyrosine kinase which regulates several cellular processes like apoptosis, survival, differentiation, proliferation, cell migration, and transformation. There is increasing evidence supporting that ROS1 plays an important role in different malignancies including glioblastoma, colorectal cancer, gastric adenocarcinoma, inflammatory myofibroblastic tumor, ovarian cancer, angiosarcoma, and non small cell lung cancer; thus, ROS1 has become a potential drug discovery target...
2016: Current Medicinal Chemistry
I Yonezawa, M Waki, Y Tamura, R Onoda, M Narushima, T Ishizuka, S Tajima
Angiosarcoma is a rare and aggressive type of sarcoma, and primary angiosarcoma of the ovary is extremely rare. We report the case of a 29-year-old woman who was diagnosed with ovarian angiosarcoma and possible bone metastases. We treated this patient with a gemcitabine-based regimen as postoperative adjuvant chemotherapy, after which she achieved at least 7 years of progression-free survival, an extremely long duration given the aggressive features of this tumour. We retrospectively performed immunohistochemical analyses and fluorescence in situ hybridization to make a pathology diagnosis and to investigate the tumour features...
December 2014: Current Oncology
P C Wu, C T Yue, S C Huang
The patient presented in this case report was a 45-year-old female, with a Stage IIIA ovarian angiosarcoma combined with mature teratoma, that underwent debulking surgery and achieved complete remission for 11 months after six cycles of MAID chemotherapy (mesna, adriamycin/doxorubicin, ifosfamide, and dacarbazine). Thereafter, she had tumor recurrence with peritoneal seeding and massive pleural effusion; hence she received chemotherapy again. Although she had been undergoing a series of chemotherapies, the tumor continued to progress...
2014: European Journal of Gynaecological Oncology
Rafael Dezen Gaiolla, Ivison Xavier Duarte, Carlos Eduardo Bacchi, Carlos Eduardo Paiva
Angiosarcomas are rare aggressive neoplasms of vascular endothelial origin with a high metastatic rate and poor prognosis. Involvement of the bone marrow by the angiosarcoma is exceedingly uncommon, and there have only been a few cases reported in the literature to date. Clinical manifestations and common laboratory findings of bone marrow involvement can mimic other more common bone marrow-replacing neoplasias such as lymphomas and acute leukemia. A definitive diagnosis is difficult to make from cytologic material, probably due to an associated bone marrow fibrosis, and requires bone marrow trephine biopsy with an immunohistochemical profile...
January 2014: Case Reports in Oncology
Nausheen Yaqoob, Dalal Nemenqani, Hatem Khoja, Moemen Hafez, Asma Tulbah, Fuoad Al-Dayel
INTRODUCTION: Sarcomas of the ovary can either be histologically pure or can represent components of a more complex tumor. Ovarian angiosarcomas are rare, and probably arise from carcinosarcomas, teratomas or the rich ovarian vasculature. To date, only two small case series have been published, one with four cases and the other with seven. CASE PRESENTATION: A 41-year-old Saudi woman presented to our gynecological clinic with abnormal vaginal bleeding. The initial clinical diagnosis was left ovarian cyst...
2014: Journal of Medical Case Reports
Jayson Wang, Cyril Fisher, Khin Thway
Primary de novo angiosarcoma of the breast is an uncommon, aggressive neoplasm. Here, we present a case of a young woman who initially developed primary angiosarcoma of the breast, and subsequently angiosarcoma of the ovary during pregnancy two years later. Only two confirmed primary angiosarcomas of the breast metastasizing specifically to the ovary have been described in the literature. However, all previous cases had ovarian metastases at presentation or shortly after initial diagnosis. This case is unusual as it occurred after a relatively long interval, and apparently developed during pregnancy...
2013: Case Reports in Oncological Medicine
Cassandra Albertin, Karen A Johnson, Joseph P Connor, Ahmed N Al-Niaimi
► Ovarian angiosarcomas are rare and clinically aggressive neoplasms. ► In addition to surgery, taxol is the most studied adjuvant chemotherapy. ► Anti-angiogenic therapies can be considered as an option.
2013: Gynecologic Oncology Case Reports
Stephanie H Guseh, Leslie S Bradford, Lida P Hariri, John O Schorge
No abstract text is available yet for this article.
2012: Gynecologic Oncology Case Reports
Anita Chudecka-Głaz, Janusz Menkiszak, Sławomir Kuźniak, Magdalena Lewandowska, Mirosław Burak, Anna Walecka
Angiosarcoma is a rare form of sarcoma which may be either a primary tumor or it may result from previous irradiation because of another tumor. In this paper, we present a case of a female patient diagnosed as having peritoneal disseminated angiosarcoma 20 years after ovarian cancer treatment (surgery, chemotherapy and radiotherapy). The case was very atypical because of an extremely rare peritoneal location and disseminated nature of the changes. Based on the initial histological picture, poorly differentiated cancer metastasis was diagnosed, suggesting a recurrence of the ovarian cancer that had been diagnosed earlier...
2014: Gynecologic and Obstetric Investigation
Arnold-Jan Kruse, Simone Sep, Brigitte F M Slangen, Nathalie M Vandevijver, Toon Van Gorp, Roy F Kruitwagen, Koen K Van de Vijver
OBJECTIVE: Angiosarcomas are aggressive, malignant soft tissue neoplasms of endothelial origin and occur rarely in the female genital tract. There is lack of consensus on risk factors for poor outcome and optimal treatment. To this end, we performed a clinicopathologic review and survival analysis. METHODS: We report a case of a woman with an angiosarcoma of the vagina. Published English literature was reviewed for angiosarcomas of the vulva, vagina, uterus, and ovary...
January 2014: International Journal of Gynecological Cancer
Michael J Kluk, Todd Ashworth, Hongfang Wang, Birgit Knoechel, Emily F Mason, Elizabeth A Morgan, David Dorfman, Geraldine Pinkus, Oliver Weigert, Jason L Hornick, Lucian R Chirieac, Michelle Hirsch, David J Oh, Andrew P South, Irene M Leigh, Celine Pourreyron, Andrew J Cassidy, Daniel J Deangelo, David M Weinstock, Ian E Krop, Deborah Dillon, Jane E Brock, Alexander J F Lazar, Myron Peto, Raymond J Cho, Alexander Stoeck, Brian B Haines, Sriram Sathayanrayanan, Scott Rodig, Jon C Aster
Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been lacking. Here, we bridge this gap by developing an immunohistochemical (IHC) stain that detects a neoepitope created by the proteolytic cleavage event that activates NOTCH1. Following validation using xenografted cancers and normal tissues with known patterns of NOTCH1 activation, we applied this test to tumors linked to dysregulated Notch signaling by mutational studies...
2013: PloS One
Kurtis D Davies, Robert C Doebele
Genetic alterations that lead to constitutive activation of kinases are frequently observed in cancer. In many cases, the growth and survival of tumor cells rely upon an activated kinase such that inhibition of its activity is an effective anticancer therapy. ROS1 is a receptor tyrosine kinase that has recently been shown to undergo genetic rearrangements in a variety of human cancers, including glioblastoma, non-small cell lung cancer (NSCLC), cholangiocarcinoma, ovarian cancer, gastric adenocarcinoma, colorectal cancer, inflammatory myofibroblastic tumor, angiosarcoma, and epithelioid hemangioendothelioma...
August 1, 2013: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Eleonora Savitchi, Sumati Rao
Malignant transformation of a mature ovarian teratoma is a rare occurrence predominantly in the postmenopausal period. All histologic types can be seen; however, squamous cell carcinoma accounts for over 75% of cases. Sarcomatous transformation is much more uncommon, with cases of angiosarcoma, rhabdomyosarcoma, leiomyosarcoma and liposarcoma arising in a mature ovarian teratoma described in literature. We report a case of squamous cell carcinoma and pleomorphic sarcoma arising in a mature cystic teratoma of the ovary in a 58-year-old woman...
September 2012: International Journal of Gynecological Pathology
Hiroyuki Takahashi, Pattama Chaopotong, Sabine Kajita, Miki Hashimura, Hitoshi Yamazaki, Makoto Saegusa
Malignant transformation of a mature teratoma in the ovary is a rare event, with an approximate rate of only 1-2%. Here, we report an ovarian tumor with a unique combination of epithelial and non-epithelial malignant components, including mature teratoma elements. A 59 year-old postmenopusal woman underwent total hysterectomy and bilateral salpingo-oophorectomy to remove a huge solid mass of the right ovary. The ovarian tumor was 16 × 12 × 4.5 cm in dimensions, composed of red-brown and greyish-white tissue with several cystic areas...
August 2012: Pathology International
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