keyword
MENU ▼
Read by QxMD icon Read
search

lung cancer radiation

keyword
https://www.readbyqxmd.com/read/29028221/quality-of-life-and-patient-reported-outcomes-following-proton-radiation-therapy-a-systematic-review
#1
Vivek Verma, Charles B Simone, Mark V Mishra
Background: As costs of cancer care rise, the importance of documenting value in oncology increases. Proton beam radiotherapy (PBT) has the potential to reduce toxicities in cancer patients, but is relatively expensive and unproven. Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic searches were conducted...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29024929/inhibition-of-microrna-21-5p-promotes-the-radiation-sensitivity-of-non-small-cell-lung-cancer-through-hmsh2
#2
Yu Song, Yun Zuo, Xiao-Lan Qian, Zhi-Peng Chen, Shao-Kai Wang, Lei Song, Li-Ping Peng
BACKGROUND: This study aimed to explore the effects of microRNA-21-5p (miR-21-5p) on the radiation sensitivity of non-small cell lung cancer (NSCLC) and the involvement of human MutS homolog 2 (hMSH2) One hundred fourteen NSCLC patients at stage II or III who received surgery and postoperative radiotherapy were enrolled in this study. METHODS: The patients were assigned into radiation-sensitive and -insensitive groups. NSCLC A549 cells were transfected to generate control, Negative control (NC), miR-21-5p inhibitor, miR-21-5p mimic, small interfering hMSH2 (sihMSH2), miR-21-5p inhibitor + sihMSH2 and hMSH2 overexpression groups...
October 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29024297/reducing-dose-to-the-lungs-through-loosing-target-dose-homogeneity-requirement-for-radiotherapy-of-non-small-cell-lung-cancer
#3
Junjie Miao, Hui Yan, Yuan Tian, Pan Ma, Zhiqiang Liu, Minghui Li, Wenting Ren, Jiayun Chen, Ye Zhang, Jianrong Dai
It is important to minimize lung dose during intensity-modulated radiation therapy (IMRT) of nonsmall cell lung cancer (NSCLC). In this study, an approach was proposed to reduce lung dose by relaxing the constraint of target dose homogeneity during treatment planning of IMRT. Ten NSCLC patients with lung tumor on the right side were selected. The total dose for planning target volume (PTV) was 60 Gy (2 Gy/fraction). For each patient, two IMRT plans with six beams were created in Pinnacle treatment planning system...
October 11, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29017827/subjective-global-assessment-sga-score-could-be-a-predictive-factor-for-radiation-pneumonitis-in-lung-cancer-patients-with-normal-pulmonary-function-treated-by-intensity-modulated-radiation-therapy-and-concurrent-chemotherapy
#4
Li Ma, WenFeng Ye, QiWen Li, Bin Wang, GuangYu Luo, ZhaoLin Chen, SuPing Guo, Bo Qiu, Hui Liu
INTRODUCTION: To investigate the relationship between malnutrition and the severity of radiation pneumonitis (RP) in patients with lung cancer with normal baseline pulmonary function and lungs' V20 < 35% treated by intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy. MATERIALS AND METHODS: A total of 150 patients with lung cancer who received definitive IMRT (≥ 60 Gy) and concurrent chemotherapy were enrolled. In the condition of normal baseline pulmonary function and strict constraints of the irradiation dose to normal lung tissues, we recorded Eastern Cooperative Oncology Group score; concurrent chemotherapy; clinical stage; the level of albumin (ALB), hemoglobin, and C-reactive protein; Subjective Global Assessment (SGA) scores; radiation esophagitis grade; V20 of lungs; and mean lung dose...
September 19, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29016814/early-post-treatment-assessment-of-mri-perfusion-biomarkers-can-predict-long-term-response-of-lung-cancer-brain-metastases-to-stereotactic-radiosurgery
#5
Neil K Taunk, Jung Hun Oh, Amita Shukla-Dave, Kathryn Beal, Behroze Vachha, Andrei Holodny, Vaios Hatzoglou
Background: Imaging criteria to evaluate the response of brain metastases to stereotactic radiosurgery (SRS) in the early post-treatment period remains a crucial unmet need. The aim of this study is to correlate early (within 12 weeks) post-treatment perfusion MRI changes with long-term outcomes after treatment of lung cancer brain metastases with SRS. Methods: Pre- and post-treatment perfusion MRI scans were obtained in patients treated with SRS for intact non-small cell lung cancer brain metastases...
August 24, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28993195/effect-of-trichostatin-a-on-radiation-induced-epithelial-mesenchymal-transition-in-a549%C3%A2-cells
#6
SunilGowda Sunnaghatta Nagaraja, Vishnuvarthan Krishnamoorthy, Raghavi Raviraj, Alagudinesh Paramasivam, Devipriya Nagarajan
Radiotherapy is used to treat tumors of different origins and nature, but often lead to development of radioresistance and metastasis of cells. Interestingly, radiation induces epithelial-mesenchymal transition (EMT), a process by which epithelial cells undergo mesenchymal phenotype and stimulates tumor progression capability. Our study investigated the effect of Trichostatin A (TSA), a natural derivate isolated from Streptomyces, upon radiation-induced lung EMT and we tried to understand the role of signaling molecules in irradiated lung cancer cells (A549)...
October 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28992088/carbon-ion-radiotherapy-for-patients-with-advanced-stage-non-small-cell-lung-cancer-at-multicenters
#7
Masataka Karube, Naoyoshi Yamamoto, Yoshiyuki Shioyama, Junichi Saito, Akira Matsunobu, Tamaki Okimoto, Tatsuya Ohno, Hiroshi Tsuji, Takashi Nakano, Tadashi Kamada
Carbon-ion radiation therapy (CIRT) for advanced non-small-cell lung cancer (NSCLC) has not been well studied to date. This paper aimed to analyze a retrospective multicenter survey for detecting problems with the use of CIRT for Stage II and III NSCLC (7th UICC TNM Staging System). Inclusion was restricted to patients with Stage II and III NSCLC who received CIRT from November 2003 to December 2014. We gathered the data from three CIRT operating centers on July 2015. Patients with radiotherapy history, patients with cancers other than lung cancer, and those receiving palliative therapies were excluded...
July 14, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28991003/site-specific-solid-cancer-mortality-following-exposure-to-ionizing-radiation-a-cohort-study-of-workers-inworks
#8
David B Richardson, Elisabeth Cardis, Robert D Daniels, Michael Gillies, Richard Haylock, Klervi Leuraud, Dominique Laurier, Monika Moissonnier, Mary K Schubauer-Berigan, Isabelle Thierry-Chef, Ausrele Kesminiene
BACKGROUND: There is considerable scientific interest in associations between protracted low-dose exposure to ionizing radiation and the occurrence of specific types of cancer. METHODS: Associations between ionizing radiation and site-specific solid cancer mortality were examined among 308,297 nuclear workers employed in France, the United Kingdom, and the United States. Workers were monitored for external radiation exposure and follow-up encompassed 8.2 million person-years...
October 4, 2017: Epidemiology
https://www.readbyqxmd.com/read/28988893/radiation-therapy-of-synchronous-bilateral-breast-carcinoma-sbbc-using-multiple-techniques
#9
Sung Jin Kim, Mi Jo Lee, Seon Min Youn
The purpose of this study was to establish intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) treatment plans for synchronous bilateral breast cancer (SBBC) and to compare those plans with the previous treatment plans using 3D conformal radiation therapy (3DCRT). The differences among the treatments were also statistically compared regarding dosimetry distribution and treatment efficiency. The research was conducted with 10 SBBC patients. The study established IMRT (12 fields with a single isocenter) and VMAT (2 partial arcs with a single isocenter) treatment plans for SBBC patients and then compared those plans with 3DCRT (8 fields with multiple isocenters)...
October 5, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28988243/efficacy-in-treating-lung-metastasis-of-invasive-breast-cancer-with-functional-vincristine-plus-dasatinib-liposomes
#10
Fan Zeng, Rui-Jun Ju, Lei Liu, Hong-Jun Xie, Li-Min Mu, Wan-Liang Lu
BACKGROUND: The metastasis of breast cancer is the leading cause of death, while lung metastasis is a major clinical phenomenon in patients with invasive breast cancer. The current treatment option comprising surgery, radiation, and standard chemotherapy cannot achieve a satisfactory effect on the treatment of lung metastasis of breast cancer. In this study, we report the potential of preventing lung metastasis of invasive breast cancer using the newly developed functional vincristine plus dasatinib liposomes...
October 7, 2017: Pharmacology
https://www.readbyqxmd.com/read/28985139/lung-cancer-risk-from-plutonium-a-pooled-analysis-of-the-mayak-and-sellafield-worker-cohorts
#11
Michael Gillies, Irina Kuznetsova, Mikhail Sokolnikov, Richard Haylock, Jackie O'Hagan, Yulia Tsareva, Elena Labutina
In this study, lung cancer risk from occupational plutonium exposure was analyzed in a pooled cohort of Mayak and Sellafield workers, two of the most informative cohorts in the world with detailed plutonium urine monitoring programs. The pooled cohort comprised 45,817 workers: 23,443 Sellafield workers first employed during 1947-2002 with follow-up until the end of 2005 and 22,374 Mayak workers first employed during 1948-1982 with follow-up until the end of 2008. In the pooled cohort 1,195 lung cancer deaths were observed (789 Mayak, 406 Sellafield) but only 893 lung cancer incidences (509 Mayak, 384 Sellafield, due to truncated follow-up in the incidence analysis)...
October 6, 2017: Radiation Research
https://www.readbyqxmd.com/read/28983918/how-many-cancer-cases-and-deaths-are-potentially-preventable-estimates-for-australia-in-2013
#12
Louise F Wilson, Annika Antonsson, Adele C Green, Susan J Jordan, Bradley J Kendall, Christina M Nagle, Rachel E Neale, Catherine M Olsen, Penelope M Webb, David C Whiteman
Cancer is a leading cause of disease burden in Australia, particularly fatal burden, accounting for an estimated thirty percent of deaths. Many cancers develop because of exposure to lifestyle and environmental factors that are potentially modifiable. We aimed to quantify the proportions and numbers of cancer deaths and cases in Australia in 2013 attributable to 20 modifiable factors in eight broad groupings that are established causes of cancer, namely: tobacco smoke (smoking and second-hand), dietary factors (low intake of fruit, non-starchy vegetables and dietary fibre; and high intake of red and processed meat), overweight/obesity, alcohol, physical inactivity, solar ultraviolet radiation, infections (seven agents), and reproductive factors (lack of breastfeeding, menopausal hormone therapy use, combined oral contraceptive use)...
October 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28982885/potential-pitfalls-of-a-fiducial-marker-matching-technique-in-carbon-ion-radiotherapy-for-lung-cancer
#13
Shintaro Shiba, Jun-Ichi Saitoh, Daisuke Irie, Katsuyuki Shirai, Takanori Abe, Yoshiki Kubota, Makoto Sakai, Ryosuke Okada, Tatsuya Ohno, Takashi Nakano
BACKGROUND/AIM: To analyze the accuracy of patient positioning and dose distribution quality using a fiducial marker-matching technique in carbon-ion radiotherapy (C-ion RT) for stage I lung cancer. PATIENTS AND METHODS: Thirteen patients with 26 fiducial markers and 104 radiation fields were examined. Change in the fiducial marker position coordinates from the gross tumor volume center (Δm), and change in the water-equivalent path length of the chest wall (ΔWEL) were measured in each radiation field...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28981871/should-we-be-concerned-about-the-doses-of-ionizing-radiation-related-to-diagnostic-and-follow-up-imaging-in-patients-with-solitary-pulmonary-nodules
#14
Marta Dabrowska, Zuzanna Przybylo, Malgorzata Zukowska, Malgorzata Kobylecka, Marta Maskey-Warzechowska, Rafal Krenke
Diagnosing solitary pulmonary nodules (SPNs) frequently requires radiological follow up associated with exposure to ionizing radiation. The aim of this study was to estimate the effective dose of ionizing radiation in patients diagnosed and followed up due to SPNs, which were found beyond lung cancer screening programs. We estimated the exposure to ionizing radiation as effective doses (ED) of all imaging techniques using ionizing radiation: chest computed tomography (CT), contrast enhanced CT (CECT) and positron emission tomography combined with CT (PET/CT) in each patient...
August 5, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28981856/comparative-study-of-radon-exposure-in-canadian-homes-and-uranium-mines-a-discussion-on-the-importance-of-national-radon-program
#15
Jing Chen
The history of lung cancer in uranium miners is well known for over hundreds of years when the disease was referred to as 'miner's disease' or 'mountain sickness'. Radon levels in uranium mines have decreased significantly over the past 30 years as a result of effective radiation protection measures at workplaces. For the most recent 10-year period, the average radon concentrations to underground and surface workers in Canadian uranium mines were 111 and 11 Bq m-3, respectively. Based on the recent radon survey carried out in roughly 14 000 homes in 121 health regions across Canada and the more recent radon and thoron survey in 33 Canadian cities and 4000 homes, the average radon concentration in Canadian homes is 77 Bq m-3...
September 18, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28977826/ilomastat-a-synthetic-inhibitor-of-mmps-prevents-lung-injury-induced-by-%C3%AE-ray-irradiation-in-mice
#16
Xiaoman Li, Dehui Ma, Xiaodan Zha, Dongqin Quan, Dong Pan, Manji Sun, Burong Hu, Baoquan Zhao
Lung injury is one of the pathological features in human or animal after radiation and the main side effect for patient after lung cancer radiotherapy. The efficient protective strategy still needs to exploit and the underlying mechanisms remain to be investigated. We found that the expression and activity of matrix metalloproteinases (MMPs) significantly increased at the early stage of radiation-induced lung injury (RILI). Pretreatment with Ilomastat, a synthetic inhibitor of MMPs, decreased the expression and activity of MMPs and significantly alleviated the lung inflammation and fibrosis in the irradiated mice, as well as enhanced the survival of irradiated mice...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975081/radiotherapy-for-oligometastatic-lung-cancer
#17
REVIEW
Derek P Bergsma, Joseph K Salama, Deepinder P Singh, Steven J Chmura, Michael T Milano
Non-small cell lung cancer (NSCLC) typically presents at an advanced stage, which is often felt to be incurable, and such patients are usually treated with a palliative approach. Accumulating retrospective and prospective clinical evidence, including a recently completed randomized trial, support the existence of an oligometastatic disease state wherein select individuals with advanced NSCLC may experience historically unprecedented prolonged survival with aggressive local treatments, consisting of radiotherapy and/or surgery, to limited sites of metastatic disease...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28974918/high-tangent-radiation-therapy-with-field-in-field-technique-for-breast-cancer
#18
Hidekazu Tanaka, Masaya Ito, Takahiro Yamaguchi, Kae Hachiya, Takahiko Yajima, Masashi Kitahara, Katsuya Matsuyama, Satoshi Goshima, Manabu Futamura, Masayuki Matsuo
PURPOSE: We evaluated whether the field-in-field (FIF) technique improves the homogeneity of the target in high tangent radiation therapy (HTRT). MATERIALS AND METHODS: This study included 30 patients. In total, 3 HTRT plans were created: 1 with conventional opposed fields (Conv-p), 1 with the FIF technique (FIF-p), and 1 with FIF technique using lung-blocked subfields (FIF-LB-p). RESULTS: The maximum dose of the breast and planning target volume (PTV) was significantly lower for FIF-p and FIF-LB-p than Conv-p...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28974856/cardiac-dose-reduction-with-deep-inspiratory-breath-hold-technique-of-radiotherapy-for-left-sided-breast-cancer
#19
Lalitha Kameshwari Sripathi, Parveen Ahlawat, David K Simson, Chira Ranjan Khadanga, Lakshmipathi Kamarsu, Shital Kumar Surana, Kavi Arasu, Harpreet Singh
INTRODUCTION: Different techniques of radiation therapy have been studied to reduce the cardiac dose in left breast cancer. AIM: In this prospective dosimetric study, the doses to heart as well as other organs at risk (OAR) were compared between free-breathing (FB) and deep inspiratory breath hold (DIBH) techniques in intensity modulated radiotherapy (IMRT) and opposed-tangent three-dimensional radiotherapy (3DCRT) plans. MATERIALS AND METHODS: Fifteen patients with left-sided breast cancer underwent computed tomography simulation and images were obtained in both FB and DIBH...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28974415/hypofractionated-stereotactic-radiation-therapy-to-the-resection-bed-for-intracranial-metastases
#20
Audrey Keller, Mélanie Doré, Hélène Cebula, François Thillays, François Proust, Ioana Darié, Stéphane-André Martin, Gregory Delpon, François Lefebvre, Georges Noël, Delphine Antoni
PURPOSE: To retrospectively report the outcomes of a large multicenter cohort of patients treated with surgery and hypofractionated stereotactic radiation therapy (HFSRT) to the resection cavities of brain metastases (BMs). METHODS AND MATERIALS: Between March 2008 and February 2015, 181 patients with no prior whole-brain radiation therapy (WBRT) were treated by HFSRT to the surgical bed of BM at the dose of 33 Gy (3 × 11 Gy). The primary endpoint was local control...
August 19, 2017: International Journal of Radiation Oncology, Biology, Physics
keyword
keyword
37062
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"