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https://www.readbyqxmd.com/read/29452269/progress-in-radiotherapy-for-regional-and-oligometastatic-disease-in-2017
#1
REVIEW
Suresh Senan, Chad G Rusthoven, Ben J Slotman, Shankar Siva
This review highlights key publications and abstracts in the field of radiation oncology for lung cancer in 2017, and attempts to place these in the context of developments for the broader thoracic oncology community.
February 13, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29450843/detection-of-lung-contour-with-closed-principal-curve-and-machine-learning
#2
Tao Peng, Yihuai Wang, Thomas Canhao Xu, Lianmin Shi, Jianwu Jiang, Shilang Zhu
Radiation therapy plays an essential role in the treatment of cancer. In radiation therapy, the ideal radiation doses are delivered to the observed tumor while not affecting neighboring normal tissues. In three-dimensional computed tomography (3D-CT) scans, the contours of tumors and organs-at-risk (OARs) are often manually delineated by radiologists. The task is complicated and time-consuming, and the manually delineated results will be variable from different radiologists. We propose a semi-supervised contour detection algorithm, which firstly uses a few points of region of interest (ROI) as an approximate initialization...
February 15, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29449898/targeted-therapy-of-brain-metastases-latest-evidence-and-clinical-implications
#3
REVIEW
Rodica Di Lorenzo, Manmeet S Ahluwalia
Brain metastases (BM) occur in 20-40% of patients with cancer and 60-75% of patients with BM become symptomatic. Due to an aging population and advances in the treatment of primary cancers, patients are living longer and are more likely to experience complications from BM. The diagnosis of BM drastically worsens long-term survival rates, with multiple metastases being a poor prognostic factor. Until recently, the mainstay of treatment consisted of stereotactic radiosurgery (SRS), surgical resection, whole brain radiation therapy (WBRT), or a combination of these modalities...
December 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29446317/credentialing-of-radiotherapy-centres-in-australasia-for-trog-09-02-chisel-a-phase-iii-clinical-trial-on-stereotactic-ablative-body-radiotherapy-of-early-stage-lung-cancer
#4
Tomas Kron, Brent Chesson, Nicholas Hardcastle, Melissa Crain, Natalie Clements, Mark Burns, David Ball
OBJECTIVE: A randomised clinical trial comparing Stereotactic Ablative Body Radiotherapy (SABR) with conventional radiotherapy for early stage lung cancer has been conducted in Australia and New Zealand under the auspices of the TransTasman Radiation Oncology Group (NCT01014130). We report on the technical credentialing program as prerequisite for centres joining the trial. METHODS: Participating centres were asked to develop treatment plans for two test cases to assess their ability to create plans according to protocol...
February 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29437879/characterizing-the-potency-and-impact-of-carbon-ion-therapy-in-a-primary-mouse-model-of-soft-tissue-sarcoma
#5
Jeremy Michael Brownstein, Amy Jordan Wisdom, Katherine D Castle, Yvonne M Mowery, Peter M Guida, Chang-Lung Lee, Francesco Tommasino, Chiara La Tessa, Emanuele Scifoni, Junheng Gao, Lixia Luo, Lorraine Da Silva Campos, Yan Ma, Nerissa Williams, Sin-Ho Jung, Marco Durante, David G Kirsch
Carbon ion therapy (CIT) offers several potential advantages for treating cancers compared with X-ray and proton radiotherapy including increased biological efficacy and more conformal dosimetry. However, CIT potency has not been characterized in primary tumor animal models. Here, we calculate the relative biological effectiveness (RBE) of carbon ions compared to X-rays in an autochthonous mouse model of soft tissue sarcoma. We used Cre/loxP technology to generate primary sarcomas in KrasLSL-G12D/+; p53fl/fl mice...
February 7, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29436168/feasibility-study-of-individualized-optimal-positioning-selection-for-left-sided-whole-breast-radiotherapy-dibh-or-prone
#6
Hui Lin, Tianyu Liu, Chengyu Shi, Saskia Petillion, Isabelle Kindts, Caroline Weltens, Tom Depuydt, Yulin Song, Ziad Saleh, Xie George Xu, Xiaoli Tang
The deep inspiration breath hold (DIBH) and prone (P) position are two common heart-sparing techniques for external-beam radiation treatment of left-sided breast cancer patients. Clinicians select the position that is deemed to be better for tissue sparing based on their experience. This approach, however, is not always optimum and consistent. In response to this, we develop a quantitative tool that predicts the optimal positioning for the sake of organs at risk (OAR) sparing. Sixteen left-sided breast cancer patients were considered in the study, each received CT scans in the supine free breathing, supine DIBH, and prone positions...
February 13, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29436163/using-geud-based-plan-analysis-method-to-evaluate-proton-vs-photon-plans-for-lung-cancer-radiation-therapy
#7
Zhiyan Xiao, Wei J Zou, Ting Chen, Ning J Yue, Salma K Jabbour, Rahul Parikh, Miao Zhang
The goal of this study was to exam the efficacy of current DVH based clinical guidelines draw from photon experience for lung cancer radiation therapy on proton therapy. Comparison proton plans and IMRT plans were generated for 10 lung patients treated in our proton facility. A gEUD based plan evaluation method was developed for plan evaluation. This evaluation method used normal lung gEUD(a) curve in which the model parameter "a" was sampled from the literature reported value. For all patients, the proton plans delivered lower normal lung V5 Gy with similar V20 Gy and similar target coverage...
February 13, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29434986/association-between-clinicopathological-factors-and-postoperative-radiotherapy-in-patients-with-completely-resected-pathological-n2-non-small-cell-lung-cancer
#8
Yujin Xu, Jianqiang Li, Jin Wang, Xiao Hu, Honglian Ma, Pu Li, Xiao Zheng, Ming Chen
The function of postoperative radiotherapy (PORT) in patients with completely resected pathologically N2 (pN2) non-small cell lung cancer (NSCLC) remains controversial due to a lack of prospective studies. The present study aimed to evaluate the efficacy of PORT in completely resected pN2 NSCLC when using modern radiation techniques, and to determine the associations between clinicopathological factors and PORT and survival rates. Following patient selection, 246 out of 269 consecutive patients with pN2 NSCLC were enrolled in the present study, with 88 patients having received postoperative chemotherapy (POCT) and PORT, 90 having received adjuvant chemotherapy, 1 having received adjuvant radiotherapy and the remaining 67 having received no adjuvant therapy...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433891/survival-after-radiation-for-stage-i-and-ii-non-small-cell-lung-cancer-with-positive-margins
#9
Brian C Gulack, Morgan L Cox, Chi-Fu Jeffrey Yang, Paul J Speicher, H Volkan Kara, Thomas A D'Amico, Mark F Berry, Matthew G Hartwig
BACKGROUND: There is limited data guiding treatment for positive margins following lobectomy for early-stage non-small cell lung cancer (NSCLC). Using data from the National Cancer Data Base, we sought to determine whether radiation therapy following lobectomy for stage I or II NSCLC was associated with improved overall survival in patients with positive margins. METHODS: Patients who underwent lobectomy without induction therapy for stage I or II NSCLC (1998-2006) with positive resection margins were selected...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433723/reviewing-lung-cancer-screening-the-who-where-when-why-and-how
#10
REVIEW
Brett C Bade, Paul B Brasher, Branden W Luna, Gerard A Silvestri, Nichole T Tanner
Lung cancer screening with annual low-dose computed tomography (CT) decreases lung cancer mortality in high-risk patients, as defined by smoking history (> 30 pack-years) and age (55-74 years). Risks to screening include overdiagnosis, anxiety about indeterminate nodules, and radiation exposure. To be effective, lung cancer screening must combine individualized risk assessment, shared decision-making, smoking cessation, structured reporting, high quality and multi-specialty cancer care, and reliable follow-up; a multidisciplinary approach is crucial...
March 2018: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29430654/enhanced-efficacy-of-azd3759-and-radiation-on-brain-metastasis-from-egfr-mutant-non-small-cell-lung-cancer
#11
Xue Li, Yingchun Wang, Jia Wang, Tianwei Zhang, Li Zheng, Zhenfan Yang, Ligang Xing, Jinming Yu
The prognosis of patients with brain metastasis (BM) is poor. In this study, we demonstrated that AZD3759, an EGFR tyrosine kinase inhibitors (TKIs) with excellent blood-brain barrier (BBB) penetration, combined with radiation enhanced the antitumor efficacy in BM model from EGFR mutant (EGFRm) NSCLC. Besides, the antitumor activity displayed no difference between radiation concurrently with AZD3759 and radiation sequentially with AZD3759. Mechanistically, we found that two factors determined the enhanced efficacy: cells with EGFRm which were sensitive to AZD3759, and a relative high concentration of AZD3759...
February 12, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29429888/risk-factors-for-local-recurrence-after-total-en-bloc-spondylectomy-for-metastatic-spinal-tumors-a-retrospective-study
#12
Takashi Igarashi, Hideki Murakami, Satoru Demura, Satoshi Kato, Katsuhito Yoshioka, Noriaki Yokogawa, Hiroyuki Tsuchiya
BACKGROUND: The aim of this study was to evaluate local recurrence and survival outcomes after frozen autograft total en bloc spondylectomy for metastatic spinal tumors. METHODS: We retrospectively analyzed data from 91 patients with metastatic spinal tumors who underwent frozen autograft total en bloc spondylectomy at our institution between May 2010 and April 2015. We assessed the incidence, primary cancer type, and sites of local recurrence. Risk factors for local recurrence were also examined through the statistical analysis of 17 items, including clinico-pathological characteristics, treatment history, and preoperative or surgical complications...
February 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29420619/a-national-survey-of-lung-cancer-specialists-views-on-low-dose-ct-screening-for-lung-cancer-in-korea
#13
Dong Wook Shin, Sohyun Chun, Young Il Kim, Seung Joon Kim, Jung Soo Kim, SeMin Chong, Young Sik Park, Sang-Yun Song, Jin Han Lee, Hee Kyung Ahn, Eun Young Kim, Sei Hoon Yang, Myoung Kyu Lee, Deog Gon Cho, Tae Won Jang, Ji Woong Son, Jeong-Seon Ryu, Moon-June Cho
Lung cancer specialists play an important role in designing and implementing lung cancer screening. We aimed to describe their 1) attitudes toward low-dose lung computed tomography (LDCT) screening, 2) current practices and experiences of LDCT screening and 3) attitudes and opinions towards national lung cancer screening program (NLCSP). We conducted a national web-based survey of pulmonologists, thoracic surgeons, medical oncologists, and radiological oncologists who are members of Korean Association for Lung Cancer (N = 183)...
2018: PloS One
https://www.readbyqxmd.com/read/29417293/enhancing-evaluation-of-sarcopenia-in-patients-with-non-small-cell-lung-cancer-nsclc-by-assessing-skeletal-muscle-index-smi-at-the-first-lumbar-l1-level-on-routine-chest-computed-tomography-ct
#14
Alejandro Recio-Boiles, Jose N Galeas, Bernard Goldwasser, Karla Sanchez, Louise M W Man, Ryan D Gentzler, Jane Gildersleeve, Patricia J Hollen, Richard J Gralla
PURPOSE: Ongoing cancer cachexia trials evaluate sarcopenia by skeletal muscle index (SMI) at the L3 vertebrae level, commonly used as a standard. Routine chest CT institutional protocols widely differ in including L3. We investigated whether SMI at L1 assessment, rather than L3, would be reliable and more practicable for non-small cell lung cancer (NSCLC). METHODS: NSCLC patients with routine CT chest had SMI measurements performed at L1 using Slice-O-Matic software...
February 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29416669/association-of-dna-repair-gene-polymorphisms-with-the-risk-of-radiation-pneumonitis-in-lung-cancer-patients
#15
Lehui Du, Wei Yu, Xiangkun Dai, Nana Zhao, Xiang Huang, Fang Tong, Fang Liu, Yurong Huang, Zhongjian Ju, Wei Yang, Xiaohu Cong, Chuanbin Xie, Xiaoliang Liu, Lanqing Liang, Yanan Han, Baolin Qu
A total of 149 lung cancer patients were recruited to receive intensity modulated radiation therapy (IMRT). The association of developing radiation pneumonitis (RP) with genetic polymorphism was evaluated. The risks of four polymorphic sites in three DNA repair related genes (ERCC1, rs116615:T354C and rs3212986:C1516A; ERCC2, rs13181:A2251C; XRCC1, rs25487:A1196G) for developing grade ≥ 2 RP were assessed respectively. It was observed that ERCC1 T354C SNP had a significant effect on the development of grade ≥ 2 RP (CT/TT vs...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415179/incidence-of-organizing-pneumonia-after-whole-breast-radiotherapy-for-breast-cancer-and-risk-factor-analysis
#16
Hisashi Sato, Junko Ebi, Tomoaki Tamaki, Ami Yukawa, Masaru Nakajima, Tohru Ohtake, Yoshiyuki Suzuki
Radiation-induced organizing pneumonia (OP) reportedly occurs in ~2% of patients who receive whole-breast radiotherapy (WBRT). Though there are several reported risk factors, they remain unclear and controversial. We analyzed the incidence of and risk factors for OP after WBRT at our institution. We analyzed 665 breast cancer patients (with WBRT of 679 breasts) who underwent WBRT from October 2007 to September 2012 at our institution and were followed up for more than 1 year after completion of WBRT. Factors included in the analysis were age, the side affected, central lung distance (CLD), radiation dose, concurrent endocrine therapy, and chemotherapy...
February 3, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29414878/histone-deacetylase-inhibitor-induced-radiation-sensitization-effects-on-human-cancer-cells-after-photon-and-hadron-radiation-exposure
#17
Ariungerel Gerelchuluun, Junko Maeda, Eri Manabe, Colleen A Brents, Takeji Sakae, Akira Fujimori, David J Chen, Koji Tsuboi, Takamitsu A Kato
Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor, which has been widely utilized throughout the cancer research field. SAHA-induced radiosensitization in normal human fibroblasts AG1522 and lung carcinoma cells A549 were evaluated with a combination of γ-rays, proton, and carbon ion exposure. Growth delay was observed in both cell lines during SAHA treatment; 2 μM SAHA treatment decreased clonogenicity and induced cell cycle block in G1 phase but 0.2 μM SAHA treatment did not show either of them...
February 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29413287/parp-inhibition-combined-with-thoracic-irradiation-exacerbates-esophageal-and-skin-toxicity-in-c57bl6-mice
#18
Luiza Madia Lourenco, Yanyan Jiang, Neele Drobnitzky, Marcus Green, Fiona Cahill, Agata Patel, Yasmin Shanneik, John Moore, Anderson J Ryan
PURPOSE: Poly (ADP-ribose) polymerase (PARP) inhibitors have been shown to enhance the radiosensitivity of cancer cells in vitro in a replication-dependent manner. Their in vivo radiosensitizing effects have also been demonstrated in preclinical tumor models. However, whether PARP inhibition can enhance the response to radiation therapy in normal tissues has been largely neglected. We hypothesized that PARP inhibition might also potentiate the response of replicating normal tissues to radiation therapy...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29413286/radiation-dose-to-the-thoracic-vertebral-bodies-is-associated-with-acute-hematologic-toxicities-in-patients-receiving-concurrent-chemoradiation-for-lung-cancer-results-of-a-single-center-retrospective-analysis
#19
Christian L Barney, Nicholas Scoville, Eric Allan, Ahmet Ayan, Dominic DiCostanzo, Karl E Haglund, John Grecula, Terence Williams, Meng Xu-Welliver, Gregory A Otterson, Jose G Bazan
PURPOSE: To test the hypothesis that increasing radiation therapy (RT) dose to the thoracic vertebral bodies (TVBs) contributes to the development of hematologic toxicities (HTs) in patients with lung cancer. METHODS AND MATERIALS: Cases of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) treated with definitive chemoradiation with concurrent platinum-based doublet chemotherapy at our institution from 2007 to 2016 were identified. Mean TVB dose and the volume of TVBs receiving at least 5 to 60 Gy (V5-V60) were retrospectively recorded...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29412104/radiation-induced-pulmonary-epithelial-mesenchymal-transition-a-review-of-targeting-molecular-pathways-and-mediators
#20
S N Sunilgowda, Devipriya Nagarajan, Devipriya Nagarajan
Radiotherapy is the most widely used treatment method for average and advanced lung cancer patients. Moreover, the clinical toxicities caused by radiotherapy are categorized into acute radiation pneumonitis and late pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) is a complex physiological process involves many signaling molecules and proteins like adaptor proteins, and transcriptional factors. It was identified as a significant mechanism for fibrosis, wound healing and also cancer. A variety of biomarkers have appeared in radiation-induced lung EMT, some of which are acquired (N-cadherin, vimentin and fibronectin, etc...
February 6, 2018: Current Drug Targets
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