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https://www.readbyqxmd.com/read/29473902/advances-in-residential-design-related-to-the-influence-of-geomagnetism
#1
Francisco Glaria, Israel Arnedo, Ana Sánchez-Ostiz
Since the origin of the Modern Movement, there has been a basic commitment to improving housing conditions and the well-being of occupants, especially given the prediction that 2/3 of humanity will reside in cities by 2050. Moreover, a compact model of the city with tall buildings and urban densification at this scale will be generated. Continuous constructive and technological advances have developed solid foundations on safety, energy efficiency, habitability, and sustainability in housing design. However, studies on improving the quality of life in these areas continue to be a challenge for architects and engineers...
February 23, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29472310/temozolomide-plus-bevacizumab-in-elderly-patients-with-newly-diagnosed-glioblastoma-and-poor-performance-status-an-anocef-phase-ii-trial-atag
#2
Germán Reyes-Botero, Stéphanie Cartalat-Carel, Olivier L Chinot, Maryline Barrie, Luc Taillandier, Patrick Beauchesne, Isabelle Catry-Thomas, Jérôme Barrière, Jean-Sebastien Guillamo, Michel Fabbro, Didier Frappaz, Alexandra Benouaich-Amiel, Emilie Le Rhun, Chantal Campello, Isabelle Tennevet, François Ghiringhelli, Marie-Laure Tanguy, Karima Mokhtari, Jérôme Honnorat, Jean-Yves Delattre
LESSONS LEARNED: Results suggest that the combination of bevacizumab plus temozolomide is active in terms of response rate, survival, performance, quality of life, and cognition in elderly patients with glioblastoma multiforme with poor performance status.Whether this combination is superior to temozolomide alone remains to be demonstrated by a randomized study. BACKGROUND: The optimal treatment of glioblastoma multiforme (GBM) in patients aged ≥70 years with a Karnofsky performance status (KPS) <70 is not established...
February 22, 2018: Oncologist
https://www.readbyqxmd.com/read/29472143/safety-of-vaginal-mesh-surgery-versus-laparoscopic-mesh-sacropexy-for-cystocele-repair-results-of-the-prosthetic-pelvic-floor-repair-randomized-controlled-trial
#3
Jean-Philippe Lucot, Michel Cosson, Georges Bader, Philippe Debodinance, Cherif Akladios, Delphine Salet-Lizée, Patrick Delporte, Denis Savary, Philippe Ferry, Xavier Deffieux, Sandrine Campagne-Loiseau, Renaud de Tayrac, Sébastien Blanc, Sandrine Fournet, Arnaud Wattiez, Richard Villet, Marion Ravit, Bernard Jacquetin, Xavier Fritel, Arnaud Fauconnier
BACKGROUND: Laparoscopic mesh sacropexy (LS) or transvaginal mesh repair (TVM) are surgical techniques used to treat cystoceles. Health authorities have highlighted the need for comparative studies to evaluate the safety of surgeries with meshes. OBJECTIVE: To compare the rate of complications, and functional and anatomical outcomes between LS and TVM. DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized controlled trial from October 2012 to April 2014 in 11 French public hospitals...
February 19, 2018: European Urology
https://www.readbyqxmd.com/read/29472119/dupilumab-treatment-in-moderate-to-severe-atopic-dermatitis-a-systematic-review-and-meta-analysis
#4
Fa-Ping Wang, Xiao-Ju Tang, Chuan-Qi Wei, Lin-Rui Xu, Hui Mao, Feng-Ming Luo
BACKGROUND: Dupilumab, a fully human monoclonal antibody against the interleukin-4-receptor α subunit, has been developed and used in clinical trials to treat atopic dermatitis (AD). OBJECTIVE: We aimed to assess the overall efficacy and safety of dupilumab treatment in AD. METHODS: PubMed, Embase, Cochrane library databases, and the Chinese Biological Medicine (CBM) published up to September 2017 were searched. All randomized controlled trials (RCTs) of dupilumab treatment on adult patients with AD were included...
February 19, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29471919/dupilumab-a-review-of-its-use-in-the-treatment-of-atopic-dermatitis
#5
Melinda J Gooderham, H Chih-Ho Hong, Panteha Eshtiaghi, Kim A Papp
Atopic dermatitis (AD) is a chronic, pruritic immune-mediated inflammatory dermatosis characterized by a T helper 2 (Th2) immune response phenotype and may be associated with systemic inflammation. Dupilumab is an interleukin 4 (IL-4) receptor α-antagonist that inhibits IL-4 and IL-13 signaling through blockade of the shared IL-4α subunit. Blockade of IL-4/13 is effective in reducing Th2 response. Dupilumab has recently been approved in the United States and Europe for the treatment of adult patients with moderate-to-severe AD...
March 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29471685/bronchial-thermoplasty-as-a-treatment-for-severe-asthma-controversies-progress-and-uncertainties
#6
Neil C Thomson
Bronchial thermoplasty is a licensed non-pharmacological treatment for severe asthma. Area covered: This article considers evidence for the efficacy and safety of bronchial thermoplasty from clinical trials and observational studies in clinical practice. Its place in the management of severe asthma, predictors of response and mechanisms of action are reviewed. Expert commentary: Bronchial thermoplasty improves quality of life and reduces exacerbations in moderate to severe asthma. Morbidity from asthma is increased during treatment...
February 23, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29471124/methods-and-procedures-for-a-randomized-double-blind-study-investigating-dose-dependent-longitudinal-effects-of-vitamin-d-supplementation-on-bone-health
#7
Lauren A Burt, Sharon Gaudet, Michelle Kan, Marianne S Rose, Emma O Billington, Steven K Boyd, David A Hanley
The optimum dose of vitamin D and corresponding serum 25-hydroxyvitamin D (25OHD) concentration for bone health is still debated and some health practitioners are recommending doses well above the Canada/USA recommended Dietary Reference Intake (DRI). We designed a three-year randomized double-blind clinical trial investigating whether there are dose-dependent effects of vitamin D supplementation above the Dietary Reference Intake (DRI) on bone health. The primary aims of this study are to assess, whether supplementation of vitamin D3 increases 1) volumetric bone mineral density measured by high-resolution peripheral quantitative computed tomography (HR-pQCT); 2) bone strength assessed by finite element analysis, and 3) areal bone mineral density by dual X-ray absorptiometry (DXA)...
February 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29471035/how-safe-is-the-safety-net-comparison-of-ivor-lewis-esophagectomy-at-a-safety-net-hospital-using-the-nsqip-database
#8
Lori A Gurien, Joseph J Tepas, D Scott Lind, David J Chesire, Michel J Sabra, Brian Ga Dalton, Ziad T Awad
BACKGROUND: Recent data suggest that surgical outcomes at hospitals caring for low-income, vulnerable populations are suboptimal compared to non safety net hospitals. Therefore, the purpose of our study was to compare outcomes for patients who underwent an Ivor-Lewis esophagectomy at a safety net hospital with the National Surgical Quality Improvement Program (NSQIP) database. STUDY DESIGN: We retrospectively reviewed the medical records of consecutive patients who underwent an Ivor-Lewis esophagectomy from September 2013 to January 2017 at a single safety net hospital...
January 21, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29470382/a-tool-to-identify-key-behaviors-and-attributes-of-high-performing-nurses
#9
Linda B Cain, Sherill Nones Cronin, Debbie Nelson, Darla A Meredith, Karen Profitt Newman, Steven Rudolf
OBJECTIVE: The purpose of this project was to identify key behaviors and attributes that distinguish high-performing nurses to develop a tool for employment screening, staff development, and performance management. BACKGROUND: Selecting nurses who will complement an organization's mission and philosophy is a key step toward achieving quality and safety goals, ensuring patient and family satisfaction, and improving retention rates and overall costs. METHODS: Focus group methodology was used to determine perceptions of high-performing nurses' behaviors and attributes...
February 21, 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29470008/quality-assessment-and-performance-improvement-oversight-for-patient-safety
#10
Tracy Givens
No abstract text is available yet for this article.
January 2018: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29469799/complete-response-of-secukinumab-in-palmoplantar-psoriasis
#11
Vicenç Rocamora, Joan Garcías-Ladaria
Palmoplantar psoriasis is plaque psoriasis involving the palms and soles. Palmoplantar psoriasis is a treatment challenge for dermatologists and it is difficult to treat with topical and systemic therapies. Owing to its location and manifestations, palmoplantar psoriasis is associated with greater pain, functional limitations, and significant impairment of health-related quality of life. Recently a new biologic agent, secukinumab, has been approved for treatment of moderate to severe plaque psoriasis. GESTURE trial is a study of the secukinumab clinical development that evaluates efficacy and safety in this subpopulation of patients...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468259/palliative-care-in-heart-failure-a-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
K Zhou, Y Mao
BACKGROUND: Palliative care can play an important role in the management of heart failure. We conducted a systematic review and meta-analysis to compare the efficacy and safety of palliative care in patients with heart failure. METHODS: PubMed, Embase, Web of Science, EBSCO, and the Cochrane Library databases were systematically searched. Randomized controlled trials (RCTs) on the impact of palliative care on heart failure were included. Two investigators independently searched the articles, extracted data, and assessed the quality of included studies...
February 21, 2018: Herz
https://www.readbyqxmd.com/read/29468091/surgical-technical-evidence-review-for-elective-total-joint-replacement-conducted-for-the-ahrq-safety-program-for-improving-surgical-care-and-recovery
#13
REVIEW
Christopher P Childers, Anaar E Siletz, Emily S Singer, Claire Faltermeier, Q Lina Hu, Clifford Y Ko, Gregory J Golladay, Stephen L Kates, Elizabeth C Wick, Melinda Maggard-Gibbons
Background: Use of enhanced recovery pathways (ERPs) can improve patient outcomes, yet national implementation of these pathways remains low. The Agency for Healthcare Research and Quality (AHRQ; funder), the American College of Surgeons, and the Johns Hopkins Medicine Armstrong Institute for Patent Safety and Quality have developed the Safety Program for Improving Surgical Care and Recovery-a national effort to catalyze implementation of practices to improve perioperative care and enhance recovery of surgical patients...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29468084/a-development-study-and-randomised-feasibility-trial-of-a-tailored-intervention-to-improve-activity-and-reduce-falls-in-older-adults-with-mild-cognitive-impairment-and-mild-dementia
#14
Rowan H Harwood, Veronika van der Wardt, Sarah E Goldberg, Fiona Kearney, Pip Logan, Vicky Hood-Moore, Vicky Booth, Jennie E Hancox, Tahir Masud, Zoe Hoare, Andrew Brand, Rhiannon Tudor Edwards, Carys Jones, Roshan das Nair, Kristian Pollock, Maureen Godfrey, John R F Gladman, Kavita Vedhara, Helen Smith, Martin Orrell
Background: People with dementia progressively lose abilities and are prone to falling. Exercise- and activity-based interventions hold the prospect of increasing abilities, reducing falls, and slowing decline in cognition. Current falls prevention approaches are poorly suited to people with dementia, however, and are of uncertain effectiveness. We used multiple sources, and a co-production approach, to develop a new intervention, which we will evaluate in a feasibility randomised controlled trial (RCT), with embedded adherence, process and economic analyses...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29468053/apsic-guidelines-for-disinfection-and-sterilization-of-instruments-in-health-care-facilities
#15
Moi Lin Ling, Patricia Ching, Ammar Widitaputra, Alison Stewart, Nanthipha Sirijindadirat, Le Thi Anh Thu
Background: The Asia Pacific Society of Infection Control launched its revised Guidelines for Disinfection and Sterilization of Instruments in Health Care Facilities in February 2017. This document describes the guidelines and recommendations for the reprocessing of instruments in healthcare setting. It aims to highlight practical recommendations in a concise format designed to assist healthcare facilities at Asia Pacific region in achieving high standards in sterilization and disinfection...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29465598/tuina-for-osteoporosis-a-systematic-review-protocol
#16
Youkang Dong, Rong Zhao, Chunlin Wang, Taipin Guo
BACKGROUND: Osteoporosis is one kind of commonly and frequently occurring global disease accompanying with serious complications. As a branch of the subject of Acupuncture-Tuina, tuina is widely applied for osteoporosis alone or combined with other methods in China and other nations while its effective evidence is not clear. Hence, this systematic review protocol purpose is to evaluate the value of its efficacy and safety for osteoporosis. METHODS: This systematic review and meta-analysis will be performed by means of electronic databases including Cochrane Library, Medline, Cochrane Library, Web of Science, EBASE, Springer, WHO International Clinical Trials Registry Platform (ICTRP), China National Knowledge Infrastructure (CNKI), Wanfang database, Chinese Biomedical Literature Database (CBM), Chinese Scientific Journal Database (VIP) and others with valid search strategy probably...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465566/acupuncture-for-adults-with-overactive-bladder-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Yuwei Zhao, Jing Zhou, Qian Mo, Yang Wang, Jinna Yu, Zhishun Liu
BACKGROUND: Overactive bladder is stated as the occurrence of urinary urgency which will cause negative impacts and decrease patients' health-related quality of life. The aim of this systematic review is to assess the efficiency and safety of acupuncture for adults with overactive bladder (OAB) comparing with sham-acupuncture, drugs, and acupuncture plus drugs. METHODS: We independently searched 9 databases from beginning to August 15, 2017. Two writers extracted data at the same time independently...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465559/cardiac-rehabilitation-in-acute-myocardial-infarction-patients-after-percutaneous-coronary-intervention-a-community-based-study
#18
Yong Zhang, HongXia Cao, Pin Jiang, HaiQin Tang
BACKGROUND: Acute myocardial infarction (AMI) is one of the leading causes of death and physical disability worldwide. However, the development of community- based cardiac rehabilitation (CR) in AMI patients is hysteretic. Here, we aimed to evaluate the safety and efficacy of CR applied in the community in AMI patients who underwent percutaneous coronary intervention (PCI). METHODS: A total of 130 ST-segment elevated myocardial infarction (STEMI) patients after PCI were randomly divided into 2 groups in the community, rehabilitation group (n = 65) and control group (n = 65)...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465496/a-systematic-review-of-exercise-training-in-patients-with-cardiac-implantable-devices
#19
Afnan Hamad Alswyan, Ana Carolina Sauer Liberato, Cynthia M Dougherty
PURPOSE: This systematic review identified exercise-based intervention studies in patients with cardiac implantable devices (CIDs): implantable cardioverter defibrillator (ICD), cardiac resynchronization pacemaker or defibrillator (cardiac resynchronization therapy [CRT]), or ventricular assist device (VAD) and assessed evidence for the safety and efficacy of exercise-based interventions alone or in combination with psychoeducational components. METHODS: PubMed, EMBASE, CINAHL Plus, Web of Science, Cochrane, and PEDro databases were searched from database inception to September 2016...
March 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29465457/key-components-of-the-safe-surgical-ward-international-delphi-consensus-study-to-identify-factors-for-quality-assessment-and-service-improvement
#20
Yasmin A M Hassen, Maximilian J Johnston, Pritam Singh, Philip H Pucher, Ara Darzi
OBJECTIVE: The aim of this study was to prioritize key factors contributing to safety on the surgical ward BACKGROUND:: There is a variation in the quality and safety of postoperative care between institutions. These variations may be attributed to a combination of process-related issues and structural factors. The aim of this study is to reach a consensus, by means of Delphi methodology, on the most influential of these components that may determine safety in this environment. METHODS: The Delphi questionnaire was delivered via an online questionnaire platform...
February 20, 2018: Annals of Surgery
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