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https://www.readbyqxmd.com/read/28097056/rhea-a-transparent-and-modular-r-pipeline-for-microbial-profiling-based-on-16s-rrna-gene-amplicons
#1
Ilias Lagkouvardos, Sandra Fischer, Neeraj Kumar, Thomas Clavel
The importance of 16S rRNA gene amplicon profiles for understanding the influence of microbes in a variety of environments coupled with the steep reduction in sequencing costs led to a surge of microbial sequencing projects. The expanding crowd of scientists and clinicians wanting to make use of sequencing datasets can choose among a range of multipurpose software platforms, the use of which can be intimidating for non-expert users. Among available pipeline options for high-throughput 16S rRNA gene analysis, the R programming language and software environment for statistical computing stands out for its power and increased flexibility, and the possibility to adhere to most recent best practices and to adjust to individual project needs...
2017: PeerJ
https://www.readbyqxmd.com/read/28080097/correction-to-elliott-and-leach-2016
#2
(no author information available yet)
Reports an error in "You must be lying because I don't understand you: Language proficiency and lie detection" by Elizabeth Elliott and Amy-May Leach (Journal of Experimental Psychology: Applied, 2016[Dec], Vol 22[4], 488-499). (The following abstract of the original article appeared in record 2016-59419-006.) We examined the impact of interviewees' language proficiencies on observers' lie detection performance. Observers (N = 132) were randomly assigned to make deception judgments about interviewees (N = 56) from Four proficiency groups (i...
January 12, 2017: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/28064547/a-systematic-approach-to-autoinflammatory-syndromes-a-spelling-booklet-for-the-beginner
#3
Donato Rigante
Hallmark of autoinflammatory syndromes (AIS) is the periodic recurrence of "sterile" inflammatory attacks characterized by fever and organ- or tissue-specific inflammation. Basic research projects over the last two decades have boosted our understanding of pathological pathways, mainly involving interleukin (IL)-1 biosynthesis, and also revealed that their dysregulation results from genetically-heterogeneous inborn errors of innate immunity and leads to multiple inflammatory phenotypes. Starting from the evidence of poor response to IL-1 inhibitors of some patients with multi-organ inflammation, further research studies have disclosed a crucial role for nuclear factor (NF)-κB and type I interferon (IFN) in specific AIS...
January 9, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28047592/su-g-tep1-07-investigation-of-rapidplan-based-plan-quality-for-breast-imrtsimultaneously-integrated-boost
#4
J Wang, W Hu, X Chen, Z Wu
PURPOSE: The aim of this study is to investigate the feasibility of using RapidPlan for breast cancer radiotherapy and to evaluate its performance for planners with different planning experiences. METHODS: A training database was collected with 80 expert plan datasets from patients previously received left breast conserving surgery and IMRT-simultaneously integrated boost radiotherapy. The models were created on the RapidPlan. Five patients from the training database and 5 external patients were used for internal and external validation, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28005009/computer-aided-classification-of-gastrointestinal-lesions-in-regular-colonoscopy
#5
Pablo Mesejo, Daniel Pizarro, Armand Abergel, Olivier Rouquette, Sylvain Beorchia, Laurent Poincloux, Adrien Bartoli
We have developed a technique to study how good computers can be at diagnosing gastrointestinal lesions from regular (white light and narrow banded) colonoscopic videos compared to two levels of clinical knowledge (expert and beginner). Our technique includes a novel tissue classification approach which may save clinician's time by avoiding chromoendoscopy, a time-consuming staining procedure using indigo carmine. Our technique also discriminates the severity of individual lesions in patients with many polyps, so that the gastroenterologist can directly focus on those requiring polypectomy...
September 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27993481/examining-state-health-agency-epidemiologists-and-their-training-needs
#6
Theresa Chapple-McGruder, Jonathon P Leider, Angela J Beck, Brian C Castrucci, Elizabeth Harper, Katie Sellers, Jessica Arrazola, Jeff Engel
PURPOSE: Despite increases in formal education, changing trends affecting epidemiologic practice prompted concerns over whether epidemiologists had sufficient training. METHODS: This study sought to explain factors that predicted low self-reported proficiency levels among daily important work tasks of state health agencies' epidemiologists. The number of knowledge gaps, instances where epidemiologists identified a work-related task both as 'very' important in their daily work and felt they were "unable to perform" or performed at a "beginner" level, was studied, and predictor variables were assessed...
November 29, 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27992277/e-health-in-palliative-care-what-do-research-beginners-need-to-know
#7
Sara Pinto, Sílvia Caldeira, José Carlos Martins
No abstract text is available yet for this article.
December 2016: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/27989272/the-international-society-for-extracellular-vesicles-launches-the-first-massive-open-online-course-on-extracellular-vesicles
#8
EDITORIAL
Cecilia Lässer, Clotilde Théry, Edit I Buzás, Suresh Mathivanan, Weian Zhao, Yong Song Gho, Jan Lötvall
The International Society for Extracellular Vesicles (ISEV) has organised its first educational online course for students and beginners in the field of extracellular vesicles (EVs). This course, "Basics of Extracellular Vesicles," uses recorded lectures from experts in the field and will be open for an unlimited number of participants. The course is divided into 5 modules and can be accessed at www.coursera.org/learn/extracellular-vesicles. The first module is an introduction to the field covering the nomenclature and history of EVs...
2016: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/27984417/association-between-age-of-beginning-primary-school-and-attention-deficit-hyperactivity-disorder
#9
Sebla Gökçe, Yanki Yazgan, Ayşe Burcu Ayaz, Esengül Kayan, Canan Yusufoğlu, Gresa Carkaxhiu Bulut, Herdem Aslan Genç, Ceyda Dedeoğlu, Seçil Demirhan, Arzu Sancak, Gökçe Elif Saridoğan
OBJECTIVE: In April 2012, the Turkish national education system was modified, and the compulsory school age of entry (first grade) was redefined as a minimum of 60 months and a maximum of 66 months (replacing the former minimum criterion of 72 months). In this study, we hypothesized that students starting school before 72 months (the previous age standard for the first grade) may experience (1) a greater number of symptoms of attention deficit hyperactivity disorder (ADHD) and (2) lower functioning in social, behavioral, and academic domains...
January 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27975220/visualization-inspection-and-interpretation-of-shotgun-proteomics-identification-results
#10
Ragnhild R Lereim, Eystein Oveland, Frode S Berven, Marc Vaudel, Harald Barsnes
Shotgun proteomics is a high throughput technique for protein identification able to identify up to several thousand proteins from a single sample. In order to make sense of this large amount of data, proteomics analysis software is needed, aimed at making the data intuitively accessible to beginners as well as experienced scientists. This chapter provides insight on where to start when analyzing shotgun proteomics data, with a focus on explaining the most common pitfalls in protein identification analysis and how to avoid them...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27975214/improving-proteome-coverage-by-reducing-sample-complexity-via-chromatography
#11
Uma Kota, Mark L Stolowitz
High performance liquid chromatography (HPLC) is currently one of the most powerful analytical tools that has revolutionized the field of proteomics. Formerly known as high pressure liquid chromatography, this technique was introduced in the early 1960s to improve the efficiency of liquid chromatography separations using small stationary phase particles packed in columns. Since its introduction, continued advancements in column technology, development of different stationary phase materials and improved instrumentation has allowed the full potential of this technique to be realized...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27959355/embarking-on-a-research-project%C3%A2-or-research-for-the-absolute-novice
#12
L Wiblin, I Sleeman, D Burn
Research can be a difficult area for the novice to break into. A number of different obstacles face the new researcher, starting with selecting a suitable supervisor, writing a workable protocol and obtaining permissions from all the relevant organisations. This beginner's guide walks the fledging researcher through the required steps, including formulating a research question, designing a protocol and completing the Integrated Research Application System form to obtain the required permissions. The aim is to demystify the terms used in research and expose some of the pitfalls the authors experienced so that others can avoid them! Although challenges can arise throughout the research process, we aim to help you get underway...
September 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/27942029/predictors-of-participation-of-sophomore-medical-students-in-a-health-promoting-intervention-an-observational-study
#13
Thomas Kötter, Johanna Ritter, Alexander Katalinic, Edgar Voltmer
Medical students and doctors have to be particularly stress-resilient, as both medical education and practice are considered very stressful. Specific stressors can lead to increased risks of developing, for example, depression, anxiety and burnout. Relaxation techniques have proven to be effective for the prevention of these outcomes in student populations. However, only a very few medical students practice relaxation techniques regularly early on in their studies. Furthermore, it is unclear which students make use of stress-management offers and hence whether vulnerable students are generally reachable...
2016: PloS One
https://www.readbyqxmd.com/read/27936858/you-must-be-lying-because-i-don-t-understand-you-language-proficiency-and-lie-detection
#14
Elizabeth Elliott, Amy-May Leach
We examined the impact of interviewees' language proficiencies on observers' lie detection performance. Observers (N = 132) were randomly assigned to make deception judgments about interviewees (N = 56) from Four proficiency groups (i.e., native, advanced, intermediate, and beginner English speakers). Discrimination between lie- and truth-tellers was poorest when observers judged beginner English speakers compared to interviewees from any other proficiency group. Observers were also less likely to exhibit a truth-bias toward nonnative than native English speakers...
December 2016: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/27920581/hiv-stigma-and-associated-factors-among-antiretroviral-treatment-clients-in-jimma-town-southwest-ethiopia
#15
Neno Nikus Fido, Mamusha Aman, Zewdie Brihnu
BACKGROUND: HIV stigma has an important role in the spread of the AIDS epidemic. It profoundly affects the lives of individuals living with HIV/AIDS. Fear of being identified as having HIV may discourage a person from getting tested, accessing medical services, and obtaining medications. Thus, this study was aimed at assessing HIV-related stigma and associated factors among antiretroviral treatment (ART) clients in Jimma town, Oromia region, Southwest Ethiopia. METHODS: A facility-based cross-sectional study was conducted from March 11 to April 26, 2015, in ART clinics in Jimma town...
2016: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/27918404/entrepreneurship-assessing-the-readiness-of-the-new-jersey-apn-workforce
#16
Edna Cadmus, Mary L Johansen, Phyllis Arn Zimmer, David L Knowlton
There is an unprecedented opportunity to move advanced practice nurses (APNs) into primary care settings at a steady rate over the next 5 to 8 years. In addition, the opportunity for nurse-owned or nurse-led practices has never been greater. However, many APNs currently work in a structured environment where the employer focuses on the business aspects of the practice and the APN focuses primarily on clinical care. Often APNs are unaware of the entrepreneurial contribution they make to the practice. A Needs Assessment Survey was developed to better understand business and practice management knowledge and skills of APNs in New Jersey...
January 2017: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/27906942/lower-learning-difficulty-and-fluoroscopy-reduction-of-transforaminal-percutaneous-endoscopic-lumbar-discectomy-with-an-accurate-preoperative-location-method
#17
Guoxin Fan, Xin Gu, Yifan Liu, Xinbo Wu, Hailong Zhang, Guangfei Gu, Xiaofei Guan, Shisheng He
BACKGROUND: Transforaminal percutaneous endoscopic lumbar discectomy (tPELD) poses great challenges for junior surgeons. Beginners often require repeated attempts using fluoroscopy causing more punctures, which may significantly undermine their confidence and increase the radiation exposure to medical staff and patients. Moreover, the impact of an accurate location on the learning curve of tPELD has not been defined. OBJECTIVE: The study aimed to investigate the impact of an accurate preoperative location method on learning difficulty and fluoroscopy time of tPELD...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27896853/melanomas-versus-nevi-in-high-risk-patients-under-long-term-monitoring-with-digital-dermatoscopy-do-melanomas-and-nevi-already-differ-at-baseline
#18
P Tschandl, L Hofmann, C Fink, H Kittler, H A Haenssle
BACKGROUND: What lesions to select for a most efficient dermatoscopic monitoring of patients with multiple nevi remains an unresolved issue. OBJECTIVE: To compare the grade of atypia of melanomas and nevi of the same patient at baseline. METHODS: Prospective observational study using 236 dermatoscopic baseline images (59 quartets from 59 patients, each including 1 melanoma detected during follow-up and 3 nevi). Dermatologists (n=26) were asked to assess the "grade of dermatoscopic atypia" on a numerical scale and to identify the melanomas...
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27884614/robotic-major-hepatectomy-is%C3%A2-there-a-learning-curve
#19
Po-Da Chen, Chao-Yin Wu, Rey-Heng Hu, Chiung-Nien Chen, Ray-Hwang Yuan, Jin-Tung Liang, Hong-Shiee Lai, Yao-Ming Wu
BACKGROUND: Robotic hepatectomy has been suggested as a safe and effective management of liver disease. However, no large case series have documented the learning curve for robotic major hepatectomy. METHOD: We conducted a retrospective study for robotic major hepatectomy performed by the same operative team between January 2012 and October 2015 and evaluated the learning curve for operation time using the cumulative sum method, presented as cumulative sumoperation time...
November 21, 2016: Surgery
https://www.readbyqxmd.com/read/27882915/characteristic-of-shoulder-and-hip-rotation-range-of-motion-in-adolescent-tennis-players
#20
Bi F Chang, Chia C Liu, Hsiao Y Chang
BACKGROUND: Adolescent tennis players require sufficient hip and shoulder flexibility to achieve the kinetic chain of a tennis stroke or serve. Hence, the objective of this study is to measure the glenohumeral joint internal and external rotation (IR and ER, respectively) and hip ER range of motion and to compare these parameters between experienced and beginner-level adolescent tennis players. METHODS: Twenty-three adolescent tennis players were divided into experienced (N = 12) and beginner groups (N = 11) on the basis of the adolescent national ranking of the Taiwan Tennis Association...
November 24, 2016: Journal of Sports Medicine and Physical Fitness
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