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https://www.readbyqxmd.com/read/29662893/detecting-early-warning-signal-of-influenza-a-disease-using-sample-specific-dynamical-network-biomarkers
#1
Shanshan Zhu, Jie Gao, Tao Ding, Junhua Xu, Min Wu
Aims/Introduction . Evidences have shown that the deteriorated procession of disease is not a smooth change with time and conditions, in which a critical transition point denoted as predisease state drives the state from normal to disease. Considering individual differences, this paper provides a sample-specific method that constructs an index with individual-specific dynamical network biomarkers (DNB) which are defined as early warning index (EWI) for detecting predisease state of individual sample. Based on microarray data of influenza A disease, 144 genes are selected as DNB and the 7th time period is defined as predisease state...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29649758/association-between-nighttime-artificial-light-pollution-and-sea-turtle-nest-density-along-florida-coast-a-geospatial-study-using-viirs-remote-sensing-data
#2
Zhiyong Hu, Hongda Hu, Yuxia Huang
Artificial lighting at night has becoming a new type of pollution posing an important anthropogenic environmental pressure on organisms. The objective of this research was to examine the potential association between nighttime artificial light pollution and nest densities of the three main sea turtle species along Florida beaches, including green turtles, loggerheads, and leatherbacks. Sea turtle survey data was obtained from the "Florida Statewide Nesting Beach Survey program". We used the new generation of satellite sensor "Visible Infrared Imaging Radiometer Suite (VIIRS)" (version 1 D/N Band) nighttime annual average radiance composite image data...
April 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29556732/theoretical-investigation-of-the-structures-and-properties-of-cl-20-dnb-cocrystal-and-associated-pbxs-by-molecular-dynamics-simulation
#3
Gui-Yun Hang, Wen-Li Yu, Tao Wang, Zhen Li
In this work, a CL-20/DNB cocrystal explosive model was established and six different kinds of fluoropolymers, i.e., PVDF, PCTFE, F2311 , F2312 , F2313 and F2314 were added into the (1 0 0), (0 1 0), (0 0 1) crystal orientations to obtain the corresponding polymer bonded explosives (PBXs). The influence of fluoropolymers on PBX properties (energetic property, stability and mechanical properties) was investigated and evaluated using molecular dynamics (MD) methods. The results reveal a decrease in engineering moduli, an increase in Cauchy pressure (i...
March 19, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29544179/combining-pyrosequencing-and-isotopic-approaches-to-assess-denitrification-in-a-hyporheic-zone
#4
Heejung Kim, Dugin Kaown, Bernhard Mayer, Jin-Yong Lee, Kang-Kun Lee
Hyporheic zones are considered hot spots for numerically vast and phylogenetically diverse microbial communities. However, biogeochemical effects of hyporheic zones have rarely been investigated in detail because of the difficulty in accurately measuring denitrification in these zones. To date, little is known about the hydroecology of hyporheic zones. The effect of changes in hydraulic conditions on the community variations of indigenous microorganisms and water quality was examined based on the depth of the hyporheic zone...
March 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29528286/nociceptive-interneurons-control-modular-motor-pathways-to-promote-escape-behavior-in-drosophila
#5
Anita Burgos, Ken Honjo, Tomoko Ohyama, Cheng Sam Qian, Grace Ji-Eun Shin, Daryl M Gohl, Marion Silies, W Daniel Tracey, Marta Zlatic, Albert Cardona, Wesley B Grueber
Rapid and efficient escape behaviors in response to noxious sensory stimuli are essential for protection and survival. Yet, how noxious stimuli are transformed to coordinated escape behaviors remains poorly understood. In Drosophila larvae, noxious stimuli trigger sequential body bending and corkscrew-like rolling behavior. We identified a population of interneurons in the nerve cord of Drosophila , termed Down-and-Back (DnB) neurons, that are activated by noxious heat, promote nociceptive behavior, and are required for robust escape responses to noxious stimuli...
March 12, 2018: ELife
https://www.readbyqxmd.com/read/29455096/total-inorganic-nitrogen-removal-during-the-partial-complete-nitrification-for-treating-domestic-wastewater-removal-pathways-and-main-influencing-factors
#6
Xueyang Zhou, Xiuhong Liu, Siting Huang, Bin Cui, Zhibin Liu, Qing Yang
Achieving nitrite accumulation was considered as the prerequisite of ANAMMOX, which hindered the application of ANAMMOX. In this study, total inorganic nitrogen (TIN) removal during the partial/complete nitrification was studied in a lab-scale sequencing batch reactor (SBR) for treating domestic wastewater. The results showed TIN was removed by denitrification, ANAMMOX and N2 O emission during the partial/complete nitrification. AOB, AOA, Nitrobacter (NB), Nitrospira (NS), AnAOB and DNB were coexisted in the partial/complete nitrification...
May 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29445139/dynamic-network-biomarker-indicates-pulmonary-metastasis-at-the-tipping-point-of-hepatocellular-carcinoma
#7
Biwei Yang, Meiyi Li, Wenqing Tang, Weixin Liu, Si Zhang, Luonan Chen, Jinglin Xia
Developing predictive biomarkers that can detect the tipping point before metastasis of hepatocellular carcinoma (HCC), is critical to prevent further irreversible deterioration. To discover such early-warning signals or biomarkers of pulmonary metastasis in HCC, we analyse time-series gene expression data in spontaneous pulmonary metastasis mice HCCLM3-RFP model with our dynamic network biomarker (DNB) method, and identify CALML3 as a core DNB member. All experimental results of gain-of-function and loss-of-function studies show that CALML3 could indicate metastasis initiation and act as a suppressor of metastasis...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29405670/low-concentration-distal-nerve-blocks-with-0-125-levobupivacaine-versus-systemic-analgesia-for-ambulatory-trapeziectomy-performed-under-axillary-block-a-randomized-controlled-trial
#8
Mireia Rodríguez, FJavier González, Sergi Sabaté, Mercedes García, Claudia Lamas, Adrià Font, Marisa Moreno, Ignasi Proubasta, M Àngels Gil, M Victoria Moral, Rolf Hoffmann
BACKGROUND: Trapeziectomy is one of the most painful procedures in ambulatory surgery. This prospective randomized trial aimed to compare postoperative pain control using distal peripheral nerve blocks (dPNB) with a low concentration of a long-acting local anaesthetic versus conventional systemic analgesia. METHODS: Fifty-two patients undergoing trapeziectomy were randomized to receive levobupivacaine 0.125% 5ml on radial and median nerves at the elbow (dNB group), or not to receive these blocks (control group)...
February 5, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29259082/cyanide-production-by-chromobacterium-piscinae-shields-it-from-bdellovibrio-bacteriovorus-hd100-predation
#9
Wonsik Mun, Heeun Kwon, Hansol Im, Seong Yeol Choi, Ajay K Monnappa, Robert J Mitchell
Predation of Chromobacterium piscinae by Bdellovibrio bacteriovorus HD100 was inhibited in dilute nutrient broth (DNB) but not in HEPES. Experiments showed that the effector responsible was present in the medium, as cell-free supernatants retained the ability to inhibit predation, and that the effector was not toxic to B. bacteriovorus Violacein, a bisindole secondary metabolite produced by C. piscinae , was not responsible. Further characterization of C. piscinae found that this species produces sufficient concentrations of cyanide (202 µM) when grown in DNB to inhibit the predatory activity of B...
December 19, 2017: MBio
https://www.readbyqxmd.com/read/29099776/towards-the-development-of-a-low-cost-device-for-the-detection-of-explosives-vapors-by-fluorescence-quenching-of-conjugated-polymers-in-solid-matrices
#10
Liliana M Martelo, Tiago F Pimentel das Neves, João Figueiredo, Lino Marques, Alexander Fedorov, Ana Charas, Mário N Berberan-Santos, Hugh D Burrows
Conjugated polymers (CPs) have proved to be promising chemosensory materials for detecting nitroaromatic explosives vapors, as they quickly convert a chemical interaction into an easily-measured high-sensitivity optical output. The nitroaromatic analytes are strongly electron-deficient, whereas the conjugated polymer sensing materials are electron-rich. As a result, the photoexcitation of the CP is followed by electron transfer to the nitroaromatic analyte, resulting in a quenching of the light-emission from the conjugated polymer...
November 3, 2017: Sensors
https://www.readbyqxmd.com/read/29098729/clinical-severity-in-japanese-patients-with-neurofibromatosis-1-based-on-dnb-classification
#11
Yuko Ehara, Osamu Yamamoto, Kenjiro Kosaki, Yuichi Yoshida
Neurofibromatosis 1 (NF1) is a genetic disease characterized by cutaneous, neurological and osseous complications. Although clinical manifestations of NF1 are variable, there has been no report on evaluation of severity in patients with NF1. To elucidate the grade of severity of NF1, a retrospective study was conducted in 124 NF1 patients at the Department of Dermatology of Tottori University Hospital in 2007-2016. The DNB classification (dermatological, neurological and bone manifestations) in Japan was used for assessment...
November 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29080267/synthesis-of-new-c3-symmetric-amino-acid-and-aminoalcohol-containing-chiral-stationary-phases-and-application-to-hplc-enantioseparations
#12
Jeongjae Yu, Daniel W Armstrong, Jae Jeong Ryoo
We recently reported a new C3-symmetric (R)-phenylglycinol N-1,3,5-benzenetricarboxylic acid-derived chiral high-performance liquid chromatography (HPLC) stationary phase (CSP 1) that demonstrated better results as compared to a previously described N-3,5-dintrobenzoyl (DNB) (R)-phenylglycinol-derived CSP. Over a decade ago, (S)-leucinol, (R)-phenylglycine, and (S)-leucine derivatives were used as the starting materials of 3,5-DNB-based Pirkle-type CSPs for chiral separation. In this study, three new C3-symmetric CSPs (CSP 2, 3, and 4) were prepared by combining the ideas and results mentioned above...
January 2018: Chirality
https://www.readbyqxmd.com/read/29059471/preparation-and-evaluation-of-a-chiral-hplc-stationary-phase-based-on-cone-calix-4-arene-functionalized-at-the-upper-rim-with-l-alanine-units
#13
Sadegh Yaghoubnejad, Kourosh Tabar Heydar, Seyyed Hamid Ahmadi, Reza Zadmard
Here we report a new chiral stationary phase (CSP) immobilized on silica gel based on cone calix[4]arene functionalized at the upper rim with two l-alanine units as new chiral selector that has been used in high-performance liquid chromatography. The CSP was prepared by covalently bonding the allyl groups at the lower rim of calix[4]arene to silica gel by thiol-ene click chemistry reaction. Elemental analysis of the CSP showed that 120 μmol of chiral selector bonded per gram of silica gel. 1-Hexene was used for end-capping of unreacted mercapto groups on silica gel...
March 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29047874/optimized-calibration-methodology-of-viirs-day-night-band-low-gain-stage-using-a-solar-diffuser
#14
Junqiang Sun, Menghua Wang
An enhanced methodology of the standard on-orbit calibration of the day-night band (DNB) of the visible infrared imaging radiometer suite on board the Suomi National Polar-orbiting Partnership satellite is presented, specifically for the low-gain stage. The range of the "sweet spot" for the fully illuminated scans in the calibration events is expanded from 4° to 7.8° in order to increase the number of fully illuminated scans to 72, which then permits a complete calibration of the DNB to be carried out within one orbit for all 36 aggregated modes and the two mirror sides...
May 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29027943/low-grade-dysplastic-nodules-revealed-as-the-tipping-point-during-multistep-hepatocarcinogenesis-by-dynamic-network-biomarkers
#15
Lina Lu, Zhonglin Jiang, Yulin Dai, Luonan Chen
Hepatocellular carcinoma (HCC) is a complex disease with a multi-step carcinogenic process from preneoplastic lesions, including cirrhosis, low-grade dysplastic nodules (LGDNs), and high-grade dysplastic nodules (HGDNs) to HCC. There is only an elemental understanding of its molecular pathogenesis, for which a key problem is to identify when and how the critical transition happens during the HCC initiation period at a molecular level. In this work, for the first time, we revealed that LGDNs is the tipping point (i...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/28981699/individual-specific-edge-network-analysis-for-disease-prediction
#16
Xiangtian Yu, Jingsong Zhang, Shaoyan Sun, Xin Zhou, Tao Zeng, Luonan Chen
Predicting pre-disease state or tipping point just before irreversible deterioration of health is a difficult task. Edge-network analysis (ENA) with dynamic network biomarker (DNB) theory opens a new way to study this problem by exploring rich dynamical and high-dimensional information of omics data. Although theoretically ENA has the ability to identify the pre-disease state during the disease progression, it requires multiple samples for such prediction on each individual, which are generally not available in clinical practice, thus limiting its applications in personalized medicine...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28955757/the-para-isomer-of-dinitrobenzene-disrupts-redox-homeostasis-in-liver-and-kidney-of-male-wistar-rats
#17
Janet Olayemi Sangodele, Mary Tolulope Olaleye, Thomas K Monsees, Afolabi Clement Akinmoladun
BACKGROUND: Para-Dinitrobenzene (p-DNB) is one of the isomers of dinitrobenzene which have been detected as environmental toxicants. Skin irritation and organ toxicities are likely for industrial workers exposed to p-DNB. This study evaluated the effect of sub-chronic exposure of rats to p-DNB on cellular redox balance, hepatic and renal integrity. METHODS: Forty eight male Wistar rats weighing 160-180 g were administered 50, 75, 1000 and 2000 mg/kg b.wt (body weight) of p-DNB or an equivalent volume of vehicle (control) orally and topically for 14 days...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28880094/enantiospecific-synthesis-of-%C3%AE-substituted-tryptamines
#18
Heather N Rubin, Kinney Van Hecke, Jonathan J Mills, Jennifer Cockrell, Jeremy B Morgan
Functionalized tryptamines are targets of interest for development as small molecule therapeutics. The ring opening of aziridines with indoles is a powerful method for tryptamine synthesis where isomer formation can be controlled. 3,5-Dinitrobenzoyl (DNB)-protected aziridines undergo regioselective, enantiospecific ring opening to produce β-substituted tryptamines for a series of indoles. Attack at the more substituted aziridine carbon occurs in an SN2-like fashion to generate DNB-tryptamine products as synthetic precursors...
September 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28678795/quantifying-critical-states-of-complex-diseases-using-single-sample-dynamic-network-biomarkers
#19
Xiaoping Liu, Xiao Chang, Rui Liu, Xiangtian Yu, Luonan Chen, Kazuyuki Aihara
Dynamic network biomarkers (DNB) can identify the critical state or tipping point of a disease, thereby predicting rather than diagnosing the disease. However, it is difficult to apply the DNB theory to clinical practice because evaluating DNB at the critical state required the data of multiple samples on each individual, which are generally not available, and thus limit the applicability of DNB. In this study, we developed a novel method, i.e., single-sample DNB (sDNB), to detect early-warning signals or critical states of diseases in individual patients with only a single sample for each patient, thus opening a new way to predict diseases in a personalized way...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28655161/dysfunction-of-pla2g6-and-cyp2c44-associated-network-signals-imminent-carcinogenesis-from-chronic-inflammation-to-hepatocellular-carcinoma
#20
Meiyi Li, Chen Li, Wei-Xin Liu, Conghui Liu, Jingru Cui, Qingrun Li, Hong Ni, Yingcheng Yang, Chaochao Wu, Chunlei Chen, Xing Zhen, Tao Zeng, Mujun Zhao, Lei Chen, Jiarui Wu, Rong Zeng, Luonan Chen
Little is known about how chronic inflammation contributes to the progression of hepatocellular carcinoma (HCC), especially the initiation of cancer. To uncover the critical transition from chronic inflammation to HCC and the molecular mechanisms at a network level, we analyzed the time-series proteomic data of woodchuck hepatitis virus/c-myc mice and age-matched wt-C57BL/6 mice using our dynamical network biomarker (DNB) model. DNB analysis indicated that the 5th month after birth of transgenic mice was the critical period of cancer initiation, just before the critical transition, which is consistent with clinical symptoms...
December 1, 2017: Journal of Molecular Cell Biology
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