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https://www.readbyqxmd.com/read/29099776/towards-the-development-of-a-low-cost-device-for-the-detection-of-explosives-vapors-by-fluorescence-quenching-of-conjugated-polymers-in-solid-matrices
#1
Liliana M Martelo, Tiago F Pimentel das Neves, João Figueiredo, Lino Marques, Alexander Fedorov, Ana Charas, Mário N Berberan-Santos, Hugh D Burrows
Conjugated polymers (CPs) have proved to be promising chemosensory materials for detecting nitroaromatic explosives vapors, as they quickly convert a chemical interaction into an easily-measured high-sensitivity optical output. The nitroaromatic analytes are strongly electron-deficient, whereas the conjugated polymer sensing materials are electron-rich. As a result, the photoexcitation of the CP is followed by electron transfer to the nitroaromatic analyte, resulting in a quenching of the light-emission from the conjugated polymer...
November 3, 2017: Sensors
https://www.readbyqxmd.com/read/29098729/clinical-severity-in-japanese-patients-with-neurofibromatosis-1-based-on-dnb-classification
#2
Yuko Ehara, Osamu Yamamoto, Kenjiro Kosaki, Yuichi Yoshida
Neurofibromatosis 1 (NF1) is a genetic disease characterized by cutaneous, neurological and osseous complications. Although clinical manifestations of NF1 are variable, there has been no report on evaluation of severity in patients with NF1. To elucidate the grade of severity of NF1, a retrospective study was conducted in 124 NF1 patients at the Department of Dermatology of Tottori University Hospital in 2007-2016. The DNB classification (dermatological, neurological and bone manifestations) in Japan was used for assessment...
November 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29080267/synthesis-of-new-c3-symmetric-amino-acid-and-aminoalcohol-containing-chiral-stationary-phases-and-application-to-hplc-enantioseparations
#3
Jeongjae Yu, Daniel W Armstrong, Jae Jeong Ryoo
We recently reported a new C3-symmetric (R)-phenylglycinol N-1,3,5-benzenetricarboxylic acid-derived chiral high-performance liquid chromatography (HPLC) stationary phase (CSP 1) that demonstrated better results as compared to a previously described N-3,5-dintrobenzoyl (DNB) (R)-phenylglycinol-derived CSP. Over a decade ago, (S)-leucinol, (R)-phenylglycine, and (S)-leucine derivatives were used as the starting materials of 3,5-DNB-based Pirkle-type CSPs for chiral separation. In this study, three new C3-symmetric CSPs (CSP 2, 3, and 4) were prepared by combining the ideas and results mentioned above...
October 28, 2017: Chirality
https://www.readbyqxmd.com/read/29059471/preparation-and-evaluation-of-a-chiral-hplc-stationary-phase-based-on-cone-calix-4-arene-functionalized-at-the-upper-rim-with-l-alanine-units
#4
Sadegh Yaghoubnejad, Kourosh Tabar Heydar, Seyyed Hamid Ahmadi, Reza Zadmard
Here we report a new chiral stationary phase (CSP) immobilized on silica gel based on cone calix[4]arene functionalized at the upper rim with two L-alanine units as new chiral selector that has been used in high performance liquid chromatography. The CSP was prepared by covalently bonding the allyl groups at the lower rim of calix[4]arene to silica gel by thiol-ene click chemistry reaction. Elemental analysis of the CSP showed that 120 μmol of chiral selector bonded per gram of silica gel. 1-Hexene was used for end-capping of unreacted mercapto groups on silica gel...
October 23, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29047874/optimized-calibration-methodology-of-viirs-day-night-band-low-gain-stage-using-a-solar-diffuser
#5
Junqiang Sun, Menghua Wang
An enhanced methodology of the standard on-orbit calibration of the day-night band (DNB) of the visible infrared imaging radiometer suite on board the Suomi National Polar-orbiting Partnership satellite is presented, specifically for the low-gain stage. The range of the "sweet spot" for the fully illuminated scans in the calibration events is expanded from 4° to 7.8° in order to increase the number of fully illuminated scans to 72, which then permits a complete calibration of the DNB to be carried out within one orbit for all 36 aggregated modes and the two mirror sides...
May 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29027943/low-grade-dysplastic-nodules-revealed-as-the-tipping-point-during-multistep-hepatocarcinogenesis-by-dynamic-network-biomarkers
#6
Lina Lu, Zhonglin Jiang, Yulin Dai, Luonan Chen
Hepatocellular carcinoma (HCC) is a complex disease with a multi-step carcinogenic process from preneoplastic lesions, including cirrhosis, low-grade dysplastic nodules (LGDNs), and high-grade dysplastic nodules (HGDNs) to HCC. There is only an elemental understanding of its molecular pathogenesis, for which a key problem is to identify when and how the critical transition happens during the HCC initiation period at a molecular level. In this work, for the first time, we revealed that LGDNs is the tipping point (i...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/28981699/individual-specific-edge-network-analysis-for-disease-prediction
#7
Xiangtian Yu, Jingsong Zhang, Shaoyan Sun, Xin Zhou, Tao Zeng, Luonan Chen
Predicting pre-disease state or tipping point just before irreversible deterioration of health is a difficult task. Edge-network analysis (ENA) with dynamic network biomarker (DNB) theory opens a new way to study this problem by exploring rich dynamical and high-dimensional information of omics data. Although theoretically ENA has the ability to identify the pre-disease state during the disease progression, it requires multiple samples for such prediction on each individual, which are generally not available in clinical practice, thus limiting its applications in personalized medicine...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28955757/the-para-isomer-of-dinitrobenzene-disrupts-redox-homeostasis-in-liver-and-kidney-of-male-wistar-rats
#8
Janet Olayemi Sangodele, Mary Tolulope Olaleye, Thomas K Monsees, Afolabi Clement Akinmoladun
BACKGROUND: Para-Dinitrobenzene (p-DNB) is one of the isomers of dinitrobenzene which have been detected as environmental toxicants. Skin irritation and organ toxicities are likely for industrial workers exposed to p-DNB. This study evaluated the effect of sub-chronic exposure of rats to p-DNB on cellular redox balance, hepatic and renal integrity. METHODS: Forty eight male Wistar rats weighing 160-180 g were administered 50, 75, 1000 and 2000 mg/kg b.wt (body weight) of p-DNB or an equivalent volume of vehicle (control) orally and topically for 14 days...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28880094/enantiospecific-synthesis-of-%C3%AE-substituted-tryptamines
#9
Heather N Rubin, Kinney Van Hecke, Jonathan J Mills, Jennifer Cockrell, Jeremy B Morgan
Functionalized tryptamines are targets of interest for development as small molecule therapeutics. The ring opening of aziridines with indoles is a powerful method for tryptamine synthesis where isomer formation can be controlled. 3,5-Dinitrobenzoyl (DNB)-protected aziridines undergo regioselective, enantiospecific ring opening to produce β-substituted tryptamines for a series of indoles. Attack at the more substituted aziridine carbon occurs in an SN2-like fashion to generate DNB-tryptamine products as synthetic precursors...
September 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28678795/quantifying-critical-states-of-complex-diseases-using-single-sample-dynamic-network-biomarkers
#10
Xiaoping Liu, Xiao Chang, Rui Liu, Xiangtian Yu, Luonan Chen, Kazuyuki Aihara
Dynamic network biomarkers (DNB) can identify the critical state or tipping point of a disease, thereby predicting rather than diagnosing the disease. However, it is difficult to apply the DNB theory to clinical practice because evaluating DNB at the critical state required the data of multiple samples on each individual, which are generally not available, and thus limit the applicability of DNB. In this study, we developed a novel method, i.e., single-sample DNB (sDNB), to detect early-warning signals or critical states of diseases in individual patients with only a single sample for each patient, thus opening a new way to predict diseases in a personalized way...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28655161/dysfunction-of-pla2g6-and-cyp2c44-associated-network-signals-imminent-carcinogenesis-from-chronic-inflammation-to-hepatocellular-carcinoma
#11
Meiyi Li, Chen Li, Wei-Xin Liu, Conghui Liu, Jingru Cui, Qingrun Li, Hong Ni, Yingcheng Yang, Chaochao Wu, Chunlei Chen, Xing Zhen, Tao Zeng, Mujun Zhao, Lei Chen, Jiarui Wu, Rong Zeng, Luonan Chen
Little is known about how chronic inflammation contributes to the progression of hepatocellular carcinoma (HCC), especially the initiation of cancer. To uncover the critical transition from chronic inflammation to HCC and the molecular mechanisms at a network level, we analyzed the time-series proteomic data of woodchuck hepatitis virus/c-myc mice and age-matched wt-C57BL/6 mice using our dynamical network biomarker (DNB) model. DNB analysis indicated that the 5th month after birth of transgenic mice was the critical period of cancer initiation, just before the critical transition, which is consistent with clinical symptoms...
June 26, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28639307/anti-d-in-a-mother-hemizygous-for-the-variant-rhd-dnb-gene-associated-with-hemolytic-disease-of-the-fetus-and-newborn
#12
Kelli M Quantock, Genghis H Lopez, Catherine A Hyland, Yew-Wah Liew, Robert L Flower, Frans J Niemann, Arthur Joyce
BACKGROUND: Individuals with the partial D phenotype when exposed to D+ red blood cells (RBCs) carrying the epitopes they lack may develop anti-D specific for the missing epitopes. DNB is the most common partial D in Caucasians and the clinical significance for anti-D in these individuals is unknown. STUDY DESIGN AND METHODS: This article describes the serologic genotyping results and clinical manifestations in two group D+ babies of a mother presenting as group O, D+ with alloanti-D...
August 2017: Transfusion
https://www.readbyqxmd.com/read/28611995/an-update-on-the-disappearing-nail-bed
#13
Ralph Daniel, Babaev Meir, Shemer Avner
BACKGROUND: The nail bed may epithelialize and develop dermatoglyphics after long-standing onycholysis. We have called this phenomenon the disappearing nail bed (DNB). DNB may present as a shortened or narrow nail bed. METHODS: Examination of all 20 nails was performed in each patient enrolled to the study. DNB was defined as the presence of a nail which is at least 20% shorter and/or narrower than the identical nail on the opposite hand or foot. Age, sex, and nail history were recorded...
March 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28386202/detecting-early-warning-signals-for-influenza-a-pandemic-based-on-protein-dynamical-network-biomarkers
#14
Jie Gao, Kang Wang, Tao Ding
The outbreak of influenza A comes from a relatively stable state is a critical phenomenon on epidemic. In this paper, influenza A varying from different states is studied in the method of dynamical network biomarkers (DNB). Through studying DNB of influenza A virus protein, we can detect the warning signals of outbreak for influenza A and obtain a composite index. The composite index varies along with the state of pandemic influenza, which gives a clue showing the turn point of outbreak. The low value (<1) steady state of the composite index means influenza A is normally in the relatively steady stage...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28379488/a-reference-human-genome-dataset-of-the-bgiseq-500-sequencer
#15
Jie Huang, Xinming Liang, Yuankai Xuan, Chunyu Geng, Yuxiang Li, Haorong Lu, Shoufang Qu, Xianglin Mei, Hongbo Chen, Ting Yu, Nan Sun, Junhua Rao, Jiahao Wang, Wenwei Zhang, Ying Chen, Sha Liao, Hui Jiang, Xin Liu, Zhaopeng Yang, Feng Mu, Shangxian Gao
BGISEQ-500 is a new desktop sequencer developed by BGI. Using DNA nanoball and combinational probe anchor synthesis developed from Complete Genomics™ sequencing technologies, it generates short reads at a large scale. Here, we present the first human whole-genome sequencing dataset of BGISEQ-500. The dataset was generated by sequencing the widely used cell line HG001 (NA12878) in two sequencing runs of paired-end 50 bp (PE50) and two sequencing runs of paired-end 100 bp (PE100). We also include examples of the raw images from the sequencer for reference...
May 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28314147/boron-doped-diamond-electrode-preparation-characterization-and-application-for-electrocatalytic-degradation-of-m-dinitrobenzene
#16
Hongmei Bai, Ping He, Jing Pan, Jingchao Chen, Yang Chen, Faqing Dong, Hong Li
Boron-doped diamond (BDD) electrode was successfully prepared via microwave plasma chemical vapor deposition method and it was used in electrocatalytic degradation of m-dinitrobenzene (m-DNB). The electrocatalytic degradation efficiency of m-DNB was evaluated under different experimental parameters including current density, temperature, pH, Na2SO4 concentration and initial m-DNB concentration. Under optimal parameters, degradation efficiency of m-DNB reached up to 82.7% after 150min. The degradation process of m-DNB was fitted well with pseudo first-order kinetics...
July 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28299268/role-of-addition-of-dexamethasone-to-lignocaine-2-with-adrenaline-in-dental-nerve-blocks-for-third-molar-surgery-a-prospective-randomized-control-trial
#17
Saroj Prasad Deo
CONTEXT: Dexamethasone has been frequently used in oral surgical procedure and accepted by oral and maxillofacial surgeon community worldwide. However, this is the first clinical trial that used dexamethasone as adjuvant with lignocaine in dental nerve block (DNB). AIMS: The purpose of this double-blind, randomized control trial (RCT) was to compare the effect of dexamethasone with normal saline (NS) in a lignocaine DNB. SETTINGS AND DESIGN: This prospective, double-blind, RCT was carried out after obtaining approval from the Institutional Ethical Committee...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28293816/triphenylbenzene-sensor-for-selective-detection-of-picric-acid
#18
S Nagendran, Pratap Vishnoi, Ramaswamy Murugavel
A C 3-symmetric triphenylbenzene based photoluminescent compound, 1,3,5-tris(4'-(N-methylamino)phenyl) benzene ([NHMe]3TAPB), has been synthesized by mono-N-methylation of 1,3,5-tris(4'-aminophenyl) benzene (TAPB) and structurally characterized. [NHMe]3TAPB acts as a selective fluorescent sensor for picric acid (PA) with a detection limit as low as 2.25 ppm at a signal to noise ratio of 3. Other related analytes (i.e. TNT, DNT and DNB) show very little effect on the fluorescence intensity of [NHMe]3TAPB. The selectivity is triggered by proton transfer from picric acid to the fluorophore and ground-state complex formation between the protonated fluorophore and picrate anion through hydrogen bonding interactions...
July 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28126659/molecular-engineering-of-a-mitochondrial-targeting-two-photon-in-and-near-infrared-out-fluorescent-probe-for-gaseous-signal-molecules-h2s-in-deep-tissue-bioimaging
#19
Liyi Zhou, Danqing Lu, Qianqian Wang, Sihua Liu, Qinlu Lin, Hongyan Sun
Hydrogen sulfide (H2S), one of the biologically important gaseous signal molecules, plays an essential role in diverse normal biochemical functions and pathological processes. Herein, an efficient two-photon in and near-infrared out mitochondria-targeting dye has been designed, synthesized and characterized. It is easily synthesized by the condensation reaction (C˭C) of 4-hydroxybenzaldehyde and 6-(diethylamino)-1,2,3,4-tetrahydroxanthylium (mitochondria-targeting), which possesses large two-photon action absorption cross-section ~160g and high fluorescence quantum yield ~0...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28053822/bulbocavernosus-reflex-test-for-diagnosis-of-pudendal-nerve-injury-in-female-patients-with-diabetic-neurogenic-bladder
#20
Xiaoting Niu, Xun Wang, Huanjie Huang, Peiqi Ni, Yuanshao Lin, Bei Shao
The study was designed to investigate the clinical application and significance of the bulbocavernosus reflex (BCR) test for diagnosing diabetic neurogenic bladder (DNB) in female subjects. In this study, 68 female patients with DNB and 40 female normal controls were subjected to a nerve conduction study (NCS) of all four limbs and the BCR test. The data were analyzed and compared, and the corresponding diagnostic sensitivities were discussed. Mean BCR latency for female DNB patients was significantly prolonged, compared to that of the control group, suggesting pudendal nerve injuries in female DNB patients...
December 2016: Aging and Disease
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