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https://www.readbyqxmd.com/read/27815138/pharmaceutical-salts-of-ethionamide-with-gras-counter-ion-donors-to-enhance-the-solubility
#1
N Sunil Kumar, Darshak R Trivedi
Pharmaceutical salts of BCS class II second line anti-tuberculosis drug ethionamide (ETH) with various counter ions namely, 2-chloro-4-nitrobenzoic acid (CNB), 2,6-dihydroxybenzoic acid (2,6HBA), 2,3-dihydroxybenzoic acid (2,3HBA) and 2,4-dinitrobenzoic acid (DNB) were synthesized by crystal engineering approach. All the synthesized salts were characterized by various spectroscopic (NMR, FT-IR,), thermal (DSC & TGA) and PXRD techniques. The crystal structure of the synthesized salts was determined by single-crystal X-ray diffraction techniques...
November 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27730795/do-legal-issues-deserve-space-in-specialty-medical-journals
#2
Neeraj Nagpal
Physicians and Internists in India have tended to brush under the carpet legal issues affecting their profession. Of concern to all Physicians is the judgment in a recent case where the NCDRC has stated that if MD Medicine Physicians write Physician & Cardiologist on their letterhead it is Quackery. What is MD Medicine degree holder in India qualified and trained to treat ? These are issues which need debate and that can only be initiated once we recognize that there is a problem. Either an MD Medicine is a cardiologist or he is not...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27705834/1-3-dinitrobenzene-reductive-degradation-by-alkaline-ascorbic-acid-reaction-mechanisms-degradation-pathways-and-reagent-optimization
#3
Chiya Ciou, Chenju Liang
Nitro-aromatic compounds (NACs) such as 1,3-dinitrobenzene (1,3-DNB) contain the nitrogroup (-NO2), in which the N with a +III oxidation state accepts electrons. Water soluble ascorbic acid (AsA) at elevated pH produces electron transfer and governs the electron-donating pathway. The influence of the NaOH/AsA molar ratio on the degradation of 1,3-DNB was investigated. Using 0.21-2 M NaOH and 20-100 mM AsA, nearly complete 1,3-DNB removals (90-100%) were achieved within 0.5 h. On the basis of intermediates identified using GC/MS, the reduction pathways of 1,3-DNB can be categorized into step-by-step electron transfer, and condensation routes...
January 2017: Chemosphere
https://www.readbyqxmd.com/read/27606006/has-scots-pine-pinus-sylvestris-co-evolved-with-dothistroma-septosporum-in-scotland-evidence-for-spatial-heterogeneity-in-the-susceptibility-of-native-provenances
#4
Annika Perry, Anna V Brown, Stephen Cavers, Joan E Cottrell, Richard A Ennos
Spatial heterogeneity in pathogen pressure leads to genetic variation in, and evolution of, disease-related traits among host populations. In contrast, hosts are expected to be highly susceptible to exotic pathogens as there has been no evolution of defence responses. Host response to pathogens can therefore be an indicator of a novel or endemic pathosystem. Currently, the most significant threat to native British Scots pine (Pinus sylvestris) forests is Dothistroma needle blight (DNB) caused by the foliar pathogen Dothistroma septosporum which is presumed to be exotic...
September 2016: Evolutionary Applications
https://www.readbyqxmd.com/read/27587900/substantial-heritable-variation-for-susceptibility-to-dothistroma-septosporum-within-populations-of-native-british-scots-pine-pinus-sylvestris
#5
A Perry, W Wachowiak, A V Brown, R A Ennos, J E Cottrell, S Cavers
The threat from pests and pathogens to native and commercially planted forest trees is unprecedented and expected to increase under climate change. The degree to which forests respond to threats from pathogens depends on their adaptive capacity, which is determined largely by genetically controlled variation in susceptibility of the individual trees within them and the heritability and evolvability of this trait. The most significant current threat to the economically and ecologically important species Scots pine (Pinus sylvestris) is dothistroma needle blight (DNB), caused by the foliar pathogen Dothistroma septosporum...
August 2016: Plant Pathology
https://www.readbyqxmd.com/read/27500422/two-polymorphic-forms-of-a-six-coordinate-mononuclear-cobalt-ii-complex-with-easy-plane-anisotropy-structural-features-theoretical-calculations-and-field-induced-slow-relaxation-of-the-magnetization
#6
Subhadip Roy, Itziar Oyarzabal, Julia Vallejo, Joan Cano, Enrique Colacio, Antonio Bauza, Antonio Frontera, Alexander M Kirillov, Michael G B Drew, Subrata Das
A mononuclear cobalt(II) complex [Co(3,5-dnb)2(py)2(H2O)2] {3,5-Hdnb = 3,5-dinitrobenzoic acid; py = pyridine} was isolated in two polymorphs, in space groups C2/c (1) and P21/c (2). Single-crystal X-ray diffraction analyses reveal that 1 and 2 are not isostructural in spite of having equal formulas and ligand connectivity. In both structures, the Co(II) centers adopt octahedral {CoN2O4} geometries filled by pairs of mutually trans terminal 3,5-dnb, py, and water ligands. However, the structures of 1 and 2 disclose distinct packing patterns driven by strong intermolecular O-H···O hydrogen bonds, leading to their 0D→2D (1) or 0D→1D (2) extension...
September 6, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27399273/lysine-specific-proteolytic-activity-responsible-for-forsythia-detaching-factor-modification
#7
Hidetomo Onishi, Munehiko Ro, Takafumi Suzuki, Makiko Ishii, Hideharu Otsuka, Kazuhiro Yatabe, Joichiro Hayashi, Junichi Tatsumi, Kitetsu Shin
OBJECTIVES: The objective of the present study was to clarify the lysine-specific proteolytic activity derived from periodontal pathogens responsible for Forsythia detaching factor (FDF) modification. DESIGN: The activity responsible for FDF modification in Tannerella forsythia and Porphyromonas gingivalis were evaluated by colorimetric assay using Ac-Arg-Ala-Lys-p-nitroaniline as a substrate. FDF modification in T. forsythia and P. gingivalis were evaluated by Western blotting using recombinant FDF (rFDF) as a substrate...
June 25, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/26993042/discovering-a-critical-transition-state-from-nonalcoholic-hepatosteatosis-to-nonalcoholic-steatohepatitis-by-lipidomics-and-dynamical-network-biomarkers
#8
Rina Sa, Wanwei Zhang, Jing Ge, Xinben Wei, Yunhua Zhou, David R Landzberg, Zhenzhen Wang, Xianlin Han, Luonan Chen, Huiyong Yin
Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for type 2 diabetes and metabolic syndrome. However, accurately differentiating nonalcoholic steatohepatitis (NASH) from hepatosteatosis remains a clinical challenge. We identified a critical transition stage (termed pre-NASH) during the progression from hepatosteatosis to NASH in a mouse model of high fat-induced NAFLD, using lipidomics and a mathematical model termed dynamic network biomarkers (DNB). Different from the conventional biomarker approach based on the abundance of molecular expressions, the DNB model exploits collective fluctuations and correlations of different metabolites at a network level...
June 2016: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/26936406/an-electrochemical-sensor-for-nitrobenzene-using-%C3%AF-conjugated-polymer-embedded-nanosilver
#9
Victor M Kariuki, Sohaib A Fasih-Ahmad, Francis J Osonga, Omowunmi A Sadik
A novel electrochemical sensing platform for nitrobenzene has been developed using silver nanoparticles (AgNPs) embedded in the poly(amic) acid (PAA) polymer matrix (PAA-AgNPs). PAA was synthesized via the polycondensation reaction of para-phenylenediamine and benzene-1,2,4,5-tetracarboxylic dianhydride. PAA-AgNP nanocomposites were synthesized by the in situ reduction of a silver precursor by the polymer at room temperature in a one-step approach without using an extraneous reducing or capping agent. The composite was subsequently characterized in solution and as a thin film...
April 7, 2016: Analyst
https://www.readbyqxmd.com/read/26906975/using-multi-objective-optimization-to-identify-dynamical-network-biomarkers-as-early-warning-signals-of-complex-diseases
#10
Fatemeh Vafaee
Biomarkers have gained immense scientific interest and clinical value in the practice of medicine. With unprecedented advances in high-throughput technologies, research interest in identifying novel and customized disease biomarkers for early detection, diagnosis, or drug responses is rapidly growing. Biomarkers can be identified in different levels of molecular biomarkers, networks biomarkers and dynamical network biomarkers (DNBs). The latter is a recently developed concept which relies on the idea that a cell is a complex system whose behavior is emerged from interplay of various molecules, and this network of molecules dynamically changes over time...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26884655/an-analysis-of-the-origins-subjects-and-awards-received-for-presentations-at-the-annual-iasg-conferences-2009-2013
#11
Subhash Soni, Peush Sahni, Samiran Nundy
s presented at scientific meetings are important for making ongoing research more widely known and may also reflect the quality of the parent institution's standard of patient care. We analyzed the abstracts presented at the annual meetings of IASG for the past 5 years for (i) medium of presentation (oral/poster/videos), (ii) subjects discussed, (iii) institution of origin, (iv) whether a prospective/ retrospective study or a case report, (v) changing trends, and (vi) awards received. Of the 1340 abstracts analyzed, there were 18...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/26878937/visible-light-controlled-nitric-oxide-release-from-hindered-nitrobenzene-derivatives-for-specific-modulation-of-mitochondrial-dynamics
#12
Kai Kitamura, Mitsuyasu Kawaguchi, Naoya Ieda, Naoki Miyata, Hidehiko Nakagawa
Nitric oxide (NO) is a physiological signaling molecule, whose biological production is precisely regulated at the subcellular level. Here, we describe the design, synthesis, and evaluation of novel mitochondria-targeted NO releasers, Rol-DNB-mor and Rol-DNB-pyr, that are photocontrollable not only in the UV wavelength range but also in the biologically favorable visible wavelength range (530-590 nm). These caged NO compounds consist of a hindered nitrobenzene as the NO-releasing moiety and a rhodamine chromophore...
May 20, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/26857592/pentiptycene-based-luminescent-cu-ii-mof-exhibiting-selective-gas-adsorption-and-unprecedentedly-high-sensitivity-detection-of-nitroaromatic-compounds-nacs
#13
Minghui Zhang, Liangliang Zhang, Zhenyu Xiao, Qinhui Zhang, Rongming Wang, Fangna Dai, Daofeng Sun
The assembly of a fluorescent pentiptycene-based ligand with copper ion resulted in the formation of a 3D porous metal-organic framework (UPC-21) based on well-known paddlewheel SBUs. UPC-21 exhibits selective adsorption of CO2 over CH4 and N2 at 273 K and 295 K, C2H2 over CH4 at 273 K. The most significant performance of UPC-21 is its highly efficient detection of NACs such as 4-NP, 1,4-DNB, NB, and 1,3-DNB with the calculated quenching constants, Ksv, being 3.097 × 10(6), 1.406 × 10(6), 4...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26807394/the-2015-academic-college-of-emergency-experts-in-india-s-indo-us-joint-working-group-white-paper-on-establishing-an-academic-department-and-training-pediatric-emergency-medicine-specialists-in-india
#14
Prashant Mahajan, Prerna Batra, Binita R Shah, Abhijeet Saha, Sagar Galwankar, Praveen Aggrawal, Ameer Hassoun, Bipin Batra, Sanjeev Bhoi, Om Prakash Kalra, Dheeraj Shah
The concept of pediatric emergency medicine (PEM) is virtually nonexistent in India. Suboptimally, organized prehospital services substantially hinder the evaluation, management, and subsequent transport of the acutely ill and/or injured child to an appropriate facility. Furthermore, the management of the ill child at the hospital level is often provided by overburdened providers who, by virtue of their training, lack experience in the skills required to effectively manage pediatric emergencies. Finally, the care of the traumatized child often requires the involvement of providers trained in different specialities, which further impedes timely access to appropriate care...
October 2015: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/26802500/use-of-a-rat-ex-vivo-testis-culture-method-to-assess-toxicity-of-select-known-male-reproductive-toxicants
#15
Keith M Goldstein, David E Seyler, Philippe Durand, Marie-Hélène Perrard, Thomas K Baker
Due to the complex physiology of the testes, in vitro models have been largely unsuccessful at modeling testicular toxicity in vivo. We conducted a pilot study to evaluate the utility of the Durand ex vivo rat seminiferous tubule culture model [1-3] that supports spermatogenesis through meiosis II, including the formation of round spermatids. We used this system to evaluate the toxicity of four known testicular toxicants: 1,3-dinitrobenzene (DNB), 2-methoxyacetic acid (MAA), bisphenol A (BPA), and lindane over 21 days of culture...
April 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/26732881/enantioseparation-of-n-derivatized-amino-acids-by-micro-liquid-chromatography-laser-induced-fluorescence-detection-using-quinidine-based-monolithic-columns
#16
Huihui Wu, Qiqin Wang, Meng Ruan, Kun Peng, Peijie Zhu, Jacques Crommen, Hai Han, Zhengjin Jiang
A novel carbamoylated quinidine based monolith, namely poly(O-9-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-co-ethylene dimethacrylate (poly(MQD-co-EDMA)), was prepared for the micro-LC enantioseparation of N-derivatized amino acids. The influence of the mobile phase composition, including the organic modifier proportion, the apparent pH and the buffer concentration, on the enantioresolution of N-derivatized amino acids was systematically investigated. Satisfactory column performance in terms of permeability, efficiency and reproducibility was obtained in most cases...
March 20, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26713991/the-2015-academic-college-of-emergency-experts-in-indias-indo-us-joint-working-group-white-paper-on-establishing-an-academic-department-and-training-pediatric-emergency-medicine-specialists-in-india
#17
Prashant Mahajan, Prerna Batra, Binita R Shah, Abhijeet Saha, Sagar Galwankar, Praveen Aggrawal, Ameer Hassoun, Bipin Batra, Sanjeev Bhoi, Om Prakash Kalra, Dheeraj Shah
The concept of pediatric emergency medicine (PEM) is virtually nonexistent in India. Suboptimally organized prehospital services substantially hinder the evaluation, management, and subsequent transport of the acutely ill and/or injured child to an appropriate facility. Furthermore, the management of the ill child at the hospital level is often provided by overburdened providers who, by virtue of their training, lack experience in the skills required to effectively manage pediatric emergencies. Finally, the care of the traumatized child often requires the involvement of providers trained in different specialities, which further impedes timely access to appropriate care...
December 2015: Indian Pediatrics
https://www.readbyqxmd.com/read/26661456/supersensitive-and-selective-detection-of-picric-acid-explosive-by-fluorescent-ag-nanoclusters
#18
Jian Rong Zhang, Yuan Yuan Yue, Hong Qun Luo, Nian Bing Li
Picric acid (PA) explosive is a hazard to public safety and health, so the sensitive and selective detection of PA is very important. In the present work, polyethyleneimine stabilized Ag nanoclusters were successfully used for the sensitive and selective quantification of PA on the basis of fluorescence quenching. The quenching efficiency of Ag nanoclusters is proportional to the concentration of PA and the logarithm of PA concentration over two different concentration ranges (1.0 nM-1 μM for the former and 0...
February 7, 2016: Analyst
https://www.readbyqxmd.com/read/26630004/upper-atmospheric-gravity-wave-details-revealed-in-nightglow-satellite-imagery
#19
Steven D Miller, William C Straka, Jia Yue, Steven M Smith, M Joan Alexander, Lars Hoffmann, Martin Setvák, Philip T Partain
Gravity waves (disturbances to the density structure of the atmosphere whose restoring forces are gravity and buoyancy) comprise the principal form of energy exchange between the lower and upper atmosphere. Wave breaking drives the mean upper atmospheric circulation, determining boundary conditions to stratospheric processes, which in turn influence tropospheric weather and climate patterns on various spatial and temporal scales. Despite their recognized importance, very little is known about upper-level gravity wave characteristics...
December 8, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26291651/an-ideal-detector-composed-of-two-dimensional-cd-ii-triazole-frameworks-for-nitro-compound-explosives-and-potassium-dichromate
#20
Ying Wang, Lin Cheng, Zheng-Yu Liu, Xiu-Guang Wang, Bo Ding, Long Yin, Bing-Bing Zhou, Ming-Shu Li, Jia-Xuan Wang, Xiao-Jun Zhao
The two-dimensional (2D) metal-organic framework (MOF) [Cd(TPTZ)(H2O)2(HCOOH)(IPA)2]n (1; TPTZ = {4-[4-(1H-1,2,4-triazol-1-yl)phenyl]phenyl}-1H-1,2,4-triazole, IPA = isophthalic acid) has been constructed with the π-electron-rich aromatic ligand TPTZ, auxiliary ligand IPA, and the metal Cd(2+) ion with a d(10) configuration under solvothermal conditions. Complex 1 exhibits a strong ligand-originated photoluminescence emission, which is selectively sensitive toward electron-deficient nitroaromatic compounds, such as nitrobenzene (NB), 1,3-dinitrobenzene (m-DNB), and 1,4-dinitrobenzene (p-DNB), and nitro-aliphatic compounds, such as nitromethane (NM) and tris(hydroxymethyl)nitromethane...
September 28, 2015: Chemistry: a European Journal
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