Emma Guilbaud, Thibault Barouillet, Marius Ilie, Coraline Borowczyk, Stoyan Ivanov, Vincent Sarrazy, Nathalie Vaillant, Marion Ayrault, Alexia Castiglione, Guylène Rignol, Patrick Brest, Venetia Bazioti, Konstantin Zaitsev, Kevin Lebrigand, Sébastien Dussaud, Virginie Magnone, Corine Bertolotto, Sandrine Marchetti, Marie Irondelle, Ira Goldberg, Thierry Huby, Marit Westerterp, Emmanuel L Gautier, Bernard Mari, Pascal Barbry, Paul Hofman, Laurent Yvan-Charvet
Cholesterol efflux pathways could be exploited in tumor biology to unravel cancer vulnerabilities. A mouse model of lung-tumor-bearing KRASG12D mutation with specific disruption of cholesterol efflux pathways in epithelial progenitor cells promoted tumor growth. Defective cholesterol efflux in epithelial progenitor cells governed their transcriptional landscape to support their expansion and create a pro-tolerogenic tumor microenvironment (TME). Overexpression of the apolipoprotein A-I, to raise HDL levels, protected these mice from tumor development and dire pathologic consequences...
June 1, 2023: Cell Stem Cell