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https://www.readbyqxmd.com/read/28915663/mir-223-3p-inhibits-angiogenesis-and-promotes-resistance-to-cetuximab-in-head-and-neck-squamous-cell-carcinoma
#1
Alexandre Bozec, Joséphine Zangari, Mathilde Butori-Pepino, Marius Ilie, Salomé Lalvee, Thierry Juhel, Catherine Butori, Patrick Brest, Paul Hofman, Valérie Vouret-Craviari
MicroRNAs (miRs) participate in tumor growth and dissemination by regulating expression of various target genes. MiR-223-3p is suspected of being involved in head and neck squamous cell carcinoma (HNSCC) growth although its precise role has not been elucidated. In this study, we showed that miR-223-3p is present in biopsies of HNSCC patients and that its presence is correlated with high neutrophil infiltrate. We found that overexpression of miR-223-3p slightly increased proliferation of the CAL27 squamous carcinoma cell line both in vitro and in vivo...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28882804/abcb1-and-abcc1-like-transporters-in-immune-system-cells-from-sea-urchins-echinometra-lucunter-and-echinus-esculentus-and-oysters-crassostrea-gasar-and-crassostrea-gigas
#2
Luis Fernando Marques-Santos, Hélène Hégaret, Leonardo Lima-Santos, Fernando Ramos Queiroga, Patricia Mirella da Silva
ABC transporters activity and expression have been associated with the multixenobiotic resistance phenotype (MXR). The activity of these proteins leads to a reduction in the intracellular concentration of several xenobiotics, thus reducing their toxicity. However, little attention has been given to the expression of ABC transporters in marine invertebrates and few studies have investigated their role in immune system cells of sea urchins and shellfish bivalves. The aim of the present study was to investigate the activity of the ABC transporters ABCB1 and ABCC1 in immune system cells of sea urchins (coelomocytes) and oysters (hemocytes) from different climatic regions (Brazil and France)...
September 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28723618/mir-223-3p-inhibits-angiogenesis-and-promotes-resistance-to-cetuximab-in-head-and-neck-squamous-cell-carcinoma
#3
Alexandre Bozec, Joséphine Zangari, Mathilde Butori-Pepino, Marius Ilie, Salomé Lalvee, Thierry Juhel, Catherine Butori, Patrick Brest, Paul Hofman, Valérie Vouret-Craviari
MicroRNAs (miRs) participate in tumor growth and dissemination by regulating expression of various target genes. MiR-223-3p is suspected of being involved in head and neck squamous cell carcinoma (HNSCC) growth although its precise role has not been elucidated. In this study, we showed that miR-223-3p is present in biopsies of HNSCC patients and that its presence is correlated with high neutrophil infiltrate. We found that overexpression of miR-223-3p slightly increased proliferation of the CAL27 squamous carcinoma cell line both in vitro and in vivo...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28688008/pneumocystis-jirovecii-and-cystic-fibrosis-in-brittany-france
#4
Gilles Nevez, Florence Robert-Gangneux, Laurence Pougnet, Michèle Virmaux, Chantal Belleguic, Eric Deneuville, Gilles Rault, Sylviane Chevrier, Sophie Ramel, Jean Le Bihan, Thibaud Guillaud-Saumur, Enrique Calderon, Yohann Le Govic, Jean-Pierre Gangneux, Solène Le Gal
Pneumocystis jirovecii is a transmissible fungus with a high pulmonary tropism. The prevalence of P. jirovecii in patients with cystic fibrosis (CF) has been estimated in Germany at 7.4%, in Spain at 21.5% and in Brazil at 38.2%. Data on the prevalence of P. jirovecii in CF patients in France remain scarce, particularly in Brittany, where the prevalence of CF is high (from 1/1600 to 1/4500). Our objectives were to determine the prevalence of colonization of the airways by P. jirovecii in Brittany in CF patients monitored at the "Centre de Ressources et de Compétences de la Mucoviscidose (CRCM)" of Rennes compared to that previously observed at the CRCM of Roscoff-Brest...
July 7, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28672757/hypercoiling-of-the-umbilical-cord-in-uncomplicated-singleton-pregnancies
#5
Marwan Ma'ayeh, Evan McClennen, Dmitri Chamchad, Michael Geary, Norman Brest, Andrew Gerson
BACKGROUND: The umbilical coiling index (UCI) is a measure of the number of coils in the umbilical cord in relation to its length. Hypercoiled cords with a UCI of >0.3 coils/cm have been associated with adverse fetal and neonatal outcomes. AIMS: The primary aim is to determine the accuracy of UCI measured on second trimester ultrasound in predicting UCI at birth. The secondary outcome is to investigate the association between hypercoiling of the umbilical cord on prenatal ultrasound and adverse maternal, fetal and neonatal outcomes...
June 26, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28569703/scholars-versus-practitioners-anchor-proof-testing-and-the-birth-of-a-mixed-culture-in-eighteenth-century-france
#6
Arnaud Orain, Sylvain Laubé
In line with studies that question the conventional dichotomies between "head" and "hand," this article analyzes the emergence of a mixed naval culture, between science and technology, during the French Enlightenment. The case at issue is that of the circuitous development of an anchor proof testing protocol, an important method in the competition for maritime supremacy used at least until the first third of the nineteenth century. The story begins in the dockyard of Brest with a humble boatswain, and continues with the dissemination of his experiments thanks to prominent figures of the Naval Academy of Brest and of the Royal Academy of Sciences of Paris...
2017: Technology and Culture
https://www.readbyqxmd.com/read/28450990/-anatomopathological-profile-of-breast-cancer-in-cape-bon-tunisia
#7
Ghada Sahraoui, Fatma Khanchel, Emna Chelbi
Breast cancer is the most common cancer among tunisian women and worldwide. In Cape Bon, Tunisia, the anatomopathological features of this cancer have not been established in previously published studies. Knowledge about these features is needed for the cultural adaptation of prevention and health care systems in the region. The aim of our study was to determine the pathological profile of breast cancers in the only public health anatomic pathology regional laboratory. We conducted a retrospective descriptive study of 116 patients who were diagnosed with breast cancers in our laboratory over a 5-year period, from July 2010 to July 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28431764/seasonal-monitoring-of-blue-mussel-mytilus-spp-populations-in-a-harbor-area-a-focus-on-responses-to-environmental-factors-and-chronic-contamination
#8
C Lacroix, E Duvieilbourg, N Guillou, J Guyomarch, C Bassoulet, D Moraga, G Chapalain, M Auffret
Coastal waters corresponding to macrotidal systems are among the most variable marine biotopes. Sessile animals as bivalve mollusks may however be found forming intertidal beds at high densities, as allowed by full adaptation to local conditions. A better knowledge of adaptive responses to environmental factors is required to foresee possible adverse effects of global change. At the sub-cellular level, transcriptional responses are among the earliest signals of environmental disturbances and they can reveal subtle and meaningful changes in organism exposed to stress...
August 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28371735/influence-of-environmental-and-anthropogenic-factors-on-the-composition-concentration-and-spatial-distribution-of-microplastics-a-case-study-of-the-bay-of-brest-brittany-france
#9
L Frère, I Paul-Pont, E Rinnert, S Petton, J Jaffré, I Bihannic, P Soudant, C Lambert, A Huvet
The concentration and spatial distribution of microplastics in the Bay of Brest (Brittany, France) was investigated in two surveys. Surface water and sediment were sampled at nine locations in areas characterized by contrasting anthropic pressures, riverine influences or water mixing. Microplastics were categorized by their polymer type and size class. Microplastic contamination in surface water and sediment was dominated by polyethylene fragments (PE, 53-67%) followed by polypropylene (PP, 16-30%) and polystyrene (PS, 16-17%) microparticles...
June 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28301973/beneficial-reuse-of-brest-harbor-france-dredged-sediment-as-alternative-material-in-road-building-laboratory-investigations
#10
Walid Maherzi, Mahfoud Benzerzour, Yannick Mamindy-Pajany, Eleanor van Veen, Mohamed Boutouil, Nor Edine Abriak
The scarcity of natural aggregates promotes waste reuse as secondary raw material in the field of civil engineering. This article focuses on the beneficial reuse of marine-dredged sediments in road building. Thus, mixtures of raw sediments and dredged sand collected from Brest Harbur (Bretagne, France) were treated with road hydraulic binders. Formulation were prepared and characterized as recommended by the French Technical Guidelines for soil treatment with lime and/or hydraulic binders. Mechanical resistance results are quite similar for both the hydraulic binders, suggesting a similar reactivity with the studied sediment sample...
April 9, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28253290/transcriptomic-features-of-pecten-maximus-oocyte-quality-and-maturation
#11
Marianna Pauletto, Massimo Milan, Arnaud Huvet, Charlotte Corporeau, Marc Suquet, Josep V Planas, Rebeca Moreira, Antonio Figueras, Beatriz Novoa, Tomaso Patarnello, Luca Bargelloni
The king scallop Pecten maximus is a high valuable species of great interest in Europe for both fishery and aquaculture. Notably, there has been an increased investment to produce seed for enhancement programmes of wild scallop populations. However, hatchery production is a relatively new industry and it is still underdeveloped. Major hurdles are spawning control and gamete quality. In the present study, a total of 14 scallops were sampled in the bay of Brest (Brittany, France) to compare transcriptomic profiles of mature oocytes collected by spawning induction or by stripping...
2017: PloS One
https://www.readbyqxmd.com/read/28073565/heterogeneous-distribution-in-sediments-and-dispersal-in-waters-of-alexandrium-minutum-in-a-semi-enclosed-coastal-ecosystem
#12
Z K Klouch, F Caradec, M Plus, T Hernández-Fariñas, L Pineau-Guillou, A Chapelle, S Schmitt, J Quéré, L Guillou, R Siano
Within the framework of research aimed at using genetic methods to evaluate harmful species distribution and their impact on coastal ecosystems, a portion of the ITS1rDNA of Alexandrium minutum was amplified by real-time PCR from DNA extracts of superficial (1-3cm) sediments of 30 subtidal and intertidal stations of the Bay of Brest (Brittany, France), during the winters of 2013 and 2015. Cell germinations and rDNA amplifications of A. minutum were obtained for sediments of all sampled stations, demonstrating that the whole bay is currently contaminated by this toxic species...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28046700/mo-de-207b-11-reliability-of-pet-ct-radiomics-features-in-functional-and-morphological-components-of-nsclc-lesions-a-repeatability-analysis-in-a-prospective-multicenter-cohort
#13
M Desseroit, F Tixier, M Majdoub, W Weber, B Siegel, C Cheze Le Rest, D Visvikis, M Hatt
PURPOSE: The goal of this study was to evaluate the repeatability of radiomics features (intensity, shape and heterogeneity) in both PET and low-dose CT components of test-retest FDG-PET/CT images in a prospective multicenter cohort of 74 NSCLC patients from ACRIN 6678 and a similar Merck trial. METHODS: Seventy-four patients with stage III-IV NCSLC were prospectively included. The primary tumor and up to 3 additional lesions per patient were analyzed. The Fuzzy Locally Adaptive Bayesian algorithm was used to automatically delineate metabolically active volume (MAV) in PET...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28003060/two-decades-of-pseudo-nitzschia-spp-blooms-and-king-scallop-pecten-maximus-contamination-by-domoic-acid-along-the-french-atlantic-and-english-channel-coasts-seasonal-dynamics-spatial-heterogeneity-and-interannual-variability
#14
Bérengère Husson, Tania Hernández-Fariñas, Romain Le Gendre, Mathilde Schapira, Annie Chapelle
King scallop contamination (Pecten maximus) by domoic acid, a neurotoxin produced by some species of the diatom Pseudo-nitzschia, is highly problematic because of its lengthy retention in the bivalve tissue, leading to prolonged fishery closures. Data collected within the French Phytoplankton and Phycotoxin monitoring network (REPHY) over the 1995-2012 period were used to characterize the seasonal dynamics and the interannual variability of P.-nitzschia spp. blooms as well as the contamination of king scallop fishing grounds, in six contrasted bays distributed along the French Atlantic coast and English Channel...
January 2016: Harmful Algae
https://www.readbyqxmd.com/read/27994032/rapid-decay-of-engulfed-extracellular-mirna-by-xrn1-exonuclease-promotes-transient-epithelial-mesenchymal-transition
#15
Joséphine Zangari, Marius Ilie, Florian Rouaud, Laurie Signetti, Mickaël Ohanna, Robin Didier, Barnabé Roméo, Dana Goldoni, Nicolas Nottet, Cathy Staedel, Jocelyn Gal, Bernard Mari, Baharia Mograbi, Paul Hofman, Patrick Brest
Extracellular vesicles (EVs) have been shown to play an important role in intercellular communication as carriers of DNA, RNA and proteins. While the intercellular transfer of miRNA through EVs has been extensively studied, the stability of extracellular miRNA (ex-miRNA) once engulfed by a recipient cell remains to be determined. Here, we identify the ex-miRNA-directed phenotype to be transient due to the rapid decay of ex-miRNA. We demonstrate that the ex-miR-223-3p transferred from polymorphonuclear leukocytes to cancer cells were functional, as demonstrated by the decreased expression of its target FOXO1 and the occurrence of epithelial-mesenchymal transition reprogramming...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27966928/arsenic-incorporation-in-pyrite-at-ambient-temperature-at-both-tetrahedral-s-i-and-octahedral-fe-ii-sites-evidence-from-exafs-dft-analysis
#16
Pierre Le Pape, Marc Blanchard, Jessica Brest, Jean-Claude Boulliard, Maya Ikogou, Lucie Stetten, Shuaitao Wang, Gautier Landrot, Guillaume Morin
Pyrite is a ubiquitous mineral in reducing environments and is well-known to incorporate trace elements such as Co, Ni, Se, Au, and commonly As. Indeed, As-bearing pyrite is observed in a wide variety of sedimentary environments, making it a major sink for this toxic metalloid. Based on the observation of natural hydrothermal pyrites, As(-I) is usually assigned to the occupation of tetrahedral S(-I) sites, with the same oxidation state as in arsenopyrite (FeAsS), although rare occurrences of As(III) and As(II) have been reported...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27918166/-breast-self-examination-yes-or-no
#17
REVIEW
P Šašková, D Pavlišta
OBJECTIVE: The rising number of breast cancer is the worldwide problem. The screening mammography is considered as the most effective method to decrease the mortality of the disease. For many years, the breast self-examination has been promoted as the simplest method for breast cancer development in women. In this review article, we provide the results of studies on the effectiveness of breast self-examination. DESIGN: Review article. SETTING: Departmnet of Gynecologic and Obstetrition, General Faculty Hospital and 1st Faculty of Medicine, Charles University Prague...
December 0: Ceská Gynekologie
https://www.readbyqxmd.com/read/27848922/zika-virus-infection
#18
Laurence Pougnet, Chloé Thill, Richard Pougnet, Henri Auvinet, Christophe Giacardi, Isabelle Drouillard
A 21-year old woman from New-Caledonia had 40 ̊C fever with vomiting, arthralgia, myalgia, and measles-like rash. Etiological analyses showed primary infection with Zika virus. Because of severe clinical presentation, she was hospitalized in the intensive care unit of the Brest military Hospital. Zika virus is mainly transmitted by Aedes mosquitoes. If they settle in Metropolitan France, Zika virus might also spread there.
December 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27796018/-adpkd-predictors-of-renal-disease-progression
#19
Francesco Scolari, Nadia Dallera, Arianna Saletti, Vincenzo Terlizzi, Claudia Izzi
Factors predicting rapid progression of kidney disease in ADPKD can be divided into genetic (non-modifiable) and clinical (modifiable) risk factors. Patients harbouring PKD1 mutations, in particular if truncating, have a more severe form of ADPKD. Clinical risk factors include decrease in glomerular filtration rate and renal blood flow at a young age; high total kidney volume; hypertension and urological complications <35 years; albuminuria/proteinuria. The renal disease is also more severe in males and in subjects with family history of ESRD <55 years...
September 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/27721211/the-utilisation-of-the-cardiovascular-automated-radiation-reduction-x-ray-system-cars-in-the-cardiac-catheterisation-laboratory-aids-in-the-reduction-of-the-patient-radiation-dose
#20
Romain Didier, Marco A Magalhaes, Edward Koifman, Florent Leven, Philippe Castellant, Jacques Boschat, Yannic Jobic, Sarkis Kiramijyan, Pierre-Philippe Nicol, Martine Gilard
AIMS: The radiation exposure resulting from cardiovascular procedures may increase the risk of cancer, and/or cause skin injury. Whether the novel cardiovascular automated radiation reduction X-ray system (CARS) can help reduce the patient radiation dose in daily clinical practice remains unknown. The aim of this study was to evaluate the reduction in patient radiation dose with the use of CARS in the cardiac catheterisation laboratory (CCL). METHODS AND RESULTS: This study retrospectively analysed 1,403 consecutives patients who underwent a cardiac catheterisation with coronary angiography (CA) and/or a percutaneous coronary intervention (PCI) in the Brest University Hospital over the course of one year...
October 10, 2016: EuroIntervention
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