keyword
https://read.qxmd.com/read/37516330/clinical-efficacy-and-safety-of-bempedoic-acid-in-high-cardiovascular-risk-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#21
REVIEW
Naseer Uddin, Abdul Ahad Syed, Syed Muhammad Ismail, Muhammad Talal Ashraf, Muhammad Khuzzaim Khan, Affan Sohail
Bempedoic acid (BA) is the new addition to lipid-lowering medications. This systematic review and meta-analysis of randomized controlled trials (RCTs) assess the clinical efficacy and safety of BA in high cardiovascular (CV) risk patients along with its effects on low-density lipoprotein cholesterol (LDL-C) and total cholesterol. PubMed, Google Scholar, Cochrane Central Register of Controlled Trials, Embase, and ClinicalTrials.gov were searched for RCTs comparing BA with placebo, reporting CV outcomes. Seven RCTs with a total of 17,816 patients were selected for the analysis...
July 27, 2023: Current Problems in Cardiology
https://read.qxmd.com/read/37511046/coronary-microvascular-dysfunction-evolving-understanding-of-pathophysiology-clinical-implications-and-potential-therapeutics
#22
REVIEW
Chun Yeung Kei, Kuljit Singh, Rustem F Dautov, Thanh H Nguyen, Yuliy Y Chirkov, John D Horowitz
Until recently, it has been generally held that stable angina pectoris (SAP) primarily reflects the presence of epicardial coronary artery stenoses due to atheromatous plaque(s), while acute myocardial infarction (AMI) results from thrombus formation on ruptured plaques. This concept is now challenged, especially by results of the ORBITA and ISCHEMIA trials, which showed that angioplasty/stenting does not substantially relieve SAP symptoms or prevent AMI or death in such patients. These disappointing outcomes serve to redirect attention towards anomalies of small coronary physiology...
July 10, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37503661/exact-trial-results-of-the-phase-1-dose-escalation-study
#23
JOURNAL ARTICLE
Thomas J Povsic, Timothy D Henry, Jay H Traverse, R David Anderson, Geoffrey A Answini, Benjamin C Sun, George J Arnaoutakis, Konstantinos D Boudoulas, Adam R Williams, Howard C Dittrich, Elizabeth A Tarka, David A Latter, E Magnus Ohman, Mark W Peterson, Dawn Byrnes, Carl J Pepine, Marcelo F DiCarli, Ronald G Crystal, Todd K Rosengart, Nahush A Mokadam
BACKGROUND: New therapies are needed for patients with refractory angina. Encoberminogene rezmadenovec (XC001), a novel adenoviral-5 vector coding for all 3 major isoforms of VEGF (vascular endothelial growth factor), demonstrated enhanced local angiogenesis in preclinical models; however, the maximal tolerated dose and safety of direct epicardial administration remain unknown. METHODS: In the phase 1 portion of this multicenter, open-label, single-arm, dose-escalation study, patients with refractory angina received increasing doses of encoberminogene rezmadenovec (1×109 , 1×1010 , 4×1010 , and 1×1011 viral particles) to evaluate its safety, tolerability, and preliminary efficacy...
July 28, 2023: Circulation. Cardiovascular Interventions
https://read.qxmd.com/read/37476333/spinal-cord-stimulation-for-refractory-pericarditis-a-case-report-and-a-review-of-the-mechanism-of-action
#24
Simon Elsliger, Jacob Saucier, Andre Schneider, Antonios El Helou
BACKGROUND AND OBJECTIVES: In recent years, spinal cord stimulation (SCS) has emerged as a promising management option for chronic pain of multiple etiologies. While its effectiveness has been strongly suggested in many patients, the exact mechanism of action of SCS is incompletely understood. This article reviews the leading mechanisms underlying the analgesic and cardiovascular effects of SCS and reports its novel benefits in a case of recurrent pericarditis. LITERATURE REVIEW: Throughout history, the analgesic properties of SCS were thought to arise via stimulation of the spinothalamic tract...
2023: Front Pain Res (Lausanne)
https://read.qxmd.com/read/37468198/burst-stimulation-for-refractory-angina-pectoris
#25
JOURNAL ARTICLE
Daehun Yun, Kaehong Lee, Ji Soo Kwak, Leegyeong Je, Taesan Kim, Yoon Sun Park, Jae Chul Koh
Refractory angina pectoris (RAP) is a chronic, severe chest pain associated with coronary artery disease that cannot be resolved using optimal medical or surgical approaches. Spinal cord stimulation (SCS) is a suitable treatment option. Conventional waveforms of SCS have shown a potent effect on the tempering of RAP. However, SCS is associated with undesired paresthesia. The new burst SCS waveforms have been reported to have fewer adverse effects. We reviewed a case in which RAP was successfully treated with burst SCS in a middle-aged man, with a tonic waveform employed for breakthrough pain as needed...
July 14, 2023: Anesthesia and pain medicine
https://read.qxmd.com/read/37445311/associations-between-liver-enzymes-lifestyle-risk-factors-and-pre-existing-medical-conditions-in-a-population-based-cross-sectional-sample
#26
JOURNAL ARTICLE
Onni Niemelä, Aini Bloigu, Risto Bloigu, Mauri Aalto, Tiina Laatikainen
While alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) enzymes are commonly used indicators of liver dysfunction recent studies have suggested that these may also serve as predictive biomarkers in the assessment of extrahepatic morbidity. In order to shed further light on the interactions between serum liver enzyme abnormalities, factors of lifestyle and health status we examined ALT and GGT activities in a population-based sample of 8743 adult individuals (4048 men, 4695 women from the National FINRISK 2002 Study, mean age 48...
June 26, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37378305/vieussens-arterial-ring-historical-background-medical-review-and-novel-anatomical-classification
#27
REVIEW
Konstantinos C Christodoulou, Dimitrios Stakos, Vassiliki Androutsopoulou, Maria Chourmouzi-Papadopoulou, Gregory Tsoucalas, Dimos Karangelis, Aliki Fiska
In coronary artery disease, the presence of Vieussens' arterial ring (VAR), a ring-shaped anastomosis between the conus branch of the right coronary artery with the left anterior descending artery (LAD), will allow blood flow to return to the obstructed coronary system. We have conducted a literature review, aiming to collect all the existing information about the documented VAR cases and any related pathological conditions. A total of 54 studies entered the review, including 56 patients. The mean age of the patients was 56...
June 2023: Curēus
https://read.qxmd.com/read/37367400/effect-of-coronary-sinus-reducer-implantation-on-aerobic-exercise-capacity-in-refractory-angina-patients-a-crossroad-study
#28
JOURNAL ARTICLE
Miha Mrak, Nejc Pavšič, David Žižek, Luka Ležaić, Matjaž Bunc
Coronary sinus reducer (CSR) implantation is a new treatment option for patients with refractory angina pectoris. However, there is no evidence from a randomized trial that would show an improvement in exercise capacity after this treatment. The aim of this study was to evaluate the influence of CSR treatment on maximal oxygen consumption and compare it to a sham procedure. Twenty-five patients with refractory angina pectoris (Canadian Cardiovascular Society (CCS) class II-IV) were randomized to a CSR implantation ( n = 13) or a sham procedure ( n = 12)...
May 26, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37294714/machine-learning-algorithm-can-provide-assistance-for-the-diagnosis-of-non-st-segment-elevation-myocardial-infarction
#29
JOURNAL ARTICLE
Lian Qin, Quan Qi, Ainiwaer Aikeliyaer, Wen Qing Hou, Chang Xin Zuo, Xiang Ma
INTRODUCTION: Our aim was to use the constructed machine learning (ML) models as auxiliary diagnostic tools to improve the diagnostic accuracy of non-ST-elevation myocardial infarction (NSTEMI). MATERIALS AND METHODS: A total of 2878 patients were included in this retrospective study, including 1409 patients with NSTEMI and 1469 patients with unstable angina pectoris. The clinical and biochemical characteristics of the patients were used to construct the initial attribute set...
June 8, 2023: Postgraduate Medical Journal
https://read.qxmd.com/read/37262420/cardiovascular-events-after-elective-colorectal-cancer-surgery-in-patients-with-stage-i-iii-disease-with-no-previous-cardiovascular-disease
#30
JOURNAL ARTICLE
Thea Helene Degett, Ida Rask Moustsen-Helms, Signe Benzon Larsen, Trille Kristina Kjær, Anne Tjønneland, Susanne Krüger Kjær, Christoffer Johansen, Ismail Gögenur, Susanne Oksbjerg Dalton
BACKGROUND: The risk of cardiovascular events in patients treated for colorectal cancer is debated due to diverging results in previous studies. Colorectal cancer and cardiovascular disease share several risk factors such as physical inactivity, obesity, and smoking. Information about confounding covariates and follow-up time are therefore essential to address the issue. This study aims to investigate the risk of new-onset cardiovascular events for patients with stage I-III colorectal cancer receiving elective surgery compared to a matched population...
June 1, 2023: Acta Oncologica
https://read.qxmd.com/read/37132104/redefining-the-roles-of-aspirin-across-the-spectrum-of-cardiovascular-disease-prevention
#31
JOURNAL ARTICLE
Matthew T Brown, Kristina S Bortfeld, Laurence S Sperling, Nanette K Wenger
Even before its role in platelet inhibition was fully characterized in the 1980s, aspirin had been incorporated into the cardiovascular disease care algorithm. Early trials examining its use in unstable angina and acute myocardial infarction revealed evidence of its protective role in the secondary prevention of atherosclerotic cardiovascular disease (ASCVD). Large trials assessing use in the primary prevention setting and optimal dosing regimens were studied in the late 1990s and early 2000s. As a cornerstone of cardiovascular care, aspirin was incorporated into primary and secondary ASCVD prevention guidelines in the United States and mechanical heart valve guidelines...
2023: Current Cardiology Reviews
https://read.qxmd.com/read/37101608/cost-effectiveness-of-icosapent-ethyl-ipe-for-the-reduction-of-the-risk-of-ischemic-cardiovascular-events-in-canada
#32
JOURNAL ARTICLE
Jean Lachaine, Jean-Nicolas Charron, Jean C Gregoire, Robert A Hegele, Lawrence A Leiter
BACKGROUND: Despite the use of statins, many patients with cardiovascular disease (CVD) have persistent residual risk. In a large Phase III trial (REDUCE-IT), icosapent ethyl (IPE) was shown to reduce the first occurrence of the primary composite endpoint of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or hospitalization for unstable angina. METHODS: We conducted a cost-utility analysis comparing IPE to placebo in statin-treated patients with elevated triglycerides, from a publicly funded, Canadian healthcare payer perspective, using a time-dependent Markov transition model over a 20-year time horizon...
2023: ClinicoEconomics and Outcomes Research: CEOR
https://read.qxmd.com/read/37051483/reversible-unstable-abdominal-angina-caused-by-ruptured-plaque-of-the-superior-mesenteric-artery-clinical-and-radiological-correlations
#33
JOURNAL ARTICLE
Shaul Yaari, Nurith Hiller, Yacov Samet, Samuel N Heyman
UNLABELLED: Unstable angina, characteristic of coronary artery disease, is caused by in-situ clot formation complicating ruptured atheromatous plaque. Abdominal angina, however, usually reflects chronic mesenteric ischaemia, caused by multi-vessel stable plaques involving mesenteric arteries. Herein, we describe a patient with new-onset abdominal pain caused by a ruptured atheromatous plaque at the superior mesenteric root. The diagnosis was based on an evident reversible epigastric bruit and high-degree eccentric stenosis caused by a non-calcified atheroma...
2023: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/37027156/cardiovascular-outcomes-and-mortality-after-bariatric-surgery-in-patients-with-nonalcoholic-fatty-liver-disease-and-obesity
#34
JOURNAL ARTICLE
Arunkumar Krishnan, Yousaf Hadi, Saleh A Alqahtani, Tinsay A Woreta, Wei Fang, Salim Abunnaja, Nova Szoka, Lawrence E Tabone, Shyam Thakkar, Shailendra Singh
IMPORTANCE: Bariatric surgery (BS) is associated with significantly reduced incidence of cardiovascular diseases and mortality in patients with obesity. However, whether BS can decrease major adverse cardiovascular events in patients with nonalcoholic fatty liver disease (NAFLD) remains poorly understood. OBJECTIVE: To investigate the association of BS with the incidence of adverse cardiovascular events and all-cause mortality in patients with NAFLD and obesity...
April 3, 2023: JAMA Network Open
https://read.qxmd.com/read/37020262/right-bundle-branch-block-evolving-to-myocardial-ischemia-in-a-patient-with-chronic-middle-back-pain-a-case-report
#35
JOURNAL ARTICLE
Meity Ardiana, Inna Maya Sufiyah, Muhammad Nuh Hamdani
BACKGROUND: A right bundle branch block (RBBB) is rarely found in patients with myocardial infarction (MI). In addition, back pain is an atypical complaint in patients with angina. CASE: A 77-year-old Javanese male was admitted with middle back pain that he had had for several months but that had become worse in the past week. He received an oral nonsteroidal anti-inflammatory drug as analgesic therapy but the pain did not improve. The patient came to the emergency room and an electrocardiogram (ECG) showed complete RBBB and first-degree atrioventricular block...
April 6, 2023: Journal of Medical Case Reports
https://read.qxmd.com/read/36988260/the-potential-role-of-sars-cov-2-infection-in-acute-coronary-syndrome-and-type-2-myocardial-infarction-t2mi-intertwining-spread
#36
REVIEW
Aseel Awad Alsaidan, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Khalid Adel Alsayed, Hebatallah M Saad, Gaber El-Saber Batiha
Coronavirus disease 2019 (COVID-19) is a novel pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has been shown that SARS-CoV-2 infection-induced inflammatory and oxidative stress and associated endothelial dysfunction may lead to the development of acute coronary syndrome (ACS). Therefore, this review aimed to ascertain the link between severe SARS-CoV-2 infection and ACS. ACS is a spectrum of acute myocardial ischemia due to a sudden decrease in coronary blood flow, ranging from unstable angina to myocardial infarction (MI)...
March 2023: Immunity, Inflammation and Disease
https://read.qxmd.com/read/36982519/eptifibatide-an-older-therapeutic-peptide-with-new-indications-from-clinical-pharmacology-to-everyday-clinical-practice
#37
REVIEW
Gašper Tonin, Jasna Klen
Therapeutic peptides are oligomers or short polymers of amino acids used for various medical purposes. Peptide-based treatments have evolved considerably due to new technologies, stimulating new research interests. They have been shown to be beneficial in a variety of therapeutic applications, notably in the treatment of cardiovascular disorders such as acute coronary syndrome (ACS). ACS is characterized by coronary artery wall damage and consequent formation of an intraluminal thrombus obstructing one or more coronary arteries, leading to unstable angina, non-ST elevated myocardial infarction, and ST-elevated myocardial infarction...
March 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36982284/nanoparticles-in-the-new-era-of-cardiovascular-therapeutics-challenges-and-opportunities
#38
REVIEW
Pingping Yang, Jun Ren, Lifang Yang
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although a cadre of therapeutic strategies have been made available for CVDs in the clinical setting, predominantly through medication and surgery, these do not fully address the clinical needs of patients with CVD. As a new technique for CVD treatment, nanocarriers are employed to modify and package medications to ease the targeting of tissues, cells and molecules within the cardiovascular system. Nanocarriers are made of biomaterials, metals, or a combination of these materials, with sizes similar to bioactive molecules such as proteins and DNA...
March 8, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36777824/re-catheterization-in-a-young-patient-with-acute-myocardial-infarction-is-it-preventable
#39
JOURNAL ARTICLE
Fatemeh M Hazin, Dawood Jamil, Charu Sharma, Javed Yasin, Gohar Jamil, Juma Alkaabi
Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. The goal of our study was to determine the causes of re-catheterization in a young population who were admitted with myocardial infarction and previously underwent cardiac catheterization, and determine what measures can be applied to prevent their re-catheterization. A retrospective study was conducted at Tawam hospital for 6 years (2009-2014). 50 patients between 18 and 50 years of age admitted with acute coronary syndrome who had re-catheterization within a year from their first cardiac catheterization were included...
2023: American Journal of Translational Research
https://read.qxmd.com/read/36737594/clinical-characteristics-treatment-patterns-and-effectiveness-in-chinese-patients-with-angina-pectoris-using-electronic-patient-reported-outcomes-protocol-for-a-multicenter-prospective-cohort-study-great
#40
JOURNAL ARTICLE
Xiliang Zhao, Zichuan Tong, Liling Sun, Qihua Zhang, Xin Du, Su'e Xu, Chengning Shen, Ying Wei, Wei Liu, Lifu Miao, Yong Zeng
BACKGROUND: Angina pectoris (AP) is the initial and the most common manifestation of coronary artery disease (CAD). Therefore, management and control of AP can help prevent further complications associated with CAD. However, there is under-reporting of angina symptoms in clinical practice, resulting in under-treatment and reduced quality of life (QoL). Prospective and standardized monitoring is needed to support timely and appropriate treatment. OBJECTIVES: To establish a large cohort of Chinese patients with AP and compare the effectiveness of different anti-angina regimens with the help of electronic patient-reported outcomes (e-PROs), using the Seattle Angina Questionnaire (SAQ) to assess health status...
February 4, 2023: Advances in Therapy
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