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Aldosteronism

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https://www.readbyqxmd.com/read/29244537/role-of-renin-angiotensin-aldosterone-system-on-short-term-blood-pressure-variability-in-hypertensive-patients
#1
Minako Inoue, Kiyoshi Matsumura, Yoshie Haga, Yasuo Kansui, Kenichi Goto, Toshio Ohtsubo, Takanari Kitazono
The relationship between the renin-angiotensin aldosterone system and short-term blood pressure variability has not been well elucidated. Here, we investigated whether blood pressure variability determined by ambulatory blood pressure monitoring differed among patients with primary aldosteronism (PA), renovascular hypertension (RVHT), and essential hypertension (EHT). We examined 25 patients with PA, 28 patients with RVHT, and 18 patients with EHT. Ambulatory blood pressure monitoring was conducted in all patients...
December 15, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29244531/effects-of-natural-peptides-from-food-proteins-on-angiotensin-converting-enzyme-activity-and-hypertension
#2
Melanie Martin, Andreas Deussen
Cardiovascular diseases are the leading cause of death. The underlying pathophysiology is largely contributed by an overactivation of the renin-angiotensin-aldosterone-system (RAAS). Herein, angiotensin II (AngII) is a key mediator not only in blood pressure control and vascular tone regulation, but also involved in inflammation, endothelial dysfunction, atherosclerosis, hypertension and congestive heart failure. Since more than three decades suppression of AngII generation by inhibition of the angiotensin-converting enzyme (ACE) or blockade of the AngII-receptor has shown clinical benefit by reducing hypertension, atherosclerosis and other inflammation-associated cardiovascular diseases...
December 15, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29243497/preventing-recurrent-events-in-survivors-of-acute-coronary-syndromes-in-australia-consensus-recommendations-using-the-delphi-process
#3
Christopher J Hammett, John Amerena, David Brieger, Andrew Sindone, Peter L Thompson, Matthew I Worthley, Philip E Aylward
OBJECTIVE: There remain substantial gaps in implementation of evidence-based care in patients with acute coronary syndromes (ACS) in Australia, which contribute to high recurrent event rates. Improved translation of evidence into effective action is a key health-care priority. We engaged cardiovascular experts from across Australia to develop straightforward, easily actionable recommendations on key medications to use following ACS. METHODS: An eight-person steering committee (SC) reviewed the published evidence and developed an initial set of statements to be developed into consensus recommendations using a modified Delphi technique...
December 15, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29240788/enhanced-heart-failure-mortality-and-renin-activation-in-female-mice-with-experimental-dilated-cardiomyopathy
#4
Ranjana Tripathi, Ryan Sullivan, Tai-Hwang M Fan, Dong Wang, Yao Sun, Guy L Reed, Inna P Gladysheva
Dilated cardiomyopathy (DCM) is the major cause of heart failure affecting both women and men. Limited clinical studies show conflicting data in sex-related differences in the progression of dilated cardiomyopathy and heart failure (HF) outcomes. We examined the comparative sex-related progression of cardiomyopathy and the development of HF (at 4, 7, 13 weeks of age) in a well-established, transgenic mouse model of DCM that recapitulates the progressive stages of human HF. By 13 weeks of age, female mice with DCM had more severe left ventricular systolic dysfunction, left ventricular dilation and wall thinning (P<0...
2017: PloS One
https://www.readbyqxmd.com/read/29240784/effects-of-calcium-channel-blockers-comparing-to-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-in-patients-with-hypertension-and-chronic-kidney-disease-stage-3-to-5-and-dialysis-a-systematic-review-and-meta-analysis
#5
Yen-Chung Lin, Jheng-Wei Lin, Mai-Szu Wu, Kuan-Chou Chen, Chiung-Chi Peng, Yi-No Kang
BACKGROUND: Calcium channel blocker (CCB) or two renin angiotensin aldosterone system blockades (RAAS), angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are major potent and prevalently used as initial antihypertensive agents for mild to moderate hypertension, but no uniform agreement as to which antihypertensive drugs should be given for initial therapy, especially among chronic kidney disease (CKD) patients. DESIGN: A systematic review and meta-analysis comparing CCBs and the two RAAS blockades for hypertensive patients with CKD stage 3 to 5D...
2017: PloS One
https://www.readbyqxmd.com/read/29238437/persistent-primary-aldosteronism-despite-iatrogenic-adrenal-hemorrhage-after-adrenal-vein-sampling
#6
Keisuke Okamura, Tetsu Okuda, Kazuyuki Shirai, Ichiro Abe, Kunihisa Kobayashi, Tatsu Ishii, Seiji Haraoka, Hidenori Urata
Before surgery for primary aldosteronism (PA), localization is evaluated with adrenal vein sampling (AVS). A 56-year-old Japanese woman had a right adrenal mass, hypokalemia, and a high aldosterone/renin ratio. Stress tests confirmed the diagnosis of PA. Subsequently, preoperative AVS was performed and right adrenal hemorrhage (AH) occurred unexpectedly. Because hypertension persisted, laparoscopic right adrenalectomy was performed. Postoperatively, the blood pressure was normalized. Pathological examination revealed an adrenal cortical adenoma largely unaffected by necrosis and hemorrhage...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29238435/primary-aldosteronism-with-type-2-diabetes-mellitus-requires-more-antihypertensive-drugs-for-blood-pressure-control-a-retrospective-observational-study
#7
Kennosuke Ohashi, Takeshi Hayashi, Yui Watanabe, Koichiro Hara, Rikako Ukichi, Hiroshi Asano, Hirofumi Suzuki, Kenji Yamashiro, Katsuyoshi Tojo, Masaya Sakamoto, Kazunori Utsunomiya
Background: Diabetes mellitus (DM) and primary aldosteronism (PA) have been reported to induce drug-resistant hypertension and atherosclerosis. It is likely that blood pressure (BP) control becomes far more difficult in PA patients with DM. However, precise clinical characteristics of PA with type 2 DM especially in the aspect of BP control are not clear. Methods: The study included 18 patients who were diagnosed as PA with DM and 52 PA patients without DM who matched age and sex and chosen as a control group...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29238217/effects-of-voluntary-exercise-on-blood-pressure-angiotensin-ii-aldosterone-and-renal-function-in-two-kidney-one-clip-hypertensive-rats
#8
Brian M Waldman, Robert A Augustyniak, Haiping Chen, Noreen F Rossi
Spontaneous dynamic exercise promotes sympathoinhibition and decreases arterial pressure in two-kidney, one-clip (2K-1C) hypertensive rats. Renal sympathetic nerves stimulate renin secretion and increase renal tubular sodium reabsorption. We hypothesized that daily voluntary wheel running exercise by 2K-1C rats will decrease mean arterial pressure (MAP), plasma angiotensin II (Ang II), and aldosterone as well as normalize urinary sodium and potassium excretion independent of changes in glomerular filtration rate (GFR)...
2017: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/29237697/triple-a-syndrome-a-wide-spectrum-of-adrenal-dysfunction
#9
Florence Roucher-Boulez, Aude Brac de la Perrière, Aude Jacquez, Delphine Chau, Laurence Guignat, Christophe Vial, Yves Morel, Marc Nicolino, Gerald Raverot, Michel Pugeat
Objective: Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the AAAS gene which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: Alacrima, Achalasia and Adrenal Insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients. Methods: A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center...
December 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29237382/renin-activity-and-aldosterone-assay-among-nigerians-with-hypertension-and-normotension-an-insight-into-normative-values-and-clinical-correlates
#10
Adeseye Abiodun Akintunde, Afolabi Salawu, Boluwatife Adeniyi
OBJECTIVES: Plasma renin activity (PRA) and aldosterone tend to differ between Blacks and Caucasians and studies are very scarce among Africans. We therefore aimed to determine the normative value of plasma renin activity and serum aldosterone among school teachers in Nigeria with normal blood pressure compared with their hypertensive counterparts and relevant clinical/demographic associations. METHODS: Plasma renin activity and serum aldosterone were measured using the kits provided by Diagnostic Biochem, Canada among randomly selected school teachers recruited as part of a study to assess their total cardiovascular risks...
December 13, 2017: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29234376/roles-of-nitric-oxide-and-prostaglandins-in-the-sustained-antihypertensive-effects-of-acanthospermum-hispidum-dc-on-ovariectomized-rats-with-renovascular-hypertension
#11
Rhanany Alan Calloi Palozi, Maysa Isernhagen Schaedler, Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Francislaine Aparecida Dos Reis Lívero, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Thiago Bruno Lima Prando, Lauro Mera de Souza, Arquimedes Gasparotto Junior
Although Acanthospermum hispidum is used in Brazilian folk medicine as an antihypertensive, no study evaluated its effects on a renovascular hypertension and ovariectomy model. So, this study investigated the mechanisms involved in the antihypertensive effects of an ethanol-soluble fraction obtained from A. hispidum (ESAH) using two-kidney-one-clip hypertension in ovariectomized rats (2K1C plus OVT). ESAH was orally administered at doses of 30, 100, and 300 mg/kg, daily, for 28 days, after 5 weeks of surgery...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233053/evaluation-of-a-pharmacist-driven-aldosterone-antagonist-stewardship-program-in-patients-with-heart-failure
#12
Eric R Sparks, Janna C Beavers
OBJECTIVE: To evaluate the impact of a pharmacist-driven initiative to optimize aldosterone antagonist use in patients with heart failure with reduced ejection fraction (HFrEF) at a large community hospital. METHODS: This single-center, retrospective cohort study compared patients with heart failure before and after the implementation of the initiative. Data for pre- and postinitiative patients were retrospectively collected to assess patient characteristics and aldosterone antagonist use...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29230301/localized-herpes-zoster-infection-a-rare-cause-of-syndrome-of-inappropriate-secretion-of-antidiuretic-hormone
#13
V Bassi, O Fattoruso, C Santinelli
Hyponatremia is the most common electrolyte abnormality observed in clinical practice and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is diagnosed in nearly 40% of the hospitalized hyponatremic patients. We present a case report of herpes zoster infection causing a severe hyponatremia/hypokalemia. This rare association between SIADH and varicella-zoster virus infection is described in only few case in the literature. In our case report, the associated hypokalemia was not related to the use of diuretics but, probably, dependent on the frank serum hyposmolality able to induce an aldosterone release...
November 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29230292/multiple-steroid-and-thyroid-hormones-detected-in-baleen-from-eight-whale-species
#14
Kathleen E Hunt, Nadine S Lysiak, Jooke Robbins, Michael J Moore, Rosemary E Seton, Leigh Torres, C Loren Buck
Recent studies have demonstrated that some hormones are present in baleen powder from bowhead (Balaena mysticetus) and North Atlantic right (Eubalaena glacialis) whales. To test the potential generalizability of this technique for studies of stress and reproduction in large whales, we sought to determine whether all major classes of steroid and thyroid hormones are detectable in baleen, and whether these hormones are detectable in other mysticetes. Powdered baleen samples were recovered from single specimens of North Atlantic right, bowhead, blue (Balaenoptera [B...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/29229748/adrenal-vein-sampling-is-the-preferred-method-to-select-patients-with-primary-aldosteronism-for-adrenalectomy-con-side-of-the-argument
#15
Jaap Deinum, Aleksander Prejbisz, Jacques W M Lenders, Gert Jan van der Wilt
No abstract text is available yet for this article.
January 2018: Hypertension
https://www.readbyqxmd.com/read/29229745/aging-and-adrenal-aldosterone-production
#16
REVIEW
Kazutaka Nanba, Anand Vaidya, William E Rainey
No abstract text is available yet for this article.
December 11, 2017: Hypertension
https://www.readbyqxmd.com/read/29229742/adrenal-vein-sampling-is-the-preferred-method-to-select-patients-with-primary-aldosteronism-for-adrenalectomy-pro-side-of-the-argument
#17
Gian Paolo Rossi, John W Funder
No abstract text is available yet for this article.
December 11, 2017: Hypertension
https://www.readbyqxmd.com/read/29227582/role-of-the-sodium-hydrogen-exchanger-in-mediating-the-renal-effects-of-drugs-commonly-used-in-the-treatment-of-type-2-diabetes
#18
REVIEW
Milton Packer
Diabetes is characterized by an increased activity of the sodium-hydrogen exchanger (NHE) in the glomerulus and renal tubules, which contributes importantly to the development of nephropathy. Despite the established role played by the exchanger in experimental studies, it has not been specifically targeted by those seeking to develop novel pharmacological treatments for diabetes. This review demonstrates that many existing drugs that are commonly prescribed to patients with diabetes act on the NHE1 and NHE3 isoforms in the kidney...
December 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29226122/does-mineralocorticoid-receptor-antagonism-prevent-calcineurin-inhibitor-induced-nephrotoxicity
#19
REVIEW
Line Aas Mortensen, Claus Bistrup, Helle Charlotte Thiesson
Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial fibrosis and tubular atrophy, which impairs long-term allograft survival. The mineralocorticoid hormone aldosterone induces fibrosis in numerous organs, including the kidney. Evidence from animal models suggests a beneficial effect of aldosterone antagonism in reducing calcineurin inhibitor-induced nephrotoxicity...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29225804/angiotensinogen-as-a-biomarker-of-acute-kidney-injury
#20
REVIEW
Sheeba Habeeb Ba Aqeel, Alejandro Sanchez, Daniel Batlle
Early recognition of acute kidney injury (AKI) is critical to prevent its associated complications as well as its progression to long term adverse outcomes like chronic kidney disease. A growing body of evidence from both laboratory and clinical studies suggests that inflammation is a key factor contributing to the progression of AKI regardless of the initiating event. Biomarkers of inflammation are therefore of interest in the evaluation of AKI pathogenesis and prognosis. There is evidence that the renin angiotensin aldosterone system is activated in AKI, which leads to an increase in angiotensin II (Ang II) formation within the kidney...
December 2017: Clinical Kidney Journal
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