keyword
https://read.qxmd.com/read/37681985/a-genetic-selection-for-mycobacterium-smegmatis-mutants-tolerant-to-killing-by-sodium-citrate-defines-a-combined-role-for-cation-homeostasis-and-osmotic-stress-in-cell-death
#21
JOURNAL ARTICLE
John T Williams, Jacob J Baker, Huiqing Zheng, Shelby J Dechow, Jared Fallon, Megan Murto, Veronica J Albrecht, Haleigh N Gilliland, Andrew J Olive, Robert B Abramovitch
Mycobacteria can colonize environments where the availability of metal ions is limited. Biological or inorganic chelators play an important role in limiting metal availability, and we developed a model to examine Mycobacterium smegmatis survival in the presence of the chelator sodium citrate. We observed that instead of restricting M. smegmatis growth, concentrated sodium citrate killed M. smegmatis . RNAseq analysis during sodium citrate treatment revealed transcriptional signatures of metal starvation and hyperosmotic stress...
September 8, 2023: MSphere
https://read.qxmd.com/read/37644997/management-of-a-patient-with-premenstrual-syndrome-using-acupuncture-supplements-and-meditation-a-case-report
#22
Brett R Martin, Jade Woodruff
OBJECTIVE: The purpose of this case report was to describe a multimodal approach for the treatment of premenstrual syndrome (PMS). CLINICAL FEATURES: A 36-year-old nulliparous woman presented to a free clinic for veterans and their spouses. She received a PMS diagnosis at age 18. She was previously prescribed hormonal birth control and nonsteroidal anti-inflammatory drugs, which minimally affected her condition. She stopped using conventional medicine therapies at age 27...
September 2023: Journal of Chiropractic Medicine
https://read.qxmd.com/read/37644134/comparison-of-miralax-and-magnesium-citrate-for-bowel-preparation-at-ct-colonography
#23
JOURNAL ARTICLE
Nicholas Zacharias, Meghan G Lubner, David H Kim, Perry J Pickhardt
PURPOSE: To compare MiraLAX, a hypo-osmotic lavage, and magnesium citrate (MgC), a hyper-osmotic agent for bowel preparation at CTC. METHODS: 398 total screening CTC studies were included in this retrospective, single institution study. 297 underwent preparation with a double-dose MgC regimen (mean age, 61 ± 5.5 years; 142 male/155 female) and 101 with 8.3 oz (equivalent to 238 g PEG) of MiraLAX (mean age, 60 ± 9.6 years; 45 male/56 female)...
August 29, 2023: Abdominal Radiology
https://read.qxmd.com/read/37635222/serum-and-24-hour-urinary-tests-cost-effectiveness-in-stone-formers
#24
JOURNAL ARTICLE
Abdolreza Mohammadi, Hiro Farabi, Leila Zareian Baghdadabad, Behzad Narouie, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir
OBJECTIVE: To assess the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers. METHODS: This study analyzes the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers. The sensitivity and specificity, false positive, and negative results of the tests are extracted from diagnostic kits used in the laboratories of the target community...
August 27, 2023: BMC Urology
https://read.qxmd.com/read/37601750/relative-supersaturation-values-distinguish-between-feline-urinary-and-non-urinary-foods-and-align-with-expected-urine-analytes-contributions-to-uroliths
#25
JOURNAL ARTICLE
Elizabeth M Morris, Allison P McGrath, John Brejda, Dennis E Jewell
INTRODUCTION: Uroliths are concretions formed in the urinary tract. These can be problematic in humans and companion animals such as cats. Magnesium ammonium phosphate (struvite) and calcium oxalate (CaOx) are the most common forms of uroliths. The relative supersaturation (RSS) is a relative risk index of crystal formation. Here, an updated program for calculating RSS, EQUIL-HL21, was used to detect differences in RSS values when cats were fed foods formulated for urinary and non-urinary conditions...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37591223/comparative-efficacy-and-acceptability-of-12-phosphorus-lowering-drugs-in-adults-with-hyperphosphatemia-and-chronic-kidney-disease-a-systematic-review-and-network-meta-analysis
#26
Houli Luo, Jian Feng, Gang Xue, Yanbiao Zhang, Yunming Li, Xi Huang, Xin Chen, Shuang You, Hongfei Dong, Lingfan Li, Juncheng Li, Hualin Xiao, Xiang Ai, Xianhui Li, Bo Huang
BACKGROUND: Hyperphosphatemia is associated with cardiovascular morbidity and mortality in adults with chronic kidney disease (CKD). Drug therapy has an irreplaceable role in the management of hyperphosphatemia. OBJECTIVES: We aimed to compare and rank phosphorus-lowering drugs, including phosphate binder and nonphosphate binder, in hyperphosphatemia adults with CKD. METHODS: We did a systematic review and frequentist random-effect network meta-analysis...
2023: Blood Purification
https://read.qxmd.com/read/37493903/assessment-of-metabolic-risk-factors-for-nephrolithiasis-in-patients-with-autosomal-dominant-polycystic-kidney-disease-a-cross-sectional-study
#27
JOURNAL ARTICLE
Onour Chasan, Safak Mirioglu, Ayse Serra Artan, Meltem Gursu, Rumeyza Kazancioglu, Omer Celal Elcioglu
BACKGROUND: Nephrolithiasis is more common in autosomal dominant polycystic kidney disease (ADPKD) than in the normal population. We aimed to investigate the anatomical and metabolic factors that may be associated with nephrolithiasis in patients with ADPKD METHODS: In this cross-sectional study, a total of 180 participants were included. Eighty-five patients with ADPKD [42 patients with nephrolithiasis (PKD N +) and 43 without nephrolithiasis (PKD N -)] were recruited. Forty-seven nephrolithiasis patients without ADPKD (N) and 48 healthy controls (HC) were selected as control groups...
July 26, 2023: Clinical and Experimental Nephrology
https://read.qxmd.com/read/37479949/effect-of-a-high-citrate-beverage-on-urine-chemistry-in-patients-with-calcium-kidney-stones
#28
JOURNAL ARTICLE
David S Goldfarb, Frank Modersitzki, John R Asplin, Lama Nazzal
A well-accepted strategy to prevent kidney stones is to increase urine volume by increasing oral intake of fluids, especially water, to lower supersaturation of the relevant, relatively insoluble salts, and thereby lower the risk of precipitation. Randomized controlled trials have shown that this strategy works. It is inexpensive, safe, and intuitively attractive to patients. However, although any beverage can increase urine volume, and citrus juices can increase urine citrate content and pH, no beverage other than water has been clearly shown by randomized controlled trial to prevent kidney stones...
July 21, 2023: Urolithiasis
https://read.qxmd.com/read/37469621/influence-of-clay-mineral-weathering-on-green-rust-formation-at-iron-reducing-conditions
#29
JOURNAL ARTICLE
Aaron R Betts, Matthew G Siebecker, Evert J Elzinga, Todd P Luxton, Kirk G Scheckel, Donald L Sparks
Green rusts (GR) are important drivers for trace metal and nutrient cycling in suboxic environments. We investigated whether green rusts would incorporate aluminum (Al) or other elements from naturally-formed clay minerals containing easily-weatherable clay minerals (e.g. mica, interlayered clays). We isolated the clay minerals from a Matapeake silt loam soil by removal of silt and sand, organic matter, and reducible oxides to study mechanisms of interaction between Fe(II) and soil-sourced clay minerals. We conducted batch Fe(II) sorption experiments at multiple near-neutral pHs (6...
June 1, 2023: Geochimica et Cosmochimica Acta
https://read.qxmd.com/read/37375733/compounded-effervescent-magnesium-for-familial-hypomagnesemia-a-case-report
#30
Giada Bennati, Mario Cirino, Giulia Benericetti, Natalia Maximova, Monica Zanier, Federico Pigato, Anna Parzianello, Alessandra Maestro, Egidio Barbi, Davide Zanon
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disorder affecting <1/1,000,000 people. It is caused by mutations in the CLDN16 (FHHNC Type 1) or CLDN19 (FHHNC Type 2) genes, which are located on Chromosomes 3q27 and 1p34.2, respectively. There are no drug therapies for this condition. Although magnesium salts represent an important class of compounds and exhibit various therapeutic actions as a supplement for magnesium deficiency in FHHNC, various formulations on the market have different bioavailability...
May 24, 2023: Pharmaceuticals
https://read.qxmd.com/read/37327280/urolithiasis-in-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis-of-13-339-065-individuals
#31
JOURNAL ARTICLE
Aldukhayel Abdulrhman, Adil Alsweed, May Rashed Alotaibi, Abdullah Yousef Aldakhil, Shahad Fahad Alahmadi, Saud Musallum Albishri, Nurah Ibrahem Alhmed
BACKGROUND: This study aimed to summarize the current literature regarding the prevalence of renal stones in patients with inflammatory bowel disease (IBD). Moreover, we aimed to evaluate the risk factors of urolithiasis in patients with IBD and the difference between patients with IBD and healthy controls in terms of urinary profile. METHODS: On February 23, 2022, a computerized search was conducted on PubMed, OVID via MEDLINE, Web of Science, and Scopus using relevant keywords...
June 16, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37326071/effectiveness-of-the-magnesium-application-in-obstetrical-practice
#32
JOURNAL ARTICLE
Vladyslav A Smiianov, Leonid B Markin, Tetiana V Fartushok, Svitlana R Slavitych
OBJECTIVE: The aim: Conducting an evaluation of the effectiveness and safety of the use of magnesium in pregnant women. PATIENTS AND METHODS: Materials and methods: A comprehensive examination of 60 pregnant women was conducted, of which 30 were taking a magnesium preparation in a daily dose of 2473.72 mg of magnesium citrate and 40 mg of pyridoxine hydrochloride (the main group) and 30 pregnant women who were not taking a magnesium preparation (сomparison group)...
2023: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/37253348/risk-factors-for-common-kidney-stones-are-correlated-with-kidney-function-independent-of-stone-composition
#33
JOURNAL ARTICLE
Kathryn E Simmons, Hari R Nair, Manali Phadke, Piruz Motamedinia, Dinesh Singh, Tinika A Montgomery, Neera K Dahl
INTRODUCTION: Kidney stone type varies with age, sex, season, and medical conditions. Lower estimate glomerular filtration rate (eGFR) leads to changes in urine chemistry, and risk factors for kidney stones are thought to vary by stone type. We explore the association between eGFR, urine risk factors, and common stone compositions. METHODS: This was a retrospective cohort study of 811 kidney stone patients seen at Yale Medicine between 1994 and 2021 with serum chemistries and 24-h urine chemistries matched within 1 year of baseline stone analysis...
2023: American Journal of Nephrology
https://read.qxmd.com/read/37222937/a-simplified-protocol-of-regional-citrate-anticoagulation-with-phosphate-containing-solutions-in-infants-and-children-treated-with-continuous-kidney-replacement-therapy
#34
JOURNAL ARTICLE
Andrea Cappoli, Raffaella Labbadia, Luca Antonucci, Gabriella Bottari, Emanuele Rossetti, Isabella Guzzo
BACKGROUND: Regional citrate anticoagulation (RCA) is the preferred modality of anticoagulation used in continuous kidney replacement therapy (CKRT) in adults and less extensively in children. Potential metabolic complications limit widespread use in infants, neonates, and in children with liver failure. METHODS: We report our experience with a simplified protocol in 50 critically ill children, infants, and neonates, some of them with liver failure, with commercially available solutions containing phosphorous and higher concentration of potassium and magnesium...
November 2023: Pediatric Nephrology
https://read.qxmd.com/read/37216071/the-impact-of-regional-citrate-anticoagulation-on-magnesium-replacement-during-crrt
#35
Jack DePriest, Cortney Dodson, Benjamin Phelps
A patient admitted to the ICU with shock and acute kidney injury required continuous renal replacement therapy (CRRT). CRRT was initiated using regional citrate anticoagulation (RCA) with an initial magnesium (Mg) level of 1.7 mg/dL. Over 12 days the patient received 68 g of Mg sulfate. After 58 g the patient's Mg level was 1.4 mg/dL. On day 13, CRRT was changed to a heparin circuit from concerns of citrate toxicity. Over the next 7 days the patient required no Mg replacement with a mean Mg level of 2...
June 2023: Hospital Pharmacy
https://read.qxmd.com/read/37190902/alginate-xanthan-gum-hydrogels-as-forensic-blood-substitutes-for-bloodstain-formation-and-analysis
#36
JOURNAL ARTICLE
Amanda Orr, Paul Wilson, Theresa Stotesbury
Understanding the behaviour of human blood outside of the body has important implications in forensic research, especially related to bloodstain pattern analysis (BPA). The design of forensic blood substitutes (FBSs) can provide many advantages, including the incorporation of multiple physiological components for use as safe and reliable materials for forensic applications. In this work, we present the design of synthetic alginate and xanthan gum-based hydrogels that contain electrosprayed microparticles (MPs) with and without crosslinked DNA...
May 16, 2023: Soft Matter
https://read.qxmd.com/read/37190897/efficacy-of-different-bowel-preparation-regimen-volumes-for-colorectal-cancer-screening-and-compliance-with-european-society-of-gastrointestinal-endoscopy-performance-measures
#37
MULTICENTER STUDY
Felix Theunissen, Marten Alexander Lantinga, Pieter C J Ter Borg, Rob J T Ouwendijk, Peter D Siersema, Marco J Bruno
BACKGROUND: Various volumes of bowel preparation are used in clinical practice. There is conflicting data on the effectiveness of individual regimens. This study aims to evaluate the efficacy and compliance of currently used bowel preparations with the European Society of Gastrointestinal Endoscopy (ESGE) performance measures using data of the Dutch nationwide colorectal cancer screening (CRC) program. METHODS: In a prospective, multicenter endoscopy database, we identified all CRC screening colonoscopies performed in 15 Dutch endoscopy centers from 2016 to 2020...
June 2023: United European Gastroenterology Journal
https://read.qxmd.com/read/37035509/kidney-stone-matrix-proteins-role-in-stone-formation
#38
REVIEW
Armando Luis Negri, Francisco Rodolfo Spivacow
Stone formation is induced by an increased level of urine crystallization promoters and reduced levels of its inhibitors. Crystallization inhibitors include citrate, magnesium, zinc, and organic compounds such as glycosaminoglycans. In the urine, there are various proteins, such as uromodulin (Tamm-Horsfall protein), calgranulin, osteopontin, bikunin, and nephrocalcin, that are present in the stone matrix. The presence of several carboxyl groups in these macromolecules reduces calcium oxalate monohydrate crystal adhesion to the urinary epithelium and could potentially protect against lithiasis...
March 25, 2023: World Journal of Nephrology
https://read.qxmd.com/read/37034970/quality-of-bowel-preparation-in-patients-with-inflammatory-bowel-disease-undergoing-colonoscopy-what-factors-to-consider
#39
REVIEW
Antonietta Gerarda Gravina, Raffaele Pellegrino, Mario Romeo, Giovanna Palladino, Marina Cipullo, Giorgia Iadanza, Simone Olivieri, Giuseppe Zagaria, Nicola De Gennaro, Antonio Santonastaso, Marco Romano, Alessandro Federico
An adequate bowel preparation in patients with inflammatory bowel disease (IBD) is a prerequisite for successful colonoscopy for screening, diagnosis, and surveillance. Several bowel preparation formulations are available, both high- and low-volume based on polyethylene glycol. Generally, low-volume formulations are also based on several compounds such as magnesium citrate preparations with sodium picosulphate, oral sulphate solution, and oral sodium phosphate-based solutions. Targeted studies on the quality of bowel preparation prior to colonoscopy in the IBD population are still required, with current evidence from existing studies being inconclusive...
March 16, 2023: World Journal of Gastrointestinal Endoscopy
https://read.qxmd.com/read/36974432/optimization-of-micro-quechers-extraction-coupled-with-gas-chromatography-mass-spectrometry-for-the-fast-determination-of-phthalic-acid-esters-in-mussel-samples
#40
JOURNAL ARTICLE
N Carro, R Fernández, S Sóñora, J Cobas, I García, M Ignacio, A Mouteira
In this study, a new miniaturized version of the analytical method based on the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) technique using Florisil in the cleanup step for extracting six phthalic acid esters (PAEs) in mussel samples was developed by using a design of experiments. For this purpose, 1.5 mL of ultrapure water and later, 1.5 mL of acetonitrile were added to 0.1 g of the lyophilized sample, followed by 0.3 g of a commercial extraction salt packet (magnesium sulfate, sodium chloride, sodium citrate dihydrate, and sodium hydrogencitrate sesquihydrate)...
March 28, 2023: Analytical Methods: Advancing Methods and Applications
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