Haley K Perlow, Ansel P Nalin, Alex R Ritter, Mark Addington, Aubrie Ward, Michal Liu, Collin Nappi, Dukagjin M Blakaj, Sasha J Beyer, Evan M Thomas, John C Grecula, Raju R Raval, Rupesh Kotecha, Daniel Boulter, Erica L Dawson, Wesley Zoller, Joshua D Palmer
PURPOSE: Recent advances to preserve neurocognitive function in patients treated for brain metastases include stereotactic radiosurgery, hippocampal avoidance whole brain radiation therapy (WBRT), and memantine administration. The hippocampus, corpus callosum, fornix, and amygdala are key neurocognitive substructures with a low propensity for brain metastases. Herein, we report our preliminary experience using a "memory-avoidance" WBRT (MA-WBRT) approach that spares these substructures for patients with >15 brain metastases...
February 2024: Advances in Radiation Oncology