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https://www.readbyqxmd.com/read/28944319/the-ethics-of-fertility-preservation-for-pediatric-patients-with-differences-disorders-of-sex-development
#1
Lisa Campo-Engelstein, Diane Chen, Arlene B Baratz, Emilie K Johnson, Courtney Finlayson
Differences (disorders) of sex development are diverse conditions with variations in chromosomal, gonadal, and/or genital development. Fertility potential in this population is variable. Recent investigations into fertility potential in those previously thought to be infertile suggest that the majority may have fertility potential through experimental protocols. Fertility preservation may be more successful if pursued in childhood. As fertility research and techniques advance, it is important to carefully consider pediatric ethical issues specific to this population, including gonadectomy, consent/assent, experimental treatment and false hope, cost and insurance coverage, genetic transmission to offspring, and gender dysphoria...
June 1, 2017: J Endocr Soc
https://www.readbyqxmd.com/read/28943405/detection-and-characterization-of-a-novel-rhabdovirus-in-aedes-cantans-mosquitoes-and-evidence-for-a-mosquito-associated-new-genus-in-the-family-rhabdoviridae
#2
Nariman Shahhosseini, Renke Lühken, Hanna Jöst, Stephanie Jansen, Jessica Börstler, Toni Rieger, Andreas Krüger, Anges Yadouleton, Renata de Mendonça Campos, Claudio Cesar Cirne-Santos, Davis Fernandes Ferreira, Rolf Garms, Norbert Becker, Egbert Tannich, Daniel Cadar, Jonas Schmidt-Chanasit
Thanks to recent advances in random amplification technologies, metagenomic surveillance expanded the number of novel, often unclassified viruses within the family Rhabdoviridae. Using a vector-enabled metagenomic (VEM) tool, we identified a novel rhabdovirus in Aedes cantans mosquitoes collected from Germany provisionally named Ohlsdorf virus (OHSDV). The OHSDV genome encodes the canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORF in the P gene. Sequence analysis indicated that OHSDV exhibits a similar genome organization and characteristics compared to other mosquito-associated rhabdoviruses (Riverside virus, Tongilchon virus and North Creek virus)...
September 21, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28943275/mifepristone-enhances-insulin-stimulated-akt-phosphorylation-and-glucose-uptake-in-skeletal-muscle-cells
#3
Izela Bernal-Sore, Mario Navarro-Marquez, César Osorio-Fuentealba, Francisco Díaz-Castro, Andrea Del Campo, Camila Donoso-Barraza, Omar Porras, Sergio Lavandero, Rodrigo Troncoso
Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic treatment-induced obesity. However, the mechanisms through which Mifepristone produces its beneficial effects are not completely elucidated. PURPOSE: To determine the effects of mifepristone on insulin-stimulated glucose uptake on a model of L6 rat-derived skeletal muscle cells...
September 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28943259/-spanish-collaborative-study-description-of-usual-clinical-practice-in-infant-obesity
#4
Alfonso Lechuga Sancho, Enrique Palomo Atance, María José Rivero Martin, Mercedes Gil-Campos, Rosaura Leis Trabazo, María Pilar Bahíllo Curieses, Gloria Bueno Lozano
INTRODUCTION: Childhood obesity is a high prevalence health problem. Although there are clinical guidelines for its management, there is variability in its clinical approach. The aim of this study is to describe the usual clinical practice in Paediatric Endocrinology Units in Spain and to evaluate if it resembles the recommended guidelines. MATERIAL AND METHODS: An observational, cross-sectional and descriptive study was carried out by means of a questionnaire sent to paediatric endocrinologists of the Spanish Society of Paediatric Endocrinology...
September 21, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28942758/identification-and-heterologous-expression-of-the-kocurin-biosynthetic-gene-cluster
#5
Luis Linares-Otoya, Virginia Linares-Otoya, Lizbeth Armas-Mantilla, Cyntia Blanco-Olano, Max Crüsemann, Mayar L Ganoza-Yupanqui, Julio Campos-Florian, Gabriele M König, Till F Schäberle
The antibiotically bioactive thiopeptide compound kocurin was identified in extracts from a newly isolated Kocuria rosea strain. The axenic strain was retrieved from a soil sample of the intertidal area at the Paracas National Park, Peru. The genetic basis of this promising natural product with activity against methicillin-resistant Staphylococcus aureus (MRSA) strains was revealed by comparative genome analysis of this new isolate and other reported thiopeptide producer strains. The functionality of the predicted gene locus was experimentally proven by heterologous expression in Streptomyces coelicolor M1146...
September 25, 2017: Microbiology
https://www.readbyqxmd.com/read/28941993/dna-methylation-polymerase-chain-reaction-pcr-array-of-apoptosis-related-genes-in-pleomorphic-adenomas-of-the-salivary-glands
#6
Núbia Braga Pereira, Ana Carolina de Melo do Carmo, Kelma Campos, Sara Ferreira Dos Santos Costa, Marina Gonçalves Diniz, Ricardo Santiago Gomez, Carolina Cavalieri Gomes
OBJECTIVE: The aim of this study was to evaluate the DNA methylation profile in 22 apoptosis-related genes in pleomorphic adenomas (PAs) of the salivary glands, in comparison with normal salivary glands (NSGs), and to address the differences in methylation patterns between smaller and larger tumors. Additionally, we investigated if the hypermethylation of differentially methylated genes between NSGs and PAs impacted the messenger RNA (mRNA) transcription. DESIGN: Twenty-three fresh PA samples and 12 NSG samples were included...
August 31, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28941141/evaluation-of-cutaneous-rejuvenation-associated-with-the-use-of-ortho-silicic-acid-stabilized-by-hydrolyzed-marine-collagen
#7
Célia Luiza Petersen Vitello Kalil, Valéria Campos, Stela Cignachi, Juliana Favaro Izidoro, Clarissa Prieto Herman Reinehr, Christine Chaves
BACKGROUND: Organic silicon plays an important role in dermal structure by promoting neocollagenesis. Thus, the supplementation of silicon in a highly bioavailable form can be used for skin rejuvenation. AIMS: This study aimed to evaluate skin changes associated with the use of ortho-silicic acid stabilized by hydrolyzed collagen. PATIENTS/METHODS: Patients were randomized to receive 600 mg of ortho-silicic acid stabilized by hydrolyzed collagen (group 1, n = 11) or placebo (group 2, n = 11) to be taken 15 minutes before breakfast for 90 days...
September 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28940979/electronic-delocalization-in-two-and-three-dimensions-differential-aggregation-in-indium-metalloid-clusters
#8
Simon Aldridge, Andrey Protchenko, Juan Urbano, Joseph Abdalla, Jesus Campos, Dragoslav Vidovic, Andrew Schwarz, Matthew Blake, Philip Mountford, Cameron Jones
Reduction of indium boryl precursors to give two- and three-dimensional M-M bonded networks is influenced by the choice of supporting ligand. While the unprecedented nanoscale cluster [In68(boryl)12]- (with an In12@In44@In12(boryl)12 concentric structure), can be isolated from the potassium reduction of a bis(boryl)indium(III) chloride precursor, analogous reduction of the corresponding (benzamidinate)InIIIBr(boryl) system gives a near-planar (and weakly aromatic) tetranuclear [In4(boryl)4]2- system.
September 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28939247/-spanish-validation-of-game-addiction-scale-for-adolescents-gasa
#9
Daniel Lloret Irles, Ramon Morell Gomis, Juan Carlos Marzo Campos, Sonia Tirado González
OBJECTIVE: The aim of this study is to adapt and validate the Game Addiction Scale for Adolescents (GASA) to the Spanish youth population. DESIGN: Cultural adaptation and validation study. SETTING: Secondary Education centres. PARTICIPANTS: Two independent studies were conducted on a group of 466 young people with a mean age of 15.27 years (13-18, SD: 1.83) and 48.7% ♀ and on another group of 566, with a mean age of 21...
September 19, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28939015/the-role-of-self-efficacy-on-the-prognosis-of-chronic-musculoskeletal-pain-a-systematic-review
#10
REVIEW
Javier Martinez-Calderon, Carmen Zamora-Campos, Santiago Navarro-Ledesma, Alejandro Luque-Suarez
Evidence suggests that self-efficacy can play an essential role as a protective factor as well as a mediator in the relationship between pain-disability in people suffering from chronic musculoskeletal pain. This study systematically reviewed and critically appraised the role of self-efficacy on the prognosis of chronic musculoskeletal pain. Study selection was based on longitudinal studies testing the prognostic value of self-efficacy in chronic musculoskeletal pain. The Newcastle-Ottawa Scale, the Cochrane Collaboration's tool, and the Methodological Index for Non-Randomized Studies (MINORS) checklist were used to evaluate the risk of bias of included studies...
September 19, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28937646/effects-of-liposomes-contained-in-thermosensitive-hydrogels-as-biomaterials-useful-in-neural-tissue-engineering
#11
Yusser Olguín, Cristian Campos, Javiera Catalán, Luís Velásquez, Fernando Osorio, Iván Montenegro, Alejandro Madrid, Cristian Acevedo
Advances in the generation of suitable thermosensitive hydrogels for the delivery of cells in neural tissue engineering demonstrate a delicate relationship between physical properties and capabilities to promote cell proliferation and differentiation. To improve the properties of these materials, it is possible to add liposomes for the controlled release of bioactive elements, which in turn can affect the physical and biological properties of the hydrogels. In the present investigation, different hydrogels based on Pluronic F127 have been formulated with the incorporation of chitosan and two types of liposomes of two different sizes...
September 22, 2017: Materials
https://www.readbyqxmd.com/read/28937271/assesment-of-radiation-induced-secondary-cancer-risk-in-the-brazilian-population-from-left-sided-breast-3d-crt-using-mcnpx
#12
Bruno Melo Mendes, Bruno Machado Trindade, Telma Cristina Ferreira Fonseca, Tarcisio Passos Ribeiro de Campos
OBJECTIVE: The aim of this work was to simulate a 6MV conventional breast 3D conformational radiotherapy (3D-CRT) with physical wedges (50Gy/25#) in the left breast, calculate the mean absorbed dose in the body organs using robust models and computational tools and estimate the secondary cancer-incidence risk to the Brazilian population. METHODS: The VW female phantom was used in the simulations. PTV was defined in the left breast. The 6MV parallel-opposed fields breast-RT protocol was simulated with MCNPx code...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937173/adsorption-of-molecular-hydrogen-on-coronene-with-a-new-potential-energy-surface
#13
Massimiliano Bartolomei, Ricardo Pérez de Tudela, Kilian Arteaga, Tomás González-Lezana, Marta I Hernández, José Campos-Martínez, Pablo Villarreal, Javier Hernández-Rojas, José Bretón, Fernando Pirani
Benchmark interaction energies between coronene, C24H12, and molecular hydrogen, H2, have been computed by means of high level electronic structure calculations. Binding energies, equilibrium distances and strengths of the long range attraction, evaluated for the basic configurations of the H2-C24H12 complex, indicate that the system is not too affected by the relative orientations of the diatom, suggesting that its behavior can be approximated to that of a pseudoatom. The obtained energy profiles have confirmed the noncovalent nature of the bonding and serve to tune-up the parameters of a new force field based on the atom-bond approach which correctly describes the main features of the H2-coronene interaction...
September 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28937150/el-buen-cuidado-de-pacientes-que-fallecen-en-unidades-de-cuidados-intensivos-en-espa%C3%A3-a-un-estudio-basado-en-indicadores-internacionales-de-calidad-asistencial
#14
M B Girbau Campo, P Monedero, C Centeno
No abstract text is available yet for this article.
September 22, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28936735/dual-behavior-of-exosomes-in-septic-cardiomyopathy
#15
Valter Vinícius Silva Monteiro, Jordano Ferreira Reis, Rafaelli de Souza Gomes, Kely Campos Navegantes, Marta Chagas Monteiro
Sepsis is one of the main causes of ICU hospitalization worldwide, with a high mortality rate, and is associated with a large number of comorbidities. One of the main comorbidities associated with sepsis is septic cardiomyopathy. This process occurs mainly due to mechanisms of damage in the cardiovascular system that will lead to changes in cardiovascular physiology, such as decreased Ca(2+) response, mitochondrial dysfunction and decreased β-adrenergic receptor response. Within this process the exosomes play an important role in the pathophysiology of this disease, in which the exosomal content is related to mechanisms that will trigger its development...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28935954/process-signatures-in-glatiramer-acetate-synthesis-structural-and-functional-relationships
#16
Víctor R Campos-García, Daniel Herrera-Fernández, Carlos E Espinosa-de la Garza, German González, Luis Vallejo-Castillo, Sandra Avila, Leslie Muñoz-García, Emilio Medina-Rivero, Néstor O Pérez, Isabel Gracia-Mora, Sonia Mayra Pérez-Tapia, Rodolfo Salazar-Ceballos, Lenin Pavón, Luis F Flores-Ortiz
Glatiramer Acetate (GA) is an immunomodulatory medicine approved for the treatment of multiple sclerosis, whose mechanisms of action are yet to be fully elucidated. GA is comprised of a complex mixture of polypeptides with different amino acid sequences and structures. The lack of sensible information about physicochemical characteristics of GA has contributed to its comprehensiveness complexity. Consequently, an unambiguous determination of distinctive attributes that define GA is of highest relevance towards dissecting its identity...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935805/teaching-personal-initiative-beats-traditional-training-in-boosting-small-business-in-west-africa
#17
Francisco Campos, Michael Frese, Markus Goldstein, Leonardo Iacovone, Hillary C Johnson, David McKenzie, Mona Mensmann
Standard business training programs aim to boost the incomes of the millions of self-employed business owners in developing countries by teaching basic financial and marketing practices, yet the impacts of such programs are mixed. We tested whether a psychology-based personal initiative training approach, which teaches a proactive mindset and focuses on entrepreneurial behaviors, could have more success. A randomized controlled trial in Togo assigned microenterprise owners to a control group (n = 500), a leading business training program (n = 500), or a personal initiative training program (n = 500)...
September 22, 2017: Science
https://www.readbyqxmd.com/read/28935290/objectives-and-methodology-of-biobadaser-phase-iii
#18
Carlos Sanchez-Piedra, M Victoria Hernández Miguel, Javier Manero, Rosa Roselló, Jesús Tomás Sánchez-Costa, Carlos Rodríguez-Lozano, Cristina Campos, Eduardo Cuende, Jesús Carlos Fernández-Lopez, Sagrario Bustabad, Raquel Martín Domenech, Eva Pérez-Pampín, Javier Del Pino-Montes, Ana Milena Millan-Arcineas, Federico Díaz-González, Juan Jesús Gómez-Reino
OBJECTIVE: Describe the objectives, methods and results of the first year of the new version of the Spanish registry of adverse events involving biological therapies and synthetic drugs with an identifiable target in rheumatic diseases (BIOBADASER III). METHODOLOGY: Multicenter prospective registry of patients with rheumatic inflammatory diseases being treated with biological drugs or synthetic drugs with an identifiable target in rheumatology departments in Spain...
September 18, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28935077/a-prospective-evaluation-of-a-pre-specified-absorb-bvs-implantation-strategy-in-st-segment-elevation-myocardial-infarction-the-bvs-stemi-strategy-it-study
#19
Alfonso Ielasi, Gianluca Campo, Claudio Rapetto, Attilio Varricchio, Bernardo Cortese, Salvatore Brugaletta, Salvatore Geraci, Paolo Vicinelli, Fortunato Scotto di Uccio, Gioel Gabrio Secco, Arnaldo Poli, Elisa Nicolini, Kohki Ishida, Azeem Latib, Maurizio Tespili
OBJECTIVES: The aim of this study was to assess the feasibility and clinical results following a pre-specified bioresorbable scaffold (Absorb BVS) implantation strategy in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Concerns were raised about the safety of Absorb because a non-negligible rate of thrombosis was reported within 30 days and at midterm follow-up after primary percutaneous coronary intervention. METHODS: This was a prospective, multicenter study of patients with STEMI (<75 years of age with symptom onset <12 h) undergoing primary percutaneous coronary intervention with Absorb following a dedicated implantation protocol...
September 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28934587/aging-in-the-cardiovascular-system-lessons-from-hutchinson-gilford-progeria-syndrome
#20
Magda R Hamczyk, Lara Del Campo, Vicente Andrés
Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden. Atherosclerosis and heart failure contribute significantly to age-associated CVD-related morbimortality. CVD and aging are both accelerated in patients suffering from Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder caused by the prelamin A mutant progerin...
September 20, 2017: Annual Review of Physiology
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