Yakun Liu, Jie Xiao, Ben Zhang, Thomas R Shelite, Zhengchen Su, Qing Chang, Barbara Judy, Xiang Li, Aleksandra Drelich, Jiani Bei, Yixuan Zhou, Junying Zheng, Yang Jin, Shannan L Rossi, Shao-Jun Tang, Maki Wakamiya, Tais Saito, Thomas Ksiazek, Bhupendra Kaphalia, Bin Gong
Talin and vinculin, both actin-cytoskeleton-related proteins, have been documented to participate in establishing bacterial infections, respectively, as the adapter protein to mediate cytoskeleton-driven dynamics of the plasma membrane. However, little is known regarding the potential role of the talin-vinculin complex during spotted fever group rickettsial and Ebola virus infections, two dreadful infectious diseases in humans. Many functional properties of proteins are determined by their participation in protein-protein complexes, in a temporal and/or spatial manner...
April 1, 2020: Laboratory Investigation; a Journal of Technical Methods and Pathology