keyword
https://read.qxmd.com/read/38481171/the-efficacy-of-extracellular-vesicles-for-acute-lung-injury-in-preclinical-animal-models-a-meta-analysis
#21
JOURNAL ARTICLE
Xuefeng Zhang, Zongyong Cheng, Menghao Zeng, Zhihui He
BACKGROUND: With the increasing research on extracellular vesicles (EVs), EVs have received widespread attention as biodiagnostic markers and therapeutic agents for a variety of diseases. Stem cell-derived EVs have also been recognized as a new viable therapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To assess their efficacy, we conducted a meta-analysis of existing preclinical experimental animal models of EVs for ALI treatment. METHODS: The database was systematically interrogated for pertinent data encompassing the period from January 2010 to April 2022 concerning interventions involving extracellular vesicles (EVs) in animal models of acute lung injury (ALI)...
March 13, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38480836/universal-sting-mimic-boosts-antitumour-immunity-via-preferential-activation-of-tumour-control-signalling-pathways
#22
JOURNAL ARTICLE
Ying Wang, Sirui Li, Mengying Hu, Yuchen Yang, Ellie McCabe, Lillian Zhang, Andrew M Withrow, Jenny P-Y Ting, Rihe Liu
The efficacy of STING (stimulator of interferon genes) agonists is due to various factors, primarily inefficient intracellular delivery, low/lack of endogenous STING expression in many tumours, and a complex balance between tumour control and progression. Here we report a universal STING mimic (uniSTING) based on a polymeric architecture. UniSTING activates STING signalling in a range of mouse and human cell types, independent of endogenous STING expression, and selectively stimulates tumour control IRF3/IFN-I pathways, but not tumour progression NF-κB pathways...
March 13, 2024: Nature Nanotechnology
https://read.qxmd.com/read/38478174/mesenchymal-stem-cells-derived-exosomes-carrying-microrna-30b-confer-protection-against-pulmonary-fibrosis-by-downregulating-runx1-via-spred2
#23
JOURNAL ARTICLE
Liang Zhu, Yun Xu, Jianqing Wang, Yi Zhang, Jiawang Zhou, Huaxiang Wu
Idiopathic pulmonary fibrosis (IPF) is a chronic pulmonary fibrosis disease that is fatal. Mesenchymal stem cells (MSCs)-secreted exosomes (exos) have been linked to improving PF. Moreover, exosomal microRNAs (miRs) can control the growth of numerous diseases, including lung disorders. Our bioinformatics analysis showed that miR-30b was downregulated in tissue samples from surgical remnants of biopsies or lungs explanted from patients with IPF who underwent pulmonary transplantation. This suggests that miR-30b plays an important role in both the pathogenesis and treatment of IPF...
March 13, 2024: Molecular Genetics and Genomics: MGG
https://read.qxmd.com/read/38477953/mesenchymal-stem-cell-derived-exosome-an-interesting-nanocarrier-to-improve-allergen-specific-intranasal-immunotherapy
#24
JOURNAL ARTICLE
Sajad Dehnavi, Maryam Dadmanesh, Negin Hosseini Rouzbahani, Mahmood Karimi, Ali Asadirad, Mohammad Gholami, Khodayar Ghorban
Increasing the efficacy of allergen-specific intranasal immunotherapy (INIT) has recently been the main goal of several studies to establish this route as a safe delivery method through mucosal pathways. In this case, the present study evaluated the potential of INIT using ovalbumin (OVA)-loaded mesenchymal stromal/stem cell (MSC)-derived exosomes (Exo-OVA) in an allergic asthma mouse model. Together with control groups, sensitized Balb/c mice underwent intranasal immunotherapy with Exo-OVA (10 μg OVA per dose) for three consecutive weeks...
December 28, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38474091/uba6-inhibition-accelerates-lysosomal-trpml1-depletion-and-exosomal-secretion-in-lung-cancer-cells
#25
JOURNAL ARTICLE
Dongun Lee, Peter Chang-Whan Lee, Jeong Hee Hong
Ubiquitin-like modifier-activating enzyme 6 (UBA6) is a member of the E1 enzyme family, which initiates the ubiquitin-proteasome system (UPS). The UPS plays critical roles not only in protein degradation but also in various cellular functions, including neuronal signaling, myocardial remodeling, immune cell differentiation, and cancer development. However, the specific role of UBA6 in cellular functions is not fully elucidated in comparison with the roles of the UPS. It has been known that the E1 enzyme is associated with the motility of cancer cells...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473889/pulmonary-biodistribution-of-platelet-derived-regenerative-exosomes-in-a-porcine-model
#26
JOURNAL ARTICLE
Skylar A Rizzo, Monique S Bagwell, Paige Schiebel, Tyler J Rolland, Ryan C Mahlberg, Tyra A Witt, Mary E Nagel, Paul G Stalboerger, Atta Behfar
The purpose of this study was to evaluate the biodistribution of a platelet-derived exosome product (PEP), previously shown to promote regeneration in the setting of wound healing, in a porcine model delivered through various approaches. Exosomes were labeled with DiR far-red lipophilic dye to track and quantify exosomes in tissue, following delivery via intravenous, pulmonary artery balloon catheter, or nebulization in sus scrofa domestic pigs. Following euthanasia, far-red dye was detected by Xenogen IVUS imaging, while exosomal protein CD63 was detected by Western blot and immunohistochemistry...
February 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472181/inhalation-of-ace2-expressing-lung-exosomes-provides-prophylactic-protection-against-sars-cov-2
#27
JOURNAL ARTICLE
Zhenzhen Wang, Shiqi Hu, Kristen D Popowski, Shuo Liu, Dashuai Zhu, Xuan Mei, Junlang Li, Yilan Hu, Phuong-Uyen C Dinh, Xiaojie Wang, Ke Cheng
Continued emergence of SARS-CoV-2 variants of concern that are capable of escaping vaccine-induced immunity highlights the urgency of developing new COVID-19 therapeutics. An essential mechanism for SARS-CoV-2 infection begins with the viral spike protein binding to the human ACE2. Consequently, inhibiting this interaction becomes a highly promising therapeutic strategy against COVID-19. Herein, we demonstrate that ACE2-expressing human lung spheroid cells (LSC)-derived exosomes (LSC-Exo) could function as a prophylactic agent to bind and neutralize SARS-CoV-2, protecting the host against SARS-CoV-2 infection...
March 12, 2024: Nature Communications
https://read.qxmd.com/read/38470324/thermophoretic-aggregation-imaging-of-tumor-derived-exosomes-by-crispr-cas13a-based-nanoprobes
#28
JOURNAL ARTICLE
Ping Zhou, Yingbo Pan, Bo Liu, Wei Pan, Na Li, Bo Tang
The inherent heterogeneity of tumor-derived exosomes holds great promise for enhancing the precision of cancer diagnostics. MicroRNAs (miRNAs) encapsulated in tumor-associated exosomes have emerged as valuable biomarkers for the early detection of cancers. Nevertheless, the flexible structure and inherent instability of RNA limit its application in biological diagnostics. The CRISPR-Cas13a system, distinguished by its target-responsive "collateral effect", represents a powerful tool for advancing cancer diagnostics...
March 12, 2024: Analytical Chemistry
https://read.qxmd.com/read/38449802/human-adenovirus-type-3-restores-pharmacologically-inhibited-exosomal-cargo-in-lung-carcinoma-cells
#29
JOURNAL ARTICLE
Ayodeji O Ipinmoroti, Rachana Pandit, Brennetta J Crenshaw, Brian Sims, Qiana L Matthews
Introduction: Drug repurposing is fast growing and becoming an attractive approach for identifying novel targets, such as exosomes for cancer and antiviral therapy. Exosomes are a specialized class of extracellular vesicles that serve as functional mediators in intercellular communication and signaling that are important in normal physiological functions. A continuously growing body of evidence has established a correlation between the abnormal release of exosomes with various viral disease pathologies including cancer...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38445783/exosome-inhibiting-polymeric-sonosensitizer-for-tumor-specific-sonodynamic-immunotherapy
#30
JOURNAL ARTICLE
Jiayan Wu, Jingsheng Huang, Jie Yu, Mengke Xu, Jing Liu, Kanyi Pu
Combination cancer immunotherapy based on electromagnetic energy and immunotherapy has shown potent anti-cancer efficacy. However, as a factor that mediates tumor metastasis and immune suppression, the impact of tumor exosomes on therapy under electromagnetic energy stimulation remains unclear. Herein, our findings indicate that sonodynamic therapy (SDT) increases serum exosome levels by inducing apoptotic exosomes and loosening the tumor extracellular matrix, promoting lung metastasis. To address this problem, we synthesize an exosome-inhibiting polymeric sonosensitizer (EIPS) selectively inhibiting tumor exosome generation in response to the tumor biomarker...
March 6, 2024: Advanced Materials
https://read.qxmd.com/read/38445696/recent-trends-and-applications-of-nanostructure-based-drug-delivery-in-alleviating-chronic-obstructive-pulmonary-disease-copd
#31
JOURNAL ARTICLE
Lokesh, Nisha Gulati, Annu Saini, Sachin Singh, Gaurav Gupta, Ronan MacLoughlin, Dinesh Kumar Chellappan, Kamal Dua, Harish Dureja
Chronic Obstructive Pulmonary Disease (COPD), a chronic lung disease that causes breathing difficulties and obstructs airflow from the lungs, has a significant global health burden and affects millions of people worldwide. The use of pharmaceuticals in COPD treatment is aimed to alleviate symptoms, improve lung function, prevent exacerbations, and enhance the overall quality of life for patients. Nanotechnology holds great promise to alleviate the burden of COPD. The main goal of this review is to present the full spectrum of therapeutics based on nanostructures for the treatment and management of COPD, including nanoparticles, polymeric nanoparticles, polymeric micelles, solid-lipid nanoparticles, liposomes, exosomes, nanoemulsions, nanosuspensions, and niosomes...
March 5, 2024: Current Drug Delivery
https://read.qxmd.com/read/38444129/-effects-of-human-umbilical-cord-mesenchymal-stem-cells-mscs-derived-exosomes-on-pulmonary-vascular-remodeling-in-hypoxic-pulmonary-hypertension
#32
JOURNAL ARTICLE
Hong Liu, Yu-Wei Zhang, Qing-Qing Zhang, Yu-Xiang Wang, Ri-Li Ge, Lan Ma
The present study aimed to investigate the effect of human umbilical cord mesenchymal stem cells (MSCs)-derived exosomes (MSCs-Exo) on mice with hypoxic pulmonary hypertension (HPH). MSCs were isolated and cultured from human umbilical cords under aseptic conditions, and exosomes were extracted from the supernatants and identified. Healthy SPF C57BL/6 mice were randomly divided into three groups: normoxic group, hypoxic group, and hypoxic+MSCs-Exo group. Mice in the hypoxic group and the hypoxic+MSCs-Exo group were maintained for 28 d at an equivalent altitude of 5 000 m in a hypobaric chamber to establish HPH mouse model...
February 25, 2024: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://read.qxmd.com/read/38442573/therapeutic-potential-of-adsc-ev-derived-lncrna-dleu2-a-novel-molecular-pathway-in-alleviating-sepsis-induced-lung-injury-via-the-mir-106a-5p-lxn-axis
#33
JOURNAL ARTICLE
Wei He, Chengcheng Xu, Yuying Huang, Qiuzhen Zhang, Wang Chen, Chengkuan Zhao, Yun Chen, Danling Zheng, XinyueLin, Qianhua Luo, Xiaoshan Chen, Zhihan Zhang, Xiaolong Wu, Jianxiang Huang, Chaoxian Lin, Yihui Huang, Shuyao Zhang
This study investigates the molecular mechanisms by which extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (ADSCs) promote M2 polarization of macrophages and thus reduce lung injury caused by sepsis. High-throughput sequencing was used to identify differentially expressed genes related to long non-coding RNA (lncRNA) in ADSC-derived EVs (ADSC-EVs) in sepsis lung tissue. Weighted gene co-expression network analysis (WGCNA) was employed to predict the downstream target genes of the lncRNA DLEU2...
March 4, 2024: International Immunopharmacology
https://read.qxmd.com/read/38439876/tp53-mitigates-cisplatin-resistance-in-non-small-cell-lung-cancer-by-mediating-the-effects-of-resistant-cell-derived-exosome-mir-424-5p
#34
JOURNAL ARTICLE
Yan Deng, Hao Ding, Yanhua Zhang, Xudong Feng, Qing Ye, Rui Tian, Yuchuan Xu, Qingqing He, Qiaofen Fu, Rongqing Li
BACKGROUND: Cisplatin (DDP) is the principal agent used for chemotherapy in patients with non-small cell lung cancer (NSCLC). Nevertheless, DDP resistance is an essential cause for a worse prognosis of patient. Therefore, this study proposes to discover features of miR-424-5p in DDP resistance of NSCLC. METHOD: After exogenous modulation of miR-424-5p expression, A549 cell activity was measured using CCK-8 and flow cytometry. A549/DDP and A549/DDP-associated subcutaneous tumor model were constructed to investigate the effect of miR-424-5p on DDP resistance in NSCLC in vivo ...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38431997/machine-learning-based-exosome-profiling-of-multi-receptor-sers-sensors-for-differentiating-adenocarcinoma-in-situ-from-early-stage-invasive-adenocarcinoma
#35
JOURNAL ARTICLE
Dechan Lu, Bohan Zhang, Zhikun Shangguan, Yudong Lu, Jingbo Chen, Zufang Huang
Exosomes, extracellular vesicles released by cells, hold potential as diagnostic markers for the early detection of lung cancer. Despite their clinical promise, current technologies lack rapid and effective means to discriminate between exosomes derived from adenocarcinoma in situ (AIS) and early-stage invasive adenocarcinoma (IAC). This challenge arises from the intrinsic structural heterogeneity of exosomes, necessitating the development of advanced methodologies for precise differentiation. Here, we demonstrate a novel approach for plasma exosome detection utilizing multi-receptor surface-enhanced Raman spectroscopy (SERS) technology to differentiate between AIS and early-stage IAC...
February 24, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38430034/bone-mesenchymal-stem-cell-derived-exosomal-mir-26a-3p-promotes-autophagy-to-attenuate-lps-induced-apoptosis-and-inflammation-in-pulmonary-microvascular-endothelial-cells
#36
JOURNAL ARTICLE
Qianfei Wang, Yiming Huang, Zherui Fu
Acute lung injury (ALI) is a serious lung disease. The apoptosis and inflammation of pulmonary microvascular endothelial cells (PMVECs) are the primary reasons for ALI. This study aimed to explore the treatment effect and regulatory mechanism of bone mesenchymal stem cell-derived exosomes (BMSC-expos) on ALI. PMVECs were stimulated by Lipopolysaccharide (LPS) to imitate ALI environment. Cell viability was determined by CCK-8 assay. Cell apoptosis was evaluated by TUNEL and flow cytometry. ELISA was utilized for testing the contents of TNF-α, IL-1β, IL-6, and IL-17...
February 29, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38425288/exosomal-mir-223-promotes-ards-by-targeting-insulin-like-growth-factor-1-receptor-a-cell-communication-study
#37
JOURNAL ARTICLE
Miaomiao Li, Lilei Zhuang, Tao Jiang, Li Sun
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a respiratory failure syndrome characterized by hypoxemia and changes in the respiratory system. ARDS is the most common cause of death in COVID-19 deaths was ARDS. In this study, we explored the role of miR-223 in exosomes in ARDS. METHODS: Exosomes were purified from the supernatants of macrophages. qPCR was used to detect relative mRNA levels. A luciferase reporter assay was performed to verify the miRNA target genes...
2024: Experimental Lung Research
https://read.qxmd.com/read/38416824/modulating-tumoral-exosomes-and-fibroblast-phenotype-using-nanoliposomes-augments-cancer-immunotherapy
#38
JOURNAL ARTICLE
May S Freag, Mostafa T Mohammed, Arpita Kulkarni, Hagar E Emam, Krishna P Maremanda, Ahmed O Elzoghby
Cancer cells program fibroblasts into cancer associated fibroblasts (CAFs) in a two-step manner. First, cancer cells secrete exosomes to program quiescent fibroblasts into activated CAFs. Second, cancer cells maintain the CAF phenotype via activation of signal transduction pathways. We rationalized that inhibiting this two-step process can normalize CAFs into quiescent fibroblasts and augment the efficacy of immunotherapy. We show that cancer cell-targeted nanoliposomes that inhibit sequential steps of exosome biogenesis and release from lung cancer cells block the differentiation of lung fibroblasts into CAFs...
March 2024: Science Advances
https://read.qxmd.com/read/38403456/lung-specific-exosomes-for-doxorubicin-delivery-in-lung-adenocarcinoma-therapy
#39
JOURNAL ARTICLE
Fengqiang Yu, Yanxun Chen, Weiqiang Yi, Maohao Guan, Nanlong Lin, Yi Zhuo, Jianbo Lin, Fancai Lai
Doxorubicin (DOX) could be utilized to treat lung adenocarcinoma (LUAD), while dose-limiting cardiotoxicity limits its clinical utilization. MDA-MB-231 cell-derived exosomes show lung-specific organotropism features. In this study, we aimed to explore the potential of MDA-MB-231 cell-derived exosomes in DOX specific delivery to the lung. MDA-MB-231 cell-derived exosomes were coincubated with to construct for the doxorubicin delivery system (D-EXO). Exosomes labeled with fluorescein isothiocyanate were incubated with A549 cells or 293T cells, and the engulf and the mean intensity of the fluorescence were detected with immunofluorescence and flow cytometry assay...
February 2024: Biotechnology Journal
https://read.qxmd.com/read/38403399/a-large-scale-production-of-mesenchymal-stem-cells-and-their-exosomes-for-an-efficient-treatment-against-lung-inflammation
#40
JOURNAL ARTICLE
Jinsong Zhang, Ruyi Lin, Yingyu Li, Jiawen Wang, Huiqing Ding, Panfeng Fang, Yingzhi Huang, Jing Shi, Jianqing Gao, Tianyuan Zhang
Mesenchymal stem cells (MSCs) and their produced exosomes have demonstrated inherent capabilities of inflammation-guided targeting and inflammatory modulation, inspiring their potential applications as biologic agents for inflammatory treatments. However, the clinical applications of stem cell therapies are currently restricted by several challenges, and one of them is the mass production of stem cells to satisfy the therapeutic demands in the clinical bench. Herein, a production of human amnion-derived MSCs (hMSCs) at a scale of over 1 × 109 cells per batch was reported using a three-dimensional (3D) culture technology based on microcarriers coupled with a spinner bioreactor system...
February 2024: Biotechnology Journal
keyword
keyword
37010
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.