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Exosomes and lung

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https://www.readbyqxmd.com/read/29780635/liquid-biopsy-for-lung-cancer-early-detection
#1
REVIEW
Mariacarmela Santarpia, Alessia Liguori, Alessandro D'Aveni, Niki Karachaliou, Maria Gonzalez-Cao, Maria Grazia Daffinà, Chiara Lazzari, Giuseppe Altavilla, Rafael Rosell
Molecularly targeted therapies and immune checkpoint inhibitors have markedly improved the therapeutic management of advanced lung cancer. However, it still remains the leading cause of cancer-related mortality worldwide, with disease stage at diagnosis representing the main prognostic factor. Detection of lung cancer at an earlier stage of disease, potentially susceptible of curative resection, can be critical to improve patients survival. Low-dose computed tomography (LDCT) screening of high-risk patients has been demonstrated to reduce mortality from lung cancer, but can be also associated with high false-positive rate, thus often resulting in unnecessary interventions for patients...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29760738/dental-mesenchymal-stem-stromal-cells-and-their-exosomes
#2
REVIEW
Peter Stanko, Ursula Altanerova, Jana Jakubechova, Vanda Repiska, Cestmir Altaner
Stem cells derived from human dental pulp tissue (DP-MSC) differ from the other mesenchymal stem cells prepared from bone marrow or adipose tissue due to their embryonic origin from the neural crest and are of special interest because of their neurotropic character. Furthermore, the therapeutic potential of DP-MSCs is realized through paracrine action of extracellularly released components, for which exosomes play an important role. In this review, we intend to explore the properties of these cells with an emphasis on exosomes...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29755357/-n-glycosylation-of-lipocalin-2-is-not-required-for-secretion-or-exosome-targeting
#3
Erawan Borkham-Kamphorst, Eddy Van de Leur, Steffen K Meurer, Eva M Buhl, Ralf Weiskirchen
Lipocalin 2 (LCN2) is a highly conserved secreted adipokine acting as a serum transport protein for small hydrophobic molecules such as fatty acids and steroids. In addition, LCN2 limits bacterial growth by sequestering iron-containing siderophores and further protects against intestinal inflammation and tumorigenesis associated with alterations in the microbiota. Human LCN2 contains one N -glycosylation site conserved in other species. It was postulated that this post-translational modification could facilitate protein folding, protects from proteolysis, is required for proper trafficking from the Golgi apparatus to the cell surface, and might be relevant for effective secretion...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29752284/analysis-of-the-thrombotic-and-fibrinolytic-activities-of-tumor-cell-derived-extracellular-vesicles
#4
Ludovic Durrieu, Alamelu Bharadwaj, David M Waisman
Exosomes and microvesicles (MVs) are small extracellular vesicles secreted by tumor cells and are suggested to contribute to the thrombotic events that commonly occur in patients with advanced malignancies. Paradoxically, these vesicles have been reported to also possess fibrinolytic activity. To determine whether thrombotic or fibrinolytic activity is a predominant characteristic of these extracellular vesicles, we prepared exosomes and MVs from 2 breast cancer cell lines (MDA-MB-231 and MCF7), a lung cancer cell line (A549), and a leukemia cell line (NB4) and assayed their thrombotic and fibrinolytic activities...
May 22, 2018: Blood Advances
https://www.readbyqxmd.com/read/29750307/exosomal-malat1-derived-from-oxidized-low-density-lipoprotein-treated-endothelial-cells-promotes-m2-macrophage-polarization
#5
Chaoyang Huang, Jie Han, Yutao Wu, Shan Li, Qiwen Wang, Wenjuan Lin, Jianhua Zhu
Oxidized low-density lipoprotein (oxLDL)-induced injury and apoptosis of endothelial cells are important initial events in numerous cardiovascular diseases. Following activation by oxLDL, monocytes adhere to endothelial cells, migrate into the subendothelial spaces and then undergo differentiation into macrophages, which subsequently induces the formation of atherosclerotic lesions. However, the mechanisms underlying the activation of macrophage differentiation by oxLDL-treated endothelial cells remain unclear...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29736200/adipose-derived-mesenchymal-stem-cell-derived-exosomes-alleviate-overwhelming-systemic-inflammatory-reaction-and-organ-damage-and-improve-outcome-in-rat-sepsis-syndrome
#6
Chia-Lo Chang, Pei-Hsun Sung, Kuan-Hung Chen, Pei-Lin Shao, Chih-Chao Yang, Ben-Chung Cheng, Kun-Chen Lin, Chih-Hung Chen, Han-Tan Chai, Hsueh-Wen Chang, Hon-Kan Yip, Hong-Hwa Chen
This study tested the hypothesis that healthy adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes (HMSCEXO ) and apoptotic (A) (induced by 12 h hypoxia/12 h starvation)-ADMSC-derived exosomes (AMSCEXO ) were comparably effective at alleviating sepsis syndrome [SS; induced by cecal-ligation and puncture (CLP)]-induced systemic inflammation and reduced organ damage and unfavorable outcomes in rats. SD rats were divided into sham control (SC), SS only, SS + HMSCEXO (100 µg intravenous administration 3 h after CLP), and AMSCEXO ...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29731983/exosomal-mirnas-species-in-the-blood-of-small-cell-and-non-small-cell-lung-cancer-patients
#7
Valeriy Poroyko, Tamara Mirzapoiazova, Arin Nam, Isa Mambetsariev, Bolot Mambetsariev, Xiwei Wu, Aliya Husain, Everett E Vokes, Deric L Wheeler, Ravi Salgia
Lung cancer is a devastating disease with overall bleak prognosis. Current methods to diagnose lung cancer are rather invasive and are inadequate to detect the disease at an early stage when treatment is likely to be most effective. In this study, a shotgun sequencing approach was used to study the microRNA (miRNA) cargo of serum-derived exosomes of small cell lung cancer (SCLC) (n=9) and non-small cell lung cancer (NSCLC) (n=11) patients, and healthy controls (n=10). The study has identified 17 miRNA species that are differentially expressed in cancer patients and control subjects...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29730429/lung-adenocarcinoma-cell-derived-exosomal-mir-21-facilitates-osteoclastogenesis
#8
Zhen Xu, Xingwang Liu, Huisheng Wang, Jutao Li, Lei Dai, Jun Li, Caijun Dong
Osteoclastogenesis is the rate-limiting step in tumor osteolytic metastasis. MicroRNAs play crucial roles in tumor progression and osteoclastogenesis regulation. Recent studies have demonstrated that exosomes are able to function as messengers that deliver microRNAs between cells. However, the effects of lung adenocarcinoma cell-derived exosomal miRNAs in osteoclastogenesis remain poorly understood. In this study, we found that exosomes derived from A549 cells facilitate osteoclastogenesis. As miR-21 was involved in tumorigenesis and osteoclastogenesis, we further proved the existence of miR-21 in A549 cell-derived exosomes and investigated its function...
May 3, 2018: Gene
https://www.readbyqxmd.com/read/29725020/hcc-derived-exosomes-elicit-hcc-progression-and-recurrence-by-epithelial-mesenchymal-transition-through-mapk-erk-signalling-pathway
#9
Lu Chen, Piao Guo, Yuchao He, Ziye Chen, Liwei Chen, Yi Luo, Lisha Qi, Yuanyuan Liu, Qiang Wu, Yunlong Cui, Feng Fang, Xiaofang Zhang, Tianqiang Song, Hua Guo
Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70-90% of primary liver cancers are hepatocellular carcinoma (HCC). Currently, HCC patient prognosis is unsatisfactory due to high metastasis and/or post-surgical recurrence rates. Therefore, new therapeutic methods for inhibiting metastasis and recurrence are urgently needed. Exosomes are small lipid-bilayer vesicles that are implicated in tumour development and metastasis. Rab27a, a small GTPase, regulates exosome secretion by mediating multivesicular endosome docking at the plasma membrane...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29720982/the-potential-biomarkers-and-immunological-effects-of-tumor-derived-exosomes-in-lung-cancer
#10
REVIEW
Shamila D Alipoor, Esmaeil Mortaz, Mohammad Varahram, Mehrnaz Movassaghi, Aletta D Kraneveld, Johan Garssen, Ian M Adcock
Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite considerable achievements in lung cancer diagnosis and treatment, the global control of the disease remains problematic. In this respect, greater understanding of the disease pathology is crucially needed for earlier diagnosis and more successful treatment to be achieved. Exosomes are nano-sized particles secreted from most cells, which allow cross talk between cells and their surrounding environment via transferring their cargo...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29714636/extracellular-vesicles-released-in-response-to-respiratory-exposures-implications-for-chronic-disease
#11
Birke J Benedikter, Emiel F M Wouters, Paul H M Savelkoul, Gernot G U Rohde, Frank R M Stassen
Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses. Respiratory exposures such as cigarette smoke and air pollution exert cellular stresses and are associated with an increased risk of several chronic diseases. The aim of this review was to examine the evidence that modifications in EV contribute to respiratory exposure-associated diseases. Publications were searched using PubMed and Google Scholar with the search terms (cigarette smoke OR tobacco smoke OR air pollution OR particulate matter) AND (extracellular vesicles OR exosomes OR microvesicles OR microparticles OR ectosomes)...
May 1, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29703238/integrins-as-therapeutic-targets-in-the-organ-specific-metastasis-of-human-malignant-melanoma
#12
REVIEW
Ruixia Huang, Einar K Rofstad
Integrins are a large family of adhesion molecules that mediate cell-cell and cell-extracellular matrix interactions. Among the 24 integrin isoforms, many have been found to be associated with tumor angiogenesis, tumor cell migration and proliferation, and metastasis. Integrins, especially αvβ3, αvβ5 and α5β1, participate in mediating tumor angiogenesis by interacting with the vascular endothelial growth factor and angiopoietin-Tie signaling pathways. Melanoma patients have a poor prognosis when the primary tumor has generated distant metastases, and the melanoma metastatic site is an independent predictor of the survival of these patients...
April 27, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29702191/knockdown-of-tgf-%C3%AE-1-expression-in-human-umbilical-cord-mesenchymal-stem-cells-reverts-their-exosome-mediated-emt-promoting-effect-on-lung-cancer-cells
#13
Xiaoyin Zhao, Xue Wu, Manqing Qian, Yuxian Song, Dongliang Wu, Wen Zhang
The effect of mesenchymal stem cells (MSCs) on lung cancer cells is controversial, and the underlying mechanisms remain unclear, which harms the utilization of MSCs in tumor therapy. In this study, we found that human umbilical cord MSC-conditioned medium (MSC-CM) promotes EMT, invasion, and migration, yet inhibits proliferation and promotes apoptosis of lung cancer cells. The EMT-promoting effect of MSCs was mediated by exosomes derived from MSCs (MSC-exo) and eliminated by inhibiting exosome release. Moreover, silencing TGF-β1 expression in MSCs can revert the EMT-promoting effect and enhance the anti-proliferative and pro-apoptotic effect of MSCs on lung cancer cells via MSC-exo...
April 24, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29692824/chronic-obstructive-pulmonary-disease-micrornas-and-exosomes-as-new-diagnostic-and-therapeutic-biomarkers
#14
REVIEW
Jafar Salimian, Hamed Mirzaei, Abdullah Moridikia, Asghar Beigi Harchegani, Amirhossein Sahebkar, Hossein Salehi
Chronic obstructive pulmonary disease (COPD) is known as a progressive lung disease and the fourth leading cause of death worldwide. Despite valuable efforts, there is still no accurate diagnostic and prognostic tool for COPD. Hence, it seems that finding new biomarkers could contribute to provide better therapeutic platforms for COPD patients. Among various biomarkers, microRNAs (miRNAs) have emerged as new biomarkers for the prognosis and diagnosis of patients with COPD. It has been shown that deregulation of miRNAs targeting a variety of cellular and molecular pathways such as Notch, Wnt, hypoxia-inducible factor-1α, transforming growth factor, Kras, and Smad could be involved in COPD pathogenesis...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29676587/a-potential-role-for-exosomal-tctp-export-in-vascular-remodeling-in-pulmonary-arterial-hypertension
#15
Elisabet Ferrer, Benjamin J Dunmore, Dhiya Hassan, Mark L Ormiston, Stephen Moore, John Deighton, Lu Long, Xu Dong Yang, Duncan J Stewart, Nicholas W Morrell
Pulmonary arterial hypertension (PAH) is characterized by increased proliferation and resistance to apoptosis of pulmonary vascular cells. Increased expression of translationally controlled tumor protein (TCTP), a pro-survival and anti-apoptotic mediator, has recently been demonstrated in patients with hereditary PAH (HPAH) although its role in the pathobiology of PAH remains unclear. Silencing of TCTP in blood outgrowth endothelial cells (BOECs) isolated from control subjects led to significant changes in morphology, cytoskeletal organization, increased apoptosis and decreased directionality during migration...
April 20, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29673101/identification-of-four-plasma-micrornas-as-potential-biomarkers-in-the-diagnosis-of-male-lung-squamous-cell-carcinoma-patients-in-china
#16
Xia Shan, Huo Zhang, Lan Zhang, Xin Zhou, Tongshan Wang, JinYing Zhang, Yongqian Shu, Wei Zhu, Wei Wen, Ping Liu
Dysregulated microRNAs (miRNAs) in the plasma of patients with lung squamous cell carcinoma (LSCC) might serve as biomarkers for LSCC diagnosis. The expression of miRNAs was performed using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) on the basis of Exiqon panels in the initial screening phase including three male LSCC pool samples and one normal control (NC) pool sample (per 10 samples were pooled as one pool sample). After the training (32 LSCC vs. 31 NCs), the testing (55 LSCC vs...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29665143/identification-of-potential-tumor-educated-platelets-rna-biomarkers-in-non-small-cell-lung-cancer-by-integrated-bioinformatical-analysis
#17
Linlin Xue, Li Xie, Xingguo Song, Xianrang Song
BACKGROUND: Platelets have emerged as key players in tumorigenesis and tumor progression. Tumor-educated platelet (TEP) RNA profile has the potential to diagnose non-small-cell lung cancer (NSCLC). The objective of this study was to identify potential TEP RNA biomarkers for the diagnosis of NSCLC and to explore the mechanisms in alternations of TEP RNA profile. METHODS: The RNA-seq datasets GSE68086 and GSE89843 were downloaded from Gene Expression Omnibus DataSets (GEO DataSets)...
April 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29660899/plasma-exosome-levels-in-non-small-cell-lung-cancer-correlation-with-clinicopathological-features-and-prognostic-implications
#18
Qingyun Liu, Ying Xiang, Shuai Yuan, Weijia Xie, Chengying Li, Zeyao Hu, Ying Xiang, Na Wu, Long Wu, Zubin Yu, Li Bai, Yafei Li
BACKGROUND: Biomarker studies revealed important clinical significance of exosome for cancer patients. However, there is currently no consensus on exosome quantification methods. METHODS: Bicinchoninic acid (BCA) method, acetylcholinesterase (AChE) method and nanoparticle tracking analysis (NTA) were utilized to quantify 20 plasma exosome samples, and interrelations between these three methods were explored. Associations of plasma exosome levels with characteristics and prognosis of 208 non-small-cell lung cancer (NSCLC) patients were investigated...
April 3, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29660237/multiplexed-isobaric-tag-based-profiling-of-seven-murine-tissues-following-in-vivo-nicotine-treatment-using-a-minimalistic-proteomics-strategy
#19
Joao A Paulo, Mark P Jedrychowski, Edward T Chouchani, Lawrence Kazak, Steven P Gygi
Nicotine is a major addictive compound in tobacco and a component of smoking-related products, such as e-cigarettes. Once internalized, nicotine can perturb many cellular pathways and can induce alterations in proteins across different cell types, however the mechanisms thereof remain undetermined. We hypothesize that both tissue-specific and global protein abundance alterations result from nicotine exposure. As such, we present the first proteome analysis of multiple tissues from nicotine-exposed mice. We treat mice via oral administration of nicotine at 200μg/mL in drinking water for 21 days...
April 16, 2018: Proteomics
https://www.readbyqxmd.com/read/29650269/current-perspectives-on-the-crosstalk-between-lung-cancer-stem-cells-and-cancer-associated-fibroblasts
#20
REVIEW
Cristina Alguacil-Núñez, Inés Ferrer-Ortiz, Elena García-Verdú, Pilar López-Pirez, Irene Maria Llorente-Cortijo, Bruno Sainz
Lung cancer, in particular non-small cell lung carcinoma (NSCLC), is the second most common cancer in both men and women and the leading cause of cancer-related deaths worldwide. Its prognosis and diagnosis are determined by several driver mutations and diverse risk factors (e.g. smoking). While immunotherapy has proven effective in some patients, treatment of NSCLC using conventional chemotherapy is largely ineffective. The latter is believed to be due to the existence of a subpopulation of stem-like, highly tumorigenic and chemoresistant cells within the tumor population known as cancer stem cells (CSC)...
May 2018: Critical Reviews in Oncology/hematology
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