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https://www.readbyqxmd.com/read/29352721/hyperconnective-and-hypoconnective-cortical-and-subcortical-functional-networks-in-multiple-system-atrophy
#1
Johannes Rosskopf, Martin Gorges, Hans-Peter Müller, Elmar H Pinkhardt, Albert C Ludolph, Jan Kassubek
INTRODUCTION: In multiple system atrophy (MSA), the organization of the functional brain connectivity within cortical and subcortical networks and its clinical correlates remains to be investigated. METHODS: Whole-brain based 'resting-state' fMRI data were obtained from 22 MSA patients (11 MSA-C, 11 MSA-P) and 22 matched healthy controls, together with standardized clinical assessment and video-oculographic recordings (EyeLink®). RESULTS: MSA patients vs...
January 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29345519/-i-just-roll-over-pick-myself-up-and-carry-on-exploring-the-fall-risk-experience-of-canadian-masters-athletes
#2
Dylan Brennan, Aleksandra A Zecevic, Shannon L Sibbald, Volker Nolte
OBJECTIVES: The risk of falling increases in adults over the age of 65. A common barrier to take up physical activity in sedentary older adults is the fear of falls and injury. Experiences of masters athletes can provide insights into management of the risk for falling. The purpose of this phenomenological study was to explore the fall-risk experience of masters athletes actively competing in sport. METHODS: Masters athletes over the age of 55 (n=22) described their experiences in semi-structured interviews...
January 18, 2018: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/29345174/case-study-using-contemporary-behaviour-change-science-to-design-and-implement-an-effective-nutritional-intervention-within-professional-rugby-league
#3
Nessan Costello, Jim McKenna, Louise Sutton, Kevin Deighton, Ben Jones
Designing and implementing successful dietary intervention is integral to the role of sport nutrition professionals as they attempt to positively change the dietary behaviour of athletes. High-performance sport is a time-pressured environment where immediate results can often supersede pursuit of the most effective evidence-based practice. However, efficacious dietary intervention necessitates comprehensive, systematic and theoretical behavioural design and implementation if the habitual dietary behaviours of athletes are to be positively changed...
January 18, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29343159/celebrating-40-years-of-medical-teacher-as-the-last-man-standing-i-look-back-to-help-us-look-forward
#4
Hilliard Jason
INTRODUCTION: In this reflective, descriptive, analytical, first-person piece, I offer recollections, data, and literature to help elucidate the emergence of medical education as a scholarly field, as part of celebrating Medical Teacher's 40-year anniversary. I emphasize the impressive growth of the professional literature in medical education, and recognize that much remains to be done. FINDINGS: Medical education as a domain for research and development has transitioned from being largely ignored during the first 20 of the past 60 years, through a slow growth phase, to rapid acceleration during the last 2 decades...
January 18, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29341514/opportunity-costs-in-paediatric-training-the-specialist-registrars-experience
#5
M B O'Neill, T Nabialek, N Kandamany
In the training process, there is a tension between the work life and home life of trainees. This study explored both the personal impact and the opportunity costs of training from the Specialist Paediatric Registrar (SPR) perspective. The survey explored 1) career progression, 2) perceived functional effectiveness at work, 3) psychological impact of hospital based training, and 4) the personal and social cost of training. Fifty-three (71%) SPRs responded of whom 47 (89%)were married or in long term relationships...
August 8, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29340749/in-pursuit-of-effective-volume-reduction-and-enhanced-aesthetics-for-treatment-of-gigantomastia-using-superior-dermoglandular-pedicle
#6
Betul Gozel Ulusal, Ince Alper
BACKGROUND: Gigantomastia is defined as extreme hypertrophy of the female breast. It is a disabling condition that presents unique challenges to plastic surgeons. Initial breast volume is an important factor affecting the success of the reduction. Usually, it is difficult to achieve small-sized breasts, and long-term results are often unsatisfactory, resulting in complications such as "bottoming-out" deformities. METHODS: This paper presents a case series involving 40 patients (mean age 44...
January 16, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29338548/glycine-transporter-1-inhibitors-a-patent-review-2011-2016
#7
Christopher L Cioffi
Numerous research groups have developed GlyT-1 inhibitors in the pursuit of providing a novel antipsychotic treatment for schizophrenia. Despite multiple compounds advancing into clinical trials, a GlyT-1 inhibitor has yet to emerge to treat patients. However, the approach remains heavily investigated as it presents potential therapeutic utility for several other CNS and non-CNS-related indications. Areas covered: This review discusses various GlyT-1 inhibitor chemotypes identified and provides an overview of patent applications filed and published during the period of 2011-2016...
January 17, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29337922/underdetermined-wideband-doa-estimation-for-off-grid-sources-with-coprime-array-using-sparse-bayesian-learning
#8
Yanhua Qin, Yumin Liu, Jianyi Liu, Zhongyuan Yu
Sparse Bayesian learning (SBL) is applied to the coprime array for underdetermined wideband direction of arrival (DOA) estimation. Using the augmented covariance matrix, the coprime array can achieve a higher number of degrees of freedom (DOFs) to resolve more sources than the number of physical sensors. The sparse-based DOA estimation can deteriorate the detection and estimation performance because the sources may be off the search grid no matter how fine the grid is. This dictionary mismatch problem can be well resolved by the SBL using fixed point updates...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29337535/anion-mediated-photophysical-behavior-in-a-c60-fullerene-3-rotaxane-shuttle
#9
Timothy A Barendt, Ilija Rašović, Maria A Lebedeva, George A Farrow, Alexander Auty, Dimitri Chekulaev, Igor V Sazanovich, Julia A Weinstein, Kyriakos Porfyrakis, Paul D Beer
By addressing the challenge of controlling molecular motion, mechanically interlocked molecular machines are primed for a variety of applications in the field of nanotechnology. Specifically, the designed manipulation of communication pathways between electron donor and acceptor moieties that are strategically integrated into dynamic photoactive rotaxanes and catenanes may lead to efficient artificial photosynthetic devices. In this pursuit, a novel [3]rotaxane molecular shuttle consisting of a four station bis-naphthalene diimide (NDI) and central C60 fullerene bis-triazolium axle component and two mechanically bonded ferrocenyl functionalized -isophthalamide anion binding site-containing macrocycles is constructed using an anion template synthetic methodology...
January 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29335172/preparation-of-amidoxime-functionalized-mesoporous-silica-nanospheres-ami-msn-from-coal-fly-ash-for-the-removal-of-u-vi
#10
Bangda Wang, Yuexi Zhou, Lei Li, Yi Wang
It is usually difficult to control the microstructure of mesoporous silica materials using coal fly ash as raw materials. In this study, amidoxime-functionalized mesoporous silica nanospheres (ami-MSN) were prepared from coal fly ash using a novel interfacial cohydrolysis-condensation method in an alkane-aqueous system. Characterizations suggested a regular microstructure, high specific surface area (676 m2/g) as well as stable and uniformly distributed amidoxime groups in the ami-MSN framework. Furthermore, ami-MSN displays a high U(VI) removal capacity in sorption experiments (98...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29334971/the-titanium-elastic-nail-serves-as-an-alternative-treatment-for-adult-proximal-radial-shaft-fractures-a-cohort-study
#11
Ying-Cheng Huang, Jenn-Huei Renn, Yih-Wen Tarng
BACKGROUND: To investigate whether closed reduction and internal fixation (CRIF) with titanium elastic nails (TENs) is a viable alternative treatment in proximal radial fractures. METHODS: In Kaohsiung Veterans General Hospital, from November 2013 to April 2015, five adult male patients with forearm injuries (average age 43 years; range 35-64 years) were treated for proximal radial shaft fractures. CRIF with TENs for radial shaft fractures was performed in these five patients...
January 15, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29334963/evaluating-the-impact-of-a-falls-prevention-community-of-practice-in-a-residential-aged-care-setting-a-realist-approach
#12
Jacqueline Francis-Coad, Christopher Etherton-Beer, Caroline Bulsara, Nicole Blackburn, Paola Chivers, Anne-Marie Hill
BACKGROUND: Falls are a major socio-economic problem among residential aged care (RAC) populations resulting in high rates of injury including hip fracture. Guidelines recommend that multifactorial prevention strategies are implemented but these require translation into clinical practice. A community of practice (CoP) was selected as a suitable model to support translation of the best available evidence into practice, as it could bring together like-minded people with falls expertise and local clinical knowledge providing a social learning opportunity in the pursuit of a common goal; falls prevention...
January 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29328307/channel-estimation-for-wideband-underwater-visible-light-communication-a-compressive-sensing-perspective
#13
Xu Ma, Fang Yang, Sicong Liu, Jian Song
With the rapid development of light emitting diode (LED), visible light communication (VLC) becomes an important technique for information transmission including underwater applications. However, accurate channel estimation for underwater VLC is still challenging due to the complex environment of the underwater VLC channel. In this paper, by utilizing a proper approximation, where the channel attenuation is linear with the frequency, a new compressive sensing (CS) based channel estimation approach is proposed...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29327174/localized-targeted-antiangiogenic-drug-delivery-for-glioblastoma
#14
REVIEW
Gregory D Arnone, Abhiraj D Bhimani, Tania Aguilar, Ankit I Mehta
Systemic delivery of antiangiogenic agents has been ineffective in improving the overall survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting toxicities. With the development of new and efficient localized delivery methods and vehicles, an otherwise lethal dose of antiangiogenic chemotherapy can be used to treat tumors while minimizing systemic side effects. Current in-vitro and in-vivo animal studies have shown promising results that encourage the pursuit towards human clinical trials for localized antiangiogenic treatment in the near future...
January 11, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29325547/paracrine-and-epigenetic-control-of-caf-induced-metastasis-the-role-of-hotair-stimulated-by-tgf-%C3%A3-1-secretion
#15
Yu Ren, Huan-Huan Jia, Yi-Qi Xu, Xuan Zhou, Xiao-Hui Zhao, Yun-Fei Wang, Xin Song, Zhi-Yan Zhu, Ting Sun, Yan Dou, Wei-Ping Tian, Xiu-Lan Zhao, Chun-Sheng Kang, Mei Mei
BACKGROUND: The communication between carcinoma associated fibroblasts (CAFs) and cancer cells facilitate tumor metastasis. In this study, we further underlying the epigenetic mechanisms of CAFs feed the cancer cells and the molecular mediators involved in these processes. METHODS: MCF-7 and MDA-MB-231 cells were treated with CAFs culture conditioned medium, respectively. Cytokine antibody array, enzyme-linked immunosorbent assay, western blotting and immunofluorescence were used to identify the key chemokines...
January 11, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29324338/identification-of-novel-2-benzoxazolinone-derivatives-with-specific-inhibitory-activity-against-the-hiv-1-nucleocapsid-protein
#16
Elia Gamba, Mattia Mori, Lesia Kovalenko, Alessia Giannini, Alice Sosic, Francesco Saladini, Dan Fabris, Yves Mély, Barbara Gatto, Maurizio Botta
In this report, we present a new benzoxazole derivative endowed with inhibitory activity against the HIV-1 nucleocapsid protein (NC). NC is a 55-residue basic protein with nucleic acid chaperone properties, which has emerged as a novel and potential pharmacological target against HIV-1. In the pursuit of novel NC-inhibitor chemotypes, we performed virtual screening and in vitro biological evaluation of a large library of chemical entities. We found that compounds sharing a benzoxazolinone moiety displayed putative inhibitory properties, which we further investigated by considering a series of chemical analogues...
December 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29319476/canmeds-scholars-a-national-survey-on-urology-residents-attitudes-towards-research-during-training
#17
Ogi Solaja, Thomas A A Skinner, Thomas B Mcgregor, D Robert Siemens
INTRODUCTION: Participation in scholarly activity is an important tenet of residency training and is firmly entrenched in Canada since the introduction of CANMEDS roles by the Royal College of Physicians and Surgeons. As Canadian residency programs transition to competency-based training, it will remain important to understand how to best implement and encourage scholarly pursuits among resident trainees. The objective of this study was to understand the experiences, attitudes, and barriers that surgical residents face when pursuing research during their training...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29319407/malpractice-litigation-in-acute-stroke-care-where-are-we-now
#18
Gilberto Kk Leung, Gerard Porter
Acute stroke care has undergone momentous changes in recent years with the introduction of intravenous thrombolysis, mechanical thrombectomy and integrated stroke services. While these are welcome developments, they also carry unique medico-legal challenges. In 2015, a patient from Greater Manchester was awarded over £1 million in compensation after ambulance paramedics failed to admit her to a specialist unit. This paper explores the medico-legal implications of this first but over looked thrombolysis-related claim in the United Kingdom...
January 1, 2018: Medico-legal Journal
https://www.readbyqxmd.com/read/29318971/-phenserine-and-inhibiting-pre-programmed-cell-death-in-pursuit-of-a-novel-intervention-for-alzheimer-s-disease
#19
Robert E Becker, Nigel H Greig, Debomoy K Lahiri, Joseph Bledsoe, Sarah Majercik, Clive Ballard, Dag Aarsland, Lon S Schneiderh, Douglas Flanagan, Ramprakash Govindarajani, Mary Sano, Luigi Ferrucci, Dimitrios Kapogiannisk
BACKGROUND: Concussion (mild) and other moderate traumatic brain injury (TBI) and Alzheimer's disease (AD) share overlapping neuropathologies, including neuronal pre-programmed cell death (PPCD), and clinical impairments and disabilities. Multiple clinical trials targeting mechanisms based on the Amyloid Hypothesis of AD have so far failed, indicating that it is prudent for new drug developments to also pursue mechanisms independent of the Amyloid Hypothesis. To address these issue, we have proposed the use of an animal model of concussion/TBI as a supplement to AD transgenic mice to provide an indication of an AD drug candidate's potential for preventing PPCD and resulting progression towards dementia in AD...
January 10, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29318245/chemicals-from-lignin-an-interplay-of-lignocellulose-fractionation-depolymerisation-and-upgrading
#20
REVIEW
W Schutyser, T Renders, S Van den Bosch, S-F Koelewijn, G T Beckham, B F Sels
In pursuit of more sustainable and competitive biorefineries, the effective valorisation of lignin is key. An alluring opportunity is the exploitation of lignin as a resource for chemicals. Three technological biorefinery aspects will determine the realisation of a successful lignin-to-chemicals valorisation chain, namely (i) lignocellulose fractionation, (ii) lignin depolymerisation, and (iii) upgrading towards targeted chemicals. This review provides a summary and perspective of the extensive research that has been devoted to each of these three interconnected biorefinery aspects, ranging from industrially well-established techniques to the latest cutting edge innovations...
January 10, 2018: Chemical Society Reviews
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