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https://www.readbyqxmd.com/read/28102796/-nursing-can-t-be-done-alone
#1
Layla Haidrani
When and why did you develop an interest in research? After completing my master's thesis at Emory University in Georgia, United States, I realised that I enjoyed the precise and methodological approach of scientists in their pursuit of answering compelling health problems. I started out interested in children's health and engagement of their families and I have maintained that initial interest in promoting health and preventing disease in children.
January 23, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/28102068/robust-guar-gum-cellulose-nanofibrils-multilayer-films-with-good-barrier-properties
#2
Lei Dai, Zhu Long, Jie Chen, Xingye An, Dong Cheng, Avik Khan, Yonghao Ni
The pursuit of sustainable functional materials requires development of materials based on renewable resources and efficient fabrication methods. Hereby, we fabricated all-polysaccharides multilayer films using cationic guar gum (CGG) and anionic cellulose nanofibrils (i.e. TEMPO-oxidized cellulose nanofibrils, TOCNs) through a layer-by-layer casting method. This technique is based on alternate depositions of oppositely charged water-based CGG and TOCNs onto laminated films. The resultant polyelectrolyte multilayer films were transparent, ductile and strong...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28101524/the-role-of-dopamine-in-anticipatory-pursuit-eye-movements-insights-from-genetic-polymorphisms-in-healthy-adults
#3
Jutta Billino, Jürgen Hennig, Karl R Gegenfurtner
There is a long history of eye movement research in patients with psychiatric diseases for which dysfunctions of neurotransmission are considered to be the major pathologic mechanism. However, neuromodulation of oculomotor control is still hardly understood. We aimed to investigate in particular the impact of dopamine on smooth pursuit eye movements. Systematic variability in dopaminergic transmission due to genetic polymorphisms in healthy subjects offers a noninvasive opportunity to determine functional associations...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28101131/using-flow-technologies-to-direct-the-synthesis-and-assembly-of-materials-in-solution
#4
REVIEW
K Robertson
In the pursuit of materials with structure-related function, directing the assembly of materials is paramount. The resultant structure can be controlled by ordering of reactants, spatial confinement and control over the reaction/crystallisation times and stoichiometries. These conditions can be administered through the use of flow technologies as evidenced by the growing widespread application of microfluidics for the production of nanomaterials; the function of which is often dictated or circumscribed by size...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28098821/tumor-microenvironment-modulation-via-gold-nanoparticles-targeting-malicious-exosomes-implications-for-cancer-diagnostics-and-therapy
#5
REVIEW
Catarina Roma-Rodrigues, Luís R Raposo, Rita Cabral, Fabiana Paradinha, Pedro V Baptista, Alexandra R Fernandes
Exosomes are nanovesicles formed in the endosomal pathway with an important role in paracrine and autocrine cell communication. Exosomes secreted by cancer cells, malicious exosomes, have important roles in tumor microenvironment maturation and cancer progression. The knowledge of the role of exosomes in tumorigenesis prompted a new era in cancer diagnostics and therapy, taking advantage of the use of circulating exosomes as tumor biomarkers due to their stability in body fluids and targeting malignant exosomes' release and/or uptake to inhibit or delay tumor development...
January 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098572/metastatic-organotropism-an-intrinsic-property-of-breast-cancer-molecular-subtypes
#6
Shi Wei, Gene P Siegal
It has long been known that some cancers have the propensity to metastasize to certain organs thus creating a nonrandom distribution of sites for distant relapse, a phenomenon known as "metastatic organotropism." Some of these examples include ovary primary to abdominal cavity, prostate primary to bone, and pancreas primary to liver. In contrast, other tumor types, such as mammary and renal cell carcinoma, can relapse in multiple organs although approximately half of advanced breast cancers metastasize to bone...
January 16, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28097765/a-false-positive-screening-hit-in-fragment-based-lead-discovery-watch-out-for-the-red-herring
#7
Jonathan Cramer, Johannes Schiebel, Tobias Wulsdorf, Kristof Grohe, Eszter Eva Najbauer, Frederik R Ehrmann, Nedyalka Radeva, Nina Zitzer, Uwe Linne, Rasmus Linser, Andreas Heine, Gerhard Klebe
With the rising popularity of fragment-based approaches in drug development, more and more attention has to be devoted to the detection of false-positive screening results. In particular, the small size and low affinity of fragments drives screening techniques to their limit. The pursuit of a false-positive hit can cause significant loss of time and resources. Here, we present an instructive and intriguing investigation into the origin of misleading assay results for a fragment that emerged as the most potent binder for the aspartic protease endothiapepsin (EP) across multiple screening assays...
January 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28097075/effects-of-an-8-week-yoga-program-on-sustained-attention-and-discrimination-function-in-children-with-attention-deficit-hyperactivity-disorder
#8
Chien-Chih Chou, Chung-Ju Huang
This study investigated whether a yoga exercise intervention influenced the sustained attention and discrimination function in children with ADHD. Forty-nine participants (mean age = 10.50 years) were assigned to either a yoga exercise or a control group. Participants were given the Visual Pursuit Test and Determination Test prior to and after an eight-week exercise intervention (twice per week, 40 min per session) or a control intervention. Significant improvements in accuracy rate and reaction time of the two tests were observed over time in the exercise group compared with the control group...
2017: PeerJ
https://www.readbyqxmd.com/read/28096393/utility-value-intervention-with-parents-increases-students-stem-preparation-and-career-pursuit
#9
Christopher S Rozek, Ryan C Svoboda, Judith M Harackiewicz, Chris S Hulleman, Janet S Hyde
During high school, developing competence in science, technology, engineering, and mathematics (STEM) is critically important as preparation to pursue STEM careers, yet students in the United States lag behind other countries, ranking 35th in mathematics and 27th in science achievement internationally. Given the importance of STEM careers as drivers of modern economies, this deficiency in preparation for STEM careers threatens the United States' continued economic progress. In the present study, we evaluated the long-term effects of a theory-based intervention designed to help parents convey the importance of mathematics and science courses to their high-school-aged children...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096240/coevolution-of-leukemia-and-host-immune-cells-in-chronic-lymphocytic-leukemia
#10
Noelia Purroy, C J Wu
Cumulative studies on the dissection of changes in driver genetic lesions in cancer across the course of the disease have provided powerful insights into the adaptive mechanisms of tumors in response to the selective pressures of therapy and environmental changes. In particular, the advent of next-generation-sequencing (NGS)-based technologies and its implementation for the large-scale comprehensive analyses of cancers have greatly advanced our understanding of cancer as a complex dynamic system wherein genetically distinct subclones interact and compete during tumor evolution...
January 17, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28095853/crispri-mediated-metabolic-engineering-of-e-coli-for-o-methylated-anthocyanin-production
#11
Brady F Cress, Quentin D Leitz, Daniel C Kim, Teresita D Amore, Jon Y Suzuki, Robert J Linhardt, Mattheos A G Koffas
BACKGROUND: Anthocyanins are a class of brightly colored, glycosylated flavonoid pigments that imbue their flower and fruit host tissues with hues of predominantly red, orange, purple, and blue. Although all anthocyanins exhibit pH-responsive photochemical changes, distinct structural decorations on the core anthocyanin skeleton also cause dramatic color shifts, in addition to improved stabilities and unique pharmacological properties. In this work, we report for the first time the extension of the reconstituted plant anthocyanin pathway from (+)-catechin to O-methylated anthocyanins in a microbial production system, an effort which requires simultaneous co-option of the endogenous metabolites UDP-glucose and S-adenosyl-L-methionine (SAM or AdoMet)...
January 17, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28093878/in-pursuit-of-greater-reproducibility-and-credibility-of-early-clinical-biomarker-research
#12
Lisa M McShane
Biomarkers underlie many clinical tests that are integral to the practice of personalized medicine. Reproducibility and scientific credibility of clinical biomarker early development studies are critical to avoid advancing worthless or potentially harmful biomarker-based tests into late phase clinical studies and clinical practice. This commentary discusses key aspects to consider when conducting and evaluating early clinical biomarker research. Greater attention to these aspects would enhance research reproducibility and better prioritize biomarkers for further clinical development...
January 16, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28092077/the-reference-frame-for-encoding-and-retention-of-motion-depends-on-stimulus-set-size
#13
Duong Huynh, Srimant P Tripathy, Harold E Bedell, Haluk Öğmen
The goal of this study was to investigate the reference frames used in perceptual encoding and storage of visual motion information. In our experiments, observers viewed multiple moving objects and reported the direction of motion of a randomly selected item. Using a vector-decomposition technique, we computed performance during smooth pursuit with respect to a spatiotopic (nonretinotopic) and to a retinotopic component and compared them with performance during fixation, which served as the baseline. For the stimulus encoding stage, which precedes memory, we found that the reference frame depends on the stimulus set size...
January 13, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28091557/the-same-oculomotor-vermal-purkinje-cells-encode-the-different-kinematics-of-saccades-and-of-smooth-pursuit-eye-movements
#14
Zongpeng Sun, Aleksandra Smilgin, Marc Junker, Peter W Dicke, Peter Thier
Saccades and smooth pursuit eye movements (SPEM) are two types of goal-directed eye movements whose kinematics differ profoundly, a fact that may have contributed to the notion that the underlying cerebellar substrates are separated. However, it is suggested that some Purkinje cells (PCs) in the oculomotor vermis (OMV) of monkey cerebellum may be involved in both saccades and SPEM, a puzzling finding in view of the different kinematic demands of the two types of eye movements. Such 'dual' OMV PCs might be oddities with little if any functional relevance...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28089280/financial-hardship-on-the-path-to-universal-health-coverage-in-the-gulf-states
#15
Riyadh Alshamsan, Hannah Leslie, Azeem Majeed, Margaret Kruk
BACKGROUND: Countries globally are pursuing universal health coverage to ensure better healthcare for their populations and prevent households from catastrophic expenditure. The countries of the Gulf Cooperation Council (GCC) have and continue to implement reforms to strengthen their health systems. A common theme between the countries is their pursuit of universal health coverage to provide access to necessary health care without exposing people to financial hardship. METHODS: Using nationally representative data from the Global Findex study, we sought to analyze the hardship faced by individuals from four high-income countries in the GCC...
January 7, 2017: Health Policy
https://www.readbyqxmd.com/read/28088068/perceived-assistance-in-pursuing-personal-goals-and-personal-recovery-among-mental-health-consumers-across-housing-services
#16
Galia S Moran, Kinneret Westman, Esther Weissberg, Samuel Melamed
Personal goals/plans play a central role in personal recovery and psychiatric rehabilitation of persons with mental illnesses. Yet, few studies have explored whether perceiving practitioners' assistance towards the pursuit of goals are associated with personal recovery and other favorable rehabilitation outcomes. A total of 2121 mental health consumers, of which 1222 use supported-housing services and 899 use group-home services, completed self-report questionnaires as part of a larger quality-assurance study conducted during the years 2013-2014...
January 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28078948/care-seeking-for-children-with-fever-cough-or-diarrhoea-in-nepal-equity-trends-over-the-last-15-years
#17
Mats Målqvist, Chahana Singh, Ashish Kc
AIMS: Childhood illnesses such as diarrhoea and pneumonia remain major contributors to child mortality globally and need to be continually targeted in pursuit of universal health coverage. This study analyses time trends in the prevalence of fever/cough and diarrhoea in Nepal and applies an equity lens in order to identify disadvantaged groups. METHODS: Data from the Nepal Demographic Health Surveys of 2001, 2006, and 2011, together with data from the most recent Multiple Indicator Cluster Survey of 2014 performed in Nepal, were utilized for analysis...
January 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28076995/biosurfactants-in-cosmetic-formulations-trends-and-challenges
#18
X Vecino, J M Cruz, A B Moldes, L R Rodrigues
Cosmetic products play an essential role in everyone's life. People everyday use a large variety of cosmetic products such as soap, shampoo, toothpaste, deodorant, skin care, perfume, make-up, among others. The cosmetic industry encompasses several environmental, social and economic impacts that are being addressed through the search for more efficient manufacturing techniques, the reduction of waste and emissions and the promotion of personal hygiene, contributing to an improvement of public health and at the same time providing employment opportunities...
January 12, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28075492/a-thematic-content-analysis-of-cheatmeal-images-on-social-media-characterizing-an-emerging-dietary-trend
#19
Eva Pila, Jonathan M Mond, Scott Griffiths, Deborah Mitchison, Stuart B Murray
Despite the pervasive social endorsement of "cheat meals" within pro-muscularity online communities, there is an absence of empirical work examining this dietary phenomenon. The present study aimed to characterize cheat meals, and explore the meaning ascribed to engagement in this practice. Thematic content analysis was employed to code the photographic and textual elements of a sample (n = 600) that was extracted from over 1.6 million images marked with the #cheatmeal tag on the social networking site, Instagram...
January 11, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28075128/pursuit-of-record-breaking-energy-barriers-a-study-of-magnetic-axiality-in-diamide-ligated-dy-iii-single-molecule-magnets
#20
Katie L M Harriman, Jonathan L Brosmer, Liviu Ungur, Paula L Diaconescu, Muralee Murugesu
Dy(III) single-ion magnets (SIMs) with strong axial donors and weak equatorial ligands are attractive model systems with which to harness the maximum magnetic anisotropy of Dy(III) ions. Utilizing a rigid ferrocene diamide ligand (NN(TBS)), a Dy(III) SIM, (NN(TBS))DyI(THF)2, 1-Dy (NN(TBS) = fc(NHSitBuMe2)2, fc = 1,1'-ferrocenediyl), composed of a near linear arrangement of donor atoms, exhibits a large energy barrier to spin reversal (770.8 K) and magnetic blocking (14 K). The effects of the transverse ligands on the magnetic and electronic structure of 1-Dy were investigated through ab initio methods, eliciting significant magnetic axiality, even in the fourth Kramers doublet, thus demonstrating the potential of rigid diamide ligands in the design of new SIMs with defined magnetic axiality...
January 17, 2017: Journal of the American Chemical Society
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