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https://www.readbyqxmd.com/read/29150724/presence-of-chlamydia-trachomatis-and-mycoplasma-spp-but-not-neisseria-gonorrhoeae-and-treponema-pallidum-in-women-undergoing-an-infertility-evaluation-high-prevalence-of-tetracycline-resistance-gene-tet-m
#1
Min Li, Xiaomei Zhang, Ke Huang, Haixiang Qiu, Jilei Zhang, Yuan Kang, Chengming Wang
Chlamydia trachomatis, Mycoplasma spp., Neisseria gonorrhoeae and Treponema pallidum are sexually transmitted pathogens that threaten reproductive health worldwide. In this study, vaginal swabs obtained from women (n = 133) that attended an infertility clinic in China were tested with qPCRs for C. trachomatis, Mycoplasma spp., N. gonorrhoeae, T. pallidum and tetracycline resistance genes. While none of vaginal swabs were positive for N. gonorrhoeae and T. pallidum, 18.8% (25/133) of the swabs were positive for Chlamydia spp...
November 17, 2017: AMB Express
https://www.readbyqxmd.com/read/29149878/assessing-the-delivery-of-alcohol-screening-and-brief-intervention-in-sexual-health-clinics-in-the-north-east-of-england
#2
C Sullivan, N Martin, C White, D Newbury-Birch
BACKGROUND: Risky drinking is associated with risky sexual experiences, however the relationship between alcohol and sex is complex. The aim of the study was to assess the feasibility of delivering alcohol screening and brief interventions in genitourinary medicine (GUM) clinics. The objectives were to; understand the levels of alcohol use amongst patients; report on the number of alcohol interventions delivered; and to analyse the relationship between alcohol use with demographic data as well as diagnosed sexually transmitted infections (STIs) to see if there were any associations...
November 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29148839/sexual-risk-behaviors-and-perceptions-of-men-who-go-to-gay-sex-parties-in-new-york-city-comparisons-between-three-hiv-groups
#3
Étienne Meunier, Karolynn Siegel
Men who have sex with men (MSM) who attend group-sex events often engage in risky sexual behaviors that contribute to the high human immunodeficiency virus (HIV) incidence among this population. We conducted an online survey with 211 New York City MSM who attended sex parties in the prior year and asked them to describe their behaviors and perceptions of risk. We compared responses from HIV-positive-undetectable men (n = 36), HIV-negative men on pre-exposure prophylaxis (PrEP; n = 62), and HIV-negative men never on PrEP (n = 113)...
November 17, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29146122/health-and-wellbeing-of-indigenous-adolescents-in-australia-a-systematic-synthesis-of-population-data
#4
Peter S Azzopardi, Susan M Sawyer, John B Carlin, Louisa Degenhardt, Ngiare Brown, Alex D Brown, George C Patton
BACKGROUND: Indigenous populations have high rates of disease and premature mortality. Most Indigenous communities are young, and adolescence (age 10-24 years) provides great opportunities for population health gain. However, the absence of a comprehensive account of Indigenous adolescents' health has been a barrier to effective policy. We aimed to report a national health profile for Indigenous adolescents in Australia. METHODS: We undertook a systematic synthesis of population data to report the health and wellbeing of Indigenous adolescents in Australia...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29142126/hpv-replication-regulation-by-acetylation-of-a-conserved-lysine-in-the-e2-protein
#5
Yanique Thomas, Elliot J Androphy
The Papillomavirus (PV) E2 protein is a sequence specific DNA binding protein that recruits cellular factors to its genome in infected epithelial cells. E2 also binds to and loads the viral E1 DNA helicase at the origin of replication. Post-translational modifications (PTMs) of PV E2 have been identified as potential regulators E2 functions. We recently reported lysine (K) 111 as a target of p300 acetylation in bovine (B)PV. The di-lysines at 111 and 112 are conserved in almost all papillomaviruses. We pursued a mutational approach to query the functional significance of lysine in human (H)PV E2...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29141635/repeat-testing-for-chlamydia-trachomatis-a-safe-approach-to-unsafe-sex-a-qualitative-exploration-among-youth-in-stockholm
#6
Anna Nielsen, Ayesha De Costa, Kristina Gemzell Danielsson, Mariano Salazar
BACKGROUND: Chlamydia trachomatis testing is offered to youth in Sweden, through a network of Youth Health Clinics, free at the point of care, in an attempt to bring down the prevalence and incidence of the infection. Nevertheless, infections rates have continued to rise during the past two decades and re-testing rates among youth for Chlamydia trachomatis has been reported to be high in Stockholm County. A few literature reports suggest that testing for sexually transmitted infections and the test result itself can have an undesirable impact on the sexual behaviour for the individual, i...
November 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29141014/prevalence-and-risk-factors-of-anal-human-papillomavirus-infection-among-hiv-negative-men-who-have-sex-with-men-in-urumqi-city-of-xinjiang-uyghur-autonomous-region-china
#7
Tian Tian, Peierdun Mijiti, Huang Bingxue, Zhang Fadong, Abidan Ainiwaer, Sang Guoyao, Zhang Zhanlin, Yeledan Mahan, Tuo Xiaoqin, Gong Zheng, Dai Jianghong
BACKGROUND: Infection with human papillomavirus (HPV) is the most common sexually transmitted infection among men who have sex with men (MSM). Study on prevalence and risk factors of anal HPV infection among HIV-negative MSM in Northwestern China was rare. METHODS: We performed a cross-sectional study of HPV prevalence using anal swab specimens among HIV-negative MSM in Urumqi city of Xinjiang Uyghur Autonomous Region, China between April 1st and October 30th in 2016...
2017: PloS One
https://www.readbyqxmd.com/read/29140439/bivalent-vaccine-effectiveness-against-type-specific-hpv-positivity-evidence-for-cross-protection-against-oncogenic-types-among-dutch-sti-clinic-visitors
#8
Petra J Woestenberg, Audrey J King, Birgit H B van Benthem, Robine Donken, Suzan Leussink, Fiona R M van der Klis, Hester E de Melker, Marianne A B van der Sande, Christian J P A Hoebe, Johannes A Bogaards
Background: Observational post-marketing studies are important to assess vaccine effectiveness (VE). We estimated VE from the bivalent human papillomavirus (HPV) vaccine against HPV positivity of vaccine and non-vaccine types in a high-risk population. Methods: We included all vaccine-eligible women from the PASSYON study, a biennial cross-sectional survey in Dutch sexually transmitted infection clinics. Vaginal swabs were analyzed using a PCR-based assay (SPF10-LiPA25) able to detect the 12 high-risk HPV (hrHPV) types 16/18/31/33/35/39/45/51/52/56/58/59...
November 11, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29139030/potential-risk-factors-for-reactive-arthritis-and-persistence-of-symptoms-at-2%C3%A2-years-a-case-control-study-with-longitudinal-follow-up
#9
Helga Raquel Garcia Ferrer, Alexander Azan, Isa Iraheta, Joan Von Feldt, Luis R Espinoza, Julia Manasson, Jose U Scher, Abraham Garcia Kutzbach, Alexis Ogdie
The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 months prior to study entry were prospectively enrolled in Guatemala City. ReA patients fulfilled the Assessment in Spondyloarthritis International Society criteria for peripheral spondyloarthropathy (SpA)...
November 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29136021/saturation-effects-and-the-concurrency-hypothesis-insights-from-an-analytic-model
#10
Joel C Miller, Anja C Slim
Sexual partnerships that overlap in time (concurrent relationships) may play a significant role in the HIV epidemic, but the precise effect is unclear. We derive edge-based compartmental models of disease spread in idealized dynamic populations with and without concurrency to allow for an investigation of its effects. Our models assume that partnerships change in time and individuals enter and leave the at-risk population. Infected individuals transmit at a constant per-partnership rate to their susceptible partners...
2017: PloS One
https://www.readbyqxmd.com/read/29135564/bacterial-vaginosis-a-practical-review
#11
Paulette Bagnall, Denise Rizzolo
Bacterial vaginosis is a common vaginal infection that causes discharge, odor, and irritation. It can predispose women to sexually transmitted infections (STIs) including HIV. Recurrent bacterial vaginosis may require prolonged treatment to return the vaginal flora to a normal predominately lactobacillidominated environment.
November 9, 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29135519/syphilis-of-the-aerodigestive-tract
#12
Julie Y Tse, May P Chan, Judith A Ferry, Vikram Deshpande, Aliyah R Sohani, Valentina Nardi, Andras Schaffer, Rosalynn M Nazarian, Lawrence R Zukerberg
Syphilis, a sexually transmitted infection caused by the Gram-negative bacterium Treponema pallidum, is increasing in prevalence in the United States. It has been our experience that primary and secondary syphilis of the aerodigestive tract can afflict a large age spectrum with varied clinical and histopathologic findings, which can lead to diagnostic problems and frequent misdiagnosis. In this study, we describe the histopathologic patterns of syphilis of the aerodigestive tract to expand awareness of its varied appearance...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29134421/relationship-between-childhood-sexual-abuse-and-hiv-related-risks-among-men-who-have-sex-with-men-findings-from-mainland-china
#13
Wenjian Xu, Lijun Zheng, Jingjing Song, Xing Zhang, Xuemeng Zhang, Yong Zheng
Men who have sex with men (MSM) carry the burden of HIV infection in China. Outside of China, a history of childhood sexual abuse (CSA) has been associated with HIV-related risks (behavioral, sexual, and mental health outcomes) among MSM. We therefore evaluated the relationship between CSA and these HIV-related risks among MSM in China. Cross-sectional data were collected via a survey from gay websites and social networking applications from MSM in 30 provinces in mainland China during a 3-month period in 2014 and 2015...
November 13, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29132924/impact-of-capsaicin-an-active-component-of-chili-pepper-on-pathogenic-chlamydial-growth-chlamydia-trachomatis-and-chlamydia-pneumoniae-in-immortal-human-epithelial-hela-cells
#14
Kazuya Yamakawa, Junji Matsuo, Torahiko Okubo, Shinji Nakamura, Hiroyuki Yamaguchi
Chlamydia trachomatis is the leading cause of sexually transmitted infections worldwide. Capsaicin, a component of chili pepper, which can stimulate actin remodeling via capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) and anti-inflammatory effects via PPARγ (peroxisome proliferator-activated receptor-γ) and LXRα (liver X receptor α), is a potential candidate to control chlamydial growth in host cells. We examined whether capsaicin could inhibit C. trachomatis growth in immortal human epithelial HeLa cells...
November 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29132441/early-screening-for-chlamydia-trachomatis-in-young-women-for-primary-prevention-of-pelvic-inflammatory-disease-i-predict-study-protocol-for-a-randomised-controlled-trial
#15
Jeanne Tamarelle, Anne C M Thiébaut, Bénédicte Sabin, Cécile Bébéar, Philippe Judlin, Arnaud Fauconnier, Delphine Rahib, Layidé Méaude-Roufai, Jacques Ravel, Servaas A Morré, Bertille de Barbeyrac, Elisabeth Delarocque-Astagneau
BACKGROUND: Genital infection with Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection, especially among young women. Mostly asymptomatic, it can lead, if untreated, to pelvic inflammatory disease (PID), tubal factor infertility and ectopic pregnancy. Recent data suggest that Ct infections are not controlled in France and in Europe. The effectiveness of a systematic strategy for Ct screening in under-25 women remains controversial. The main objective of the i-Predict trial (Prevention of Diseases Induced by Chlamydia trachomatis) is to determine whether early screening and treatment of 18- to-24-year-old women for genital Ct infection reduces the incidence of PID over 24 months...
November 13, 2017: Trials
https://www.readbyqxmd.com/read/29131695/time-since-first-acting-on-same-sex-attraction-and-recreational-drug-use-among-men-who-have-sex-with-men-msm-is-there-an-effect-of-gay-age
#16
Cara E Rice, Sara A Vasilenko, Stephanie T Lanza, John A Davis, Karen S Fields, Melissa Ervin, Abigail Norris Turner
BACKGROUND: Men who have sex with men (MSM) have higher rates of substance use compared to men who have sex with women. Among MSM, drug use is linked to higher-risk sexual behavior and acquisition of HIV and other sexually transmitted infections. OBJECTIVES: We hypothesize that time since first acting on one's same sex attraction, or one's "gay age", could be predictive of drug using behavior. METHODS: We examined this question among 176 MSM, aged 18-35, presenting at a public sexual health clinic...
November 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29130407/hiv-and-other-stis-in-male-sex-workers-findings-from-a-sexual-health-promotion-intervention-in-vietnam
#17
Lloyd A Goldsamt, Michael C Clatts, Le Minh Giang, Bao Q Le, Donn J Colby, Gary Yu
Male sex workers (MSWs) in Vietnam are at high risk for acquisition and transmission of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs), yet are extremely disengaged from the healthcare system. This contributes to large numbers of untreated or late-treated infections and increased secondary transmission. We enrolled 995 MSWs in Hanoi and Ho Chi Minh City (HCMC) in a Sexual Health Promotion intervention that included face-to-face delivery of seven content modules, a clinical examination and testing for HIV, syphilis, gonorrhea and Chlamydia...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29128125/-diagnostic-issues-of-lymphogranuloma-venereum-a-case-series-of-5%C3%A2-patients
#18
A Fabre-Baudouin, A L Roux, C Marin, M Lachatre, M De Laroche, M Ponsoye, T Hanslik, S Trad
INTRODUCTION: Lymphogranuloma venereum (LG) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis L serovar. METHODS: These five consecutive cases aim to highlight the risk of LG misdiagnosis, in case of initial presentation with isolated inguinal adenitis. RESULTS: Five men (mean age: 30±7 years) were seen in an internal medicine department, for inguinal adenopathy. One patient had clinical signs of urethritis. None presented an associated rectitis...
November 8, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29125715/two-phase-1-open-label-single-dose-randomized-crossover-studies-to-assess-the-pharmacokinetics-safety-and-tolerability-of-orally-administered-granules-of-secnidazole-2-g-in-healthy-female-volunteers-under-different-administration-conditions
#19
Helen S Pentikis, Nikki Adetoro
Bacterial vaginosis (BV) is the most common vaginal infection in reproductive-age women and a significant risk factor for sexually transmitted diseases and pregnancy complications. Standard 5- to 7-day antimicrobial treatments for BV are associated with high rates of recurrence and adverse events. SYM-1219 is a novel granule formulation containing 2 g of secnidazole, developed as an oral, single-dose BV treatment. Two phase 1, open-label, single-center, randomized, crossover trials (studies 102 and 103) assessed the pharmacokinetics and safety of SYM-1219 single doses (≥7-day washout between doses) in healthy, nonpregnant women aged 18 to 65 years inclusive...
November 10, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29124332/sexually-transmitted-infections-of-the-lower-gastrointestinal-tract
#20
Rahul Jawale, Keith K Lai, Laura W Lamps
The World Health Organization estimates that there is greater than one million new cases of sexually transmitted infections (STIs) every day. In many countries, STIs are at an unprecedented high, including the USA, where nearly 20 million new cases were reported in 2016. Although morbidity associated with STIs is usually seen in the context of genitourinary disease, these pathogens may also affect the gastrointestinal tract and cause anal pain, abdominal pain, or diarrhea. It is important to recognize patterns of injury associated with these pathogens, especially those that may mimic other gastrointestinal diseases, such as idiopathic inflammatory bowel disease (IBD)...
November 9, 2017: Virchows Archiv: An International Journal of Pathology
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