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Sex and the Elderly

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https://www.readbyqxmd.com/read/28527959/systemic-treatment-patterns-with-advanced-or-recurrent-non-small-cell-lung-cancer-in-japan-a-retrospective-hospital-administrative-database-study
#1
Feng Wang, Sari Mishina, Shinji Takai, T Kim Le, Kenya Ochi, Kotaro Funato, Shozo Matsuoka, Yuichiro Ohe
PURPOSE: Data on the treatment of non-small cell lung cancer (NSCLC) in real-world clinical practice in Japan are limited. This large-scale, retrospective cohort study examined data on patients' characteristics and systemic therapies for advanced or recurrent NSCLC in routine practice in Japan. METHODS: This study used an electronic health records-based database of health claims and Diagnosis Procedure Combination data from 215 consenting hospitals in Japan. Records from April 2008 to September 2015 were analyzed...
May 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28523253/cell-therapy-products-in-alzheimer-disease
#2
REVIEW
Hyeon Jin Song, Tae-Hee Kim, Hae-Hyeog Lee, Jun-Mo Kim, Yoo Jin Park, Arum Lee, Soo Ah Kim, Hye Ji Choi
We are rapidly becoming an aging society, with the ongoing increase in challenges of the elderly. The age-related cognitive decline in accordance with aging society is of major importance in public health. Recent studies have proved the impacts of sex-steroid hormone on the brain; compliant with aging, menopause and decrease in estrogen have an effect on the occurrence and prevention of Alzheimer's disease. A new hypothesis states that Alzheimer's disease is a postmenopausal dementia, and is a negative form of estrogen deficiency...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28523252/prevalence-of-sarcopenia-in-the-world-a-systematic-review-and-meta-analysis-of-general-population-studies
#3
REVIEW
Gita Shafiee, Abbasali Keshtkar, Akbar Soltani, Zeinab Ahadi, Bagher Larijani, Ramin Heshmat
BACKGROUND: Sarcopenia, an age-related decline in muscle mass and function, is one of the most important health problems in elderly with a high rate of adverse outcomes. However, several studies have investigated the prevalence of sarcopenia in the world, the results have been inconsistent. The current systematic review and meta- analysis study was conducted to estimate the overall prevalence of sarcopenia in both genders in different regions of the world. METHODS: Electronic databases, including MEDLINE (via PubMed), SCOPUS and Web of Science were searched between January 2009 and December 2016...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28522384/usefulness-of-d-dimer-testing-in-predicting-recurrence-in-elderly-patients-with-unprovoked-venous-thromboembolism
#4
T Tritschler, A Limacher, M Méan, N Rodondi, D Aujesky
BACKGROUND: Whether post-anticoagulation D-dimer levels are useful in predicting recurrence in elderly patients with unprovoked venous thromboembolism is unknown. METHODS: We followed-up 157 patients aged ≥65 years with acute symptomatic unprovoked venous thromboembolism in a prospective multicenter cohort study. All patients completed 3-12 months of anticoagulation and then underwent quantitative D-dimer testing (ELISA, VIDAS DD) 12 months after the index venous thromboembolism...
May 15, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28520234/bullous-pemphigoid-associated-with-dipeptidyl-peptidase-4-inhibitors-a-report-of-five-cases
#5
Satoshi Yoshiji, Takaaki Murakami, Shin-Ichi Harashima, Rie Ko, Riko Kashima, Daisuke Yabe, Masahito Ogura, Kentaro Doi, Nobuya Inagaki
Bullous pemphigoid (BP) is an autoimmune blistering skin disorder. Recently, BP induced by dipeptidyl peptidase-4 (DPP-4) inhibitors has been a concern. Although DPP-4 inhibitors are commonly used in the Asian population due to their safety and efficacy, BP associated with DPP-4 inhibitors is sometimes seen in clinical settings. Here we report five Japanese cases of BP associated with the agents. In our cases, BP occurred in the elderly by 4 different DPP-4 inhibitors, which showed various clinical manifestations in terms of latency period for BP, sex, glycemic control, and diabetes duration...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28509794/an-allometric-model-of-remifentanil-pharmacokinetics-and-pharmacodynamics
#6
Douglas J Eleveld, Johannes H Proost, Hugo Vereecke, Anthony R Absalom, Erik Olofsen, Jaap Vuyk, Michel M R F Struys
BACKGROUND: Pharmacokinetic and pharmacodynamic models are used to predict and explore drug infusion schemes and their resulting concentration profiles for clinical application. Our aim was to develop a pharmacokinetic-pharmacodynamic model for remifentanil that is accurate in patients with a wide range of age and weight. METHODS: Remifentanil pharmacokinetic data were obtained from three previously published studies of adults and children, one of which also contained pharmacodynamic data from adults...
June 2017: Anesthesiology
https://www.readbyqxmd.com/read/28509689/risk-factors-of-allopurinol-induced-severe-cutaneous-adverse-reactions-in-a-thai-population
#7
Niwat Saksit, Wichittra Tassaneeyakul, Nontaya Nakkam, Parinya Konyoung, Usanee Khunarkornsiri, Pansu Chumworathayi, Chonlaphat Sukasem, Sumitra Suttisai, Napacha Piriyachananusorn, Pawinee Tiwong, Nathorn Chaiyakunapruk, Kittisak Sawanyawisuth, Ticha Rerkpattanapipat, Wongwiwat Tassaneeyakul
BACKGROUND: Allopurinol is one of the most common causes of severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). This study identified the risk factors associated with the development of allopurinol-induced SCARs in a Thai population. PATIENTS AND METHODS: Eighty-six allopurinol-induced SCARs (i.e. 19 DRESS and 67 SJS/TEN) and 182 allopurinol-tolerant patients were enrolled in the study...
May 15, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28509397/sex-differences-in-metabolic-risk-indicator-of-dementia-in-an-elderly-urban-korean-population-a-community-based-cross-sectional-study
#8
Yeon-Ha Kim, Nam Hoon Kim, Moon-Hee Jung, Hee-Jin Kim
AIM: The aim of the present study was to evaluate the age-specific prevalence of dementia, and develop a metabolic risk indicator for dementia according to sex. METHODS: This cross-sectional study was carried out from September 2007 through December 2012 with 19 935 elderly participants in metropolitan Seoul, Korea. Multiphase assessments were used to measure metabolic risk factors and confirm dementia according to sex. Specifically, multivariate logistic regression analyses were used to identify how elderly men and women differed in regard to metabolic risk indicators of dementia...
May 16, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28503508/carbohydrate-composition-associated-with-the-2-year-incidence-of-metabolic-syndrome-in-korean-adults
#9
Nam H Cho, Ara K Cho, Hyun Kyu Kim, Jong Bae Kim, Kyung Eun Lee, Sung Soo Kim, Yeon-Jung Kim, Hak C Jang, Inkyung Baik
The aim of this study was to investigate the association between macronutrient composition and metabolic syndrome (MetS) incidence in Korean adults. Data were obtained from a cohort of 10,030 members aged 40 to 69 years who were enrolled from the 2 cities (Ansung and Ansan) between 2001 and 2002 to participate in the Korean Genome Epidemiology Study. Of these members, 5,565 participants, who were free of MetS and reported no diagnosis of cardiovascular disease at baseline, were included in this study. MetS was defined using the criteria of the National Cholesterol Education Program-Adult Treatment Panel III and Asia-Pacific criteria for waist circumference...
April 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28492994/metabolic-characteristics-and-renal-dysfunction-in-65-patients-with-tophi-prior-to-gout
#10
Chuan-Chin Lu, Shyi-Kuen Wu, Wei-Sheng Chung, Liang-Hung Lin, Ta-Wei Hung, Chih-Jung Yeh
Tophi typically occur many years after uncontrolled gout. Therefore, their development before gout remains unusual. Such patients might exhibit some characteristic differences compared with typical tophaceous gout patients. In this study, 65 tophaceous gout patients with tophi as the first sign of gout (tophi-first group) were enrolled. Their clinical characteristics were compared with those of 1421 patients whose tophi occurred after gout (tophi-after group). Compared with the tophi-after group, the tophi-first group had a significantly higher percentage of female patients and patients with elderly onset of disease and a lower percentage of patients with a positive family history; these patients had lower body mass indices, serum urate levels, and estimated glomerular filtration rates (eGFRs)...
May 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28492770/descriptive-study-on-the-evolution-of-hospitalization-costs-for-ambulatory-care-sensitive-conditions-in-brazil-2000-2013
#11
Dayane Kelle de Souza, Sérgio Viana Peixoto
OBJECTIVE: to analyze the proportions of costs of hospitalizations for ambulatory care sensitive conditions (ACSC) in relation to total hospitalization costs funded by the Brazilian National Health System (SUS) in Brazil, in 2000, 2005, 2010 and 2013, according to sex, age and group of causes. METHODS: this is a descriptive study, with data from SUS Hospital Information System (SIH/SUS); the proportion of hospitalization costs for ACSC was estimated in relation to total hospitalization costs...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28492755/association-between-root-caries-and-depressive-symptoms-among-elders-in-carlos-barbosa-rs-brazil
#12
Otávio Pereira D'Avila, Eliana Wendland, Juliana Balbinot Hilgert, Dalva Maria Pereira Padilha, Fernando Neves Hugo
The aim of this study was to evaluate the association between depressive symptoms and root caries among independent-living older persons. All community-dwelling older adults (not hospitalized and not bedridden) living in Carlos Barbosa, RS, Brazil, were invited to participate, and 785 completed the study protocol (standardized questionnaire assessing socio-demographic information and health behavior, Geriatric Depression Scale [GDS] - brief version, and oral examination [DMFT-Root index, Visible Plaque Index and stimulated salivary flow])...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28488759/association-between-t102c-5-ht2a-receptor-gene-polymorphism-and-5-year-mortality-risk-among-brazilian-amazon-riparian-elderly-population
#13
Tális O Silva, Ivo Jung, Alexis Trott, Cláudia G Bica, Jeferson N Casarin, Paola C Fortuna, Euler E Ribeiro, Fernanda D de Assis, Guilherme C Figueira, Fernanda Barbisan, Maria Fernanda Manica-Cattani, Beatriz S R Bonadiman, Lucien J Houenou, Pedro Antônio S do Prado-Lima, Ivana B M da Cruz
OBJECTIVE: Serotonin (5-HT) is a pleiotropic molecule that exerts several functions on brain and peripheral tissues via different receptors. The gene for the 5-HT2A receptor shows some variations, including a T102C polymorphism, that have been associated with increased risk of neuropsychiatric and vascular disorders. However, the potential impact of 5-HT2A imbalance caused by genetic variations on the human lifespan has not yet been established. METHODS: We performed a prospective study involving an Amazon riparian elderly free-living population in Maués City, Brazil, with a 5-year follow-up...
May 10, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28488262/estimating-the-incidence-of-traumatic-spinal-cord-injuries-in-switzerland-using-administrative-data-to-identify-potential-coverage-error-in-a-cohort-study
#14
Jonviea D Chamberlain, Elias Ronca, Martin Wg Brinkhof
INTRODUCTION: Inferences from population-based cohort studies may be inaccurate as a result of biased coverage of the target population. We investigated the presence of absolute coverage error and selection bias in the Swiss Spinal Cord Injury (SwiSCI) cohort study, using a secondary, nationally representative data source. The proposed methodology is applicable to future Swiss cohort studies aiming to assess their cover-age error. METHODS: ICD-10 codes relating to traumatic spinal cord injuries (TSI) (S14...
May 10, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28486231/decrease-of-horizontal-canal-vestibulo-oculomotor-reflex-gain-in-the-elderly-with-dysequilibrium-without-lifetime-vertigo
#15
Roberto Teggi, Matteo Trimarchi, Omar Gatti, Francesco Fornasari, Mario Bussi
BACKGROUND/AIMS: Unsteadiness in the elderly is a frequent complaint and a strong predictor of falls and psychological distress. Although there is a general consensus that it is a multifactorial condition, recent studies have focused on the role of aging of the vestibular system as a possible cofactor. The aim of our work was to assess horizontal canal function in the elderly. METHODS: We evaluated the gain of horizontal vestibulo-ocular reflex (VOR) with a video head impulse test on a sample of 58 subjects aged >70 years without lifetime episodes of vertigo and correlated the value with different clinical conditions (hypertension, diabetes, prior cardiovascular and vascular disorders of the central nervous system, and falls)...
May 10, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28479968/self-reported-factors-associated-with-engagement-in-moderate-to-vigorous-physical-activity-among-elderly-people-a-population-based-study
#16
Ramin Shiraly, Zahra Shayan, Vahid Keshtkar, Mehdi Hamed
BACKGROUND: Physical activity (PA) typically decreases with aging, especially of moderate to vigorous level, and this change affects health outcomes of older adults. Age-related decline is not evenly distributed across elderly population and is attributed to psychosocial, physical, and environmental determinants. METHODS: We selected a sample of 1000 elderly people from urban parts of Shiraz in Southern Iran with a two-stage random sampling procedure. Self-reported PA data and correlates of moderate to vigorous activity were collected by interview with the respondents from selected households...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28477215/validating-gwas-variants-from-microglial-genes-implicated-in-alzheimer-s-disease
#17
Lígia Ramos Dos Santos, Lúcia Helena Sagrillo Pimassoni, Geralda Gillian Silva Sena, Daniela Camporez, Luciano Belcavello, Maíra Trancozo, Renato Lírio Morelato, Flavia Imbroisi Valle Errera, Maria Rita Passos Bueno, Flavia de Paula
Late-onset Alzheimer's disease (LOAD) is a multifactorial neurodegenerative disorder that corresponds to most Alzheimer's disease (AD) cases. Inflammation is frequently related to AD, whereas microglial cells are the major phagocytes in the brain and mediate the removal of Aβ peptides. Microglial cell dsyregulation might contribute to the formation of amyloid plaques, a hallmark of AD. Genome-wide association studies have reported genetic loci associated with the inflammatory pathway involved in AD. Among them, rs3865444 CD33, rs3764650 ABCA7, rs6656401 CR1, and rs610932 MS4A6A variants in microglial genes are associated with LOAD...
May 5, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28473990/age-and-sex-effects-on-the-active-stiffness-of-vastus-intermedius-under-isometric-contraction
#18
Cong-Zhi Wang, Jing-Yi Guo, Tian-Jie Li, Yongjin Zhou, Wenxiu Shi, Yong-Ping Zheng
Previously, a novel technique was proposed to quantify the relationship between the muscle stiffness and its nonfatigue contraction intensity. The method extended the measured range of isometric contraction to 100% maximum voluntary contraction (MVC) using an ultrasonic shear wave measurement setup. Yet, it has not been revealed how this relationship could be affected by factors like age or sex. To clarify these questions, vastus intermedius (VI) stiffness of 40 healthy subjects was assessed under 11 step levels of isometric contraction...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28473403/performance-of-ahead-score-in-an-asian-cohort-of-acute-heart-failure-with-either-preserved-or-reduced-left-ventricular-systolic-function
#19
Yu-Jen Chen, Shih-Hsien Sung, Hao-Min Cheng, Wei-Ming Huang, Chung-Li Wu, Chi-Jung Huang, Pai-Feng Hsu, Jong-Shiuan Yeh, Chao-Yu Guo, Wen-Chung Yu, Chen-Huan Chen
BACKGROUND: AHEAD (A: atrial fibrillation; H: hemoglobin; E: elderly; A: abnormal renal parameters; D: diabetes mellitus) score has been related to clinical outcomes of acute heart failure. However, the prognostic value of the AHEAD score in acute heart failure patients with either reduced or preserved left ventricular ejection fraction (HFrEF and HFpEF) remain to be elucidated. METHODS AND RESULTS: The study population consisted of 2143 patients (age 77±12 years, 68% men, 38% HFrEF) hospitalized primarily for acute heart failure with a median follow-up of 23...
May 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28470430/is-mortality-due-to-primary-malignant-brain-and-other-central-nervous-system-tumors-decreasing
#20
Haley Gittleman, Courtney Kromer, Quinn T Ostrom, Rachel Blanda, Jeffrey Russell, Carol Kruchko, Jill S Barnholtz-Sloan
Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US) by histology groupings, age, race, and sex. Mortality rates for malignant BT were generated using the Center for Disease Control's National Vital Statistics Systems (NVSS, ~100% of US) data from 1975 to 2012. Histology-specific incidence-based mortality rates were calculated using the National Cancer Institute's Surveillance, Epidemiology, and End-Results 9 (SEER9, ~9...
May 3, 2017: Journal of Neuro-oncology
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