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Sex and the Elderly

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https://www.readbyqxmd.com/read/28732038/analysis-of-patient-data-from-laboratories-during-the-ebola-virus-disease-outbreak-in-liberia-april-2014-to-march-2015
#1
Yuki Furuse, Mosoka Fallah, Hitoshi Oshitani, Ling Kituyi, Nuha Mahmoud, Emmanuel Musa, Alex Gasasira, Tolbert Nyenswah, Bernice Dahn, Luke Bawo
An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended in January 2016. Epidemiological information on the EVD cases was collected and managed nationally; however, collection and management of the data were challenging at the time because surveillance and reporting systems malfunctioned during the outbreak. EVD diagnostic laboratories, however, were able to register basic demographic and clinical information of patients more systematically. Here we present data on 16,370 laboratory samples that were tested between April 4, 2014 and March 29, 2015...
July 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28726047/dietary-acrylamide-exposure-was-associated-with-increased-cancer-mortality-in-chinese-elderly-men-and-women-a-11-year-prospective-study-of-mr-and-ms-os-hong-kong
#2
Zhao-Min Liu, Lap Ah Tse, Suzanne C Ho, Suyang Wu, Bailing Chen, Dicken Chan, Samuel Yeung-Shan Wong
AIM: Our study aims to investigate the association between dietary acrylamide exposure and cancer mortality among Chinese elderly. METHODS: A prospective cohort of 4000 elderly men and women aged 65 years and above (Mr. and Ms. OS Hong Kong study) was recruited from local communities from 2001 to 2003. Dietary exposure to acrylamide was evaluated at baseline based on a validated food frequency questionnaire and an acrylamide database from the 1st Hong Kong Total Diet Study...
July 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28724505/readmission-to-hospital-of-medical-patients-a-cohort-study
#3
Mette Gothardt Rasmussen, Pernille Ravn, Stig Molsted, Lise Tarnow, Susanne Rosthøj
INTRODUCTION: The incidence of acute readmissions is higher among elderly medical patients than in the general population. Risk factor identification is needed in order to prevent readmissions. OBJECTIVE: To estimate the incidence of acute readmissions among medical patients ≥65years discharged from departments of internal medicine and to identify risk factors associated with readmissions. MATERIAL AND METHODS: We included patients discharged between 1st of January 2011 and 1st of December 2014 and collected data regarding primary diagnosis and comorbidities...
July 16, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28724331/randomized-double-blinded-pilot-clinical-study-of-the-antidiabetic-activity-of-balanites-aegyptiaca-and-uplc-esi-ms-ms-identification-of-its-metabolites
#4
Hend Rashad, Fateheya M Metwally, Shahira M Ezzat, Maha M Salama, Adel Hasheesh, Amira Abdel Motaal
CONTEXT: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are traditionally known for the treatment of hyperglycaemia. Several in vitro and in vivo studies proposed some mechanisms of action. However, clinical trials in human beings were never reported to date. OBJECTIVES: To investigate the antidiabetic efficacy of the 70% ethanol extract of the pericarps of B. aegyptiaca (BE) within a nutritional intervention in elderly people. MATERIALS AND METHODS: Ultra-performance electrospray ionization-mass spectroscopy (UPLC-ESI-MS/MS) analysis was used for metabolic profiling of BE which was incorporated in hard gelatine capsules (400 mg/day) and tested on 30 type 2 diabetes (T2D) Egyptian patients for 8 weeks...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28724122/association-between-patient-age-and-lymph-node-positivity-in-thin-melanoma
#5
Andrew J Sinnamon, Madalyn G Neuwirth, Pratyusha Yalamanchi, Phyllis Gimotty, David E Elder, Xiaowei Xu, Rachel R Kelz, Robert E Roses, Emily Y Chu, Michael E Ming, Douglas L Fraker, Giorgos C Karakousis
Importance: More than half of all new melanoma diagnoses present as clinically localized T1 melanoma, yet sentinel lymph node biopsy (SLNB) is controversial in this population given the overall low yield. Guidelines for SLNB have focused on pathologic factors, but patient factors, such as age, are not routinely considered. Objectives: To identify indicators of lymph node (LN) metastasis in thin melanoma in a large, generalizable data set and to evaluate the association between patient age and LN positivity...
July 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28722540/association-between-serum-uric-acid-level-and-hypertension-in-a-chinese-elderly-rural-population
#6
Lei Wu, Yao He, Bin Jiang, Miao Liu, Jianhua Wang, Di Zhang, Yiyan Wang, Jing Zeng
Previous studies have examined the association between elevated serum uric acid (SUA) level and hypertension; however, the association in the Chinese elderly is still uncertain. A cross-sectional study was performed in a rural district of Beijing. A total of 2,397 participants (967 men and 1,430 women) completed the survey. The SUA levels of participants were categorized into four levels using the quartiles (P25, P50, and P75) as cutoff values. Participant was diagnosed as hyperuricemia if the SUA level was ≥417 μmol/L (male) or ≥357 μmol/L (female)...
July 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28719756/medialization-laryngoplasty-in-the-elderly-outcomes-and-expectations
#7
Andrew Jay Bowen, Tiffany L Huang, Michael S Benninger, Paul C Bryson
Objective To describe the profile and outcomes of elderly patients undergoing medialization laryngoplasty for vocal cord paralysis. Study Design Case series with retrospective review. Setting Tertiary care hospital. Subjects and Methods Patients were included in the study if they were >65 years old at the time of medialization laryngoplasty between 2008 and 2015. Patient comorbidities, anticoagulation status, disease etiology, and physical examination findings were recorded with postoperative length of stay, complications, pre- and posttreatment voice outcomes with the Voice Handicap Index (at 6 weeks, 4 months, 8 months, and 1 year), and postprocedural interventions (revision injections, surgery, therapy)...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28714354/is-cerebral-microbleed-prevalence-relevant-as-a-biomarker-in-amnestic-mild-cognitive-impairment-and-mild-alzheimer-s-disease
#8
Ana Gb Rabelo, Camila Vl Teixeira, Thamires Nc Magalhães, Ana Flávia Mk Carletti-Cassani, Augusto Cs Amato Filho, Helena Pg Joaquim, Leda L Talib, Orestes Forlenza, Patrícia Ao Ribeiro, Rodrigo Secolin, Iscia Lopes-Cendes, Fernando Cendes, Marcio Lf Balthazar
Introduction The search for a reliable neuroimaging biomarker in Alzheimer's disease is a matter of intense research. The presence of cerebral microbleeds seems to be a potential biomarker. However, it is not clear if the presence of microbleeds has clinical usefulness to differentiate mild Alzheimer's disease and amnestic mild cognitive impairment from normal aging. We aimed to verify if microbleed prevalence differs among three groups: mild Alzheimer's disease, amnestic mild cognitive impairment due to Alzheimer's disease, and normal controls...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28712959/associations-between-long-term-exposure-to-air-pollution-glycosylated-hemoglobin-and-diabetes
#9
Trenton Honda, Vivian C Pun, Justin Manjourides, Helen Suh
BACKGROUND: Air pollution exposures have been shown to adversely impact health through a number of biological pathways associated with glucose metabolism. However, few studies have evaluated the associations between air pollution and glycosylated hemoglobin (HbA1c) levels. Further, no studies have evaluated these associations in US populations or investigated whether associations differ in diabetic as compared to non-diabetic populations. To address this knowledge gap, we investigated the associations between airborne fine particulate matter (PM2...
June 26, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28709946/frailty-and-sarcopenia-do-not-predict-adverse-events-in-an-elderly-population-undergoing-non-complex-primary-elective-surgery-for-degenerative-conditions-of-the-lumbar-spine
#10
Raphaële Charest-Morin, John Street, Honglin Zhang, Taren Roughead, Tamir Ailon, Michael Boyd, Marcel Dvorak, Brian Kwon, Scott Paquette, Nicolas Dea, Charles G Fisher, Alana M Flexman
BACKGROUND CONTEXT: Sarcopenia measured by normalized total psoas area (NTPA) has been shown to predict mortality and adverse events (AE) in numerous surgical populations. The relationship between sarcopenia and postoperative outcomes after surgery for degenerative spine disease (DSD) has not been investigated. PURPOSE: This study aimed to determine the relationships between sarcopenia, frailty and postoperative adverse events in the elderly DSD population. Secondary objectives were to describe the distribution and predictors of NTPA and to determine the relationship between sarcopenia, frailty and length of stay, discharge to a facility and in-hospital mortality...
July 11, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28709512/correlates-of-sleep-quality-and-sleep-duration-in-a-sample-of-urban-dwelling-elderly-nigerian-women
#11
Michael B Fawale, Isiaka Alani Ismaila, Adekunle F Mustapha, Morenikeji A Komolafe, Olanrewaju Ibigbami
OBJECTIVES: Aging, female sex, and urbanization increase the risk of sleep impairment. Sleep in urban-dwelling elderly African women has been sparsely studied. We studied the characteristics and correlates of sleep quality and habitual sleep duration in a primary care population of urban-living Nigerian women. METHODS: Sleep quality and sleep duration over the previous 1 month were estimated using the Pittsburgh Sleep Quality Index (PSQI). Excessive daytime sleepiness, risk of obstructive sleep apnea (OSA), and depressive symptoms were also assessed...
August 2017: Sleep Health
https://www.readbyqxmd.com/read/28709060/the-association-between-suicidal-ideation-and-sleep-quality-in-elderly-individuals-a-cross-sectional-study-in-shandong-china
#12
Yangyang Qian, Long Sun, Chengchao Zhou, Dandan Ge, Li Zhang
Previous studies have identified global associations between sleep quality and suicidal ideation. However, little is known regarding the relationship between sleep quality and suicidal ideation among Chinese older adults. We examined the relationship between sleep quality and suicidal ideation in older adults in China. A cross-sectional study was conducted in 3313 seniors in Shandong, China. Suicidal ideation was assessed using the interviewees' answers to the question "Have you ever seriously considered wanting to die?"...
July 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28708770/laparoscopic-appendectomy-for-complicated-acute-appendicitis-in-the-elderly-a-single-center-experience
#13
Jiahua Yang, Kun Yu, Wei Li, Xianke Si, Jixun Zhang, Wentao Wu, Yijun Cao
BACKGROUND: The use of laparoscopic appendectomy for complicated acute appendicitis remains controversial in the elderly. This study aimed to compare the postoperative outcomes of elderly patients who received either laparoscopic appendectomy or open appendectomy. PATIENTS AND METHODS: A single-centre retrospective analysis of the clinical records of elderly patients (age, above 65 y) who underwent operations from January 2012 to November 2015 was performed. Demographic data, intraoperative variables, length of stay, and surgical complications were retrieved...
July 13, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28705367/dynamic-magnetic-resonance-imaging-of-the-pelvic-floor
#14
Sindhura Alapati, Kedar Jambhekar
Pelvic floor dysfunction is a widespread condition affecting up to 50% of elderly women. It markedly compromises the quality of life owing to various disabling symptoms such as pelvic pain, pelvic organ prolapse, and urinary and fecal incontinence. Although age and female sex are the main risk factors, others include multiparity, obesity, and connective tissue disorders. Pelvic floor dysfunction is frequently multicompartmental, and failure to diagnose it accurately often leads to treatment failure. Dynamic pelvic floor magnetic resonance imaging is a robust tool that enables simultaneous visualization of the 3 pelvic floor compartments and is indispensable for precise preoperative evaluation...
June 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28705033/differences-in-performance-in-camcog-r-domains-between-old-and-oldest-old-patients-with-alzheimer-s-disease
#15
B Canneti, A J Mosqueira, T Carreras, A B Gago-Veiga, C Onsurbe, M Ruiz, J Vivancos
The purpose of this study is to evaluate the neuropsychological performance in a ≥90-year-old population with Alzheimer disease (AD) in comparison with younger elderly patients. We retrospectively studied all patients with AD attended in a specialized clinic between 1999 and 2011. Age, sex, educational level, and sensory loss data were collected. Neuropsychological evaluation included Mini-Mental State Examination and Global Deterioration Scale. We used the eight Cambridge Cognitive Assessment (CAMCOG-R) domains to evaluate and compare the neuropsychological performance in the younger than 90 years old (<90) and older than 90 years old (≥90) groups...
July 13, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28703888/individual-and-partner-s-level-of-occupation-and-the-association-with-hba1c-levels-in-people-with-type-2-diabetes-mellitus-the-dutch-diabetes-pearl-cohort
#16
A Rutte, S P Rauh, M T Schram, G Nijpels, J H DeVries, F Holleman, H Pijl, O M Dekkers, B Özcan, E J G Sijbrands, C J Tack, E J Abbink, H W de Valk, B Silvius, B H R Wolffenbuttel, C D A Stehouwer, N C Schaper, J M Dekker, J W Beulens, P J M Elders, F Rutters
AIMS: To examine the cross-sectional association between individual/partner's level of occupation with HbA1c levels in people with Type 2 diabetes in the Netherlands. METHODS: We included people with Type 2 diabetes with a partner who were treated in primary, secondary and tertiary care in the Diabetes Pearl cohort. Occupational level was classified according to International Standard Classification of Occupations (ISCO)-08 skill levels. Linear regression analyses were performed stratified for sex, and corrected for age, recruitment centre and diabetes medication...
July 13, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28700591/trends-in-traumatic-brain-injury-mortality-in-china-2006-2013-a-population-based-longitudinal-study
#17
Peixia Cheng, Peng Yin, Peishan Ning, Lijun Wang, Xunjie Cheng, Yunning Liu, David C Schwebel, Jiangmei Liu, Jinlei Qi, Guoqing Hu, Maigeng Zhou
BACKGROUND: Traumatic brain injury (TBI) is a significant global public health problem, but has received minimal attention from researchers and policy-makers in low- and middle-income countries (LMICs). Epidemiological evidence of TBI morbidity and mortality is absent at the national level for most LMICs, including China. Using data from China's Disease Surveillance Points (DSPs) system, we conducted a population-based longitudinal analysis to examine TBI mortality, and mortality differences by sex, age group, location (urban/rural), and external cause of injury, from 1 January 2006 to 31 December 2013 in China...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28699630/prevalence-and-clinical-correlation-of-dysphagia-in-parkinson-disease-a-study-on-chinese-patients
#18
X Ding, J Gao, C Xie, B Xiong, S Wu, Z Cen, Y Lou, D Lou, F Xie, W Luo
BACKGROUND/OBJECTIVES: Dysphagia is relatively common in patients with Parkinson disease (PD) and can have a negative impact on their quality of life; therefore, it is imperative that its prevalence in PD patients is studied. The aim of this study was to explore the prevalence and clinical correlation of dysphagia in Chinese PD patients. SUBJECTS/METHODS: We recruited 116 Chinese PD patients. A videofluoroscopic study of swallowing (VFSS) was used to identify dysphagia...
July 12, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28697562/the-montreal-cognitive-assessment-normative-data-from-a-large-swedish-population-based-cohort
#19
Emma Borland, Katarina Nägga, Peter M Nilsson, Lennart Minthon, Erik D Nilsson, Sebastian Palmqvist
BACKGROUND: The Montreal Cognitive Assessment (MoCA) has a high sensitivity for detecting cognitive dysfunction. Swedish normative data does not exist and international norms are often derived from populations where cognitive impairment has not been screened for and not been thoroughly assessed to exclude subjects with dementia or mild cognitive impairment. OBJECTIVE: To establish norms for MoCA and develop a regression-based norm calculator based on a large, well-examined cohort...
July 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28696433/elevated-plasma-ferritin-in-elderly-individuals-with-high-neocortical-amyloid-%C3%AE-load
#20
K Goozee, P Chatterjee, I James, K Shen, H R Sohrabi, P R Asih, P Dave, C ManYan, K Taddei, S J Ayton, M L Garg, J B Kwok, A I Bush, R Chung, J S Magnussen, R N Martins
Ferritin, an iron storage and regulation protein, has been associated with Alzheimer's disease (AD); however, it has not been investigated in preclinical AD, detected by neocortical amyloid-β load (NAL), before cognitive impairment. Cross-sectional analyses were carried out for plasma and serum ferritin in participants in the Kerr Anglican Retirement Village Initiative in Aging Health cohort. Subjects were aged 65-90 years and were categorized into high and low NAL groups via positron emission tomography using a standard uptake value ratio cutoff=1...
July 11, 2017: Molecular Psychiatry
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