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Sex and the Elderly

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https://www.readbyqxmd.com/read/28238102/prevalence-of-drug-interactions-in-elderly-patients-with-multimorbidity-in-primary-care
#1
Susana Sánchez-Fidalgo, Maria Isabel Guzmán-Ramos, Mercedes Galván-Banqueri, Máximo Bernabeu-Wittel, Bernardo Santos-Ramos
Background Drug interactions (DIs) are a significant cause of medication-related problems. The aging population, high chronic diseases prevalence and polypharmacy are closely associated factors. Aim of the review To study the prevalence, types and associated factors of DIs in multimorbidity patients of over 65 years of age in primary care. Methods Relevant studies on DI prevalence in this population were reviewed in PubMed, Cochrane Library and EMBASE (January 2000-December 2015). Independent variables (duration, target population, age, sex, mean of drugs and diseases, geographical localization, DI databases used and study designs) and dependent variables (prevalence, number of DIs per 100 patients and per patient, number of clinically-relevant DIs per 100 patients, most common DI and associated factors) were classified for each article...
February 25, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28231583/prevalence-of-impaired-kidney-function-in-the-german-elderly-results-from-the-berlin-aging-study-ii-base-ii
#2
Maximilian König, Maik Gollasch, Ilja Demuth, Elisabeth Steinhagen-Thiessen
BACKGROUND: In aging populations with an ever-growing burden of risk factors such as obesity, diabetes, and hypertension, chronic kidney disease (CKD) is on the rise. However, little is known about its exact prevalence among elderly adults, and often albuminuria is not included in the definition of CKD. Moreover, novel equations for the estimated glomerular filtration rate (eGFR) have recently emerged, which have not been applied comprehensively to older adults. Data on CKD awareness among the elderly are sparse...
February 24, 2017: Gerontology
https://www.readbyqxmd.com/read/28230198/longitudinal-association-of-hypertension-and-diabetes-mellitus-with-cognitive-functioning-in-a-general-70-year-old-population-the-sonic-study
#3
Hirochika Ryuno, Kei Kamide, Yasuyuki Gondo, Mai Kabayama, Ryosuke Oguro, Chikako Nakama, Serina Yokoyama, Motonori Nagasawa, Satomi Maeda-Hirao, Yuki Imaizumi, Miyuki Takeya, Hiroko Yamamoto, Masao Takeda, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Ken Sugimoto, Takeshi Nakagawa, Saori Yasumoto, Kazunori Ikebe, Hiroki Inagaki, Yukie Masui, Michiyo Takayama, Yasumichi Arai, Tatsuro Ishizaki, Ryutaro Takahashi, Hiromi Rakugi
Both hypertension and diabetes in middle-aged individuals have been suggested to be predictive indicators of cognitive decline. However, the association of hypertension, diabetes and their combination with cognitive functioning is still controversial in older people. The purpose of this study was to investigate the association between cognitive decline and hypertension, diabetes, and their combination in 70-year-old people based on a 3-year longitudinal analysis. Four hundred and fifty-four people aged 70 (±1) years who participated in the Japanese longitudinal cohort study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) were recruited randomly from a general population and were monitored for 3 years...
February 23, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28229224/factors-affecting-survival-of-patients-in-the-acute-phase-of-upper-cervical-spine-injuries
#4
Tomonori Morita, Tsuneo Takebayashi, Hideto Irifune, Hirofumi Ohnishi, Suguru Hirayama, Toshihiko Yamashita
INTRODUCTION: In recent years, on the one hand, the mortality rates of upper cervical spine injuries, such as odontoid fractures, were suggested to be not so high, but on the other hand reported to be significantly high. Furthermore, it has not been well documented the relationship between survival rates and various clinical features in those patients during the acute phase of injury because of few reports. This study aimed to evaluate survival rates and acute-phase clinical features of upper cervical spine injuries...
February 22, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28228715/central-nervous-insulin-administration-before-nocturnal-sleep-decreases-breakfast-intake-in-healthy-young-and-elderly-subjects
#5
João C P Santiago, Manfred Hallschmid
Peripheral insulin acts on the brain to regulate metabolic functions, in particular decreasing food intake and body weight. This concept has been supported by studies in humans relying on the intranasal route of administration, a method that permits the direct permeation of insulin into the CNS without substantial absorption into the blood stream. We investigated if intranasal insulin administration before nocturnal sleep, a period of reduced metabolic activity and largely absent external stimulation, affects food intake and energy turnover on the subsequent morning...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28228454/sex-differences-in-long-term-mortality-after-stroke-in-the-instruct-international-stroke-outcomes-study-a-meta-analysis-of-individual-participant-data
#6
Hoang T Phan, Christopher L Blizzard, Mathew J Reeves, Amanda G Thrift, Dominique Cadilhac, Jonathan Sturm, Emma Heeley, Petr Otahal, Vemmos Konstantinos, Craig Anderson, Priya Parmar, Rita Krishnamurthi, Suzanne Barker-Collo, Valery Feigin, Yannick Bejot, Norberto L Cabral, Antonio Carolei, Simona Sacco, Nicolas Chausson, Stephane Olindo, Peter Rothwell, Carolina Silva, Manuel Correia, Rui Magalhães, Peter Appelros, Janika Kõrv, Riina Vibo, Cesar Minelli, Seana Gall
BACKGROUND: Women are reported to have greater mortality after stroke than men, but the reasons are uncertain. We examined sex differences in mortality at 1 and 5 years after stroke and identified factors contributing to these differences. METHODS AND RESULTS: Individual participant data for incident strokes were obtained from 13 population-based incidence studies conducted in Europe, Australasia, South America, and the Caribbean between 1987 and 2013. Data on sociodemographics, stroke-related factors, prestroke health, and 1- and 5-year survival were obtained...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28226014/-pharmacotherapeutic-profile-and-factors-associated-with-polypharmacy-among-the-elderly-in-aiquara-bahia-brazil-2014
#7
Alessandra Santos Sales, Marta Gabriele Santos Sales, Cezar Augusto Casotti
Objective: to describe the drugs used and analyze the factors associated with polypharmacy in the elderly, in Aiquara, Bahia, Brazil. Methods: this is a census cross-sectional study, conducted in February 2014, through an interview using standardized form. Results: among the 272 elderly respondents, 53.3% used only prescribed medication and 31.6% used at least one medication not prescribed; the prevalence of polypharmacy was 29.0%; cardiovascular drugs were the most used in polypharmacy (n=390; 37...
January 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28225718/frailty-and-circulating-markers-of-inflammation-in-hiv-and-hiv-men-in-the-multicenter-aids-cohort-study
#8
Joseph B Margolick, Jay H Bream, Otoniel Martínez-Maza, Joe Lopez, Xiuhong Li, John P Phair, Susan L Koletar, Lisa P Jacobson
BACKGROUND: Frailty is associated with immune activation and inflammation in the elderly general population, but whether this is true in the younger HIV-infected (HIV+) population is not known. METHODS: We analyzed 24 serologic biomarkers of monocyte, T-cell, or B-cell activation in HIV- (n = 207) and HIV+ (n = 714; 75% virologically suppressed) men who have sex with men in the Multicenter AIDS Cohort Study (MACS) and were classified as frail or nonfrail according to expression or nonexpression of the frailty phenotype at 2 consecutive study visits...
April 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28225145/significant-variations-in-the-seroprevalence-of-c6-elisa-antibodies-in-a-highly-endemic-area-for-lyme-borreliosis-evaluation-of-age-sex-and-seasonal-differences
#9
Marcus Johansson, Lena Manfredsson, Annika Wistedt, Lena Serrander, Ivar Tjernberg
The purpose of this study was to assess the seroprevalence of C6 ELISA antibodies in healthy blood donors in Kalmar County, Sweden, in relation to age, sex and time of year (peak season vs off season). In addition, we wanted to assess serological status over time in a group of C6 ELISA seropositive blood donors. Sera were collected from 273 (131 women, 142 men) blood donors in autumn 2011 and 300 (144 women, 156 men) in winter 2014. All sera were analysed in the C6 ELISA and the results were interpreted according to the manufacturer's instructions...
February 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28224962/-gambling-in-elderly-patients
#10
Morgane Guillou Landreat, Jean-Yves Le Reste, Catherine Théréné-Mouden, Julie Caillon, Jennyfer Cholet, Marie Grall Bronnec
Behavioural addictions concern behaviour which generate pleasure (shopping, gambling, sex, etc.). Pathological gambling is the most common behavioural addiction in elderly people. It can be severely harmful causing psychological, financial and family problems and increasing the risk of suicide. Gambling addiction is underestimated in the elderly. Psychological, social and family support is important whatever the age, with treatment aiming to improve the person's quality of life, help them regain control of their gambling or stop altogether...
January 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28220234/prevalence-of-dieting-and-fear-of-weight-gain-across-ages-a-community-sample-from-adolescents-to-the-elderly
#11
Margarita C T Slof-Op 't Landt, Eric F van Furth, Catharina E M van Beijsterveldt, Meike Bartels, Gonneke Willemsen, Eco J de Geus, Lannie Ligthart, Dorret I Boomsma
OBJECTIVES: The current study aimed to define the prevalence of dieting and fear of weight gain among men and women across the entire lifespan and identify factors associated with them. METHODS: Data were available for 31,636 participants (60.2% women; age 13-98 years) from the Netherlands Twin Register. Dieting and fear of weight gain were described by age and sex. Associations with BMI, exercise behavior, urbanization and educational attainment were examined by regression analyses in 19,294 participants...
February 20, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28219916/comparison-of-carotid-femoral-and-brachial-ankle-pulse-wave-velocity-in-association-with-target-organ-damage-in-the-community-dwelling-elderly-chinese-the-northern-shanghai-study
#12
Yuyan Lu, Mengyun Zhu, Bin Bai, Chen Chi, Shikai Yu, Jiadela Teliewubai, Henry Xu, Kai Wang, Jing Xiong, Yiwu Zhou, Hongwei Ji, Ximin Fan, Xuejing Yu, Jue Li, Jacques Blacher, Yi Zhang, Yawei Xu
BACKGROUND: Carotid-femoral pulse-wave velocity (cf-PWV) and brachial-ankle PWV (ba-PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf-PWV and ba-PWV. METHODS AND RESULTS: A total of 1599 community-dwelling elderly subjects (age >65 years) in northern Shanghai were recruited from June 2014 to August 2015. Both cf-PWV and ba-PWV were measured using SphygmoCor and VP1000 systems, respectively...
February 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28219351/positive-bacterial-culture-in-conjunctival-sac-before-cataract-surgery-with-night-stay-is-related-to-diabetes-mellitus
#13
Tetsuhiro Kawata, Toshihiko Matsuo
BACKGROUND: The aim of this study is to elucidate background clinical factors in patients with positive bacterial culture for the conjunctival sac before cataract surgery in Japan. METHODS: Retrospective review was made on medical records of 576 consecutive patients who underwent conjunctival sac culture before cataract surgery with night stay at a hospital in 2 years from January 2013 to December 2014. In the patients with sequential bilateral surgeries, the data were chosen for bacterial culture in the eye which had earlier surgery...
February 20, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28212690/insomnia-and-multimorbidity-in-the-community-elderly-in-china
#14
Yu-Mei Wang, Mei Song, Ran Wang, Le Shi, Jia He, Teng-Teng Fan, Wen-Hao Chen, Lan Wang, Lu-Lu Yu, Yuan-Yuan Gao, Xiao-Chuang Zhao, Na Li, Ying Han, Mei-Yan Liu, Lin Lu, Xue-Yi Wang
STUDY OBJECTIVES: To examine the comorbidity between insomnia and medical problems. METHODS: This cross-sectional study was conducted in community adults, aged 60 y or older, who resided in one of four major cities in northern China. Sociodemographic and clinical data were collected simultaneously. A total of 3,176 elderly adults (1,292 male, 70.2 ± 6.8 y; 1,884 female, 68.8 ± 6.7 y) were interviewed. RESULTS: The prevalence of specific medical conditions in both people with insomnia and people without insomnia was detected...
February 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28207574/laparoscopic-and-open-surgical-treatment-in-gastroduodenal-perforations-our-experience
#15
Rita Laforgia, Giovanni Balducci, Giuseppe Carbotta, Antonio Prestera, Maria Grazia Sederino, Giulia Casamassima, Marina Minafra, Pierluca Sallustio, Nicola Palasciano
INTRODUCTION: Peptic ulcer perforation (PPU) is a common surgical emergency and the mortality rate ranges 10% to 40%, especially in elderly patients. Laparoscopic repair achieved encouraging results. MATERIALS AND METHODS: We enrolled patients performing surgical repair for PPU from January 2007 to December 2015 in our surgical unit. The aim of this retrospective observational study was to compare the results of PPU laparoscopic repair with open technique. The following characteristics of patients were evaluated: age, sex and American Society of Anesthesiologists classification...
February 15, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28203247/elevated-serum-uric-acid-levels-are-related-to-cognitive-deterioration-in-an-elderly-japanese-population
#16
Kazushi Suzuki, Daisuke Koide, Kurumi Fujii, Tsutomu Yamazaki, Shoji Tsuji, Atsushi Iwata
AIMS: The association between serum uric acid (UA) levels and cognitive function is controversial since UA can be a risk factor for cerebral ischemia as well as acting as a neuroprotective antioxidant. METHODS: We conducted a cross-sectional analysis of 228 elderly participants and examined neuropsychological test results, clinical data as well as brain magnetic resonance imaging data. PATIENTS: Overall, 64 participants were diagnosed with cognitive deterioration...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28202054/increase-of-urinary-malondialdehyde-level-by-bisphenol-a-exposure-a-longitudinal-panel-study
#17
Jin Hee Kim, Yun-Chul Hong
BACKGROUND: To verify oxidative stress as a possible mechanism that establishes a relationship between exposure to bisphenol A (BPA) and adverse health outcomes in the elderly Korean population, we evaluated the relation between visit-to-visit variations in urinary BPA and oxidative stress biomarker. METHODS: To assess the relation between BPA and urinary malondialdehyde (MDA) as an oxidative stress biomarker, we used a mixed effect model after controlling for age, sex, BMI, drinking status, exercise, urinary cotinine level, PM10 on lag day 2, and mean temperature and dew point on the day...
February 15, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28201940/food-insecurity-and-its-association-with-school-absenteeism-among-rural-school-adolescents-in-jimma-zone-ethiopia
#18
Dessalegn Tamiru, Yabsira Melaku, Tefera Belachew
Studies showed that poor health and nutrition among school adolescents are major barriers to educational access and achievements in low-income countries. This school-based study was aimed to assess the association of school absenteeism and food insecurity among rural school adolescents from grades 5 to 8 in Jimma zone, Ethiopia. Regression analyses were used to see the strength of association between dependent and independent variables using odds ratio and 95% confidence intervals. Multivariable logistic regression analysis was used to identify the predictor of school absenteeism...
February 1, 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28198967/fall-and-its-association-with-the-frailty-syndrome-in-the-elderly-systematic-review-with-meta-analysis
#19
Jack Roberto Silva Fhon, Rosalina Aparecida Partezani Rodrigues, Wilmer Fuentes Neira, Violeta Magdalena Rojas Huayta, Maria Lucia do Carmo Cruz Robazzi
OBJECTIVE: To analyze the prevalence of falls and frailty syndrome and the association between these two syndromes in the elderly population. METHOD: Systematic review, without restriction of dates, in English, Portuguese and Spanish languages, in the databases PubMed, CINAHL, LILACS and in the SciElo virtual library. The association between both variables was extracted from the studies (Odds Ratio and 95% Confidence Intervals). RESULTS: The review included 19 studies published between 2001 and 2015...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28196196/identification-of-transthyretin-cardiac-amyloidosis-using-serum-retinol-binding-protein-4-and-a-clinical-prediction-model
#20
Marios Arvanitis, Clarissa M Koch, Gloria G Chan, Celia Torres-Arancivia, Michael P LaValley, Daniel R Jacobson, John L Berk, Lawreen H Connors, Frederick L Ruberg
Importance: Transthyretin cardiac amyloidosis (ATTR) is an underrecognized cause of heart failure (HF) in older individuals, owing in part to difficulty in diagnosis. ATTR can result from substitution of valine for isoleucine at codon 122 of the transthyretin (TTR) gene (V122I), present in 3.43% of African American individuals. Objective: To examine whether serum retinol-binding protein 4 (RBP4), an endogenous TTR ligand, could be used as a diagnostic test for ATTR V122I amyloidosis...
February 8, 2017: JAMA Cardiology
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