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https://www.readbyqxmd.com/read/28549308/climate-and-the-eye-case-crossover-analysis-of-retinal-detachment-after-exposure-to-ambient-heat
#1
Nathalie Auger, Marc-André Rhéaume, Marianne Bilodeau-Bertrand, Tina Tang, Tom Kosatsky
BACKGROUND: Retinal detachment is an important cause of visual loss, but the association with outdoor heat exposure has not been studied. Our objective was to determine the relationship between acute exposure to high outdoor temperature and risk of retinal detachment. MATERIALS AND METHODS: We analysed 14,302 individuals with inpatient procedures for retinal detachment from April through September between 2006 and 2013 in the province of Quebec, Canada. Using a time-stratified case-crossover study design, we examined the association of retinal detachment with outdoor summer temperature the preceding week...
May 23, 2017: Environmental Research
https://www.readbyqxmd.com/read/28548975/factor-vii-activating-protease-sex-related-association-with-coronary-artery-calcification
#2
Ramshanker Ramanathan, Jørgen B Gram, Niels Peter R Sand, Bjarne L Nørgaard, Axel C P Diederichsen, Frank Vitzthum, Herbert Schwarz, Johannes J Sidelmann
: Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured...
May 25, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28548875/overweight-obesity-and-height-as-risk-factors-for-meningioma-glioma-pituitary-adenoma-and-nerve-sheath-tumor-a-large-population-based-prospective-cohort-study
#3
Markus K H Wiedmann, Cathrine Brunborg, Antonio Di Ieva, Kristina Lindemann, Tom B Johannesen, Lars Vatten, Eirik Helseth, John A Zwart
BACKGROUND: In 2016, the International Agency for Research on Cancer (IARC) has announced that avoiding body fatness (i.e. overweight and obesity) contributes to prevent meningioma occurrence, but considered the available evidence for glioma inadequate. The association of body fatness with other CNS tumor subgroups is largely unknown. OBJECTIVES: To assess whether body fatness or body height are associated with risk for meningioma, glioma, pituitary adenoma (PA) or nerve sheath tumor (NST) in a large population-based Norwegian cohort...
May 26, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28548584/the-sex-disparity-in-risky-driving-a-survey-of-colombian-young-drivers
#4
Oscar Oviedo-Trespalacios, Bridie Scott-Parker
OBJECTIVE: The overrepresentation of young drivers in poor road safety outcomes has long been recognised as a global road safety issue. In addition, the overrepresentation of males in crash statistics has also been recognised as a pervasive young driver problem. Whilst progress in road safety evidenced as a stabilisation and/or reduction in poor road safety outcomes has been made in developed nations, less-developed nations contribute the greatest road safety trauma, and developing nations such as Colombia continue to experience increasing trends in fatality rates...
May 26, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28548453/mortality-in-type-1-diabetes-diagnosed-in-childhood-in-northern-ireland-during-1989-2012-a-population-based-cohort-study
#5
Eileen Morgan, Catherine R Black, Noina Abid, Christopher R Cardwell, David R McCance, Christopher C Patterson
OBJECTIVE: To investigate long-term mortality rates and causes of death in individuals diagnosed with type 1 diabetes before the age of 15 years during the period 1989-2012 or known to paediatric diabetes teams in 1989, in Northern Ireland. METHODS: A cohort of 3129 patients from the Northern Ireland Childhood Diabetes Register was linked to death registrations and underlying causes, coded according to ICD-9 or ICD-10. Standardized mortality ratios (SMRs) were calculated as the ratio of observed to expected deaths by sex, attained age, time since diagnosis, calendar period, and cause of death...
May 26, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28548290/metacarpal-growth-during-adolescence-in-a-longitudinal-south-african-cohort
#6
A Magan, L H Nyati, L K Micklesfield, S A Norris, J M Pettifor
To monitor the drift of the periosteal and endocortical surfaces during metacarpal growth longitudinally, radiogrammetry was carried out on hand-wrist x-rays of 572 children from the Birth to Twenty Bone Health Cohort annually from ages 9-21 years. This is the largest collection of longitudinal x-rays in African children. The 2(nd) metacarpal bone length, bone width and medullary width were measured using digital vernier callipers on a total of 4730 x-rays. Superimposition by Translation and Rotation (SITAR) was used to obtain age at peak metacarpal length velocity (PLV)...
May 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28548250/evolution-of-deep-gray-matter-volume-across-the-human-lifespan
#7
Karl Narvacan, Sarah Treit, Richard Camicioli, Wayne Martin, Christian Beaulieu
Magnetic resonance imaging of subcortical gray matter structures, which mediate behavior, cognition and the pathophysiology of several diseases, is crucial for establishing typical maturation patterns across the human lifespan. This single site study examines T1-weighted MPRAGE images of 3 healthy cohorts: (i) a cross-sectional cohort of 406 subjects aged 5-83 years; (ii) a longitudinal neurodevelopment cohort of 84 subjects scanned twice approximately 4 years apart, aged 5-27 years at first scan; and (iii) a longitudinal aging cohort of 55 subjects scanned twice approximately 3 years apart, aged 46-83 years at first scan...
May 26, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28548190/-clinical-features-of-major-depressive-disorders-treated-in-secondary-health-care-facilities-in-chile
#8
Lilian Salvo, Sandra Saldivia, Carlos Parra, Román Rodríguez, Manuel Cifuentes, Paola Acevedo, Marcela Díaz, Mitza Ormazabal, Ivonne Guerra, Nicol Navarrete, Verónica Bravo, Andrea Castro
BACKGROUND: Depression is considered the second leading cause of disability worldwide. AIM: To describe the clinical characteristics and the evolution of major depressive disorder (MDD) in secondary care. To evaluate the association between socio-demographic and clinic variables with the first or recurrent major depressive events (MDE). MATERIAL AND METHODS: Clinical features, treatment, remission and duration of MDE were evaluated during a follow up lasting 12 months in 112 participants aged 44 ± 15 years (79% women)...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28548032/impact-of-age-sex-socioeconomic-status-and-physical-activity-on-associated-movements-and-motor-speed-in-preschool-children
#9
Tanja H Kakebeeke, Annina E Zysset, Nadine Messerli-Bürgy, Aziz Chaouch, Kerstin Stülb, Claudia S Leeger-Aschmann, Einat A Schmutz, Amar Arhab, Valentin Rousson, Susi Kriemler, Simone Munsch, Jardena J Puder, Oskar G Jenni
INTRODUCTION: Young children generally show contralateral associated movements (CAMs) when they are making an effort to perform a unimanual task. CAM and motor speed are two relevant aspects of motor proficiency in young children. These CAMs decrease over age, while motor speed increases. As both CAM and motor speed are associated with age, we were interested in whether these two parameters are also linked with each other. METHOD: In this study, three manual dexterity tasks with the dominant and nondominant hands (pegboard, repetitive hand, and repetitive finger tasks) were used to investigate the effect of covariates (age, sex, socioeconomic status, total physical activity) on both motor speed and CAMs in preschool children...
May 26, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28547776/anatomical-relationship-of-maxillary-posterior-teeth-with-the-sinus-floor-and-buccal-cortex
#10
J K Jang, S W Kwak, J H Ha, H C Kim
This study aimed to evaluate the possibility of root fenestration or oroantral communication by evaluating the distance from root apex to the sinus floor and buccal cortex in maxillary posterior teeth by using cone-beam computed tomography (CBCT) images. The study included 2,182 roots of the maxillary posterior teeth from 219 patients after reviewing CBCT images of 462 patients according to the location of roots by two endodontists. The distances from each root apex to the maxillary sinus floor and buccal and palatal cortices were evaluated according to sex and age, and the mean values were compared by one-way analysis of variance and Mann-Whitney U test...
May 26, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28547774/population-pharmacokinetics-pharmacodynamics-and-exploratory-exposure-response-analyses-of-apixaban-in-subjects-treated-for-venous-thromboembolism
#11
W Byon, K Sweeney, C Frost, R A Boyd
Apixaban is approved for treatment of venous thromboembolism (VTE) and prevention of recurrence. Population pharmacokinetics, pharmacokinetics-pharmacodynamics (anti-FXa activity), and exposure-response (binary bleeding and thromboembolic endpoints) of apixaban in VTE treatment subjects were characterized using data from phase I-III studies. Apixaban pharmacokinetics were adequately characterized by a two-compartment model with first-order absorption and elimination. Age, sex, and Asian race had less than 25% impact on exposure, while subjects with severe renal impairment were predicted to have 56% higher exposure than the reference subject (60-year-old non-Asian male weighing 85 kg with creatinine clearance of 100 mL/min)...
May 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28547588/neurocognition-in-individuals-with-incidentally-identified-meningioma
#12
Alissa M Butts, Stephen Weigand, Paul D Brown, Ronald C Petersen, Clifford R Jack, Mary M Machulda, Jane H Cerhan
Meningiomas are primary intracranial tumors that are often asymptomatic. To our knowledge, no study has attempted to describe neurocognitive function in patients with incidentally-discovered meningioma. We utilized the Mayo Clinic Study of Aging (MCSA), which is a population-based sample of Olmsted County, Minnesota residents that includes neuropsychological testing and brain MRI approximately every 15 months. Using a text search of radiologists' notes of 2402 MCSA individuals (mean age 77 years, scanned between 2004 and 2014) we identified 48 eligible subjects (2%) who had at least one meningioma...
May 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28547345/where-are-adults-active-an-examination-of-physical-activity-locations-using-gps-in-five-us-cities
#13
Katelyn M Holliday, Annie Green Howard, Michael Emch, Daniel A Rodríguez, Wayne D Rosamond, Kelly R Evenson
Increasing physical activity (PA) at the population level requires appropriately targeting intervention development. Identifying the locations in which participants with various sociodemographic, body weight, and geographic characteristics tend to engage in varying intensities of PA as well as locations these populations underutilize for PA may facilitate this process. A visual location-coding protocol was developed and implemented in Google Fusion Tables and Maps using data from participants (N = 223, age 18-85) in five states...
May 25, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28547208/pulse-wave-velocity-and-augmentation-index-are-not-independently-associated-with-carotid-atherosclerosis-in-patients-with-rheumatoid-arthritis
#14
M Robustillo-Villarino, J J Alegre-Sancho, E Rodilla-Sala, A Corrales, J Llorca, M A Gonzalez-Gay, P H Dessein
Arterial stiffness can enhance cardiovascular risk by increasing atherogenesis or adverse hemodynamic effects. We examined whether the arterial stiffness markers of aortic pulse wave velocity (PWV) and the augmentation index (AIx) are independently associated with carotid artery intima-media thickness (IMT) and plaque in patients with rheumatoid arthritis (RA). PWV and AIx were determined by brachial oscillometry using the Mobil-O-Graph® system and carotid IMT and plaque by ultrasound in 194 consecutive RA patients without established cardiovascular disease, chronic kidney disease, and diabetes at disease onset...
May 25, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28547132/retinal-oxygen-extraction-in-individuals-with-type-1-diabetes-with-no-or-mild-diabetic-retinopathy
#15
Klemens Fondi, Piotr A Wozniak, Kinga Howorka, Ahmed M Bata, Gerold C Aschinger, Alina Popa-Cherecheanu, Katarzyna J Witkowska, Anton Hommer, Doreen Schmidl, René M Werkmeister, Gerhard Garhöfer, Leopold Schmetterer
AIMS/HYPOTHESIS: The aim of this study was to compare retinal oxygen extraction in individuals with diabetes with no or mild non-proliferative diabetic retinopathy and healthy age- and sex-matched volunteers. METHODS: A total of 24 participants with type 1 diabetes and 24 healthy age- and sex-matched volunteers were included in this cross-sectional study. Retinal oxygen extraction was measured by combining total retinal blood flow measurements using a custom-built bi-directional Doppler optical coherence tomography system with measurements of oxygen saturation using spectroscopic reflectometry...
May 25, 2017: Diabetologia
https://www.readbyqxmd.com/read/28547001/new-mathematical-model-for-the-surface-area-of-the-left-ventricle-by-the-truncated-prolate-spheroid
#16
José Sérgio Domingues, Marcos de Paula Vale, Carlos Barreira Martinez
The main aim of this study was the formula application of the superficial area of a truncated prolate spheroid (TPS) in Cartesian coordinates in obtaining a cardiac parameter that is not so much discussed in literature, related to the left ventricle (LV) surface area of the human heart, by age and sex. First we obtain a formula for the area of a TPS. Then a simple mathematical model of association of the axes measures of a TPS with the axes of the LV is built. Finally real values of the average dimensions of the humans LV are used to measure surface areas approximations of this heart chamber...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28546936/clinical-characteristics-of-sibling-patients-with-comitant-strabismus
#17
Haeng Jin Lee, Seong-Joon Kim, Young Suk Yu
AIM: To investigate the clinical characteristics of sibling patients with comitant strabismus. METHODS: Sibling patients who were diagnosed with comitant strabismus from January 2005 to December 2014 were retrospectively reviewed. Factors including age, sex, types of strabismus, refractive errors, angle of deviation, and coexistence of other strabismus were analyzed. RESULTS: A total of 62 patients (31 pairs of siblings) were included. Of these, 26 pairs had intermittent exotropia, 3 had accommodative esotropia, and 2 had infantile esotropia...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546925/comparison-of-corneal-biomechanics-in-sj%C3%A3-gren-s-syndrome-and-non-sj%C3%A3-gren-s-syndrome-dry-eyes-by-scheimpflug-based-device
#18
Qin Long, Jing-Yi Wang, Dong Xu, Ying Li
AIM: To compare the corneal biomechanics of Sjögren's syndrome (SS) and non-SS dry eyes with Corneal Visualization Scheimpflug Technology (CorVis ST). METHODS: Corneal biomechanics and tear film parameters, namely the Schirmer I test value, tear film break-up time (TBUT) and corneal staining score (CSS) were detected in 34 eyes of 34 dry eye patients with SS (SSDE group) and 34 dry eye subjects without SS (NSSDE group) using CorVis ST. The differences of the above parameters between the two groups were examined, and the relationship between corneal biomechanics and tear film parameters were observed...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546861/association-between-recurrence-of-acute-kidney-injury-and-mortality-in-intensive-care-unit-patients-with-severe-sepsis
#19
Emilio Rodrigo, Borja Suberviola, Miguel Santibáñez, Lara Belmar, Álvaro Castellanos, Milagros Heras, Juan Carlos Rodríguez-Borregán, Angel Luis Martín de Francisco, Claudio Ronco
BACKGROUND: Acute kidney injury (AKI) occurs in more than half critically ill patients admitted in intensive care units (ICU) and increases the mortality risk. The main cause of AKI in ICU is sepsis. AKI severity and other related variables such as recurrence of AKI episodes may influence mortality risk. While AKI recurrence after hospital discharge has been recently related to an increased risk of mortality, little is known about the rate and consequences of AKI recurrence during the ICU stay...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28546848/estimation-of-maximal-oxygen-consumption-and-heart-rate-recovery-using-the-tecumseh-sub-maximal-step-test-and-their-relationship-to-cardiovascular-risk-factors
#20
Alun D Hughes, Nish Chaturvedi
BACKGROUND: Maximum aerobic capacity (VO2max) is associated with lower cardiovascular and total mortality. Step tests can be used to provide an estimate of (VO2max) in epidemiological or home-based studies. We compared different methods of estimation of VO2max and heart rate recovery and evaluated the relationship of these estimates with cardiovascular risk factors. METHODS: Data were analysed from 2286 participants in the Tecumseh Community Health Study (>16y and <70y) who performed a step test...
June 2017: Artery Research
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