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https://www.readbyqxmd.com/read/28929029/association-of-rs1801157-single-nucleotide-polymorphism-of-cxcl12-gene-in-breast-cancer-in-pakistan-and-in-silico-expression-analysis-of-cxcl12-cxcr4-associated-biological-regulatory-network
#1
Samra Khalid, Rumeza Hanif
BACKGROUND: C-X-C chemokine ligand 12 (CXCL12) has important implications in breast cancer (BC) pathogenesis. It is selectively expressed on B and T lymphocytes and is involved in hematopoiesis, thymocyte trafficking, stem cell motility, neovascularization, and tumorigenesis. The single nucleotide polymorphism (SNP) rs1801157 of CXCL12 gene has been found to be associated with higher risk of BC. METHODS: Our study focuses on the genotypic and allelic distribution of SNP (rs1801157; G/A) in Pakistani population as well as its association with the clinico-pathological features...
2017: PeerJ
https://www.readbyqxmd.com/read/28926376/seeking-to-close-the-loopholes-in-transplant-tourism-and-organ-trafficking
#2
Jeremy R Chapman
No abstract text is available yet for this article.
September 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28924207/novel-ecto-tagged-integrins-reveal-their-trafficking-in-live-cells
#3
Clotilde Huet-Calderwood, Felix Rivera-Molina, Daniel V Iwamoto, Emil B Kromann, Derek Toomre, David A Calderwood
Integrins are abundant heterodimeric cell-surface adhesion receptors essential in multicellular organisms. Integrin function is dynamically modulated by endo-exocytic trafficking, however, major mysteries remain about where, when, and how this occurs in living cells. To address this, here we report the generation of functional recombinant β1 integrins with traceable tags inserted in an extracellular loop. We demonstrate that these 'ecto-tagged' integrins are cell-surface expressed, localize to adhesions, exhibit normal integrin activation, and restore adhesion in β1 integrin knockout fibroblasts...
September 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28923791/gja1-20k-arranges-actin-to-guide-cx43-delivery-to-cardiac-intercalated-discs
#4
Wassim A Basheer, Shaohua Xiao, Irina Epifantseva, Ying Fu, Andre G Kleber, TingTing Hong, Robin M Shaw
Rationale: Delivery of connexin 43 (Cx43) to the intercalated disc is a continuous and rapid process critical for intercellular coupling. By a pathway of targeted delivery involving microtubule highways, vesicles of Cx43 hemichannels are efficiently trafficked to adherens junctions at intercalated discs. It has also been identified that actin provides rest stops for Cx43 forward trafficking, and that Cx43 has a 20kDa internally translated small C-terminus isoform (GJA1-20k) which is required for full-length Cx43 trafficking, but by an unknown mechanism...
September 18, 2017: Circulation Research
https://www.readbyqxmd.com/read/28922401/rab11-family-expression-in-the-human-placenta-localization-at-the-maternal-fetal-interface
#5
Elizabeth S Taglauer, Patrycja A Artemiuk, Sara R Hanscom, Andrew J Lindsay, Danielle Wuebbolt, Fionnuala M Breathnach, Elizabeth C Tully, Amir R Khan, Mary W McCaffrey
Rab proteins are a family of small GTPases involved in a variety of cellular processes. The Rab11 subfamily in particular directs key steps of intracellular functions involving vesicle trafficking of the endosomal recycling pathway. This Rab subfamily works through a series of effector proteins including the Rab11-FIPs (Rab11 Family-Interacting Proteins). While the Rab11 subfamily has been well characterized at the cellular level, its function within human organ systems is still being explored. In an effort to further study these proteins, we conducted a preliminary investigation of a subgroup of endosomal Rab proteins in a range of human cell lines by Western blotting...
2017: PloS One
https://www.readbyqxmd.com/read/28915712/formation-function-and-exhaustion-of-notochordal-cytoplasmic-vacuoles-within-intervertebral-disc-current-understanding-and-speculation
#6
REVIEW
Feng Wang, Zeng-Xin Gao, Feng Cai, Arjun Sinkemani, Zhi-Yang Xie, Rui Shi, Ji-Nan Wei, Xiao-Tao Wu
Notochord nucleus pulposus cells are characteristic of containing abundant and giant cytoplasmic vacuoles. This review explores the embryonic formation, biological function, and postnatal exhaustion of notochord vacuoles, aiming to characterize the signal network transforming the vacuolated nucleus pulposus cells into the vacuole-less chondrocytic cells. Embryonically, the cytoplasmic vacuoles within vertebrate notochord originate from an evolutionarily conserved vacuolation process during neurulation, which may continue to provide mechanical and signal support in constructing a mammalian intervertebral disc...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913786/the-lipid-droplet-a-conserved-cellular-organelle
#7
REVIEW
Congyan Zhang, Pingsheng Liu
The lipid droplet (LD) is a unique multi-functional organelle that contains a neutral lipid core covered with a phospholipid monolayer membrane. The LDs have been found in almost all organisms from bacteria to humans with similar shape. Several conserved functions of LDs have been revealed by recent studies, including lipid metabolism and trafficking, as well as nucleic acid binding and protection. We summarized these findings and proposed a hypothesis that the LD is a conserved organelle.
September 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28900914/stim-trp-pathways-and-microdomain-organization-contribution-of-trpc1-in-store-operated-ca-2-entry-impact-on-ca-2-signaling-and-cell-function
#8
Hwei Ling Ong, Indu S Ambudkar
Store-operated calcium entry (SOCE) is a ubiquitous Ca(2+) entry pathway that is activated in response to depletion of ER-Ca(2+) stores and critically controls the regulation of physiological functions in a wide variety of cell types. The transient receptor potential canonical (TRPC) channels (TRPCs 1-7), which are activated by stimuli leading to PIP2 hydrolysis, were first identified as molecular components of SOCE channels. While TRPC1 was associated with SOCE and regulation of function in several cell types, none of the TRPC members displayed I CRAC, the store-operated current identified in lymphocytes and mast cells...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28900595/low-uptake-of-silica-nanoparticles-in-caco-2-intestinal-epithelial-barriers
#9
Dong Ye, Mattia Bramini, Delyan R Hristov, Sha Wan, Anna Salvati, Christoffer Åberg, Kenneth A Dawson
Cellular barriers, such as the skin, the lung epithelium or the intestinal epithelium, constitute one of the first obstacles facing nanomedicines or other nanoparticles entering organisms. It is thus important to assess the capacity of nanoparticles to enter and transport across such barriers. In this work, Caco-2 intestinal epithelial cells were used as a well-established model for the intestinal barrier, and the uptake, trafficking and translocation of model silica nanoparticles of different sizes were investigated using a combination of imaging, flow cytometry and transport studies...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28892507/extreme-genome-diversity-in-the-hyper-prevalent-parasitic-eukaryote-blastocystis
#10
Eleni Gentekaki, Bruce A Curtis, Courtney W Stairs, Vladimír Klimeš, Marek Eliáš, Dayana E Salas-Leiva, Emily K Herman, Laura Eme, Maria C Arias, Bernard Henrissat, Frédérique Hilliou, Mary J Klute, Hiroshi Suga, Shehre-Banoo Malik, Arthur W Pightling, Martin Kolisko, Richard A Rachubinski, Alexander Schlacht, Darren M Soanes, Anastasios D Tsaousis, John M Archibald, Steven G Ball, Joel B Dacks, C Graham Clark, Mark van der Giezen, Andrew J Roger
Blastocystis is the most prevalent eukaryotic microbe colonizing the human gut, infecting approximately 1 billion individuals worldwide. Although Blastocystis has been linked to intestinal disorders, its pathogenicity remains controversial because most carriers are asymptomatic. Here, the genome sequence of Blastocystis subtype (ST) 1 is presented and compared to previously published sequences for ST4 and ST7. Despite a conserved core of genes, there is unexpected diversity between these STs in terms of their genome sizes, guanine-cytosine (GC) content, intron numbers, and gene content...
September 2017: PLoS Biology
https://www.readbyqxmd.com/read/28891394/the-role-of-chemokines-in-thyroid-carcinoma
#11
Sharinie Yapa, Omar Mulla, Victoria Green, James England, John Greenman
Global incidence of thyroid cancer is increasing and metastatic spread to lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process involving invasion, angiogenesis, cell trafficking, extravasation, organ specific homing and growth. A key aspect in this process involves a multitude of interactions between chemokines and their receptors. Chemokines are a group of small proteins, which act to elicit normal physiological and immune responses principally through recruitment of specific cell populations to site of infection or malignancy...
September 11, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28887593/v-snare-function-in-chromaffin-cells
#12
REVIEW
Madhurima Dhara, Ralf Mohrmann, Dieter Bruns
Vesicle fusion is elementary for intracellular trafficking and release of signal molecules, thus providing the basis for diverse forms of intercellular communication like hormonal regulation or synaptic transmission. A detailed characterization of the mechanisms underlying exocytosis is key to understand how the nervous system integrates information and generates appropriate responses to stimuli. The machinery for vesicular release employs common molecular players in different model systems including neuronal and neuroendocrine cells, in particular members of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) protein family, Sec1/Munc18-like proteins, and other accessory factors...
September 8, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28882895/peptide-array-based-screening-reveals-a-large-number-of-proteins-interacting-with-the-ankyrin-repeat-domain-of-the-zdhhc17-s-acyltransferase
#13
Kimon Lemonidis, Ruth MacLeod, George S Baillie, Luke H Chamberlain
zDHHC S-acyl-transferases are enzymes catalyzing protein S-acylation, a common post-translational modification on proteins frequently affecting their membrane targeting and trafficking. The ankyrin-repeat (AR) domain of zDHHC17 (HIP14) and zDHHC13 (HIP14L) S-acyltransferases, which is involved in both substrate recruitment and S-acylation-independent functions, was recently shown to bind at least six proteins, by specific recognition of a consensus sequence in them. To further refine the rules governing binding to the AR of zDHHC17, we employed peptide arrays based on zDHHC AR-binding motif (zDABM) sequences of synaptosomal-associated protein 25 (SNAP25) and cysteine string protein alpha (CSPα)...
September 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28879522/cell-non-autonomous-upr-er-signaling
#14
Soudabeh Imanikia, Ming Sheng, Rebecca C Taylor
The UPR(ER) is an important regulator of secretory pathway homeostasis, and plays roles in many physiological processes. Its broad range of targets and ability to modulate secretion and membrane trafficking make it perfectly positioned to influence intercellular communication, enabling the UPR(ER) to coordinate physiological processes between cells and tissues. Recent evidence suggests that the activation of the UPR(ER) can itself be communicated between cells. This cell non-autonomous route to UPR(ER) activation occurs in multiple species, and enables organism-wide responses to stress that involve processes as diverse as immunity, metabolism, aging and reproduction...
September 7, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28876222/co-expression-of-xenopsin-and-rhabdomeric-opsin-in-photoreceptors-bearing-microvilli-and-cilia
#15
Oliver Vöcking, Ioannis Kourtesis, Sharat Chandra Tumu, Harald Hausen
Ciliary and rhabdomeric opsins are employed by cells differing fundamentally in structure and molecular physiology, such as ciliary vertebrate rods and cones and protostome microvillar eye photoreceptors. We report unprecedented cellular co-expression of rhabdomeric opsin and a visual pigment of the recently described xenopsins in larval eyes of a mollusk. The photoreceptors bear both microvilli and cilia and express orthologs to transporters for microvillar and ciliary opsin trafficking. Highly conserved but distinct gene structures suggest that xenopsins and ciliary opsins are of independent origin, irrespective of their mutually exclusive distribution in animals...
September 6, 2017: ELife
https://www.readbyqxmd.com/read/28875299/-1-h-13-c-and-15-n-resonance-assignments-and-secondary-structures-of-cyclophilin-2-from-trichomonas-vaginalis
#16
Tesmine Martin, Yuan-Chao Lou, Sarita Aryal, Jung-Hsiang Tai, Chinpan Chen
Cyclophilins are peptidyl prolyl isomerases that play an important role in a wide variety of biological functions like protein folding and trafficking, intracellular and extracellular signaling pathways, nuclear translocation and in pre-mRNA splicing. Two cyclophilins have been identified in the parasitic organism Trichomonas vaginalis and were named as TvCyP1 and TvCyP2. The 2 enzymes have been found to interact with Myb transcription factors in the parasite which regulate the iron induced expression of ap65-1 gene leading to cytoadherence of the parasite to human vaginal epithelial cells to cause the disease trichomoniasis...
September 5, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28874659/internalized-tsh-receptors-en-route-to-the-tgn-induce-local-gs-protein-signaling-and-gene-transcription
#17
Amod Godbole, Sandra Lyga, Martin J Lohse, Davide Calebiro
A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH receptors traffic retrogradely to the trans-Golgi network (TGN) and activate endogenous Gs-proteins in the retromer-coated compartment that brings them to the TGN. Receptor internalization is associated with a late cAMP/protein kinase A (PKA) response at the Golgi/TGN...
September 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28874079/migration-agency-and-the-sex-industry-practitioners-perspectives-on-foreign-sex-workers-in-turkey
#18
Omur Kaya, Edna Erez
The article presents the political, economic, and sociocultural factors that make Turkey an attractive destination for foreign sex workers, and reviews trends in official statistics of arrested traffickers, rescued victims, and deportation of migrant illegal sex workers. In-depth interviews of 20 law enforcement and nongovernmental organizations staff members, who in the course of their work come into close contact with foreign sex workers, shed light on the statistics. The interview data provide insights into the structure of the Turkish sex market, the factors that bring foreign women to work in this market, and the impact of legal reforms on the circumstances of foreign sex workers...
September 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28871045/loss-of-arabidopsis-p24-function-affects-erd2-traffic-and-golgi-structure-and-activates-the-unfolded-protein-response
#19
Noelia Pastor-Cantizano, Cesar Bernat-Silvestre, María Jesús Marcote, Fernando Aniento
p24 proteins are key regulators of protein trafficking along the secretory pathway but very little is known about their functions in plants. A quadruple loss-of-function mutant affecting the p24 genes from the δ-1 subclass of the p24 delta subfamily (p24δ3δ4δ5δ6) showed alterations in the Golgi apparatus, suggesting that these p24 proteins play a role in the organization of the compartments of the early secretory pathway in Arabidopsis Loss of p24δ-1 proteins also induced the accumulation of the K/HDEL receptor ERD2 at the Golgi apparatus and increased secretion of the ER chaperone BiP, an HDEL ligand, probably due to an inhibition of COPI-dependent Golgi-to-ER transport of ERD2 and thus retrieval of K/HDEL ligands...
September 4, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28870639/migratory-properties-of-ex-vivo-expanded-regulatory-t-cells-influence-of-all-trans-retinoic-acid-and-rapamycin
#20
J L Beermann, C T Thiesler, U Dringenberg, C Alter, S Kuhs, S Velaga, S N Ukena, A Franzke
Adoptively transferred regulatory T-cells represent a promising therapeutic approach for tolerance induction in autoimmunity and transplantation medicine. However, a major hurdle for clinical application is the manufacturing of sufficient Treg cell numbers with respect to the low frequency of naturally occurring Tregs in the peripheral blood. Therefore, ex vivo large-scale expansion is mandatory for most of the clinical conditions. Besides the Treg cell number other parameters of the cell product are of high relevance for safe and efficient clinical Treg cell application like Treg cell purity, suppressive capacity and genetic stability of the Treg cell phenotype...
September 1, 2017: Transplant Immunology
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