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Sleep apnea and cardiovascular disease

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https://www.readbyqxmd.com/read/29458748/does-continuous-positive-airway-pressure-treatment-affect-autonomic-nervous-system-in-patients-with-severe-obstructive-sleep-apnea
#1
Francesca Izzi, Fabio Placidi, Claudio Liguori, Benedetta Lauretti, Girolama A Marfia, Antonio Pisani, Nicola B Mercuri, Camilla Rocchi
OBJECTIVE: This study is aimed at evaluating whether Continuous Positive Airway Pressure treatment (CPAP) may affect autonomic nervous system (ANS) in male patients with severe obstructive sleep apnea (OSAS). METHODS: We compared autonomic symptoms of de novo severe OSAS patients, OSAS patients on chronic CPAP treatment and healthy controls, using the Scales for Outcome in Parkinson disease-Autonomic (SCOPA-AUT) questionnaire. All groups underwent cardiovascular function tests including head-up tilt test (HUTT), Valsalva maneuver, deep breathing, hand grip and cold face tests...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29458700/sleep-health-and-predicted-cardiometabolic-risk-scores-in-employed-adults-from-two-industries
#2
Orfeu M Buxton, Soomi Lee, Miguel Marino, Chloe Beverly, David M Almeida, Lisa Berkman
STUDY OBJECTIVES: Sleep disorders and sleep deficiency can increase the risk for cardiovascular disease. Less is known about whether multiple positive attributes of sleep health known as the SATED (satisfaction, alertness, timing, efficiency, and duration) model, can decrease future cardiovascular disease risks. We examined whether and how a variety of indicators of sleep health predicted 10-year estimated cardiometabolic risk scores (CRS) among employed adults. METHODS: Workers in two industries-extended care (n = 1,275) and information technology (IT; n = 577)-reported on habitual sleep apnea symptoms and sleep sufficiency, and provided 1 week of actigraphy data including nighttime sleep duration, wake after sleep onset (WASO), sleep timing, and daytime napping...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29458695/comorbid-insomnia-with-obstructive-sleep-apnea-clinical-characteristics-and-risk-factors
#3
Yong Won Cho, Keun Tae Kim, Hye-Jin Moon, Valeriy R Korostyshevskiy, Gholam K Motamedi, Kwang Ik Yang
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) and chronic insomnia are two common sleep disorders and both are considered independent risk factors for heart disease. The aim of this study was to investigate the prevalence of comorbid insomnia with OSA and to compare its clinical characteristics with those of OSA without insomnia. METHODS: Patients who visited two tertiary university hospital sleep centers were screened. Those with a diagnosis of OSA using polysomnography were divided into two groups based on their scores on the Korean version of the Insomnia Severity Index (ISI-K): OSA with insomnia (OSA+I) (ISI-K score ≥ 15) and OSA without insomnia (OSA-I) (ISI-K score < 15)...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29458693/the-impact-of-continuous-positive-airway-pressure-on-circulating-igf-1-in-patients-with-obstructive-sleep-apnea
#4
Andreas Palm, Christian Berne, Helena Igelström, Pernilla Åsenlöf, Christer Janson, Eva Lindberg
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is a disease with metabolic and cardiovascular consequences and is associated with decreased serum concentrations of insulin-like growth factor-1 (IGF-1). The aim of this study was to investigate whether continuous positive airway pressure (CPAP) will increase serum IGF-1 concentration in patients with OSA. METHODS: Patients with moderate to severe OSA were recruited from a sleep clinic and serum IGF-1 was measured before initiation of CPAP and at follow-up after 4...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29453905/sleep-apnea-and-type-2-diabetes
#5
Isao Muraki, Hiroo Wada, Takeshi Tanigawa
The aim of this review is to clarify the association between obstructive sleep apnea (OSA) and type 2 diabetes, and discuss the therapeutic role of continuous positive airway pressure (CPAP) in type 2 diabetes. OSA patients are more likely than non-OSA populations to develop type 2 diabetes while more than half of patients with type 2 diabetes suffer from OSA. Similarly to the Western countries, in the East Asian population, the association between these two disorders has also been reported. CPAP is the primary treatment for OSA, but the effect of CPAP on comorbid diabetes has not been established...
February 17, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29450676/comorbid-obstructive-sleep-apnea-and-increased-risk-for-sickle-cell-disease-morbidity
#6
Tal Katz, Jeffrey Schatz, Carla W Roberts
PURPOSE: Sickle cell disease (SCD) imparts an increased risk for obstructive sleep apnea (OSA) in childhood. Studies of pediatric SCD have identified an increased risk for pain and neurologic complications with comorbid OSA. We determined the rate of a broad range of SCD-related medical complications to better characterize the spectrum of SCD complications related to OSA. METHODS: Retrospective chart review at a single hematology clinic identified 641 youth with SCD who received consistent screenings for OSA as part of routine hematological health maintenance visits over an 11-year period...
February 15, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29450504/association-of-adenotonsillectomy-with-blood-pressure-among-hypertensive-and-nonhypertensive-children-with-obstructive-sleep-apnea
#7
Cho-Hsueh Lee, Kun-Tai Kang, Shuenn-Nan Chiu, I-Sheng Chang, Wen-Chin Weng, Pei-Lin Lee, Wei-Chung Hsu
Importance: Hypertension in childhood may continue into adulthood and lead to adverse cardiovascular outcomes. Evidence suggests that adenotonsillectomy for childhood obstructive sleep apnea (OSA) may be associated with blood pressure (BP) improvement. However, how adenotonsillectomy is associated with BP in hypertensive and nonhypertensive children with OSA remains unclear. Objective: To investigate disparities in BP changes after adenotonsillectomy in hypertensive and nonhypertensive children with OSA...
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29446755/classification-methods-to-detect-sleep-apnea-in-adults-based-on-respiratory-and-oximetry-signals-a-systematic-review
#8
Md Bashir Uddin, Chin-Moi Chow, Steven W Su
Sleep apnea (SA), a common sleep disorder, can significantly decrease the quality of life, and is closely associated with major health risk such as cardiovascular disease, sudden death, depression, and hypertension. Normal diagnostic process of SA using polysomnography (PSG) is costly and time consuming. In addition, the accuracy of different classification methods to detect SA varies with the use of different physiological signals. If an effective, reliable, and accurate classification method is developed, then the diagnosis of SA and their associated treatment will be time-efficient and economical...
February 15, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29442057/inguinal-hernia-repair-in-day-surgery-the-role-of-mac-monitored-anesthesia-care-with-remifentanil
#9
P Palumbo, S Usai, C Amatucci, B Perotti, L Ruggeri, G Illuminati, G Tellan
BACKGROUND: The extension of indications for procedures in a Day Surgery (DS) setting has led to changes in the anesthetic and surgical treatment of Inguinal Hernias (IH). According to the recommendations of the European Hernia Society, the treatment of IH in DS units should be performed under Monitored Anesthesia Care (MAC). PATIENTS AND METHODS: 960 patients underwent IH repairs over a period of 24 months. The patients were randomly divided into two groups: R (remifentanil) and F (fentanyl); the group F was considered as a control group...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29425754/does-the-medical-comorbidity-profile-of-obstructive-sleep-apnea-patients-treated-with-maxillomandibular-advancement-differ-from-that-of-obstructive-sleep-apnea-patients-managed-nonsurgically
#10
Richard Ngo, Elaina Pullano, Zachary S Peacock, Edward T Lahey, Meredith August
PURPOSE: Obstructive sleep apnea (OSA) patients with retrognathia and measurable anatomic airway determinants may represent a subset of OSA patients and have distinct comorbidity profiles. Our aim was to compare the medical comorbidities of OSA patients managed surgically with maxillomandibular advancement with those of nonsurgical patients. PATIENTS AND METHODS: In this cross-sectional retrospective study, patients for both cohorts were identified through the Massachusetts General Hospital oral and maxillofacial surgery data registry and the Massachusetts General Hospital Research Patient Data Registry...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29424194/evaluation-of-endothelial-function-and-cardiovascular-risk-in-non-obese-patients-with-slight-degree-of-obstructive-sleep-apnea-syndrome
#11
Fiorella Devito, Annapaola Zito, Silvano Dragonieri, Pierluigi Carratù, Vitaliano N Quaranta, Francesco Vitale, Nicola Quaranta, Francesco Panza, Giancarlo Logroscino, Matteo Cameli, Onofrio Resta, Marco Matteo Ciccone
Recently, it has been clearly described an independent relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk, with underlying mechanisms also including endothelial dysfunction. We enrolled 32 consecutive non-obese patients (mean age of 39.5±11.5 years), of which 16 with mild OSAS and 16 snoring without OSAS. Mild OSAS is defined by an AHI index between 5 and 15. We have investigated if whether there was a relationship between mild OSAS, endothelial function and carotid intima-media thickness (C-IMT)...
December 5, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29424037/severity-of-osas-cpap-and-cardiovascular-events-a-follow-up-study
#12
Francesco Baratta, Daniele Pastori, Mario Fabiani, Valerio Fabiani, Fabrizio Ceci, Rossella Lillo, Valeria Lolli, Marco Brunori, Gaetano Pannitteri, Elena Cravotto, Corrado De Vito, Francesco Angelico, Maria Del Ben
BACKGROUND: Previous studies suggested obstructive sleep apnea syndrome (OSAS) as a major risk factor for incident cardiovascular events. However, the relationship between OSAS severity, the use of continuous positive airway pressure (CPAP) treatment and the development of cardiovascular disease is still matter of debate. STUDY OBJECTIVES: The aim was to test the association between OSAS and cardiovascular events in patients with concomitant cardio-metabolic diseases and the potential impact of CPAP therapy on cardiovascular outcomes...
February 9, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29422547/concurrent-presence-of-obstructive-sleep-apnea-and-elevated-homocysteine-levels-exacerbate-the-development-of-hypertension-a-koges-six-year-follow-up-study
#13
Jinkwan Kim, Seung Ku Lee, Dae Wui Yoon, Chol Shin
Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of hypertension and cardiovascular disease. We investigated whether the presence of elevated Hcy levels among individuals with OSA increase the risk of hypertension in a cohort study. A total of 1825 participants were selected from the cohort study. A high homocysteine level (Hcy) was defined as those in the 75th percentile of Hcy levels of the study cohort. The prevalence of hypertension was higher among subjects with OSA and high Hcy levels than among the other groups stratified by the presence of OSA and high Hcy levels...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29412981/apnea-in-older-adults
#14
REVIEW
Susmita Chowdhuri, Pragnesh Patel, M Safwan Badr
Sleep-disordered breathing (SDB) is a highly prevalent chronic disease in older adults. A growing body of evidence demonstrates that SDB in older adults is linked to many adverse cardiovascular, neurocognitive, and metabolic sequelae. However, several unanswered questions remain regarding the diagnosis, consequences, and treatment of SDB in older adults. This review presents the current evidence pertaining to the management of SDB in older adults and identifies crucial gaps in knowledge that need further investigation...
March 2018: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29411336/central-sleep-apnea-with-cheyne-stokes-breathing-in-heart-failure-from-research-to-clinical-practice-and-beyond
#15
K Terziyski, A Draganova
Characterized by periodic crescendo-decrescendo pattern of breathing alternating with central apneas, Central sleep apnea (CSA) with Cheyne-Stokes Breathing represents a highly prevalent, yet underdiagnosed comorbidity in chronic heart failure (CHF). A diverse body of evidence demonstrates increased morbidity and mortality in the presence of CSB. CSB has been described in both CHF patients with preserved and reduced ejection fraction, regardless of drug treatment. Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29407894/low-sleep-quality-is-associated-with-progression-of-arterial-stiffness-in-patients-with-cardiovascular-risk-factors-hscaa-study
#16
Manabu Kadoya, Masafumi Kurajoh, Miki Kakutani-Hatayama, Akiko Morimoto, Akio Miyoshi, Kae Kosaka-Hamamoto, Takuhito Shoji, Yuji Moriwaki, Masaaki Inaba, Hidenori Koyama
BACKGROUND AND AIMS: Improvement in sleep quality is considered to be a viable target for prevention and treatment of cardiovascular diseases. To gain insight into its underlying mechanisms, we evaluated the significance of objectively measured sleep quality in patients with regard to progression of arterial stiffness over a 3-year follow-up period. METHODS: This prospective cohort study included 306 serial patients registered in the Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) study...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29406938/metabolic-syndrome-systems-thinking-in-heart-disease
#17
REVIEW
Ron Dommermuth, Kristine Ewing
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors. MetS is associated with approximately 4-fold increase in the likelihood of developing type 2 diabetes mellitus (T2DM) and a 2-fold increase in the incidence of cardiovascular disease complications. MetS is a progressive, proinflammatory, prothrombotic condition that manifests itself along a broad spectrum of disease. It is associated with hypertension, obstructive sleep apnea, fatty liver disease, gout, and polycystic ovarian syndrome. Intervening in and reversing the pathologic process become more difficult as the disease progresses, highlighting the needs for increased individual and community surveillance and primary prevention...
March 2018: Primary Care
https://www.readbyqxmd.com/read/29404173/results-of-polysomnographies-and-treatment-strategies-in-elderly-patients-with-symptoms-of-obstructive-sleep-apnea-syndrome
#18
Baran Balcan, Aylin Özsancak Uğurlu
OBJECTIVES: In this study, we evaluated data regarding the management of geriatric patients with symptoms of obstructive sleep apnea syndrome (age, >65 years) who were admitted to our sleep clinic. MATERIAL AND METHODS: Symptoms and sleep data of the patients were retrospectively evaluated, and the patients were reevaluated after treatment. RESULTS: A total of 85 patients with a median age of 69 years were included. Snoring and fatigue were the most common symptoms...
October 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29388357/airway-obstruction-produces-widespread-sympathoexcitation-role-of-hypoxia-carotid-chemoreceptors-and-nts-neurotransmission
#19
Caroline B Ferreira, Sergio L Cravo, Sean D Stocker
Obstructive sleep apnea (OSA) is the most common respiratory disturbance of sleep and is closely associated to cardiovascular diseases. In humans, apnea increases respiratory effort and elevates muscle sympathetic nerve activity (SNA), but the primary stimulus for the SNA activation has not been identified. We recently developed a model of apnea in rodents using acute airway obstruction. In this study, we employed this model to test whether the elevation in SNA was mediated by hypoxia, carotid chemoreceptors, or neurotransmission in the nucleus tractus solitarius (NTS)...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29383868/impact-of-testosterone-replacement-therapy-on-thromboembolism-heart-disease-and-obstructive-sleep-apnea-in-men
#20
Alexander P Cole, Julian Hanske, Wei Jiang, Nicollette K Kwon, Stuart R Lipsitz, Martin N Kathrins, Peter A Learn, Maxine Sun, Adil H Haider, Shehzad S Basaria, Quoc-Dien Trinh
OBJECTIVES: To assess the association of TRT with thromboembolism, cardiovascular disease (stroke, coronary artery disease, and heart failure) and obstructive sleep apnea (OSA). METHODS: A cohort of 3,422 male United States military service members, retirees and their dependents, aged 40-64 was identified, who were prescribed TRT between 2006-2010 for low testosterone. Men in this cohort were matched on a 1:1 basis by age and comorbidities to men without a prescription for TRT...
January 30, 2018: BJU International
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