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Sleep apnea and cardiovascular disease

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https://www.readbyqxmd.com/read/29241747/pathophysiology-of-the-metabolic-syndrome
#1
Emma McCracken, Monica Monaghan, Shiva Sreenivasan
The metabolic syndrome-otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and "the deadly quartet"-is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dyslipidemia. It is a prothrombotic and proinflammatory state characterized by increased inflammatory cytokine activity. In addition to inflammatory dermatoses such as psoriasis, lichen planus, and hidradenitis suppurativa, metabolic syndrome is also commonly associated with accelerated atherosclerotic cardiovascular disease, hyperuricemia/gout, chronic kidney disease, and obstructive sleep apnea...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29231011/-research-progress-of-the-relationship-between-sunds-and-osahs
#2
REVIEW
Y D Wu, L Y Zhang, J D Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is always a difficulty in forensic medicine researches. Although the development of molecular genetics promotes the etiologic study of SUNDS, the pathogenesis of most such cases is still unclear. Sleep apnea syndrome (SAS) is one of the common forms of sleep disorders, and obstructive sleep apnea hypopnea syndrome (OSAHS) is the most common. In recent years, some domestic and international researches show that OSAHS is related to the development of cardiovascular disease, which may cause cardiac arrhythmia, even sudden death...
February 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29212465/association-of-24%C3%A2-h-systolic-blood-pressure-variability-and-cardiovascular-disease-in-patients-with-obstructive-sleep-apnea
#3
Xiao Ke, Yan Sun, Rongfeng Yang, Jiawen Liang, Shaoyun Wu, Chengheng Hu, Xing Wang
BACKGROUND: To evaluate association of 24 h-systolic blood pressure (SBP) variability and obstructive sleep apnea (OSA) as defined by the apnea-hypopnea index ≥5/h; and association of 24 h-SBP variability and prevalent cardiovascular disease (CVD) in OSA patients. METHODS: Participants underwent polysomongraphy to evaluate the presence of OSA, and 24 h-ambulatory blood pressure monitoring was applied to evaluate 24 h-SBP variability as indexed by weighted 24 h-standard deviation (SD) of SBP...
December 6, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29198297/sleep-apnea-in-patients-hospitalized-with-acute-ischemic-stroke-underrecognition-and-associated-clinical-outcomes
#4
Nura Festic, David Alejos, Vikas Bansal, Lesia Mooney, Paul A Fredrickson, Pablo R Castillo, Emir Festic
STUDY OBJECTIVES: To evaluate clinical recognition of sleep apnea and related outcomes in patients hospitalized with acute ischemic stroke. METHODS: A retrospective study of all patients hospitalized with acute ischemic stroke from April 2008 to December 2014. The primary predictor and outcome variables were sleep apnea and hospital mortality, respectively. Secondary outcomes were mechanical ventilation, hospital length of stay, and the survivor's functional level by the modified Rankin scale...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29184787/correlation-of-self-reported-urologic-symptoms-with-systemic-health-conditions-in-minority-men
#5
Sarah Coleman Vij, Andrew Turk, Tianming Gao, Daniel A Shoskes
Background: To investigate the correlation between presence and severity of urologic symptoms and self-reported systemic health conditions in minority men. Methods: Questionnaires were distributed at a Men's Minority Health Fair. Urologic symptoms were assessed with the International Prostate Symptom Score (IPSS), Sexual Health Inventory for Men (SHIM) and NIH Chronic Prostatitis Symptom Score (CPSI). Each was graded as absent/mild [0], moderate [1] or severe [2] by standard criteria for each and totaled for a urologic score (US)...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29177626/non-surgical-treatment-of-obstructive-sleep-apnea-syndrome
#6
REVIEW
Xu Tingting, You Danming, Chen Xin
Obstructive sleep apnea syndrome (OSAS), a pervasive disease, is closely associated with complications such as cardiovascular diseases, neurocognitive diseases, and metabolic syndromes. Continuous positive airway pressure (CPAP) is the standard treatment for OSAS, with low compliance due to multifarious factors. The two other modes of ventilation, bi-level positive airway pressure (BPAP) and autotitrating positive airway pressure (APAP), which were developed from CPAP, are slightly different from CPAP in specific groups, as well as the corresponding treatment effect and compliance...
November 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29177130/sleep-disordered-breathing-and-spinal-cord-injury-challenges-and-opportunities
#7
Abdulghani Sankari, Jennifer L Martin, M Safwan Badr
Purpose of review: This paper focuses on the sleep disorders in patients with spinal cord injury (SCI/D), particularly mechanism of sleep disordered breathing (SDB) and challenges in diagnosis and management. Based on a review of recent literatures and studies the paper summarizes some main challenges with respect to management of SDB in patients with SCI; and what are the responsible mechanisms of disease? What are the barriers in diagnosing and treating SDB using standard treatment such as positive airway pressure (CPAP)?...
December 2017: Current Sleep Medicine Reports
https://www.readbyqxmd.com/read/29174957/alternatives-to-testosterone-therapy-a-review
#8
REVIEW
Eric M Lo, Katherine M Rodriguez, Alexander W Pastuszak, Mohit Khera
INTRODUCTION: Although testosterone therapy (TTh) is an effective treatment for hypogonadism, recent concerns regarding its safety have been raised. In 2015, the US Food and Drug Administration issued a warning about potential cardiovascular risks resulting from TTh. Fertility preservation is another reason to search for viable alternative therapies to conventional TTh, and in this review we evaluate the literature examining these alternatives. AIMS: To review the role and limitations of non-testosterone treatments for hypogonadism...
November 23, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29172793/impact-of-obstructive-sleep-apnea-on-blood-pressure-and-cardiovascular-risk-factors-in-japanese-men-a-cross-sectional-study-in-work-site-group
#9
Yuki Morinaga, Kiyoshi Matsumura, Yasuo Kansui, Satoko Sakata, Kenichi Goto, Yoshie Haga, Emi Oishi, Takunori Seki, Toshio Ohtsubo, Takanari Kitazono
It has been shown that obstructive sleep apnea (OSA) is related to hypertension and cardiovascular disease; however, the prevalence of OSA in general population and the impact of it on blood pressure especially in Japan has not been well determined. We have conducted a screening test for OSA from 2003 to 2011. In addition, a cross-sectional analysis was performed in 2012 to determine the association of OSA and cardiovascular risk factors in Japanese men (18-69 years of age; mean age, 44.4 ± 0.2). The study group consisted of 2208 male employees, and OSA was evaluated by using the 4% oxygen desaturation index and apnea-hypopnea index (AHI)...
November 27, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29168015/ascending-aortic-blood-flow-velocity-is-increased-in-children-with-primary-snoring-mild-sleep-disordered-breathing-and-associated-with-an-increase-in-cd8-%C3%A2-t-cells-expressing-tnf%C3%AE-and-ifn%C3%AE
#10
Anna Kontos, Scott Willoughby, Cameron van den Heuvel, Declan Kennedy, James Martin, Greg Hodge, Matthew Worthley, Adelene Kaihui Chin, Adam Nelson, Karen Teo, Mathias Baumert, Yvonne Pamula, Kurt Lushington
Sleep-disordered breathing (SDB) is associated with cardiovascular disease and systemic inflammation in adults but this remains to be explored in children, especially in children with the most common form of SDB, i.e. primary snoring/mild SDB. This pilot study investigated the relationship between the cardiovascular function and inflammation in children with mild SDB. Nineteen participants aged 5-14 years underwent overnight polysomnography, cardiac magnetic resonance imaging (aortic blood flow velocity and left and right ventricular systolic function) and assessment for inflammatory markers (intracellular cytokine analysis of T cells by flow cytometry)...
November 22, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29166886/trends-in-cardiovascular-risk-factors-among-u-s-men-and-women-with-and-without-diabetes-1988-2014
#11
Xingxing Sun, Tingting Du
BACKGROUND: Studies evidenced that reduction in cardiovascular disease (CVD) mortality in diabetic patients can be attributed to improvements in major CVD risk factors and evidence-based treatments. Furthermore, studies showed that the relative risk of CVD mortality associated with diabetes compared with non-diabetes is stronger in women than in men. Hence, we aimed to examine trends in CVD risk factors and intervention measures by sex and diabetic status. METHODS: Analysis of 5 distinct cross-sectional National Health and Nutrition Examination Surveys, 1988-1994, 1999-2002, 2003-2006, 2007-2010, and 2010-2014...
November 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29164122/changes-in-expression-of-the-clock-gene-in-obstructive-sleep-apnea-syndrome-patients-are-not-reverted-by-continuous-positive-airway-pressure-treatment
#12
Susana Moreira, Raquel Rodrigues, André B Barros, Nadja Pejanovic, Ana Neves-Costa, Dora Pedroso, Cláudia Pereira, Dina Fernandes, João Valença Rodrigues, Cristina Barbara, Luís Ferreira Moita
Purpose: Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29154950/murine-models-of-sleep-apnea-functional-implications-of-altered-macrophage-polarity-and-epigenetic-modifications-in-adipose-and-vascular-tissues
#13
Wojciech Trzepizur, Rene Cortese, David Gozal
Obstructive sleep apnea (OSA) is a highly prevalent disease across the lifespan, is characterized by chronic intermittent hypoxia and sleep fragmentation, and has been independently associated with substantial cardiometabolic morbidity. However, the reversibility of end-organ morbidity with treatment is not always apparent, suggesting that both tissue remodeling and epigenetic mechanisms may be operationally involved. Here, we review the cumulative evidence focused around murine models of OSA to illustrate the temporal dependencies of cardiometabolic dysfunction and its reversibility, and more particularly to discuss the critical contributions of tissue macrophages to adipose tissue insulin resistance and vascular atherogenesis...
November 15, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29142787/sleep-apnea-symptoms-and-cardiovascular-disease-risks-among-haitian-medical-students
#14
Diana M Rosenthal, Donaldson F Conserve, Dodley Severe, Michaele A Gedeon, Ferdinand Zizi, Georges Casimir, Samy I McFarlane, Girardin Jean Louis
Sleep apnea is a prevalent sleep disorder that disproportionately affects blacks and has been previously studied among Caribbean-born blacks in Brooklyn, New York, but there has been negligible research in the Caribbean, specifically Haiti, and developing countries on this pressing health issue. A total of 373 medical students (mean age=20.6 years ± 2.3 years) from a medical school in Haiti participated in this study. Participants were administered a questionnaire assessing their sleep health and cardiovascular outcomes...
April 2017: Journal of Sleep Disorders & Therapy
https://www.readbyqxmd.com/read/29141154/obstructive-sleep-apnea-and-cardiovascular-disease-rem-sleep-matters
#15
Babak Mokhlesi, Andrew W Varga
No abstract text is available yet for this article.
November 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29132198/clinical-features-of-snoring-patients-during-sedative-endoscopy
#16
Jung Wha Chung, Nayoung Kim, Jee Hye Wee, Jaebong Lee, Jongchan Lee, Soohoon Kwon, Young-Jae Hwang, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Jin-Wook Kim
Background/Aims: Snoring is the sound of turbulence and vibration of the upper respiratory tissues and has been identified as a risk factor of obstructive sleep apnea (OSA) and cardiovascular disease. The aim of this study was to identify associated clinical factors in snoring patients undergoing sedative endoscopy. Methods: A total of 49 patients who snored during standard sedative endoscopy and 127 controls were prospectively enrolled from June 2015 to June 2016...
November 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29126756/-vascular-dysfunction-in-obstructive-sleep-apnoea-implication-of-microparticules
#17
REVIEW
W Trzepizur, P Priou, N Meslier, T Urban, M C Martínez, R Andriantsitohaina, F Gagnadoux
Obstructive sleep apnea (OSA) is associated with increased cardiovascular diseases, including myocardial infarction and stroke and promotes cardiovascular risk factors including diabetes and hypertension. OSA has also been proposed to have a direct proatherogenic effects. Recent studies have investigated the role of microparticles (MPs) in the atherogenic process. MPs are small plasma membrane vesicles that can be released by a variety of vascular or blood cells and that contain membrane and cytosolic elements...
November 7, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29122399/-sleep-apneas-metabolic-syndrome-and-cardiovascular-risk-data-from-the-pays-de-la-loire-sleep-cohort
#18
REVIEW
F Gagnadoux, P Priou, T Urban, N Meslier, W Trzepizur
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent disease characterized by recurrent episodes of partial or complete obstruction of upper airway during sleep. Untreated moderate to severe OSAHS is recognized as a cardiovascular (CV) risk factor. Data from the Pays de la Loire sleep cohort and other clinic- or population-based cohorts demonstrate a strong association between OSAHS and the different components of the metabolic syndrome including systemic hypertension, diabetes and impaired lipid metabolism...
November 6, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29121095/the-pedunculopontine-tegmentum-controls-renal-sympathetic-nerve-activity-and-cardiorespiratory-activities-in-nembutal-anesthetized-rats
#19
Anne M Fink, Caron Dean, Mariann R Piano, David W Carley
Elevated renal sympathetic nerve activity (RSNA) accompanies a variety of complex disorders, including obstructive sleep apnea, heart failure, and chronic kidney disease. Understanding pathophysiologic renal mechanisms is important for determining why hypertension is both a common sequelae and a predisposing factor of these disorders. The role of the brainstem in regulating RSNA remains incompletely understood. The pedunculopontine tegmentum (PPT) is known for regulating behaviors including alertness, locomotion, and rapid eye movement sleep...
2017: PloS One
https://www.readbyqxmd.com/read/29118860/coronary-flow-reserve-is-impaired-in-patients-with-obstructive-sleep-apnea
#20
Serife Savas Bozbas, Serpil Eroglu, Berna Akinci Ozyurek, Fusun Oner Eyuboglu
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is common in adult populations. Accumulating data indicate that it is independently associated with a variety of cardiovascular diseases and has prognostic importance in affected cases. In this study, we aimed to evaluate coronary flow reserve (CFR) in patients with OSA and controls. METHODS: Sixty-one patients undergoing an overnight polysomnography were enrolled in this study. Patients with an apnea-hypopnea index (AHI) >5 were accepted as OSA group (n = 45) and those with an AHI <5 were taken as controls (n = 16)...
October 2017: Annals of Thoracic Medicine
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