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Sleep apnea and cardiovascular disease

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https://www.readbyqxmd.com/read/29676667/evaluating-the-clinical-value-of-the-hypoxia-burden-index-in-patients-with-obstructive-sleep-apnea
#1
Fengwei Chen, Kun Chen, Cheng Zhang, Xue Chen, Junjun Huang, Peng Jia, Jing Ma, Jue Zhang, Jing Fang, Guangfa Wang
PURPOSE: We aimed to develop a novel index, the hypoxia burden index (HBI), that reflects the degree and duration of oxygen desaturation, and to determine whether this index is better than the apnea hypopnea-index (AHI) for evaluating obstructive sleep apnea (OSA) and cardiovascular diseases morbidities. METHODS: We retrospectively analyzed 459 adult subjects who underwent overnight polysomnography (PSG) in this study. The HBI was calculated by dividing the total desaturation area of SpO2 below 90% by the TST measured in seconds...
April 20, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29671205/impact-of-continuous-positive-airway-pressure-on-vascular-endothelial-growth-factor-in-patients-with-obstructive-sleep-apnea-a-meta-analysis
#2
REVIEW
Jia-Chao Qi, LiangJi Zhang, Hao Li, Huixue Zeng, Yuming Ye, Tiezhu Wang, Qiyin Wu, Lida Chen, Qiaozhen Xu, Yifeng Zheng, Yaping Huang, Li Lin
PURPOSE: Cumulative evidence supports the clear relationship of obstructive sleep apnea (OSA) with cardiovascular disease (CVD). And, adherence to continuous positive airway pressure (CPAP) treatment alleviates the risk of CVD in subjects with OSA. Vascular endothelial growth factor (VEGF), a potent angiogenic cytokine regulated by hypoxia-inducible factor, stimulates the progression of CVD. Thus, whether treatment with CPAP can actually decrease VEGF in patients with OSA remains inconclusive...
April 18, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29662508/obstructive-sleep-apnea-is-associated-with-severity-and-long-term-prognosis-of-acute-coronary-syndrome
#3
Shuo Jia, Yu-Jie Zhou, Yi Yu, Si-Jing Wu, Yan Sun, Zhi-Jian Wang, Xiao-Li Liu, Bright Eric King, Ying-Xin Zhao, Dong-Mei Shi, Yu-Yang Liu, Zhi-Ming Zhou
Background: Obstructive sleep apnea (OSA) is a common disease in patients with acute coronary syndrome (ACS) and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods: In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29659956/polyphenols-have-no-impact-on-endothelial-function-in-patients-with-obstructive-sleep-apnea-a-randomized-controlled-trial
#4
Wojciech Trzepizur, Vanessa Bironneau, Sylvain Recoquillon, Pascaline Priou, Nicole Meslier, Jean-François Hamel, Samir Henni, Astrid Darsonval, Khaled Messaoudi, Maria Carmen Martínez, Ramaroson Andriantsitohaina, Frédéric Gagnadoux
Background: Endothelial dysfunction, a pathophysiologic determinant of atherogenesis, has been found to occur in obstructive sleep apnea syndrome (OSA) and is improved by continuous positive airway pressure (CPAP). However, the efficacy of CPAP therapy is limited by variable adherence. Alternative treatment strategies are needed. The impact of polyphenols on endothelial function has never been evaluated in OSA. Objective: We evaluated the impact of 1-mo supplementation with grape juice polyphenols (GJPs) on the reactive hyperemia index (RHI), a validated measure of endothelial function in patients with severe OSA...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29652543/cardioprotection-by-intermittent-hypoxia-conditioning-evidence-mechanisms-and-therapeutic-potential
#5
Robert T Mallet, Eugenia B Manukhina, Steven S Ruelas, James L Caffrey, H Fred Downey
The calibrated application of limited duration, cyclic, moderately intense hypoxia-reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These intermittent hypoxic conditioning (IHC) programs consistently produce striking reductions in myocardial infarction and ventricular tachyarrhythmias following coronary artery occlusion and reperfusion, and in many cases, improved contractile function and coronary blood flow. These IHC protocols are fundamentally different from those used to simulate sleep apnea, a recognized cardiovascular risk factor...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29625769/correlation-between-body-mass-index-and-obstructive-sleep-apnea-severity-indexes-a-retrospective-study
#6
Domenico Ciavarella, Michele Tepedino, Claudio Chimenti, Giuseppe Troiano, Manuela Mazzotta, Maria Pia Foschino Barbaro, Lorenzo Lo Muzio, Michele Cassano
PURPOSE: To evaluate if Body Mass Index (BMI) is correlated to Apnea-Hypopnea Index (AHI), mean arterial oxygen saturation (SaO2 ) and Nadir SaO2 , which are all indexes defining the severity of the respiratory stress associated with Obstructive Sleep Apnea (OSA). MATERIALS AND METHODS: Seventy-five adult patients (mean age 51.4) referred for polysomnography were retrospectively recruited. BMI was calculated for each patient, as well as AHI, SaO2 , and Nadir SaO2 recorded during polysomnography...
March 27, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29615922/sensory-processing-and-integration-at-the-carotid-body-tripartite-synapse-neurotransmitter-functions-and-effects-of-chronic-hypoxia
#7
REVIEW
Erin M Leonard, Shaima Salman, Colin A Nurse
Maintenance of homeostasis in the respiratory and cardiovascular systems depends on reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in the chemical composition of arterial blood. In mammals, the bilaterally-paired carotid bodies (CBs) are the main peripheral chemoreceptor organs that are richly vascularized and are strategically located at the carotid bifurcation. The CBs contribute to the maintenance of O2 , CO2 /H+ , and glucose homeostasis and have attracted much clinical interest because hyperactivity in these organs is associated with several pathophysiological conditions including sleep apnea, obstructive lung disease, heart failure, hypertension, and diabetes...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29608761/correlates-and-consequences-central-sleep-apnea-in-a-national-sample-of-u-s-veterans
#8
David Ratz, Wyndy Wiitala, M S Badr, Jennifer Burns, Susmita Chowdhuri
The prevalence and consequences of central sleep apnea (CSA) in adults are not well- described. By utilizing the large Veterans Health Administration (VHA) national administrative databases, we sought to determine the incidence, clinical correlates and impact of CSA on healthcare utilization in Veterans. Analysis of a retrospective cohort of patients with sleep disorders was performed from outpatient visits and inpatient admissions from fiscal years 2006 through 2012. The CSA group, defined by International Classification of Diseases-9, was compared to a non-CSA group...
March 28, 2018: Sleep
https://www.readbyqxmd.com/read/29603807/factors-associated-with-undiagnosed-obstructive-sleep-apnea-among-hypertensive-patients-a-multisite-cross-sectional-study-in-taiwan
#9
Hsiu-Chin Hsu, Mei-Hsiang Lin, Ning-Hung Chen, Wan Jing Ho
AIMS AND OBJECTIVE: To investigate the distribution and risk factors associated with undiagnosed Obstructive Sleep Apnea (OSA) among hypertensive patients. BACKGROUND: OSA has been deemed a cardinal risk factor affecting cardiovascular event, the condition is still frequently overlooked clinically. The lack of advanced diagnosis often causes hypertensive patients with OSA to miss opportunities for preventing chronic diseases. DESIGN: A cross-sectional design...
March 31, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29598850/evaluation-of-risk-factors-for-complications-after-bariatric-surgery
#10
D Quilliot, M-A Sirveaux, C Nomine-Criqui, T Fouquet, N Reibel, L Brunaud
The decision to perform a bariatric surgical procedure, the conclusion of a clinical pathway in which management is individually adapted to each patient, is taken after multidisciplinary consultation. Paradoxically, the patients who would most benefit from surgery are also those who have the highest operative risk. In practice, predictive factors of mortality and severe postoperative complications (Clavien-Dindo>III) must be used to evaluate the benefit/risk ratio most objectively. The main risk factors are age, male gender, body mass index, obstructive sleep apnea syndrome, insulin resistance and diabetes, tobacco abuse, cardiovascular disease, ability to lose weight before surgery, hypoalbuminemia and functional disability...
March 26, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29572132/sleep-biology-updates-hemodynamic-and-autonomic-control-in-sleep-disorders
#11
REVIEW
Renaud Tamisier, J Woodrow Weiss, Jean Louis Pépin
Sleep disorders like obstructive sleep apnea syndrome, periodic limb movements in sleep syndrome, insomnia and narcolepsy-cataplexy are all associated with an increased risk of cardiovascular diseases. These disorders share an impaired autonomic nervous system regulation that leads to increased cardiovascular sympathetic tone. This increased cardiovascular sympathetic tone is, in turn, likely to play a major role in the increased risk of cardiovascular disease. Different stimuli, such as intermittent hypoxia, sleep fragmentation, decrease in sleep duration, increased respiratory effort, and transient hypercapnia may all initiate the pathophysiological cascade leading to sympathetic overactivity and some or all of these are encountered in these different sleep disorders...
March 20, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29568980/sleep-apnea-in-heart-failure
#12
REVIEW
MuChun Tsai, Rami Khayat
PURPOSE OF REVIEW: In this review, we discuss the current treatment options for sleep-disordered breathing (SDB) in patients with heart failure (HF). We address the role of positive airway pressure (PAP) devices and other emerging therapies. The review includes discussion of recent trials that reported negative consequences for the PAP devices in patients with heart failure. RECENT FINDINGS: Optimal guideline-directed medical therapies of HF and PAP devices have been the mainstay treatments for HF patients with SDB...
March 22, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29566589/obstructive-sleep-apnea-and-risk-of-aortic-dissection-a-meta-analysis-of-observational-studies
#13
Xiushi Zhou, Fei Liu, Wei Zhang, Guili Wang, Daqiao Guo, Weiguo Fu, Lixin Wang
Objectives Obstructive sleep apnea acts as a potential risk factor for the development of cardiovascular disease. We undertook collaborative meta-analyses to clarify the risk of aortic dissection among adults suffering obstructive sleep apnea. Methods A systematic search of the databases (PubMed, Embase, and Cochrane Library) was performed. Studies reporting on the association between obstructive sleep apnea and aortic dissection were included. Information on 424 cases of aortic dissection in 56,291 patients from one cohort, four case-controls, and two cross-sectional studies were included in this study...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29548648/genetic-factors-in-sleep-disordered-breathing
#14
REVIEW
Kiminobu Tanizawa, Kazuo Chin
Sleep-disordered breathing (SDB) is characterized by repetitive episodes of decreased or arrested respiratory airflow during sleep. SDB is common and affects approximately 20% of the Japanese general population. Most traits of normal sleep and SDB show familial aggregation, suggesting significant effects of genetic factors. Obstructive sleep apnea (OSA) is the most common type of SDB and has a high heritability. Regardless of high heritability, no risk locus for OSA has reached a genome-wide level of significance (P < 5×10-8 ) in linkage or candidate gene analysis...
March 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29548630/sleep-apnea-morbidity-a-consequence-of-microbial-immune-cross-talk
#15
REVIEW
Nuria Farré, Ramon Farré, David Gozal
Obstructive Sleep Apnea (OSA) has emerged as a highly prevalent public health problem that imposes important mid-term and long-term consequences, namely cardiovascular, metabolic, cognitive and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction during sleep. Recurrent collapse of the upper airway develops with sleep onset, and is associated with both intermittent hypoxemia and sleep fragmentation. The microbiome is a vast and complex polymicrobial ecosystem that coexists with the human organism, and has been identified as playing significant roles in the development of host immunological phenotypes...
March 13, 2018: Chest
https://www.readbyqxmd.com/read/29537350/association-of-obstructive-sleep-apnea-with-microvascular-endothelial-dysfunction-and-subclinical-coronary-artery-disease-in-a-community-based-population
#16
Daniel Shpilsky, Sebhat Erqou, Sanjay R Patel, Kevin E Kip, Oluremi Ajala, Aryan Aiyer, Patrick J Strollo, Steven E Reis, Oladipupo Olafiranye
Studies have reported an association between obstructive sleep apnea (OSA) and cardiovascular disease (CVD) morbidity and mortality. Proposed mechanisms include endothelial dysfunction and atherosclerosis. We aimed to investigate the associations of OSA with endothelial dysfunction and subclinical atherosclerotic coronary artery disease (CAD), and assess the impact of race on these associations. We used data from the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a community-based prospective cohort with approximately equal representation of black and white participants...
March 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29534971/obesity-metabolic-and-hormonal-disorders-associated-with-obstructive-sleep-apnea-and-their-impact-on-the-risk-of-cardiovascular-events
#17
REVIEW
Glaucia Carneiro, Maria T Zanella
OBJECTIVE: To analyze metabolic and hormonal disorders resulting from the association between obesity and obstructive sleep apnea (OSA) syndrome that predispose to cardiovascular diseases and investigate the clinical benefits obtained from treatment approaches for both conditions. METHODS: A literature review between 1997 and 2017 was conducted in the PubMed search database. RESULTS: Obesity is the most important risk factor for OSA, and the progressive increase in its prevalence also affects OSA incidence...
March 10, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29533939/sleep-related-leg-movements-in-patients-with-transient-ischemic-attack-and-controls
#18
Mirjam H Schipper, Korné Jellema, Diego Alvarez-Estevez, Johan Verbraecken, Roselyne M Rijsman
BACKGROUND: Periodic leg movements during sleep (PLMS) have been associated with an increased risk for cardiovascular diseases and there is a high prevalence of PLMS found in patients with obstructive sleep apnea syndrome (OSAS). We evaluated patients with transient ischemic attack (TIA) for PLMS and respiratory related leg movements (RRLM), versus a control group without TIA. METHODS: Twenty-five patients with TIA and 34 patients with no vascular diagnosis were referred for polysomnography...
March 13, 2018: European Neurology
https://www.readbyqxmd.com/read/29530375/lower-plasma-choline-levels-are-associated-with-sleepiness-symptoms
#19
Victoria M Pak, Feng Dai, Brendan T Keenan, Nalaka S Gooneratne, Allan I Pack
Sleepiness and cardiovascular disease share common molecular pathways; thus, metabolic risk factors for sleepiness may also predict cardiovascular disease risk. Daytime sleepiness predicts mortality and cardiovascular disease, although the mechanism is unidentified. This study explored the associations between subjective sleepiness and metabolite concentrations in human blood plasma within the oxidative and inflammatory pathways, in order to identify mechanisms that may contribute to sleepiness and cardiovascular disease risk...
April 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29530366/joint-effects-of-osa-and-self-reported-sleepiness-on-incident-chd-and-stroke
#20
Rachel P Ogilvie, Kamakshi Lakshminarayan, Conrad Iber, Sanjay R Patel, Pamela L Lutsey
BACKGROUND: Although excessive daytime sleepiness (EDS) is a common symptom of obstructive sleep apnea (OSA), and both EDS and OSA have separately been associated with increased risk of cardiovascular disease (CVD), their joint association with CVD risk is unknown. METHODS: Among 3874 Sleep Heart Health Study (SHHS) participants without prevalent CVD, moderate to severe OSA was defined by an apnea hypopnea index (AHI) ≥ 15 on an in-home polysomnography. EDS was defined as an Epworth Sleepiness Scale score ≥11...
April 2018: Sleep Medicine
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